PCDHGA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.11516912
2locomotory exploration behavior (GO:0035641)4.75499937
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.28595492
4synaptic vesicle maturation (GO:0016188)4.20699764
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.08672626
6fucose catabolic process (GO:0019317)4.07695390
7L-fucose metabolic process (GO:0042354)4.07695390
8L-fucose catabolic process (GO:0042355)4.07695390
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.84971214
10vocalization behavior (GO:0071625)3.76730456
11indolalkylamine metabolic process (GO:0006586)3.70076943
12nephron tubule morphogenesis (GO:0072078)3.65807763
13nephron epithelium morphogenesis (GO:0072088)3.65807763
14cellular ketone body metabolic process (GO:0046950)3.55584044
15detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.52193001
16regulation of synaptic vesicle exocytosis (GO:2000300)3.49493080
17cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.48265403
18indole-containing compound metabolic process (GO:0042430)3.44586644
19primary amino compound metabolic process (GO:1901160)3.44139559
20dendrite morphogenesis (GO:0048813)3.43123753
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.41815573
22regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.40082517
23cell communication by electrical coupling (GO:0010644)3.37671604
24glutamate secretion (GO:0014047)3.37332841
25kynurenine metabolic process (GO:0070189)3.36880897
26synaptic vesicle docking involved in exocytosis (GO:0016081)3.36463154
27G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.35922123
28synaptic vesicle exocytosis (GO:0016079)3.35394472
29exploration behavior (GO:0035640)3.34502277
30detection of light stimulus involved in sensory perception (GO:0050962)3.34275148
31detection of light stimulus involved in visual perception (GO:0050908)3.34275148
32serotonin metabolic process (GO:0042428)3.32048065
33indole-containing compound catabolic process (GO:0042436)3.31344936
34indolalkylamine catabolic process (GO:0046218)3.31344936
35tryptophan catabolic process (GO:0006569)3.31344936
36neuronal action potential (GO:0019228)3.29393751
37postsynaptic membrane organization (GO:0001941)3.25883445
38tryptophan metabolic process (GO:0006568)3.25335864
39epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.20143233
40DNA deamination (GO:0045006)3.19318014
41regulation of synapse structural plasticity (GO:0051823)3.18691417
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.16735159
43renal tubule morphogenesis (GO:0061333)3.15474936
44axoneme assembly (GO:0035082)3.15049203
45neuron cell-cell adhesion (GO:0007158)3.15005257
46regulation of glutamate receptor signaling pathway (GO:1900449)3.13136246
47neurotransmitter-gated ion channel clustering (GO:0072578)3.11456629
48ketone body metabolic process (GO:1902224)3.10831243
49water-soluble vitamin biosynthetic process (GO:0042364)3.05109229
50activation of protein kinase A activity (GO:0034199)3.05029115
51regulation of synaptic vesicle transport (GO:1902803)3.04578310
52layer formation in cerebral cortex (GO:0021819)3.02403271
53regulation of neuronal synaptic plasticity (GO:0048168)3.01567951
54ionotropic glutamate receptor signaling pathway (GO:0035235)2.98887168
55auditory behavior (GO:0031223)2.98070268
56platelet dense granule organization (GO:0060155)2.95791183
57innervation (GO:0060384)2.95771632
58protein localization to synapse (GO:0035418)2.95607003
59mannosylation (GO:0097502)2.94961034
60L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.92991198
61cAMP catabolic process (GO:0006198)2.92379881
62synaptic transmission, glutamatergic (GO:0035249)2.91944315
63response to auditory stimulus (GO:0010996)2.91870759
64proline transport (GO:0015824)2.91464674
65C4-dicarboxylate transport (GO:0015740)2.90357856
66epithelial cilium movement (GO:0003351)2.89689820
67neurotransmitter secretion (GO:0007269)2.88909795
68regulation of long-term neuronal synaptic plasticity (GO:0048169)2.88613973
69positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.87657271
70ubiquinone biosynthetic process (GO:0006744)2.86283527
71axonal fasciculation (GO:0007413)2.85940000
72behavioral response to ethanol (GO:0048149)2.85860781
73cellular potassium ion homeostasis (GO:0030007)2.85294069
74retinal cone cell development (GO:0046549)2.82928033
75regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.82736394
76positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.82423160
77negative regulation of mast cell activation (GO:0033004)2.80737106
78detection of calcium ion (GO:0005513)2.80082914
79regulation of cilium movement (GO:0003352)2.77369456
80parturition (GO:0007567)2.77270985
81regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.76778200
82mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.76525389
83mitochondrial respiratory chain complex I assembly (GO:0032981)2.76525389
84NADH dehydrogenase complex assembly (GO:0010257)2.76525389
85regulation of action potential (GO:0098900)2.75707330
86protein complex biogenesis (GO:0070271)2.74287170
87sulfation (GO:0051923)2.74145863
88gamma-aminobutyric acid transport (GO:0015812)2.73945437
89glutamate receptor signaling pathway (GO:0007215)2.73669563
90cyclic nucleotide catabolic process (GO:0009214)2.73193366
91dendritic spine morphogenesis (GO:0060997)2.72891846
92sodium ion export (GO:0071436)2.72871190
93chemosensory behavior (GO:0007635)2.72618533
94auditory receptor cell differentiation (GO:0042491)2.71627092
95spinal cord motor neuron differentiation (GO:0021522)2.71556715
96negative regulation of catenin import into nucleus (GO:0035414)2.70631979
97L-methionine salvage (GO:0071267)2.70550383
98L-methionine biosynthetic process (GO:0071265)2.70550383
99amino acid salvage (GO:0043102)2.70550383
100regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.69453160
101long-term memory (GO:0007616)2.69059414
102positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.69036384
103photoreceptor cell development (GO:0042461)2.68949292
104piRNA metabolic process (GO:0034587)2.66990071
105preassembly of GPI anchor in ER membrane (GO:0016254)2.66858541
106positive regulation of sodium ion transmembrane transport (GO:1902307)2.63239421
107respiratory chain complex IV assembly (GO:0008535)2.63136514
108cell communication involved in cardiac conduction (GO:0086065)2.63010942
109amino acid import (GO:0043090)2.61499451
110neuron recognition (GO:0008038)2.61372209
111reflex (GO:0060004)2.61281040
112cerebellar Purkinje cell differentiation (GO:0021702)2.61142537
113presynaptic membrane assembly (GO:0097105)2.61128485
114positive regulation of synaptic transmission, GABAergic (GO:0032230)2.60976617
115action potential (GO:0001508)2.59496180
116polyol catabolic process (GO:0046174)2.59452551
117insulin-like growth factor receptor signaling pathway (GO:0048009)2.59298165
118ubiquinone metabolic process (GO:0006743)2.58096441
119central nervous system projection neuron axonogenesis (GO:0021952)2.57948660
120head development (GO:0060322)2.57770233
121nonmotile primary cilium assembly (GO:0035058)2.57447524
122regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.56395926
123positive regulation of membrane potential (GO:0045838)2.55077844
124response to pheromone (GO:0019236)2.54129433
125drug catabolic process (GO:0042737)2.53783659
126phosphatidylinositol acyl-chain remodeling (GO:0036149)2.53506872
127neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.53429861
128appendage development (GO:0048736)2.53339182
129limb development (GO:0060173)2.53339182
130regulation of axon guidance (GO:1902667)2.52647028
131membrane hyperpolarization (GO:0060081)2.51681590
132atrial cardiac muscle cell action potential (GO:0086014)2.51350464
133regulation of dendritic spine morphogenesis (GO:0061001)2.51195900
134neuron-neuron synaptic transmission (GO:0007270)2.50968453
135negative regulation of synaptic transmission, GABAergic (GO:0032229)2.50680517
136regulation of excitatory postsynaptic membrane potential (GO:0060079)2.50448485
137establishment of nucleus localization (GO:0040023)2.50251957
138long-term synaptic potentiation (GO:0060291)2.49563427
139transmission of nerve impulse (GO:0019226)2.47800661
140rRNA catabolic process (GO:0016075)2.47555833
141suckling behavior (GO:0001967)2.47470193
142oxidative demethylation (GO:0070989)2.47437184
143dopamine transport (GO:0015872)2.45860884
144mitochondrial respiratory chain complex assembly (GO:0033108)2.45788255
145potassium ion import (GO:0010107)2.44976344
146negative regulation of cytosolic calcium ion concentration (GO:0051481)2.43798047
147regulation of postsynaptic membrane potential (GO:0060078)2.43416428
148cerebellar Purkinje cell layer development (GO:0021680)2.43407263
149vesicle transport along microtubule (GO:0047496)2.42930890
150regulation of synaptic transmission, glutamatergic (GO:0051966)2.42884443
151L-amino acid import (GO:0043092)2.41636755
152membrane depolarization during action potential (GO:0086010)2.40897086
153cilium organization (GO:0044782)2.40594264
154quinone biosynthetic process (GO:1901663)2.39692578
155protein localization to cilium (GO:0061512)2.39156905
156insulin secretion (GO:0030073)2.38692355
157* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.38367153
158alanine transport (GO:0032328)2.37846068
159regulation of neurotransmitter uptake (GO:0051580)2.37765137
160positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.37655455
161regulation of synaptic plasticity (GO:0048167)2.35399849
162purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.35271681
1633-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.35271681
164cornea development in camera-type eye (GO:0061303)2.35252550
165positive regulation of action potential (GO:0045760)2.35094593
166neuron fate determination (GO:0048664)2.34873734
167regulation of axon extension involved in axon guidance (GO:0048841)2.34868392
168cerebellar granule cell differentiation (GO:0021707)2.34552376
169startle response (GO:0001964)2.34527264
170inositol phosphate catabolic process (GO:0071545)2.34344090
171cilium assembly (GO:0042384)2.32881849
172S-adenosylmethionine metabolic process (GO:0046500)2.32604210
173neuromuscular process controlling balance (GO:0050885)2.32116078
174negative regulation of vascular permeability (GO:0043116)2.32102473
175cytochrome complex assembly (GO:0017004)2.32092936
176regulation of neurotransmitter secretion (GO:0046928)2.31968329
177neuronal action potential propagation (GO:0019227)2.31765966
178neuronal ion channel clustering (GO:0045161)2.31689553
179cilium movement (GO:0003341)2.30860969
180eye photoreceptor cell development (GO:0042462)2.30785300
181positive regulation of potassium ion transmembrane transport (GO:1901381)2.30023001
182cerebellum development (GO:0021549)2.29682773
183positive regulation of synapse maturation (GO:0090129)2.29282514
184glycerophospholipid catabolic process (GO:0046475)2.29227371
185cAMP-mediated signaling (GO:0019933)2.29060138
186protein targeting to plasma membrane (GO:0072661)2.28915712
187positive regulation of axon extension (GO:0045773)2.28790156
188synapse assembly (GO:0007416)2.28558011
189synaptic vesicle endocytosis (GO:0048488)2.28288924
190neuromuscular synaptic transmission (GO:0007274)2.27760424
191urinary tract smooth muscle contraction (GO:0014848)2.27562996
192regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.27215194

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.90772863
2VDR_22108803_ChIP-Seq_LS180_Human3.28909271
3GBX2_23144817_ChIP-Seq_PC3_Human3.22928091
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.88370169
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69223415
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.60367917
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.33207288
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.30226146
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.30226146
10* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.28970787
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27464856
12DROSHA_22980978_ChIP-Seq_HELA_Human2.21712277
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.19281628
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.18577736
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.16060438
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.13676258
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.12867323
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.12015120
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.10550017
20AR_21572438_ChIP-Seq_LNCaP_Human2.02519859
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.94920292
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91024035
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.89418577
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.87002212
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81693437
26IGF1R_20145208_ChIP-Seq_DFB_Human1.81518117
27REST_21632747_ChIP-Seq_MESCs_Mouse1.79686086
28FUS_26573619_Chip-Seq_HEK293_Human1.77594006
29RARB_27405468_Chip-Seq_BRAIN_Mouse1.75655780
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73026710
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72944401
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.69000562
33ER_23166858_ChIP-Seq_MCF-7_Human1.68587302
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65377872
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64964083
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.64758228
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63466033
38ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.63076980
39EWS_26573619_Chip-Seq_HEK293_Human1.62145869
40TAF15_26573619_Chip-Seq_HEK293_Human1.61008470
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58554618
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56864682
43SMAD4_21799915_ChIP-Seq_A2780_Human1.56761436
44CBP_20019798_ChIP-Seq_JUKART_Human1.54235479
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54235479
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49643328
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.49392145
48EP300_21415370_ChIP-Seq_HL-1_Mouse1.49199577
49EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47309589
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.46794434
51TP53_16413492_ChIP-PET_HCT116_Human1.45682508
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.45290861
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44580938
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43452914
55TP53_22573176_ChIP-Seq_HFKS_Human1.42343036
56ZNF274_21170338_ChIP-Seq_K562_Hela1.40960490
57* REST_18959480_ChIP-ChIP_MESCs_Mouse1.40623407
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39305172
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39211789
60SOX2_21211035_ChIP-Seq_LN229_Gbm1.39030567
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.37166113
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36637398
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35005768
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34683349
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33754012
66YAP1_20516196_ChIP-Seq_MESCs_Mouse1.31887619
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30359825
68AR_19668381_ChIP-Seq_PC3_Human1.29793727
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29321963
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27798609
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27736070
72EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.27241694
73EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27081361
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26786922
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26372171
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26372171
77TCF4_22108803_ChIP-Seq_LS180_Human1.25940873
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.25870515
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24946939
80AHR_22903824_ChIP-Seq_MCF-7_Human1.24841583
81STAT3_23295773_ChIP-Seq_U87_Human1.24218440
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23596193
83ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23565306
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22698899
85AR_25329375_ChIP-Seq_VCAP_Human1.21452111
86FOXA1_25329375_ChIP-Seq_VCAP_Human1.21348764
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21348764
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21262546
89TRIM28_21343339_ChIP-Seq_HEK293_Human1.20751239
90CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20654274
91GATA3_21878914_ChIP-Seq_MCF-7_Human1.20182820
92NANOG_19829295_ChIP-Seq_ESCs_Human1.19320458
93SOX2_19829295_ChIP-Seq_ESCs_Human1.19320458
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18235142
95RING1B_27294783_Chip-Seq_ESCs_Mouse1.17382176
96P300_19829295_ChIP-Seq_ESCs_Human1.17239362
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16169127
98RXR_22108803_ChIP-Seq_LS180_Human1.15928588
99SMAD4_21741376_ChIP-Seq_EPCs_Human1.15763460
100NFE2_27457419_Chip-Seq_LIVER_Mouse1.14978205
101SMAD3_21741376_ChIP-Seq_EPCs_Human1.14499657
102* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14328894
103TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14123776
104IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13953007
105DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.13932786
106VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12153628
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11226947
108SMAD_19615063_ChIP-ChIP_OVARY_Human1.11049742
109TP53_18474530_ChIP-ChIP_U2OS_Human1.10862906
110TCF4_23295773_ChIP-Seq_U87_Human1.10711193
111EZH2_27294783_Chip-Seq_NPCs_Mouse1.10594841
112KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09447778
113GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07891874
114PRDM14_20953172_ChIP-Seq_ESCs_Human1.07380731
115AR_20517297_ChIP-Seq_VCAP_Human1.06267809
116CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05719425
117SMAD4_21741376_ChIP-Seq_HESCs_Human1.05343868
118NANOG_18555785_Chip-Seq_ESCs_Mouse1.05011756
119BCAT_22108803_ChIP-Seq_LS180_Human1.04517188
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04031448
121FLI1_21867929_ChIP-Seq_TH2_Mouse1.03278618
122NCOR_22424771_ChIP-Seq_293T_Human1.02622709
123TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01851447
124RING1B_27294783_Chip-Seq_NPCs_Mouse1.01685125
125IRF1_19129219_ChIP-ChIP_H3396_Human1.01511014
126POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01024824
127MYC_18940864_ChIP-ChIP_HL60_Human1.00511741
128TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00310906
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00048277
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99961039
131FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99689095
132EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99638384
133TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98702410
134RUNX2_22187159_ChIP-Seq_PCA_Human0.98541920
135SMAD3_21741376_ChIP-Seq_HESCs_Human0.98123833
136HOXB7_26014856_ChIP-Seq_BT474_Human0.97843514
137OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96880576
138KDM2B_26808549_Chip-Seq_K562_Human0.96740162
139ISL1_27105846_Chip-Seq_CPCs_Mouse0.96426868
140CDX2_22108803_ChIP-Seq_LS180_Human0.94852257
141NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94572752
142NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94572752
143HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94348950
144SMAD3_21741376_ChIP-Seq_ESCs_Human0.94250258
145ERG_21242973_ChIP-ChIP_JURKAT_Human0.93444034
146ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93201564
147P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92376996
148TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92185149
149MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91508470
150CBX2_27304074_Chip-Seq_ESCs_Mouse0.91440862

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.69697537
2MP0009780_abnormal_chondrocyte_physiolo3.34466448
3MP0003635_abnormal_synaptic_transmissio2.91857510
4MP0004270_analgesia2.85675518
5MP0002909_abnormal_adrenal_gland2.76767933
6MP0003195_calcinosis2.50428947
7MP0008877_abnormal_DNA_methylation2.45888690
8MP0002837_dystrophic_cardiac_calcinosis2.40136986
9MP0002876_abnormal_thyroid_physiology2.39162156
10MP0002063_abnormal_learning/memory/cond2.27810329
11MP0002102_abnormal_ear_morphology2.26918100
12MP0000013_abnormal_adipose_tissue2.24040503
13MP0003283_abnormal_digestive_organ2.15059293
14MP0003136_yellow_coat_color2.12297883
15MP0002653_abnormal_ependyma_morphology2.11474598
16MP0004147_increased_porphyrin_level2.10993204
17MP0004858_abnormal_nervous_system2.07126085
18MP0001299_abnormal_eye_distance/1.99321224
19MP0001486_abnormal_startle_reflex1.94136820
20MP0002572_abnormal_emotion/affect_behav1.92023127
21MP0009745_abnormal_behavioral_response1.89461011
22MP0002938_white_spotting1.86892153
23MP0002734_abnormal_mechanical_nocicepti1.86886562
24MP0003045_fibrosis1.84638112
25MP0002064_seizures1.81958546
26MP0005646_abnormal_pituitary_gland1.81883720
27MP0004885_abnormal_endolymph1.80904477
28MP0009046_muscle_twitch1.73183087
29MP0005423_abnormal_somatic_nervous1.71246274
30MP0006276_abnormal_autonomic_nervous1.70137689
31MP0000778_abnormal_nervous_system1.67222308
32MP0003646_muscle_fatigue1.66816086
33MP0003880_abnormal_central_pattern1.66328717
34MP0003122_maternal_imprinting1.61359167
35MP0004133_heterotaxia1.59578958
36MP0004142_abnormal_muscle_tone1.56605332
37MP0006292_abnormal_olfactory_placode1.53103642
38MP0002272_abnormal_nervous_system1.51371373
39MP0001485_abnormal_pinna_reflex1.50606597
40MP0008569_lethality_at_weaning1.48984163
41MP0001986_abnormal_taste_sensitivity1.47621088
42MP0001968_abnormal_touch/_nociception1.46950491
43MP0004272_abnormal_basement_membrane1.44420098
44MP0000751_myopathy1.42384080
45MP0003183_abnormal_peptide_metabolism1.42322706
46MP0002735_abnormal_chemical_nociception1.41730918
47MP0009384_cardiac_valve_regurgitation1.41199490
48MP0000427_abnormal_hair_cycle1.40391044
49MP0008872_abnormal_physiological_respon1.39130522
50MP0002557_abnormal_social/conspecific_i1.38803660
51MP0000372_irregular_coat_pigmentation1.36710893
52MP0001984_abnormal_olfaction1.36636774
53MP0002184_abnormal_innervation1.35072699
54MP0002067_abnormal_sensory_capabilities1.34620046
55MP0008775_abnormal_heart_ventricle1.34215950
56MP0002877_abnormal_melanocyte_morpholog1.32858140
57MP0010386_abnormal_urinary_bladder1.32642187
58MP0005253_abnormal_eye_physiology1.32560520
59MP0000569_abnormal_digit_pigmentation1.31549120
60MP0008961_abnormal_basal_metabolism1.31167899
61MP0003137_abnormal_impulse_conducting1.30363448
62MP0010368_abnormal_lymphatic_system1.30211353
63MP0005084_abnormal_gallbladder_morpholo1.29929773
64MP0005645_abnormal_hypothalamus_physiol1.28958870
65MP0005503_abnormal_tendon_morphology1.28634449
66MP0004811_abnormal_neuron_physiology1.28633612
67MP0004742_abnormal_vestibular_system1.28411715
68MP0002733_abnormal_thermal_nociception1.28123756
69MP0004085_abnormal_heartbeat1.27324484
70MP0001970_abnormal_pain_threshold1.26467395
71MP0004233_abnormal_muscle_weight1.26297549
72MP0004215_abnormal_myocardial_fiber1.25107505
73MP0005187_abnormal_penis_morphology1.24535912
74MP0002138_abnormal_hepatobiliary_system1.22565816
75MP0000955_abnormal_spinal_cord1.21383938
76MP0008875_abnormal_xenobiotic_pharmacok1.20485129
77MP0004145_abnormal_muscle_electrophysio1.17665305
78MP0002234_abnormal_pharynx_morphology1.16958863
79MP0001529_abnormal_vocalization1.15924422
80MP0000534_abnormal_ureter_morphology1.15918231
81MP0000003_abnormal_adipose_tissue1.15523516
82MP0002882_abnormal_neuron_morphology1.14485166
83MP0002638_abnormal_pupillary_reflex1.10538949
84MP0002822_catalepsy1.10115561
85MP0005377_hearing/vestibular/ear_phenot1.09340149
86MP0003878_abnormal_ear_physiology1.09340149
87MP0004924_abnormal_behavior1.09140988
88MP0005386_behavior/neurological_phenoty1.09140988
89MP0001188_hyperpigmentation1.08356723
90MP0002108_abnormal_muscle_morphology1.07611169
91MP0003633_abnormal_nervous_system1.06453499
92MP0005257_abnormal_intraocular_pressure1.05198343
93MP0002896_abnormal_bone_mineralization1.04924181
94MP0001440_abnormal_grooming_behavior1.03991194
95MP0000026_abnormal_inner_ear1.03824877
96MP0005332_abnormal_amino_acid1.03771888
97MP0001944_abnormal_pancreas_morphology1.03637667
98MP0001905_abnormal_dopamine_level1.02699815
99MP0001293_anophthalmia1.02343745
100MP0003705_abnormal_hypodermis_morpholog1.01991526
101MP0000230_abnormal_systemic_arterial1.01643057
102MP0003300_gastrointestinal_ulcer1.01153053
103MP0003329_amyloid_beta_deposits0.99877557
104MP0003634_abnormal_glial_cell0.99242837
105MP0002254_reproductive_system_inflammat0.99242172
106MP0001502_abnormal_circadian_rhythm0.99031276
107MP0000631_abnormal_neuroendocrine_gland0.98119926
108MP0003787_abnormal_imprinting0.97804549
109MP0005167_abnormal_blood-brain_barrier0.97730839
110MP0002229_neurodegeneration0.96571420
111MP0003718_maternal_effect0.96377964
112MP0005195_abnormal_posterior_eye0.96000830
113MP0003690_abnormal_glial_cell0.94728890
114MP0000383_abnormal_hair_follicle0.94446037
115MP0005174_abnormal_tail_pigmentation0.93785019
116MP0001177_atelectasis0.93628095
117MP0001963_abnormal_hearing_physiology0.93623448
118MP0005171_absent_coat_pigmentation0.93072600
119MP0003011_delayed_dark_adaptation0.92715643
120MP0005551_abnormal_eye_electrophysiolog0.92285134
121MP0002152_abnormal_brain_morphology0.92098876
122MP0002928_abnormal_bile_duct0.92052127
123MP0000538_abnormal_urinary_bladder0.90143424
124MP0006072_abnormal_retinal_apoptosis0.90138398
125MP0005499_abnormal_olfactory_system0.89312530
126MP0005394_taste/olfaction_phenotype0.89312530
127MP0002736_abnormal_nociception_after0.88937286
128MP0005367_renal/urinary_system_phenotyp0.88812884
129MP0000516_abnormal_urinary_system0.88812884
130MP0002066_abnormal_motor_capabilities/c0.88579144
131MP0000749_muscle_degeneration0.88429292
132MP0005623_abnormal_meninges_morphology0.87494959
133MP0002163_abnormal_gland_morphology0.86368883
134MP0003385_abnormal_body_wall0.85767294
135MP0004084_abnormal_cardiac_muscle0.85726203
136MP0001501_abnormal_sleep_pattern0.85718605
137MP0002752_abnormal_somatic_nervous0.84389745
138MP0003631_nervous_system_phenotype0.83751304
139MP0002693_abnormal_pancreas_physiology0.82497251
140MP0004043_abnormal_pH_regulation0.82424862
141MP0002751_abnormal_autonomic_nervous0.82103529
142MP0000613_abnormal_salivary_gland0.81896055
143MP0002090_abnormal_vision0.79958579
144MP0001324_abnormal_eye_pigmentation0.79924185
145MP0000647_abnormal_sebaceous_gland0.79389745
146MP0008438_abnormal_cutaneous_collagen0.78216170
147MP0004036_abnormal_muscle_relaxation0.78178356
148MP0005379_endocrine/exocrine_gland_phen0.78157790
149MP0003632_abnormal_nervous_system0.74199883
150MP0005620_abnormal_muscle_contractility0.72414387

Predicted human phenotypes

RankGene SetZ-score
1Molar tooth sign on MRI (HP:0002419)4.69555244
2Abnormality of midbrain morphology (HP:0002418)4.69555244
3Pancreatic cysts (HP:0001737)4.61827450
4Nephronophthisis (HP:0000090)4.40697391
5True hermaphroditism (HP:0010459)4.32298738
6Pancreatic fibrosis (HP:0100732)4.22078677
7Abnormality of the renal medulla (HP:0100957)3.77696055
8Abnormality of the renal cortex (HP:0011035)3.73341758
9Focal motor seizures (HP:0011153)3.66201845
10Congenital stationary night blindness (HP:0007642)3.46994824
11Focal seizures (HP:0007359)3.43171962
12Chronic hepatic failure (HP:0100626)3.32605443
13Epileptic encephalopathy (HP:0200134)3.32316777
14Myokymia (HP:0002411)3.30594323
15Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.24271926
16Type II lissencephaly (HP:0007260)3.24139005
17Action tremor (HP:0002345)3.13538777
18Hyperinsulinemic hypoglycemia (HP:0000825)3.00588682
19Increased corneal curvature (HP:0100692)2.99082118
20Keratoconus (HP:0000563)2.99082118
21Hypoglycemic seizures (HP:0002173)2.97708657
22Attenuation of retinal blood vessels (HP:0007843)2.95172661
23Gaze-evoked nystagmus (HP:0000640)2.90902291
24Cystic liver disease (HP:0006706)2.90243398
25Abolished electroretinogram (ERG) (HP:0000550)2.86580692
26Prolonged QT interval (HP:0001657)2.83836068
27Renal cortical cysts (HP:0000803)2.81674142
28Tubular atrophy (HP:0000092)2.81009094
29Retinal dysplasia (HP:0007973)2.78304833
30Inability to walk (HP:0002540)2.78015942
31Large for gestational age (HP:0001520)2.77156383
32Progressive cerebellar ataxia (HP:0002073)2.72335934
33Abnormality of the labia minora (HP:0012880)2.68796368
34Medial flaring of the eyebrow (HP:0010747)2.62296803
35Symptomatic seizures (HP:0011145)2.61849303
36EEG with generalized epileptiform discharges (HP:0011198)2.61110757
37Pendular nystagmus (HP:0012043)2.60379726
38Atonic seizures (HP:0010819)2.60032694
39Genetic anticipation (HP:0003743)2.58035553
40Epileptiform EEG discharges (HP:0011182)2.57785501
41Sclerocornea (HP:0000647)2.55036974
42Hypsarrhythmia (HP:0002521)2.54879796
43Visual hallucinations (HP:0002367)2.52683338
44Abnormal drinking behavior (HP:0030082)2.50538011
45Polydipsia (HP:0001959)2.50538011
46Neoplasm of the heart (HP:0100544)2.49619712
47Macroorchidism (HP:0000053)2.49429545
48Abnormal rod and cone electroretinograms (HP:0008323)2.44350727
49Tachypnea (HP:0002789)2.44190585
50Hypothermia (HP:0002045)2.39956832
51Aplasia/Hypoplasia of the tongue (HP:0010295)2.39605542
52Febrile seizures (HP:0002373)2.38962368
53Insulin-resistant diabetes mellitus (HP:0000831)2.33217949
54Congenital hepatic fibrosis (HP:0002612)2.31779283
55Agitation (HP:0000713)2.30930641
56Oligodactyly (hands) (HP:0001180)2.29275121
57Abnormality of calcium-phosphate metabolism (HP:0100530)2.28259083
58Shallow orbits (HP:0000586)2.28015019
59Furrowed tongue (HP:0000221)2.27065518
60Optic nerve hypoplasia (HP:0000609)2.25111149
61Overgrowth (HP:0001548)2.23965192
62Excessive salivation (HP:0003781)2.22510514
63Drooling (HP:0002307)2.22510514
64Ketosis (HP:0001946)2.22015628
65Proximal tubulopathy (HP:0000114)2.21901636
66Absent rod-and cone-mediated responses on ERG (HP:0007688)2.21356577
67Progressive inability to walk (HP:0002505)2.19349600
68Hepatoblastoma (HP:0002884)2.17847465
69Depression (HP:0000716)2.17407573
70Postaxial foot polydactyly (HP:0001830)2.17359733
71Lissencephaly (HP:0001339)2.14883190
72Decreased central vision (HP:0007663)2.14290223
73Dynein arm defect of respiratory motile cilia (HP:0012255)2.12217746
74Absent/shortened dynein arms (HP:0200106)2.12217746
75Papilledema (HP:0001085)2.11049343
76Protruding tongue (HP:0010808)2.10160491
77Megalencephaly (HP:0001355)2.10121676
78Hyperglycemia (HP:0003074)2.08700318
79Patellar aplasia (HP:0006443)2.08684683
80Short 4th metacarpal (HP:0010044)2.08647692
81Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.08647692
82Methylmalonic acidemia (HP:0002912)2.05687948
83Chorioretinal atrophy (HP:0000533)2.05671257
84Abnormal EKG (HP:0003115)2.05616240
85Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.04193549
86Absence seizures (HP:0002121)2.03789987
87Bronchomalacia (HP:0002780)2.03760640
88Supranuclear gaze palsy (HP:0000605)2.01999942
89Methylmalonic aciduria (HP:0012120)2.00570178
90Male pseudohermaphroditism (HP:0000037)2.00281955
91Generalized tonic-clonic seizures (HP:0002069)2.00013293
92Abnormality of alanine metabolism (HP:0010916)1.99498905
93Hyperalaninemia (HP:0003348)1.99498905
94Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99498905
95Aqueductal stenosis (HP:0002410)1.98450879
96Polyuria (HP:0000103)1.97996487
97Atrial fibrillation (HP:0005110)1.97950060
98Polyphagia (HP:0002591)1.97614570
99Urinary bladder sphincter dysfunction (HP:0002839)1.97543629
100Hypoglycemic coma (HP:0001325)1.97513527
101Fair hair (HP:0002286)1.97382428
102Aplasia/Hypoplasia of the patella (HP:0006498)1.97208602
103Truncal ataxia (HP:0002078)1.96919065
104Congenital sensorineural hearing impairment (HP:0008527)1.95852695
105Gait imbalance (HP:0002141)1.95759263
106Vascular tortuosity (HP:0004948)1.95431803
107Widely spaced teeth (HP:0000687)1.95387166
108Primary atrial arrhythmia (HP:0001692)1.95115660
109Aplasia/Hypoplasia of the tibia (HP:0005772)1.94716273
110Broad metatarsal (HP:0001783)1.94410958
111Abnormality of endocrine pancreas physiology (HP:0012093)1.94217674
112Abnormality of the pancreatic islet cells (HP:0006476)1.94217674
113Nephrogenic diabetes insipidus (HP:0009806)1.94081276
114Broad-based gait (HP:0002136)1.93155546
115Hemiparesis (HP:0001269)1.93045385
116Neurofibrillary tangles (HP:0002185)1.92536850
117Anencephaly (HP:0002323)1.90826019
118Acute necrotizing encephalopathy (HP:0006965)1.90751955
119Pancreatic islet-cell hyperplasia (HP:0004510)1.88682176
120Dysdiadochokinesis (HP:0002075)1.88453642
121Hemiplegia (HP:0002301)1.88228091
122Ankle clonus (HP:0011448)1.87829185
123Pachygyria (HP:0001302)1.86581167
124Bradycardia (HP:0001662)1.86250713
125Bulbous nose (HP:0000414)1.84493995
126Confusion (HP:0001289)1.84447220
127Dialeptic seizures (HP:0011146)1.84309752
128Cerebellar dysplasia (HP:0007033)1.83693019
129Congenital primary aphakia (HP:0007707)1.83197046
130Ulnar claw (HP:0001178)1.82507443
131Disproportionate short-trunk short stature (HP:0003521)1.82058618
132Poor eye contact (HP:0000817)1.81876695
133Congenital, generalized hypertrichosis (HP:0004540)1.81871669
134Abnormal social behavior (HP:0012433)1.79984726
135Impaired social interactions (HP:0000735)1.79984726
136Hypoplastic ischia (HP:0003175)1.79929356
137Abnormal biliary tract physiology (HP:0012439)1.79862131
138Bile duct proliferation (HP:0001408)1.79862131
139Mitochondrial inheritance (HP:0001427)1.79689813
140Postaxial hand polydactyly (HP:0001162)1.78979732
141Abnormality of macular pigmentation (HP:0008002)1.78472349
142Torticollis (HP:0000473)1.78014271
143Hypoplasia of the pons (HP:0012110)1.77694923
144Abnormality of the pons (HP:0007361)1.77501562
145Anxiety (HP:0000739)1.76907180
146Postural instability (HP:0002172)1.76849452
147Severe muscular hypotonia (HP:0006829)1.76501763
148Optic disc pallor (HP:0000543)1.75998712
149Supraventricular tachycardia (HP:0004755)1.74980661
150Absent speech (HP:0001344)1.74904492
151Cerebral inclusion bodies (HP:0100314)1.73953633
152Supraventricular arrhythmia (HP:0005115)1.73741456
153Ketoacidosis (HP:0001993)1.73658496
154Labial hypoplasia (HP:0000066)1.73140513
155Pheochromocytoma (HP:0002666)1.73123155
156Impaired vibration sensation in the lower limbs (HP:0002166)1.71439822
157Clumsiness (HP:0002312)1.71123340
158Genital tract atresia (HP:0001827)1.70377822
159Increased CSF lactate (HP:0002490)1.70366449
160Enlarged penis (HP:0000040)1.70256855
161Decreased electroretinogram (ERG) amplitude (HP:0000654)1.69133398
162Hyperventilation (HP:0002883)1.69086928
163Anophthalmia (HP:0000528)1.69008172
164Bony spicule pigmentary retinopathy (HP:0007737)1.68834172
165Aplasia involving bones of the extremities (HP:0009825)1.68555403
166Aplasia involving bones of the upper limbs (HP:0009823)1.68555403
167Aplasia of the phalanges of the hand (HP:0009802)1.68555403
168Open mouth (HP:0000194)1.67948682
169Cutaneous finger syndactyly (HP:0010554)1.67914094
170Impaired smooth pursuit (HP:0007772)1.66811693
171Bundle branch block (HP:0011710)1.66750176
172Decreased circulating renin level (HP:0003351)1.66521208
173Turricephaly (HP:0000262)1.65722612
174Central scotoma (HP:0000603)1.64840825
175Stereotypic behavior (HP:0000733)1.64599059
176Aneurysm (HP:0002617)1.64468405
177Elfin facies (HP:0004428)1.63420285
178Arterial tortuosity (HP:0005116)1.63182638
179Vertebral arch anomaly (HP:0008438)1.63047831
180Microglossia (HP:0000171)1.62940747
181Aortic aneurysm (HP:0004942)1.61151321
182Cerebral aneurysm (HP:0004944)1.60745542
183Sudden death (HP:0001699)1.59411309
184Obsessive-compulsive behavior (HP:0000722)1.59085314
185Bladder diverticulum (HP:0000015)1.58807258
186Abnormality of the 4th metacarpal (HP:0010012)1.58610899
187Dysmetric saccades (HP:0000641)1.58354196
188Blue irides (HP:0000635)1.56943500
189Syncope (HP:0001279)1.56243882
190Myotonia (HP:0002486)1.54819674

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR3.76461891
2NTRK33.48837455
3ADRBK23.36696371
4PRKD33.36637258
5BMPR1B3.31858381
6MARK12.98310299
7MAP4K22.67499836
8GRK12.62498600
9ACVR1B2.53500565
10WNK42.45878206
11TLK12.34423468
12EPHA42.25983679
13MAP3K42.15641651
14SIK12.01249556
15NTRK11.99720615
16MAP3K91.88224725
17NTRK21.86209888
18CAMK1G1.80897358
19MINK11.75628439
20PINK11.72186051
21ZAK1.70791453
22MAP2K71.67615835
23EPHA31.62609176
24FRK1.60094203
25PHKG21.55371309
26PHKG11.55371309
27MAP3K21.51798670
28TNIK1.51548630
29LATS11.44622908
30PDGFRA1.44570602
31CASK1.39844527
32PAK61.38435274
33CAMK1D1.37800073
34TAOK31.36413864
35PRKCH1.36269365
36TYRO31.33510375
37KSR11.31735844
38DMPK1.31233952
39SGK2231.29361458
40SGK4941.29361458
41BCKDK1.26378759
42MAPK131.26015620
43PAK31.25020368
44TGFBR11.24154142
45STK381.22905185
46CAMKK11.22428097
47EPHB21.21149239
48SGK21.20160999
49OXSR11.19527377
50CDK51.18957355
51MAP2K41.17924597
52KSR21.17045284
53WNK31.15949099
54CDC42BPA1.15569167
55DYRK21.15528657
56STK391.14523676
57ADRBK11.13404421
58MARK21.10039789
59NEK11.10027007
60RET1.08132071
61AKT31.03410311
62CAMKK21.02980123
63MAP2K61.02308631
64DAPK21.01693471
65MKNK21.00401725
66SGK31.00116290
67FES0.98071987
68SIK20.96773540
69LMTK20.95615143
70UHMK10.94759365
71PRPF4B0.93038725
72TXK0.89570291
73MAPKAPK50.89149476
74PNCK0.88961248
75PTK20.85969087
76MAPKAPK30.85819612
77TRIM280.85473809
78PRKCG0.83443716
79SIK30.82594311
80WNK10.81954887
81TIE10.81661086
82DDR20.78364525
83PRKCE0.77173782
84CAMK10.76313025
85FER0.75899754
86PTK2B0.75372842
87PIK3CA0.75133707
88SGK10.74815313
89RIPK10.73611053
90FLT30.72242761
91ERBB30.71592262
92LATS20.69499155
93MYLK0.68354465
94NEK20.67742375
95PDGFRB0.66873104
96ERBB20.66724150
97PLK40.65763654
98STK38L0.65607429
99LIMK10.65350959
100CAMK40.64030380
101PRKD20.64002390
102VRK10.63997279
103CAMK2A0.63938882
104RPS6KA60.63238761
105CSNK1G20.62805235
106FGFR20.61914786
107PRKAA10.60599860
108MAPK150.59398337
109MAP3K10.56689534
110DYRK1A0.55722223
111OBSCN0.55577514
112MUSK0.55545279
113ROCK10.55285336
114TNK20.54819588
115CSNK1G10.54321780
116BRSK20.53347070
117MAP3K70.53258166
118ICK0.52700796
119RPS6KA30.52488860
120RPS6KA50.51928229
121PTK60.51631266
122NUAK10.51532762
123HIPK20.51412452
124NEK60.50753569
125GRK70.50696907
126PRKACA0.50533881
127FGFR10.49719461
128PLK20.49456854
129SCYL20.48968085
130KIT0.48419986
131PRKD10.48205551
132NLK0.47826573
133CSNK1A10.47514701
134DAPK10.46962986
135PKN10.46887377
136PRKAA20.46202768
137BCR0.46102819
138MAPK100.45231605
139CAMK2D0.45045193
140STK30.44933746
141CSNK1G30.44805328
142ALK0.44027360
143MAPK70.43843486
144RPS6KA20.43786036
145PRKCI0.43045431
146PRKCZ0.42851420
147STK110.42553038
148PRKCQ0.42380619
149FYN0.41796961
150MST40.41571496
151IRAK10.41133385
152TAOK10.41013569
153CCNB10.40713485
154PRKCA0.40302787
155TRIB30.40049981
156CDK140.39787650
157CDK30.39125422

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.82285999
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.75046418
3Insulin secretion_Homo sapiens_hsa049112.66121776
4Linoleic acid metabolism_Homo sapiens_hsa005912.64765093
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.49123421
6Selenocompound metabolism_Homo sapiens_hsa004502.46636042
7Butanoate metabolism_Homo sapiens_hsa006502.44209483
8Circadian entrainment_Homo sapiens_hsa047132.31198102
9Nicotine addiction_Homo sapiens_hsa050332.25169725
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.24188167
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.11808423
12Long-term potentiation_Homo sapiens_hsa047202.05419852
13GABAergic synapse_Homo sapiens_hsa047272.01536908
14Glutamatergic synapse_Homo sapiens_hsa047241.99710153
15Type II diabetes mellitus_Homo sapiens_hsa049301.96271788
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.94503378
17Ether lipid metabolism_Homo sapiens_hsa005651.93600123
18Cholinergic synapse_Homo sapiens_hsa047251.91730536
19Olfactory transduction_Homo sapiens_hsa047401.91220593
20Amphetamine addiction_Homo sapiens_hsa050311.87395040
21Morphine addiction_Homo sapiens_hsa050321.84970223
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.84965875
23Synaptic vesicle cycle_Homo sapiens_hsa047211.83777953
24Tryptophan metabolism_Homo sapiens_hsa003801.81075608
25Dopaminergic synapse_Homo sapiens_hsa047281.76026984
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.75980105
27Oxidative phosphorylation_Homo sapiens_hsa001901.75407065
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.69881327
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.65622474
30Salivary secretion_Homo sapiens_hsa049701.62704097
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61555323
32Protein export_Homo sapiens_hsa030601.55937388
33Renin secretion_Homo sapiens_hsa049241.53973029
34Dilated cardiomyopathy_Homo sapiens_hsa054141.53832475
35Cocaine addiction_Homo sapiens_hsa050301.52888478
36Caffeine metabolism_Homo sapiens_hsa002321.52400689
37Gastric acid secretion_Homo sapiens_hsa049711.52231862
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.47783381
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45885021
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.42136413
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40556469
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.37053074
43Taste transduction_Homo sapiens_hsa047421.36999135
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.36558566
45Oxytocin signaling pathway_Homo sapiens_hsa049211.33741918
46Axon guidance_Homo sapiens_hsa043601.32149871
47Propanoate metabolism_Homo sapiens_hsa006401.31613414
48Gap junction_Homo sapiens_hsa045401.29829914
49Long-term depression_Homo sapiens_hsa047301.29822326
50cAMP signaling pathway_Homo sapiens_hsa040241.28661816
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.27143726
52cGMP-PKG signaling pathway_Homo sapiens_hsa040221.25980624
53Calcium signaling pathway_Homo sapiens_hsa040201.24368745
54RNA polymerase_Homo sapiens_hsa030201.23611875
55Parkinsons disease_Homo sapiens_hsa050121.22489620
56Serotonergic synapse_Homo sapiens_hsa047261.21747433
57Homologous recombination_Homo sapiens_hsa034401.20193880
58Sulfur metabolism_Homo sapiens_hsa009201.19945695
59Melanogenesis_Homo sapiens_hsa049161.18744536
60Estrogen signaling pathway_Homo sapiens_hsa049151.18644878
61Arachidonic acid metabolism_Homo sapiens_hsa005901.18555003
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.17249547
63GnRH signaling pathway_Homo sapiens_hsa049121.16930366
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.16392832
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15498940
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15026357
67Chemical carcinogenesis_Homo sapiens_hsa052041.14628666
68Fat digestion and absorption_Homo sapiens_hsa049751.11690746
69Peroxisome_Homo sapiens_hsa041461.10425736
70Basal transcription factors_Homo sapiens_hsa030221.09719891
71Steroid hormone biosynthesis_Homo sapiens_hsa001401.09679432
72ABC transporters_Homo sapiens_hsa020101.08538056
73Glioma_Homo sapiens_hsa052141.07441071
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06684899
75Vascular smooth muscle contraction_Homo sapiens_hsa042701.05762351
76Thyroid hormone synthesis_Homo sapiens_hsa049181.04999413
77Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03824308
78Glucagon signaling pathway_Homo sapiens_hsa049221.01942667
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97651367
80Retinol metabolism_Homo sapiens_hsa008300.97267460
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96927355
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96772102
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95917771
84Regulation of autophagy_Homo sapiens_hsa041400.92915515
85Pancreatic secretion_Homo sapiens_hsa049720.91953528
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89849479
87Dorso-ventral axis formation_Homo sapiens_hsa043200.89826320
88Huntingtons disease_Homo sapiens_hsa050160.89739310
89Fatty acid metabolism_Homo sapiens_hsa012120.89031674
90Fatty acid elongation_Homo sapiens_hsa000620.88559306
91ErbB signaling pathway_Homo sapiens_hsa040120.88473595
92Alzheimers disease_Homo sapiens_hsa050100.87420084
93Wnt signaling pathway_Homo sapiens_hsa043100.85653369
94Fatty acid degradation_Homo sapiens_hsa000710.85014673
95Adherens junction_Homo sapiens_hsa045200.84725891
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83407588
97Mineral absorption_Homo sapiens_hsa049780.81320011
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80549342
99Circadian rhythm_Homo sapiens_hsa047100.79722004
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.77477006
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77288057
102Insulin resistance_Homo sapiens_hsa049310.76876074
103Endometrial cancer_Homo sapiens_hsa052130.76784633
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76610575
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.76258746
106Nitrogen metabolism_Homo sapiens_hsa009100.75922747
107mTOR signaling pathway_Homo sapiens_hsa041500.75676939
108Insulin signaling pathway_Homo sapiens_hsa049100.72723799
109Intestinal immune network for IgA production_Homo sapiens_hsa046720.72470592
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.72456768
111Fanconi anemia pathway_Homo sapiens_hsa034600.72191484
112Phototransduction_Homo sapiens_hsa047440.71403333
113Focal adhesion_Homo sapiens_hsa045100.71290794
114Prion diseases_Homo sapiens_hsa050200.70892494
115Rap1 signaling pathway_Homo sapiens_hsa040150.69590482
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68641767
117beta-Alanine metabolism_Homo sapiens_hsa004100.68487041
118Basal cell carcinoma_Homo sapiens_hsa052170.67719566
119Hedgehog signaling pathway_Homo sapiens_hsa043400.67275901
120Histidine metabolism_Homo sapiens_hsa003400.66311513
121Vitamin digestion and absorption_Homo sapiens_hsa049770.66049394
122Choline metabolism in cancer_Homo sapiens_hsa052310.65860165
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65555597
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65551975
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65368797
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63526458
127MAPK signaling pathway_Homo sapiens_hsa040100.62035038
128Vibrio cholerae infection_Homo sapiens_hsa051100.61579542
129Colorectal cancer_Homo sapiens_hsa052100.61573800
130Cardiac muscle contraction_Homo sapiens_hsa042600.61236064
131Glycerolipid metabolism_Homo sapiens_hsa005610.60865886
132Proteoglycans in cancer_Homo sapiens_hsa052050.58537699
133Metabolic pathways_Homo sapiens_hsa011000.56398365
134Renal cell carcinoma_Homo sapiens_hsa052110.56012564
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.54885463
136Ras signaling pathway_Homo sapiens_hsa040140.54664737
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54028483
138Hippo signaling pathway_Homo sapiens_hsa043900.53152701
139Collecting duct acid secretion_Homo sapiens_hsa049660.51407550
140Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50844831
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50829256
142Vitamin B6 metabolism_Homo sapiens_hsa007500.50451143
143AMPK signaling pathway_Homo sapiens_hsa041520.48827685
144Ovarian steroidogenesis_Homo sapiens_hsa049130.48215783
145One carbon pool by folate_Homo sapiens_hsa006700.47548677
146Purine metabolism_Homo sapiens_hsa002300.47374630
147Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47121114
148Bile secretion_Homo sapiens_hsa049760.47096679
149RNA degradation_Homo sapiens_hsa030180.47072625
150ECM-receptor interaction_Homo sapiens_hsa045120.46602014
151Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46372585
152Glycosaminoglycan degradation_Homo sapiens_hsa005310.45966329
153Type I diabetes mellitus_Homo sapiens_hsa049400.45169983
154Inositol phosphate metabolism_Homo sapiens_hsa005620.44265774
155Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44168579
156Fatty acid biosynthesis_Homo sapiens_hsa000610.43770765
157Lysine degradation_Homo sapiens_hsa003100.43615539
158Protein digestion and absorption_Homo sapiens_hsa049740.42856607
159Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42171505
160Central carbon metabolism in cancer_Homo sapiens_hsa052300.42158760
161Endocytosis_Homo sapiens_hsa041440.41798100
162Prolactin signaling pathway_Homo sapiens_hsa049170.40765236
163Glycerophospholipid metabolism_Homo sapiens_hsa005640.40202758
164Asthma_Homo sapiens_hsa053100.36881045

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