PCDHB6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. Unlike the alpha and gamma clusters, the transcripts from these genes do not share common 3' exons. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell neural connections. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)6.32017304
2auditory behavior (GO:0031223)5.54353022
3response to pheromone (GO:0019236)5.20334804
4L-amino acid import (GO:0043092)4.82857641
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.73873279
6vocalization behavior (GO:0071625)4.67349008
7* calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)4.65900289
8response to auditory stimulus (GO:0010996)4.60693228
9locomotory exploration behavior (GO:0035641)4.50833016
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.47932172
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.45366289
12protein localization to synapse (GO:0035418)4.37685919
13mechanosensory behavior (GO:0007638)4.37167589
14regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.30467242
15synaptic vesicle exocytosis (GO:0016079)4.27807818
16regulation of synapse structural plasticity (GO:0051823)4.23969556
17cellular potassium ion homeostasis (GO:0030007)4.21026350
18neuron recognition (GO:0008038)4.10838948
19negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.10409051
20neurotransmitter-gated ion channel clustering (GO:0072578)4.08315642
21positive regulation of synapse maturation (GO:0090129)4.06568074
22dendrite morphogenesis (GO:0048813)4.04777754
23suckling behavior (GO:0001967)4.02458812
24axonal fasciculation (GO:0007413)3.94451398
25presynaptic membrane assembly (GO:0097105)3.93273453
26cerebellar granule cell differentiation (GO:0021707)3.87485780
27dendritic spine morphogenesis (GO:0060997)3.86146932
28positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.85873446
29regulation of glutamate receptor signaling pathway (GO:1900449)3.82217130
30amino acid import (GO:0043090)3.79548978
31positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.73197580
32G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.73027279
33C4-dicarboxylate transport (GO:0015740)3.70458876
34regulation of synaptic transmission, glutamatergic (GO:0051966)3.65485733
35glutamate secretion (GO:0014047)3.64514946
36regulation of synaptic vesicle exocytosis (GO:2000300)3.63411461
37substrate-independent telencephalic tangential migration (GO:0021826)3.59111752
38substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.59111752
39exploration behavior (GO:0035640)3.58696861
40layer formation in cerebral cortex (GO:0021819)3.57647311
41membrane hyperpolarization (GO:0060081)3.57067342
42presynaptic membrane organization (GO:0097090)3.57000307
43bundle of His cell to Purkinje myocyte communication (GO:0086069)3.55492308
44* synapse assembly (GO:0007416)3.54751096
45glutamate receptor signaling pathway (GO:0007215)3.52882595
46synaptic vesicle maturation (GO:0016188)3.50443632
47cell migration in hindbrain (GO:0021535)3.49223359
48ionotropic glutamate receptor signaling pathway (GO:0035235)3.44856326
49negative regulation of cytosolic calcium ion concentration (GO:0051481)3.41847185
50positive regulation of synapse assembly (GO:0051965)3.40986175
51membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.40923371
52synaptic vesicle docking involved in exocytosis (GO:0016081)3.40862382
53postsynaptic membrane organization (GO:0001941)3.40083397
54regulation of synapse maturation (GO:0090128)3.38666423
55neurotransmitter secretion (GO:0007269)3.38317224
56regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.38279716
57neuronal action potential propagation (GO:0019227)3.37055275
58ganglion development (GO:0061548)3.34690235
59positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.33901081
60mating behavior (GO:0007617)3.33060627
61innervation (GO:0060384)3.29661274
62regulation of long-term neuronal synaptic plasticity (GO:0048169)3.29480743
63sodium ion export (GO:0071436)3.29010614
64striatum development (GO:0021756)3.27441016
65regulation of synaptic vesicle transport (GO:1902803)3.27148618
66regulation of neuronal synaptic plasticity (GO:0048168)3.26490399
67pyrimidine nucleobase catabolic process (GO:0006208)3.26337721
68regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.24019400
69gamma-aminobutyric acid transport (GO:0015812)3.21498022
70neuron-neuron synaptic transmission (GO:0007270)3.16620172
71synaptic transmission, glutamatergic (GO:0035249)3.15913656
72regulation of synapse assembly (GO:0051963)3.14859386
73* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)3.14438881
74long-term memory (GO:0007616)3.13381456
75transmission of nerve impulse (GO:0019226)3.11148241
76potassium ion homeostasis (GO:0055075)3.09528210
77cell communication involved in cardiac conduction (GO:0086065)3.09084947
78prepulse inhibition (GO:0060134)3.08172572
79positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.07196049
80regulation of synapse organization (GO:0050807)3.06723900
81long-term synaptic potentiation (GO:0060291)3.06496235
82positive regulation of dendritic spine morphogenesis (GO:0061003)3.05109376
83neurotransmitter transport (GO:0006836)3.05046324
84positive regulation of membrane potential (GO:0045838)3.03186008
85regulation of excitatory postsynaptic membrane potential (GO:0060079)3.02873496
86* synapse organization (GO:0050808)3.02724141
87regulation of postsynaptic membrane potential (GO:0060078)3.02556224
88negative regulation of synaptic transmission, GABAergic (GO:0032229)3.02531418
89cerebral cortex radially oriented cell migration (GO:0021799)3.02209285
90neurotransmitter uptake (GO:0001504)2.97054511
91central nervous system projection neuron axonogenesis (GO:0021952)2.96602964
92protein retention in ER lumen (GO:0006621)2.93175452
93negative regulation of neurotransmitter transport (GO:0051589)2.91078270
94positive regulation of dendritic spine development (GO:0060999)2.91021793
95regulation of voltage-gated calcium channel activity (GO:1901385)2.90279484
96cerebellar Purkinje cell differentiation (GO:0021702)2.89350624
97cell communication by electrical coupling (GO:0010644)2.88601515
98neuromuscular process controlling balance (GO:0050885)2.88308226
99positive regulation of potassium ion transmembrane transport (GO:1901381)2.86858849
100positive regulation of synaptic transmission, GABAergic (GO:0032230)2.86245666
101neuron projection extension involved in neuron projection guidance (GO:1902284)2.85516337
102axon extension involved in axon guidance (GO:0048846)2.85516337
103startle response (GO:0001964)2.84142097
104regulation of cAMP-dependent protein kinase activity (GO:2000479)2.81212374
105detection of light stimulus involved in visual perception (GO:0050908)2.80944502
106detection of light stimulus involved in sensory perception (GO:0050962)2.80944502
107positive regulation of synaptic transmission (GO:0050806)2.80657910
108apical protein localization (GO:0045176)2.80548095
109learning (GO:0007612)2.80161985
110dicarboxylic acid biosynthetic process (GO:0043650)2.79328571
111membrane depolarization (GO:0051899)2.78774658
112axon extension (GO:0048675)2.78750078
113membrane assembly (GO:0071709)2.72779517
114maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.71371737
115growth hormone secretion (GO:0030252)2.70598301
116sympathetic nervous system development (GO:0048485)2.61220774
117membrane budding (GO:0006900)2.58961785
118regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.54669854
119L-serine transport (GO:0015825)2.54643977
120regulation of respiratory system process (GO:0044065)2.54202001
121paraxial mesoderm development (GO:0048339)2.53450098
122* cell-cell adhesion via plasma-membrane adhesion molecules (GO:0098742)2.46893239
123* cell-cell adhesion (GO:0098609)2.46752748
124regulation of vesicle fusion (GO:0031338)2.45859355
125positive regulation of vesicle fusion (GO:0031340)2.45087839
126regulation of respiratory gaseous exchange (GO:0043576)2.43043207
127neuron projection extension (GO:1990138)2.42660365
128auditory receptor cell differentiation (GO:0042491)2.40819731
129adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.35959160
130nerve growth factor signaling pathway (GO:0038180)2.33561553
131desmosome organization (GO:0002934)2.33400240
132response to histamine (GO:0034776)2.31533545
133organelle transport along microtubule (GO:0072384)2.30331594
134hemidesmosome assembly (GO:0031581)2.28296653
135establishment of mitochondrion localization (GO:0051654)2.19695791
136astrocyte differentiation (GO:0048708)2.19383661
137peripheral nervous system development (GO:0007422)2.18939474
138neuromuscular synaptic transmission (GO:0007274)2.18882680
139neuronal stem cell maintenance (GO:0097150)2.18786120
140camera-type eye morphogenesis (GO:0048593)2.18408476
141asymmetric protein localization (GO:0008105)2.18262482
142nonmotile primary cilium assembly (GO:0035058)2.17045875
143neurofilament cytoskeleton organization (GO:0060052)2.16656781
144enteric nervous system development (GO:0048484)2.15881845
145COPI coating of Golgi vesicle (GO:0048205)2.15468909
146Golgi transport vesicle coating (GO:0048200)2.15468909
147short-term memory (GO:0007614)2.14199542
148dendritic spine organization (GO:0097061)2.12091236
149skin morphogenesis (GO:0043589)2.10633744
150lung vasculature development (GO:0060426)2.10080026
151photoreceptor cell differentiation (GO:0046530)2.09466416

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.29156538
2GBX2_23144817_ChIP-Seq_PC3_Human4.12007628
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.70318113
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09697603
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.96266866
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.91053153
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.80069121
8AR_21572438_ChIP-Seq_LNCaP_Human2.59006376
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.50174005
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50036563
11REST_21632747_ChIP-Seq_MESCs_Mouse2.46171271
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45499098
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42653177
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42653177
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.40704719
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.33535641
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30435305
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29667796
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.29023789
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.28020736
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.27251070
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.25500684
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.15744004
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13310391
25TAF15_26573619_Chip-Seq_HEK293_Human2.13249799
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.09963000
27CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09295076
28DROSHA_22980978_ChIP-Seq_HELA_Human1.97376397
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88512625
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.82382244
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.81137014
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76699751
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76268169
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75633255
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73849276
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72947995
37SMAD4_21799915_ChIP-Seq_A2780_Human1.71923478
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71603560
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68935290
40P300_19829295_ChIP-Seq_ESCs_Human1.68824005
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.65947413
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.62113471
43RARB_27405468_Chip-Seq_BRAIN_Mouse1.62008339
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.61172356
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59280369
46WT1_19549856_ChIP-ChIP_CCG9911_Human1.56475780
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53901168
48TRIM28_21343339_ChIP-Seq_HEK293_Human1.50456669
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.50186085
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.48289364
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45661541
52RNF2_27304074_Chip-Seq_NSC_Mouse1.45262470
53STAT3_23295773_ChIP-Seq_U87_Human1.41985078
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40320484
55FUS_26573619_Chip-Seq_HEK293_Human1.39227363
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.39131606
57RING1B_27294783_Chip-Seq_ESCs_Mouse1.38734924
58TCF4_18268006_ChIP-ChIP_LS174T_Human1.38557896
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38224919
60ZNF274_21170338_ChIP-Seq_K562_Hela1.37984071
61PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37405445
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36906898
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32891297
64IGF1R_20145208_ChIP-Seq_DFB_Human1.32243242
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31210648
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29234959
67AR_25329375_ChIP-Seq_VCAP_Human1.28333485
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28109191
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26700980
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25995042
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25788994
72P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21108451
73RING1B_27294783_Chip-Seq_NPCs_Mouse1.20041193
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.19469830
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17685739
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16431837
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16167126
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16122733
79FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15549707
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15366389
81AHR_22903824_ChIP-Seq_MCF-7_Human1.14065527
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14050496
83ZNF263_19887448_ChIP-Seq_K562_Human1.13069909
84AR_19668381_ChIP-Seq_PC3_Human1.12792683
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.12511035
86ISL1_27105846_Chip-Seq_CPCs_Mouse1.12131563
87OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.11067740
88ER_23166858_ChIP-Seq_MCF-7_Human1.10772831
89TP53_18474530_ChIP-ChIP_U2OS_Human1.10716043
90TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10708477
91SMAD_19615063_ChIP-ChIP_OVARY_Human1.09926821
92TCF4_23295773_ChIP-Seq_U87_Human1.09544969
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.09379902
94EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08483156
95CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08260879
96YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07326515
97ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06515117
98WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06039470
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05498744
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05498744
101EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05302932
102TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03554894
103TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03124196
104E2F1_18555785_Chip-Seq_ESCs_Mouse1.02540966
105RUNX2_22187159_ChIP-Seq_PCA_Human1.02172514
106ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01259418
107JUN_21703547_ChIP-Seq_K562_Human1.01068772
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99883869
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99754694
110ERG_21242973_ChIP-ChIP_JURKAT_Human0.99746318
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99616529
112TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98986437
113MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97338350
114TP53_16413492_ChIP-PET_HCT116_Human0.97221925
115CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95207837
116CMYC_18555785_Chip-Seq_ESCs_Mouse0.93894449
117ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93797534
118KDM2B_26808549_Chip-Seq_REH_Human0.93275944
119CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93119972
120CJUN_26792858_Chip-Seq_BT549_Human0.93018742
121STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92421212
122ESR2_21235772_ChIP-Seq_MCF-7_Human0.91425408
123SOX9_26525672_Chip-Seq_HEART_Mouse0.90176916
124RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89967462
125KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.89345515
126SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89257105

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.74064531
2MP0004859_abnormal_synaptic_plasticity4.04836882
3MP0003635_abnormal_synaptic_transmissio3.19689298
4MP0005423_abnormal_somatic_nervous2.90350020
5MP0002063_abnormal_learning/memory/cond2.69257740
6MP0002064_seizures2.69174484
7MP0005645_abnormal_hypothalamus_physiol2.62816957
8MP0001984_abnormal_olfaction2.60399234
9MP0009745_abnormal_behavioral_response2.56174240
10MP0002822_catalepsy2.53484634
11MP0009780_abnormal_chondrocyte_physiolo2.39426145
12MP0001486_abnormal_startle_reflex2.35000414
13MP0003122_maternal_imprinting2.33347309
14MP0005551_abnormal_eye_electrophysiolog2.33267576
15MP0004270_analgesia2.31629267
16MP0010386_abnormal_urinary_bladder2.27678498
17MP0002572_abnormal_emotion/affect_behav2.26183181
18MP0005646_abnormal_pituitary_gland2.19988942
19MP0002272_abnormal_nervous_system2.15067875
20MP0001502_abnormal_circadian_rhythm2.09157007
21MP0002638_abnormal_pupillary_reflex2.08054559
22MP0009046_muscle_twitch2.05631647
23MP0000778_abnormal_nervous_system2.03917880
24MP0002184_abnormal_innervation2.02574239
25MP0006276_abnormal_autonomic_nervous2.01227508
26MP0004858_abnormal_nervous_system2.00146298
27MP0003329_amyloid_beta_deposits1.90086283
28MP0001968_abnormal_touch/_nociception1.86786976
29MP0002090_abnormal_vision1.83816718
30MP0002067_abnormal_sensory_capabilities1.75443889
31MP0001529_abnormal_vocalization1.75224036
32MP0002557_abnormal_social/conspecific_i1.74989763
33MP0001346_abnormal_lacrimal_gland1.69927430
34MP0002734_abnormal_mechanical_nocicepti1.69150958
35MP0003941_abnormal_skin_development1.63439247
36MP0000631_abnormal_neuroendocrine_gland1.62892143
37MP0005248_abnormal_Harderian_gland1.61422087
38MP0004742_abnormal_vestibular_system1.58719649
39MP0005409_darkened_coat_color1.57859701
40MP0004924_abnormal_behavior1.57342016
41MP0005386_behavior/neurological_phenoty1.57342016
42MP0002882_abnormal_neuron_morphology1.50895191
43MP0005253_abnormal_eye_physiology1.48610042
44MP0000955_abnormal_spinal_cord1.48375709
45MP0000013_abnormal_adipose_tissue1.46142880
46MP0001440_abnormal_grooming_behavior1.45206728
47MP0002735_abnormal_chemical_nociception1.44198612
48MP0000579_abnormal_nail_morphology1.36884794
49MP0000566_synostosis1.34380262
50MP0001177_atelectasis1.33581145
51MP0008789_abnormal_olfactory_epithelium1.33069182
52MP0001501_abnormal_sleep_pattern1.32647606
53MP0001970_abnormal_pain_threshold1.31326324
54MP0006072_abnormal_retinal_apoptosis1.30299117
55MP0004133_heterotaxia1.30135082
56MP0002736_abnormal_nociception_after1.28997364
57MP0008569_lethality_at_weaning1.28858407
58MP0000762_abnormal_tongue_morphology1.26263293
59MP0002733_abnormal_thermal_nociception1.25329914
60MP0005171_absent_coat_pigmentation1.25198092
61MP0003633_abnormal_nervous_system1.25056603
62MP0009384_cardiac_valve_regurgitation1.24969515
63MP0005187_abnormal_penis_morphology1.24108665
64MP0003121_genomic_imprinting1.23439674
65MP0002066_abnormal_motor_capabilities/c1.21882379
66MP0004885_abnormal_endolymph1.21547837
67MP0004811_abnormal_neuron_physiology1.21331443
68MP0006292_abnormal_olfactory_placode1.21144322
69MP0003690_abnormal_glial_cell1.19900822
70MP0001905_abnormal_dopamine_level1.19851530
71MP0003183_abnormal_peptide_metabolism1.19849950
72MP0002152_abnormal_brain_morphology1.19827740
73MP0002752_abnormal_somatic_nervous1.19419573
74MP0002229_neurodegeneration1.18872731
75MP0002233_abnormal_nose_morphology1.17275497
76MP0000003_abnormal_adipose_tissue1.17257036
77MP0002653_abnormal_ependyma_morphology1.16522054
78MP0003631_nervous_system_phenotype1.16120809
79MP0010030_abnormal_orbit_morphology1.12834395
80MP0005257_abnormal_intraocular_pressure1.12098557
81MP0000516_abnormal_urinary_system1.11960433
82MP0005367_renal/urinary_system_phenotyp1.11960433
83MP0005623_abnormal_meninges_morphology1.11083788
84MP0001299_abnormal_eye_distance/1.10747892
85MP0000751_myopathy1.10702292
86MP0005195_abnormal_posterior_eye1.09418391
87MP0002938_white_spotting1.08127618
88MP0000920_abnormal_myelination1.08022264
89MP0001188_hyperpigmentation1.08018631
90MP0003011_delayed_dark_adaptation1.06838744
91MP0004272_abnormal_basement_membrane1.05300067
92MP0001270_distended_abdomen1.04849618
93MP0003634_abnormal_glial_cell1.04052443
94MP0004142_abnormal_muscle_tone1.02068660
95MP0003119_abnormal_digestive_system0.97025733
96MP0001963_abnormal_hearing_physiology0.96655314
97MP0008438_abnormal_cutaneous_collagen0.95875637
98MP0004233_abnormal_muscle_weight0.95855358
99MP0003879_abnormal_hair_cell0.95269190
100MP0003755_abnormal_palate_morphology0.94858129
101MP0002234_abnormal_pharynx_morphology0.94181203
102MP0002249_abnormal_larynx_morphology0.94048209
103MP0002909_abnormal_adrenal_gland0.94014163
104MP0004215_abnormal_myocardial_fiber0.93875169
105MP0003890_abnormal_embryonic-extraembry0.93579972
106MP0003632_abnormal_nervous_system0.93551324
107MP0003136_yellow_coat_color0.92343282
108MP0004036_abnormal_muscle_relaxation0.91329542
109MP0008995_early_reproductive_senescence0.91182047
110MP0003861_abnormal_nervous_system0.90886564
111MP0003137_abnormal_impulse_conducting0.90133733
112MP0003942_abnormal_urinary_system0.89544373
113MP0003787_abnormal_imprinting0.88487960
114MP0000639_abnormal_adrenal_gland0.88438715
115MP0002009_preneoplasia0.85124711
116MP0003385_abnormal_body_wall0.84515937
117MP0001324_abnormal_eye_pigmentation0.83864825
118MP0005379_endocrine/exocrine_gland_phen0.83634306
119MP0005394_taste/olfaction_phenotype0.82397757
120MP0005499_abnormal_olfactory_system0.82397757
121MP0005408_hypopigmentation0.81586810
122MP0004085_abnormal_heartbeat0.80861581
123MP0000569_abnormal_digit_pigmentation0.79749927
124MP0002876_abnormal_thyroid_physiology0.79365962
125MP0000604_amyloidosis0.77821715
126MP0000026_abnormal_inner_ear0.77678422
127MP0003283_abnormal_digestive_organ0.77630604
128MP0001664_abnormal_digestion0.77229150
129MP0000534_abnormal_ureter_morphology0.77002068
130MP0001485_abnormal_pinna_reflex0.75589964
131MP0009250_abnormal_appendicular_skeleto0.75328330
132MP0002697_abnormal_eye_size0.74760480
133MP0005595_abnormal_vascular_smooth0.74739390
134MP0002116_abnormal_craniofacial_bone0.73950772
135MP0002751_abnormal_autonomic_nervous0.73087924
136MP0002069_abnormal_eating/drinking_beha0.72910700
137MP0000627_abnormal_mammary_gland0.72624454
138MP0003935_abnormal_craniofacial_develop0.71526150
139MP0000647_abnormal_sebaceous_gland0.71268523
140MP0005197_abnormal_uvea_morphology0.68742791
141MP0003937_abnormal_limbs/digits/tail_de0.68640606

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.36981046
2Myokymia (HP:0002411)5.12392313
3Congenital stationary night blindness (HP:0007642)4.54949568
4Epileptic encephalopathy (HP:0200134)4.14155342
5Polyphagia (HP:0002591)3.97913535
6Drooling (HP:0002307)3.95061535
7Excessive salivation (HP:0003781)3.95061535
8Focal seizures (HP:0007359)3.92793182
9Insidious onset (HP:0003587)3.72048858
10Termporal pattern (HP:0011008)3.72048858
11Hemiparesis (HP:0001269)3.71238100
12Failure to thrive in infancy (HP:0001531)3.70766144
13Hyperventilation (HP:0002883)3.62775875
14Right ventricular cardiomyopathy (HP:0011663)3.49432280
15Progressive inability to walk (HP:0002505)3.42781032
16Febrile seizures (HP:0002373)3.40784050
17Pheochromocytoma (HP:0002666)3.31387537
18Truncal ataxia (HP:0002078)3.29492699
19Action tremor (HP:0002345)3.22836267
20Absence seizures (HP:0002121)3.17174115
21Abnormality of the corticospinal tract (HP:0002492)3.14528476
22Ankle clonus (HP:0011448)3.12732037
23Aqueductal stenosis (HP:0002410)3.10128727
24Abnormal eating behavior (HP:0100738)3.05723044
25Broad-based gait (HP:0002136)3.04188471
26Visual hallucinations (HP:0002367)3.01523673
27Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.98590423
28Degeneration of the lateral corticospinal tracts (HP:0002314)2.98590423
29Generalized tonic-clonic seizures (HP:0002069)2.96776504
30Hemiplegia (HP:0002301)2.94186490
31Spastic gait (HP:0002064)2.87532943
32Central scotoma (HP:0000603)2.87463297
33Blue irides (HP:0000635)2.86910423
34Mutism (HP:0002300)2.84661285
35Abnormality of dentin (HP:0010299)2.83589616
36Atonic seizures (HP:0010819)2.83524129
37Neuroendocrine neoplasm (HP:0100634)2.83422352
38White forelock (HP:0002211)2.79519043
39Epileptiform EEG discharges (HP:0011182)2.77661554
40Septo-optic dysplasia (HP:0100842)2.76731212
41EEG with generalized epileptiform discharges (HP:0011198)2.76136675
42Hypoplasia of the uterus (HP:0000013)2.75776441
43Progressive cerebellar ataxia (HP:0002073)2.75366865
44Abnormality of salivation (HP:0100755)2.73536515
45Neurofibrillary tangles (HP:0002185)2.73233680
46Dialeptic seizures (HP:0011146)2.68992216
47Supranuclear gaze palsy (HP:0000605)2.62672148
48Patchy hypopigmentation of hair (HP:0011365)2.61623812
49Depression (HP:0000716)2.60996533
50Arterial tortuosity (HP:0005116)2.47288321
51Open mouth (HP:0000194)2.45817392
52Premature rupture of membranes (HP:0001788)2.43781768
53Fair hair (HP:0002286)2.41039730
54Sleep apnea (HP:0010535)2.40092188
55Sensory axonal neuropathy (HP:0003390)2.37924201
56Hypsarrhythmia (HP:0002521)2.37141962
57Anteriorly placed anus (HP:0001545)2.29049432
58Inability to walk (HP:0002540)2.28372859
59Hand muscle atrophy (HP:0009130)2.27052248
60Aplasia of the phalanges of the hand (HP:0009802)2.26739229
61Aplasia involving bones of the extremities (HP:0009825)2.26739229
62Aplasia involving bones of the upper limbs (HP:0009823)2.26739229
63Anxiety (HP:0000739)2.24756271
64Hypoplasia of the fovea (HP:0007750)2.23779861
65Aplasia/Hypoplasia of the fovea (HP:0008060)2.23779861
66Narrow forehead (HP:0000341)2.22643894
67Esotropia (HP:0000565)2.22489324
68Limb dystonia (HP:0002451)2.22357967
69Torticollis (HP:0000473)2.21977088
70Cerebral inclusion bodies (HP:0100314)2.21145648
71Ulnar claw (HP:0001178)2.21085383
72Papillary thyroid carcinoma (HP:0002895)2.20940148
73Dysdiadochokinesis (HP:0002075)2.18948228
74Dysmetria (HP:0001310)2.18867677
75Vascular tortuosity (HP:0004948)2.18569905
76Urinary urgency (HP:0000012)2.16942736
77Hypoventilation (HP:0002791)2.16394771
78Heterochromia iridis (HP:0001100)2.16108912
79Lower limb muscle weakness (HP:0007340)2.13818597
80Aplasia/hypoplasia of the uterus (HP:0008684)2.12780086
81Hepatoblastoma (HP:0002884)2.10810826
82Neoplasm of the peripheral nervous system (HP:0100007)2.10798455
83Growth hormone deficiency (HP:0000824)2.10519064
84Abnormality of macular pigmentation (HP:0008002)2.10087375
85Short nail (HP:0001799)2.09390578
86Hyperacusis (HP:0010780)2.09172105
87Adrenal hypoplasia (HP:0000835)2.08873338
88Upper limb muscle weakness (HP:0003484)2.07062627
89Generalized hypopigmentation of hair (HP:0011358)2.06356465
90Focal dystonia (HP:0004373)2.05371188
91Absent speech (HP:0001344)2.03835648
92Poor eye contact (HP:0000817)2.03198483
93Vertebral arch anomaly (HP:0008438)2.03018481
94Protruding tongue (HP:0010808)2.01673593
95Limb-girdle muscle atrophy (HP:0003797)2.00974395
96Abnormality of the labia minora (HP:0012880)1.99427833
97Abnormal hair whorl (HP:0010721)1.98697653
98Split foot (HP:0001839)1.98370681
99Protrusio acetabuli (HP:0003179)1.97827756
100Craniofacial dystonia (HP:0012179)1.97306373
101Absent septum pellucidum (HP:0001331)1.95652265
102Molar tooth sign on MRI (HP:0002419)1.95487445
103Abnormality of midbrain morphology (HP:0002418)1.95487445
104Abnormal social behavior (HP:0012433)1.93358689
105Impaired social interactions (HP:0000735)1.93358689
106Hammertoe (HP:0001765)1.91940308
107Akinesia (HP:0002304)1.91386858
108Hypokinesia (HP:0002375)1.90781486
109Scotoma (HP:0000575)1.90142880
110Urinary bladder sphincter dysfunction (HP:0002839)1.89693159
111Impaired vibration sensation in the lower limbs (HP:0002166)1.89509516
112Widely spaced teeth (HP:0000687)1.89348386
113Paraplegia (HP:0010550)1.88243601
114Spastic paraplegia (HP:0001258)1.87580129
115Infantile muscular hypotonia (HP:0008947)1.86314661
116Renal dysplasia (HP:0000110)1.86072866
117Macroorchidism (HP:0000053)1.84330130
118Upper limb amyotrophy (HP:0009129)1.83743304
119Distal upper limb amyotrophy (HP:0007149)1.83743304
120Stereotypic behavior (HP:0000733)1.83378211
121Exotropia (HP:0000577)1.83375881
122Peripheral hypomyelination (HP:0007182)1.81211654
123Clonus (HP:0002169)1.80751005
124Popliteal pterygium (HP:0009756)1.80598304
125Pulmonary artery stenosis (HP:0004415)1.80590010
126Hypoplastic nipples (HP:0002557)1.80328348
127Neoplasm of the heart (HP:0100544)1.80116824
128Overgrowth (HP:0001548)1.79522651
129Intention tremor (HP:0002080)1.79323812
130Abnormality of the fovea (HP:0000493)1.78909033
131Thickened helices (HP:0000391)1.78735625
132Natal tooth (HP:0000695)1.78674399
133Tented upper lip vermilion (HP:0010804)1.78296434
134Cortical dysplasia (HP:0002539)1.78224108
135Gait imbalance (HP:0002141)1.77964996
136Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.77588230
137Bicornuate uterus (HP:0000813)1.77419972
138Vaginal atresia (HP:0000148)1.76889031
139Shallow orbits (HP:0000586)1.76119348
140Congenital primary aphakia (HP:0007707)1.75012006
141Oligodactyly (HP:0012165)1.72537443
142Pterygium (HP:0001059)1.71994133
143Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.70693086
144Hypoplastic labia majora (HP:0000059)1.69300903
145Genital tract atresia (HP:0001827)1.68742600
146Cutaneous finger syndactyly (HP:0010554)1.68056840
147Synostosis involving the elbow (HP:0003938)1.67944587
148Humeroradial synostosis (HP:0003041)1.67944587
149Thyroid carcinoma (HP:0002890)1.67742868
150Nuclear cataract (HP:0100018)1.65899408
151Turricephaly (HP:0000262)1.65129631
152Exercise-induced muscle cramps (HP:0003710)1.64305601
153Renovascular hypertension (HP:0100817)1.62882668
154Bladder diverticulum (HP:0000015)1.62629080
155Overriding aorta (HP:0002623)1.62279696
156Agitation (HP:0000713)1.61718146
157Insomnia (HP:0100785)1.59199095
158Abnormality of the aortic arch (HP:0012303)1.58840169
159Medial flaring of the eyebrow (HP:0010747)1.58692544
160Nephrogenic diabetes insipidus (HP:0009806)1.58270378
161Entropion (HP:0000621)1.54691752
162Abnormality of the distal phalanges of the toes (HP:0010182)1.52856518
163Advanced eruption of teeth (HP:0006288)1.52704030
164Alacrima (HP:0000522)1.52549768
165Broad face (HP:0000283)1.51797034
166Palpebral edema (HP:0100540)1.51113525
167Elfin facies (HP:0004428)1.49905000
168Neonatal short-limb short stature (HP:0008921)1.48129979
169Atrophic scars (HP:0001075)1.48104752
170Renal hypoplasia (HP:0000089)1.47292730
171Protruding ear (HP:0000411)1.46566401
172Poor suck (HP:0002033)1.45272821
173Diminished movement (HP:0002374)1.45053274
174Labial hypoplasia (HP:0000066)1.45048019
175Hallux valgus (HP:0001822)1.44161453
176Steppage gait (HP:0003376)1.43963855

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.75010810
2MARK13.30245895
3IRAK23.12117127
4TRIM282.88383146
5MINK12.33327674
6MAP3K92.29859020
7EPHA32.29497571
8MAP2K72.21401006
9NTRK32.21388054
10TESK12.14257997
11EPHA42.13403258
12PAK62.10428076
13NTRK22.08412297
14BCR2.01999404
15STK392.01786195
16MAP2K41.98485317
17MET1.97518982
18KSR11.89423375
19PDGFRA1.85594898
20PTK21.82002357
21OXSR11.76170799
22MAP3K121.69457659
23MAP3K41.67120865
24SIK31.64829747
25TNIK1.63919331
26EPHA21.63515563
27IRAK11.56880681
28STK381.56628152
29LATS21.55395664
30LATS11.50675792
31LIMK11.46478948
32ARAF1.46467002
33DYRK1B1.40455789
34PHKG11.32848117
35PHKG21.32848117
36CAMK1G1.32364631
37CDK51.30321047
38MAPK131.28554844
39DAPK21.27315060
40STK38L1.26226996
41WNK11.22930016
42SGK4941.19890321
43SGK2231.19890321
44FGFR21.18046661
45NTRK11.14164230
46FES1.11727281
47CSNK1A1L1.11514314
48CCNB11.10797984
49PKN11.10751498
50MAP3K131.10201579
51MST1R1.09708289
52EPHB21.08891134
53CAMK1D1.08300480
54PRPF4B1.07549238
55PLK21.05214396
56MARK21.04374195
57CDK181.02642308
58SIK10.99894381
59CAMK2B0.97399115
60UHMK10.96992969
61CSNK1G10.96488609
62CAMK2A0.95887353
63CSNK1G30.95732030
64MAPK120.95720989
65CAMK2D0.94100360
66CDK140.92877320
67CDK150.91519831
68ERBB30.88200706
69DDR20.87565862
70PAK30.87443094
71ROCK20.85458911
72FER0.85191981
73DYRK20.85044704
74SGK20.84296149
75RIPK10.83309650
76PRKD20.82491227
77DYRK1A0.81905633
78CAMKK10.81371943
79TAOK10.81246417
80NME10.78022660
81CDK11A0.76249490
82PNCK0.76072095
83SGK10.75992540
84PDGFRB0.75897184
85CDK190.74858139
86PRKCG0.74718835
87RET0.74397527
88MKNK20.72801919
89CLK10.72743506
90MAP4K20.72531572
91TSSK60.72159574
92MAPKAPK50.71203370
93MAP3K10.69901430
94DMPK0.69169635
95MKNK10.68855148
96PRKCE0.68849887
97EPHB10.68553363
98WNK30.67596729
99KSR20.66596888
100FLT30.66122201
101BMPR1B0.65903416
102MUSK0.65470157
103YES10.64359624
104GRK50.63555593
105STK110.61884647
106DYRK30.60966996
107CAMK2G0.59288630
108CSNK1G20.59007255
109PBK0.57046967
110EIF2AK10.56503442
111ERBB40.54193802
112FYN0.54071511
113RPS6KA20.53445667
114SIK20.52673440
115PRKD30.52407247
116CAMK10.51207100
117BRAF0.50825946
118CSNK1E0.50654673
119PINK10.50609887
120SGK30.49943295
121PAK40.49131995
122CDC42BPA0.48962013
123CSNK1A10.48717360
124CDK80.48161142
125PRKCZ0.47551984
126TYRO30.45708137
127PIK3CA0.45556891
128MAP3K20.45477864
129BRD40.44902381
130INSRR0.43004193
131MAP3K110.42969271
132WNK40.41959232
133ICK0.40924424
134NEK60.40172641
135DAPK10.39732012
136BMPR20.39557750
137LMTK20.39131985
138PRKG10.38422525

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.46350952
2Synaptic vesicle cycle_Homo sapiens_hsa047213.27504209
3GABAergic synapse_Homo sapiens_hsa047272.82248124
4Glutamatergic synapse_Homo sapiens_hsa047242.73287344
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.58581303
6Circadian entrainment_Homo sapiens_hsa047132.56049077
7Morphine addiction_Homo sapiens_hsa050322.41107557
8Olfactory transduction_Homo sapiens_hsa047402.40049485
9Dopaminergic synapse_Homo sapiens_hsa047282.11226065
10Serotonergic synapse_Homo sapiens_hsa047262.07126061
11Cholinergic synapse_Homo sapiens_hsa047252.06976494
12Axon guidance_Homo sapiens_hsa043602.04409293
13Collecting duct acid secretion_Homo sapiens_hsa049661.98771627
14Insulin secretion_Homo sapiens_hsa049111.94240723
15Salivary secretion_Homo sapiens_hsa049701.88474914
16Renin secretion_Homo sapiens_hsa049241.82494314
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.79159077
18Amphetamine addiction_Homo sapiens_hsa050311.74328436
19Long-term potentiation_Homo sapiens_hsa047201.71961287
20Long-term depression_Homo sapiens_hsa047301.70169706
21Phototransduction_Homo sapiens_hsa047441.61129283
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56182162
23Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.54160950
24Oxytocin signaling pathway_Homo sapiens_hsa049211.47829926
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45532911
26Cocaine addiction_Homo sapiens_hsa050301.38199018
27Thyroid cancer_Homo sapiens_hsa052161.37649529
28Taste transduction_Homo sapiens_hsa047421.37273977
29Calcium signaling pathway_Homo sapiens_hsa040201.33119624
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32956473
31Steroid biosynthesis_Homo sapiens_hsa001001.32893761
32Gap junction_Homo sapiens_hsa045401.32234220
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30886753
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.30078727
35Gastric acid secretion_Homo sapiens_hsa049711.28962841
36ECM-receptor interaction_Homo sapiens_hsa045121.28364454
37Adherens junction_Homo sapiens_hsa045201.27197280
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.25482334
39Vibrio cholerae infection_Homo sapiens_hsa051101.24210072
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24177678
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21224307
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.20878734
43Cardiac muscle contraction_Homo sapiens_hsa042601.16139435
44GnRH signaling pathway_Homo sapiens_hsa049121.14162104
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09719842
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09253237
47Nitrogen metabolism_Homo sapiens_hsa009101.08466161
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06301440
49Focal adhesion_Homo sapiens_hsa045101.03673021
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01169693
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00646857
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.99489897
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.98754779
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.97294892
55Basal cell carcinoma_Homo sapiens_hsa052170.95639195
56AMPK signaling pathway_Homo sapiens_hsa041520.94620277
57Type II diabetes mellitus_Homo sapiens_hsa049300.94347458
58Dilated cardiomyopathy_Homo sapiens_hsa054140.93277719
59cAMP signaling pathway_Homo sapiens_hsa040240.90509174
60Tight junction_Homo sapiens_hsa045300.89845260
61ErbB signaling pathway_Homo sapiens_hsa040120.89467584
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88522663
63Sulfur metabolism_Homo sapiens_hsa009200.86254876
64Notch signaling pathway_Homo sapiens_hsa043300.86118244
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84156511
66Butanoate metabolism_Homo sapiens_hsa006500.82354419
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82161608
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79484389
69Hedgehog signaling pathway_Homo sapiens_hsa043400.77050707
70Melanogenesis_Homo sapiens_hsa049160.75311026
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73003192
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.71327369
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.70408012
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70396786
75Prion diseases_Homo sapiens_hsa050200.70034489
76Dorso-ventral axis formation_Homo sapiens_hsa043200.68645053
77Pancreatic secretion_Homo sapiens_hsa049720.67835624
78Circadian rhythm_Homo sapiens_hsa047100.67356187
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66351038
80Glioma_Homo sapiens_hsa052140.65405546
81MAPK signaling pathway_Homo sapiens_hsa040100.65338516
82Ras signaling pathway_Homo sapiens_hsa040140.64991385
83Choline metabolism in cancer_Homo sapiens_hsa052310.62849431
84N-Glycan biosynthesis_Homo sapiens_hsa005100.61703444
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60161862
86Endocytosis_Homo sapiens_hsa041440.59110378
87Ether lipid metabolism_Homo sapiens_hsa005650.59007471
88Estrogen signaling pathway_Homo sapiens_hsa049150.58905741
89Oocyte meiosis_Homo sapiens_hsa041140.58564225
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58530157
91Renal cell carcinoma_Homo sapiens_hsa052110.58440647
92Alcoholism_Homo sapiens_hsa050340.57142243
93Ovarian steroidogenesis_Homo sapiens_hsa049130.52453500
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52406097
95PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52264562
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.51676958
97Mineral absorption_Homo sapiens_hsa049780.51471377
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50814142
99Selenocompound metabolism_Homo sapiens_hsa004500.50734589
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49222455
101Endometrial cancer_Homo sapiens_hsa052130.48514957
102Melanoma_Homo sapiens_hsa052180.48016137
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.47844462
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47710622
105Rheumatoid arthritis_Homo sapiens_hsa053230.47289840
106Rap1 signaling pathway_Homo sapiens_hsa040150.46896491
107Oxidative phosphorylation_Homo sapiens_hsa001900.45096047
108Fatty acid elongation_Homo sapiens_hsa000620.44334459
109Thyroid hormone synthesis_Homo sapiens_hsa049180.42749952
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42748867
111TGF-beta signaling pathway_Homo sapiens_hsa043500.42739774
112Colorectal cancer_Homo sapiens_hsa052100.42453025
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42254939
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41124354
115Peroxisome_Homo sapiens_hsa041460.40297171
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40242914
117Phagosome_Homo sapiens_hsa041450.40154714
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.40054751
119Protein digestion and absorption_Homo sapiens_hsa049740.39916398
120Wnt signaling pathway_Homo sapiens_hsa043100.39172069
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37396535
122VEGF signaling pathway_Homo sapiens_hsa043700.37111350
123Insulin signaling pathway_Homo sapiens_hsa049100.35423055
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33943361
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33743446
126Alzheimers disease_Homo sapiens_hsa050100.32828079
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.32534675
128Hippo signaling pathway_Homo sapiens_hsa043900.31938523
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30481778
130Bile secretion_Homo sapiens_hsa049760.30433657
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29821542
132Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28546260
133Glucagon signaling pathway_Homo sapiens_hsa049220.27482885

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