PCDHGA10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to cilium (GO:0061512)7.36781002
2negative regulation of T-helper cell differentiation (GO:0045623)5.84286871
3negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)5.84286871
4histamine secretion (GO:0001821)5.34436445
5negative regulation of thymocyte apoptotic process (GO:0070244)5.26295461
6regulation of memory T cell differentiation (GO:0043380)5.14151020
7histone H2A monoubiquitination (GO:0035518)5.05536588
8negative regulation of alpha-beta T cell differentiation (GO:0046639)4.80143232
9locomotory exploration behavior (GO:0035641)4.75559422
10positive regulation of alpha-beta T cell proliferation (GO:0046641)4.62374815
11regulation of T-helper 1 cell differentiation (GO:0045625)4.56823090
12negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.54842903
13behavioral response to nicotine (GO:0035095)4.54114331
14DNA double-strand break processing (GO:0000729)4.53226482
15positive regulation of T cell cytokine production (GO:0002726)4.51793479
16histamine transport (GO:0051608)4.50717590
17magnesium ion transport (GO:0015693)4.50642416
18regulation of penile erection (GO:0060405)4.36552924
19regulation of short-term neuronal synaptic plasticity (GO:0048172)4.18149239
20cellular response to vitamin D (GO:0071305)4.15481619
21ubiquinone biosynthetic process (GO:0006744)4.08445977
22synaptic vesicle maturation (GO:0016188)4.05490947
23regulation of regulatory T cell differentiation (GO:0045589)4.05255898
24positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.01088120
25neural tube formation (GO:0001841)4.00919319
26phosphatidylethanolamine biosynthetic process (GO:0006646)3.93304294
27positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.92752265
28histone H2A ubiquitination (GO:0033522)3.89876421
29parturition (GO:0007567)3.89591391
30cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.86866873
31positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.81793912
32regulation of germinal center formation (GO:0002634)3.80462856
33ubiquinone metabolic process (GO:0006743)3.78898069
34vocalization behavior (GO:0071625)3.75909881
35sodium ion export (GO:0071436)3.75056404
36layer formation in cerebral cortex (GO:0021819)3.73867188
37phosphatidylethanolamine metabolic process (GO:0046337)3.66992742
38parental behavior (GO:0060746)3.66015659
39synaptic vesicle docking involved in exocytosis (GO:0016081)3.63782841
40cell communication by electrical coupling (GO:0010644)3.63766322
41DNA deamination (GO:0045006)3.59334527
42organ formation (GO:0048645)3.58491118
43cellular potassium ion homeostasis (GO:0030007)3.56566305
44regulation of B cell apoptotic process (GO:0002902)3.52255684
45regulation of thymocyte apoptotic process (GO:0070243)3.51635303
46synaptic vesicle exocytosis (GO:0016079)3.51557790
47exploration behavior (GO:0035640)3.51019843
48regulation of synapse structural plasticity (GO:0051823)3.49892163
49dendrite morphogenesis (GO:0048813)3.48571562
50regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.44865053
51protein localization to Golgi apparatus (GO:0034067)3.44177993
52membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.42503293
53regulation of T-helper 2 cell differentiation (GO:0045628)3.34734475
54regulation of immunoglobulin secretion (GO:0051023)3.33752000
55protein complex biogenesis (GO:0070271)3.28783155
56regulation of glutamate receptor signaling pathway (GO:1900449)3.28095723
57regulation of alpha-beta T cell proliferation (GO:0046640)3.26418293
58epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.25925584
59establishment of nucleus localization (GO:0040023)3.24437753
60glutamate secretion (GO:0014047)3.23142101
61postsynaptic membrane organization (GO:0001941)3.21609540
62quinone biosynthetic process (GO:1901663)3.21356132
63kidney morphogenesis (GO:0060993)3.21259253
64embryonic epithelial tube formation (GO:0001838)3.20854252
65detection of temperature stimulus involved in sensory perception (GO:0050961)3.15711937
66detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.15711937
67regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.14508706
68regulation of neurotransmitter uptake (GO:0051580)3.13785736
69protein localization to synapse (GO:0035418)3.08882369
70dendritic spine morphogenesis (GO:0060997)3.07915771
71negative regulation of alpha-beta T cell activation (GO:0046636)3.07750082
72regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.06142830
73RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.04446086
74somite development (GO:0061053)3.02680061
75iron coordination entity transport (GO:1901678)3.02267564
76cranial nerve morphogenesis (GO:0021602)3.01837721
77epithelial tube formation (GO:0072175)3.01336904
78ionotropic glutamate receptor signaling pathway (GO:0035235)2.99433583
79regulation of apoptotic process involved in morphogenesis (GO:1902337)2.98826050
80negative regulation of cytosolic calcium ion concentration (GO:0051481)2.98253265
81regulation of synaptic vesicle exocytosis (GO:2000300)2.94543775
82cerebellar Purkinje cell differentiation (GO:0021702)2.94297469
83regulation of long-term neuronal synaptic plasticity (GO:0048169)2.93546415
84activation of protein kinase A activity (GO:0034199)2.93460447
85innervation (GO:0060384)2.92753626
86negative regulation of keratinocyte proliferation (GO:0010839)2.91734517
87regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.91396308
88positive regulation of synapse maturation (GO:0090129)2.89734297
89positive regulation of defense response to virus by host (GO:0002230)2.88811619
90regulation of T cell cytokine production (GO:0002724)2.88001914
91negative regulation of interleukin-17 production (GO:0032700)2.86030421
92potassium ion import (GO:0010107)2.85687830
93cell communication involved in cardiac conduction (GO:0086065)2.85405420
94glutamate receptor signaling pathway (GO:0007215)2.84601425
95inositol phosphate catabolic process (GO:0071545)2.83761518
96positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.83734211
97axonal fasciculation (GO:0007413)2.83173665
98phosphorylated carbohydrate dephosphorylation (GO:0046838)2.82241675
99inositol phosphate dephosphorylation (GO:0046855)2.82241675
100water-soluble vitamin biosynthetic process (GO:0042364)2.81898549
101regulation of neuronal synaptic plasticity (GO:0048168)2.80766821
102mitochondrial respiratory chain complex assembly (GO:0033108)2.80334183
103cerebellar granule cell differentiation (GO:0021707)2.80114658
104sulfation (GO:0051923)2.79610151
105thyroid gland development (GO:0030878)2.78158667
106positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.77248375
107neuromuscular process controlling balance (GO:0050885)2.76908455
108neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.76822637
109cytoskeletal anchoring at plasma membrane (GO:0007016)2.76800433
110protein localization to microtubule cytoskeleton (GO:0072698)2.76270725
111azole transport (GO:0045117)2.75922220
112positive regulation of T cell differentiation in thymus (GO:0033089)2.75775177
113cellular response to vitamin (GO:0071295)2.75146230
114proline transport (GO:0015824)2.74534868
115interferon-gamma secretion (GO:0072643)2.73127223
116detection of mechanical stimulus involved in sensory perception (GO:0050974)2.72929373
117synaptic transmission, glutamatergic (GO:0035249)2.72830611
118neurotransmitter secretion (GO:0007269)2.72414955
119negative regulation of transcription regulatory region DNA binding (GO:2000678)2.72093573
120negative regulation of telomere maintenance (GO:0032205)2.71574820
121regulation of mesoderm development (GO:2000380)2.70113636
122detection of temperature stimulus (GO:0016048)2.68369710
123long-term memory (GO:0007616)2.67547732
124indolalkylamine metabolic process (GO:0006586)2.67475521
125neuron cell-cell adhesion (GO:0007158)2.67420834
126vesicle fusion (GO:0006906)2.64991651
127cellular response to exogenous dsRNA (GO:0071360)2.64975702
128gamma-aminobutyric acid transport (GO:0015812)2.64676090
129neuron recognition (GO:0008038)2.64665955
130positive regulation of mast cell activation involved in immune response (GO:0033008)2.64281590
131positive regulation of mast cell degranulation (GO:0043306)2.64281590
132cellular sodium ion homeostasis (GO:0006883)2.64045356
133regulation of mitochondrial translation (GO:0070129)2.62854948
134regulation of dendritic spine morphogenesis (GO:0061001)2.62593356
135replication fork processing (GO:0031297)2.61807932
136potassium ion homeostasis (GO:0055075)2.61792798
137regulation of excitatory postsynaptic membrane potential (GO:0060079)2.61402920
138regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.59901580
139regulation of ARF protein signal transduction (GO:0032012)2.59762953
140G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.58925429
141prepulse inhibition (GO:0060134)2.58841380
142regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.58508921
143positive regulation of calcium-mediated signaling (GO:0050850)2.58004277
144plasma membrane repair (GO:0001778)2.57253043
145membrane depolarization during action potential (GO:0086010)2.55725212
146regulation of membrane repolarization (GO:0060306)2.55181470
147positive regulation of potassium ion transmembrane transport (GO:1901381)2.54581548
148negative regulation of T cell differentiation (GO:0045581)2.54388399
149regulation of postsynaptic membrane potential (GO:0060078)2.54350718
150regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.54203219
151neurotransmitter-gated ion channel clustering (GO:0072578)2.54108620
152ketone biosynthetic process (GO:0042181)2.52425382
153negative regulation of astrocyte differentiation (GO:0048712)2.52015782
154negative regulation of cell cycle arrest (GO:0071157)2.51188694
155adenosine metabolic process (GO:0046085)2.50753088
156neuron-neuron synaptic transmission (GO:0007270)2.50442133
157cell proliferation in forebrain (GO:0021846)2.49862363
158synaptic vesicle endocytosis (GO:0048488)2.48998297
159cell migration in hindbrain (GO:0021535)2.47928769
160prostate gland growth (GO:0060736)2.47663982
161membrane repolarization (GO:0086009)2.47367605
162regulation of synaptic vesicle transport (GO:1902803)2.47310882
163regulation of voltage-gated calcium channel activity (GO:1901385)2.46684488
164lateral sprouting from an epithelium (GO:0060601)2.46368393
1652-oxoglutarate metabolic process (GO:0006103)2.46184320
166positive regulation of glomerulus development (GO:0090193)2.45811901
167central nervous system projection neuron axonogenesis (GO:0021952)2.45780461
168determination of adult lifespan (GO:0008340)2.45754378
169aggressive behavior (GO:0002118)2.45678828
170positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.45439912
171nucleus localization (GO:0051647)2.44574668
172membrane hyperpolarization (GO:0060081)2.44167677
173positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.43728830
174regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.43188999
175auditory behavior (GO:0031223)2.42946409
176nerve growth factor signaling pathway (GO:0038180)2.42829944
177* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.42613036
178negative regulation of catenin import into nucleus (GO:0035414)2.41188704
179response to auditory stimulus (GO:0010996)2.40979036
180insulin-like growth factor receptor signaling pathway (GO:0048009)2.37911571
181positive regulation of membrane potential (GO:0045838)2.36906116
182neuronal ion channel clustering (GO:0045161)2.36421540
183membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.34918069
184regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.34834454
185regulation of axon extension involved in axon guidance (GO:0048841)2.34518632
186synapse organization (GO:0050808)2.33817276
187cardiac myofibril assembly (GO:0055003)2.33594215
188regulation of synaptic transmission, glutamatergic (GO:0051966)2.31660179
189regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.31042587
190cerebellar Purkinje cell layer development (GO:0021680)2.30959819
191suckling behavior (GO:0001967)2.29473009
192protein targeting to plasma membrane (GO:0072661)2.29467349
193regulation of synaptic plasticity (GO:0048167)2.27305226
194regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.27163547
195vesicle transport along microtubule (GO:0047496)2.25988953
196synapse assembly (GO:0007416)2.25947264
197L-amino acid import (GO:0043092)2.25444521

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.70449284
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.42498647
3ZFP57_27257070_Chip-Seq_ESCs_Mouse2.95240788
4GBX2_23144817_ChIP-Seq_PC3_Human2.79829017
5CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.67641644
6DROSHA_22980978_ChIP-Seq_HELA_Human2.64932141
7* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.63908816
8IGF1R_20145208_ChIP-Seq_DFB_Human2.59839961
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.58332915
10* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.56738312
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.44392200
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.43961134
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.43961134
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43617468
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42682932
16VDR_22108803_ChIP-Seq_LS180_Human2.42339392
17* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25353184
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.21438725
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.20746443
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.18163130
21* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.17644931
22* EED_16625203_ChIP-ChIP_MESCs_Mouse2.11523064
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09461608
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.08366648
25* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06259005
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.01967528
27EWS_26573619_Chip-Seq_HEK293_Human2.01730209
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00395311
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.99438722
30AR_21572438_ChIP-Seq_LNCaP_Human1.97670337
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.95741755
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.91173880
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.90180953
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85894118
35TAF15_26573619_Chip-Seq_HEK293_Human1.85576918
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.82133316
37FUS_26573619_Chip-Seq_HEK293_Human1.81860236
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76356619
39RNF2_27304074_Chip-Seq_NSC_Mouse1.75212092
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.71588019
41IRF1_19129219_ChIP-ChIP_H3396_Human1.69859162
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66964321
43REST_21632747_ChIP-Seq_MESCs_Mouse1.66522511
44ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.64579299
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63619693
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.61506145
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.59454894
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.59417213
49MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.56786714
50ER_23166858_ChIP-Seq_MCF-7_Human1.56335935
51* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.55626895
52WT1_25993318_ChIP-Seq_PODOCYTE_Human1.53694521
53TRIM28_21343339_ChIP-Seq_HEK293_Human1.53188438
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53117356
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.52031239
56MYC_18940864_ChIP-ChIP_HL60_Human1.50973301
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48981412
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48043055
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47690587
60SMAD4_21799915_ChIP-Seq_A2780_Human1.47285599
61EP300_21415370_ChIP-Seq_HL-1_Mouse1.46219889
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44833542
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42692989
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.39678619
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39496249
66KDM2B_26808549_Chip-Seq_K562_Human1.39415856
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38424640
68AHR_22903824_ChIP-Seq_MCF-7_Human1.38346894
69AR_19668381_ChIP-Seq_PC3_Human1.38277319
70* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38233614
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37967112
72TP53_16413492_ChIP-PET_HCT116_Human1.37859354
73TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37788717
74* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36676726
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36419190
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36229306
77DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.35865162
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33708790
79SOX2_21211035_ChIP-Seq_LN229_Gbm1.32696239
80CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32591510
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.30188973
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.29777782
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29054070
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28396474
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28396474
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28002784
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27244317
88* RING1B_27294783_Chip-Seq_ESCs_Mouse1.27201501
89* REST_18959480_ChIP-ChIP_MESCs_Mouse1.26523439
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25597676
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21433843
92SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21154174
93NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20978968
94ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20878989
95CBP_20019798_ChIP-Seq_JUKART_Human1.19421361
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19421361
97STAT3_23295773_ChIP-Seq_U87_Human1.19399988
98YAP1_20516196_ChIP-Seq_MESCs_Mouse1.19312916
99ZNF274_21170338_ChIP-Seq_K562_Hela1.19101844
100ERG_21242973_ChIP-ChIP_JURKAT_Human1.17732120
101SMAD3_21741376_ChIP-Seq_EPCs_Human1.17546390
102AUTS2_25519132_ChIP-Seq_293T-REX_Human1.16924285
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15781789
104RUNX2_22187159_ChIP-Seq_PCA_Human1.15687476
105CTNNB1_20460455_ChIP-Seq_HCT116_Human1.15667924
106ISL1_27105846_Chip-Seq_CPCs_Mouse1.14765277
107RING1B_27294783_Chip-Seq_NPCs_Mouse1.14427296
108SMAD3_21741376_ChIP-Seq_HESCs_Human1.13810528
109TCF4_22108803_ChIP-Seq_LS180_Human1.11906219
110NFE2_27457419_Chip-Seq_LIVER_Mouse1.11718140
111NCOR_22424771_ChIP-Seq_293T_Human1.10694995
112RXR_22108803_ChIP-Seq_LS180_Human1.10464705
113ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08316271
114PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08256145
115SMAD4_21741376_ChIP-Seq_EPCs_Human1.07682027
116SMAD4_21741376_ChIP-Seq_HESCs_Human1.07168890
117NANOG_19829295_ChIP-Seq_ESCs_Human1.06762494
118SOX2_19829295_ChIP-Seq_ESCs_Human1.06762494
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06590491
120JUN_21703547_ChIP-Seq_K562_Human1.06456822
121NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05655999
122EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05544095
123EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05261297
124FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05013740
125FOXA1_25329375_ChIP-Seq_VCAP_Human1.05013740
126OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03667179
127TP63_17297297_ChIP-ChIP_HaCaT_Human1.03112804
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02662191
129CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02416896
130KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01820728
131EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01096332
132KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00746629
133TCF4_23295773_ChIP-Seq_U87_Human1.00663119
134AR_25329375_ChIP-Seq_VCAP_Human0.99910308
135NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99505338
136SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99247703
137TP53_18474530_ChIP-ChIP_U2OS_Human0.98707028
138BCAT_22108803_ChIP-Seq_LS180_Human0.98689160
139BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97455951
140SMAD3_21741376_ChIP-Seq_ESCs_Human0.96821733
141HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96436550
142ESR1_20079471_ChIP-ChIP_T-47D_Human0.95211608
143TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94420159
144NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94176129
145TCF4_18268006_ChIP-ChIP_LS174T_Human0.93711315
146MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93521766
147P300_19829295_ChIP-Seq_ESCs_Human0.93122824
148SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92768758
149P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92626756
150* TP53_20018659_ChIP-ChIP_R1E_Mouse0.91929970
151TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91522094

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.01758951
2MP0000678_abnormal_parathyroid_gland4.12062903
3MP0006292_abnormal_olfactory_placode3.48266254
4MP0005646_abnormal_pituitary_gland3.17322914
5MP0003635_abnormal_synaptic_transmissio2.96072695
6MP0004270_analgesia2.77935682
7MP0009780_abnormal_chondrocyte_physiolo2.63379444
8MP0002132_abnormal_respiratory_system2.55524586
9MP0009697_abnormal_copulation2.52097053
10MP0003011_delayed_dark_adaptation2.40695924
11MP0002063_abnormal_learning/memory/cond2.25225594
12MP0002160_abnormal_reproductive_system2.24218523
13MP0000427_abnormal_hair_cycle2.22158339
14MP0002282_abnormal_trachea_morphology2.19417264
15MP0009046_muscle_twitch2.13274032
16MP0000751_myopathy2.07894592
17MP0000569_abnormal_digit_pigmentation2.07317096
18MP0001486_abnormal_startle_reflex2.03557859
19MP0005623_abnormal_meninges_morphology2.01542851
20MP0005084_abnormal_gallbladder_morpholo1.98728279
21MP0009745_abnormal_behavioral_response1.97071143
22MP0002064_seizures1.94787998
23MP0003646_muscle_fatigue1.93433750
24MP0001727_abnormal_embryo_implantation1.92701927
25MP0003880_abnormal_central_pattern1.92464260
26MP0000631_abnormal_neuroendocrine_gland1.91817204
27MP0003045_fibrosis1.89929811
28MP0002102_abnormal_ear_morphology1.82864702
29MP0004272_abnormal_basement_membrane1.82645250
30MP0002572_abnormal_emotion/affect_behav1.79918254
31MP0008877_abnormal_DNA_methylation1.79452598
32MP0004233_abnormal_muscle_weight1.79061604
33MP0005423_abnormal_somatic_nervous1.77143192
34MP0005389_reproductive_system_phenotype1.77136742
35MP0005503_abnormal_tendon_morphology1.77020631
36MP0004858_abnormal_nervous_system1.76125986
37MP0001299_abnormal_eye_distance/1.75015423
38MP0004215_abnormal_myocardial_fiber1.69897332
39MP0008438_abnormal_cutaneous_collagen1.67925152
40MP0002734_abnormal_mechanical_nocicepti1.66793015
41MP0002876_abnormal_thyroid_physiology1.66354062
42MP0003300_gastrointestinal_ulcer1.65859419
43MP0003787_abnormal_imprinting1.65814059
44MP0002249_abnormal_larynx_morphology1.61818088
45MP0002909_abnormal_adrenal_gland1.61016567
46MP0003705_abnormal_hypodermis_morpholog1.59474680
47MP0000778_abnormal_nervous_system1.57011667
48MP0004133_heterotaxia1.55166454
49MP0003283_abnormal_digestive_organ1.53583569
50MP0001968_abnormal_touch/_nociception1.51963120
51MP0002127_abnormal_cardiovascular_syste1.51931000
52MP0004084_abnormal_cardiac_muscle1.51505233
53MP0008569_lethality_at_weaning1.50803969
54MP0004147_increased_porphyrin_level1.47922599
55MP0003122_maternal_imprinting1.46556325
56MP0005187_abnormal_penis_morphology1.44306142
57MP0002822_catalepsy1.43974423
58MP0002272_abnormal_nervous_system1.43722898
59MP0004885_abnormal_endolymph1.43526512
60MP0008872_abnormal_physiological_respon1.41436966
61MP0002234_abnormal_pharynx_morphology1.41389390
62MP0005551_abnormal_eye_electrophysiolog1.38909136
63MP0002751_abnormal_autonomic_nervous1.37421887
64MP0004811_abnormal_neuron_physiology1.36980760
65MP0002184_abnormal_innervation1.36499400
66MP0003252_abnormal_bile_duct1.35462359
67MP0000049_abnormal_middle_ear1.33513949
68MP0002090_abnormal_vision1.32228127
69MP0010368_abnormal_lymphatic_system1.31504432
70MP0004145_abnormal_muscle_electrophysio1.27622873
71MP0004019_abnormal_vitamin_homeostasis1.27264310
72MP0010329_abnormal_lipoprotein_level1.27227280
73MP0003195_calcinosis1.26544052
74MP0000681_abnormal_thyroid_gland1.26466083
75MP0002067_abnormal_sensory_capabilities1.23934463
76MP0000955_abnormal_spinal_cord1.23744271
77MP0009250_abnormal_appendicular_skeleto1.23199699
78MP0000534_abnormal_ureter_morphology1.23194607
79MP0003137_abnormal_impulse_conducting1.22107215
80MP0004085_abnormal_heartbeat1.21444850
81MP0002557_abnormal_social/conspecific_i1.21109886
82MP0002882_abnormal_neuron_morphology1.20722398
83MP0001958_emphysema1.20260490
84MP0001905_abnormal_dopamine_level1.19304573
85MP0001440_abnormal_grooming_behavior1.19133811
86MP0000013_abnormal_adipose_tissue1.18757562
87MP0001177_atelectasis1.17569792
88MP0003279_aneurysm1.17287075
89MP0002837_dystrophic_cardiac_calcinosis1.14805426
90MP0002108_abnormal_muscle_morphology1.10749603
91MP0001293_anophthalmia1.10733140
92MP0008995_early_reproductive_senescence1.10453113
93MP0005386_behavior/neurological_phenoty1.09266839
94MP0004924_abnormal_behavior1.09266839
95MP0001502_abnormal_circadian_rhythm1.04319970
96MP0001501_abnormal_sleep_pattern1.03916925
97MP0003385_abnormal_body_wall1.03532811
98MP0004087_abnormal_muscle_fiber1.03456513
99MP0000230_abnormal_systemic_arterial1.02839826
100MP0008775_abnormal_heart_ventricle1.02213949
101MP0006276_abnormal_autonomic_nervous1.02052880
102MP0002928_abnormal_bile_duct1.01543434
103MP0002152_abnormal_brain_morphology1.01537688
104MP0003633_abnormal_nervous_system1.01287791
105MP0005645_abnormal_hypothalamus_physiol1.00879547
106MP0002733_abnormal_thermal_nociception1.00143801
107MP0005253_abnormal_eye_physiology1.00028456
108MP0001970_abnormal_pain_threshold0.99683048
109MP0000372_irregular_coat_pigmentation0.97506001
110MP0003634_abnormal_glial_cell0.96660532
111MP0009053_abnormal_anal_canal0.96623186
112MP0003121_genomic_imprinting0.96454624
113MP0004036_abnormal_muscle_relaxation0.95952205
114MP0003119_abnormal_digestive_system0.95340589
115MP0004142_abnormal_muscle_tone0.94431620
116MP0004130_abnormal_muscle_cell0.93656638
117MP0001485_abnormal_pinna_reflex0.93515008
118MP0005275_abnormal_skin_tensile0.93454962
119MP0002066_abnormal_motor_capabilities/c0.93216385
120MP0008961_abnormal_basal_metabolism0.93086228
121MP0006035_abnormal_mitochondrial_morpho0.91828232
122MP0002089_abnormal_postnatal_growth/wei0.91565986
123MP0000733_abnormal_muscle_development0.91514838
124MP0002736_abnormal_nociception_after0.91319484
125MP0003329_amyloid_beta_deposits0.91295384
126MP0001986_abnormal_taste_sensitivity0.89189882
127MP0004484_altered_response_of0.88186048
128MP0003937_abnormal_limbs/digits/tail_de0.87940247
129MP0005620_abnormal_muscle_contractility0.87456751
130MP0009384_cardiac_valve_regurgitation0.87258964
131MP0001984_abnormal_olfaction0.87166320
132MP0001270_distended_abdomen0.86922286
133MP0000003_abnormal_adipose_tissue0.86795892
134MP0000428_abnormal_craniofacial_morphol0.86741217
135MP0000383_abnormal_hair_follicle0.85019396
136MP0006072_abnormal_retinal_apoptosis0.84989265
137MP0003631_nervous_system_phenotype0.84966925
138MP0003115_abnormal_respiratory_system0.84399961
139MP0003938_abnormal_ear_development0.84195975
140MP0002295_abnormal_pulmonary_circulatio0.83995488
141MP0002896_abnormal_bone_mineralization0.83747594
142MP0002972_abnormal_cardiac_muscle0.83658930
143MP0003638_abnormal_response/metabolism_0.82513720
144MP0006138_congestive_heart_failure0.82487067
145MP0001765_abnormal_ion_homeostasis0.82228241
146MP0005248_abnormal_Harderian_gland0.81314750
147MP0003935_abnormal_craniofacial_develop0.81025782
148MP0002752_abnormal_somatic_nervous0.80513324
149MP0005076_abnormal_cell_differentiation0.79475008
150MP0002168_other_aberrant_phenotype0.79423720
151MP0003942_abnormal_urinary_system0.79287432
152MP0005257_abnormal_intraocular_pressure0.78296816
153MP0003091_abnormal_cell_migration0.77038622
154MP0005167_abnormal_blood-brain_barrier0.76608524
155MP0003632_abnormal_nervous_system0.75528597
156MP0002735_abnormal_chemical_nociception0.75196887
157MP0001919_abnormal_reproductive_system0.74902511
158MP0002277_abnormal_respiratory_mucosa0.74621770
159MP0002638_abnormal_pupillary_reflex0.73722816
160MP0000026_abnormal_inner_ear0.71592731
161MP0005195_abnormal_posterior_eye0.69912324
162MP0000613_abnormal_salivary_gland0.69154268

Predicted human phenotypes

RankGene SetZ-score
1Progressive inability to walk (HP:0002505)5.12590769
2Symptomatic seizures (HP:0011145)4.40481953
3Pancreatic cysts (HP:0001737)4.01037060
4Pancreatic fibrosis (HP:0100732)3.94058699
5Mesangial abnormality (HP:0001966)3.81239104
6Abnormality of the costochondral junction (HP:0000919)3.71229594
7Shallow orbits (HP:0000586)3.48610352
8Focal motor seizures (HP:0011153)3.39761058
9Action tremor (HP:0002345)3.36757638
10Broad metatarsal (HP:0001783)3.33577846
11Thyroiditis (HP:0100646)3.31460066
12Inability to walk (HP:0002540)3.29224701
13True hermaphroditism (HP:0010459)3.23764888
14Focal seizures (HP:0007359)3.14502560
15Myokymia (HP:0002411)3.11418653
16Premature loss of primary teeth (HP:0006323)3.11398031
17Abnormality of the renal cortex (HP:0011035)3.02121426
18Congenital, generalized hypertrichosis (HP:0004540)3.01279839
19Nephronophthisis (HP:0000090)3.00599652
20Abnormality of B cell number (HP:0010975)2.98750619
21Delayed epiphyseal ossification (HP:0002663)2.97211815
22Genetic anticipation (HP:0003743)2.96838843
23Pendular nystagmus (HP:0012043)2.90566530
24Abnormality of the proximal phalanges of the hand (HP:0009834)2.88898284
25Abnormality of the renal medulla (HP:0100957)2.86930811
26Progressive cerebellar ataxia (HP:0002073)2.86822334
27Protrusio acetabuli (HP:0003179)2.85773986
28Asplenia (HP:0001746)2.85760330
29Abnormality of midbrain morphology (HP:0002418)2.84583505
30Molar tooth sign on MRI (HP:0002419)2.84583505
31B lymphocytopenia (HP:0010976)2.81803248
32Autoimmune thrombocytopenia (HP:0001973)2.80910204
33Bone cyst (HP:0012062)2.79288323
34Aplasia/Hypoplasia of the spleen (HP:0010451)2.78950088
35Azoospermia (HP:0000027)2.77673615
36Epileptic encephalopathy (HP:0200134)2.77614011
37Long nose (HP:0003189)2.75927690
38Severe combined immunodeficiency (HP:0004430)2.74969679
39Polydipsia (HP:0001959)2.73876998
40Abnormal drinking behavior (HP:0030082)2.73876998
41Visual hallucinations (HP:0002367)2.73856263
42Keratoconus (HP:0000563)2.70979514
43Increased corneal curvature (HP:0100692)2.70979514
44Enlarged epiphyses (HP:0010580)2.70512801
45Small hand (HP:0200055)2.68706190
46Facial diplegia (HP:0001349)2.68559692
47Abolished electroretinogram (ERG) (HP:0000550)2.67872778
48Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.67325094
49Short 4th metacarpal (HP:0010044)2.67325094
50Macroorchidism (HP:0000053)2.65271310
51Cystic liver disease (HP:0006706)2.63864147
52Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.62296108
53Decreased activity of mitochondrial respiratory chain (HP:0008972)2.61617104
54Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.61617104
55Abnormal biliary tract physiology (HP:0012439)2.61229608
56Bile duct proliferation (HP:0001408)2.61229608
57Chorioretinal atrophy (HP:0000533)2.46593633
58Chronic otitis media (HP:0000389)2.45676474
59Cerebral aneurysm (HP:0004944)2.42530098
60Abnormality of the middle phalanges of the toes (HP:0010183)2.36956624
61Prolonged QT interval (HP:0001657)2.35663791
62Hemiplegia (HP:0002301)2.34827819
63Megalencephaly (HP:0001355)2.32125032
64Hypoglycemic seizures (HP:0002173)2.31451569
65Supernumerary spleens (HP:0009799)2.29998957
66Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.29735962
67Abnormality of the right ventricle (HP:0001707)2.29326676
68Renal cortical cysts (HP:0000803)2.25601592
69Central scotoma (HP:0000603)2.25380809
70Morphological abnormality of the middle ear (HP:0008609)2.22187067
71Clumsiness (HP:0002312)2.21987977
72Dysmetric saccades (HP:0000641)2.21539225
73Dysdiadochokinesis (HP:0002075)2.19131532
74Neoplasm of the heart (HP:0100544)2.17646333
75Furrowed tongue (HP:0000221)2.17603702
76Symphalangism affecting the phalanges of the hand (HP:0009773)2.17440847
77Abnormality of the phalanges of the 5th finger (HP:0004213)2.16345563
78Tubular atrophy (HP:0000092)2.16239638
79Febrile seizures (HP:0002373)2.15343979
80Thin bony cortex (HP:0002753)2.13486930
81Short hallux (HP:0010109)2.12034268
82Aqueductal stenosis (HP:0002410)2.11093230
83Urinary bladder sphincter dysfunction (HP:0002839)2.10323413
84Broad-based gait (HP:0002136)2.09432217
85Abnormality of the renal collecting system (HP:0004742)2.09355746
86Sudden death (HP:0001699)2.08424046
87Narrow palate (HP:0000189)2.08205850
88Excessive salivation (HP:0003781)2.06846021
89Drooling (HP:0002307)2.06846021
90Aplasia/Hypoplasia of the hallux (HP:0008362)2.05459136
91Overgrowth (HP:0001548)2.04564666
92Aortic aneurysm (HP:0004942)2.02782348
93Atrial fibrillation (HP:0005110)2.01544332
94Abnormality of the 4th metacarpal (HP:0010012)2.00536737
95Sclerocornea (HP:0000647)2.00044875
96Supranuclear gaze palsy (HP:0000605)1.99381153
97Gaze-evoked nystagmus (HP:0000640)1.99178088
98Turricephaly (HP:0000262)1.98705905
99Aplasia involving bones of the extremities (HP:0009825)1.98421089
100Aplasia involving bones of the upper limbs (HP:0009823)1.98421089
101Aplasia of the phalanges of the hand (HP:0009802)1.98421089
102Bladder diverticulum (HP:0000015)1.98393110
103Abnormal social behavior (HP:0012433)1.98331321
104Impaired social interactions (HP:0000735)1.98331321
105Aplasia/Hypoplasia of the tibia (HP:0005772)1.97431952
106Depression (HP:0000716)1.97245622
107Widely patent fontanelles and sutures (HP:0004492)1.95920910
108Polyuria (HP:0000103)1.95684891
109Primary atrial arrhythmia (HP:0001692)1.95610461
110Postural instability (HP:0002172)1.94828979
111Hepatoblastoma (HP:0002884)1.94774751
112Truncal ataxia (HP:0002078)1.94643581
113Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.94328826
114Hyperglycinemia (HP:0002154)1.94178190
115Hypoventilation (HP:0002791)1.91870084
116Enlarged kidneys (HP:0000105)1.91218626
117Pointed chin (HP:0000307)1.89344180
118Progressive macrocephaly (HP:0004481)1.88099108
119Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.87901145
120Trigonocephaly (HP:0000243)1.87854645
121Poor eye contact (HP:0000817)1.87755008
122Abnormality of the prostate (HP:0008775)1.87701971
123Absence seizures (HP:0002121)1.87543441
124Combined immunodeficiency (HP:0005387)1.87366816
125Abnormal number of incisors (HP:0011064)1.87245374
126Arterial tortuosity (HP:0005116)1.86739671
127Buphthalmos (HP:0000557)1.86373501
128Congenital stationary night blindness (HP:0007642)1.86289916
129Chronic hepatic failure (HP:0100626)1.86139170
130Hypocalcemia (HP:0002901)1.85924345
131Short 1st metacarpal (HP:0010034)1.85918204
132Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.85918204
133Panhypogammaglobulinemia (HP:0003139)1.85587408
134Aneurysm (HP:0002617)1.85053232
135Midline defect of the nose (HP:0004122)1.84858789
136Bronchomalacia (HP:0002780)1.84059982
137Short tibia (HP:0005736)1.83546009
138Atonic seizures (HP:0010819)1.83294871
139Type II lissencephaly (HP:0007260)1.83060508
140Colon cancer (HP:0003003)1.82732630
141Decreased central vision (HP:0007663)1.82520733
142Ankle contracture (HP:0006466)1.82028205
1433-Methylglutaconic aciduria (HP:0003535)1.81891981
144Medial flaring of the eyebrow (HP:0010747)1.81890708
145Premature rupture of membranes (HP:0001788)1.81706796
146Vascular tortuosity (HP:0004948)1.81246304
147Scotoma (HP:0000575)1.80949177
148Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80886605
149Generalized tonic-clonic seizures (HP:0002069)1.80753221
150Supraventricular arrhythmia (HP:0005115)1.80008350
151Abnormal spermatogenesis (HP:0008669)1.79627716
152Acute necrotizing encephalopathy (HP:0006965)1.79006001
153Hyperacusis (HP:0010780)1.78660152
154Hemiparesis (HP:0001269)1.77944704
155Congenital hepatic fibrosis (HP:0002612)1.77214358
156Bowel diverticulosis (HP:0005222)1.76931804
157Aplasia/hypoplasia of the uterus (HP:0008684)1.76274681
158Supraventricular tachycardia (HP:0004755)1.76205689
159Abnormal EKG (HP:0003115)1.75774202
160Lower limb amyotrophy (HP:0007210)1.75368396
161Abnormality of renal excretion (HP:0011036)1.75336692
162Ankle clonus (HP:0011448)1.74627738
163Ventricular fibrillation (HP:0001663)1.74594591
164Mutism (HP:0002300)1.74422881
165Aplasia/Hypoplasia of the patella (HP:0006498)1.73819993
166Abnormality of the phalanges of the 2nd finger (HP:0009541)1.73639909
167Bundle branch block (HP:0011710)1.73473793
168IgG deficiency (HP:0004315)1.73465719
169Abnormality of the nasal septum (HP:0000419)1.73435151
170Elfin facies (HP:0004428)1.73334483
171Impaired smooth pursuit (HP:0007772)1.73165050
172Obsessive-compulsive behavior (HP:0000722)1.72250268
173Mesomelia (HP:0003027)1.72116392
174Methylmalonic acidemia (HP:0002912)1.71199582
175Lymphangioma (HP:0100764)1.70309914
176Eosinophilia (HP:0001880)1.69992717
177Dilatation of the ascending aorta (HP:0005111)1.69680834
178Exercise-induced myalgia (HP:0003738)1.68845053
179Syncope (HP:0001279)1.68519579
180Increased variability in muscle fiber diameter (HP:0003557)1.68474262
181Synostosis of carpal bones (HP:0005048)1.68027605
182Potter facies (HP:0002009)1.67618775
183Dysmetria (HP:0001310)1.66324060
184Upper limb amyotrophy (HP:0009129)1.65683530
185Distal upper limb amyotrophy (HP:0007149)1.65683530
186Torticollis (HP:0000473)1.65280348
187Mitral valve prolapse (HP:0001634)1.64146134
188Enlarged penis (HP:0000040)1.64004599
189Atrophic scars (HP:0001075)1.63534925
190Aortic dissection (HP:0002647)1.62880324
191Anteriorly placed anus (HP:0001545)1.62659209
192Narrow nasal bridge (HP:0000446)1.62273971
193Hypoplasia of the maxilla (HP:0000327)1.62038323
194Astrocytoma (HP:0009592)1.61513618
195Abnormality of the astrocytes (HP:0100707)1.61513618
196Dialeptic seizures (HP:0011146)1.61349910
197Stereotypic behavior (HP:0000733)1.61131720

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.36856246
2NTRK33.06660423
3MARK13.06084376
4EIF2AK32.99866060
5ADRBK22.80026628
6EPHA42.74435252
7PRKD32.60199576
8GRK12.58313734
9MAPKAPK32.51870154
10TLK12.51268306
11EIF2AK12.41041937
12WNK42.38523877
13NUAK12.36354587
14MAP3K92.27978843
15TAOK32.27148898
16PAK62.24918359
17RIPK12.19340161
18STK392.10517470
19PHKG12.10422328
20PHKG22.10422328
21MAP3K41.95067421
22NTRK21.94059078
23CAMK1G1.91391273
24OXSR11.86233560
25PINK11.86033055
26PDGFRA1.82671151
27WNK31.78323714
28MAP4K21.76696673
29MINK11.73852067
30TEC1.68846689
31BMPR1B1.66450042
32CAMKK11.64106771
33NTRK11.63794933
34VRK21.63764660
35DMPK1.60433220
36DDR21.57217008
37KSR21.57057255
38TRIB31.56634948
39DAPK21.54983074
40SIK11.54221546
41MAPKAPK51.51671082
42LMTK21.50619848
43TNIK1.49911358
44LATS21.48043852
45CAMK1D1.45243375
46FGFR21.42218918
47LATS11.38308087
48STK381.36974052
49CASK1.34177625
50KSR11.32750011
51SIK21.30508630
52PRKCH1.28310399
53PAK31.26252033
54EEF2K1.25398500
55CDC42BPA1.20481199
56TAOK11.19203707
57CDK51.18411000
58RET1.18358038
59INSRR1.17231118
60DYRK21.15904995
61TYRO31.15553951
62ITK1.14253305
63MARK21.13849907
64WNK11.09663232
65SGK31.07415856
66MAP3K71.03936822
67PKN21.03388190
68MKNK21.02667126
69EIF2AK21.00953992
70MAP3K20.99758114
71MAPK130.99289601
72PRPF4B0.97590487
73RPS6KA20.94850413
74ICK0.91297364
75SGK20.89668430
76MAP2K40.89383418
77PTK20.87758285
78AKT30.86829541
79PTK2B0.86775206
80ADRBK10.85451776
81CAMKK20.85367080
82STK110.85188066
83TRPM70.85075348
84VRK10.84781860
85CAMK40.84730493
86PDGFRB0.83913155
87BCKDK0.83859126
88CAMK10.83473802
89SYK0.83383954
90ACVR1B0.82021660
91BMX0.81489623
92TAF10.81282280
93TTN0.81221961
94CSNK1G20.80974907
95FGFR10.80869208
96EPHB20.80015069
97ALK0.78881354
98SGK2230.78836311
99SGK4940.78836311
100PRKD20.74120154
101SGK10.73105447
102FER0.71436448
103MAP2K70.70988810
104ZAK0.70494347
105PRKD10.68916038
106FLT30.67364703
107ROCK10.67064620
108CSNK1G30.66097740
109PRKCG0.65517213
110ERBB20.65255593
111MTOR0.65192854
112GRK70.64999086
113CAMK2A0.62013117
114PNCK0.61541362
115NEK10.60652942
116EPHA30.60326456
117RPS6KA30.58816749
118DAPK10.56967299
119UHMK10.56910574
120TXK0.56307107
121PLK20.54844846
122TRIM280.54451496
123CSNK1G10.54427061
124DYRK30.54285230
125GRK50.53766127
126NLK0.53248536
127PRKAA10.53236147
128FYN0.53198766
129PRKCE0.53092253
130MAPK100.52185967
131PRKCZ0.50592152
132CDK150.50206465
133IGF1R0.50003839
134CDK180.48093626
135IKBKB0.47980695
136CDK140.47685485
137ROCK20.47534010
138KIT0.45345952
139MATK0.45231172
140INSR0.44998580
141PAK20.44672080
142CAMK2D0.43814651
143SRC0.43676211
144PTK60.43271883
145GSK3A0.42556189
146CSNK1A1L0.41944413
147TIE10.41686755
148PRKACA0.41461091
149STK30.41386373
150ERBB30.41345307
151FGFR30.41242188
152BTK0.41037912
153DYRK1A0.40774272
154MAPK80.40676052
155PIK3CA0.40623245
156PRKCA0.40395576
157STK38L0.39688182
158MUSK0.39509805
159NME10.38943782
160BRSK20.38585071
161MAPK150.37367968
162TTK0.36921483
163IRAK10.36674330
164ABL10.36311961
165MAP2K20.35700721
166BCR0.35163663
167RPS6KB20.34791600
168FES0.33203692
169RPS6KA60.32190555
170PRKACG0.31750592
171LYN0.31036032
172MKNK10.30862100
173CSNK1A10.28513173

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.10497670
2Selenocompound metabolism_Homo sapiens_hsa004503.15070216
3Sulfur metabolism_Homo sapiens_hsa009202.69985875
4Nicotine addiction_Homo sapiens_hsa050332.32645407
5Circadian entrainment_Homo sapiens_hsa047132.16341251
6Ether lipid metabolism_Homo sapiens_hsa005652.11252479
7GABAergic synapse_Homo sapiens_hsa047272.05300312
8Linoleic acid metabolism_Homo sapiens_hsa005911.98348286
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.98063724
10Glutamatergic synapse_Homo sapiens_hsa047241.93916796
11Maturity onset diabetes of the young_Homo sapiens_hsa049501.93764756
12Olfactory transduction_Homo sapiens_hsa047401.89406955
13Long-term potentiation_Homo sapiens_hsa047201.88937703
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.88410968
15Insulin secretion_Homo sapiens_hsa049111.86020499
16Morphine addiction_Homo sapiens_hsa050321.86016327
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.85329872
18Synaptic vesicle cycle_Homo sapiens_hsa047211.83042082
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79915097
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78318844
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.76482183
22Salivary secretion_Homo sapiens_hsa049701.76343368
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.76166534
24Dilated cardiomyopathy_Homo sapiens_hsa054141.75959288
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.74773827
26Parkinsons disease_Homo sapiens_hsa050121.73180711
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.72508702
28Sulfur relay system_Homo sapiens_hsa041221.71258410
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.66603554
30Amphetamine addiction_Homo sapiens_hsa050311.66213142
31Oxidative phosphorylation_Homo sapiens_hsa001901.65571768
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.64698763
33Cholinergic synapse_Homo sapiens_hsa047251.63120079
34Renin secretion_Homo sapiens_hsa049241.60737950
35Homologous recombination_Homo sapiens_hsa034401.58818203
36Gastric acid secretion_Homo sapiens_hsa049711.58780969
37Dopaminergic synapse_Homo sapiens_hsa047281.55511761
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.53641076
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.52996017
40Oxytocin signaling pathway_Homo sapiens_hsa049211.48721204
41Butanoate metabolism_Homo sapiens_hsa006501.46835213
42Type II diabetes mellitus_Homo sapiens_hsa049301.46209833
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.46150580
44Glycerolipid metabolism_Homo sapiens_hsa005611.43377242
45Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.39916744
46Cocaine addiction_Homo sapiens_hsa050301.39143904
47Axon guidance_Homo sapiens_hsa043601.38755878
48RNA degradation_Homo sapiens_hsa030181.36549160
49Gap junction_Homo sapiens_hsa045401.34460469
50GnRH signaling pathway_Homo sapiens_hsa049121.33714853
51Glioma_Homo sapiens_hsa052141.32556465
52cAMP signaling pathway_Homo sapiens_hsa040241.32245532
53Calcium signaling pathway_Homo sapiens_hsa040201.28011985
54cGMP-PKG signaling pathway_Homo sapiens_hsa040221.26846564
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23750711
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23747481
57Primary immunodeficiency_Homo sapiens_hsa053401.23684355
58Long-term depression_Homo sapiens_hsa047301.21737670
59Phototransduction_Homo sapiens_hsa047441.20928671
60Estrogen signaling pathway_Homo sapiens_hsa049151.18410338
61Thyroid hormone signaling pathway_Homo sapiens_hsa049191.16706677
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.16189751
63RNA polymerase_Homo sapiens_hsa030201.11134983
64Chemical carcinogenesis_Homo sapiens_hsa052041.10890944
65Melanogenesis_Homo sapiens_hsa049161.08232976
66Taste transduction_Homo sapiens_hsa047421.07482976
67Fanconi anemia pathway_Homo sapiens_hsa034601.07294131
68Dorso-ventral axis formation_Homo sapiens_hsa043201.07161963
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04330432
70Serotonergic synapse_Homo sapiens_hsa047261.03568998
71Nitrogen metabolism_Homo sapiens_hsa009101.02939820
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02272826
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01725680
74SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01670771
75mTOR signaling pathway_Homo sapiens_hsa041501.00432565
76Focal adhesion_Homo sapiens_hsa045101.00229336
77Tryptophan metabolism_Homo sapiens_hsa003800.99980342
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.99195901
79ErbB signaling pathway_Homo sapiens_hsa040120.98761710
80ECM-receptor interaction_Homo sapiens_hsa045120.96241124
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.95465442
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95236579
83Protein export_Homo sapiens_hsa030600.92271925
84Retinol metabolism_Homo sapiens_hsa008300.91121156
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88661122
86Asthma_Homo sapiens_hsa053100.88515369
87Rap1 signaling pathway_Homo sapiens_hsa040150.87735806
88Proteoglycans in cancer_Homo sapiens_hsa052050.87388857
89Endometrial cancer_Homo sapiens_hsa052130.86925842
90Alzheimers disease_Homo sapiens_hsa050100.86066503
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86033671
92Proteasome_Homo sapiens_hsa030500.85656646
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83416952
94Adherens junction_Homo sapiens_hsa045200.82977879
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.82807178
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82732042
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81929588
98Thyroid hormone synthesis_Homo sapiens_hsa049180.81492242
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80940631
100Wnt signaling pathway_Homo sapiens_hsa043100.80883145
101Cardiac muscle contraction_Homo sapiens_hsa042600.80864384
102Hedgehog signaling pathway_Homo sapiens_hsa043400.80784431
103Mineral absorption_Homo sapiens_hsa049780.80270188
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.80117555
105Pyrimidine metabolism_Homo sapiens_hsa002400.79136128
106Renal cell carcinoma_Homo sapiens_hsa052110.78097698
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78043560
108MAPK signaling pathway_Homo sapiens_hsa040100.77434976
109Pancreatic secretion_Homo sapiens_hsa049720.77258330
110Basal cell carcinoma_Homo sapiens_hsa052170.76731590
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76641659
112Circadian rhythm_Homo sapiens_hsa047100.75419218
113Arachidonic acid metabolism_Homo sapiens_hsa005900.73443123
114Propanoate metabolism_Homo sapiens_hsa006400.72855929
115Hippo signaling pathway_Homo sapiens_hsa043900.72507972
116Glucagon signaling pathway_Homo sapiens_hsa049220.71980037
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71467115
118Choline metabolism in cancer_Homo sapiens_hsa052310.71168858
119Purine metabolism_Homo sapiens_hsa002300.70680851
120Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69862806
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69798778
122VEGF signaling pathway_Homo sapiens_hsa043700.69697444
123Fat digestion and absorption_Homo sapiens_hsa049750.68044378
124Amoebiasis_Homo sapiens_hsa051460.66433748
125Ras signaling pathway_Homo sapiens_hsa040140.66233591
126Colorectal cancer_Homo sapiens_hsa052100.65744177
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.65437008
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65418667
129Primary bile acid biosynthesis_Homo sapiens_hsa001200.64873954
130Insulin signaling pathway_Homo sapiens_hsa049100.64864459
131Caffeine metabolism_Homo sapiens_hsa002320.64766443
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.64210477
133Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64114022
134Non-small cell lung cancer_Homo sapiens_hsa052230.64062645
135Tight junction_Homo sapiens_hsa045300.63006413
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.62672127
137Insulin resistance_Homo sapiens_hsa049310.62143096
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61432692
139Melanoma_Homo sapiens_hsa052180.59303992
140Lysine degradation_Homo sapiens_hsa003100.58772478
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58610668
142Endocytosis_Homo sapiens_hsa041440.58610218
143Chronic myeloid leukemia_Homo sapiens_hsa052200.58370682
144Bile secretion_Homo sapiens_hsa049760.56833840
145Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56793859
146Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54671719
147AMPK signaling pathway_Homo sapiens_hsa041520.53987699
148Oocyte meiosis_Homo sapiens_hsa041140.53428429
149Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53301702
150Protein digestion and absorption_Homo sapiens_hsa049740.52835545
151Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52053781
152Platelet activation_Homo sapiens_hsa046110.51842933
153Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51797294
154Fatty acid biosynthesis_Homo sapiens_hsa000610.51452779
155Sphingolipid signaling pathway_Homo sapiens_hsa040710.50220420
156Ovarian steroidogenesis_Homo sapiens_hsa049130.47040630
157Peroxisome_Homo sapiens_hsa041460.46575521
158Steroid biosynthesis_Homo sapiens_hsa001000.44722652
159Huntingtons disease_Homo sapiens_hsa050160.43501977
160Metabolic pathways_Homo sapiens_hsa011000.41658396
161One carbon pool by folate_Homo sapiens_hsa006700.38556012
162Alcoholism_Homo sapiens_hsa050340.35291862
163Type I diabetes mellitus_Homo sapiens_hsa049400.35029180
164Fatty acid elongation_Homo sapiens_hsa000620.33000266
165Starch and sucrose metabolism_Homo sapiens_hsa005000.31959184
166Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30986931

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