PCDHGA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of pigment cell differentiation (GO:0050932)6.41862467
2phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.78228505
3regulation of ER to Golgi vesicle-mediated transport (GO:0060628)4.68901047
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.59256657
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.49634433
6locomotory exploration behavior (GO:0035641)4.44201195
7synaptic vesicle maturation (GO:0016188)4.38216692
8dendritic spine morphogenesis (GO:0060997)4.31891242
9synaptic vesicle exocytosis (GO:0016079)4.25667521
10coronary vasculature morphogenesis (GO:0060977)4.07961596
11exploration behavior (GO:0035640)4.02143150
12macroautophagy (GO:0016236)4.01217596
13negative regulation of hormone metabolic process (GO:0032351)4.00737428
14negative regulation of hormone biosynthetic process (GO:0032353)4.00737428
15synaptic vesicle docking involved in exocytosis (GO:0016081)3.98043581
16protein localization to synapse (GO:0035418)3.97616774
17vocalization behavior (GO:0071625)3.91837621
18behavioral response to nicotine (GO:0035095)3.86661772
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.77826824
20L-fucose catabolic process (GO:0042355)3.71424990
21fucose catabolic process (GO:0019317)3.71424990
22L-fucose metabolic process (GO:0042354)3.71424990
23regulation of synaptic vesicle exocytosis (GO:2000300)3.70834310
24detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.69172703
25regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.63215079
26dopamine receptor signaling pathway (GO:0007212)3.59278536
27regulation of glutamate receptor signaling pathway (GO:1900449)3.57373372
28layer formation in cerebral cortex (GO:0021819)3.55174402
29water-soluble vitamin biosynthetic process (GO:0042364)3.55066597
30regulation of ARF protein signal transduction (GO:0032012)3.50979991
31developmental pigmentation (GO:0048066)3.50365088
32indolalkylamine metabolic process (GO:0006586)3.49702585
33regulation of synapse structural plasticity (GO:0051823)3.42645819
34negative regulation of cytosolic calcium ion concentration (GO:0051481)3.41993711
35glutamate secretion (GO:0014047)3.40712398
36behavioral response to ethanol (GO:0048149)3.37990594
37dendrite morphogenesis (GO:0048813)3.32527940
38nonmotile primary cilium assembly (GO:0035058)3.30288544
39neuron cell-cell adhesion (GO:0007158)3.28090239
40response to pheromone (GO:0019236)3.27230152
41detection of light stimulus involved in sensory perception (GO:0050962)3.25239635
42detection of light stimulus involved in visual perception (GO:0050908)3.25239635
43presynaptic membrane assembly (GO:0097105)3.24979747
44pyrimidine nucleobase catabolic process (GO:0006208)3.22813230
45axonal fasciculation (GO:0007413)3.21297355
46C4-dicarboxylate transport (GO:0015740)3.21066594
47cell migration in hindbrain (GO:0021535)3.19766234
48retinal rod cell development (GO:0046548)3.19681508
49reflex (GO:0060004)3.18649675
50piRNA metabolic process (GO:0034587)3.18015479
51cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.17839123
52cell communication by electrical coupling (GO:0010644)3.17234858
53neuronal action potential (GO:0019228)3.16261201
54indole-containing compound catabolic process (GO:0042436)3.15965012
55indolalkylamine catabolic process (GO:0046218)3.15965012
56tryptophan catabolic process (GO:0006569)3.15965012
57glycerophospholipid catabolic process (GO:0046475)3.15523489
58neural tube formation (GO:0001841)3.14661706
59tryptophan metabolic process (GO:0006568)3.14518581
60inner ear receptor stereocilium organization (GO:0060122)3.11479865
61regulation of hippo signaling (GO:0035330)3.10956061
62regulation of synaptic vesicle transport (GO:1902803)3.09392628
63DNA deamination (GO:0045006)3.06904867
64photoreceptor cell maintenance (GO:0045494)3.06431486
65axon cargo transport (GO:0008088)3.05937403
66L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.03486506
67kynurenine metabolic process (GO:0070189)3.02392024
68neurotransmitter secretion (GO:0007269)3.01066292
69acrosome reaction (GO:0007340)3.00378983
70regulation of developmental pigmentation (GO:0048070)2.99182208
71positive regulation of vascular permeability (GO:0043117)2.99005567
72respiratory chain complex IV assembly (GO:0008535)2.97938328
73regulation of hydrogen peroxide-induced cell death (GO:1903205)2.97811727
74regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.97614472
75innervation (GO:0060384)2.97543692
76neuron recognition (GO:0008038)2.96680973
77cornea development in camera-type eye (GO:0061303)2.95378661
78response to misfolded protein (GO:0051788)2.95311762
79cellular ketone body metabolic process (GO:0046950)2.94131120
80presynaptic membrane organization (GO:0097090)2.92300348
81sodium ion export (GO:0071436)2.91158536
82primary amino compound metabolic process (GO:1901160)2.90106571
83mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.88648054
84mitochondrial respiratory chain complex I assembly (GO:0032981)2.88648054
85NADH dehydrogenase complex assembly (GO:0010257)2.88648054
86kidney morphogenesis (GO:0060993)2.88491221
87postsynaptic membrane organization (GO:0001941)2.88190157
88cerebellar granule cell differentiation (GO:0021707)2.86971782
89negative regulation of mast cell activation (GO:0033004)2.86567998
90negative regulation of vascular permeability (GO:0043116)2.85721675
91positive regulation of oligodendrocyte differentiation (GO:0048714)2.85339692
92positive regulation of synapse maturation (GO:0090129)2.85045601
93protein complex biogenesis (GO:0070271)2.83273663
94regulation of hexokinase activity (GO:1903299)2.82746173
95regulation of glucokinase activity (GO:0033131)2.82746173
96regulation of microtubule-based movement (GO:0060632)2.81933194
97nucleoside diphosphate catabolic process (GO:0009134)2.80697175
98indole-containing compound metabolic process (GO:0042430)2.80610673
99dendritic spine organization (GO:0097061)2.80196925
100limb bud formation (GO:0060174)2.79351495
101regulation of vesicle fusion (GO:0031338)2.79292023
102protein K6-linked ubiquitination (GO:0085020)2.79231872
103regulation of action potential (GO:0098900)2.77946802
104DNA double-strand break processing (GO:0000729)2.77921718
105regulation of neuronal synaptic plasticity (GO:0048168)2.77032688
106DNA methylation involved in gamete generation (GO:0043046)2.76301781
107striatum development (GO:0021756)2.75936249
108ionotropic glutamate receptor signaling pathway (GO:0035235)2.75471007
109ubiquinone metabolic process (GO:0006743)2.74609354
110photoreceptor cell development (GO:0042461)2.74365105
111positive regulation of hormone biosynthetic process (GO:0046886)2.74115119
112negative regulation of synaptic transmission, GABAergic (GO:0032229)2.74037352
113activation of protein kinase A activity (GO:0034199)2.73434052
114neurotransmitter-gated ion channel clustering (GO:0072578)2.72975029
115synaptic transmission, glutamatergic (GO:0035249)2.72224796
116cellular potassium ion homeostasis (GO:0030007)2.72050825
117preassembly of GPI anchor in ER membrane (GO:0016254)2.71669141
118vesicle transport along microtubule (GO:0047496)2.71280784
119amino acid salvage (GO:0043102)2.70619179
120L-methionine salvage (GO:0071267)2.70619179
121L-methionine biosynthetic process (GO:0071265)2.70619179
122axoneme assembly (GO:0035082)2.70327526
123cerebellar Purkinje cell layer development (GO:0021680)2.67924293
124regulation of neurotransmitter uptake (GO:0051580)2.67921787
125regulation of long-term neuronal synaptic plasticity (GO:0048169)2.67465011
126ubiquinone biosynthetic process (GO:0006744)2.66630606
127lung lobe morphogenesis (GO:0060463)2.66166938
128protein polyglutamylation (GO:0018095)2.66042984
129glutamate receptor signaling pathway (GO:0007215)2.65570277
130proline transport (GO:0015824)2.65310092
131cilium morphogenesis (GO:0060271)2.65085614
132regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.64763297
133detection of calcium ion (GO:0005513)2.64374798
134serotonin metabolic process (GO:0042428)2.63959857
135regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.63689493
136regulation of meiosis I (GO:0060631)2.63568485
137G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.63221814
138mitochondrial respiratory chain complex assembly (GO:0033108)2.63120141
139membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.62372143
140nucleobase catabolic process (GO:0046113)2.62316631
141inositol phosphate catabolic process (GO:0071545)2.62062974
142neuronal action potential propagation (GO:0019227)2.61776473
143ketone body metabolic process (GO:1902224)2.61500480
144auditory receptor cell stereocilium organization (GO:0060088)2.60840594
145organelle transport along microtubule (GO:0072384)2.60335831
146platelet dense granule organization (GO:0060155)2.59535978
147neuroblast proliferation (GO:0007405)2.59116228
148neurotransmitter transport (GO:0006836)2.58627868
149cytochrome complex assembly (GO:0017004)2.58328739
150protein K11-linked deubiquitination (GO:0035871)2.58026011
151neuromuscular process controlling balance (GO:0050885)2.57927922
152spinal cord motor neuron differentiation (GO:0021522)2.57809698
153positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.57695870
154positive regulation of receptor biosynthetic process (GO:0010870)2.56944743
155startle response (GO:0001964)2.56431891
156negative regulation of telomere maintenance (GO:0032205)2.55897708
157cilium organization (GO:0044782)2.54978197
158central nervous system projection neuron axonogenesis (GO:0021952)2.54258233
159positive regulation of prostaglandin secretion (GO:0032308)2.53834393
160RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.53575473
161regulation of axon extension (GO:0030516)2.53544737
162glycosphingolipid biosynthetic process (GO:0006688)2.52750914
163replication fork processing (GO:0031297)2.51327957
164tachykinin receptor signaling pathway (GO:0007217)2.51230056
165ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.50672622
166gamma-aminobutyric acid transport (GO:0015812)2.50388235
167adenosine metabolic process (GO:0046085)2.49969317
168dopamine transport (GO:0015872)2.49927184
169axon extension (GO:0048675)2.49788018
170synaptic vesicle endocytosis (GO:0048488)2.49074037
171positive regulation of fatty acid transport (GO:2000193)2.47357926
172regulation of cilium movement (GO:0003352)2.45792297
173eye photoreceptor cell development (GO:0042462)2.45731936
174negative regulation of axon extension (GO:0030517)2.45328902
175cilium assembly (GO:0042384)2.45078411
176positive regulation of meiosis (GO:0045836)2.44829060
177misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.44144511
178neuron remodeling (GO:0016322)2.42765333
179retinal cone cell development (GO:0046549)2.42408368
180neuron-neuron synaptic transmission (GO:0007270)2.42197199
181pancreas development (GO:0031016)2.42048261
182retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.41739912
183positive regulation of axon extension (GO:0045773)2.41693462
184recombinational repair (GO:0000725)2.41589126
185neuron projection extension (GO:1990138)2.41536781
186nucleotide transmembrane transport (GO:1901679)2.41221242
187righting reflex (GO:0060013)2.41117698
188synapse assembly (GO:0007416)2.41026587
189gamma-aminobutyric acid signaling pathway (GO:0007214)2.40942236
190protein retention in ER lumen (GO:0006621)2.39705690
191cell differentiation involved in metanephros development (GO:0072202)2.39421033
192long-term synaptic potentiation (GO:0060291)2.39340812

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.56110176
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.35843961
3GBX2_23144817_ChIP-Seq_PC3_Human2.94552879
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.80311763
5IGF1R_20145208_ChIP-Seq_DFB_Human2.74216200
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.72380958
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.58747025
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.57445469
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.55500227
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.51289044
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.46002168
12DROSHA_22980978_ChIP-Seq_HELA_Human2.44756337
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.42858787
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.41835595
15REST_21632747_ChIP-Seq_MESCs_Mouse2.41225933
16AR_21572438_ChIP-Seq_LNCaP_Human2.34683242
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.17114351
18FUS_26573619_Chip-Seq_HEK293_Human2.16952207
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.16486643
20P300_19829295_ChIP-Seq_ESCs_Human2.15622133
21ESR1_20079471_ChIP-ChIP_T-47D_Human2.14630971
22EWS_26573619_Chip-Seq_HEK293_Human2.08441735
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.05356929
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.04015846
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.03209301
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.02753440
27JARID2_20075857_ChIP-Seq_MESCs_Mouse2.01033627
28EZH2_18974828_ChIP-Seq_MESCs_Mouse2.00001507
29RNF2_18974828_ChIP-Seq_MESCs_Mouse2.00001507
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.98390121
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.97439661
32REST_18959480_ChIP-ChIP_MESCs_Mouse1.97371940
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.97233080
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.96499963
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96340178
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.96025245
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.92163325
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.91732468
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89482889
40TAF15_26573619_Chip-Seq_HEK293_Human1.88789704
41ER_23166858_ChIP-Seq_MCF-7_Human1.88247752
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.83246976
43ZNF263_19887448_ChIP-Seq_K562_Human1.76895581
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.76852070
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.67322694
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66237483
47TP53_22573176_ChIP-Seq_HFKS_Human1.63207222
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63145742
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61910419
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.61551146
51MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.61501776
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61176961
53CBP_20019798_ChIP-Seq_JUKART_Human1.59612092
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.59612092
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58287484
56YAP1_20516196_ChIP-Seq_MESCs_Mouse1.57319834
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56812958
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56691802
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.54390483
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53796097
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52101209
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.51927529
63SMAD4_21799915_ChIP-Seq_A2780_Human1.50416256
64KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.49763897
65DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.49615100
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.49114747
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48624433
68* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.48208292
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48006316
70TCF4_23295773_ChIP-Seq_U87_Human1.47898429
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46484160
72BCAT_22108803_ChIP-Seq_LS180_Human1.45994249
73ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.45907336
74GABP_17652178_ChIP-ChIP_JURKAT_Human1.42580849
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.40450589
76RING1B_27294783_Chip-Seq_NPCs_Mouse1.40007729
77NR3C1_23031785_ChIP-Seq_PC12_Mouse1.39503350
78AHR_22903824_ChIP-Seq_MCF-7_Human1.38710647
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.36851587
80AR_19668381_ChIP-Seq_PC3_Human1.36249458
81VDR_22108803_ChIP-Seq_LS180_Human1.35989759
82WT1_25993318_ChIP-Seq_PODOCYTE_Human1.35706500
83ZFP281_18757296_ChIP-ChIP_E14_Mouse1.35272677
84TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34937150
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34706845
86TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33936128
87IRF1_19129219_ChIP-ChIP_H3396_Human1.33106156
88IKZF1_21737484_ChIP-ChIP_HCT116_Human1.32851748
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30542543
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30542543
91TCF4_22108803_ChIP-Seq_LS180_Human1.30486667
92ARNT_22903824_ChIP-Seq_MCF-7_Human1.30327437
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30170189
94ZNF274_21170338_ChIP-Seq_K562_Hela1.29382404
95RING1B_27294783_Chip-Seq_ESCs_Mouse1.29322528
96* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27293795
97MYC_18940864_ChIP-ChIP_HL60_Human1.25755820
98SMAD_19615063_ChIP-ChIP_OVARY_Human1.25563331
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24369974
100RUNX2_22187159_ChIP-Seq_PCA_Human1.24369679
101GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24183113
102NANOG_19829295_ChIP-Seq_ESCs_Human1.23044705
103SOX2_19829295_ChIP-Seq_ESCs_Human1.23044705
104TP53_18474530_ChIP-ChIP_U2OS_Human1.22564484
105SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20087610
106RNF2_27304074_Chip-Seq_NSC_Mouse1.19893410
107FLI1_21867929_ChIP-Seq_TH2_Mouse1.19312281
108EZH2_27294783_Chip-Seq_NPCs_Mouse1.19254722
109KDM2B_26808549_Chip-Seq_K562_Human1.16970204
110PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16696629
111ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16536299
112SMAD4_21741376_ChIP-Seq_EPCs_Human1.15150439
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15074013
114NFE2_27457419_Chip-Seq_LIVER_Mouse1.13776925
115BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13705668
116EST1_17652178_ChIP-ChIP_JURKAT_Human1.13570875
117AR_25329375_ChIP-Seq_VCAP_Human1.12919210
118NANOG_18555785_Chip-Seq_ESCs_Mouse1.12838779
119EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12289120
120NOTCH1_21737748_ChIP-Seq_TLL_Human1.12261113
121ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10956891
122SMAD3_21741376_ChIP-Seq_HESCs_Human1.10068449
123FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09825830
124FOXA1_25329375_ChIP-Seq_VCAP_Human1.09800431
125FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09800431
126TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08869065
127VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08830897
128EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08453982
129ERG_21242973_ChIP-ChIP_JURKAT_Human1.07864115
130DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07837434
131PRDM14_20953172_ChIP-Seq_ESCs_Human1.07482515
132CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07214210
133EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07089904
134OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05879692
135STAT3_23295773_ChIP-Seq_U87_Human1.05317566
136CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04302012
137NCOR_22424771_ChIP-Seq_293T_Human1.04004139
138CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03855947
139SMAD4_21741376_ChIP-Seq_HESCs_Human1.03855052
140RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03558946
141GATA3_21878914_ChIP-Seq_MCF-7_Human1.03526459
142P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03249462
143WT1_19549856_ChIP-ChIP_CCG9911_Human1.03236061
144AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02901222
145NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02184061
146NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02184061
147P53_22387025_ChIP-Seq_ESCs_Mouse1.02013019
148AR_20517297_ChIP-Seq_VCAP_Human1.00781218
149ISL1_27105846_Chip-Seq_CPCs_Mouse1.00525286
150* ELK1_19687146_ChIP-ChIP_HELA_Human1.00419930
151PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00339019
152HOXB7_26014856_ChIP-Seq_BT474_Human1.00233733
153CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00076887
154JUN_21703547_ChIP-Seq_K562_Human0.99075258
155OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98987100
156SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98733428
157E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98157508
158CRX_20693478_ChIP-Seq_RETINA_Mouse0.98062276
159POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97952650
160NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97551382
161ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97217698
162RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97129120
163CDX2_22108803_ChIP-Seq_LS180_Human0.96871977
164BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95621299
165CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95546347
166SALL1_21062744_ChIP-ChIP_HESCs_Human0.94984775
167EGR1_19032775_ChIP-ChIP_M12_Human0.94930172
168TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94342978
169SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92993807

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.16669460
2MP0004859_abnormal_synaptic_plasticity4.57748132
3MP0001188_hyperpigmentation3.86610946
4MP0005409_darkened_coat_color3.84853391
5MP0002102_abnormal_ear_morphology3.20275486
6MP0008877_abnormal_DNA_methylation2.98694466
7MP0004270_analgesia2.89360222
8MP0002837_dystrophic_cardiac_calcinosis2.76031870
9MP0005646_abnormal_pituitary_gland2.75023788
10MP0003635_abnormal_synaptic_transmissio2.64909378
11MP0009780_abnormal_chondrocyte_physiolo2.60807258
12MP0003283_abnormal_digestive_organ2.32521112
13MP0004858_abnormal_nervous_system2.29922607
14MP0002734_abnormal_mechanical_nocicepti2.28438471
15MP0000015_abnormal_ear_pigmentation2.27739707
16MP0002063_abnormal_learning/memory/cond2.23298640
17MP0002909_abnormal_adrenal_gland2.18009414
18MP0002876_abnormal_thyroid_physiology2.01580692
19MP0002064_seizures2.01210256
20MP0008872_abnormal_physiological_respon1.97559806
21MP0001529_abnormal_vocalization1.96261700
22MP0005174_abnormal_tail_pigmentation1.91040095
23MP0001501_abnormal_sleep_pattern1.84605075
24MP0004147_increased_porphyrin_level1.83341531
25MP0000678_abnormal_parathyroid_gland1.82365681
26MP0005645_abnormal_hypothalamus_physiol1.80576904
27MP0000372_irregular_coat_pigmentation1.80064833
28MP0003329_amyloid_beta_deposits1.73777819
29MP0003195_calcinosis1.67055727
30MP0006292_abnormal_olfactory_placode1.65957501
31MP0009046_muscle_twitch1.64629393
32MP0002572_abnormal_emotion/affect_behav1.62533449
33MP0002138_abnormal_hepatobiliary_system1.59896957
34MP0009745_abnormal_behavioral_response1.57986645
35MP0000427_abnormal_hair_cycle1.55542410
36MP0001486_abnormal_startle_reflex1.54469230
37MP0001968_abnormal_touch/_nociception1.52575284
38MP0005084_abnormal_gallbladder_morpholo1.52300394
39MP0004885_abnormal_endolymph1.47976403
40MP0003880_abnormal_central_pattern1.47716974
41MP0009384_cardiac_valve_regurgitation1.46781844
42MP0001986_abnormal_taste_sensitivity1.46409631
43MP0000955_abnormal_spinal_cord1.45653071
44MP0002234_abnormal_pharynx_morphology1.44992734
45MP0002751_abnormal_autonomic_nervous1.44001389
46MP0002938_white_spotting1.42676233
47MP0002249_abnormal_larynx_morphology1.41696271
48MP0002184_abnormal_innervation1.41311491
49MP0000013_abnormal_adipose_tissue1.41158492
50MP0004811_abnormal_neuron_physiology1.39264236
51MP0001299_abnormal_eye_distance/1.38501797
52MP0002272_abnormal_nervous_system1.37342928
53MP0002653_abnormal_ependyma_morphology1.35782121
54MP0004233_abnormal_muscle_weight1.35243782
55MP0003787_abnormal_imprinting1.35136367
56MP0001970_abnormal_pain_threshold1.34895545
57MP0001984_abnormal_olfaction1.34782486
58MP0000778_abnormal_nervous_system1.33996235
59MP0006072_abnormal_retinal_apoptosis1.33508418
60MP0002896_abnormal_bone_mineralization1.32874274
61MP0004043_abnormal_pH_regulation1.31586356
62MP0008875_abnormal_xenobiotic_pharmacok1.29712582
63MP0003172_abnormal_lysosome_physiology1.26626410
64MP0005423_abnormal_somatic_nervous1.24743320
65MP0003646_muscle_fatigue1.24550006
66MP0000049_abnormal_middle_ear1.24302227
67MP0002735_abnormal_chemical_nociception1.18483239
68MP0005623_abnormal_meninges_morphology1.17894462
69MP0000569_abnormal_digit_pigmentation1.17628677
70MP0002882_abnormal_neuron_morphology1.17045691
71MP0002638_abnormal_pupillary_reflex1.16914578
72MP0003011_delayed_dark_adaptation1.15454214
73MP0005551_abnormal_eye_electrophysiolog1.15178373
74MP0002928_abnormal_bile_duct1.14740773
75MP0002733_abnormal_thermal_nociception1.14272840
76MP0001502_abnormal_circadian_rhythm1.14190413
77MP0003252_abnormal_bile_duct1.13194304
78MP0004215_abnormal_myocardial_fiber1.10669815
79MP0001440_abnormal_grooming_behavior1.08708209
80MP0001485_abnormal_pinna_reflex1.08515826
81MP0003634_abnormal_glial_cell1.08298869
82MP0004142_abnormal_muscle_tone1.06702637
83MP0005410_abnormal_fertilization1.06124430
84MP0009697_abnormal_copulation1.05933126
85MP0005379_endocrine/exocrine_gland_phen1.05126024
86MP0003121_genomic_imprinting1.03706153
87MP0002557_abnormal_social/conspecific_i1.03413470
88MP0003879_abnormal_hair_cell1.03403761
89MP0008961_abnormal_basal_metabolism1.00473149
90MP0005394_taste/olfaction_phenotype0.99670109
91MP0005499_abnormal_olfactory_system0.99670109
92MP0005195_abnormal_posterior_eye0.99605807
93MP0002736_abnormal_nociception_after0.98760798
94MP0000631_abnormal_neuroendocrine_gland0.98651665
95MP0005220_abnormal_exocrine_pancreas0.98596656
96MP0004742_abnormal_vestibular_system0.98510935
97MP0003718_maternal_effect0.96583973
98MP0000383_abnormal_hair_follicle0.94519206
99MP0000613_abnormal_salivary_gland0.93776827
100MP0003633_abnormal_nervous_system0.93344950
101MP0008058_abnormal_DNA_repair0.93034358
102MP0003385_abnormal_body_wall0.91827115
103MP0002152_abnormal_brain_morphology0.90255894
104MP0002066_abnormal_motor_capabilities/c0.89551097
105MP0002752_abnormal_somatic_nervous0.89158862
106MP0000681_abnormal_thyroid_gland0.88805838
107MP0001944_abnormal_pancreas_morphology0.88259049
108MP0004130_abnormal_muscle_cell0.87833960
109MP0001764_abnormal_homeostasis0.87205726
110MP0003937_abnormal_limbs/digits/tail_de0.87099920
111MP0008569_lethality_at_weaning0.86854558
112MP0004133_heterotaxia0.86554266
113MP0000751_myopathy0.85772768
114MP0010030_abnormal_orbit_morphology0.85704487
115MP0005076_abnormal_cell_differentiation0.84950418
116MP0005391_vision/eye_phenotype0.84472495
117MP0003136_yellow_coat_color0.84472426
118MP0003137_abnormal_impulse_conducting0.84341432
119MP0003698_abnormal_male_reproductive0.84294637
120MP0004085_abnormal_heartbeat0.83727143
121MP0002090_abnormal_vision0.83657444
122MP0002822_catalepsy0.83493521
123MP0002067_abnormal_sensory_capabilities0.83293461
124MP0005248_abnormal_Harderian_gland0.82731641
125MP0002168_other_aberrant_phenotype0.82247040
126MP0008789_abnormal_olfactory_epithelium0.81701074
127MP0001919_abnormal_reproductive_system0.80723484
128MP0002177_abnormal_outer_ear0.80643728
129MP0003045_fibrosis0.80235514
130MP0005167_abnormal_blood-brain_barrier0.79529618
131MP0001929_abnormal_gametogenesis0.79266382
132MP0010386_abnormal_urinary_bladder0.78932647
133MP0000026_abnormal_inner_ear0.77860552
134MP0003300_gastrointestinal_ulcer0.76808790
135MP0000647_abnormal_sebaceous_gland0.75994861
136MP0008057_abnormal_DNA_replication0.75846462
137MP0008775_abnormal_heart_ventricle0.75713837
138MP0003950_abnormal_plasma_membrane0.75479441
139MP0002163_abnormal_gland_morphology0.75423819
140MP0001963_abnormal_hearing_physiology0.75068209
141MP0003119_abnormal_digestive_system0.74503484
142MP0000003_abnormal_adipose_tissue0.70479569
143MP0005386_behavior/neurological_phenoty0.69983868
144MP0004924_abnormal_behavior0.69983868
145MP0003705_abnormal_hypodermis_morpholog0.68985069
146MP0000604_amyloidosis0.68162659
147MP0003942_abnormal_urinary_system0.67783311
148MP0005253_abnormal_eye_physiology0.66780603
149MP0002229_neurodegeneration0.66100973
150MP0003631_nervous_system_phenotype0.64181973
151MP0002116_abnormal_craniofacial_bone0.64148372
152MP0001348_abnormal_lacrimal_gland0.63452805
153MP0006276_abnormal_autonomic_nervous0.62067605
154MP0005187_abnormal_penis_morphology0.60108497

Predicted human phenotypes

RankGene SetZ-score
1Visual hallucinations (HP:0002367)4.66504155
2Pancreatic cysts (HP:0001737)4.33181704
3Focal motor seizures (HP:0011153)4.18156550
4Pancreatic fibrosis (HP:0100732)4.07655210
5True hermaphroditism (HP:0010459)3.89010229
6Type II lissencephaly (HP:0007260)3.61299556
7Epileptic encephalopathy (HP:0200134)3.51159663
8Pendular nystagmus (HP:0012043)3.45682443
9Congenital stationary night blindness (HP:0007642)3.43240814
10Nephronophthisis (HP:0000090)3.42392164
11Urinary bladder sphincter dysfunction (HP:0002839)3.38978399
12Abnormality of the renal cortex (HP:0011035)3.36178781
13Absent speech (HP:0001344)3.25176154
14Hyperventilation (HP:0002883)3.21850906
15Medial flaring of the eyebrow (HP:0010747)3.21523859
16Abnormality of the renal medulla (HP:0100957)3.19314205
17Myokymia (HP:0002411)3.15313131
18Focal seizures (HP:0007359)3.15272013
19Impaired vibration sensation in the lower limbs (HP:0002166)3.09460237
20Renal cortical cysts (HP:0000803)2.87778525
21Turricephaly (HP:0000262)2.86269511
22Abolished electroretinogram (ERG) (HP:0000550)2.81881079
23Attenuation of retinal blood vessels (HP:0007843)2.78366691
24Abnormality of midbrain morphology (HP:0002418)2.77377589
25Molar tooth sign on MRI (HP:0002419)2.77377589
26Choroideremia (HP:0001139)2.72055815
27Unilateral renal agenesis (HP:0000122)2.70207933
28Cystic liver disease (HP:0006706)2.68620188
29Lower limb asymmetry (HP:0100559)2.64164571
30Shallow orbits (HP:0000586)2.63769085
31Urinary urgency (HP:0000012)2.62205049
32Aplasia/Hypoplasia of the tongue (HP:0010295)2.57847899
33Congenital primary aphakia (HP:0007707)2.54750648
34Metaphyseal cupping (HP:0003021)2.54444488
35Broad-based gait (HP:0002136)2.53811103
36Progressive cerebellar ataxia (HP:0002073)2.52676774
37Sclerocornea (HP:0000647)2.51240591
38Abnormality of the corticospinal tract (HP:0002492)2.50987778
39Occipital encephalocele (HP:0002085)2.50436683
40Keratoconus (HP:0000563)2.50040077
41Increased corneal curvature (HP:0100692)2.50040077
42Hypoplastic nipples (HP:0002557)2.47753099
43Lissencephaly (HP:0001339)2.45448553
44Tubular atrophy (HP:0000092)2.44260965
45Asymmetric growth (HP:0100555)2.42657013
46Missing ribs (HP:0000921)2.42020248
47Labial hypoplasia (HP:0000066)2.41918877
48Lower limb muscle weakness (HP:0007340)2.39552234
49Papilledema (HP:0001085)2.38652347
50Hypothermia (HP:0002045)2.38437220
51Drooling (HP:0002307)2.38040822
52Excessive salivation (HP:0003781)2.38040822
53Pachygyria (HP:0001302)2.37625054
54Action tremor (HP:0002345)2.36631370
55Mitochondrial inheritance (HP:0001427)2.35215465
56Gaze-evoked nystagmus (HP:0000640)2.34480250
57Progressive macrocephaly (HP:0004481)2.33611025
58Agitation (HP:0000713)2.33026091
59Obstructive sleep apnea (HP:0002870)2.32790658
60Large eyes (HP:0001090)2.31535547
61Postaxial foot polydactyly (HP:0001830)2.29340767
62Nephrogenic diabetes insipidus (HP:0009806)2.29310250
63Cerebellar dysplasia (HP:0007033)2.29070665
64Absence seizures (HP:0002121)2.28360504
65Increased CSF lactate (HP:0002490)2.25621653
66Stomach cancer (HP:0012126)2.23865621
67Postural instability (HP:0002172)2.22661183
68Hyperphosphatemia (HP:0002905)2.22474061
69Spastic gait (HP:0002064)2.22289145
70Ankyloglossia (HP:0010296)2.22268310
71Congenital hepatic fibrosis (HP:0002612)2.21740265
72Abnormal rod and cone electroretinograms (HP:0008323)2.21544771
73Abnormal biliary tract physiology (HP:0012439)2.20072927
74Bile duct proliferation (HP:0001408)2.20072927
75Buphthalmos (HP:0000557)2.19394886
76Acute necrotizing encephalopathy (HP:0006965)2.19165777
77Decreased central vision (HP:0007663)2.18892539
78Genital tract atresia (HP:0001827)2.17931105
79Thin ribs (HP:0000883)2.17564398
80Methylmalonic acidemia (HP:0002912)2.16280907
81Gait imbalance (HP:0002141)2.15378619
82Thyroiditis (HP:0100646)2.15258406
83Hypoproteinemia (HP:0003075)2.14997149
84Hyperglycinemia (HP:0002154)2.14927041
85Optic nerve hypoplasia (HP:0000609)2.14623637
86Genetic anticipation (HP:0003743)2.14184635
87Hemiparesis (HP:0001269)2.12902734
88Polydipsia (HP:0001959)2.12373529
89Abnormal drinking behavior (HP:0030082)2.12373529
90Retinal dysplasia (HP:0007973)2.10574072
91Oligodactyly (hands) (HP:0001180)2.10425584
92Disproportionate short-trunk short stature (HP:0003521)2.08794742
93Hepatocellular necrosis (HP:0001404)2.07669717
94Central scotoma (HP:0000603)2.06215179
95Abnormal eating behavior (HP:0100738)2.05676621
96Hyperglycinuria (HP:0003108)2.05571580
97Macroorchidism (HP:0000053)2.04968486
98Progressive inability to walk (HP:0002505)2.04307695
99Anencephaly (HP:0002323)2.03226286
100Hepatic necrosis (HP:0002605)2.02545889
101Ankle clonus (HP:0011448)2.02405851
102Hepatoblastoma (HP:0002884)2.02204558
103Intestinal atresia (HP:0011100)2.02159124
104Hypoplastic female external genitalia (HP:0012815)2.01519182
105Acute encephalopathy (HP:0006846)2.01102542
106Postaxial hand polydactyly (HP:0001162)2.00854451
107Vaginal atresia (HP:0000148)2.00770235
108Generalized tonic-clonic seizures (HP:0002069)1.99199736
109Chronic hepatic failure (HP:0100626)1.97355936
110Abnormality of alanine metabolism (HP:0010916)1.97133392
111Hyperalaninemia (HP:0003348)1.97133392
112Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97133392
113Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96808422
114Inability to walk (HP:0002540)1.96391162
115Congenital sensorineural hearing impairment (HP:0008527)1.96295126
116Dialeptic seizures (HP:0011146)1.96077188
117Febrile seizures (HP:0002373)1.95487356
118Hypoplasia of the pons (HP:0012110)1.93652830
119Cerebral inclusion bodies (HP:0100314)1.93615070
120Abnormality of the pons (HP:0007361)1.93149741
121Abnormality of the astrocytes (HP:0100707)1.91994714
122Astrocytoma (HP:0009592)1.91994714
123Self-mutilation (HP:0000742)1.91605711
124Lipid accumulation in hepatocytes (HP:0006561)1.91121582
12511 pairs of ribs (HP:0000878)1.90732631
126Absent rod-and cone-mediated responses on ERG (HP:0007688)1.90324073
127Hypoplastic labia majora (HP:0000059)1.89372398
128Megalencephaly (HP:0001355)1.89358138
129Neoplasm of the adrenal cortex (HP:0100641)1.88959934
130Amyotrophic lateral sclerosis (HP:0007354)1.88851927
131Split foot (HP:0001839)1.88276437
132Aplasia/Hypoplasia of the tibia (HP:0005772)1.87366474
133Aplasia/hypoplasia of the uterus (HP:0008684)1.87153428
134Narrow nasal bridge (HP:0000446)1.86737142
135Fair hair (HP:0002286)1.86536758
136Bony spicule pigmentary retinopathy (HP:0007737)1.86273802
137Methylmalonic aciduria (HP:0012120)1.85445982
138Neurofibrillary tangles (HP:0002185)1.85395801
139Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.83900034
140Degeneration of the lateral corticospinal tracts (HP:0002314)1.83900034
141Pheochromocytoma (HP:0002666)1.83701067
142Abnormality of macular pigmentation (HP:0008002)1.83592681
143Furrowed tongue (HP:0000221)1.83531701
144Male pseudohermaphroditism (HP:0000037)1.82354485
145Dysdiadochokinesis (HP:0002075)1.80414093
146Pointed chin (HP:0000307)1.80391414
147Hemiplegia (HP:0002301)1.80162794
148Abnormality of serine family amino acid metabolism (HP:0010894)1.79842903
149Abnormality of glycine metabolism (HP:0010895)1.79842903
150Abnormal mitochondria in muscle tissue (HP:0008316)1.79782973
151Large for gestational age (HP:0001520)1.79098777
152Severe muscular hypotonia (HP:0006829)1.78406100
153Anteriorly placed anus (HP:0001545)1.78336155
154Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78304885
155Impaired vibratory sensation (HP:0002495)1.77780619
156Epileptiform EEG discharges (HP:0011182)1.77289716
157Volvulus (HP:0002580)1.76822299
158Chorioretinal atrophy (HP:0000533)1.75544390
159Sex reversal (HP:0012245)1.75330811
160Abnormal sex determination (HP:0012244)1.75330811
161Optic disc pallor (HP:0000543)1.75041451
162Hypsarrhythmia (HP:0002521)1.74441221
163Glioma (HP:0009733)1.74396644
164Ketosis (HP:0001946)1.74360174
165Broad thumb (HP:0011304)1.74219957
166Congenital hip dislocation (HP:0001374)1.74108995
167Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.73731495
168EEG with generalized epileptiform discharges (HP:0011198)1.73614291
169Tubulointerstitial nephritis (HP:0001970)1.73134476
170Abnormality of the labia (HP:0000058)1.73060576
171Depression (HP:0000716)1.72387750
172Increased cerebral lipofuscin (HP:0011813)1.71841289
173Abnormality of the labia majora (HP:0012881)1.71102753
174Rapidly progressive (HP:0003678)1.70811528
175Congenital glaucoma (HP:0001087)1.70521238
176Stereotypic behavior (HP:0000733)1.70130536
177Multiple lipomas (HP:0001012)1.69313896
178Sporadic (HP:0003745)1.69111840
179Supranuclear gaze palsy (HP:0000605)1.68701094
180Facial hemangioma (HP:0000329)1.66781205
181Mutism (HP:0002300)1.66291463
182Abnormality of oral frenula (HP:0000190)1.66014656
183Hypoplasia of the brainstem (HP:0002365)1.65498784
184Aplasia/Hypoplasia of the brainstem (HP:0007362)1.65498784
185Polygenic inheritance (HP:0010982)1.64895430
186Renal duplication (HP:0000075)1.63459203
187Anxiety (HP:0000739)1.63264607
188Torticollis (HP:0000473)1.62869421
189Lower limb amyotrophy (HP:0007210)1.61985420

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.27629306
2MARK14.69646186
3NTRK33.44282832
4BMPR1B3.31682064
5ZAK3.22158428
6MAP4K22.86191068
7WNK32.60173887
8MAP3K92.57658636
9GRK12.55135739
10NUAK12.43366356
11PAK32.43366071
12TLK12.29762721
13PINK12.28954639
14ADRBK22.24260975
15EPHA42.17260913
16TRIB32.15804350
17PAK62.15094547
18EPHA32.00133430
19MINK11.99772356
20ERBB31.93606151
21WNK41.93134756
22CAMKK11.90353054
23BCKDK1.82047453
24EPHB21.80315855
25MAP3K41.79217682
26NTRK21.78663188
27PHKG11.72663070
28PHKG21.72663070
29TAOK31.66186042
30TRIM281.60680947
31STK381.56726219
32ERBB21.54325223
33PKN21.48913624
34PDGFRA1.47798098
35LATS21.46362513
36PRKD31.44832385
37DAPK21.44627530
38SIK21.34552985
39NTRK11.34132060
40MAP2K71.34084371
41ACVR1B1.31138675
42DDR21.30201539
43CDK51.29647213
44OXSR11.29333009
45KSR21.28103982
46MAPKAPK31.27920156
47CSNK1G11.27212162
48MAP2K41.27029041
49STK391.24946347
50VRK11.23969045
51CCNB11.19897113
52CAMKK21.15134167
53CSNK1G31.14963184
54BCR1.13592591
55RET1.13184476
56PNCK1.13136652
57WNK11.12182684
58PRPF4B1.11541435
59PLK21.11493930
60MAP3K21.07573497
61CAMK41.07524544
62PRKCH1.03936363
63MKNK21.02980030
64CDC42BPA1.02912757
65KSR11.02357705
66PRKCG1.01320322
67STK38L0.99688451
68AKT30.98129793
69MAP3K70.95618996
70DAPK10.95300967
71MUSK0.93858552
72CSNK1G20.90657377
73MAPK130.90137736
74ALK0.88426792
75CAMK1G0.87728995
76TGFBR10.87218458
77FER0.87199109
78RPS6KA20.86887785
79NEK10.86473667
80MARK20.85457340
81TIE10.83683659
82SIK10.83650146
83EIF2AK30.82408069
84CASK0.82101415
85DYRK20.81335874
86CDK150.78622313
87TYRO30.77779856
88PRKAA10.77702575
89CDK180.76123000
90TAOK10.73016468
91MAPK90.72036021
92CDK140.70327792
93ADRBK10.69890131
94MST40.68773852
95PKN10.68331312
96SCYL20.68030802
97LMTK20.67863781
98MAPK100.67156008
99PLK30.65635147
100CDK11A0.62907108
101TXK0.62591967
102RPS6KA30.62571681
103SGK30.61699759
104PRKCZ0.61534000
105UHMK10.60634340
106FGFR20.59276122
107PTK2B0.58213988
108INSRR0.57233349
109SGK20.57112475
110CAMK2A0.56981508
111FGFR10.56836041
112SGK2230.55585301
113SGK4940.55585301
114VRK20.54988514
115BRSK20.54895207
116PRKD20.54759134
117FYN0.54361184
118FGFR40.54100301
119CSNK1A10.53362990
120DYRK1A0.53314723
121SRPK10.53063617
122CSNK1A1L0.52500944
123PRKCE0.52154870
124CAMK1D0.52116557
125TEC0.51172256
126MTOR0.50564281
127MAPK80.50079905
128TTN0.49744159
129PIK3CG0.48957808
130CSNK1D0.48313468
131CAMK10.48196744
132SGK10.48193948
133GSK3B0.48032429
134FES0.47778489
135TNIK0.47709572
136TESK10.45939475
137MAPKAPK50.45805651
138GRK50.45546306
139FGFR30.44685205
140RPS6KA50.42617812
141BRD40.42544871
142PLK40.42381876
143CAMK2D0.41207830
144MAP2K10.41009275
145PRKACA0.38005990
146KIT0.36252730
147PRKAA20.34670446
148PDK20.33627051
149ATM0.33594359
150CDK80.33138170
151ATR0.32430259
152MKNK10.31678409
153LATS10.30967852
154STK30.30961074
155PRKCI0.30942045
156PLK10.29891416
157IKBKB0.27265063
158PRKG10.27111753
159TNK20.26950716
160CAMK2B0.26243914

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.21029328
2Butanoate metabolism_Homo sapiens_hsa006502.77697063
3Nicotine addiction_Homo sapiens_hsa050332.66623490
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.54019310
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.49540189
6Circadian entrainment_Homo sapiens_hsa047132.42038102
7Insulin secretion_Homo sapiens_hsa049112.33391979
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.26850438
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.17691600
10GABAergic synapse_Homo sapiens_hsa047272.17450866
11Amphetamine addiction_Homo sapiens_hsa050312.16453299
12Morphine addiction_Homo sapiens_hsa050322.11292225
13Long-term potentiation_Homo sapiens_hsa047202.10370999
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.07860883
15Cholinergic synapse_Homo sapiens_hsa047252.05976341
16Protein export_Homo sapiens_hsa030602.04266872
17Dopaminergic synapse_Homo sapiens_hsa047282.02970051
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02441601
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.99549980
20Linoleic acid metabolism_Homo sapiens_hsa005911.95428712
21Cocaine addiction_Homo sapiens_hsa050301.93029026
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.92033733
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.90047823
24Basal transcription factors_Homo sapiens_hsa030221.89196355
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.87611317
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.85396984
27Glutamatergic synapse_Homo sapiens_hsa047241.80962370
28Propanoate metabolism_Homo sapiens_hsa006401.79193800
29Renin secretion_Homo sapiens_hsa049241.76102748
30Long-term depression_Homo sapiens_hsa047301.72113425
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.71600940
32Tryptophan metabolism_Homo sapiens_hsa003801.70911891
33Selenocompound metabolism_Homo sapiens_hsa004501.69539101
34Oxidative phosphorylation_Homo sapiens_hsa001901.61601887
35Ether lipid metabolism_Homo sapiens_hsa005651.61192035
36Non-homologous end-joining_Homo sapiens_hsa034501.60869931
37Olfactory transduction_Homo sapiens_hsa047401.60296057
38Gap junction_Homo sapiens_hsa045401.57369179
39RNA polymerase_Homo sapiens_hsa030201.53969629
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52987045
41Salivary secretion_Homo sapiens_hsa049701.51332720
42Oxytocin signaling pathway_Homo sapiens_hsa049211.50059142
43Fanconi anemia pathway_Homo sapiens_hsa034601.49893443
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.45239982
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42877351
46Serotonergic synapse_Homo sapiens_hsa047261.41486618
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41437913
48Carbohydrate digestion and absorption_Homo sapiens_hsa049731.39041593
49Sulfur metabolism_Homo sapiens_hsa009201.37090805
50Homologous recombination_Homo sapiens_hsa034401.36031740
51cGMP-PKG signaling pathway_Homo sapiens_hsa040221.35365297
52Gastric acid secretion_Homo sapiens_hsa049711.34856853
53Peroxisome_Homo sapiens_hsa041461.33503117
54Type II diabetes mellitus_Homo sapiens_hsa049301.31424741
55Axon guidance_Homo sapiens_hsa043601.30126470
56GnRH signaling pathway_Homo sapiens_hsa049121.28071972
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21913208
58Parkinsons disease_Homo sapiens_hsa050121.20445328
59Estrogen signaling pathway_Homo sapiens_hsa049151.19104752
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.17727817
61Glioma_Homo sapiens_hsa052141.17520234
62Phototransduction_Homo sapiens_hsa047441.16152695
63Thyroid hormone signaling pathway_Homo sapiens_hsa049191.13804424
64Calcium signaling pathway_Homo sapiens_hsa040201.12552585
65Caffeine metabolism_Homo sapiens_hsa002321.12479136
66Vibrio cholerae infection_Homo sapiens_hsa051101.11410666
67Dilated cardiomyopathy_Homo sapiens_hsa054141.10753671
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09084775
69Melanogenesis_Homo sapiens_hsa049161.08703371
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.05836871
71cAMP signaling pathway_Homo sapiens_hsa040241.05317294
72Collecting duct acid secretion_Homo sapiens_hsa049661.04384702
73beta-Alanine metabolism_Homo sapiens_hsa004101.00783292
74RNA degradation_Homo sapiens_hsa030181.00668065
75mTOR signaling pathway_Homo sapiens_hsa041500.98988453
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98345423
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97120465
78Regulation of autophagy_Homo sapiens_hsa041400.94189599
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93979090
80ErbB signaling pathway_Homo sapiens_hsa040120.93629761
81Steroid biosynthesis_Homo sapiens_hsa001000.93484289
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92780055
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.92350390
84Fatty acid elongation_Homo sapiens_hsa000620.91859925
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89377472
86Nitrogen metabolism_Homo sapiens_hsa009100.89183300
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.89023897
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88609370
89Renal cell carcinoma_Homo sapiens_hsa052110.88544455
90Colorectal cancer_Homo sapiens_hsa052100.88130852
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.85941541
92Chemical carcinogenesis_Homo sapiens_hsa052040.85591620
93One carbon pool by folate_Homo sapiens_hsa006700.85118070
94VEGF signaling pathway_Homo sapiens_hsa043700.83941531
95Endometrial cancer_Homo sapiens_hsa052130.82925955
96Glycerolipid metabolism_Homo sapiens_hsa005610.82427139
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82253134
98Wnt signaling pathway_Homo sapiens_hsa043100.80991279
99Alcoholism_Homo sapiens_hsa050340.80855387
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80554625
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80420208
102Taste transduction_Homo sapiens_hsa047420.79562060
103Fatty acid metabolism_Homo sapiens_hsa012120.79217672
104Glucagon signaling pathway_Homo sapiens_hsa049220.78212216
105Purine metabolism_Homo sapiens_hsa002300.77318498
106Amoebiasis_Homo sapiens_hsa051460.77200437
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76049387
108Huntingtons disease_Homo sapiens_hsa050160.74443534
109Fatty acid biosynthesis_Homo sapiens_hsa000610.73079993
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.72425804
111Retinol metabolism_Homo sapiens_hsa008300.72149244
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71069514
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71069260
114Hedgehog signaling pathway_Homo sapiens_hsa043400.70557566
115Insulin signaling pathway_Homo sapiens_hsa049100.69777170
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69746937
117Ovarian steroidogenesis_Homo sapiens_hsa049130.69601854
118Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.69118385
119Insulin resistance_Homo sapiens_hsa049310.68816654
120Thyroid hormone synthesis_Homo sapiens_hsa049180.68776727
121N-Glycan biosynthesis_Homo sapiens_hsa005100.68761405
122Proteasome_Homo sapiens_hsa030500.68576343
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68558723
124Endocytosis_Homo sapiens_hsa041440.68096511
125Alzheimers disease_Homo sapiens_hsa050100.67791780
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66753280
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.63840040
128Fatty acid degradation_Homo sapiens_hsa000710.61897474
129Metabolic pathways_Homo sapiens_hsa011000.61600373
1302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60912636
131ABC transporters_Homo sapiens_hsa020100.59635575
132Intestinal immune network for IgA production_Homo sapiens_hsa046720.59526626
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59449646
134Choline metabolism in cancer_Homo sapiens_hsa052310.59149311
135Bile secretion_Homo sapiens_hsa049760.58412243
136Rap1 signaling pathway_Homo sapiens_hsa040150.57672537
137Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57562360
138Proteoglycans in cancer_Homo sapiens_hsa052050.57533610
139Focal adhesion_Homo sapiens_hsa045100.56847257
140Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55954858
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54569003
142Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54494627
143Cardiac muscle contraction_Homo sapiens_hsa042600.53559942
144MAPK signaling pathway_Homo sapiens_hsa040100.52942924
145Dorso-ventral axis formation_Homo sapiens_hsa043200.52224748
146Arachidonic acid metabolism_Homo sapiens_hsa005900.52217685
147Histidine metabolism_Homo sapiens_hsa003400.51964273
148Ras signaling pathway_Homo sapiens_hsa040140.50618334
149SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49193700
150Pancreatic secretion_Homo sapiens_hsa049720.48876210
151Adherens junction_Homo sapiens_hsa045200.48672038
152Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47714606
153AMPK signaling pathway_Homo sapiens_hsa041520.47634668
154Pyrimidine metabolism_Homo sapiens_hsa002400.47415109
155Basal cell carcinoma_Homo sapiens_hsa052170.47081275
156Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46791514
157Central carbon metabolism in cancer_Homo sapiens_hsa052300.46013353
158Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44481089
159Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43921958
160Non-small cell lung cancer_Homo sapiens_hsa052230.43818451
161Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43476703
162Circadian rhythm_Homo sapiens_hsa047100.43182043
163Lysosome_Homo sapiens_hsa041420.43103249
164Fat digestion and absorption_Homo sapiens_hsa049750.41829068
165Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41666141
166Sphingolipid signaling pathway_Homo sapiens_hsa040710.41200279
167Lysine degradation_Homo sapiens_hsa003100.39483937
168Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38221844
169Nucleotide excision repair_Homo sapiens_hsa034200.37232209
170Glycerophospholipid metabolism_Homo sapiens_hsa005640.34546651
171Systemic lupus erythematosus_Homo sapiens_hsa053220.34088609

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