PCDHB7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. The transcript for this particular family member uses more than one polyadenylation site. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.63005940
2presynaptic membrane assembly (GO:0097105)5.52318897
3vocalization behavior (GO:0071625)5.50720685
4neurotransmitter-gated ion channel clustering (GO:0072578)5.36564107
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.34641567
6presynaptic membrane organization (GO:0097090)5.15347828
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.03613346
8cerebellar granule cell differentiation (GO:0021707)4.79841315
9protein localization to synapse (GO:0035418)4.79468207
10synaptic vesicle exocytosis (GO:0016079)4.73529978
11postsynaptic membrane organization (GO:0001941)4.68928646
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.55720936
13regulation of glutamate receptor signaling pathway (GO:1900449)4.45847643
14regulation of synaptic vesicle exocytosis (GO:2000300)4.42877386
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.39384627
16synaptic transmission, glutamatergic (GO:0035249)4.36910292
17glutamate receptor signaling pathway (GO:0007215)4.35522546
18positive regulation of action potential (GO:0045760)4.33526856
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.31973262
20synaptic vesicle docking involved in exocytosis (GO:0016081)4.22139795
21neuron recognition (GO:0008038)4.20038477
22neuron-neuron synaptic transmission (GO:0007270)4.17517369
23axonal fasciculation (GO:0007413)4.11176844
24positive regulation of synapse maturation (GO:0090129)4.06399393
25glutamate secretion (GO:0014047)3.95388971
26startle response (GO:0001964)3.94483603
27regulation of synaptic vesicle transport (GO:1902803)3.94426406
28synaptic vesicle maturation (GO:0016188)3.92816976
29regulation of synapse maturation (GO:0090128)3.87043405
30tachykinin receptor signaling pathway (GO:0007217)3.83787342
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.83462405
32exploration behavior (GO:0035640)3.79533442
33G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.78935600
34nephron tubule development (GO:0072080)3.78420493
35neuronal action potential propagation (GO:0019227)3.75514242
36renal tubule development (GO:0061326)3.74858970
37neurotransmitter secretion (GO:0007269)3.74789790
38regulation of synaptic transmission, glutamatergic (GO:0051966)3.70267488
39dermatan sulfate biosynthetic process (GO:0030208)3.67423466
40positive regulation of synapse assembly (GO:0051965)3.64778991
41negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.63786417
42positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.61231148
43gamma-aminobutyric acid signaling pathway (GO:0007214)3.60556162
44long-term synaptic potentiation (GO:0060291)3.60355259
45negative regulation of synaptic transmission, GABAergic (GO:0032229)3.59201724
46proline transport (GO:0015824)3.57785656
47synaptic vesicle endocytosis (GO:0048488)3.56273588
48gamma-aminobutyric acid transport (GO:0015812)3.49857903
49membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.49288966
50response to histamine (GO:0034776)3.47802005
51behavioral defense response (GO:0002209)3.47508788
52behavioral fear response (GO:0001662)3.47508788
53dermatan sulfate metabolic process (GO:0030205)3.45222059
54locomotory exploration behavior (GO:0035641)3.44765855
55calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.43875294
56long-term memory (GO:0007616)3.39317342
57synapse assembly (GO:0007416)3.34408825
58regulation of neuronal synaptic plasticity (GO:0048168)3.33292753
59regulation of long-term neuronal synaptic plasticity (GO:0048169)3.30133021
60regulation of synapse structural plasticity (GO:0051823)3.26637547
61collecting duct development (GO:0072044)3.26472675
62regulation of excitatory postsynaptic membrane potential (GO:0060079)3.26355659
63transmission of nerve impulse (GO:0019226)3.25184070
64regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.23740398
65fear response (GO:0042596)3.23577732
66behavioral response to nicotine (GO:0035095)3.23230517
67peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.22617733
68pyrimidine nucleobase catabolic process (GO:0006208)3.22052593
69potassium ion homeostasis (GO:0055075)3.21722060
70auditory behavior (GO:0031223)3.19164453
71regulation of postsynaptic membrane potential (GO:0060078)3.17913761
72regulation of glucocorticoid secretion (GO:2000849)3.12756703
73transferrin transport (GO:0033572)3.12529108
74mechanosensory behavior (GO:0007638)3.11890330
75protein heterotrimerization (GO:0070208)3.11045009
76neurotransmitter transport (GO:0006836)3.10836343
77regulation of neurotransmitter secretion (GO:0046928)3.10322108
78nephron epithelium development (GO:0072009)3.09946408
79female mating behavior (GO:0060180)3.08901374
80histone arginine methylation (GO:0034969)3.08543727
81regulation of female receptivity (GO:0045924)3.07075763
82innervation (GO:0060384)3.05564399
83regulation of synaptic transmission, GABAergic (GO:0032228)3.03853648
84metanephric tubule development (GO:0072170)3.03034368
85metanephric nephron tubule development (GO:0072234)3.03034368
86central nervous system projection neuron axonogenesis (GO:0021952)3.02968839
87astrocyte differentiation (GO:0048708)3.02363263
88negative regulation of heart rate (GO:0010459)3.01601437
89regulation of synapse assembly (GO:0051963)2.99528236
90regulation of vesicle fusion (GO:0031338)2.99512134
91phosphate ion homeostasis (GO:0055062)2.98992412
92trivalent inorganic anion homeostasis (GO:0072506)2.98992412
93ferric iron transport (GO:0015682)2.95863788
94trivalent inorganic cation transport (GO:0072512)2.95863788
95regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.95424426
96membrane assembly (GO:0071709)2.94955807
97positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.94895372
98ATP hydrolysis coupled proton transport (GO:0015991)2.94566891
99energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.94566891
100regulation of synaptic plasticity (GO:0048167)2.94406299
101membrane hyperpolarization (GO:0060081)2.94047910
102sympathetic nervous system development (GO:0048485)2.92882399
103limb bud formation (GO:0060174)2.92671934
104negative regulation of dendrite development (GO:2000171)2.91074999
105positive regulation of synaptic transmission, GABAergic (GO:0032230)2.88959467
106positive regulation of membrane potential (GO:0045838)2.88659739
107negative regulation of dendrite morphogenesis (GO:0050774)2.87117515
108synapse organization (GO:0050808)2.85116576
109myoblast fusion (GO:0007520)2.84847563
110learning (GO:0007612)2.84676991
111dendrite development (GO:0016358)2.84606323
112ganglion development (GO:0061548)2.84218961
113negative regulation of cytosolic calcium ion concentration (GO:0051481)2.83847325
114cell differentiation in hindbrain (GO:0021533)2.82779186
115positive regulation of neurotransmitter secretion (GO:0001956)2.82114992
116* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.81343455
117dorsal/ventral axis specification (GO:0009950)2.80921303
118metanephric nephron epithelium development (GO:0072243)2.80621296
119suckling behavior (GO:0001967)2.80014697
120layer formation in cerebral cortex (GO:0021819)2.79310922
121regulation of neurotransmitter transport (GO:0051588)2.79192800
122nucleobase catabolic process (GO:0046113)2.78252771
123positive regulation of synaptic transmission (GO:0050806)2.78095325
124regulation of corticosteroid hormone secretion (GO:2000846)2.77814730
125cerebellar Purkinje cell differentiation (GO:0021702)2.77651416
126dendritic spine morphogenesis (GO:0060997)2.77538794
127membrane depolarization (GO:0051899)2.75523229
128regulation of neurotransmitter levels (GO:0001505)2.75487579
129synaptic transmission (GO:0007268)2.75219243
130axon extension involved in axon guidance (GO:0048846)2.72887624
131neuron projection extension involved in neuron projection guidance (GO:1902284)2.72887624
132regulation of action potential (GO:0098900)2.69560748
133axon extension (GO:0048675)2.65296319
134positive regulation of digestive system process (GO:0060456)2.57277041
135type B pancreatic cell proliferation (GO:0044342)2.56867053
136cellular anion homeostasis (GO:0030002)2.55597713
137protein retention in ER lumen (GO:0006621)2.55491386
138aorta morphogenesis (GO:0035909)2.54134397
139lens morphogenesis in camera-type eye (GO:0002089)2.51843214
140metanephric epithelium development (GO:0072207)2.50164239
141regulation of axon extension involved in axon guidance (GO:0048841)2.44443095
142collagen fibril organization (GO:0030199)2.43283004
143negative regulation of catenin import into nucleus (GO:0035414)2.41706424
144L-glutamate transport (GO:0015813)2.40872958
145acidic amino acid transport (GO:0015800)2.38653839
146chondroitin sulfate catabolic process (GO:0030207)2.37846478
147syncytium formation by plasma membrane fusion (GO:0000768)2.35577166
148cellular response to vitamin D (GO:0071305)2.34405091
149cell differentiation involved in metanephros development (GO:0072202)2.31825019
150cell migration involved in heart development (GO:0060973)2.31742871
151oligosaccharide catabolic process (GO:0009313)2.31036499
152cellular response to vitamin (GO:0071295)2.30587619
153paraxial mesoderm development (GO:0048339)2.28631308
154sphingosine metabolic process (GO:0006670)2.28117205
155retina layer formation (GO:0010842)2.26989726
156camera-type eye morphogenesis (GO:0048593)2.26631914
157regulation of extracellular matrix disassembly (GO:0010715)2.25820206
158maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.25666577
159regulation of respiratory system process (GO:0044065)2.24812881
160glucosamine-containing compound catabolic process (GO:1901072)2.24760210
161regulation of axon guidance (GO:1902667)2.22660965
162extracellular fibril organization (GO:0043206)2.21616367
163limb development (GO:0060173)2.20383069
164appendage development (GO:0048736)2.20383069
165neuronal ion channel clustering (GO:0045161)2.20028133
166peripheral nervous system axon ensheathment (GO:0032292)2.19739433
167myelination in peripheral nervous system (GO:0022011)2.19739433
168* cell-cell adhesion via plasma-membrane adhesion molecules (GO:0098742)2.18906592
169* cell-cell adhesion (GO:0098609)2.18279185
170dendrite morphogenesis (GO:0048813)2.16075092
171axis elongation (GO:0003401)2.15639305
172negative chemotaxis (GO:0050919)2.13614972
173cell fate commitment involved in formation of primary germ layer (GO:0060795)2.12184848
174toxin metabolic process (GO:0009404)2.12020303
175sensory perception of pain (GO:0019233)2.11962657
176response to gravity (GO:0009629)2.11210327
177negative regulation of chondrocyte differentiation (GO:0032331)2.10699105

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.18966139
2GBX2_23144817_ChIP-Seq_PC3_Human4.40447588
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.00197515
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.87830203
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.70953369
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.65090554
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.56219394
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53156876
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.52750756
10TAF15_26573619_Chip-Seq_HEK293_Human2.49067728
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42593295
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42593295
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.39228881
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.38794965
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37880613
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27240331
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.25624524
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.23170034
19REST_21632747_ChIP-Seq_MESCs_Mouse2.18968505
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17292377
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.15273409
22TRIM28_21343339_ChIP-Seq_HEK293_Human2.09431130
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.08146635
24CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07113705
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99450488
26* EZH2_27294783_Chip-Seq_ESCs_Mouse1.96511330
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.95621637
28P300_19829295_ChIP-Seq_ESCs_Human1.94306374
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.92939844
30* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92488005
31SMAD4_21799915_ChIP-Seq_A2780_Human1.91332258
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79162427
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79162261
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.76786575
35DROSHA_22980978_ChIP-Seq_HELA_Human1.74766486
36AR_21572438_ChIP-Seq_LNCaP_Human1.74425315
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74315483
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.72575179
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72110369
40REST_18959480_ChIP-ChIP_MESCs_Mouse1.70796319
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.68028457
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67650147
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.65895214
44FUS_26573619_Chip-Seq_HEK293_Human1.65001212
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.63436508
46RNF2_27304074_Chip-Seq_NSC_Mouse1.62298821
47RARB_27405468_Chip-Seq_BRAIN_Mouse1.61343653
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.61333888
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59096274
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.58958392
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58426220
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.56476939
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53236350
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50109081
55AR_25329375_ChIP-Seq_VCAP_Human1.46295459
56EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46091878
57CJUN_26792858_Chip-Seq_BT549_Human1.45892830
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44639337
59AHR_22903824_ChIP-Seq_MCF-7_Human1.42883902
60ER_23166858_ChIP-Seq_MCF-7_Human1.41495317
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.40225616
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38730926
63WT1_19549856_ChIP-ChIP_CCG9911_Human1.37068696
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.33975692
65WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29943491
66VDR_22108803_ChIP-Seq_LS180_Human1.29036678
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28829031
68NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27901582
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27222955
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25547927
71STAT3_23295773_ChIP-Seq_U87_Human1.25463889
72ZNF274_21170338_ChIP-Seq_K562_Hela1.24157178
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.23856642
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22817343
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22214361
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21200826
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21119427
78JUN_21703547_ChIP-Seq_K562_Human1.19892877
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.19658072
80EWS_26573619_Chip-Seq_HEK293_Human1.19439566
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19076491
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17816792
83TP53_18474530_ChIP-ChIP_U2OS_Human1.15462457
84TCF4_23295773_ChIP-Seq_U87_Human1.15306891
85RUNX2_22187159_ChIP-Seq_PCA_Human1.13898458
86OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13360986
87BCAT_22108803_ChIP-Seq_LS180_Human1.12492804
88YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12424849
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12346745
90NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12346745
91KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12295691
92IGF1R_20145208_ChIP-Seq_DFB_Human1.12065116
93WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11669387
94TP53_20018659_ChIP-ChIP_R1E_Mouse1.11629255
95RXR_22108803_ChIP-Seq_LS180_Human1.10666043
96PRDM14_20953172_ChIP-Seq_ESCs_Human1.09899006
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08918473
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08849142
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08066305
100* RING1B_27294783_Chip-Seq_ESCs_Mouse1.07589216
101LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07453347
102P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07083064
103MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06743230
104PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06546703
105AR_19668381_ChIP-Seq_PC3_Human1.06198040
106FLI1_27457419_Chip-Seq_LIVER_Mouse1.06125832
107STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05797117
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05734594
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05734594
110SOX9_26525672_Chip-Seq_HEART_Mouse1.03926846
111CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03016357
112FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02921110
113VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02111536
114SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01593736
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01082133
116RING1B_27294783_Chip-Seq_NPCs_Mouse1.00421671
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99372663
118E2F1_18555785_Chip-Seq_ESCs_Mouse0.99020257
119MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96983490
120SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.96746807
121CMYC_18555785_Chip-Seq_ESCs_Mouse0.96024256
122CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95779294
123ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95661576
124TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94156504
125EP300_21415370_ChIP-Seq_HL-1_Mouse0.93736812
126TAL1_26923725_Chip-Seq_HPCs_Mouse0.92888354
127TBX3_20139965_ChIP-Seq_ESCs_Mouse0.92877174
128TBX3_20139965_ChIP-Seq_MESCs_Mouse0.92523190

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.98269638
2MP0004859_abnormal_synaptic_plasticity4.92670877
3MP0002822_catalepsy4.26007053
4MP0003635_abnormal_synaptic_transmissio3.54732485
5MP0005503_abnormal_tendon_morphology3.41444629
6MP0009745_abnormal_behavioral_response3.31379751
7MP0008438_abnormal_cutaneous_collagen3.29452686
8MP0002063_abnormal_learning/memory/cond3.07923317
9MP0003787_abnormal_imprinting2.98694285
10MP0002735_abnormal_chemical_nociception2.90915741
11MP0005257_abnormal_intraocular_pressure2.87687317
12MP0002064_seizures2.87203179
13MP0001968_abnormal_touch/_nociception2.76205520
14MP0002572_abnormal_emotion/affect_behav2.68291610
15MP0004270_analgesia2.51017802
16MP0009780_abnormal_chondrocyte_physiolo2.47771822
17MP0009046_muscle_twitch2.47108748
18MP0002272_abnormal_nervous_system2.42549619
19MP0002736_abnormal_nociception_after2.38973998
20MP0006276_abnormal_autonomic_nervous2.34186517
21MP0001188_hyperpigmentation2.24925815
22MP0001501_abnormal_sleep_pattern2.22626490
23MP0005275_abnormal_skin_tensile2.22087148
24MP0000778_abnormal_nervous_system2.14823396
25MP0002734_abnormal_mechanical_nocicepti2.11788522
26MP0001486_abnormal_startle_reflex2.11722106
27MP0005646_abnormal_pituitary_gland2.06067215
28MP0005423_abnormal_somatic_nervous2.05073134
29MP0001958_emphysema2.03049807
30MP0002067_abnormal_sensory_capabilities1.95210010
31MP0003279_aneurysm1.92690833
32MP0002184_abnormal_innervation1.91568113
33MP0001440_abnormal_grooming_behavior1.88878096
34MP0002876_abnormal_thyroid_physiology1.86864881
35MP0001984_abnormal_olfaction1.82889949
36MP0003122_maternal_imprinting1.80963072
37MP0002557_abnormal_social/conspecific_i1.73564127
38MP0002733_abnormal_thermal_nociception1.69892190
39MP0001542_abnormal_bone_strength1.69791920
40MP0001970_abnormal_pain_threshold1.69166614
41MP0004272_abnormal_basement_membrane1.61879998
42MP0002108_abnormal_muscle_morphology1.58797373
43MP0005386_behavior/neurological_phenoty1.55571378
44MP0004924_abnormal_behavior1.55571378
45MP0001529_abnormal_vocalization1.55212848
46MP0005171_absent_coat_pigmentation1.54948783
47MP0004811_abnormal_neuron_physiology1.51401101
48MP0001905_abnormal_dopamine_level1.50196684
49MP0005248_abnormal_Harderian_gland1.49600140
50MP0005623_abnormal_meninges_morphology1.42840327
51MP0008569_lethality_at_weaning1.42439739
52MP0002896_abnormal_bone_mineralization1.38698217
53MP0000569_abnormal_digit_pigmentation1.37494252
54MP0000749_muscle_degeneration1.37076819
55MP0000534_abnormal_ureter_morphology1.36032967
56MP0002882_abnormal_neuron_morphology1.34633661
57MP0010030_abnormal_orbit_morphology1.34013305
58MP0003879_abnormal_hair_cell1.33858486
59MP0000462_abnormal_digestive_system1.28275739
60MP0009384_cardiac_valve_regurgitation1.27591198
61MP0000427_abnormal_hair_cycle1.27317005
62MP0005508_abnormal_skeleton_morphology1.27232965
63MP0004142_abnormal_muscle_tone1.26366523
64MP0010386_abnormal_urinary_bladder1.26100587
65MP0000955_abnormal_spinal_cord1.25469157
66MP0002066_abnormal_motor_capabilities/c1.23662148
67MP0010368_abnormal_lymphatic_system1.23611415
68MP0001177_atelectasis1.22678104
69MP0005645_abnormal_hypothalamus_physiol1.19364593
70MP0004233_abnormal_muscle_weight1.18697104
71MP0003121_genomic_imprinting1.15334576
72MP0004858_abnormal_nervous_system1.14450733
73MP0005551_abnormal_eye_electrophysiolog1.12866961
74MP0003283_abnormal_digestive_organ1.10142625
75MP0001299_abnormal_eye_distance/1.09793002
76MP0003705_abnormal_hypodermis_morpholog1.09259421
77MP0001502_abnormal_circadian_rhythm1.07773346
78MP0004885_abnormal_endolymph1.07689679
79MP0000013_abnormal_adipose_tissue1.06765649
80MP0002751_abnormal_autonomic_nervous1.06311879
81MP0001879_abnormal_lymphatic_vessel1.04695659
82MP0002909_abnormal_adrenal_gland1.04488601
83MP0003942_abnormal_urinary_system1.04010860
84MP0000750_abnormal_muscle_regeneration1.02738348
85MP0002152_abnormal_brain_morphology1.01835125
86MP0004134_abnormal_chest_morphology1.01802237
87MP0000631_abnormal_neuroendocrine_gland1.01290086
88MP0003385_abnormal_body_wall0.99105669
89MP0000538_abnormal_urinary_bladder0.98672293
90MP0003329_amyloid_beta_deposits0.98224067
91MP0003935_abnormal_craniofacial_develop0.98165963
92MP0002090_abnormal_vision0.98096197
93MP0003633_abnormal_nervous_system0.96795185
94MP0002116_abnormal_craniofacial_bone0.93971115
95MP0000767_abnormal_smooth_muscle0.93704346
96MP0005499_abnormal_olfactory_system0.93488393
97MP0005394_taste/olfaction_phenotype0.93488393
98MP0006292_abnormal_olfactory_placode0.93469574
99MP0003137_abnormal_impulse_conducting0.92683140
100MP0001963_abnormal_hearing_physiology0.92561901
101MP0004133_heterotaxia0.91974860
102MP0003937_abnormal_limbs/digits/tail_de0.90972418
103MP0002837_dystrophic_cardiac_calcinosis0.90182977
104MP0000762_abnormal_tongue_morphology0.88960297
105MP0000428_abnormal_craniofacial_morphol0.87561479
106MP0002177_abnormal_outer_ear0.87485381
107MP0004085_abnormal_heartbeat0.87158034
108MP0002752_abnormal_somatic_nervous0.87121703
109MP0002089_abnormal_postnatal_growth/wei0.85421041
110MP0002069_abnormal_eating/drinking_beha0.84892869
111MP0005197_abnormal_uvea_morphology0.82493024
112MP0000163_abnormal_cartilage_morphology0.81928200
113MP0006072_abnormal_retinal_apoptosis0.81246726
114MP0000026_abnormal_inner_ear0.80218768
115MP0003631_nervous_system_phenotype0.80019879
116MP0003755_abnormal_palate_morphology0.79370366
117MP0005409_darkened_coat_color0.79129418
118MP0001849_ear_inflammation0.78146625
119MP0009250_abnormal_appendicular_skeleto0.77711179
120MP0002653_abnormal_ependyma_morphology0.77651650
121MP0002295_abnormal_pulmonary_circulatio0.76385408
122MP0002229_neurodegeneration0.75524544
123MP0008789_abnormal_olfactory_epithelium0.74816170
124MP0002932_abnormal_joint_morphology0.73962398
125MP0005595_abnormal_vascular_smooth0.73492172
126MP0004742_abnormal_vestibular_system0.73083060
127MP0006054_spinal_hemorrhage0.73028443
128MP0000681_abnormal_thyroid_gland0.71085296
129MP0000759_abnormal_skeletal_muscle0.70742046
130MP0003938_abnormal_ear_development0.70525090
131MP0002102_abnormal_ear_morphology0.69476410
132MP0003634_abnormal_glial_cell0.68249703
133MP0002638_abnormal_pupillary_reflex0.68116861
134MP0009379_abnormal_foot_pigmentation0.64804083
135MP0001943_abnormal_respiration0.63317900
136MP0003690_abnormal_glial_cell0.62796433
137MP0001346_abnormal_lacrimal_gland0.60884666
138MP0000049_abnormal_middle_ear0.59118854
139MP0004484_altered_response_of0.59063289
140MP0005253_abnormal_eye_physiology0.56983036
141MP0000751_myopathy0.55762369
142MP0004215_abnormal_myocardial_fiber0.54494109
143MP0003632_abnormal_nervous_system0.54479788
144MP0008877_abnormal_DNA_methylation0.54279070
145MP0010770_preweaning_lethality0.54091924
146MP0002082_postnatal_lethality0.54091924

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.70659467
2Atonic seizures (HP:0010819)5.17339410
3Hyperventilation (HP:0002883)5.09174061
4Focal seizures (HP:0007359)4.94480647
5Epileptic encephalopathy (HP:0200134)4.74963477
6Febrile seizures (HP:0002373)4.56090183
7Abnormal hair whorl (HP:0010721)4.06364423
8Absence seizures (HP:0002121)3.97096048
9Myokymia (HP:0002411)3.93281049
10Broad-based gait (HP:0002136)3.81000028
11Dialeptic seizures (HP:0011146)3.70400981
12Protrusio acetabuli (HP:0003179)3.65085173
13Premature rupture of membranes (HP:0001788)3.61114224
14Drooling (HP:0002307)3.59935300
15Excessive salivation (HP:0003781)3.59935300
16Visual hallucinations (HP:0002367)3.45285804
17Generalized tonic-clonic seizures (HP:0002069)3.35605417
18Progressive cerebellar ataxia (HP:0002073)3.25568153
19Protruding tongue (HP:0010808)3.23989436
20Abnormality of the corticospinal tract (HP:0002492)3.06214634
21Polyphagia (HP:0002591)2.95017549
22Progressive inability to walk (HP:0002505)2.93738447
23Follicular hyperkeratosis (HP:0007502)2.92200590
24Abnormality of the lower motor neuron (HP:0002366)2.86080658
25Gait imbalance (HP:0002141)2.84967287
26Bladder diverticulum (HP:0000015)2.68186815
27Peritonitis (HP:0002586)2.66863656
28Atrophic scars (HP:0001075)2.65638909
29Fetal akinesia sequence (HP:0001989)2.63480727
30Abnormality of dentin (HP:0010299)2.61230614
31Abnormality of salivation (HP:0100755)2.60616923
32Aortic aneurysm (HP:0004942)2.60313676
33Broad metatarsal (HP:0001783)2.59238517
34Inability to walk (HP:0002540)2.58882036
35Blue irides (HP:0000635)2.57878513
36Medial flaring of the eyebrow (HP:0010747)2.54385807
37Protruding ear (HP:0000411)2.53881649
38Poor eye contact (HP:0000817)2.53625635
39Slender build (HP:0001533)2.52830165
40Abnormal eating behavior (HP:0100738)2.51463842
41Aortic dissection (HP:0002647)2.48075954
42Anteriorly placed anus (HP:0001545)2.46281946
43Absent speech (HP:0001344)2.45703417
44Long toe (HP:0010511)2.41946861
45Insidious onset (HP:0003587)2.41367137
46Termporal pattern (HP:0011008)2.41367137
47Amyotrophic lateral sclerosis (HP:0007354)2.40349624
48Ankle contracture (HP:0006466)2.39644812
49Shallow orbits (HP:0000586)2.38872008
50Overgrowth (HP:0001548)2.38175985
51Ulnar claw (HP:0001178)2.36904665
52Narrow nasal bridge (HP:0000446)2.36625564
53Mild short stature (HP:0003502)2.36092373
54Hypoplasia of the brainstem (HP:0002365)2.35419449
55Aplasia/Hypoplasia of the brainstem (HP:0007362)2.35419449
56Bowel diverticulosis (HP:0005222)2.35410122
57Gaze-evoked nystagmus (HP:0000640)2.35128720
58Congenital primary aphakia (HP:0007707)2.34999607
59Amblyopia (HP:0000646)2.34771478
60Epileptiform EEG discharges (HP:0011182)2.34694914
61Short tibia (HP:0005736)2.33209178
62Hyperthyroidism (HP:0000836)2.33164641
63Limb dystonia (HP:0002451)2.32923211
64Shoulder girdle muscle weakness (HP:0003547)2.32922836
65Truncal ataxia (HP:0002078)2.29829162
66Abnormal social behavior (HP:0012433)2.29295101
67Impaired social interactions (HP:0000735)2.29295101
68Inappropriate behavior (HP:0000719)2.27348124
69Vascular tortuosity (HP:0004948)2.26013040
70Sleep apnea (HP:0010535)2.24934596
71Nephrogenic diabetes insipidus (HP:0009806)2.24099415
72Hemiparesis (HP:0001269)2.21795406
73Hypothermia (HP:0002045)2.21421990
74Dynein arm defect of respiratory motile cilia (HP:0012255)2.21093249
75Absent/shortened dynein arms (HP:0200106)2.21093249
76Aplasia/Hypoplasia of the tibia (HP:0005772)2.19264369
77EEG with generalized epileptiform discharges (HP:0011198)2.18016867
78Symphalangism affecting the phalanges of the hand (HP:0009773)2.17899942
79Abnormality of binocular vision (HP:0011514)2.16573434
80Diplopia (HP:0000651)2.16573434
81Urinary bladder sphincter dysfunction (HP:0002839)2.15543916
82Degeneration of the lateral corticospinal tracts (HP:0002314)2.14617246
83Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.14617246
84Wide anterior fontanel (HP:0000260)2.11228218
85Scanning speech (HP:0002168)2.10216323
86Congenital glaucoma (HP:0001087)2.08963570
87Mutism (HP:0002300)2.08519634
88Depression (HP:0000716)2.07401083
89Genital tract atresia (HP:0001827)2.07306373
90Spastic gait (HP:0002064)2.06535214
91Anxiety (HP:0000739)2.05223229
92Genu recurvatum (HP:0002816)2.05071687
93Vaginal atresia (HP:0000148)2.04952811
94Impaired vibration sensation in the lower limbs (HP:0002166)2.04452894
95Buphthalmos (HP:0000557)2.02055680
96Arterial tortuosity (HP:0005116)2.00977302
97Hyperextensible skin (HP:0000974)2.00345633
98Sensory axonal neuropathy (HP:0003390)2.00026140
99Large eyes (HP:0001090)1.97948684
100Vertebral compression fractures (HP:0002953)1.97206153
101Soft skin (HP:0000977)1.96630069
102Turricephaly (HP:0000262)1.96294311
103Abnormal ciliary motility (HP:0012262)1.96266084
104Hypsarrhythmia (HP:0002521)1.96073239
105Poor coordination (HP:0002370)1.95913164
106Coronal craniosynostosis (HP:0004440)1.95902955
107Esotropia (HP:0000565)1.95879505
108Fragile skin (HP:0001030)1.95447720
109Specific learning disability (HP:0001328)1.95270830
110Type 1 muscle fiber predominance (HP:0003803)1.95063332
111Supernumerary nipples (HP:0002558)1.94242171
112Complete atrioventricular canal defect (HP:0001674)1.94203342
113Thyroid-stimulating hormone excess (HP:0002925)1.94090543
114Stereotypic behavior (HP:0000733)1.93701124
115Widely spaced teeth (HP:0000687)1.92884390
116Supernumerary spleens (HP:0009799)1.92265899
117Spinal rigidity (HP:0003306)1.91369139
118Dysostosis multiplex (HP:0000943)1.90594528
119Dysdiadochokinesis (HP:0002075)1.90563228
120Mixed hearing impairment (HP:0000410)1.89004644
121Thickened helices (HP:0000391)1.88574481
122Torticollis (HP:0000473)1.88496486
123Hypoventilation (HP:0002791)1.85336405
124Absent eyebrow (HP:0002223)1.85249464
125Supranuclear gaze palsy (HP:0000605)1.85152764
126Fair hair (HP:0002286)1.83553625
127Akinesia (HP:0002304)1.83137486
128Atrioventricular canal defect (HP:0006695)1.82844193
129Prominent supraorbital ridges (HP:0000336)1.82536563
130Broad ribs (HP:0000885)1.82531284
131Limited hip movement (HP:0008800)1.82431538
132Failure to thrive in infancy (HP:0001531)1.81718004
133Myelomeningocele (HP:0002475)1.81271614
134Pheochromocytoma (HP:0002666)1.80890416
135Dysmetria (HP:0001310)1.80689255
136Joint laxity (HP:0001388)1.80622245
137Diastasis recti (HP:0001540)1.80300496
138Hydroureter (HP:0000072)1.79990588
139Exotropia (HP:0000577)1.79723412
140Lower limb amyotrophy (HP:0007210)1.79478605
141Acute necrotizing encephalopathy (HP:0006965)1.79265666
142Ankle clonus (HP:0011448)1.78270466
143Mesangial abnormality (HP:0001966)1.77423485
144Neuroendocrine neoplasm (HP:0100634)1.76222486
145Biconcave vertebral bodies (HP:0004586)1.76062652
146Pancreatic cysts (HP:0001737)1.75923282
147Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.75704609
148Abnormal mitochondria in muscle tissue (HP:0008316)1.75565257
149Abnormality of the labia minora (HP:0012880)1.75203150
150Generalized hypopigmentation of hair (HP:0011358)1.75018656
151Meningocele (HP:0002435)1.74833423
152Poor suck (HP:0002033)1.74757725
153Neurofibrillary tangles (HP:0002185)1.74719542
154Pulmonic stenosis (HP:0001642)1.74573536
155Oligodactyly (hands) (HP:0001180)1.67038942
156Tibial bowing (HP:0002982)1.66784722
157Mitral regurgitation (HP:0001653)1.66603128
158Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.66106617
159Hip contracture (HP:0003273)1.66053882
160Hip dysplasia (HP:0001385)1.65210826
161Venous insufficiency (HP:0005293)1.64259846
162Thick eyebrow (HP:0000574)1.63426255
163Papilledema (HP:0001085)1.62212399
164Wormian bones (HP:0002645)1.60987697
165Blue sclerae (HP:0000592)1.60257445
166Congenital malformation of the right heart (HP:0011723)1.59462703
167Double outlet right ventricle (HP:0001719)1.59462703
168Wrist flexion contracture (HP:0001239)1.59272000
169Urinary glycosaminoglycan excretion (HP:0003541)1.58851673
170Mucopolysacchariduria (HP:0008155)1.58851673
171Neonatal short-limb short stature (HP:0008921)1.58534939
172Pancreatic fibrosis (HP:0100732)1.58246811
173Hypoplastic ischia (HP:0003175)1.58228220
174Insomnia (HP:0100785)1.58125132
175Aplasia/Hypoplasia of the lens (HP:0008063)1.56966912
176Limb-girdle muscle weakness (HP:0003325)1.56742562
177Abnormality of the phalanges of the 5th finger (HP:0004213)1.56389133
178Osteoarthritis (HP:0002758)1.54843345
179Split foot (HP:0001839)1.54021110
180Hyporeflexia of lower limbs (HP:0002600)1.53508388
181Cerebral aneurysm (HP:0004944)1.53243671
182Infantile muscular hypotonia (HP:0008947)1.53088341
183Heterochromia iridis (HP:0001100)1.53028860
184Renovascular hypertension (HP:0100817)1.52611801
185Abnormality of the middle phalanges of the hand (HP:0009833)1.52512025
186Neonatal respiratory distress (HP:0002643)1.52128231
187Aortic valve stenosis (HP:0001650)1.50406350
188Femoral bowing (HP:0002980)1.49034270
189Oligomenorrhea (HP:0000876)1.48856448
190Abnormality of glycosaminoglycan metabolism (HP:0004371)1.48685012

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.67017072
2NTRK34.96366303
3MARK13.23649451
4EPHA43.14323006
5LIMK13.06992162
6MAP3K122.93720851
7MAP2K72.58026967
8MAP3K42.43626700
9TESK12.40790683
10TNIK2.28269854
11AKT32.16757348
12MAPK132.11014845
13NTRK22.01772953
14MINK11.98582526
15MAP3K61.94143744
16PLK21.92843092
17PRPF4B1.89637204
18PDGFRA1.78086416
19BMPR1B1.66252154
20SGK21.65828265
21EPHA31.64055392
22FRK1.63897859
23STK38L1.58082748
24SGK2231.56192222
25SGK4941.56192222
26DAPK21.56123133
27PTK21.54633983
28PRKD21.50554192
29ERBB31.48747869
30DAPK11.44882061
31MAP2K41.43268956
32DMPK1.42727206
33MAP3K91.36619842
34FGFR21.34688845
35PRKCG1.31568801
36SIK31.30830953
37CAMKK21.29609338
38WNK31.29550848
39DDR21.29267366
40BMPR21.26484159
41TSSK61.26219580
42NUAK11.25234481
43TAF11.24243234
44BCR1.22975981
45ARAF1.22238880
46EPHB11.19216692
47CAMK2A1.18013453
48PAK61.15656769
49PHKG11.13769139
50PHKG21.13769139
51STK31.10576863
52CLK11.09706873
53CAMK2B1.08421488
54OXSR11.07884181
55GRK51.06251446
56CDK51.05348576
57KSR11.04946795
58INSRR1.04838571
59CDK191.04769031
60STK241.01881359
61PRKCE0.99027236
62SGK30.96545796
63CAMKK10.94429252
64LMTK20.94161885
65RIPK40.91054802
66GRK70.90420063
67PKN10.84653020
68NTRK10.80284078
69PIM20.79443582
70PAK30.77986622
71MYLK0.76718752
72DYRK1A0.76468084
73PRKD30.75289831
74NME10.74972339
75GSK3A0.72730467
76UHMK10.72722119
77CSNK1G10.71754953
78SGK10.71155707
79FES0.70647403
80TTN0.70031754
81CSNK1G20.69194348
82YES10.68918091
83PRKD10.68723448
84CDK80.66235042
85CDK30.65968518
86ERBB40.64652173
87RET0.64570738
88PDGFRB0.62902301
89ICK0.62746157
90CCNB10.62616624
91CAMK40.60705591
92NEK60.60490719
93PTK60.60280435
94MUSK0.59339215
95CAMK2D0.58992950
96ERBB20.58979450
97PNCK0.58719372
98PKN20.58340571
99PRKCH0.58257923
100DYRK20.57946861
101CDK180.57529050
102PRKAA10.57243365
103CSNK1A10.57042112
104TRPM70.56814469
105ADRBK20.56653429
106MET0.56373999
107TIE10.55725018
108CSNK1G30.54237114
109CDK140.53655853
110PTK2B0.53213986
111CAMK2G0.52867679
112RPS6KA20.52521045
113TYRO30.50811397
114ADRBK10.50620129
115SIK10.49952115
116PAK20.49948423
117MELK0.49589609
118CDK150.49439933
119CSNK1A1L0.49307487
120MAP2K10.48366330
121LATS20.47979756
122PRKAA20.46202475
123PINK10.45562288
124TRIB30.45541538
125MAPK70.45259581
126SIK20.44826396
127ROCK20.41519068
128STK160.41084723
129RAF10.40551548
130PRKACA0.40508320
131FER0.39820681
132STK380.39647279
133PAK40.39489143
134MAP3K20.39362674
135ABL20.38943859
136EPHA20.38914890
137CDC42BPA0.38867527
138BRAF0.38135617
139PRKG10.37289020
140CDK11A0.37121334
141CAMK10.36891511
142TAOK10.36861613
143PRKCZ0.36741631
144ROCK10.36644244
145RPS6KA30.35876699
146STK110.35660726
147PRKCB0.35226032
148EPHB20.34848174
149PRKCA0.29702244

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.70436851
2Synaptic vesicle cycle_Homo sapiens_hsa047213.71532199
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.03353917
4Collecting duct acid secretion_Homo sapiens_hsa049662.96771434
5GABAergic synapse_Homo sapiens_hsa047272.80938005
6Morphine addiction_Homo sapiens_hsa050322.69117048
7Circadian entrainment_Homo sapiens_hsa047132.65623972
8Olfactory transduction_Homo sapiens_hsa047402.62239435
9Glutamatergic synapse_Homo sapiens_hsa047242.46300336
10Long-term potentiation_Homo sapiens_hsa047202.31079080
11ECM-receptor interaction_Homo sapiens_hsa045122.24863249
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.22567651
13Amphetamine addiction_Homo sapiens_hsa050312.19298308
14Dopaminergic synapse_Homo sapiens_hsa047282.06445989
15Serotonergic synapse_Homo sapiens_hsa047262.04582155
16Taste transduction_Homo sapiens_hsa047422.02956571
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.88525249
18Vibrio cholerae infection_Homo sapiens_hsa051101.84742742
19Cholinergic synapse_Homo sapiens_hsa047251.82683797
20Long-term depression_Homo sapiens_hsa047301.78452128
21Salivary secretion_Homo sapiens_hsa049701.78296158
22Renin secretion_Homo sapiens_hsa049241.73981850
23Insulin secretion_Homo sapiens_hsa049111.71304868
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71272729
25Sphingolipid metabolism_Homo sapiens_hsa006001.60751074
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54180619
27Axon guidance_Homo sapiens_hsa043601.53437619
28Protein export_Homo sapiens_hsa030601.52628706
29Calcium signaling pathway_Homo sapiens_hsa040201.50377788
30Cocaine addiction_Homo sapiens_hsa050301.49692738
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.47460660
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47227671
33Focal adhesion_Homo sapiens_hsa045101.47004639
34Protein digestion and absorption_Homo sapiens_hsa049741.41632381
35Oxidative phosphorylation_Homo sapiens_hsa001901.38444994
36Hippo signaling pathway_Homo sapiens_hsa043901.35959398
37Rheumatoid arthritis_Homo sapiens_hsa053231.35566519
38Gap junction_Homo sapiens_hsa045401.34678349
39Gastric acid secretion_Homo sapiens_hsa049711.32286916
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27905975
41Oxytocin signaling pathway_Homo sapiens_hsa049211.25243956
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.23999202
43Phototransduction_Homo sapiens_hsa047441.16893802
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13908350
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.11282173
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08882698
47Basal cell carcinoma_Homo sapiens_hsa052171.07741464
48cAMP signaling pathway_Homo sapiens_hsa040241.03570648
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03003250
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02429022
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98807276
52GnRH signaling pathway_Homo sapiens_hsa049120.96686003
53Alzheimers disease_Homo sapiens_hsa050100.94764682
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93553255
55Steroid biosynthesis_Homo sapiens_hsa001000.93092665
56Phagosome_Homo sapiens_hsa041450.89351315
57Melanogenesis_Homo sapiens_hsa049160.86078357
58ErbB signaling pathway_Homo sapiens_hsa040120.85413765
59Estrogen signaling pathway_Homo sapiens_hsa049150.84154838
60Glioma_Homo sapiens_hsa052140.84138892
61Cardiac muscle contraction_Homo sapiens_hsa042600.80488757
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79466092
63Parkinsons disease_Homo sapiens_hsa050120.79450505
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78130942
65Tryptophan metabolism_Homo sapiens_hsa003800.77681129
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.76757329
67Tight junction_Homo sapiens_hsa045300.75387738
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.75066453
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74003383
70AMPK signaling pathway_Homo sapiens_hsa041520.73214369
71PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72821618
72Dilated cardiomyopathy_Homo sapiens_hsa054140.71935369
73Type I diabetes mellitus_Homo sapiens_hsa049400.71027056
74Bile secretion_Homo sapiens_hsa049760.69529768
75Ovarian steroidogenesis_Homo sapiens_hsa049130.69182453
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65861324
77Adherens junction_Homo sapiens_hsa045200.65544981
78TGF-beta signaling pathway_Homo sapiens_hsa043500.64948363
79Type II diabetes mellitus_Homo sapiens_hsa049300.62363520
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62025434
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59532466
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58272194
83Proteoglycans in cancer_Homo sapiens_hsa052050.58217743
84Ras signaling pathway_Homo sapiens_hsa040140.57962267
85African trypanosomiasis_Homo sapiens_hsa051430.57913871
86MAPK signaling pathway_Homo sapiens_hsa040100.57491310
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55565780
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55364252
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54409938
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54212698
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53820188
92Ether lipid metabolism_Homo sapiens_hsa005650.51850149
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51521062
94Other glycan degradation_Homo sapiens_hsa005110.51244667
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50357490
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.47321777
97Inositol phosphate metabolism_Homo sapiens_hsa005620.47061539
98Huntingtons disease_Homo sapiens_hsa050160.46897653
99Pathways in cancer_Homo sapiens_hsa052000.46611324
100Alcoholism_Homo sapiens_hsa050340.46441136
101Rap1 signaling pathway_Homo sapiens_hsa040150.46291993
102Circadian rhythm_Homo sapiens_hsa047100.45167455
103Melanoma_Homo sapiens_hsa052180.45108689
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43784807
105Mineral absorption_Homo sapiens_hsa049780.43648042
106Histidine metabolism_Homo sapiens_hsa003400.42302384
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42247004
108Oocyte meiosis_Homo sapiens_hsa041140.40561239
109Wnt signaling pathway_Homo sapiens_hsa043100.40279249
110Amoebiasis_Homo sapiens_hsa051460.39994850
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39614514
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37774500
113Thyroid hormone synthesis_Homo sapiens_hsa049180.37491464
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37348668
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.36772991
116Pancreatic secretion_Homo sapiens_hsa049720.35509218
117Choline metabolism in cancer_Homo sapiens_hsa052310.35279593
118Butanoate metabolism_Homo sapiens_hsa006500.35015701
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32361015
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.32087198
121Sulfur metabolism_Homo sapiens_hsa009200.31355691
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30124120
123Glucagon signaling pathway_Homo sapiens_hsa049220.29796693
124Prion diseases_Homo sapiens_hsa050200.28024573
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.24646559
126Dorso-ventral axis formation_Homo sapiens_hsa043200.24570305
127Chemokine signaling pathway_Homo sapiens_hsa040620.24274452
128Hedgehog signaling pathway_Homo sapiens_hsa043400.23558625
129Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22178241
130Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19360802
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19174230
132Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.18510137
133Colorectal cancer_Homo sapiens_hsa052100.18100447
134Endometrial cancer_Homo sapiens_hsa052130.15495578

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