PCDHGA11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.81340023
2locomotory exploration behavior (GO:0035641)5.73799562
3synaptic vesicle maturation (GO:0016188)5.64519871
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.43331933
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.28868378
6vocalization behavior (GO:0071625)5.17018153
7layer formation in cerebral cortex (GO:0021819)5.00247647
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.00049222
9synaptic vesicle exocytosis (GO:0016079)4.92911244
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.89031122
11glutamate secretion (GO:0014047)4.73276646
12protein localization to synapse (GO:0035418)4.67082615
13regulation of synaptic vesicle exocytosis (GO:2000300)4.62709176
14regulation of synapse structural plasticity (GO:0051823)4.60332276
15regulation of glutamate receptor signaling pathway (GO:1900449)4.51734820
16chondrocyte proliferation (GO:0035988)4.46228960
17exploration behavior (GO:0035640)4.43817540
18positive regulation of synapse maturation (GO:0090129)4.39653527
19neurotransmitter-gated ion channel clustering (GO:0072578)4.39409402
20endodermal cell differentiation (GO:0035987)4.37328371
21cellular potassium ion homeostasis (GO:0030007)4.32865812
22neuron cell-cell adhesion (GO:0007158)4.23068088
23dermatan sulfate biosynthetic process (GO:0030208)4.21213753
24bone trabecula formation (GO:0060346)4.14746971
25ionotropic glutamate receptor signaling pathway (GO:0035235)4.12169825
26sodium ion export (GO:0071436)4.10262965
27regulation of synaptic vesicle transport (GO:1902803)3.98059777
28dermatan sulfate metabolic process (GO:0030205)3.95983652
29neurotransmitter secretion (GO:0007269)3.94464360
30synaptic transmission, glutamatergic (GO:0035249)3.91761821
31blood vessel maturation (GO:0001955)3.91045670
32cell communication by electrical coupling (GO:0010644)3.89857490
33cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.86588720
34regulation of neuronal synaptic plasticity (GO:0048168)3.86093741
35dendrite morphogenesis (GO:0048813)3.86019365
36collagen fibril organization (GO:0030199)3.84370178
37cell adhesion mediated by integrin (GO:0033627)3.83277618
38dendritic spine morphogenesis (GO:0060997)3.83144277
39glutamate receptor signaling pathway (GO:0007215)3.81812512
40regulation of long-term neuronal synaptic plasticity (GO:0048169)3.74055335
41innervation (GO:0060384)3.71876944
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.71581963
43response to pheromone (GO:0019236)3.71294303
44regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.66392205
45negative regulation of chondrocyte differentiation (GO:0032331)3.66162883
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.65390405
47gamma-aminobutyric acid transport (GO:0015812)3.60807911
48regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.60793784
49long-term memory (GO:0007616)3.60571816
50neuron-neuron synaptic transmission (GO:0007270)3.58262634
51auditory behavior (GO:0031223)3.53266943
52lymphangiogenesis (GO:0001946)3.52709901
53cell migration in hindbrain (GO:0021535)3.47852121
54planar cell polarity pathway involved in neural tube closure (GO:0090179)3.44667954
55neuron recognition (GO:0008038)3.43788676
56postsynaptic membrane organization (GO:0001941)3.43468794
57retina vasculature morphogenesis in camera-type eye (GO:0061299)3.42938261
58regulation of excitatory postsynaptic membrane potential (GO:0060079)3.42285387
59regulation of dendritic spine morphogenesis (GO:0061001)3.41979190
60axon extension involved in axon guidance (GO:0048846)3.41929057
61neuron projection extension involved in neuron projection guidance (GO:1902284)3.41929057
62cerebellar Purkinje cell differentiation (GO:0021702)3.41917435
63proline transport (GO:0015824)3.41278009
64axonal fasciculation (GO:0007413)3.40923778
65cell migration involved in heart development (GO:0060973)3.40881553
66synaptic vesicle endocytosis (GO:0048488)3.40676618
67positive regulation of membrane potential (GO:0045838)3.40669051
68G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.39518241
69response to auditory stimulus (GO:0010996)3.39062447
70negative regulation of osteoblast proliferation (GO:0033689)3.38661843
71cerebellar granule cell differentiation (GO:0021707)3.36476134
72positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.35735163
73regulation of synapse maturation (GO:0090128)3.34483526
74extracellular matrix assembly (GO:0085029)3.32288140
75regulation of postsynaptic membrane potential (GO:0060078)3.30187494
76substrate-dependent cell migration (GO:0006929)3.29937698
77cell-substrate junction assembly (GO:0007044)3.29578072
78activation of protein kinase A activity (GO:0034199)3.29470643
79neuromuscular process controlling balance (GO:0050885)3.29131694
80central nervous system projection neuron axonogenesis (GO:0021952)3.26902615
81regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.26217727
82protein heterotrimerization (GO:0070208)3.25336434
83prepulse inhibition (GO:0060134)3.24385852
84neuronal action potential propagation (GO:0019227)3.20054176
85hemidesmosome assembly (GO:0031581)3.19967464
86positive regulation of dendritic spine morphogenesis (GO:0061003)3.19191422
87positive regulation of osteoblast proliferation (GO:0033690)3.18417251
88regulation of synaptic transmission, glutamatergic (GO:0051966)3.17227163
89cellular response to vitamin (GO:0071295)3.15083534
90synapse assembly (GO:0007416)3.14590588
91gamma-aminobutyric acid signaling pathway (GO:0007214)3.13101292
92regulation of synaptic plasticity (GO:0048167)3.11031179
93regulation of neurotransmitter secretion (GO:0046928)3.10466968
94establishment of nucleus localization (GO:0040023)3.09933575
95regulation of axon extension involved in axon guidance (GO:0048841)3.09825621
96sequestering of extracellular ligand from receptor (GO:0035581)3.09751788
97cellular response to vitamin D (GO:0071305)3.09084310
98neurotransmitter transport (GO:0006836)3.08758246
99cell migration involved in sprouting angiogenesis (GO:0002042)3.08353556
100kidney mesenchyme development (GO:0072074)3.07015041
101vascular endothelial growth factor signaling pathway (GO:0038084)3.06629247
102negative regulation of cytosolic calcium ion concentration (GO:0051481)3.06433780
103pyrimidine nucleobase catabolic process (GO:0006208)3.06420723
104endothelial cell morphogenesis (GO:0001886)3.06165701
105long-term synaptic potentiation (GO:0060291)3.05352679
106regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.03851702
107stress fiber assembly (GO:0043149)3.01989695
108positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.01969859
109membrane hyperpolarization (GO:0060081)3.01538067
110transmission of nerve impulse (GO:0019226)3.00850211
111paraxial mesoderm development (GO:0048339)3.00513761
112wound healing, spreading of epidermal cells (GO:0035313)2.95109205
113potassium ion homeostasis (GO:0055075)2.93528565
114membrane depolarization during action potential (GO:0086010)2.92425063
115regulation of ARF protein signal transduction (GO:0032012)2.92093256
116regulation of osteoblast proliferation (GO:0033688)2.92051048
117regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.91518111
118mesenchymal-epithelial cell signaling (GO:0060638)2.91448323
119heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.91016028
120synapse organization (GO:0050808)2.90844185
121skin morphogenesis (GO:0043589)2.90304580
122semaphorin-plexin signaling pathway (GO:0071526)2.90294701
123positive regulation of synaptic transmission, GABAergic (GO:0032230)2.89811833
124cerebellar Purkinje cell layer development (GO:0021680)2.88406520
125positive regulation of blood vessel endothelial cell migration (GO:0043536)2.88345878
126positive regulation of dendritic spine development (GO:0060999)2.88048489
127positive regulation of axon extension (GO:0045773)2.87982720
128potassium ion import (GO:0010107)2.86555910
129cellular sodium ion homeostasis (GO:0006883)2.84465217
130negative regulation of smooth muscle cell migration (GO:0014912)2.84235426
131behavioral fear response (GO:0001662)2.83907627
132behavioral defense response (GO:0002209)2.83907627
133basement membrane organization (GO:0071711)2.83656240
134adherens junction assembly (GO:0034333)2.83419986
135dendritic spine organization (GO:0097061)2.83361690
136regulation of vesicle fusion (GO:0031338)2.83166694
137regulation of neurotransmitter transport (GO:0051588)2.82928335
138venous blood vessel morphogenesis (GO:0048845)2.82497987
139dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.82281477
140membrane depolarization (GO:0051899)2.81098829
141regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.80717281
142regulation of neurotransmitter levels (GO:0001505)2.79772942
143regulation of axon guidance (GO:1902667)2.78676094
144learning (GO:0007612)2.78231840
145neuronal ion channel clustering (GO:0045161)2.77679125
146cell communication involved in cardiac conduction (GO:0086065)2.77100230
147mechanosensory behavior (GO:0007638)2.76607663
148Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.76112901
149chondroitin sulfate biosynthetic process (GO:0030206)2.75851055
150membrane repolarization (GO:0086009)2.75618466
151regulation of voltage-gated calcium channel activity (GO:1901385)2.75350836
152collagen metabolic process (GO:0032963)2.73124051
153regulation of establishment of planar polarity (GO:0090175)2.67862983
154metanephric mesenchyme development (GO:0072075)2.65989092
155heparan sulfate proteoglycan metabolic process (GO:0030201)2.60991246
156glomerular basement membrane development (GO:0032836)2.58253619
157axon extension (GO:0048675)2.58237209
158cytoskeletal anchoring at plasma membrane (GO:0007016)2.56317211
159focal adhesion assembly (GO:0048041)2.55895181
160cell-substrate adherens junction assembly (GO:0007045)2.55895181
161collagen catabolic process (GO:0030574)2.54782578
162negative regulation of anoikis (GO:2000811)2.53601249
163apoptotic cell clearance (GO:0043277)2.53323214
164negative regulation of cartilage development (GO:0061037)2.53194829
165multicellular organismal macromolecule metabolic process (GO:0044259)2.52767591
166extracellular matrix organization (GO:0030198)2.52224602
167substrate adhesion-dependent cell spreading (GO:0034446)2.52020126
168extracellular matrix disassembly (GO:0022617)2.51281341
169extracellular structure organization (GO:0043062)2.51268964
170cardiac myofibril assembly (GO:0055003)2.50793974
171protein localization to endosome (GO:0036010)2.50489832
172pericardium development (GO:0060039)2.50470114
173G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.50019688
174chondrocyte development (GO:0002063)2.49090207
175wound healing, spreading of cells (GO:0044319)2.48969150
176negative regulation of BMP signaling pathway (GO:0030514)2.46789442
177myelination in peripheral nervous system (GO:0022011)2.46638063
178peripheral nervous system axon ensheathment (GO:0032292)2.46638063
179sprouting angiogenesis (GO:0002040)2.45071489
180glomerular visceral epithelial cell development (GO:0072015)2.45002665
181cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.44767253
182positive regulation of endothelial cell apoptotic process (GO:2000353)2.44215524
183hippo signaling (GO:0035329)2.43650850
184negative regulation of axon extension involved in axon guidance (GO:0048843)2.43037035
185barbed-end actin filament capping (GO:0051016)2.42547288
186regulation of chondrocyte differentiation (GO:0032330)2.42346310
187vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.41489351
188cortical actin cytoskeleton organization (GO:0030866)2.38310271
189blood vessel endothelial cell migration (GO:0043534)2.38047053
190chondroitin sulfate catabolic process (GO:0030207)2.37741308
191membrane assembly (GO:0071709)2.35510826
192multicellular organismal metabolic process (GO:0044236)2.35337650
193morphogenesis of an epithelial sheet (GO:0002011)2.35201577
194regulation of glucose import in response to insulin stimulus (GO:2001273)2.35174786
195positive regulation of extracellular matrix organization (GO:1903055)2.34985376
196neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.34001052
197plasma membrane repair (GO:0001778)2.33934097
198chondroitin sulfate metabolic process (GO:0030204)2.33472695
199regulation of cartilage development (GO:0061035)2.30645249
200extracellular fibril organization (GO:0043206)2.29669719

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.17914952
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.04674704
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.48407159
4GBX2_23144817_ChIP-Seq_PC3_Human3.33520256
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.30837440
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.98089598
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.96920139
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.91568219
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.83351807
10DROSHA_22980978_ChIP-Seq_HELA_Human2.73659003
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64922412
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64922412
13* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56632480
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51977745
15REST_21632747_ChIP-Seq_MESCs_Mouse2.51079627
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.50229335
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.49209855
18WT1_19549856_ChIP-ChIP_CCG9911_Human2.46989834
19* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42076344
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41798409
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.37132865
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36677403
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36440350
24* EZH2_27294783_Chip-Seq_ESCs_Mouse2.26741683
25* RNF2_27304074_Chip-Seq_ESCs_Mouse2.26505560
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.24687621
27* EED_16625203_ChIP-ChIP_MESCs_Mouse2.23176239
28BRD4_25478319_ChIP-Seq_HGPS_Human2.21418181
29SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20679087
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.15836288
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.12969688
32CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.07313571
33RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.06712406
34REST_18959480_ChIP-ChIP_MESCs_Mouse2.06646558
35AR_21572438_ChIP-Seq_LNCaP_Human2.06439153
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.96669445
37CJUN_26792858_Chip-Seq_BT549_Human1.92781446
38TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.88252405
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88059034
40CLOCK_20551151_ChIP-Seq_293T_Human1.84493747
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.83128663
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.77537557
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71491892
44TP53_18474530_ChIP-ChIP_U2OS_Human1.66796565
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64485502
46CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.64484855
47NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.62482377
48NRF2_20460467_ChIP-Seq_MEFs_Mouse1.62482377
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.57509086
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56227295
51SOX9_24532713_ChIP-Seq_HFSC_Mouse1.54743568
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52607554
53SMAD4_21799915_ChIP-Seq_A2780_Human1.51601671
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.50735545
55P300_27058665_Chip-Seq_ZR-75-30cells_Human1.50298353
56ISL1_27105846_Chip-Seq_CPCs_Mouse1.48162083
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.46743918
58SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.45449947
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44982383
60* RING1B_27294783_Chip-Seq_ESCs_Mouse1.44626520
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44576130
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.44236488
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44145474
64NFIB_24661679_ChIP-Seq_LUNG_Mouse1.44111403
65* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41617835
66TBX20_22080862_ChIP-Seq_HEART_Mouse1.40730120
67TBX20_22328084_ChIP-Seq_HEART_Mouse1.40730120
68SOX2_21211035_ChIP-Seq_LN229_Gbm1.38187475
69AR_19668381_ChIP-Seq_PC3_Human1.37457359
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35671252
71* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35212110
72* TP53_23651856_ChIP-Seq_MEFs_Mouse1.34251267
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.33776045
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.33455258
75ZNF274_21170338_ChIP-Seq_K562_Hela1.33315998
76WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32588192
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29804192
78* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28905780
79CBX2_27304074_Chip-Seq_ESCs_Mouse1.28076930
80KDM2B_26808549_Chip-Seq_K562_Human1.24947235
81ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23981371
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.23979993
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23309262
84* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.23303441
85* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.23303441
86DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22943222
87TP53_22127205_ChIP-Seq_IMR90_Human1.21337345
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18795907
89YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18781432
90NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18589222
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18060845
92NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.17636150
93RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17220751
94P300_19829295_ChIP-Seq_ESCs_Human1.16927559
95AR_25329375_ChIP-Seq_VCAP_Human1.16203974
96UBF1/2_26484160_Chip-Seq_HMECs_Human1.15910487
97STAT3_23295773_ChIP-Seq_U87_Human1.15532482
98P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14791065
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.13779100
100PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.12405950
101ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10091933
102SMC1_22415368_ChIP-Seq_MEFs_Mouse1.09571237
103EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09428067
104OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08491054
105ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08051298
106AHR_22903824_ChIP-Seq_MCF-7_Human1.07914389
107DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06502279
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06181841
109TAF15_26573619_Chip-Seq_HEK293_Human1.05975565
110ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05510138
111TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05441521
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05188132
113TCF4_23295773_ChIP-Seq_U87_Human1.05075313
114RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04963815
115SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.04734287
116TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04221216
117SMAD4_21741376_ChIP-Seq_HESCs_Human1.04187118
118PIAS1_25552417_ChIP-Seq_VCAP_Human1.04120766
119MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.04050965
120THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03887849
121ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03252596
122AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02619741
123EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02503438
124SMAD3_21741376_ChIP-Seq_HESCs_Human1.00646425
125IGF1R_20145208_ChIP-Seq_DFB_Human1.00497443
126OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00265028
127CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00105668
128MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99481525
129SMAD_19615063_ChIP-ChIP_OVARY_Human0.99260600
130UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99074220
131PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98443770
132TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98258875
133TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98015531
134SMAD3_21741376_ChIP-Seq_ESCs_Human0.97961477
135* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96553035
136TP53_16413492_ChIP-PET_HCT116_Human0.96272083
137HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96202319
138TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95656358
139SA1_22415368_ChIP-Seq_MEFs_Mouse0.95337433
140JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95201152
141TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95053762
142KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95038073
143CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91656719
144RNF2_27304074_Chip-Seq_NSC_Mouse0.91495185
145NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91386755
146GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90904638
147TP53_20018659_ChIP-ChIP_R1E_Mouse0.88518726
148GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88135303
149TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87870428
150EP300_21415370_ChIP-Seq_HL-1_Mouse0.86966694
151ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86406129
152TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.85849142

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.38042551
2MP0008438_abnormal_cutaneous_collagen6.24654092
3MP0003705_abnormal_hypodermis_morpholog4.56616812
4MP0004272_abnormal_basement_membrane3.94088994
5MP0003635_abnormal_synaptic_transmissio3.90116295
6MP0003279_aneurysm3.85689097
7MP0003880_abnormal_central_pattern3.73773773
8MP0004270_analgesia3.57678081
9MP0001958_emphysema3.40359352
10MP0005503_abnormal_tendon_morphology3.15253016
11MP0002063_abnormal_learning/memory/cond3.12845328
12MP0005275_abnormal_skin_tensile3.10499688
13MP0010368_abnormal_lymphatic_system3.05246528
14MP0009745_abnormal_behavioral_response2.91506137
15MP0005423_abnormal_somatic_nervous2.91089643
16MP0009046_muscle_twitch2.76107268
17MP0002064_seizures2.70871779
18MP0003566_abnormal_cell_adhesion2.66711027
19MP0002734_abnormal_mechanical_nocicepti2.62525623
20MP0009384_cardiac_valve_regurgitation2.59473913
21MP0005257_abnormal_intraocular_pressure2.59002923
22MP0001968_abnormal_touch/_nociception2.52897407
23MP0002572_abnormal_emotion/affect_behav2.46603563
24MP0001486_abnormal_startle_reflex2.39011822
25MP0003950_abnormal_plasma_membrane2.36877294
26MP0009780_abnormal_chondrocyte_physiolo2.29062305
27MP0002822_catalepsy2.19633304
28MP0000778_abnormal_nervous_system2.17166157
29MP0002272_abnormal_nervous_system2.15716695
30MP0010030_abnormal_orbit_morphology2.07591798
31MP0003091_abnormal_cell_migration2.04387269
32MP0002184_abnormal_innervation1.99282488
33MP0002736_abnormal_nociception_after1.98611022
34MP0000767_abnormal_smooth_muscle1.93754840
35MP0006054_spinal_hemorrhage1.91900387
36MP0004858_abnormal_nervous_system1.89823946
37MP0008569_lethality_at_weaning1.88762822
38MP0002067_abnormal_sensory_capabilities1.86516968
39MP0000569_abnormal_digit_pigmentation1.82462684
40MP0000955_abnormal_spinal_cord1.81964340
41MP0002735_abnormal_chemical_nociception1.81719793
42MP0004811_abnormal_neuron_physiology1.81246273
43MP0001984_abnormal_olfaction1.78148431
44MP0003941_abnormal_skin_development1.77490658
45MP0002733_abnormal_thermal_nociception1.75557987
46MP0004885_abnormal_endolymph1.73814376
47MP0001970_abnormal_pain_threshold1.72151477
48MP0001440_abnormal_grooming_behavior1.72072519
49MP0002557_abnormal_social/conspecific_i1.70919290
50MP0005508_abnormal_skeleton_morphology1.68987643
51MP0002882_abnormal_neuron_morphology1.56426882
52MP0000428_abnormal_craniofacial_morphol1.54721326
53MP0005023_abnormal_wound_healing1.54617241
54MP0010352_gastrointestinal_tract_polyps1.54026103
55MP0003329_amyloid_beta_deposits1.50197942
56MP0002909_abnormal_adrenal_gland1.49768464
57MP0009250_abnormal_appendicular_skeleto1.49689929
58MP0001879_abnormal_lymphatic_vessel1.49632692
59MP0004924_abnormal_behavior1.49316256
60MP0005386_behavior/neurological_phenoty1.49316256
61MP0005171_absent_coat_pigmentation1.49315218
62MP0005551_abnormal_eye_electrophysiolog1.48869844
63MP0001502_abnormal_circadian_rhythm1.48346855
64MP0001501_abnormal_sleep_pattern1.47713213
65MP0000749_muscle_degeneration1.45975541
66MP0000751_myopathy1.44080131
67MP0002060_abnormal_skin_morphology1.43988118
68MP0000733_abnormal_muscle_development1.43557973
69MP0005595_abnormal_vascular_smooth1.40660267
70MP0002896_abnormal_bone_mineralization1.38981571
71MP0002066_abnormal_motor_capabilities/c1.34268349
72MP0001542_abnormal_bone_strength1.30804705
73MP0002108_abnormal_muscle_morphology1.30630941
74MP0002877_abnormal_melanocyte_morpholog1.30150320
75MP0003122_maternal_imprinting1.29914883
76MP0005394_taste/olfaction_phenotype1.29504399
77MP0005499_abnormal_olfactory_system1.29504399
78MP0002152_abnormal_brain_morphology1.29213444
79MP0003385_abnormal_body_wall1.26905435
80MP0003879_abnormal_hair_cell1.24408427
81MP0004084_abnormal_cardiac_muscle1.22653865
82MP0005646_abnormal_pituitary_gland1.20833290
83MP0002295_abnormal_pulmonary_circulatio1.20721166
84MP0003633_abnormal_nervous_system1.18223902
85MP0000762_abnormal_tongue_morphology1.15704602
86MP0001915_intracranial_hemorrhage1.15665866
87MP0000631_abnormal_neuroendocrine_gland1.14593771
88MP0004215_abnormal_myocardial_fiber1.14342100
89MP0002090_abnormal_vision1.14287500
90MP0003942_abnormal_urinary_system1.14142782
91MP0003787_abnormal_imprinting1.14073899
92MP0003283_abnormal_digestive_organ1.13494175
93MP0009053_abnormal_anal_canal1.12735043
94MP0005645_abnormal_hypothalamus_physiol1.12006896
95MP0004233_abnormal_muscle_weight1.11039769
96MP0000049_abnormal_middle_ear1.09988704
97MP0005187_abnormal_penis_morphology1.07986353
98MP0000759_abnormal_skeletal_muscle1.06665811
99MP0000432_abnormal_head_morphology1.06665167
100MP0004145_abnormal_muscle_electrophysio1.05539283
101MP0001177_atelectasis1.05533607
102MP0005409_darkened_coat_color1.04844866
103MP0006276_abnormal_autonomic_nervous1.04003660
104MP0003137_abnormal_impulse_conducting1.03408056
105MP0003631_nervous_system_phenotype1.02983188
106MP0006072_abnormal_retinal_apoptosis1.00882670
107MP0003634_abnormal_glial_cell0.99232017
108MP0002752_abnormal_somatic_nervous0.97680282
109MP0005248_abnormal_Harderian_gland0.96987378
110MP0003935_abnormal_craniofacial_develop0.95345474
111MP0001849_ear_inflammation0.95117671
112MP0003755_abnormal_palate_morphology0.93361154
113MP0004134_abnormal_chest_morphology0.93339087
114MP0004085_abnormal_heartbeat0.92778575
115MP0004036_abnormal_muscle_relaxation0.91913653
116MP0003115_abnormal_respiratory_system0.90799225
117MP0000462_abnormal_digestive_system0.90368618
118MP0002116_abnormal_craniofacial_bone0.90048659
119MP0003861_abnormal_nervous_system0.89871692
120MP0001348_abnormal_lacrimal_gland0.89602237
121MP0005623_abnormal_meninges_morphology0.89313353
122MP0002229_neurodegeneration0.88777094
123MP0000163_abnormal_cartilage_morphology0.88427845
124MP0002128_abnormal_blood_circulation0.88331666
125MP0002925_abnormal_cardiovascular_devel0.87819342
126MP0003632_abnormal_nervous_system0.87391473
127MP0001614_abnormal_blood_vessel0.87146432
128MP0005197_abnormal_uvea_morphology0.86401306
129MP0005253_abnormal_eye_physiology0.85977256
130MP0001243_abnormal_dermal_layer0.85268388
131MP0003045_fibrosis0.85087649
132MP0002069_abnormal_eating/drinking_beha0.84415948
133MP0002932_abnormal_joint_morphology0.84402074
134MP0008961_abnormal_basal_metabolism0.83204907
135MP0008789_abnormal_olfactory_epithelium0.82169963
136MP0002254_reproductive_system_inflammat0.81904829
137MP0010386_abnormal_urinary_bladder0.81645104
138MP0006138_congestive_heart_failure0.81619971
139MP0002168_other_aberrant_phenotype0.81290720
140MP0001299_abnormal_eye_distance/0.80430864
141MP0004087_abnormal_muscle_fiber0.80173110
142MP0002653_abnormal_ependyma_morphology0.80013340
143MP0004142_abnormal_muscle_tone0.79932030
144MP0002114_abnormal_axial_skeleton0.79599650
145MP0000537_abnormal_urethra_morphology0.78314262
146MP0001963_abnormal_hearing_physiology0.78187617
147MP0003300_gastrointestinal_ulcer0.76152497
148MP0002697_abnormal_eye_size0.76058555
149MP0002234_abnormal_pharynx_morphology0.75943778
150MP0004742_abnormal_vestibular_system0.75853728
151MP0002115_abnormal_skeleton_extremities0.75638836
152MP0002089_abnormal_postnatal_growth/wei0.75314750
153MP0005620_abnormal_muscle_contractility0.74309099
154MP0005388_respiratory_system_phenotype0.73829400
155MP0002133_abnormal_respiratory_system0.73829400
156MP0000534_abnormal_ureter_morphology0.73460571
157MP0001529_abnormal_vocalization0.73276191
158MP0000013_abnormal_adipose_tissue0.70658165
159MP0002638_abnormal_pupillary_reflex0.67844568
160MP0006292_abnormal_olfactory_placode0.67631334
161MP0003690_abnormal_glial_cell0.65656226
162MP0003119_abnormal_digestive_system0.65546125
163MP0002113_abnormal_skeleton_development0.65396685
164MP0003937_abnormal_limbs/digits/tail_de0.64932115
165MP0005390_skeleton_phenotype0.64485478
166MP0002249_abnormal_larynx_morphology0.63949290
167MP0000750_abnormal_muscle_regeneration0.62816447
168MP0000747_muscle_weakness0.62483285
169MP0005076_abnormal_cell_differentiation0.62442345
170MP0001175_abnormal_lung_morphology0.62141330
171MP0005195_abnormal_posterior_eye0.61882163
172MP0000003_abnormal_adipose_tissue0.61634290
173MP0010769_abnormal_survival0.60705043
174MP0000538_abnormal_urinary_bladder0.60310534
175MP0001905_abnormal_dopamine_level0.59866507
176MP0000467_abnormal_esophagus_morphology0.59587486
177MP0002082_postnatal_lethality0.59512446
178MP0010770_preweaning_lethality0.59512446
179MP0002092_abnormal_eye_morphology0.58931977
180MP0002837_dystrophic_cardiac_calcinosis0.58930191
181MP0001943_abnormal_respiration0.58900566
182MP0000920_abnormal_myelination0.58501462
183MP0000026_abnormal_inner_ear0.58062194
184MP0002081_perinatal_lethality0.57356057
185MP0000266_abnormal_heart_morphology0.56530112

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.21178215
2Premature rupture of membranes (HP:0001788)5.72834187
3Myokymia (HP:0002411)5.53462485
4Focal motor seizures (HP:0011153)5.19867224
5Aortic aneurysm (HP:0004942)4.41865314
6Focal seizures (HP:0007359)4.32165716
7Epileptic encephalopathy (HP:0200134)4.28761676
8Ankle contracture (HP:0006466)4.05435573
9Action tremor (HP:0002345)4.04831669
10Aortic dissection (HP:0002647)4.03220255
11Progressive cerebellar ataxia (HP:0002073)3.98441636
12Visual hallucinations (HP:0002367)3.95549521
13Broad metatarsal (HP:0001783)3.87046589
14Vascular tortuosity (HP:0004948)3.77660203
15Bladder diverticulum (HP:0000015)3.60262909
16Arterial tortuosity (HP:0005116)3.54367725
17Spinal rigidity (HP:0003306)3.43771279
18Febrile seizures (HP:0002373)3.24757834
19Supranuclear gaze palsy (HP:0000605)3.16274678
20Neonatal short-limb short stature (HP:0008921)3.13161968
21Overgrowth (HP:0001548)3.09986291
22Abnormality of dentin (HP:0010299)3.09611596
23Wormian bones (HP:0002645)3.03206197
24Atrophic scars (HP:0001075)3.02569891
25Aortic regurgitation (HP:0001659)3.02131730
26Megalencephaly (HP:0001355)2.97606576
27Broad-based gait (HP:0002136)2.97366057
28Type 1 muscle fiber predominance (HP:0003803)2.96674907
29Follicular hyperkeratosis (HP:0007502)2.95779672
30Poor eye contact (HP:0000817)2.95160840
31Ankle clonus (HP:0011448)2.92431054
32Dysdiadochokinesis (HP:0002075)2.92343495
33Absence seizures (HP:0002121)2.91628477
34Soft skin (HP:0000977)2.89468821
35Increased variability in muscle fiber diameter (HP:0003557)2.86841506
36Cervical subluxation (HP:0003308)2.85481582
37Depression (HP:0000716)2.82838741
38Bowel diverticulosis (HP:0005222)2.82454376
39Hemiparesis (HP:0001269)2.80135653
40Atonic seizures (HP:0010819)2.76797561
41Mutism (HP:0002300)2.76679538
42Generalized tonic-clonic seizures (HP:0002069)2.76208941
43Mitral regurgitation (HP:0001653)2.75844942
44Genetic anticipation (HP:0003743)2.73861422
45Gaze-evoked nystagmus (HP:0000640)2.66840002
46Genu recurvatum (HP:0002816)2.66804919
47Abnormal social behavior (HP:0012433)2.66213623
48Impaired social interactions (HP:0000735)2.66213623
49Wrist flexion contracture (HP:0001239)2.66124738
50Spondylolisthesis (HP:0003302)2.65439957
51Dialeptic seizures (HP:0011146)2.61758042
52Truncal ataxia (HP:0002078)2.61436119
53Hemiplegia (HP:0002301)2.61352798
54Mitral valve prolapse (HP:0001634)2.60880993
55Drooling (HP:0002307)2.59528781
56Excessive salivation (HP:0003781)2.59528781
57Urinary bladder sphincter dysfunction (HP:0002839)2.59061884
58Flat cornea (HP:0007720)2.58727228
59Torticollis (HP:0000473)2.58577817
60Ulnar bowing (HP:0003031)2.53458045
61Epileptiform EEG discharges (HP:0011182)2.52163294
62Impaired vibration sensation in the lower limbs (HP:0002166)2.51891293
63EEG with generalized epileptiform discharges (HP:0011198)2.51383403
64Vertebral compression fractures (HP:0002953)2.51315744
65Dilatation of the ascending aorta (HP:0005111)2.48797147
66Renal duplication (HP:0000075)2.46876549
67Hyperventilation (HP:0002883)2.46355531
68Abnormality of the lower motor neuron (HP:0002366)2.42737377
69Fragile skin (HP:0001030)2.41619403
70Coronal craniosynostosis (HP:0004440)2.38709450
71Postural instability (HP:0002172)2.37830779
72Dysmetria (HP:0001310)2.36173316
73Hypsarrhythmia (HP:0002521)2.35539646
74Dysmetric saccades (HP:0000641)2.35149674
75Abnormality of skeletal muscle fiber size (HP:0012084)2.35136819
76Blue sclerae (HP:0000592)2.34480789
77Joint laxity (HP:0001388)2.32843861
78Anxiety (HP:0000739)2.31827753
79Diplopia (HP:0000651)2.31272484
80Abnormality of binocular vision (HP:0011514)2.31272484
81Focal dystonia (HP:0004373)2.31249777
82Fetal akinesia sequence (HP:0001989)2.28135221
83Hyperextensible skin (HP:0000974)2.26070998
84Slender build (HP:0001533)2.25604008
85Pointed chin (HP:0000307)2.24249167
86Abnormal eating behavior (HP:0100738)2.22985785
87Impaired smooth pursuit (HP:0007772)2.22634836
88Mitral stenosis (HP:0001718)2.20888811
89Biconcave vertebral bodies (HP:0004586)2.19721630
90Broad ribs (HP:0000885)2.19130547
91Limb dystonia (HP:0002451)2.18601114
92Cerebral aneurysm (HP:0004944)2.17583314
93Wide anterior fontanel (HP:0000260)2.17394175
94Natal tooth (HP:0000695)2.17369859
95Insomnia (HP:0100785)2.16395302
96Urinary urgency (HP:0000012)2.15816319
97Aortic valve stenosis (HP:0001650)2.14175413
98Spastic gait (HP:0002064)2.13771715
99Central scotoma (HP:0000603)2.13187096
100Disproportionate tall stature (HP:0001519)2.13091632
101Hepatoblastoma (HP:0002884)2.12622427
102Prolonged QT interval (HP:0001657)2.12030094
103Papilledema (HP:0001085)2.11684719
104Increased connective tissue (HP:0009025)2.10982269
105Stereotypic behavior (HP:0000733)2.10771723
106Craniofacial dystonia (HP:0012179)2.10641032
107Camptodactyly of toe (HP:0001836)2.10390816
108Obstructive sleep apnea (HP:0002870)2.10179868
109Spinal cord lesions (HP:0100561)2.09778434
110Syringomyelia (HP:0003396)2.09778434
111Mildly elevated creatine phosphokinase (HP:0008180)2.05999892
112Ventricular fibrillation (HP:0001663)2.05589659
113Hypoventilation (HP:0002791)2.05513192
114Aneurysm (HP:0002617)2.03948126
115Bradykinesia (HP:0002067)2.03023911
116Neurofibrillary tangles (HP:0002185)2.02976944
117Overriding aorta (HP:0002623)2.01289031
118Renovascular hypertension (HP:0100817)2.01163980
119Short nail (HP:0001799)2.00579404
120Intention tremor (HP:0002080)2.00125161
121Aqueductal stenosis (HP:0002410)2.00000159
122Agitation (HP:0000713)1.99656363
123Abnormality of ocular smooth pursuit (HP:0000617)1.99217518
124Osteolytic defects of the hand bones (HP:0009699)1.97829292
125Osteolytic defects of the phalanges of the hand (HP:0009771)1.97829292
126Arnold-Chiari malformation (HP:0002308)1.97457910
127Aplasia involving bones of the extremities (HP:0009825)1.96692676
128Aplasia involving bones of the upper limbs (HP:0009823)1.96692676
129Aplasia of the phalanges of the hand (HP:0009802)1.96692676
130Insidious onset (HP:0003587)1.94784399
131Termporal pattern (HP:0011008)1.94784399
132Cerebral inclusion bodies (HP:0100314)1.94580516
133Septo-optic dysplasia (HP:0100842)1.94432032
134Congenital stationary night blindness (HP:0007642)1.94192840
135Abnormal EKG (HP:0003115)1.93705832
136Mild short stature (HP:0003502)1.93640204
137Amblyopia (HP:0000646)1.93423453
138Amyotrophic lateral sclerosis (HP:0007354)1.93056712
139Limited hip movement (HP:0008800)1.92837979
140Hypoplasia of the iris (HP:0007676)1.92534701
141Lower limb amyotrophy (HP:0007210)1.91024143
142Scanning speech (HP:0002168)1.88264043
143Lower limb muscle weakness (HP:0007340)1.87673037
144Elbow flexion contracture (HP:0002987)1.87663166
145Vertebral arch anomaly (HP:0008438)1.87107627
146Incomplete penetrance (HP:0003829)1.86619797
147Ectopia lentis (HP:0001083)1.86027929
148Abnormality of the corticospinal tract (HP:0002492)1.85995129
149Turricephaly (HP:0000262)1.85768124
150Pulmonic stenosis (HP:0001642)1.85603235
151Round ear (HP:0100830)1.85424532
152Abnormality of the acetabulum (HP:0003170)1.84335997
153Abnormality of the astrocytes (HP:0100707)1.84086407
154Astrocytoma (HP:0009592)1.84086407
155Hydroureter (HP:0000072)1.82982175
156Shallow orbits (HP:0000586)1.82212234
157Neoplasm of the heart (HP:0100544)1.81481604
158Deviation of the hallux (HP:0010051)1.79982892
159Bundle branch block (HP:0011710)1.79943912
160Absent speech (HP:0001344)1.78252331
161Hallux valgus (HP:0001822)1.77191702
162Impaired vibratory sensation (HP:0002495)1.75551402
163Pulmonary artery stenosis (HP:0004415)1.74835221
164Thin ribs (HP:0000883)1.74785555
165Broad long bones (HP:0005622)1.74383106
166Tibial bowing (HP:0002982)1.73937204
167Megalocornea (HP:0000485)1.73303878
168Pheochromocytoma (HP:0002666)1.72227742
169Inappropriate behavior (HP:0000719)1.72013561
170Joint contractures involving the joints of the feet (HP:0100492)1.70661151
171Flexion contracture of toe (HP:0005830)1.70661151
172Abnormality of the anterior chamber (HP:0000593)1.68782462
173Annular pancreas (HP:0001734)1.68442217
174Elfin facies (HP:0004428)1.68170970
175Postural tremor (HP:0002174)1.68122317
176Akinesia (HP:0002304)1.67913910
177Limb-girdle muscle weakness (HP:0003325)1.67726211
178Absent frontal sinuses (HP:0002688)1.67630315
179Polyphagia (HP:0002591)1.67393889
180Advanced eruption of teeth (HP:0006288)1.67358391
181Asymmetry of the thorax (HP:0001555)1.67040197
182Abnormality of salivation (HP:0100755)1.66176376
183Mesomelia (HP:0003027)1.65532980
184Generalized amyotrophy (HP:0003700)1.65493480
185Buphthalmos (HP:0000557)1.64967487
186Bronchomalacia (HP:0002780)1.64965570
187Genu valgum (HP:0002857)1.64145219
188Knee flexion contracture (HP:0006380)1.64119581
189Hyperacusis (HP:0010780)1.64067937
190Neoplasm of the peripheral nervous system (HP:0100007)1.63630415
191Congenital glaucoma (HP:0001087)1.63223511
192Long toe (HP:0010511)1.62754123

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.87734013
2EPHA43.66283487
3NTRK33.48847185
4TTN3.47724430
5MAP3K93.33984526
6MYLK2.98793036
7NEK92.77036327
8PAK62.60468954
9NTRK22.56243147
10MINK12.55036637
11TIE12.48283522
12PTK22.47040272
13MAP3K42.39668153
14DAPK22.33431452
15PRKD32.20022267
16PHKG22.03445913
17PHKG12.03445913
18MAP2K72.00299955
19TGFBR21.99863248
20LATS11.98525256
21PRPF4B1.91796277
22CAMKK11.90526311
23PAK21.86872793
24TRIB31.77314334
25PDGFRB1.73343262
26TNIK1.69202685
27EEF2K1.69192384
28AKT31.69061630
29LIMK11.65423649
30MET1.65020696
31MAPK131.64578978
32KSR21.61483020
33KSR11.61323701
34STK381.53485052
35CDK51.51594069
36NTRK11.51395335
37MOS1.49393253
38MAP3K101.38410831
39PRKD21.37098875
40TYRO31.30182361
41PAK41.29767370
42RIPK11.27729064
43MAP3K21.26671266
44FLT31.22055179
45DAPK11.21943471
46MAP2K41.20833370
47LATS21.20688938
48MAPK71.20543793
49LMTK21.17528152
50SIK21.17503497
51CAMK1D1.15536432
52SIK11.14272103
53ERBB31.14217650
54CDK121.13598741
55MTOR1.13400919
56CASK1.11705780
57TESK11.09674718
58TRPM71.08896318
59PRKCG1.07927720
60PAK31.07362380
61PKN21.06854537
62NEK11.04672816
63SGK2231.01836020
64SGK4941.01836020
65MARK21.01768258
66PLK21.01383353
67DYRK1A0.98691739
68CAMKK20.98487143
69UHMK10.96711942
70PRKCH0.96516018
71CDK150.92734215
72CDK180.92573776
73ALK0.91207159
74MELK0.90620497
75CDK140.87606691
76CSNK1G20.86740712
77CAMK10.85775356
78TAOK10.85121295
79SGK20.85028890
80RET0.84220038
81STK110.82471580
82SMG10.82464841
83SGK30.82169685
84CDK80.80747548
85ERBB40.79115330
86CDK11A0.78445049
87CAMK1G0.77187241
88DYRK20.77006159
89CAMK2A0.76940076
90PTK2B0.75319695
91FGFR20.74188986
92FER0.74084169
93CDC42BPA0.73379301
94PIK3CG0.71129756
95CDK190.70161171
96GRK50.69601029
97STK38L0.68804925
98SGK10.68073177
99PRKG20.67188971
100DMPK0.66991049
101FES0.66424188
102PKN10.64129740
103PDGFRA0.64040109
104STK30.62688519
105PRKCZ0.61177406
106CAMK40.60911050
107BMX0.60553652
108DDR20.58901734
109CAMK2G0.57795462
110DAPK30.57774584
111MAP3K60.57099443
112CAMK2B0.56899118
113RPS6KC10.55816952
114RPS6KL10.55816952
115RPS6KA30.55803300
116EPHB20.54243585
117CSNK1A1L0.53314647
118PRKCE0.52549947
119FYN0.52235005
120CDK90.52222769
121PNCK0.51175312
122GSK3A0.51016469
123NEK60.48272810
124MAPK100.47775189
125ABL20.46651518
126RIPK40.45884133
127WNK30.45734402
128CAMK2D0.45657800
129BRD40.45023196
130MAPK120.44829826
131ERBB20.44800628
132PRKD10.42943827
133ICK0.42913924
134CLK10.42725690
135MAP3K70.42538819
136CSNK1G30.42147721
137INSR0.41168258
138PRKAA10.40697434
139GRK70.40249116
140ERN10.39767692
141SRC0.39756386
142RPS6KA20.39697708
143TGFBR10.39561728
144MAPK90.38354412
145PDK10.37986560
146MAPK80.37675585
147DYRK1B0.37525405
148ROCK10.37481193
149RPS6KA60.36258967
150MAP2K10.36045453
151WNK10.35934187
152FGFR10.35278858
153ROCK20.35252987
154GSK3B0.35220817
155EPHA30.34841155
156PDPK10.34837703
157ADRBK10.30881425

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.43078292
2Nicotine addiction_Homo sapiens_hsa050333.36396566
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.90653001
4Synaptic vesicle cycle_Homo sapiens_hsa047212.90056237
5GABAergic synapse_Homo sapiens_hsa047272.67416314
6Focal adhesion_Homo sapiens_hsa045102.65827135
7Circadian entrainment_Homo sapiens_hsa047132.63425738
8Olfactory transduction_Homo sapiens_hsa047402.48496521
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.45023116
10Morphine addiction_Homo sapiens_hsa050322.43088640
11Glutamatergic synapse_Homo sapiens_hsa047242.42892281
12Long-term potentiation_Homo sapiens_hsa047202.23754280
13Insulin secretion_Homo sapiens_hsa049112.02845360
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.01530217
15Salivary secretion_Homo sapiens_hsa049702.00983822
16Amphetamine addiction_Homo sapiens_hsa050311.97294260
17Cholinergic synapse_Homo sapiens_hsa047251.95088404
18Dopaminergic synapse_Homo sapiens_hsa047281.93374862
19Adherens junction_Homo sapiens_hsa045201.85912722
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79282390
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.77558309
22Gastric acid secretion_Homo sapiens_hsa049711.72045344
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.64879729
24Renin secretion_Homo sapiens_hsa049241.63685190
25Oxytocin signaling pathway_Homo sapiens_hsa049211.63477077
26MicroRNAs in cancer_Homo sapiens_hsa052061.59041555
27Regulation of actin cytoskeleton_Homo sapiens_hsa048101.54576750
28Taste transduction_Homo sapiens_hsa047421.53237300
29AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.51964432
30Long-term depression_Homo sapiens_hsa047301.51713570
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.50357049
32Amoebiasis_Homo sapiens_hsa051461.48776199
33Small cell lung cancer_Homo sapiens_hsa052221.48175750
34Axon guidance_Homo sapiens_hsa043601.46737445
35Gap junction_Homo sapiens_hsa045401.46560560
36Cocaine addiction_Homo sapiens_hsa050301.46472085
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45676887
38Calcium signaling pathway_Homo sapiens_hsa040201.40428119
39Bladder cancer_Homo sapiens_hsa052191.39941495
40Type II diabetes mellitus_Homo sapiens_hsa049301.36771721
41Protein digestion and absorption_Homo sapiens_hsa049741.35156845
42Serotonergic synapse_Homo sapiens_hsa047261.34864919
43Chronic myeloid leukemia_Homo sapiens_hsa052201.30676986
44GnRH signaling pathway_Homo sapiens_hsa049121.29971032
45TGF-beta signaling pathway_Homo sapiens_hsa043501.28727393
46cAMP signaling pathway_Homo sapiens_hsa040241.27220315
47Melanoma_Homo sapiens_hsa052181.26308692
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25932151
49Glioma_Homo sapiens_hsa052141.25329520
50PI3K-Akt signaling pathway_Homo sapiens_hsa041511.24706236
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23818039
52Dilated cardiomyopathy_Homo sapiens_hsa054141.16792681
53Estrogen signaling pathway_Homo sapiens_hsa049151.16551965
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14415273
55Pathways in cancer_Homo sapiens_hsa052001.13006999
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12930817
57ErbB signaling pathway_Homo sapiens_hsa040121.09653554
58Melanogenesis_Homo sapiens_hsa049161.08651984
59Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05241921
60Notch signaling pathway_Homo sapiens_hsa043301.04978474
61Nitrogen metabolism_Homo sapiens_hsa009101.03014918
62Endometrial cancer_Homo sapiens_hsa052131.01172629
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.01099776
64Prostate cancer_Homo sapiens_hsa052150.98689165
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97972874
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.94410636
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93190826
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92281328
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.89064139
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.86620824
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86484602
72Phototransduction_Homo sapiens_hsa047440.86383160
73Pancreatic cancer_Homo sapiens_hsa052120.85576353
74Cardiac muscle contraction_Homo sapiens_hsa042600.85094526
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84471050
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83222718
77Lysine degradation_Homo sapiens_hsa003100.82918106
78Choline metabolism in cancer_Homo sapiens_hsa052310.80633767
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80592779
80Oocyte meiosis_Homo sapiens_hsa041140.78690057
81Collecting duct acid secretion_Homo sapiens_hsa049660.77725241
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76558406
83Circadian rhythm_Homo sapiens_hsa047100.76503548
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76163202
85Pancreatic secretion_Homo sapiens_hsa049720.76101096
86AMPK signaling pathway_Homo sapiens_hsa041520.73037432
87Colorectal cancer_Homo sapiens_hsa052100.73020043
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72694908
89Thyroid cancer_Homo sapiens_hsa052160.72027930
90MAPK signaling pathway_Homo sapiens_hsa040100.71331325
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70794114
92Thyroid hormone synthesis_Homo sapiens_hsa049180.70493965
93Wnt signaling pathway_Homo sapiens_hsa043100.69693719
94Dorso-ventral axis formation_Homo sapiens_hsa043200.68471072
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.67727145
96Renal cell carcinoma_Homo sapiens_hsa052110.66693221
97VEGF signaling pathway_Homo sapiens_hsa043700.66092860
98mTOR signaling pathway_Homo sapiens_hsa041500.65627853
99Rap1 signaling pathway_Homo sapiens_hsa040150.64823341
100Platelet activation_Homo sapiens_hsa046110.64734205
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62572905
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61490643
103Glucagon signaling pathway_Homo sapiens_hsa049220.61319965
104Ras signaling pathway_Homo sapiens_hsa040140.59743743
105Vibrio cholerae infection_Homo sapiens_hsa051100.57623696
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57114698
107Non-small cell lung cancer_Homo sapiens_hsa052230.56379793
108Alcoholism_Homo sapiens_hsa050340.55207466
109p53 signaling pathway_Homo sapiens_hsa041150.53506944
110Hippo signaling pathway_Homo sapiens_hsa043900.51941125
111Malaria_Homo sapiens_hsa051440.51845207
112Insulin signaling pathway_Homo sapiens_hsa049100.50825697
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.50733657
114Endocytosis_Homo sapiens_hsa041440.50529034
115Hedgehog signaling pathway_Homo sapiens_hsa043400.50443418
116Bile secretion_Homo sapiens_hsa049760.50341736
117FoxO signaling pathway_Homo sapiens_hsa040680.49984900
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.49200197
119Other glycan degradation_Homo sapiens_hsa005110.49034048
120Prolactin signaling pathway_Homo sapiens_hsa049170.48468020
121Inositol phosphate metabolism_Homo sapiens_hsa005620.48372021
122Shigellosis_Homo sapiens_hsa051310.48188980
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47873401
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47164537
125Basal cell carcinoma_Homo sapiens_hsa052170.44132211
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43282560
127Tight junction_Homo sapiens_hsa045300.42033572
128Prion diseases_Homo sapiens_hsa050200.38547780
129Proteoglycans in cancer_Homo sapiens_hsa052050.38053384
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34597397
131Ovarian steroidogenesis_Homo sapiens_hsa049130.34514613
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34363814
133Chemokine signaling pathway_Homo sapiens_hsa040620.34042252
134Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33737670

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »