PCDHGA7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.30361258
2locomotory exploration behavior (GO:0035641)5.26454880
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.60313176
4cell communication by electrical coupling (GO:0010644)4.53076311
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.50493139
6sodium ion export (GO:0071436)4.47958037
7cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.36240922
8glutamate secretion (GO:0014047)4.36150405
9synaptic vesicle exocytosis (GO:0016079)4.24109805
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.21254467
11membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.20635049
12regulation of synapse structural plasticity (GO:0051823)4.14669771
13vocalization behavior (GO:0071625)4.07682493
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.05965505
15protein heterotrimerization (GO:0070208)4.05777894
16collagen fibril organization (GO:0030199)4.03834290
17skin morphogenesis (GO:0043589)4.03801967
18chondrocyte proliferation (GO:0035988)4.00834053
19cell adhesion mediated by integrin (GO:0033627)3.98364056
20regulation of axon extension involved in axon guidance (GO:0048841)3.96849170
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.96805311
22cell migration involved in heart development (GO:0060973)3.96699115
23dendritic spine morphogenesis (GO:0060997)3.96033839
24response to auditory stimulus (GO:0010996)3.94042538
25regulation of synaptic vesicle exocytosis (GO:2000300)3.92197079
26mesenchymal-epithelial cell signaling (GO:0060638)3.91545415
27regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.89762208
28layer formation in cerebral cortex (GO:0021819)3.79061505
29cellular potassium ion homeostasis (GO:0030007)3.72750752
30exploration behavior (GO:0035640)3.72318217
31kidney mesenchyme development (GO:0072074)3.70358460
32negative regulation of axon extension involved in axon guidance (GO:0048843)3.70211999
33regulation of glutamate receptor signaling pathway (GO:1900449)3.69795814
34negative regulation of cytosolic calcium ion concentration (GO:0051481)3.69769890
35sequestering of extracellular ligand from receptor (GO:0035581)3.63534423
36regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.58019063
37type B pancreatic cell proliferation (GO:0044342)3.56997850
38endocardial cushion development (GO:0003197)3.55275076
39endodermal cell differentiation (GO:0035987)3.54459152
40neurotransmitter secretion (GO:0007269)3.53623971
41axonal fasciculation (GO:0007413)3.52312707
42response to pheromone (GO:0019236)3.50997858
43neurotransmitter-gated ion channel clustering (GO:0072578)3.50322303
44glomerular basement membrane development (GO:0032836)3.49303478
45regulation of axon guidance (GO:1902667)3.48565350
46neuronal action potential propagation (GO:0019227)3.45438910
47dendrite morphogenesis (GO:0048813)3.45267169
48substrate-dependent cell migration (GO:0006929)3.44644709
49regulation of neuronal synaptic plasticity (GO:0048168)3.43410208
50extracellular matrix assembly (GO:0085029)3.42851977
51metanephric mesenchyme development (GO:0072075)3.39605718
52positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.39071444
53bone trabecula formation (GO:0060346)3.37124586
54neuron projection extension involved in neuron projection guidance (GO:1902284)3.36918617
55axon extension involved in axon guidance (GO:0048846)3.36918617
56regulation of long-term neuronal synaptic plasticity (GO:0048169)3.36373840
57long-term memory (GO:0007616)3.35321836
58neuron cell-cell adhesion (GO:0007158)3.35036468
59positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.34417430
60regulation of synaptic vesicle transport (GO:1902803)3.34156337
61protein localization to synapse (GO:0035418)3.31459978
62ionotropic glutamate receptor signaling pathway (GO:0035235)3.31405177
63hemidesmosome assembly (GO:0031581)3.25981205
64innervation (GO:0060384)3.21360744
65gamma-aminobutyric acid transport (GO:0015812)3.18217387
66auditory behavior (GO:0031223)3.17350227
67establishment of nucleus localization (GO:0040023)3.16829995
68neuromuscular process controlling balance (GO:0050885)3.14769153
69neuron recognition (GO:0008038)3.13593348
70cellular sodium ion homeostasis (GO:0006883)3.13554371
71membrane depolarization during action potential (GO:0086010)3.12749943
72positive regulation of synapse maturation (GO:0090129)3.11305709
73negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.09715789
74regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.08992151
75positive regulation of axon extension (GO:0045773)3.08969921
76smooth muscle tissue development (GO:0048745)3.07381075
77glutamate receptor signaling pathway (GO:0007215)3.06454137
78glomerular visceral epithelial cell development (GO:0072015)3.05809391
79activation of protein kinase A activity (GO:0034199)3.05756672
80cell communication involved in cardiac conduction (GO:0086065)3.05587060
81regulation of synaptic transmission, glutamatergic (GO:0051966)3.02960549
82synaptic transmission, glutamatergic (GO:0035249)3.02105456
83proline transport (GO:0015824)3.00729210
84negative regulation of axon guidance (GO:1902668)3.00434672
85positive regulation of potassium ion transmembrane transport (GO:1901381)2.99086091
86lymphangiogenesis (GO:0001946)2.97935235
87cell-substrate junction assembly (GO:0007044)2.96266147
88positive regulation of fibroblast migration (GO:0010763)2.91731516
89regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.90871619
90cytoskeletal anchoring at plasma membrane (GO:0007016)2.90808987
91prepulse inhibition (GO:0060134)2.90488465
92regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.90118083
93cerebellar granule cell differentiation (GO:0021707)2.89736763
94potassium ion import (GO:0010107)2.89485023
95fibroblast migration (GO:0010761)2.88832821
96neuron-neuron synaptic transmission (GO:0007270)2.87640661
97negative regulation of osteoblast proliferation (GO:0033689)2.87635065
98regulation of neurotransmitter secretion (GO:0046928)2.87447792
99long-term synaptic potentiation (GO:0060291)2.84894471
100regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.84835941
101negative regulation of cell size (GO:0045792)2.83132322
102potassium ion homeostasis (GO:0055075)2.82849838
103central nervous system projection neuron axonogenesis (GO:0021952)2.82474823
104negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.80595075
105neuronal ion channel clustering (GO:0045161)2.79401269
106cerebellar Purkinje cell differentiation (GO:0021702)2.79253444
107heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.78662487
108cellular response to vitamin (GO:0071295)2.78272526
109regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.78194720
110cell migration in hindbrain (GO:0021535)2.77742746
111glial cell proliferation (GO:0014009)2.77202369
112negative regulation of smooth muscle cell migration (GO:0014912)2.76142093
113regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.75810236
114membrane repolarization (GO:0086009)2.75060673
115regulation of synaptic plasticity (GO:0048167)2.74908840
116regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.74857350
117positive regulation of blood vessel endothelial cell migration (GO:0043536)2.74569289
118neurotransmitter transport (GO:0006836)2.74515210
119blood vessel maturation (GO:0001955)2.73781493
120G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.72272474
121regulation of excitatory postsynaptic membrane potential (GO:0060079)2.70839144
122postsynaptic membrane organization (GO:0001941)2.70376309
123synapse assembly (GO:0007416)2.70028644
124retina vasculature morphogenesis in camera-type eye (GO:0061299)2.69614783
125vascular endothelial growth factor signaling pathway (GO:0038084)2.69608482
126hippo signaling (GO:0035329)2.69361840
127regulation of neurotransmitter transport (GO:0051588)2.68776614
128collagen metabolic process (GO:0032963)2.66709927
129transmission of nerve impulse (GO:0019226)2.65885950
130dendritic spine organization (GO:0097061)2.65871196
131cerebellar Purkinje cell layer development (GO:0021680)2.65434089
132positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.64684140
133regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.64401255
134planar cell polarity pathway involved in neural tube closure (GO:0090179)2.64013393
135positive regulation of membrane potential (GO:0045838)2.63487574
136insulin-like growth factor receptor signaling pathway (GO:0048009)2.63051518
137glomerular epithelial cell development (GO:0072310)2.62146428
138cell migration involved in sprouting angiogenesis (GO:0002042)2.61705327
139regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.61643868
140synapse organization (GO:0050808)2.61366863
141regulation of membrane repolarization (GO:0060306)2.59817809
142regulation of postsynaptic membrane potential (GO:0060078)2.59488857
143adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.59216328
144COPII vesicle coating (GO:0048208)2.58319572
145synaptic vesicle endocytosis (GO:0048488)2.56187519
146substrate adhesion-dependent cell spreading (GO:0034446)2.55931540
147positive regulation of synaptic transmission, GABAergic (GO:0032230)2.55694057
148dermatan sulfate metabolic process (GO:0030205)2.55586826
149regulation of dendritic spine morphogenesis (GO:0061001)2.55540497
150regulation of neurotransmitter levels (GO:0001505)2.55315095
151positive regulation of potassium ion transport (GO:0043268)2.55215747
152striatum development (GO:0021756)2.54151319
153dermatan sulfate biosynthetic process (GO:0030208)2.54030833
154negative regulation of chondrocyte differentiation (GO:0032331)2.52954801
155vesicle transport along microtubule (GO:0047496)2.52856024
156regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.52688900
157regulation of potassium ion transmembrane transport (GO:1901379)2.52514068
158axon extension (GO:0048675)2.50780739
159pericardium development (GO:0060039)2.50308580
160desmosome organization (GO:0002934)2.49588011
161membrane depolarization (GO:0051899)2.49493852
162chondrocyte development (GO:0002063)2.49272249
163cardiac myofibril assembly (GO:0055003)2.48913249
164multicellular organismal macromolecule metabolic process (GO:0044259)2.48732273
165collagen catabolic process (GO:0030574)2.48024998
166regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.47291715
167positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.47095429
168endocrine hormone secretion (GO:0060986)2.46333736
169positive regulation of protein autophosphorylation (GO:0031954)2.45858407
170heparin metabolic process (GO:0030202)2.45028100
171heparin biosynthetic process (GO:0030210)2.45028100
172cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.42965402
173dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.41414097
174negative regulation of fatty acid transport (GO:2000192)2.41178127
175ganglion development (GO:0061548)2.40220002
176Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.40150792
177negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.40008239
178wound healing, spreading of epidermal cells (GO:0035313)2.39908725
179extracellular matrix disassembly (GO:0022617)2.39465409
180venous blood vessel morphogenesis (GO:0048845)2.38341586
181multicellular organismal metabolic process (GO:0044236)2.37484149
182extracellular fibril organization (GO:0043206)2.36053599
183negative regulation of stem cell proliferation (GO:2000647)2.35791057
184extracellular matrix organization (GO:0030198)2.35069422
185regulation of establishment of planar polarity (GO:0090175)2.34295127
186extracellular structure organization (GO:0043062)2.34145037
187facial nerve structural organization (GO:0021612)2.34140980
188stress fiber assembly (GO:0043149)2.31426794
189cellular response to vitamin D (GO:0071305)2.31293377
190regulation of transforming growth factor beta2 production (GO:0032909)2.30953687
191embryonic cranial skeleton morphogenesis (GO:0048701)2.30457339
192negative chemotaxis (GO:0050919)2.29022723
193positive regulation of endothelial cell apoptotic process (GO:2000353)2.28413105
194regulation of axon extension (GO:0030516)2.27917041
195regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.27886167
196positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.27484576
197positive regulation of cardiac muscle hypertrophy (GO:0010613)2.24680238
198positive regulation of muscle hypertrophy (GO:0014742)2.24680238

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.58562253
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.32401253
3GBX2_23144817_ChIP-Seq_PC3_Human3.00273092
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.87360656
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.87151099
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71825251
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63264183
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63264183
9DROSHA_22980978_ChIP-Seq_HELA_Human2.57562154
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54318906
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46193504
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.44758664
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44020554
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43221347
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.41575790
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.39946469
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.38167159
18WT1_19549856_ChIP-ChIP_CCG9911_Human2.36135885
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.35854264
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.34667338
21BRD4_25478319_ChIP-Seq_HGPS_Human2.29011441
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.24782591
23REST_21632747_ChIP-Seq_MESCs_Mouse2.22574049
24CJUN_26792858_Chip-Seq_BT549_Human2.18312717
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.18081788
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.16179118
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.14617479
28SUZ12_27294783_Chip-Seq_ESCs_Mouse2.10756460
29IKZF1_21737484_ChIP-ChIP_HCT116_Human2.08016405
30CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.05665405
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.04513471
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.99060765
33TP53_18474530_ChIP-ChIP_U2OS_Human1.99015338
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.96851622
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94016752
36AR_21572438_ChIP-Seq_LNCaP_Human1.91770588
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.90889389
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85828521
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.82577047
40TP63_17297297_ChIP-ChIP_HaCaT_Human1.81594055
41TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.78848709
42NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.64795498
43NRF2_20460467_ChIP-Seq_MEFs_Mouse1.64795498
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56563135
45RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.53662535
46CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.50725353
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47483310
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46844635
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45667676
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.44505968
51WT1_25993318_ChIP-Seq_PODOCYTE_Human1.41416934
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40631054
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39915448
54RING1B_27294783_Chip-Seq_ESCs_Mouse1.39391903
55SMAD4_21799915_ChIP-Seq_A2780_Human1.37942243
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37238780
57ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37019520
58* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.32538007
59* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.32538007
60AR_19668381_ChIP-Seq_PC3_Human1.32441279
61ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32338768
62ESR1_21235772_ChIP-Seq_MCF-7_Human1.32128135
63ZNF274_21170338_ChIP-Seq_K562_Hela1.31785240
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30986219
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29722630
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29664315
67SOX9_24532713_ChIP-Seq_HFSC_Mouse1.28353839
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28228547
69SOX2_21211035_ChIP-Seq_LN229_Gbm1.27762667
70DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26593100
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.26093690
72KDM2B_26808549_Chip-Seq_K562_Human1.25907097
73PPAR_26484153_Chip-Seq_NCI-H1993_Human1.25394540
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.24673217
75* TP53_23651856_ChIP-Seq_MEFs_Mouse1.24155668
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23261336
77RING1B_27294783_Chip-Seq_NPCs_Mouse1.20717531
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20263519
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.19790939
80SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.19130741
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.18535587
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.14815734
83HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13751949
84OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13505966
85MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.13282201
86DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12928328
87YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12815772
88JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12694795
89CLOCK_20551151_ChIP-Seq_293T_Human1.12631909
90TP53_16413492_ChIP-PET_HCT116_Human1.12567091
91EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12443608
92CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12315161
93SMAD4_21741376_ChIP-Seq_HESCs_Human1.10938148
94STAT3_23295773_ChIP-Seq_U87_Human1.10540933
95* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10458088
96AR_25329375_ChIP-Seq_VCAP_Human1.10252117
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09798951
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09158597
99EP300_21415370_ChIP-Seq_HL-1_Mouse1.09106144
100TP53_20018659_ChIP-ChIP_R1E_Mouse1.09054896
101CBX2_27304074_Chip-Seq_ESCs_Mouse1.08766338
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.07468027
103SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07028561
104AHR_22903824_ChIP-Seq_MCF-7_Human1.06899351
105TRIM28_21343339_ChIP-Seq_HEK293_Human1.06529508
106TBX20_22328084_ChIP-Seq_HEART_Mouse1.06111441
107TBX20_22080862_ChIP-Seq_HEART_Mouse1.06111441
108ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05568573
109TCF4_18268006_ChIP-ChIP_LS174T_Human1.04656634
110NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04620386
111TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04027951
112P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03429671
113JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03302828
114KDM2B_26808549_Chip-Seq_REH_Human1.02950629
115ARNT_22903824_ChIP-Seq_MCF-7_Human1.02801255
116RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02783883
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02475710
118NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02370393
119NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02149064
120TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02079569
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01821478
122SMAD3_21741376_ChIP-Seq_HESCs_Human1.01638765
123TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01561550
124PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01417410
125SMAD_19615063_ChIP-ChIP_OVARY_Human1.00938120
126ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99673115
127FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99590512
128TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99362423
129CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99359338
130RXR_22108803_ChIP-Seq_LS180_Human0.99115301
131BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98941799
132RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98656287
133NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97375072
134ESR1_20079471_ChIP-ChIP_T-47D_Human0.96939064
135P300_19829295_ChIP-Seq_ESCs_Human0.96665286
136TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95809508
137SMAD3_21741376_ChIP-Seq_ESCs_Human0.94731939
138ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93426191
139MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92352711
140TCF4_23295773_ChIP-Seq_U87_Human0.91589890
141SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88585684
142CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88157597
143TET1_21490601_ChIP-Seq_MESCs_Mouse0.87765729
144THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86614946
145GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85598779
146ISL1_27105846_Chip-Seq_CPCs_Mouse0.85165352

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.92722532
2MP0003705_abnormal_hypodermis_morpholog4.18411117
3MP0005275_abnormal_skin_tensile3.83306066
4MP0003635_abnormal_synaptic_transmissio3.51865377
5MP0004270_analgesia3.43288484
6MP0004272_abnormal_basement_membrane3.28884012
7MP0001958_emphysema3.08824138
8MP0005257_abnormal_intraocular_pressure2.90609146
9MP0003880_abnormal_central_pattern2.88408019
10MP0002063_abnormal_learning/memory/cond2.86385204
11MP0004858_abnormal_nervous_system2.81901435
12MP0003566_abnormal_cell_adhesion2.62038752
13MP0003950_abnormal_plasma_membrane2.57592695
14MP0009745_abnormal_behavioral_response2.54987273
15MP0009046_muscle_twitch2.51218120
16MP0002064_seizures2.50779065
17MP0009780_abnormal_chondrocyte_physiolo2.39502029
18MP0010352_gastrointestinal_tract_polyps2.37949528
19MP0003329_amyloid_beta_deposits2.37497810
20MP0010368_abnormal_lymphatic_system2.30835986
21MP0002734_abnormal_mechanical_nocicepti2.23915696
22MP0002572_abnormal_emotion/affect_behav2.22534147
23MP0003283_abnormal_digestive_organ2.22277758
24MP0001486_abnormal_startle_reflex2.15032617
25MP0002822_catalepsy2.11536156
26MP0002909_abnormal_adrenal_gland2.06609020
27MP0001968_abnormal_touch/_nociception2.01525919
28MP0002272_abnormal_nervous_system1.99861121
29MP0000778_abnormal_nervous_system1.95308594
30MP0005423_abnormal_somatic_nervous1.93624177
31MP0005646_abnormal_pituitary_gland1.84716670
32MP0001348_abnormal_lacrimal_gland1.84346709
33MP0003091_abnormal_cell_migration1.83820417
34MP0002638_abnormal_pupillary_reflex1.83285876
35MP0000767_abnormal_smooth_muscle1.82816189
36MP0003122_maternal_imprinting1.76246858
37MP0005171_absent_coat_pigmentation1.71816650
38MP0008569_lethality_at_weaning1.70012909
39MP0000538_abnormal_urinary_bladder1.67800582
40MP0006054_spinal_hemorrhage1.67466173
41MP0002060_abnormal_skin_morphology1.67114224
42MP0004811_abnormal_neuron_physiology1.64594196
43MP0000955_abnormal_spinal_cord1.64447006
44MP0002557_abnormal_social/conspecific_i1.63433953
45MP0002184_abnormal_innervation1.62157538
46MP0001440_abnormal_grooming_behavior1.58430487
47MP0002067_abnormal_sensory_capabilities1.57956246
48MP0002733_abnormal_thermal_nociception1.57696078
49MP0005023_abnormal_wound_healing1.56566160
50MP0004885_abnormal_endolymph1.55745274
51MP0002295_abnormal_pulmonary_circulatio1.55462229
52MP0005508_abnormal_skeleton_morphology1.50424328
53MP0001984_abnormal_olfaction1.50315605
54MP0002735_abnormal_chemical_nociception1.49413050
55MP0002896_abnormal_bone_mineralization1.49379356
56MP0001970_abnormal_pain_threshold1.48561825
57MP0001502_abnormal_circadian_rhythm1.45892928
58MP0000569_abnormal_digit_pigmentation1.44271159
59MP0001299_abnormal_eye_distance/1.42023342
60MP0003942_abnormal_urinary_system1.40975249
61MP0000751_myopathy1.40833159
62MP0004233_abnormal_muscle_weight1.39514889
63MP0001542_abnormal_bone_strength1.38858547
64MP0005386_behavior/neurological_phenoty1.38305842
65MP0004924_abnormal_behavior1.38305842
66MP0005645_abnormal_hypothalamus_physiol1.37590721
67MP0001501_abnormal_sleep_pattern1.36159620
68MP0002882_abnormal_neuron_morphology1.35570886
69MP0009250_abnormal_appendicular_skeleto1.35120790
70MP0002736_abnormal_nociception_after1.34886095
71MP0000013_abnormal_adipose_tissue1.34312503
72MP0005248_abnormal_Harderian_gland1.31760435
73MP0004145_abnormal_muscle_electrophysio1.31737646
74MP0000733_abnormal_muscle_development1.30384243
75MP0005623_abnormal_meninges_morphology1.30352414
76MP0002090_abnormal_vision1.23108499
77MP0003690_abnormal_glial_cell1.22874994
78MP0003633_abnormal_nervous_system1.22584400
79MP0002066_abnormal_motor_capabilities/c1.22373760
80MP0002877_abnormal_melanocyte_morpholog1.22235366
81MP0005595_abnormal_vascular_smooth1.20572914
82MP0003941_abnormal_skin_development1.17693135
83MP0003137_abnormal_impulse_conducting1.17344565
84MP0003634_abnormal_glial_cell1.16328624
85MP0002152_abnormal_brain_morphology1.12067106
86MP0000762_abnormal_tongue_morphology1.09078503
87MP0003631_nervous_system_phenotype1.07906296
88MP0008961_abnormal_basal_metabolism1.07268243
89MP0001177_atelectasis1.04788180
90MP0004215_abnormal_myocardial_fiber1.04685725
91MP0003385_abnormal_body_wall1.04680601
92MP0009053_abnormal_anal_canal1.04362716
93MP0002089_abnormal_postnatal_growth/wei1.04314129
94MP0004084_abnormal_cardiac_muscle1.04037270
95MP0002837_dystrophic_cardiac_calcinosis1.02741320
96MP0001849_ear_inflammation1.02402080
97MP0006276_abnormal_autonomic_nervous1.02014336
98MP0003632_abnormal_nervous_system1.01736663
99MP0005551_abnormal_eye_electrophysiolog0.99969353
100MP0000604_amyloidosis0.99177549
101MP0005503_abnormal_tendon_morphology0.98410006
102MP0001661_extended_life_span0.98111484
103MP0002168_other_aberrant_phenotype0.97092140
104MP0004085_abnormal_heartbeat0.96998056
105MP0000759_abnormal_skeletal_muscle0.95069909
106MP0001879_abnormal_lymphatic_vessel0.94853347
107MP0000462_abnormal_digestive_system0.94244748
108MP0003879_abnormal_hair_cell0.93257006
109MP0000613_abnormal_salivary_gland0.93178861
110MP0003279_aneurysm0.92598917
111MP0003755_abnormal_palate_morphology0.92532197
112MP0000749_muscle_degeneration0.89452242
113MP0002254_reproductive_system_inflammat0.89072924
114MP0001243_abnormal_dermal_layer0.87926474
115MP0000534_abnormal_ureter_morphology0.87722804
116MP0006138_congestive_heart_failure0.86976658
117MP0003935_abnormal_craniofacial_develop0.85250393
118MP0000467_abnormal_esophagus_morphology0.82590497
119MP0000432_abnormal_head_morphology0.81968461
120MP0003787_abnormal_imprinting0.81403741
121MP0002069_abnormal_eating/drinking_beha0.80737392
122MP0008438_abnormal_cutaneous_collagen0.80666866
123MP0005197_abnormal_uvea_morphology0.80409438
124MP0005409_darkened_coat_color0.79413212
125MP0000163_abnormal_cartilage_morphology0.78596768
126MP0002751_abnormal_autonomic_nervous0.78549250
127MP0004036_abnormal_muscle_relaxation0.77923112
128MP0003183_abnormal_peptide_metabolism0.76881763
129MP0005187_abnormal_penis_morphology0.76865348
130MP0004142_abnormal_muscle_tone0.76817662
131MP0000920_abnormal_myelination0.76356560
132MP0010030_abnormal_orbit_morphology0.75647821
133MP0002108_abnormal_muscle_morphology0.75293165
134MP0002128_abnormal_blood_circulation0.74641742
135MP0002229_neurodegeneration0.74043427
136MP0004087_abnormal_muscle_fiber0.73720344
137MP0003115_abnormal_respiratory_system0.73619242
138MP0002115_abnormal_skeleton_extremities0.73538257
139MP0000428_abnormal_craniofacial_morphol0.73392927
140MP0002234_abnormal_pharynx_morphology0.72163310
141MP0000631_abnormal_neuroendocrine_gland0.72087582
142MP0003172_abnormal_lysosome_physiology0.71994677
143MP0005076_abnormal_cell_differentiation0.71426096
144MP0000427_abnormal_hair_cycle0.70045289
145MP0003045_fibrosis0.70026310
146MP0010386_abnormal_urinary_bladder0.69871584
147MP0003861_abnormal_nervous_system0.69795658
148MP0002752_abnormal_somatic_nervous0.68639887
149MP0009384_cardiac_valve_regurgitation0.68579808
150MP0002116_abnormal_craniofacial_bone0.68031006
151MP0004134_abnormal_chest_morphology0.67694068
152MP0000003_abnormal_adipose_tissue0.67595596
153MP0002653_abnormal_ependyma_morphology0.67555757
154MP0001529_abnormal_vocalization0.65340686
155MP0002114_abnormal_axial_skeleton0.64051464
156MP0005620_abnormal_muscle_contractility0.63904694
157MP0000516_abnormal_urinary_system0.63444224
158MP0005367_renal/urinary_system_phenotyp0.63444224
159MP0008775_abnormal_heart_ventricle0.63316130
160MP0002932_abnormal_joint_morphology0.63105656
161MP0005369_muscle_phenotype0.62596285
162MP0001175_abnormal_lung_morphology0.62585554
163MP0005394_taste/olfaction_phenotype0.62196461
164MP0005499_abnormal_olfactory_system0.62196461
165MP0005167_abnormal_blood-brain_barrier0.61304930
166MP0000579_abnormal_nail_morphology0.61149640
167MP0005164_abnormal_response_to0.59455081
168MP0010234_abnormal_vibrissa_follicle0.57054721
169MP0003300_gastrointestinal_ulcer0.56543249
170MP0002925_abnormal_cardiovascular_devel0.55910599

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.34699987
2Myokymia (HP:0002411)4.73092358
3Aortic aneurysm (HP:0004942)4.68048918
4Follicular hyperkeratosis (HP:0007502)4.57272229
5Aortic dissection (HP:0002647)4.53833211
6Focal motor seizures (HP:0011153)4.31108891
7Focal seizures (HP:0007359)3.97080020
8Ankle contracture (HP:0006466)3.95640665
9Neurofibrillary tangles (HP:0002185)3.90994984
10Supranuclear gaze palsy (HP:0000605)3.83048622
11Type 1 muscle fiber predominance (HP:0003803)3.81854218
12Atrophic scars (HP:0001075)3.81409859
13Epileptic encephalopathy (HP:0200134)3.76114003
14Megalencephaly (HP:0001355)3.72897948
15Soft skin (HP:0000977)3.57978384
16Cervical subluxation (HP:0003308)3.57288066
17Action tremor (HP:0002345)3.55142254
18Arterial tortuosity (HP:0005116)3.49374285
19Genu recurvatum (HP:0002816)3.49345000
20Spinal rigidity (HP:0003306)3.38087058
21Cerebral inclusion bodies (HP:0100314)3.37136815
22Abnormality of dentin (HP:0010299)3.29728669
23Polyphagia (HP:0002591)3.23594900
24Progressive cerebellar ataxia (HP:0002073)3.22918787
25Abnormal eating behavior (HP:0100738)3.15797632
26Slender build (HP:0001533)3.12444877
27Spondylolisthesis (HP:0003302)3.11763672
28Wormian bones (HP:0002645)3.11364136
29Ankle clonus (HP:0011448)3.01909856
30Visual hallucinations (HP:0002367)3.00122081
31Increased variability in muscle fiber diameter (HP:0003557)2.95026072
32Neonatal short-limb short stature (HP:0008921)2.91012578
33Fragile skin (HP:0001030)2.85582893
34Depression (HP:0000716)2.81582290
35Overgrowth (HP:0001548)2.74897163
36Genetic anticipation (HP:0003743)2.72349288
37Lymphangioma (HP:0100764)2.72071850
38Dysdiadochokinesis (HP:0002075)2.71386234
39Blue sclerae (HP:0000592)2.70645647
40Hemiparesis (HP:0001269)2.60705029
41Febrile seizures (HP:0002373)2.60590015
42Joint laxity (HP:0001388)2.56555642
43Shallow orbits (HP:0000586)2.56292906
44Hyperextensible skin (HP:0000974)2.54706608
45Buphthalmos (HP:0000557)2.54685826
46Wide anterior fontanel (HP:0000260)2.54679422
47Mutism (HP:0002300)2.50140626
48Truncal ataxia (HP:0002078)2.49035493
49Pheochromocytoma (HP:0002666)2.48969713
50Mildly elevated creatine phosphokinase (HP:0008180)2.48780512
51Hypoplasia of the iris (HP:0007676)2.46180319
52Congenital glaucoma (HP:0001087)2.43100152
53Aneurysm (HP:0002617)2.41963625
54Atonic seizures (HP:0010819)2.41187766
55Abnormality of skeletal muscle fiber size (HP:0012084)2.40441803
56Biconcave vertebral bodies (HP:0004586)2.40148949
57Mitral valve prolapse (HP:0001634)2.37360467
58Torticollis (HP:0000473)2.35626312
59Broad-based gait (HP:0002136)2.34503871
60Postural instability (HP:0002172)2.33089568
61Dilatation of the ascending aorta (HP:0005111)2.32241146
62Generalized tonic-clonic seizures (HP:0002069)2.31899177
63Aplasia involving bones of the extremities (HP:0009825)2.31657604
64Aplasia involving bones of the upper limbs (HP:0009823)2.31657604
65Aplasia of the phalanges of the hand (HP:0009802)2.31657604
66Aortic regurgitation (HP:0001659)2.30405717
67Insomnia (HP:0100785)2.30006002
68Cerebral aneurysm (HP:0004944)2.28189196
69Coronal craniosynostosis (HP:0004440)2.27973043
70Anxiety (HP:0000739)2.27747791
71Urinary bladder sphincter dysfunction (HP:0002839)2.27401949
72Absence seizures (HP:0002121)2.27213378
73Dysmetria (HP:0001310)2.25772420
74EEG with generalized epileptiform discharges (HP:0011198)2.24165526
75Impaired vibration sensation in the lower limbs (HP:0002166)2.23952006
76Hypsarrhythmia (HP:0002521)2.23231607
77Elbow flexion contracture (HP:0002987)2.22742169
78Epileptiform EEG discharges (HP:0011182)2.21411545
79Intention tremor (HP:0002080)2.21408636
80Hemiplegia (HP:0002301)2.21197982
81Broad metatarsal (HP:0001783)2.20581943
82Mild short stature (HP:0003502)2.20437445
83Papilledema (HP:0001085)2.19372057
84Abnormality of binocular vision (HP:0011514)2.17462174
85Diplopia (HP:0000651)2.17462174
86Osteolytic defects of the hand bones (HP:0009699)2.16141232
87Osteolytic defects of the phalanges of the hand (HP:0009771)2.16141232
88Narrow nasal bridge (HP:0000446)2.15420583
89Poor eye contact (HP:0000817)2.14255264
90Neoplasm of the heart (HP:0100544)2.13349851
91Dialeptic seizures (HP:0011146)2.11148177
92Stereotypic behavior (HP:0000733)2.10754511
93Natal tooth (HP:0000695)2.10494041
94Gaze-evoked nystagmus (HP:0000640)2.08026371
95Spastic gait (HP:0002064)2.06832880
96Ventricular fibrillation (HP:0001663)2.04488084
97Asymmetry of the thorax (HP:0001555)2.02800850
98Long toe (HP:0010511)2.02558505
99Macroorchidism (HP:0000053)2.02348559
100Agitation (HP:0000713)2.01299891
101Impaired smooth pursuit (HP:0007772)2.01229093
102Vertebral compression fractures (HP:0002953)2.01185364
103Prolonged QT interval (HP:0001657)1.99798287
104Infantile muscular hypotonia (HP:0008947)1.99765295
105Mitral regurgitation (HP:0001653)1.99151035
106Abnormality of the anterior chamber (HP:0000593)1.98986631
107Urinary urgency (HP:0000012)1.98962762
108Impaired social interactions (HP:0000735)1.98061680
109Abnormal social behavior (HP:0012433)1.98061680
110Pointed chin (HP:0000307)1.95778510
111Neuroendocrine neoplasm (HP:0100634)1.95496206
112Protrusio acetabuli (HP:0003179)1.95400767
113Protruding ear (HP:0000411)1.95237076
114Complete atrioventricular canal defect (HP:0001674)1.93993938
115Focal dystonia (HP:0004373)1.93847230
116Cutaneous melanoma (HP:0012056)1.93554628
117Lower limb muscle weakness (HP:0007340)1.93079719
118Aqueductal stenosis (HP:0002410)1.92213197
119Mitral stenosis (HP:0001718)1.91946563
120Peritonitis (HP:0002586)1.91880908
121Broad face (HP:0000283)1.91417729
122Drooling (HP:0002307)1.91325163
123Excessive salivation (HP:0003781)1.91325163
124Abnormality of the acetabulum (HP:0003170)1.91011901
125Abnormal EKG (HP:0003115)1.89060309
126Narrow palate (HP:0000189)1.88817305
127Upper limb amyotrophy (HP:0009129)1.88795543
128Distal upper limb amyotrophy (HP:0007149)1.88795543
129Insidious onset (HP:0003587)1.88772935
130Termporal pattern (HP:0011008)1.88772935
131Aortic valve stenosis (HP:0001650)1.88320823
132Apathy (HP:0000741)1.86759558
133Limited hip movement (HP:0008800)1.86411239
134Hallux valgus (HP:0001822)1.85542659
135Abnormality of ocular smooth pursuit (HP:0000617)1.85297988
136Increased number of teeth (HP:0011069)1.84254554
137Deviation of the hallux (HP:0010051)1.84072088
138Cardiovascular calcification (HP:0011915)1.83239949
139Obstructive sleep apnea (HP:0002870)1.83207641
140Short nail (HP:0001799)1.82809643
141Ulnar bowing (HP:0003031)1.81666438
142Amyotrophic lateral sclerosis (HP:0007354)1.81582587
143Renal duplication (HP:0000075)1.81101799
144Limb dystonia (HP:0002451)1.80683421
145Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.79936670
146Turricephaly (HP:0000262)1.79686884
147Dysmetric saccades (HP:0000641)1.79396780
148Hypoventilation (HP:0002791)1.77962862
149Open mouth (HP:0000194)1.77894279
150Bowel diverticulosis (HP:0005222)1.76596337
151Gingival overgrowth (HP:0000212)1.76249524
152Disproportionate tall stature (HP:0001519)1.76167244
153Delayed gross motor development (HP:0002194)1.75729529
154Diminished motivation (HP:0000745)1.75714603
155Bradykinesia (HP:0002067)1.75322125
156Scanning speech (HP:0002168)1.74938309
157Wrist flexion contracture (HP:0001239)1.74560537
158Neuronal loss in central nervous system (HP:0002529)1.73333688
159Atrioventricular canal defect (HP:0006695)1.73146004
160Hyperacusis (HP:0010780)1.72571554
161Primary atrial arrhythmia (HP:0001692)1.72442887
162Round ear (HP:0100830)1.71450793
163Bradycardia (HP:0001662)1.71212389
164Bladder diverticulum (HP:0000015)1.70911846
165Atrial fibrillation (HP:0005110)1.70648190
166Hypoplasia of the odontoid process (HP:0003311)1.70598028
167Lower limb amyotrophy (HP:0007210)1.70490281
168Craniofacial dystonia (HP:0012179)1.70474168
169Elfin facies (HP:0004428)1.70212241
170Ectopia lentis (HP:0001083)1.70158366
171Absent frontal sinuses (HP:0002688)1.69868110
172Broad ribs (HP:0000885)1.69099550
173Abnormality of the corticospinal tract (HP:0002492)1.68397072
174Knee flexion contracture (HP:0006380)1.67753784
175Nuclear cataract (HP:0100018)1.67753606
176Entropion (HP:0000621)1.67103675
177Abnormality of the odontoid process (HP:0003310)1.67011360
178Flat cornea (HP:0007720)1.65751508
179Hip contracture (HP:0003273)1.65237000
180Inguinal hernia (HP:0000023)1.65187181
181Venous abnormality (HP:0002624)1.65073279
182Scotoma (HP:0000575)1.64946118
183Hyperventilation (HP:0002883)1.64853914
184Vascular tortuosity (HP:0004948)1.64739520
185Limb-girdle muscle weakness (HP:0003325)1.64088363
186Hand muscle atrophy (HP:0009130)1.63966091
187Abnormal delivery (HP:0001787)1.63090532
188Abnormality of the lower motor neuron (HP:0002366)1.62843426
189Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.62751808
190Camptodactyly of toe (HP:0001836)1.62744542
191Short clavicles (HP:0000894)1.62192174

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.81212624
2MYLK3.77410633
3MARK13.70728419
4FRK3.45763883
5NTRK23.27147140
6NTRK33.22181527
7EPHA43.18158574
8PTK23.03635777
9TNIK2.90792944
10AKT32.86038295
11TTN2.42046092
12PAK62.29019794
13PRKD32.28425860
14MINK12.27909952
15NEK92.21597943
16PAK22.11589472
17MAP3K42.03948308
18DAPK22.00806831
19PHKG21.94636860
20PHKG11.94636860
21CAMKK11.88613350
22KSR11.83755252
23MET1.70695656
24KSR21.67645675
25NTRK11.66043725
26ERBB41.63987241
27LMTK21.62396267
28MAP2K71.56293221
29CDK51.55802942
30CAMKK21.53620734
31LIMK11.52894293
32PKN21.50766631
33RIPK11.49736819
34STK31.47906747
35MST41.44747784
36ICK1.44173314
37PNCK1.42200949
38PAK31.39300629
39PDGFRA1.35539693
40LATS21.34943020
41FLT31.28824680
42MAPK131.28777930
43LATS11.28062729
44PRKD21.27768245
45PDGFRB1.25746748
46TGFBR21.24447845
47UHMK11.22492846
48PRKCG1.20139942
49TRPM71.17510646
50TYRO31.17465944
51CASK1.15078941
52MAP2K41.13690448
53FGFR21.13645639
54TESK11.12976197
55PIK3CA1.11453025
56CAMK1G1.05981784
57SIK21.05743109
58CDK181.04639472
59CDK151.03925075
60CDK121.03655153
61SGK2231.02572417
62SGK4941.02572417
63PRKCH1.02256767
64PLK20.99653831
65CDK140.99592952
66DDR20.97095105
67MTOR0.96210674
68STK380.94264483
69STK40.94214559
70MST1R0.93935633
71CDK11A0.88932833
72RET0.88315801
73MAP3K20.87531829
74EPHA30.87161937
75PRPF4B0.86303396
76STK38L0.83121447
77DMPK0.82621020
78FGFR30.80937734
79NEK60.79424049
80MAP3K60.79383505
81MAPK70.79248131
82SGK30.78707779
83SGK20.77725482
84CDC42BPA0.77452600
85EPHB20.76425625
86EPHB10.76332719
87NEK10.74935678
88CDK190.74399960
89DAPK10.73562677
90CAMK1D0.73196399
91MAP3K130.72902549
92DYRK1A0.71888663
93GRK10.71807413
94WNK10.71768551
95MARK20.71684022
96TRIB30.69559736
97CAMK2A0.68482795
98GSK3A0.67531481
99INSRR0.66629808
100CAMK10.65791932
101ARAF0.63920210
102SGK10.63273709
103FER0.62687253
104ERBB30.62467306
105SIK10.62368054
106MELK0.61831531
107STK110.58489230
108PAK40.57631545
109MAP2K60.57094436
110PIK3CG0.56569903
111CAMK40.55683465
112FYN0.54371428
113ROCK10.54172260
114PRKCE0.53870082
115PRKCZ0.53348653
116ALK0.50947198
117FES0.50887589
118EPHA20.50738559
119ERBB20.50482623
120PRKD10.50186449
121TAOK10.50064161
122GRK70.49983308
123IRAK20.49941898
124BMX0.49741123
125CAMK2G0.49727538
126RPS6KA30.49168332
127MAP2K10.48941938
128ROCK20.48733865
129ABL20.47411318
130SIK30.47170054
131DYRK1B0.46923488
132PRKG20.45876847
133PIM20.45722854
134JAK10.44316358
135PTK2B0.44301750
136MAP3K70.43970804
137FGFR10.43297555
138RPS6KA20.42346076
139CAMK2B0.42180239
140ILK0.42150524
141NLK0.41943629
142CSNK1G20.41876114
143RIPK40.41722841
144GRK50.41684161
145FGR0.40721178
146CAMK2D0.40664015
147SCYL20.40405234
148PDK20.39771487
149DYRK20.39453916
150EEF2K0.39351740
151ADRBK10.39328925
152BRD40.38153361
153FGFR40.38039172
154EIF2AK30.37487714
155PKN10.37371343
156STK100.32656905

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.51683653
2Nicotine addiction_Homo sapiens_hsa050332.70289654
3Synaptic vesicle cycle_Homo sapiens_hsa047212.66520865
4Circadian entrainment_Homo sapiens_hsa047132.48533503
5Olfactory transduction_Homo sapiens_hsa047402.45124436
6GABAergic synapse_Homo sapiens_hsa047272.33038412
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22188874
8Glutamatergic synapse_Homo sapiens_hsa047242.19207844
9Insulin secretion_Homo sapiens_hsa049112.14439706
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.12338968
11Morphine addiction_Homo sapiens_hsa050322.11067037
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.10816289
13Long-term potentiation_Homo sapiens_hsa047202.02506712
14Amphetamine addiction_Homo sapiens_hsa050311.90212258
15Dopaminergic synapse_Homo sapiens_hsa047281.87743859
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.77199579
17Salivary secretion_Homo sapiens_hsa049701.76058987
18Cholinergic synapse_Homo sapiens_hsa047251.74395520
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73140845
20Gastric acid secretion_Homo sapiens_hsa049711.70544940
21Cocaine addiction_Homo sapiens_hsa050301.61054271
22Regulation of actin cytoskeleton_Homo sapiens_hsa048101.56468787
23Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.55432983
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51518336
25Protein digestion and absorption_Homo sapiens_hsa049741.48033570
26Renin secretion_Homo sapiens_hsa049241.47817065
27Adherens junction_Homo sapiens_hsa045201.45051356
28Dilated cardiomyopathy_Homo sapiens_hsa054141.41111859
29Axon guidance_Homo sapiens_hsa043601.38836072
30Oxytocin signaling pathway_Homo sapiens_hsa049211.38531543
31Gap junction_Homo sapiens_hsa045401.38021173
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.37931003
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.36555704
34Calcium signaling pathway_Homo sapiens_hsa040201.34642329
35Amoebiasis_Homo sapiens_hsa051461.33251148
36Type II diabetes mellitus_Homo sapiens_hsa049301.33207379
37cAMP signaling pathway_Homo sapiens_hsa040241.30767775
38PI3K-Akt signaling pathway_Homo sapiens_hsa041511.29424012
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29138003
40MicroRNAs in cancer_Homo sapiens_hsa052061.28605976
41Long-term depression_Homo sapiens_hsa047301.26703770
42Serotonergic synapse_Homo sapiens_hsa047261.26194064
43Tight junction_Homo sapiens_hsa045301.23623868
44GnRH signaling pathway_Homo sapiens_hsa049121.23060180
45Taste transduction_Homo sapiens_hsa047421.22915789
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21738406
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.21166666
48Small cell lung cancer_Homo sapiens_hsa052221.18401581
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.18090371
50TGF-beta signaling pathway_Homo sapiens_hsa043501.17300630
51Glioma_Homo sapiens_hsa052141.13343461
52Nitrogen metabolism_Homo sapiens_hsa009101.12049511
53cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08431868
54Melanogenesis_Homo sapiens_hsa049161.06461288
55Sphingolipid metabolism_Homo sapiens_hsa006001.05864581
56Estrogen signaling pathway_Homo sapiens_hsa049151.03638411
57ErbB signaling pathway_Homo sapiens_hsa040121.03299334
58Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.01629043
59Other glycan degradation_Homo sapiens_hsa005111.01552038
60N-Glycan biosynthesis_Homo sapiens_hsa005101.00613797
61Pathways in cancer_Homo sapiens_hsa052001.00498826
62Circadian rhythm_Homo sapiens_hsa047100.99636089
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.99520497
64Prostate cancer_Homo sapiens_hsa052150.97833631
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.94667112
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92811443
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92173738
68Bladder cancer_Homo sapiens_hsa052190.90621884
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.88280659
70Chronic myeloid leukemia_Homo sapiens_hsa052200.85115435
71Thyroid hormone synthesis_Homo sapiens_hsa049180.84113630
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.83821082
73Lysine degradation_Homo sapiens_hsa003100.83196713
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82998250
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82807528
76Vitamin B6 metabolism_Homo sapiens_hsa007500.81722459
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80918508
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80831608
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.80533087
80Dorso-ventral axis formation_Homo sapiens_hsa043200.78346314
81Cardiac muscle contraction_Homo sapiens_hsa042600.77715784
82Choline metabolism in cancer_Homo sapiens_hsa052310.74400451
83mTOR signaling pathway_Homo sapiens_hsa041500.73299123
84Pancreatic secretion_Homo sapiens_hsa049720.72298107
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71140095
86Renal cell carcinoma_Homo sapiens_hsa052110.71091471
87Wnt signaling pathway_Homo sapiens_hsa043100.69546324
88MAPK signaling pathway_Homo sapiens_hsa040100.69308237
89Rap1 signaling pathway_Homo sapiens_hsa040150.69180609
90Glucagon signaling pathway_Homo sapiens_hsa049220.66588182
91Vibrio cholerae infection_Homo sapiens_hsa051100.66547454
92Endometrial cancer_Homo sapiens_hsa052130.66372784
93Phototransduction_Homo sapiens_hsa047440.64888276
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64797653
95AMPK signaling pathway_Homo sapiens_hsa041520.64405311
96Oocyte meiosis_Homo sapiens_hsa041140.64062045
97Hedgehog signaling pathway_Homo sapiens_hsa043400.62947412
98Ras signaling pathway_Homo sapiens_hsa040140.62514007
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62388587
100Bile secretion_Homo sapiens_hsa049760.61495093
101Fatty acid biosynthesis_Homo sapiens_hsa000610.61242633
102Insulin signaling pathway_Homo sapiens_hsa049100.60654242
103Endocytosis_Homo sapiens_hsa041440.60380519
104Complement and coagulation cascades_Homo sapiens_hsa046100.60355689
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.59438933
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.59167495
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56894812
108ABC transporters_Homo sapiens_hsa020100.56869751
109Platelet activation_Homo sapiens_hsa046110.56755514
110Prion diseases_Homo sapiens_hsa050200.56540242
111Thyroid cancer_Homo sapiens_hsa052160.56438377
112Proteoglycans in cancer_Homo sapiens_hsa052050.54552361
113FoxO signaling pathway_Homo sapiens_hsa040680.53925794
114Hippo signaling pathway_Homo sapiens_hsa043900.53832214
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53790075
116Colorectal cancer_Homo sapiens_hsa052100.53615380
117Collecting duct acid secretion_Homo sapiens_hsa049660.53594633
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53521749
119Basal cell carcinoma_Homo sapiens_hsa052170.50088900
120Alcoholism_Homo sapiens_hsa050340.49669092
121VEGF signaling pathway_Homo sapiens_hsa043700.49238095
122Focal adhesion_Homo sapiens_hsa045100.47045695
123Ovarian steroidogenesis_Homo sapiens_hsa049130.46603874
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42688422
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42117144
126Type I diabetes mellitus_Homo sapiens_hsa049400.41847633
127Mineral absorption_Homo sapiens_hsa049780.41831851
128Non-small cell lung cancer_Homo sapiens_hsa052230.40616587
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.40440764
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36952001
131Melanoma_Homo sapiens_hsa052180.36925930
132Inositol phosphate metabolism_Homo sapiens_hsa005620.35619675

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