PCDHB5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)5.64411397
2neuron cell-cell adhesion (GO:0007158)5.45756269
3presynaptic membrane organization (GO:0097090)5.00751013
4postsynaptic membrane organization (GO:0001941)4.86029476
5paraxial mesoderm development (GO:0048339)4.82643934
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.81974688
7vocalization behavior (GO:0071625)4.70316074
8protein localization to synapse (GO:0035418)4.51806487
9regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.42840962
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.28371128
11ionotropic glutamate receptor signaling pathway (GO:0035235)4.22297970
12regulation of glutamate receptor signaling pathway (GO:1900449)4.10290405
13negative regulation of synaptic transmission, GABAergic (GO:0032229)4.03183758
14glutamate receptor signaling pathway (GO:0007215)4.01326568
15neurotransmitter-gated ion channel clustering (GO:0072578)3.94875179
16pyrimidine nucleobase catabolic process (GO:0006208)3.92132844
17positive regulation of synapse assembly (GO:0051965)3.81049613
18neuronal stem cell maintenance (GO:0097150)3.76077075
19neuron recognition (GO:0008038)3.73063899
20cerebral cortex radially oriented cell migration (GO:0021799)3.70914637
21synaptic transmission, glutamatergic (GO:0035249)3.56035848
22startle response (GO:0001964)3.55248554
23regulation of short-term neuronal synaptic plasticity (GO:0048172)3.51814815
24synaptic vesicle exocytosis (GO:0016079)3.49212572
25regulation of synapse assembly (GO:0051963)3.48355270
26limb bud formation (GO:0060174)3.47250759
27cerebellar granule cell differentiation (GO:0021707)3.44030915
28neuron-neuron synaptic transmission (GO:0007270)3.43942458
29G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.40036483
30neuron remodeling (GO:0016322)3.39940837
31regulation of synaptic transmission, glutamatergic (GO:0051966)3.29597852
32regulation of synapse maturation (GO:0090128)3.23509338
33long-chain fatty acid biosynthetic process (GO:0042759)3.21720017
34regulation of excitatory postsynaptic membrane potential (GO:0060079)3.19589585
35regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.17030549
36opioid receptor signaling pathway (GO:0038003)3.14440591
37axonal fasciculation (GO:0007413)3.14379562
38regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.12531586
39planar cell polarity pathway involved in neural tube closure (GO:0090179)3.11170767
40gamma-aminobutyric acid signaling pathway (GO:0007214)3.08072746
41neuronal action potential propagation (GO:0019227)3.06544694
42regulation of respiratory system process (GO:0044065)3.05578653
43nonmotile primary cilium assembly (GO:0035058)3.03774826
44regulation of postsynaptic membrane potential (GO:0060078)3.02548089
45positive regulation of membrane potential (GO:0045838)3.02100333
46* synapse assembly (GO:0007416)3.02002914
47auditory behavior (GO:0031223)2.98874957
48glutamate secretion (GO:0014047)2.97566018
49convergent extension (GO:0060026)2.94853824
50transmission of nerve impulse (GO:0019226)2.93326051
51regulation of synaptic vesicle exocytosis (GO:2000300)2.92888029
52nucleobase catabolic process (GO:0046113)2.92713991
53positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.91316096
54neuron projection extension involved in neuron projection guidance (GO:1902284)2.89637591
55axon extension involved in axon guidance (GO:0048846)2.89637591
56membrane assembly (GO:0071709)2.88816140
57regulation of cell fate specification (GO:0042659)2.88514637
58mechanosensory behavior (GO:0007638)2.88246166
59regulation of synapse organization (GO:0050807)2.87470878
60dendritic spine morphogenesis (GO:0060997)2.87433895
61synaptic vesicle docking involved in exocytosis (GO:0016081)2.86800433
62negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.86240294
63righting reflex (GO:0060013)2.83948207
64response to auditory stimulus (GO:0010996)2.83143224
65regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.81659545
66positive regulation of neurotransmitter secretion (GO:0001956)2.81444008
67* calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.80795128
68membrane depolarization (GO:0051899)2.79390957
69positive regulation of synaptic transmission, GABAergic (GO:0032230)2.78553980
70L-serine metabolic process (GO:0006563)2.77197718
71synaptic vesicle endocytosis (GO:0048488)2.75577764
72G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.75073884
73positive regulation of action potential (GO:0045760)2.74709063
74regulation of respiratory gaseous exchange (GO:0043576)2.73785508
75central nervous system projection neuron axonogenesis (GO:0021952)2.73277147
76positive regulation of dendritic spine morphogenesis (GO:0061003)2.72603484
77positive regulation of synapse maturation (GO:0090129)2.72598331
78cellular response to cholesterol (GO:0071397)2.71329547
79superoxide anion generation (GO:0042554)2.69704372
80establishment of nucleus localization (GO:0040023)2.69170491
81regulation of synaptic transmission, GABAergic (GO:0032228)2.68670590
82negative regulation of oligodendrocyte differentiation (GO:0048715)2.67896949
83dendrite development (GO:0016358)2.67694004
84neurotransmitter secretion (GO:0007269)2.65444771
85negative regulation of neurotransmitter transport (GO:0051589)2.64854592
86regulation of growth hormone secretion (GO:0060123)2.63583696
87learning (GO:0007612)2.61934577
88regulation of dendritic spine morphogenesis (GO:0061001)2.59783303
89response to histamine (GO:0034776)2.58112768
90cyclic nucleotide catabolic process (GO:0009214)2.58066297
91forebrain neuron differentiation (GO:0021879)2.57903514
92regulation of vesicle fusion (GO:0031338)2.57816834
93regulation of neurotransmitter secretion (GO:0046928)2.57772236
94sympathetic nervous system development (GO:0048485)2.57065928
95regulation of gene silencing by RNA (GO:0060966)2.55808230
96regulation of posttranscriptional gene silencing (GO:0060147)2.55808230
97regulation of gene silencing by miRNA (GO:0060964)2.55808230
98cAMP catabolic process (GO:0006198)2.55647352
99locomotory exploration behavior (GO:0035641)2.55405314
100cell migration in hindbrain (GO:0021535)2.55269291
101regulation of dendritic spine development (GO:0060998)2.54632934
102* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.53908907
103regulation of synaptic vesicle transport (GO:1902803)2.53814459
104notochord development (GO:0030903)2.53419981
105long-term synaptic potentiation (GO:0060291)2.52911907
106neurotransmitter transport (GO:0006836)2.52302233
107dendrite morphogenesis (GO:0048813)2.51524397
108layer formation in cerebral cortex (GO:0021819)2.50535413
109regulation of establishment of planar polarity (GO:0090175)2.49449077
110spinal cord association neuron differentiation (GO:0021527)2.49349394
111somite development (GO:0061053)2.49284951
112long-term memory (GO:0007616)2.49159500
113lateral sprouting from an epithelium (GO:0060601)2.48626410
114cholesterol biosynthetic process (GO:0006695)2.48263050
115negative regulation of axon guidance (GO:1902668)2.48188299
116regulation of long-term neuronal synaptic plasticity (GO:0048169)2.48183340
117limb development (GO:0060173)2.47464321
118appendage development (GO:0048736)2.47464321
119positive regulation of catenin import into nucleus (GO:0035413)2.46371302
120central nervous system neuron axonogenesis (GO:0021955)2.46259115
121adult behavior (GO:0030534)2.46078383
122Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.45777570
123membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.45635664
124apical protein localization (GO:0045176)2.44783078
125negative regulation of axon extension (GO:0030517)2.44521730
126digestive tract morphogenesis (GO:0048546)2.44517093
127positive regulation of dendritic spine development (GO:0060999)2.44188062
128exploration behavior (GO:0035640)2.43475788
129pre-miRNA processing (GO:0031054)2.42528190
130regulation of glutamate secretion (GO:0014048)2.42104617
131forebrain neuron development (GO:0021884)2.41709823
132* synapse organization (GO:0050808)2.41544794
133ectodermal placode formation (GO:0060788)2.41456288
134ephrin receptor signaling pathway (GO:0048013)2.41351516
135negative chemotaxis (GO:0050919)2.41343737
136retinal ganglion cell axon guidance (GO:0031290)2.41274577
137positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.40674298
138behavioral response to ethanol (GO:0048149)2.40642589
139olfactory bulb development (GO:0021772)2.40039540
140negative regulation of axon extension involved in axon guidance (GO:0048843)2.38805729
141membrane hyperpolarization (GO:0060081)2.37810659
142spinal cord development (GO:0021510)2.37570191
143negative regulation of cytosolic calcium ion concentration (GO:0051481)2.37439877
144dorsal/ventral axis specification (GO:0009950)2.36468497
145cell surface receptor signaling pathway involved in heart development (GO:0061311)2.36022695
146cranial nerve development (GO:0021545)2.32970188
147Notch signaling involved in heart development (GO:0061314)2.26983655
148hippocampus development (GO:0021766)2.25732476
149ganglion development (GO:0061548)2.25338000
150regulation of development, heterochronic (GO:0040034)2.23992528
151cellular response to sterol (GO:0036315)2.23525152
152prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.22523501
153cerebral cortex cell migration (GO:0021795)2.20394076
154establishment of planar polarity (GO:0001736)2.19194755
155establishment of tissue polarity (GO:0007164)2.19194755
156cell proliferation in forebrain (GO:0021846)2.17178240
157positive regulation of neuroblast proliferation (GO:0002052)2.16827862
158tongue development (GO:0043586)2.16747277
159growth hormone secretion (GO:0030252)2.16439606
160sterol biosynthetic process (GO:0016126)2.15374395
161intraciliary transport (GO:0042073)2.15309059
162establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.15165361
163lung-associated mesenchyme development (GO:0060484)2.14967337
164photoreceptor cell differentiation (GO:0046530)2.14192073
165eye photoreceptor cell differentiation (GO:0001754)2.14192073
166neuron fate determination (GO:0048664)2.13190836
167outer ear morphogenesis (GO:0042473)2.12736542
168non-canonical Wnt signaling pathway (GO:0035567)2.11418362
169neuron migration (GO:0001764)2.11163877
170inner ear receptor cell development (GO:0060119)2.10520410
171morphogenesis of an epithelial sheet (GO:0002011)2.10485861
172short-term memory (GO:0007614)2.09451972
173otic vesicle formation (GO:0030916)2.08433906
174negative regulation of glial cell differentiation (GO:0045686)2.05907901
175establishment of mitochondrion localization (GO:0051654)2.05015733
176* cell-cell adhesion via plasma-membrane adhesion molecules (GO:0098742)2.04022114
177* cell-cell adhesion (GO:0098609)2.03841690

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.81525756
2GBX2_23144817_ChIP-Seq_PC3_Human4.44369817
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89106778
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.86165044
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.78935234
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69807622
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.62337037
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.61261752
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.60702464
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59166153
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53991514
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.48713576
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.36959325
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.36959325
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.36743122
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.33927435
17TAF15_26573619_Chip-Seq_HEK293_Human2.26866649
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.25480102
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.17215141
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.14176405
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13808652
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.04101899
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.02649457
24* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.01309062
25AR_21572438_ChIP-Seq_LNCaP_Human2.00889741
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.00581187
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.98153995
28* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.98112829
29* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93398448
30WT1_19549856_ChIP-ChIP_CCG9911_Human1.91775938
31POU5F1_16153702_ChIP-ChIP_HESCs_Human1.90413741
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.87178283
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86971486
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85633871
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83496386
36P300_19829295_ChIP-Seq_ESCs_Human1.83329601
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.79002687
38REST_21632747_ChIP-Seq_MESCs_Mouse1.75456484
39FUS_26573619_Chip-Seq_HEK293_Human1.74826987
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.70972130
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68706432
42SMAD4_21799915_ChIP-Seq_A2780_Human1.66845046
43SOX2_16153702_ChIP-ChIP_HESCs_Human1.66437502
44RNF2_27304074_Chip-Seq_NSC_Mouse1.65880821
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.65710646
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65011171
47IGF1R_20145208_ChIP-Seq_DFB_Human1.64556474
48ZNF274_21170338_ChIP-Seq_K562_Hela1.63579091
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.63129087
50DROSHA_22980978_ChIP-Seq_HELA_Human1.62496333
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62170022
52SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.61368711
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.55946738
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54622605
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.54345685
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.51784696
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.50977714
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49141241
59SOX2_18555785_ChIP-Seq_MESCs_Mouse1.47331350
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46913346
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.46386236
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46028765
63ISL1_27105846_Chip-Seq_CPCs_Mouse1.45915471
64EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.45518454
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43820093
66ER_23166858_ChIP-Seq_MCF-7_Human1.42341167
67E2F1_18555785_Chip-Seq_ESCs_Mouse1.40623403
68STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.40618299
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40393587
70P53_22387025_ChIP-Seq_ESCs_Mouse1.36321199
71SUZ12_18555785_Chip-Seq_ESCs_Mouse1.35604826
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35093853
73GATA1_26923725_Chip-Seq_HPCs_Mouse1.34463332
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33961247
75EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33626412
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.33491489
77CMYC_18555785_Chip-Seq_ESCs_Mouse1.32953588
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31490978
79TP53_18474530_ChIP-ChIP_U2OS_Human1.30985921
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.30966574
81SOX9_26525672_Chip-Seq_HEART_Mouse1.28922858
82POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.28839277
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28056250
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28000843
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27543980
86SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.27124261
87HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.27033469
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26355696
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26355696
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25973272
91KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.25181405
92SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.24243108
93AR_25329375_ChIP-Seq_VCAP_Human1.23604200
94RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23095579
95STAT3_18555785_Chip-Seq_ESCs_Mouse1.23007142
96EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.22197989
97CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22131529
98OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.22007304
99STAT3_23295773_ChIP-Seq_U87_Human1.21804720
100NMYC_18555785_Chip-Seq_ESCs_Mouse1.20767287
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.20258106
102P300_18555785_Chip-Seq_ESCs_Mouse1.19262645
103RING1B_27294783_Chip-Seq_NPCs_Mouse1.19144523
104ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18030309
105VDR_22108803_ChIP-Seq_LS180_Human1.17099689
106NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16947822
107TBX3_20139965_ChIP-Seq_MESCs_Mouse1.16513730
108TBX3_20139965_ChIP-Seq_ESCs_Mouse1.16279187
109TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16031284
110NANOG_16153702_ChIP-ChIP_HESCs_Human1.15993212
111REST_18959480_ChIP-ChIP_MESCs_Mouse1.15570218
112TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.15505286
113CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15467973
114VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15221673
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15043874
116RUNX2_22187159_ChIP-Seq_PCA_Human1.14066305
117RING1B_27294783_Chip-Seq_ESCs_Mouse1.12992888
118SOX2_18555785_Chip-Seq_ESCs_Mouse1.11972657
119KDM2B_26808549_Chip-Seq_REH_Human1.11947496
120P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11519960
121RUNX1_27457419_Chip-Seq_LIVER_Mouse1.11489842
122TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11402284
123ARNT_22903824_ChIP-Seq_MCF-7_Human1.11058569
124ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09896621
125TCF4_23295773_ChIP-Seq_U87_Human1.09829735
126AHR_22903824_ChIP-Seq_MCF-7_Human1.09678015
127YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09478935
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08777450
129* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.08666154
130SOX2_21211035_ChIP-Seq_LN229_Gbm1.08074716
131TAL1_26923725_Chip-Seq_HPCs_Mouse1.07906702
132EWS_26573619_Chip-Seq_HEK293_Human1.07040234
133NANOG_21062744_ChIP-ChIP_HESCs_Human1.06531197
134ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06278260
135PU1_27457419_Chip-Seq_LIVER_Mouse1.04358941
136OCT4_18555785_Chip-Seq_ESCs_Mouse1.04025359
137KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03556670
138WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03538470
139ERG_21242973_ChIP-ChIP_JURKAT_Human1.02384385
140KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99085245
141KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99085245
142KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99085245
143NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.97381951
144CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.97229199
145FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96236927
146POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.95568928
147TCF3_18692474_ChIP-Seq_MESCs_Mouse0.94212389

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.17292484
2MP0001188_hyperpigmentation3.86270079
3MP0004859_abnormal_synaptic_plasticity3.79422853
4MP0003635_abnormal_synaptic_transmissio3.01903193
5MP0001968_abnormal_touch/_nociception2.97407996
6MP0010030_abnormal_orbit_morphology2.90071095
7MP0009745_abnormal_behavioral_response2.80411578
8MP0002064_seizures2.53453380
9MP0002736_abnormal_nociception_after2.52305231
10MP0002063_abnormal_learning/memory/cond2.51012903
11MP0001486_abnormal_startle_reflex2.50134526
12MP0005423_abnormal_somatic_nervous2.47701944
13MP0000566_synostosis2.40698555
14MP0002572_abnormal_emotion/affect_behav2.40478548
15MP0009046_muscle_twitch2.39154992
16MP0002735_abnormal_chemical_nociception2.38773428
17MP0000537_abnormal_urethra_morphology2.23569007
18MP0002272_abnormal_nervous_system2.20549052
19MP0004270_analgesia2.19696048
20MP0006276_abnormal_autonomic_nervous2.15595690
21MP0001501_abnormal_sleep_pattern2.14711428
22MP0005409_darkened_coat_color2.11115606
23MP0000778_abnormal_nervous_system2.07798094
24MP0002067_abnormal_sensory_capabilities1.97314907
25MP0005171_absent_coat_pigmentation1.96908327
26MP0002734_abnormal_mechanical_nocicepti1.95704353
27MP0005645_abnormal_hypothalamus_physiol1.85577281
28MP0003136_yellow_coat_color1.81285031
29MP0002184_abnormal_innervation1.78156345
30MP0004742_abnormal_vestibular_system1.75420185
31MP0001440_abnormal_grooming_behavior1.72540751
32MP0004133_heterotaxia1.72469573
33MP0002697_abnormal_eye_size1.71268183
34MP0003890_abnormal_embryonic-extraembry1.68162765
35MP0003787_abnormal_imprinting1.68135942
36MP0002557_abnormal_social/conspecific_i1.67795749
37MP0003937_abnormal_limbs/digits/tail_de1.67417281
38MP0001293_anophthalmia1.66453895
39MP0002254_reproductive_system_inflammat1.63568304
40MP0006292_abnormal_olfactory_placode1.61060736
41MP0009379_abnormal_foot_pigmentation1.60874019
42MP0001905_abnormal_dopamine_level1.59217401
43MP0005248_abnormal_Harderian_gland1.58040519
44MP0005646_abnormal_pituitary_gland1.57322832
45MP0002653_abnormal_ependyma_morphology1.56555261
46MP0004142_abnormal_muscle_tone1.54282207
47MP0003121_genomic_imprinting1.54030799
48MP0001970_abnormal_pain_threshold1.52792229
49MP0005394_taste/olfaction_phenotype1.50984591
50MP0005499_abnormal_olfactory_system1.50984591
51MP0001346_abnormal_lacrimal_gland1.49437972
52MP0002233_abnormal_nose_morphology1.46797983
53MP0001529_abnormal_vocalization1.45075804
54MP0003861_abnormal_nervous_system1.43789171
55MP0009384_cardiac_valve_regurgitation1.43547002
56MP0002733_abnormal_thermal_nociception1.41243152
57MP0008260_abnormal_autophagy1.40550906
58MP0002876_abnormal_thyroid_physiology1.40420952
59MP0003119_abnormal_digestive_system1.39395353
60MP0001502_abnormal_circadian_rhythm1.37228086
61MP0008789_abnormal_olfactory_epithelium1.35240892
62MP0002638_abnormal_pupillary_reflex1.34661522
63MP0002277_abnormal_respiratory_mucosa1.33671228
64MP0004924_abnormal_behavior1.31974443
65MP0005386_behavior/neurological_phenoty1.31974443
66MP0001986_abnormal_taste_sensitivity1.30940883
67MP0005551_abnormal_eye_electrophysiolog1.30376319
68MP0000579_abnormal_nail_morphology1.28108903
69MP0004272_abnormal_basement_membrane1.28000829
70MP0002751_abnormal_autonomic_nervous1.26538833
71MP0000955_abnormal_spinal_cord1.22878076
72MP0000026_abnormal_inner_ear1.21696551
73MP0003755_abnormal_palate_morphology1.21597082
74MP0002882_abnormal_neuron_morphology1.21398915
75MP0001963_abnormal_hearing_physiology1.20632359
76MP0008569_lethality_at_weaning1.20417467
77MP0005187_abnormal_penis_morphology1.20035739
78MP0001984_abnormal_olfaction1.19516295
79MP0002102_abnormal_ear_morphology1.18218157
80MP0000631_abnormal_neuroendocrine_gland1.17763415
81MP0001286_abnormal_eye_development1.16940306
82MP0003385_abnormal_body_wall1.16750610
83MP0000015_abnormal_ear_pigmentation1.16713731
84MP0003567_abnormal_fetal_cardiomyocyte1.16138063
85MP0004885_abnormal_endolymph1.13758923
86MP0000428_abnormal_craniofacial_morphol1.13532568
87MP0008877_abnormal_DNA_methylation1.13108763
88MP0009672_abnormal_birth_weight1.12988011
89MP0000569_abnormal_digit_pigmentation1.12486845
90MP0002092_abnormal_eye_morphology1.11831645
91MP0000647_abnormal_sebaceous_gland1.11628260
92MP0002066_abnormal_motor_capabilities/c1.10198440
93MP0003938_abnormal_ear_development1.07125266
94MP0000681_abnormal_thyroid_gland1.06442909
95MP0003942_abnormal_urinary_system1.06236205
96MP0003879_abnormal_hair_cell1.02398495
97MP0002909_abnormal_adrenal_gland1.02077101
98MP0000920_abnormal_myelination1.01383306
99MP0002084_abnormal_developmental_patter1.00184216
100MP0005257_abnormal_intraocular_pressure1.00061723
101MP0003935_abnormal_craniofacial_develop0.98934019
102MP0002822_catalepsy0.98864306
103MP0004197_abnormal_fetal_growth/weight/0.98436747
104MP0002111_abnormal_tail_morphology0.97575646
105MP0004811_abnormal_neuron_physiology0.97121901
106MP0009703_decreased_birth_body0.96789262
107MP0005391_vision/eye_phenotype0.96704590
108MP0008932_abnormal_embryonic_tissue0.96319301
109MP0002752_abnormal_somatic_nervous0.96287347
110MP0000534_abnormal_ureter_morphology0.95417112
111MP0002085_abnormal_embryonic_tissue0.94016168
112MP0002116_abnormal_craniofacial_bone0.91409929
113MP0005623_abnormal_meninges_morphology0.90276199
114MP0001177_atelectasis0.90032779
115MP0010386_abnormal_urinary_bladder0.89267490
116MP0003115_abnormal_respiratory_system0.86871642
117MP0002081_perinatal_lethality0.86710909
118MP0002234_abnormal_pharynx_morphology0.84773820
119MP0000462_abnormal_digestive_system0.84743735
120MP0003315_abnormal_perineum_morphology0.83534267
121MP0002177_abnormal_outer_ear0.82057546
122MP0002152_abnormal_brain_morphology0.80026704
123MP0000751_myopathy0.79058028
124MP0009780_abnormal_chondrocyte_physiolo0.79043769
125MP0000432_abnormal_head_morphology0.79022627
126MP0001664_abnormal_digestion0.78935538
127MP0001299_abnormal_eye_distance/0.78105614
128MP0000049_abnormal_middle_ear0.76638071
129MP0003123_paternal_imprinting0.75678286
130MP0003283_abnormal_digestive_organ0.75497848
131MP0000762_abnormal_tongue_morphology0.75330905
132MP0001485_abnormal_pinna_reflex0.74600363
133MP0005367_renal/urinary_system_phenotyp0.73489143
134MP0000516_abnormal_urinary_system0.73489143
135MP0003941_abnormal_skin_development0.73158227
136MP0005174_abnormal_tail_pigmentation0.72557413
137MP0004858_abnormal_nervous_system0.71306722
138MP0003011_delayed_dark_adaptation0.69563370
139MP0003634_abnormal_glial_cell0.67826587
140MP0003122_maternal_imprinting0.67635391
141MP0005253_abnormal_eye_physiology0.66858908
142MP0003633_abnormal_nervous_system0.66594282
143MP0002229_neurodegeneration0.64873218
144MP0009250_abnormal_appendicular_skeleto0.62419776
145MP0004484_altered_response_of0.62393196
146MP0002938_white_spotting0.61892989
147MP0003631_nervous_system_phenotype0.61775705
148MP0002069_abnormal_eating/drinking_beha0.61750553
149MP0006072_abnormal_retinal_apoptosis0.57647988
150MP0000383_abnormal_hair_follicle0.57123538

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.59558442
2Febrile seizures (HP:0002373)4.82340198
3Epileptic encephalopathy (HP:0200134)4.50190793
4Hyperventilation (HP:0002883)4.23800600
5Focal seizures (HP:0007359)4.03548408
6Broad-based gait (HP:0002136)4.01011389
7Atonic seizures (HP:0010819)3.61819298
8Fetal akinesia sequence (HP:0001989)2.95680055
9Generalized tonic-clonic seizures (HP:0002069)2.95318734
10Parakeratosis (HP:0001036)2.89001664
11Rib fusion (HP:0000902)2.88036207
12Hepatoblastoma (HP:0002884)2.86561128
13Amblyopia (HP:0000646)2.85925157
14Protruding tongue (HP:0010808)2.82465496
15Dynein arm defect of respiratory motile cilia (HP:0012255)2.81829095
16Absent/shortened dynein arms (HP:0200106)2.81829095
17Hypothermia (HP:0002045)2.79798491
18Myokymia (HP:0002411)2.79317559
19Septo-optic dysplasia (HP:0100842)2.78691730
20Cortical dysplasia (HP:0002539)2.72501372
21Progressive cerebellar ataxia (HP:0002073)2.72275740
22Dialeptic seizures (HP:0011146)2.62991336
23Gaze-evoked nystagmus (HP:0000640)2.56620712
24Absent speech (HP:0001344)2.50991511
25Cutaneous syndactyly (HP:0012725)2.49922139
26Limb dystonia (HP:0002451)2.48927214
27Hemivertebrae (HP:0002937)2.43846305
28Absence seizures (HP:0002121)2.43544043
29Drooling (HP:0002307)2.42769725
30Excessive salivation (HP:0003781)2.42769725
31Turricephaly (HP:0000262)2.41136423
32Anophthalmia (HP:0000528)2.40953390
33Decreased central vision (HP:0007663)2.38891541
34Colon cancer (HP:0003003)2.37953823
35Medial flaring of the eyebrow (HP:0010747)2.37057550
36Optic nerve hypoplasia (HP:0000609)2.35475948
37Absent septum pellucidum (HP:0001331)2.35163603
38Coronal craniosynostosis (HP:0004440)2.34625698
39Intestinal atresia (HP:0011100)2.33126938
40Inability to walk (HP:0002540)2.32537047
41Blue irides (HP:0000635)2.27963340
42Poor eye contact (HP:0000817)2.27555279
43Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.27392136
44Degeneration of the lateral corticospinal tracts (HP:0002314)2.27392136
45Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.27110180
46Bifid tongue (HP:0010297)2.27046892
47Trigonocephaly (HP:0000243)2.26513868
48Conical tooth (HP:0000698)2.26184623
49Gait imbalance (HP:0002141)2.26043001
50Long nose (HP:0003189)2.25540626
51Renal hypoplasia (HP:0000089)2.24552898
52Akinesia (HP:0002304)2.24182772
53Choanal stenosis (HP:0000452)2.20922422
54Sensory axonal neuropathy (HP:0003390)2.16982637
55Exotropia (HP:0000577)2.16898549
56Abnormality of salivation (HP:0100755)2.16666001
57Abnormality of the diencephalon (HP:0010662)2.14746110
58Thickened helices (HP:0000391)2.14560919
59Abnormal ciliary motility (HP:0012262)2.13962943
60Increased corneal curvature (HP:0100692)2.13938362
61Keratoconus (HP:0000563)2.13938362
62Abnormality of the axillary hair (HP:0100134)2.13850072
63Abnormality of secondary sexual hair (HP:0009888)2.13850072
64Progressive inability to walk (HP:0002505)2.12907011
65Fair hair (HP:0002286)2.11227471
66Preaxial foot polydactyly (HP:0001841)2.09827852
67Split foot (HP:0001839)2.09040693
68Polyphagia (HP:0002591)2.08601433
69Hyperthyroidism (HP:0000836)2.07423043
70Congenital stationary night blindness (HP:0007642)2.04700239
71Abnormality of the corticospinal tract (HP:0002492)2.03776365
72Aqueductal stenosis (HP:0002410)2.03233389
73Abnormality of the septum pellucidum (HP:0007375)2.02643777
74Vitreoretinal degeneration (HP:0000655)2.02385942
75Narrow nasal bridge (HP:0000446)2.02362530
76Synostosis involving the elbow (HP:0003938)2.02120179
77Humeroradial synostosis (HP:0003041)2.02120179
78Atelectasis (HP:0100750)2.02063616
79Esotropia (HP:0000565)2.01991894
80Bronchomalacia (HP:0002780)2.01666715
81Aplasia cutis congenita (HP:0001057)2.00459103
82Mutism (HP:0002300)2.00247606
83Abnormal hair whorl (HP:0010721)1.98933743
84Shallow orbits (HP:0000586)1.98419897
85Overriding aorta (HP:0002623)1.96541357
86Gastroesophageal reflux (HP:0002020)1.96371329
87Generalized hypopigmentation of hair (HP:0011358)1.94802729
88Visual hallucinations (HP:0002367)1.94088161
89Morphological abnormality of the middle ear (HP:0008609)1.93336356
90Supranuclear gaze palsy (HP:0000605)1.89888500
91Omphalocele (HP:0001539)1.89468931
92Hyperglycinemia (HP:0002154)1.88421767
93Myelomeningocele (HP:0002475)1.88321250
94Genital tract atresia (HP:0001827)1.87856606
95Congenital primary aphakia (HP:0007707)1.87498855
96Abnormality of the 4th metacarpal (HP:0010012)1.86316583
97Vaginal atresia (HP:0000148)1.86223832
98Renal duplication (HP:0000075)1.84935349
99Choroideremia (HP:0001139)1.84339005
100Broad foot (HP:0001769)1.84257603
101Congenital sensorineural hearing impairment (HP:0008527)1.84232561
102Dysmetria (HP:0001310)1.83798359
103Abnormality of calcium-phosphate metabolism (HP:0100530)1.82873722
104Corneal dystrophy (HP:0001131)1.82694450
105Impaired social interactions (HP:0000735)1.82588448
106Abnormal social behavior (HP:0012433)1.82588448
107Aplasia/Hypoplasia of the sternum (HP:0006714)1.82070410
108Abnormality of the ischium (HP:0003174)1.82063480
109Aplasia/Hypoplasia of the lens (HP:0008063)1.79811429
110Abnormality of the labia minora (HP:0012880)1.79116381
111Alacrima (HP:0000522)1.78870775
112Broad metatarsal (HP:0001783)1.77786603
113Short 4th metacarpal (HP:0010044)1.77211330
114Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.77211330
115Micropenis (HP:0000054)1.76451802
116Partial duplication of thumb phalanx (HP:0009944)1.76105667
117High anterior hairline (HP:0009890)1.75165396
118Labial hypoplasia (HP:0000066)1.75144012
119Nephrogenic diabetes insipidus (HP:0009806)1.74639902
120Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.74495613
121Epileptiform EEG discharges (HP:0011182)1.74090081
122Cutaneous finger syndactyly (HP:0010554)1.72964895
123Truncal ataxia (HP:0002078)1.72007314
124Abnormal eating behavior (HP:0100738)1.71925687
125Absent eyebrow (HP:0002223)1.71910500
126Termporal pattern (HP:0011008)1.70479377
127Insidious onset (HP:0003587)1.70479377
128Bilateral microphthalmos (HP:0007633)1.70120105
129Midline defect of the nose (HP:0004122)1.70113589
130Dental crowding (HP:0000678)1.70034789
131Upper limb muscle weakness (HP:0003484)1.69814984
132Occipital encephalocele (HP:0002085)1.69571908
133Heterochromia iridis (HP:0001100)1.68870258
134Oligodactyly (hands) (HP:0001180)1.68834153
135Oligodactyly (HP:0012165)1.68226766
136White forelock (HP:0002211)1.67963969
137Hemiparesis (HP:0001269)1.67454507
138Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.67230237
139Nonprogressive disorder (HP:0003680)1.66639264
140Abnormal respiratory epithelium morphology (HP:0012253)1.66244844
141Abnormal respiratory motile cilium morphology (HP:0005938)1.66244844
142Specific learning disability (HP:0001328)1.66103596
143Chromosomal breakage induced by crosslinking agents (HP:0003221)1.65842287
144Missing ribs (HP:0000921)1.65184820
145Sleep apnea (HP:0010535)1.64983466
146Xerostomia (HP:0000217)1.64458555
147Aplasia involving bones of the upper limbs (HP:0009823)1.64441806
148Aplasia of the phalanges of the hand (HP:0009802)1.64441806
149Aplasia involving bones of the extremities (HP:0009825)1.64441806
150Tubulointerstitial nephritis (HP:0001970)1.63947954
151Postaxial hand polydactyly (HP:0001162)1.63211848
152Hypoplastic female external genitalia (HP:0012815)1.62655509
153Poor coordination (HP:0002370)1.61518513
154Renovascular hypertension (HP:0100817)1.61514906
155Maternal diabetes (HP:0009800)1.61499094
156Esophageal atresia (HP:0002032)1.60939906
157Broad thumb (HP:0011304)1.60232067
158True hermaphroditism (HP:0010459)1.59957184
159Abnormality of dentin (HP:0010299)1.59624264
160Bicornuate uterus (HP:0000813)1.58814589
161Abnormality of the aortic arch (HP:0012303)1.55477685
162Chorioretinal coloboma (HP:0000567)1.54962291
163Renal dysplasia (HP:0000110)1.54755592
164Vertebral clefting (HP:0008428)1.54111837
165Duplication of thumb phalanx (HP:0009942)1.52468688
166Shawl scrotum (HP:0000049)1.51108435
167Gastrointestinal atresia (HP:0002589)1.50683461
168Broad alveolar ridges (HP:0000187)1.50591269
169Spastic diplegia (HP:0001264)1.50189193
170Abnormality of the antihelix (HP:0009738)1.49750342
171Abnormality of the metopic suture (HP:0005556)1.48921892
172Partial duplication of the phalanx of hand (HP:0009999)1.47754150
173Genetic anticipation (HP:0003743)1.46622176
174Increased nuchal translucency (HP:0010880)1.46115563
175Exercise-induced muscle cramps (HP:0003710)1.45729708
176Mixed hearing impairment (HP:0000410)1.45345901
177Abnormality of the intervertebral disk (HP:0005108)1.43145542
178Elfin facies (HP:0004428)1.43125956
179Generalized hypotonia (HP:0001290)1.41950553

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK7.60536857
2NTRK33.28200369
3TNIK3.12480248
4MARK12.92525591
5EPHA42.77091006
6PRPF4B2.56180718
7PNCK2.44141402
8MAP2K72.25947972
9FGFR22.01099813
10NTRK21.93154872
11CDK191.91077563
12MAPK131.90980134
13PLK21.63610261
14BMPR1B1.55838095
15MAP3K121.53016638
16OXSR11.46586695
17MKNK11.45846762
18ADRBK21.45046182
19SIK21.42909711
20MUSK1.42743191
21BMPR21.42562503
22TSSK61.42384862
23CAMK1G1.39504394
24GRK71.39270831
25SIK31.39154181
26BCR1.33715820
27MAP3K41.33335697
28PDGFRA1.32745023
29BRD41.32728817
30MAP3K101.31799757
31TRIM281.30903672
32NEK61.26784263
33PKN11.26775408
34CSNK1A1L1.26688236
35EIF2AK21.23556455
36DYRK31.15965370
37FES1.15852492
38SRPK11.15424457
39PLK41.13834395
40DAPK21.12672911
41MINK11.10353877
42STK38L1.10007997
43MAP4K21.09835755
44RIPK41.08786004
45CAMK2A1.05902105
46TIE11.05083197
47AKT31.03958999
48PRKD31.03485490
49PRKCE1.02041406
50INSRR1.01161794
51STK391.00423445
52PAK61.00170613
53DYRK1B0.99929260
54TAF10.99790122
55CDK50.99274221
56LIMK10.99143783
57GRK50.98122727
58WEE10.95664903
59CAMK1D0.94734657
60ERBB20.93413944
61YES10.93255578
62CLK10.91163495
63DYRK20.90127858
64LATS10.89834971
65FGR0.89360144
66PLK30.88304587
67ERBB30.86412376
68CAMK2B0.85635631
69MAP3K130.85523296
70CDK30.85195606
71FGFR10.84081006
72TXK0.83951121
73EPHA30.83488594
74MAP3K140.83045033
75NEK20.79834550
76PRKCG0.75831381
77PAK30.74148155
78LATS20.72766398
79UHMK10.72426141
80SGK2230.70344534
81SGK4940.70344534
82MAPK150.69701938
83GRK10.67714085
84ADRBK10.67703829
85MET0.67289793
86TTK0.65268391
87NME10.65032389
88MAP2K40.64526820
89PASK0.62513105
90CDK140.62459217
91DYRK1A0.62243963
92MAPK70.62088274
93DDR20.61960707
94CCNB10.61209319
95STK110.61168115
96NTRK10.60847528
97LMTK20.60837943
98CDK150.60604862
99CDK11A0.58006057
100FRK0.57814016
101SGK20.57704949
102CAMKK20.57148536
103CSNK1G20.56436518
104SGK10.55984208
105MAPK120.55450775
106PHKG20.55392145
107PHKG10.55392145
108MAPKAPK50.55329921
109MAP3K90.54843239
110PTK20.53867560
111DAPK10.53647243
112RPS6KA40.52285909
113IRAK30.51665390
114CAMK10.50873489
115WNK10.50145507
116ERBB40.50065126
117PKN20.48896036
118CAMK2D0.48640691
119BRSK20.48204775
120WNK30.47892395
121PBK0.47845303
122VRK10.47502334
123CSNK1E0.47456392
124ICK0.47281036
125CDK80.46843235
126PLK10.46685995
127KSR10.46366006
128MKNK20.46264614
129CDC70.45692374
130FER0.45339676
131BMX0.42345507
132PDGFRB0.41731016
133EPHB20.41393548
134PRKCH0.39564007
135PRKACA0.39472291
136PIK3CA0.39102983
137PRKDC0.39051018
138IRAK10.38541847
139CSNK1A10.38372516
140STK160.38197037
141CDK10.37729446
142MAPK90.37706871
143RET0.37501511
144CSNK1G30.35971262
145CDK180.35433342
146PRKG10.35429591
147MARK20.34522742
148CSNK1G10.33128951
149ROCK20.32937909
150CAMK40.32338186
151PRKD20.31725393
152TYRO30.31207598
153BRAF0.30226463

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.26369146
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.58402915
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.50002167
4Morphine addiction_Homo sapiens_hsa050322.49769304
5Synaptic vesicle cycle_Homo sapiens_hsa047212.49394833
6Glutamatergic synapse_Homo sapiens_hsa047242.33039518
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.25470995
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.23503779
9Circadian entrainment_Homo sapiens_hsa047132.17332273
10GABAergic synapse_Homo sapiens_hsa047272.10021382
11Taste transduction_Homo sapiens_hsa047422.05807401
12Serotonergic synapse_Homo sapiens_hsa047262.04905144
13Olfactory transduction_Homo sapiens_hsa047401.94290885
14Amphetamine addiction_Homo sapiens_hsa050311.89438654
15Collecting duct acid secretion_Homo sapiens_hsa049661.88061554
16Hippo signaling pathway_Homo sapiens_hsa043901.85198200
17Axon guidance_Homo sapiens_hsa043601.81182286
18Salivary secretion_Homo sapiens_hsa049701.75400353
19Phototransduction_Homo sapiens_hsa047441.73278947
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68735794
21Long-term depression_Homo sapiens_hsa047301.61333962
22Dopaminergic synapse_Homo sapiens_hsa047281.60958709
23Calcium signaling pathway_Homo sapiens_hsa040201.60779604
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.58244678
25Propanoate metabolism_Homo sapiens_hsa006401.56388810
26Cocaine addiction_Homo sapiens_hsa050301.55795170
27Long-term potentiation_Homo sapiens_hsa047201.53076994
28Cholinergic synapse_Homo sapiens_hsa047251.46181941
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.45527313
30Renin secretion_Homo sapiens_hsa049241.43249509
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.43222572
32Butanoate metabolism_Homo sapiens_hsa006501.42873531
33Oxidative phosphorylation_Homo sapiens_hsa001901.42429195
34Protein export_Homo sapiens_hsa030601.41721664
35Insulin secretion_Homo sapiens_hsa049111.40987504
36Adherens junction_Homo sapiens_hsa045201.38712200
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.38441693
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.38118140
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37382624
40Rheumatoid arthritis_Homo sapiens_hsa053231.36464069
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.33834316
42Tight junction_Homo sapiens_hsa045301.25223107
43Notch signaling pathway_Homo sapiens_hsa043301.24663247
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19300580
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14749855
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14728151
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.12409972
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12361164
49Vibrio cholerae infection_Homo sapiens_hsa051101.11877698
50Lysine degradation_Homo sapiens_hsa003101.11580509
51Alzheimers disease_Homo sapiens_hsa050101.09004478
52Oxytocin signaling pathway_Homo sapiens_hsa049211.08874552
53Fatty acid metabolism_Homo sapiens_hsa012121.07815804
54mRNA surveillance pathway_Homo sapiens_hsa030151.07589160
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04669736
56Cysteine and methionine metabolism_Homo sapiens_hsa002701.04035758
57African trypanosomiasis_Homo sapiens_hsa051431.01995831
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00036441
59ErbB signaling pathway_Homo sapiens_hsa040120.99222191
60Type I diabetes mellitus_Homo sapiens_hsa049400.96519774
61Autoimmune thyroid disease_Homo sapiens_hsa053200.95883133
62cAMP signaling pathway_Homo sapiens_hsa040240.94994085
63Biosynthesis of amino acids_Homo sapiens_hsa012300.94497069
64GnRH signaling pathway_Homo sapiens_hsa049120.93834654
65Sphingolipid metabolism_Homo sapiens_hsa006000.92749767
66Cardiac muscle contraction_Homo sapiens_hsa042600.92638632
67Gastric acid secretion_Homo sapiens_hsa049710.92065260
68Melanogenesis_Homo sapiens_hsa049160.90246389
69Spliceosome_Homo sapiens_hsa030400.88639208
70Ovarian steroidogenesis_Homo sapiens_hsa049130.88100224
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87708142
72Arginine and proline metabolism_Homo sapiens_hsa003300.87595954
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87328376
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87273765
75Phagosome_Homo sapiens_hsa041450.86841302
76Gap junction_Homo sapiens_hsa045400.86215885
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85764380
78Pyruvate metabolism_Homo sapiens_hsa006200.84928638
79ECM-receptor interaction_Homo sapiens_hsa045120.84606500
80Colorectal cancer_Homo sapiens_hsa052100.83521049
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83292534
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82918769
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.82780546
84Ether lipid metabolism_Homo sapiens_hsa005650.82287217
85Selenocompound metabolism_Homo sapiens_hsa004500.82258795
86Parkinsons disease_Homo sapiens_hsa050120.82075660
87Ras signaling pathway_Homo sapiens_hsa040140.78659419
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.78202364
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78174647
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78028434
91TGF-beta signaling pathway_Homo sapiens_hsa043500.77198431
92Protein digestion and absorption_Homo sapiens_hsa049740.76724028
93MAPK signaling pathway_Homo sapiens_hsa040100.76225369
94RNA transport_Homo sapiens_hsa030130.75199615
95Oocyte meiosis_Homo sapiens_hsa041140.74286315
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.73979198
97Endometrial cancer_Homo sapiens_hsa052130.73616219
98AMPK signaling pathway_Homo sapiens_hsa041520.72199151
99beta-Alanine metabolism_Homo sapiens_hsa004100.71128294
100Wnt signaling pathway_Homo sapiens_hsa043100.71015451
101Circadian rhythm_Homo sapiens_hsa047100.70893111
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69749924
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69699148
104MicroRNAs in cancer_Homo sapiens_hsa052060.69209005
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.66716145
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66265625
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64692861
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64357285
109Graft-versus-host disease_Homo sapiens_hsa053320.64132403
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63768855
111Base excision repair_Homo sapiens_hsa034100.63705773
112Hedgehog signaling pathway_Homo sapiens_hsa043400.63159386
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62983072
114Allograft rejection_Homo sapiens_hsa053300.62875884
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61154377
116Basal transcription factors_Homo sapiens_hsa030220.61098253
117Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.61035661
118Carbon metabolism_Homo sapiens_hsa012000.60850248
119Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60706280
120Type II diabetes mellitus_Homo sapiens_hsa049300.60686481
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60588697
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60479869
123Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59892757
124Thyroid hormone synthesis_Homo sapiens_hsa049180.58361964
125Inositol phosphate metabolism_Homo sapiens_hsa005620.57893885
126Huntingtons disease_Homo sapiens_hsa050160.56476369
127Dilated cardiomyopathy_Homo sapiens_hsa054140.55769407
128Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55284645
129Choline metabolism in cancer_Homo sapiens_hsa052310.55221938
130Thyroid cancer_Homo sapiens_hsa052160.54528696
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53791092
132Pathways in cancer_Homo sapiens_hsa052000.53109281
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52618404
134Rap1 signaling pathway_Homo sapiens_hsa040150.51831700
135Melanoma_Homo sapiens_hsa052180.51709888
136Peroxisome_Homo sapiens_hsa041460.50297679
137Regulation of autophagy_Homo sapiens_hsa041400.47859609
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.47285707
139RNA degradation_Homo sapiens_hsa030180.47218709
140Basal cell carcinoma_Homo sapiens_hsa052170.46979357
141alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46895417
142Pancreatic secretion_Homo sapiens_hsa049720.46418521
143Chemokine signaling pathway_Homo sapiens_hsa040620.45468162
144Glucagon signaling pathway_Homo sapiens_hsa049220.44592049
145Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44216138
146Arachidonic acid metabolism_Homo sapiens_hsa005900.43876178
147Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43773103
148Estrogen signaling pathway_Homo sapiens_hsa049150.43129725
149Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41421343
150Alcoholism_Homo sapiens_hsa050340.40632247
151Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40028353
152Glioma_Homo sapiens_hsa052140.39849939
153Asthma_Homo sapiens_hsa053100.39580030
154Steroid biosynthesis_Homo sapiens_hsa001000.39457483
155Fatty acid elongation_Homo sapiens_hsa000620.39045525
156Dorso-ventral axis formation_Homo sapiens_hsa043200.37354912
157Malaria_Homo sapiens_hsa051440.35763053

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