PCDHGA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)5.65816793
2synaptic vesicle maturation (GO:0016188)5.19862768
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.92151448
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.84821251
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.63688430
6vocalization behavior (GO:0071625)4.57885499
7layer formation in cerebral cortex (GO:0021819)4.53197882
8synaptic vesicle docking involved in exocytosis (GO:0016081)4.42904384
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.41294881
10exploration behavior (GO:0035640)4.37256524
11glutamate secretion (GO:0014047)4.23254585
12synaptic vesicle exocytosis (GO:0016079)4.18401971
13cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.18156469
14regulation of glutamate receptor signaling pathway (GO:1900449)4.15280718
15protein localization to synapse (GO:0035418)4.12354709
16regulation of synapse structural plasticity (GO:0051823)4.09489227
17cell communication by electrical coupling (GO:0010644)4.06017117
18regulation of synaptic vesicle exocytosis (GO:2000300)3.92551185
19dendritic spine morphogenesis (GO:0060997)3.89490871
20membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.74510602
21neurotransmitter-gated ion channel clustering (GO:0072578)3.63954591
22neuron cell-cell adhesion (GO:0007158)3.60852824
23sodium ion export (GO:0071436)3.59012902
24neurotransmitter secretion (GO:0007269)3.58528495
25regulation of long-term neuronal synaptic plasticity (GO:0048169)3.55687523
26positive regulation of synapse maturation (GO:0090129)3.53798215
27regulation of neuronal synaptic plasticity (GO:0048168)3.53790340
28dendrite morphogenesis (GO:0048813)3.53510813
29ionotropic glutamate receptor signaling pathway (GO:0035235)3.50350667
30regulation of synaptic vesicle transport (GO:1902803)3.45233302
31activation of protein kinase A activity (GO:0034199)3.44987106
32proline transport (GO:0015824)3.38732856
33long-term memory (GO:0007616)3.35197695
34regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.34026996
35cellular potassium ion homeostasis (GO:0030007)3.30655058
36cell migration in hindbrain (GO:0021535)3.29824944
37extracellular matrix assembly (GO:0085029)3.27474890
38regulation of axon extension involved in axon guidance (GO:0048841)3.25943538
39axonal fasciculation (GO:0007413)3.24484431
40synaptic transmission, glutamatergic (GO:0035249)3.20907966
41cell communication involved in cardiac conduction (GO:0086065)3.20790282
42protein heterotrimerization (GO:0070208)3.20077891
43postsynaptic membrane organization (GO:0001941)3.19972231
44neuromuscular process controlling balance (GO:0050885)3.18340895
45regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.17917020
46glutamate receptor signaling pathway (GO:0007215)3.17364851
47regulation of dendritic spine morphogenesis (GO:0061001)3.16684534
48auditory behavior (GO:0031223)3.15510349
49regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.14068430
50gamma-aminobutyric acid transport (GO:0015812)3.12674977
51peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.12249765
52neuron recognition (GO:0008038)3.12208227
53regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.11442000
54innervation (GO:0060384)3.11189259
55response to auditory stimulus (GO:0010996)3.10524479
56positive regulation of membrane potential (GO:0045838)3.10127071
57regulation of excitatory postsynaptic membrane potential (GO:0060079)3.07952076
58neuronal action potential propagation (GO:0019227)3.05256885
59collagen fibril organization (GO:0030199)3.03080171
60type B pancreatic cell proliferation (GO:0044342)3.01556632
61establishment of nucleus localization (GO:0040023)3.01534198
62neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.01222310
63skin morphogenesis (GO:0043589)2.98374332
64neuron-neuron synaptic transmission (GO:0007270)2.96767566
65regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.96420105
66regulation of postsynaptic membrane potential (GO:0060078)2.95275284
67cerebellar Purkinje cell differentiation (GO:0021702)2.95002601
68myelination in peripheral nervous system (GO:0022011)2.91120535
69peripheral nervous system axon ensheathment (GO:0032292)2.91120535
70G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.88681028
71positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.87080857
72central nervous system projection neuron axonogenesis (GO:0021952)2.86697001
73cerebellar granule cell differentiation (GO:0021707)2.86399005
74sequestering of extracellular ligand from receptor (GO:0035581)2.86222719
75positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.84170442
76regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.82293700
77synaptic vesicle endocytosis (GO:0048488)2.81940170
78regulation of synaptic plasticity (GO:0048167)2.81776189
79regulation of synapse maturation (GO:0090128)2.78459999
80cerebellar Purkinje cell layer development (GO:0021680)2.78018063
81regulation of axon guidance (GO:1902667)2.77704927
82cell migration involved in heart development (GO:0060973)2.77235842
83negative regulation of cytosolic calcium ion concentration (GO:0051481)2.76946641
84regulation of type B pancreatic cell apoptotic process (GO:2000674)2.76735045
85regulation of membrane repolarization (GO:0060306)2.76337792
86potassium ion import (GO:0010107)2.75627048
87endocardial cushion development (GO:0003197)2.74972008
88regulation of neurotransmitter secretion (GO:0046928)2.74331527
89membrane depolarization during action potential (GO:0086010)2.73692846
90regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.73495560
91positive regulation of potassium ion transmembrane transport (GO:1901381)2.73012529
92negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.72667077
93neurotransmitter transport (GO:0006836)2.71321090
94long-term synaptic potentiation (GO:0060291)2.70025417
95positive regulation of dendritic spine morphogenesis (GO:0061003)2.68532877
96regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.67592364
97vesicle transport along microtubule (GO:0047496)2.67504697
98chemosensory behavior (GO:0007635)2.66716763
99dendritic spine organization (GO:0097061)2.66559814
100positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.66455095
101extracellular fibril organization (GO:0043206)2.65565537
102organelle transport along microtubule (GO:0072384)2.65470740
103neuronal ion channel clustering (GO:0045161)2.65295797
104membrane repolarization (GO:0086009)2.65051568
105glomerular basement membrane development (GO:0032836)2.64902747
106myoblast fusion (GO:0007520)2.64104866
107membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.63434845
108synapse organization (GO:0050808)2.62513984
109regulation of ARF protein signal transduction (GO:0032012)2.62456539
110cellular sodium ion homeostasis (GO:0006883)2.62360382
111regulation of synaptic transmission, glutamatergic (GO:0051966)2.62285411
112regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.61193744
113positive regulation of synaptic transmission, GABAergic (GO:0032230)2.60848398
114cell adhesion mediated by integrin (GO:0033627)2.60480879
115synapse assembly (GO:0007416)2.60456613
116prepulse inhibition (GO:0060134)2.60150784
117regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.59611826
118positive regulation of neurotransmitter secretion (GO:0001956)2.59268494
119regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.59199995
120mesenchymal-epithelial cell signaling (GO:0060638)2.57959335
121chondrocyte proliferation (GO:0035988)2.57203734
122neuromuscular process (GO:0050905)2.56788781
123kidney mesenchyme development (GO:0072074)2.56199715
124regulation of dendritic spine development (GO:0060998)2.55513603
125heparin biosynthetic process (GO:0030210)2.52934617
126heparin metabolic process (GO:0030202)2.52934617
127cardiac myofibril assembly (GO:0055003)2.52805391
128dermatan sulfate biosynthetic process (GO:0030208)2.49702114
129regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.49027802
130positive regulation of axon extension (GO:0045773)2.45731143
131protein retention in ER lumen (GO:0006621)2.45293229
132endodermal cell differentiation (GO:0035987)2.44521468
133dermatan sulfate metabolic process (GO:0030205)2.43943788
134vascular endothelial growth factor signaling pathway (GO:0038084)2.39789282
135positive regulation of cardiac muscle hypertrophy (GO:0010613)2.39094026
136positive regulation of muscle hypertrophy (GO:0014742)2.39094026
137bone trabecula formation (GO:0060346)2.36469962
138endocytic recycling (GO:0032456)2.36278526
139maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.36235319
140cellular response to vitamin (GO:0071295)2.35210268
141insulin-like growth factor receptor signaling pathway (GO:0048009)2.34898226
142keratan sulfate catabolic process (GO:0042340)2.34660402
143regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.34405696
144chondroitin sulfate catabolic process (GO:0030207)2.34363743
145regulation of glucocorticoid metabolic process (GO:0031943)2.34139379
146cytoskeletal anchoring at plasma membrane (GO:0007016)2.32579177
147negative regulation of hormone biosynthetic process (GO:0032353)2.30248467
148myofibril assembly (GO:0030239)2.28086595
149syncytium formation by plasma membrane fusion (GO:0000768)2.28050734
150cell-substrate junction assembly (GO:0007044)2.27661820
151detection of calcium ion (GO:0005513)2.27266926
152astrocyte development (GO:0014002)2.26581466
153smooth muscle tissue development (GO:0048745)2.24735744
154metanephric mesenchyme development (GO:0072075)2.24363563
155actomyosin structure organization (GO:0031032)2.20757466
156regulation of the force of heart contraction (GO:0002026)2.19209548
157negative regulation of axon extension involved in axon guidance (GO:0048843)2.19199583
158axon extension (GO:0048675)2.15527807
159urinary tract smooth muscle contraction (GO:0014848)2.15522230
160COPI coating of Golgi vesicle (GO:0048205)2.14795126
161Golgi transport vesicle coating (GO:0048200)2.14795126
162cellular response to vitamin D (GO:0071305)2.14573566
163regulation of integrin-mediated signaling pathway (GO:2001044)2.13116082
164protein localization to cell surface (GO:0034394)2.12687223
165stress fiber assembly (GO:0043149)2.12452254
166regulation of transforming growth factor beta1 production (GO:0032908)2.11613661
167positive regulation of osteoblast proliferation (GO:0033690)2.10486565
168negative regulation of protein localization to cell surface (GO:2000009)2.09013618
169fibril organization (GO:0097435)2.08836579
170COPII vesicle coating (GO:0048208)2.08829448
171regulation of cell communication by electrical coupling (GO:0010649)2.07391028
172collagen metabolic process (GO:0032963)2.07375581
173hemidesmosome assembly (GO:0031581)2.07298348
174virion attachment to host cell (GO:0019062)2.07267933
175adhesion of symbiont to host cell (GO:0044650)2.07267933
176negative regulation of chondrocyte differentiation (GO:0032331)2.06651486
177fibroblast migration (GO:0010761)2.05766165
178semaphorin-plexin signaling pathway (GO:0071526)2.04612307
179desmosome organization (GO:0002934)2.04194326
180sarcomere organization (GO:0045214)2.03745948
181regulation of extracellular matrix disassembly (GO:0010715)2.01923759
182axon extension involved in axon guidance (GO:0048846)2.01333915
183neuron projection extension involved in neuron projection guidance (GO:1902284)2.01333915
184barbed-end actin filament capping (GO:0051016)2.01112222

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.88634148
2GBX2_23144817_ChIP-Seq_PC3_Human3.11604045
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.86197115
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.83488668
5DROSHA_22980978_ChIP-Seq_HELA_Human2.75083249
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73603707
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61195141
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61195141
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.53068222
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.50636302
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.48090469
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.46535353
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38567159
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37205294
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.36183776
16* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.35951221
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31602751
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.29673719
19REST_21632747_ChIP-Seq_MESCs_Mouse2.28846148
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.28108640
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.26168623
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.24207257
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.20925971
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.17890354
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06976711
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.06645390
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.95921345
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.93492988
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.79354483
30AR_21572438_ChIP-Seq_LNCaP_Human1.77467447
31CJUN_26792858_Chip-Seq_BT549_Human1.69120268
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67973275
33TP63_17297297_ChIP-ChIP_HaCaT_Human1.66989303
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59641464
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.53181432
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50977209
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.49500283
38SMAD4_21799915_ChIP-Seq_A2780_Human1.47186937
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46110488
40* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45607894
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.44244636
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43506134
43RING1B_27294783_Chip-Seq_ESCs_Mouse1.43142231
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43114756
45BRD4_25478319_ChIP-Seq_HGPS_Human1.41796269
46AR_19668381_ChIP-Seq_PC3_Human1.40331704
47WT1_25993318_ChIP-Seq_PODOCYTE_Human1.40208408
48KDM2B_26808549_Chip-Seq_K562_Human1.39475786
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38616571
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37453706
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.36581885
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35798442
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35653531
54ZNF274_21170338_ChIP-Seq_K562_Hela1.35332653
55CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.35145149
56EP300_21415370_ChIP-Seq_HL-1_Mouse1.35080257
57WT1_19549856_ChIP-ChIP_CCG9911_Human1.34997902
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.33450954
59NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.33450954
60* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33170539
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32510633
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31829388
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.29840356
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28701018
65TP53_18474530_ChIP-ChIP_U2OS_Human1.28013765
66EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.27976277
67TBX20_22328084_ChIP-Seq_HEART_Mouse1.27738772
68TBX20_22080862_ChIP-Seq_HEART_Mouse1.27738772
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26295671
70NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.26186419
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25973870
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25763636
73SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24952981
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.24295404
75DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23259420
76ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23024121
77CLOCK_20551151_ChIP-Seq_293T_Human1.22371983
78TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21975994
79RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21921432
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.21764832
81AHR_22903824_ChIP-Seq_MCF-7_Human1.21321437
82YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20962145
83SMAD_19615063_ChIP-ChIP_OVARY_Human1.20939707
84STAT3_23295773_ChIP-Seq_U87_Human1.20862217
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.17435779
86EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15681279
87ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12544024
88RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12382370
89SMAD3_21741376_ChIP-Seq_HESCs_Human1.12073498
90SMAD4_21741376_ChIP-Seq_HESCs_Human1.10896856
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10538445
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.09229710
93RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08663108
94TP53_16413492_ChIP-PET_HCT116_Human1.07691583
95GATA2_21666600_ChIP-Seq_HMVEC_Human1.07637895
96DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06855849
97TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05950844
98CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05585722
99ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05383602
100VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04871950
101* TP53_23651856_ChIP-Seq_MEFs_Mouse1.04439758
102P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04316667
103OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03814097
104HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03581886
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03175707
106AR_25329375_ChIP-Seq_VCAP_Human1.02967307
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02858566
108TCF4_23295773_ChIP-Seq_U87_Human1.02466727
109NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01564826
110CBX2_27304074_Chip-Seq_ESCs_Mouse1.01553535
111OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00463189
112ISL1_27105846_Chip-Seq_CPCs_Mouse0.99177465
113P300_19829295_ChIP-Seq_ESCs_Human0.99047784
114SMAD3_21741376_ChIP-Seq_ESCs_Human0.98434248
115ESR1_20079471_ChIP-ChIP_T-47D_Human0.97381107
116IGF1R_20145208_ChIP-Seq_DFB_Human0.97056151
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96465511
118TP53_20018659_ChIP-ChIP_R1E_Mouse0.95894623
119NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95735915
120CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95670477
121STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94941147
122BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94793429
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94674716
124CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94138973
125MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94088789
126TET1_21490601_ChIP-Seq_MESCs_Mouse0.93710733
127FOXA2_19822575_ChIP-Seq_HepG2_Human0.93335277
128KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92285865
129PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91203961
130ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90253114
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90211707
132LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89811042
133MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.89767716
134TRIM28_21343339_ChIP-Seq_HEK293_Human0.88905265
135TBX3_20139965_ChIP-Seq_MESCs_Mouse0.88857461
136TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87139857

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.86621696
2MP0008438_abnormal_cutaneous_collagen5.54376785
3MP0005503_abnormal_tendon_morphology3.78981612
4MP0003635_abnormal_synaptic_transmissio3.49175391
5MP0004270_analgesia3.38176639
6MP0005275_abnormal_skin_tensile3.11038617
7MP0003880_abnormal_central_pattern2.93649813
8MP0003705_abnormal_hypodermis_morpholog2.92848651
9MP0002063_abnormal_learning/memory/cond2.79301686
10MP0001958_emphysema2.78374575
11MP0003279_aneurysm2.76389116
12MP0009780_abnormal_chondrocyte_physiolo2.70347366
13MP0005423_abnormal_somatic_nervous2.68654361
14MP0005257_abnormal_intraocular_pressure2.64454723
15MP0009745_abnormal_behavioral_response2.54554722
16MP0009046_muscle_twitch2.34401047
17MP0002064_seizures2.33794942
18MP0001968_abnormal_touch/_nociception2.26851109
19MP0002734_abnormal_mechanical_nocicepti2.20142651
20MP0001486_abnormal_startle_reflex2.17604695
21MP0002572_abnormal_emotion/affect_behav2.13089610
22MP0004858_abnormal_nervous_system1.98976862
23MP0000751_myopathy1.95646443
24MP0009384_cardiac_valve_regurgitation1.95015656
25MP0000778_abnormal_nervous_system1.92551876
26MP0002909_abnormal_adrenal_gland1.90345549
27MP0010368_abnormal_lymphatic_system1.89600563
28MP0003283_abnormal_digestive_organ1.81271842
29MP0003950_abnormal_plasma_membrane1.79866824
30MP0003566_abnormal_cell_adhesion1.77949182
31MP0002822_catalepsy1.77240903
32MP0002272_abnormal_nervous_system1.76917519
33MP0002735_abnormal_chemical_nociception1.76541151
34MP0004215_abnormal_myocardial_fiber1.74727352
35MP0002295_abnormal_pulmonary_circulatio1.72458470
36MP0004811_abnormal_neuron_physiology1.70760462
37MP0002184_abnormal_innervation1.68748175
38MP0003122_maternal_imprinting1.67768810
39MP0002837_dystrophic_cardiac_calcinosis1.66671637
40MP0001440_abnormal_grooming_behavior1.61725762
41MP0000462_abnormal_digestive_system1.61172920
42MP0010386_abnormal_urinary_bladder1.60381809
43MP0008569_lethality_at_weaning1.59245397
44MP0000749_muscle_degeneration1.57438171
45MP0002736_abnormal_nociception_after1.56328183
46MP0000955_abnormal_spinal_cord1.53987868
47MP0003137_abnormal_impulse_conducting1.53205450
48MP0000767_abnormal_smooth_muscle1.52616710
49MP0000569_abnormal_digit_pigmentation1.52613980
50MP0002067_abnormal_sensory_capabilities1.52039074
51MP0002733_abnormal_thermal_nociception1.52004140
52MP0001542_abnormal_bone_strength1.51976103
53MP0004885_abnormal_endolymph1.50739221
54MP0005508_abnormal_skeleton_morphology1.50456885
55MP0003787_abnormal_imprinting1.49808435
56MP0002896_abnormal_bone_mineralization1.49099429
57MP0004233_abnormal_muscle_weight1.48687455
58MP0002557_abnormal_social/conspecific_i1.48416996
59MP0001970_abnormal_pain_threshold1.46666772
60MP0000003_abnormal_adipose_tissue1.43917422
61MP0005386_behavior/neurological_phenoty1.41460545
62MP0004924_abnormal_behavior1.41460545
63MP0003091_abnormal_cell_migration1.40893405
64MP0002882_abnormal_neuron_morphology1.36632657
65MP0010030_abnormal_orbit_morphology1.34868224
66MP0005595_abnormal_vascular_smooth1.34739039
67MP0005623_abnormal_meninges_morphology1.33074257
68MP0001299_abnormal_eye_distance/1.32975935
69MP0004510_myositis1.31226970
70MP0004085_abnormal_heartbeat1.30884213
71MP0004084_abnormal_cardiac_muscle1.27750115
72MP0004145_abnormal_muscle_electrophysio1.26524915
73MP0005551_abnormal_eye_electrophysiolog1.22056190
74MP0005187_abnormal_penis_morphology1.17540904
75MP0001501_abnormal_sleep_pattern1.16829889
76MP0002152_abnormal_brain_morphology1.15961364
77MP0002066_abnormal_motor_capabilities/c1.15934308
78MP0001984_abnormal_olfaction1.14518996
79MP0003329_amyloid_beta_deposits1.14104570
80MP0003633_abnormal_nervous_system1.13822288
81MP0010352_gastrointestinal_tract_polyps1.12939361
82MP0008961_abnormal_basal_metabolism1.11862424
83MP0000759_abnormal_skeletal_muscle1.10982700
84MP0005646_abnormal_pituitary_gland1.10352285
85MP0001502_abnormal_circadian_rhythm1.09018892
86MP0000733_abnormal_muscle_development1.08258130
87MP0002877_abnormal_melanocyte_morpholog1.08088681
88MP0002060_abnormal_skin_morphology1.07434119
89MP0004484_altered_response_of1.06194270
90MP0002127_abnormal_cardiovascular_syste1.05650818
91MP0000747_muscle_weakness1.04934211
92MP0000750_abnormal_muscle_regeneration1.04056352
93MP0000013_abnormal_adipose_tissue1.03531890
94MP0001348_abnormal_lacrimal_gland1.02915730
95MP0009250_abnormal_appendicular_skeleto1.02572725
96MP0005409_darkened_coat_color0.98834475
97MP0003879_abnormal_hair_cell0.98181821
98MP0004134_abnormal_chest_morphology0.96609725
99MP0005023_abnormal_wound_healing0.95517461
100MP0001879_abnormal_lymphatic_vessel0.94882943
101MP0004130_abnormal_muscle_cell0.94031247
102MP0005369_muscle_phenotype0.92181574
103MP0003631_nervous_system_phenotype0.91454060
104MP0003385_abnormal_body_wall0.91119340
105MP0001177_atelectasis0.91113654
106MP0002972_abnormal_cardiac_muscle0.91012308
107MP0006072_abnormal_retinal_apoptosis0.90670565
108MP0005171_absent_coat_pigmentation0.90649064
109MP0005620_abnormal_muscle_contractility0.90531991
110MP0002234_abnormal_pharynx_morphology0.90408214
111MP0002090_abnormal_vision0.88070745
112MP0000428_abnormal_craniofacial_morphol0.87555547
113MP0000631_abnormal_neuroendocrine_gland0.86495116
114MP0004087_abnormal_muscle_fiber0.86046491
115MP0003861_abnormal_nervous_system0.85095234
116MP0003634_abnormal_glial_cell0.84837432
117MP0005248_abnormal_Harderian_gland0.84385381
118MP0000163_abnormal_cartilage_morphology0.84126787
119MP0000534_abnormal_ureter_morphology0.82991047
120MP0003942_abnormal_urinary_system0.81902737
121MP0004036_abnormal_muscle_relaxation0.80955080
122MP0002653_abnormal_ependyma_morphology0.80483916
123MP0002069_abnormal_eating/drinking_beha0.78859859
124MP0002269_muscular_atrophy0.78582940
125MP0006054_spinal_hemorrhage0.77445359
126MP0002752_abnormal_somatic_nervous0.77137124
127MP0005253_abnormal_eye_physiology0.76422391
128MP0002168_other_aberrant_phenotype0.76077253
129MP0000538_abnormal_urinary_bladder0.75887180
130MP0006276_abnormal_autonomic_nervous0.75304285
131MP0005375_adipose_tissue_phenotype0.73883524
132MP0003121_genomic_imprinting0.73386430
133MP0003045_fibrosis0.73298966
134MP0000920_abnormal_myelination0.73282483
135MP0003119_abnormal_digestive_system0.72994920
136MP0002106_abnormal_muscle_physiology0.72531485
137MP0002128_abnormal_blood_circulation0.72359558
138MP0002229_neurodegeneration0.71950404
139MP0006138_congestive_heart_failure0.70292194
140MP0005197_abnormal_uvea_morphology0.70269147
141MP0003646_muscle_fatigue0.69983331
142MP0004272_abnormal_basement_membrane0.68945521
143MP0005670_abnormal_white_adipose0.68693434
144MP0002108_abnormal_muscle_morphology0.68088484
145MP0004142_abnormal_muscle_tone0.67399439
146MP0003123_paternal_imprinting0.67021343
147MP0003632_abnormal_nervous_system0.66978162
148MP0005330_cardiomyopathy0.66232903
149MP0005499_abnormal_olfactory_system0.65822160
150MP0005394_taste/olfaction_phenotype0.65822160
151MP0003690_abnormal_glial_cell0.65640655
152MP0002089_abnormal_postnatal_growth/wei0.63036816
153MP0008775_abnormal_heart_ventricle0.62290513
154MP0001485_abnormal_pinna_reflex0.62244858

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.26725715
2Protrusio acetabuli (HP:0003179)5.22240807
3Focal motor seizures (HP:0011153)5.16150579
4Myokymia (HP:0002411)5.02145871
5Aortic aneurysm (HP:0004942)4.19205436
6Focal seizures (HP:0007359)4.17677287
7Visual hallucinations (HP:0002367)3.84621272
8Vascular tortuosity (HP:0004948)3.77228505
9Type 1 muscle fiber predominance (HP:0003803)3.75165860
10Epileptic encephalopathy (HP:0200134)3.74287732
11Aortic dissection (HP:0002647)3.73528962
12Progressive cerebellar ataxia (HP:0002073)3.61762796
13Spinal rigidity (HP:0003306)3.52769881
14Action tremor (HP:0002345)3.42226955
15Slender build (HP:0001533)3.35185186
16Arterial tortuosity (HP:0005116)3.32856544
17Genetic anticipation (HP:0003743)3.22811112
18Ankle contracture (HP:0006466)3.16375360
19Bladder diverticulum (HP:0000015)3.10950627
20Broad-based gait (HP:0002136)3.04279734
21Febrile seizures (HP:0002373)2.99549946
22Soft skin (HP:0000977)2.97055260
23Follicular hyperkeratosis (HP:0007502)2.96428187
24Increased variability in muscle fiber diameter (HP:0003557)2.90358432
25Wormian bones (HP:0002645)2.88125363
26Atrophic scars (HP:0001075)2.81368402
27Absence seizures (HP:0002121)2.79909175
28Depression (HP:0000716)2.74712587
29Dysdiadochokinesis (HP:0002075)2.74172739
30Mildly elevated creatine phosphokinase (HP:0008180)2.70666541
31Generalized tonic-clonic seizures (HP:0002069)2.70544311
32Ventricular fibrillation (HP:0001663)2.70156956
33Ankle clonus (HP:0011448)2.70156865
34Supranuclear gaze palsy (HP:0000605)2.69263210
35Atonic seizures (HP:0010819)2.63811642
36Mutism (HP:0002300)2.63360818
37Fragile skin (HP:0001030)2.59352484
38Prolonged QT interval (HP:0001657)2.57907301
39Sudden death (HP:0001699)2.56594697
40Hepatoblastoma (HP:0002884)2.56594014
41Urinary bladder sphincter dysfunction (HP:0002839)2.55623302
42Abnormality of dentin (HP:0010299)2.55456024
43Excessive salivation (HP:0003781)2.52842484
44Drooling (HP:0002307)2.52842484
45Hyperventilation (HP:0002883)2.52392587
46Cerebral aneurysm (HP:0004944)2.50213811
47Dysmetric saccades (HP:0000641)2.45880140
48Hyporeflexia of lower limbs (HP:0002600)2.45376183
49Papilledema (HP:0001085)2.44780727
50Hyperextensible skin (HP:0000974)2.42688882
51Truncal ataxia (HP:0002078)2.42431008
52Poor eye contact (HP:0000817)2.40246970
53Impaired vibration sensation in the lower limbs (HP:0002166)2.40047196
54Bowel diverticulosis (HP:0005222)2.39938747
55Cervical subluxation (HP:0003308)2.39830123
56Dialeptic seizures (HP:0011146)2.39504895
57Megalencephaly (HP:0001355)2.35943273
58Abnormality of skeletal muscle fiber size (HP:0012084)2.35433128
59Shallow orbits (HP:0000586)2.33750338
60Genu recurvatum (HP:0002816)2.33536107
61Postural instability (HP:0002172)2.33224401
62Gaze-evoked nystagmus (HP:0000640)2.32401876
63Hemiplegia (HP:0002301)2.30819920
64Impaired social interactions (HP:0000735)2.30687751
65Abnormal social behavior (HP:0012433)2.30687751
66Abnormality of the lower motor neuron (HP:0002366)2.30279364
67Abnormal EKG (HP:0003115)2.29946441
68Obstructive sleep apnea (HP:0002870)2.29739699
69Mitral stenosis (HP:0001718)2.29410370
70Biconcave vertebral bodies (HP:0004586)2.29104030
71Neonatal short-limb short stature (HP:0008921)2.27939934
72Macroorchidism (HP:0000053)2.27693941
73Aortic regurgitation (HP:0001659)2.26594473
74Increased connective tissue (HP:0009025)2.25851273
75Primary atrial arrhythmia (HP:0001692)2.23917584
76Anxiety (HP:0000739)2.22295786
77Mitral regurgitation (HP:0001653)2.22269129
78Long toe (HP:0010511)2.21202267
79Lower limb amyotrophy (HP:0007210)2.21043500
80Atrial fibrillation (HP:0005110)2.20990483
81Aqueductal stenosis (HP:0002410)2.20868148
82Vertebral compression fractures (HP:0002953)2.20369569
83Aneurysm (HP:0002617)2.19968143
84Urinary urgency (HP:0000012)2.12771578
85Hemiparesis (HP:0001269)2.12644331
86Joint laxity (HP:0001388)2.11622752
87Bundle branch block (HP:0011710)2.11513551
88Torticollis (HP:0000473)2.10758200
89Hypoplasia of the iris (HP:0007676)2.10598374
90Pointed chin (HP:0000307)2.10511830
91Abnormality of the right ventricle (HP:0001707)2.10229043
92Cardiovascular calcification (HP:0011915)2.08885981
93Dysmetria (HP:0001310)2.08818744
94Impaired smooth pursuit (HP:0007772)2.08500285
95Dilatation of the ascending aorta (HP:0005111)2.08282601
96Asymmetric septal hypertrophy (HP:0001670)2.08036543
97Supraventricular tachycardia (HP:0004755)2.06172499
98Syncope (HP:0001279)2.06171996
99Mild short stature (HP:0003502)2.05198125
100Supraventricular arrhythmia (HP:0005115)2.04713115
101Agitation (HP:0000713)2.04126670
102Mitral valve prolapse (HP:0001634)2.03668232
103Pheochromocytoma (HP:0002666)2.02916958
104Central scotoma (HP:0000603)2.02679965
105Bradycardia (HP:0001662)2.02599145
106Abnormal eating behavior (HP:0100738)1.99808757
107Stereotypic behavior (HP:0000733)1.96540292
108Termporal pattern (HP:0011008)1.96453662
109Insidious onset (HP:0003587)1.96453662
110Epileptiform EEG discharges (HP:0011182)1.96434152
111Round ear (HP:0100830)1.96294927
112Aplasia involving bones of the extremities (HP:0009825)1.96174567
113Aplasia involving bones of the upper limbs (HP:0009823)1.96174567
114Aplasia of the phalanges of the hand (HP:0009802)1.96174567
115Blue sclerae (HP:0000592)1.94825540
116Abnormal atrioventricular conduction (HP:0005150)1.93531525
117EEG with generalized epileptiform discharges (HP:0011198)1.91989562
118Annular pancreas (HP:0001734)1.91972394
119Absent speech (HP:0001344)1.91735779
120Limb-girdle muscle weakness (HP:0003325)1.90987588
121Hypsarrhythmia (HP:0002521)1.89554484
122Wide anterior fontanel (HP:0000260)1.87200907
123Abnormality of the anterior chamber (HP:0000593)1.86962466
124Insomnia (HP:0100785)1.85753391
125Abnormality of binocular vision (HP:0011514)1.85389557
126Diplopia (HP:0000651)1.85389557
127Spondylolisthesis (HP:0003302)1.84169575
128Wrist flexion contracture (HP:0001239)1.84074770
129Muscle fiber splitting (HP:0003555)1.83983224
130Congenital glaucoma (HP:0001087)1.83481907
131Abnormality of ocular smooth pursuit (HP:0000617)1.82738639
132Osteolytic defects of the hand bones (HP:0009699)1.82055603
133Osteolytic defects of the phalanges of the hand (HP:0009771)1.82055603
134Spastic gait (HP:0002064)1.81282706
135Asymmetry of the thorax (HP:0001555)1.79803541
136Neoplasm of the heart (HP:0100544)1.79482917
137Short 4th metacarpal (HP:0010044)1.78922225
138Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.78922225
139Vertebral arch anomaly (HP:0008438)1.76744669
140Ovoid vertebral bodies (HP:0003300)1.76701983
141Aortic valve stenosis (HP:0001650)1.76551641
142Focal dystonia (HP:0004373)1.75667231
143Lower limb muscle weakness (HP:0007340)1.74576674
144Distal lower limb amyotrophy (HP:0008944)1.74331392
145Distal lower limb muscle weakness (HP:0009053)1.74251499
146Pulmonic stenosis (HP:0001642)1.74235844
147Ankyloglossia (HP:0010296)1.74093552
148Overgrowth (HP:0001548)1.73854751
149Broad metatarsal (HP:0001783)1.73648201
150Elbow flexion contracture (HP:0002987)1.73001652
151Joint stiffness (HP:0001387)1.72748482
152Intention tremor (HP:0002080)1.71927423
153Heart block (HP:0012722)1.71536418
154Natal tooth (HP:0000695)1.69523817
155Ventricular tachycardia (HP:0004756)1.68930039
156Hypoventilation (HP:0002791)1.68877260
157Amyotrophic lateral sclerosis (HP:0007354)1.68617340
158Amblyopia (HP:0000646)1.68503015
159Buphthalmos (HP:0000557)1.68258458
160Short nail (HP:0001799)1.67900461
161Abnormality of the corticospinal tract (HP:0002492)1.67514614
162Exercise-induced myalgia (HP:0003738)1.67214211
163Scotoma (HP:0000575)1.67036355
164J-shaped sella turcica (HP:0002680)1.66965533
165Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.66699979
166Bradykinesia (HP:0002067)1.66118471
167Hallux valgus (HP:0001822)1.63747027
168Elfin facies (HP:0004428)1.63474551
169Open mouth (HP:0000194)1.63231407
170Advanced eruption of teeth (HP:0006288)1.62658668
171Abnormality of the calf musculature (HP:0001430)1.61938368
172Neuroendocrine neoplasm (HP:0100634)1.61879235
173Inappropriate behavior (HP:0000719)1.61821449
174Cutaneous finger syndactyly (HP:0010554)1.61718914
175Hyperacusis (HP:0010780)1.61659528
176Knee flexion contracture (HP:0006380)1.61433206
177Scanning speech (HP:0002168)1.60097567
178Deviation of the hallux (HP:0010051)1.59173195
179Pulmonary artery stenosis (HP:0004415)1.58658897
180Limited hip movement (HP:0008800)1.56373937
181Mucopolysacchariduria (HP:0008155)1.55419656
182Urinary glycosaminoglycan excretion (HP:0003541)1.55419656
183Lymphangioma (HP:0100764)1.53294477

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.36076983
2MYLK3.82185775
3NTRK33.62872621
4EPHA43.33455459
5MAP3K92.98861346
6PRKD32.58109064
7TRPM72.55738534
8MINK12.43311853
9PHKG12.38490897
10PHKG22.38490897
11AKT32.30581843
12NTRK22.25099510
13MAP3K42.23778493
14DAPK22.15372190
15PAK62.14005988
16CAMKK12.11611128
17LMTK22.00188394
18CASK1.97207712
19NTRK11.93620052
20TESK11.85160306
21LIMK11.77831356
22LATS21.62119529
23NEK91.59861169
24KSR11.51749009
25SIK21.50399896
26TGFBR21.47418073
27MAPK131.42621055
28RIPK11.41471691
29BMPR1B1.41034913
30CDK51.36845928
31STK381.35034869
32KSR21.33793503
33MAP2K71.29641462
34PAK21.28721256
35ROCK21.28560200
36ERN11.26276612
37PRKD21.23996092
38MAP2K41.23748102
39PAK31.17807639
40LATS11.14987371
41EEF2K1.14242544
42NEK11.09160590
43TIE11.08457375
44TRIB31.08447838
45PRPF4B1.07855015
46DMPK1.06737379
47CAMK1G1.05638339
48PRKCH1.04827735
49TYRO31.04039712
50PRKCG1.03061835
51PDGFRA1.01233054
52CAMKK21.00889830
53CDC42BPA1.00886843
54UHMK10.99050974
55RET0.98215593
56CAMK10.97155469
57CAMK2G0.94882466
58PKN20.94703424
59EPHB10.94396081
60MARK20.93305739
61DAPK10.92049351
62INSRR0.90850699
63PLK20.90453342
64SGK30.89030877
65FRK0.88010550
66TNIK0.87658542
67MAPKAPK30.87567761
68TAOK10.87203931
69MTOR0.86012308
70MET0.84983983
71STK110.84487713
72SGK4940.84344277
73SGK2230.84344277
74EPHB20.81703180
75CAMK2A0.80933809
76HIPK20.78750550
77FGFR20.77718766
78CDK180.76641000
79CDK150.76466983
80SGK20.76444041
81ALK0.75877220
82CDK140.75238785
83MAPK70.73034426
84CAMK40.72018288
85MAP3K60.71733961
86DYRK1A0.71332137
87DDR20.71267686
88PIK3CA0.70749135
89SGK10.68318776
90ILK0.67688536
91PRKCZ0.65349420
92MAP3K20.65001998
93CDK11A0.64830029
94PIK3CG0.64142037
95ICK0.64094451
96ADRBK10.62874274
97PTK2B0.62289325
98CAMK1D0.61544994
99WNK10.61380968
100MAP3K70.61032718
101PRKCE0.59364233
102MUSK0.59250467
103CSNK1G20.58573097
104FGFR30.57253724
105FER0.57019372
106GRK50.56333433
107RPS6KA30.55623523
108OBSCN0.54345109
109PINK10.54250695
110MOS0.54245892
111ROCK10.54089638
112ERBB30.53442504
113FES0.53420931
114MAPK120.53288155
115PRKG20.52854299
116PAK40.52146072
117GRK10.51221579
118RPS6KA20.51174874
119FYN0.50606077
120MAP2K10.50438821
121PDK30.47839719
122PDK40.47839719
123STK38L0.47769170
124SIK10.47730005
125FGFR10.47448425
126GSK3A0.47422414
127DAPK30.47039390
128MAPK100.46216873
129CAMK2B0.46212724
130STK30.46013704
131PRKD10.45691986
132AKT20.45191532
133SCYL20.44923659
134IRAK10.44181682
135CAMK2D0.43991283
136PTK20.43777378
137PDK10.43586497
138ABL20.43491384
139ERBB20.43444157
140DYRK20.41254643
141TTN0.40674752
142PDPK10.40674576
143PRKAA10.40478685
144PDGFRB0.40062493

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.73376887
2ECM-receptor interaction_Homo sapiens_hsa045122.54781808
3Circadian entrainment_Homo sapiens_hsa047132.51360532
4Synaptic vesicle cycle_Homo sapiens_hsa047212.44377146
5GABAergic synapse_Homo sapiens_hsa047272.38121622
6Olfactory transduction_Homo sapiens_hsa047402.29334699
7Glutamatergic synapse_Homo sapiens_hsa047242.22008801
8Morphine addiction_Homo sapiens_hsa050322.18348001
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.17473464
10Long-term potentiation_Homo sapiens_hsa047202.15849278
11Insulin secretion_Homo sapiens_hsa049112.13151296
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.12370285
13Amphetamine addiction_Homo sapiens_hsa050312.00790488
14Dopaminergic synapse_Homo sapiens_hsa047281.97471339
15Cholinergic synapse_Homo sapiens_hsa047251.93472110
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.93198228
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.84371154
18Salivary secretion_Homo sapiens_hsa049701.84206698
19Gastric acid secretion_Homo sapiens_hsa049711.74967407
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.68560588
21Cocaine addiction_Homo sapiens_hsa050301.58856229
22Oxytocin signaling pathway_Homo sapiens_hsa049211.54937577
23Dilated cardiomyopathy_Homo sapiens_hsa054141.53436785
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.52890174
25Renin secretion_Homo sapiens_hsa049241.51573832
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.48234562
27Type II diabetes mellitus_Homo sapiens_hsa049301.47070616
28Calcium signaling pathway_Homo sapiens_hsa040201.41338034
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41271099
30Taste transduction_Homo sapiens_hsa047421.40947646
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.39327267
32Axon guidance_Homo sapiens_hsa043601.37575675
33Long-term depression_Homo sapiens_hsa047301.36146971
34Phototransduction_Homo sapiens_hsa047441.35434989
35Gap junction_Homo sapiens_hsa045401.35393279
36GnRH signaling pathway_Homo sapiens_hsa049121.31878533
37cAMP signaling pathway_Homo sapiens_hsa040241.29012251
38Estrogen signaling pathway_Homo sapiens_hsa049151.27704350
39Glioma_Homo sapiens_hsa052141.24374944
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.24232227
41Serotonergic synapse_Homo sapiens_hsa047261.23364662
42Melanogenesis_Homo sapiens_hsa049161.16406776
43Protein digestion and absorption_Homo sapiens_hsa049741.14391910
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14221127
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.13296348
46Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.10704861
47Melanoma_Homo sapiens_hsa052181.10394581
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06528573
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05250071
50ErbB signaling pathway_Homo sapiens_hsa040121.04836926
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03999490
52Cardiac muscle contraction_Homo sapiens_hsa042601.03998039
53Prion diseases_Homo sapiens_hsa050201.00094230
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99657577
55TGF-beta signaling pathway_Homo sapiens_hsa043500.98430503
56Dorso-ventral axis formation_Homo sapiens_hsa043200.98284475
57Adherens junction_Homo sapiens_hsa045200.98114045
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96310039
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93854148
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.93469124
61Nitrogen metabolism_Homo sapiens_hsa009100.92041965
62Glucagon signaling pathway_Homo sapiens_hsa049220.88475392
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.86363382
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84313918
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83549309
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83177947
67mTOR signaling pathway_Homo sapiens_hsa041500.83123327
68Endometrial cancer_Homo sapiens_hsa052130.82901034
69PI3K-Akt signaling pathway_Homo sapiens_hsa041510.82230584
70Thyroid hormone synthesis_Homo sapiens_hsa049180.81504886
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79475583
72Sphingolipid metabolism_Homo sapiens_hsa006000.78552953
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.77902806
74Pancreatic secretion_Homo sapiens_hsa049720.76483273
75Oocyte meiosis_Homo sapiens_hsa041140.76101796
76Rap1 signaling pathway_Homo sapiens_hsa040150.75854395
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74761162
78MicroRNAs in cancer_Homo sapiens_hsa052060.73905476
79MAPK signaling pathway_Homo sapiens_hsa040100.72666094
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72393696
81Small cell lung cancer_Homo sapiens_hsa052220.71959206
82Insulin signaling pathway_Homo sapiens_hsa049100.71101459
83Wnt signaling pathway_Homo sapiens_hsa043100.68237108
84Ras signaling pathway_Homo sapiens_hsa040140.66462615
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66353860
86Vibrio cholerae infection_Homo sapiens_hsa051100.65191376
87Complement and coagulation cascades_Homo sapiens_hsa046100.65054955
88Renal cell carcinoma_Homo sapiens_hsa052110.63813270
89VEGF signaling pathway_Homo sapiens_hsa043700.62699027
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62064446
91Prostate cancer_Homo sapiens_hsa052150.61011915
92Hippo signaling pathway_Homo sapiens_hsa043900.60692067
93Choline metabolism in cancer_Homo sapiens_hsa052310.59675830
94Focal adhesion_Homo sapiens_hsa045100.58085799
95Hedgehog signaling pathway_Homo sapiens_hsa043400.58039331
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57349586
97Tight junction_Homo sapiens_hsa045300.57187733
98Pathways in cancer_Homo sapiens_hsa052000.57057473
99Bladder cancer_Homo sapiens_hsa052190.55773101
100Circadian rhythm_Homo sapiens_hsa047100.55490444
101Colorectal cancer_Homo sapiens_hsa052100.55285071
102Chronic myeloid leukemia_Homo sapiens_hsa052200.54482362
103Endocytosis_Homo sapiens_hsa041440.54281114
104Ovarian steroidogenesis_Homo sapiens_hsa049130.53576520
105Non-small cell lung cancer_Homo sapiens_hsa052230.53509257
106Bile secretion_Homo sapiens_hsa049760.53032096
107Alcoholism_Homo sapiens_hsa050340.52956691
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50994582
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.50960055
110Basal cell carcinoma_Homo sapiens_hsa052170.50482049
111Proteoglycans in cancer_Homo sapiens_hsa052050.49969412
112AMPK signaling pathway_Homo sapiens_hsa041520.49541315
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.46489170
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46123458
115Insulin resistance_Homo sapiens_hsa049310.45670980
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41694039
117Inositol phosphate metabolism_Homo sapiens_hsa005620.41684463
118Collecting duct acid secretion_Homo sapiens_hsa049660.40438614
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38475966
120Amoebiasis_Homo sapiens_hsa051460.36614127

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