PCDHGA8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)5.49716858
2vocalization behavior (GO:0071625)5.28300264
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.27888881
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.15923504
5neuron cell-cell adhesion (GO:0007158)5.05403622
6behavioral response to nicotine (GO:0035095)5.03372677
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.96488705
8postsynaptic membrane organization (GO:0001941)4.82364407
9protein localization to synapse (GO:0035418)4.73193760
10synaptic vesicle maturation (GO:0016188)4.70845570
11synaptic vesicle exocytosis (GO:0016079)4.65145518
12regulation of glutamate receptor signaling pathway (GO:1900449)4.61225363
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.41864209
14regulation of synaptic vesicle exocytosis (GO:2000300)4.33036568
15glutamate secretion (GO:0014047)4.32894458
16exploration behavior (GO:0035640)4.32084572
17fucose catabolic process (GO:0019317)4.30154224
18L-fucose metabolic process (GO:0042354)4.30154224
19L-fucose catabolic process (GO:0042355)4.30154224
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.28835209
21presynaptic membrane assembly (GO:0097105)4.20887263
22neurotransmitter-gated ion channel clustering (GO:0072578)4.11049300
23tryptophan catabolic process (GO:0006569)4.01848615
24indole-containing compound catabolic process (GO:0042436)4.01848615
25indolalkylamine catabolic process (GO:0046218)4.01848615
26synaptic vesicle docking involved in exocytosis (GO:0016081)3.93049643
27synaptic transmission, glutamatergic (GO:0035249)3.92963009
28glutamate receptor signaling pathway (GO:0007215)3.89934338
29indolalkylamine metabolic process (GO:0006586)3.86342611
30kynurenine metabolic process (GO:0070189)3.85659411
31neuronal action potential propagation (GO:0019227)3.83585350
32presynaptic membrane organization (GO:0097090)3.83501967
33neurotransmitter secretion (GO:0007269)3.80659259
34regulation of synaptic vesicle transport (GO:1902803)3.77643630
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.76862378
36layer formation in cerebral cortex (GO:0021819)3.76790287
37regulation of long-term neuronal synaptic plasticity (GO:0048169)3.76410705
38regulation of neuronal synaptic plasticity (GO:0048168)3.76387055
39neuron recognition (GO:0008038)3.73042958
40regulation of synapse structural plasticity (GO:0051823)3.70468297
41dendritic spine morphogenesis (GO:0060997)3.68909156
42water-soluble vitamin biosynthetic process (GO:0042364)3.68075376
43positive regulation of synaptic transmission, GABAergic (GO:0032230)3.65352046
44epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.64630019
45detection of light stimulus involved in sensory perception (GO:0050962)3.62563793
46detection of light stimulus involved in visual perception (GO:0050908)3.62563793
47neuron-neuron synaptic transmission (GO:0007270)3.61902234
48piRNA metabolic process (GO:0034587)3.57648083
49tryptophan metabolic process (GO:0006568)3.54264671
50positive regulation of synapse maturation (GO:0090129)3.54127755
51platelet dense granule organization (GO:0060155)3.53406724
52cellular ketone body metabolic process (GO:0046950)3.53250110
53long-term synaptic potentiation (GO:0060291)3.49391549
54auditory behavior (GO:0031223)3.49066776
55positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.47475723
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.45721305
57axonal fasciculation (GO:0007413)3.43969905
58gamma-aminobutyric acid transport (GO:0015812)3.43925604
59long-term memory (GO:0007616)3.40500255
60startle response (GO:0001964)3.38322488
61neural tube formation (GO:0001841)3.37990441
62DNA deamination (GO:0045006)3.37424262
63regulation of excitatory postsynaptic membrane potential (GO:0060079)3.36536377
64membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.36168598
65detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.35888817
66positive regulation of membrane potential (GO:0045838)3.33936039
67regulation of action potential (GO:0098900)3.33116682
68regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.31241712
69transmission of nerve impulse (GO:0019226)3.29270659
70positive regulation of synapse assembly (GO:0051965)3.29240706
71proline transport (GO:0015824)3.27427161
72regulation of synaptic transmission, glutamatergic (GO:0051966)3.23671238
73gamma-aminobutyric acid signaling pathway (GO:0007214)3.23321765
74response to auditory stimulus (GO:0010996)3.21836549
75axoneme assembly (GO:0035082)3.20627361
76regulation of synaptic plasticity (GO:0048167)3.20163042
77neurotransmitter transport (GO:0006836)3.20107128
78synaptic vesicle endocytosis (GO:0048488)3.19833880
79synapse assembly (GO:0007416)3.19204208
80epithelial cilium movement (GO:0003351)3.19062467
81regulation of postsynaptic membrane potential (GO:0060078)3.18655360
82ketone body metabolic process (GO:1902224)3.18601135
83regulation of dendritic spine morphogenesis (GO:0061001)3.17845008
84cellular potassium ion homeostasis (GO:0030007)3.17169051
85dendrite morphogenesis (GO:0048813)3.16312918
86G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.15486101
87protein K11-linked deubiquitination (GO:0035871)3.13469704
88negative regulation of mast cell activation (GO:0033004)3.13085165
89cerebellar granule cell differentiation (GO:0021707)3.12246712
90negative regulation of synaptic transmission, GABAergic (GO:0032229)3.10970873
91negative regulation of cytosolic calcium ion concentration (GO:0051481)3.09588464
92regulation of cilium movement (GO:0003352)3.07313728
93regulation of neurotransmitter secretion (GO:0046928)3.04047868
94regulation of vesicle fusion (GO:0031338)3.03805481
95DNA methylation involved in gamete generation (GO:0043046)3.03267408
96behavioral response to ethanol (GO:0048149)3.02712623
97innervation (GO:0060384)3.01683125
98retinal cone cell development (GO:0046549)3.01026808
99preassembly of GPI anchor in ER membrane (GO:0016254)2.98860733
100response to pheromone (GO:0019236)2.98723915
101activation of protein kinase A activity (GO:0034199)2.96615172
102neuronal ion channel clustering (GO:0045161)2.96508487
103cilium morphogenesis (GO:0060271)2.95009039
104protein polyglutamylation (GO:0018095)2.94514186
105cellular biogenic amine catabolic process (GO:0042402)2.94104340
106amine catabolic process (GO:0009310)2.94104340
107regulation of synapse maturation (GO:0090128)2.93493652
108negative regulation of telomere maintenance (GO:0032205)2.91775483
109regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.91493248
110neuromuscular process controlling balance (GO:0050885)2.90722503
111neuronal action potential (GO:0019228)2.90479747
112mechanosensory behavior (GO:0007638)2.90162396
113membrane hyperpolarization (GO:0060081)2.89953020
114cell communication by electrical coupling (GO:0010644)2.89906754
115learning (GO:0007612)2.89346206
116cell migration in hindbrain (GO:0021535)2.89317859
117synapse organization (GO:0050808)2.86299595
118regulation of glucokinase activity (GO:0033131)2.86111577
119regulation of hexokinase activity (GO:1903299)2.86111577
120regulation of neurotransmitter transport (GO:0051588)2.86043238
121positive regulation of synaptic transmission (GO:0050806)2.85298257
122indole-containing compound metabolic process (GO:0042430)2.85012123
123regulation of respiratory system process (GO:0044065)2.84280131
124positive regulation of dendritic spine development (GO:0060999)2.83789836
125photoreceptor cell maintenance (GO:0045494)2.82134441
126regulation of neurotransmitter levels (GO:0001505)2.81824482
127respiratory chain complex IV assembly (GO:0008535)2.79783273
128cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.77503636
129regulation of synaptic transmission (GO:0050804)2.77221654
130regulation of synaptic transmission, GABAergic (GO:0032228)2.76892949
131dendritic spine organization (GO:0097061)2.76755816
132dopamine transport (GO:0015872)2.76542920
133protein complex biogenesis (GO:0070271)2.76252141
134membrane depolarization (GO:0051899)2.75725332
135cerebellar Purkinje cell differentiation (GO:0021702)2.74743405
136positive regulation of dendritic spine morphogenesis (GO:0061003)2.74540481
137regulation of dendritic spine development (GO:0060998)2.73110176
138reflex (GO:0060004)2.72970804
139regulation of sarcomere organization (GO:0060297)2.72825533
140regulation of synapse assembly (GO:0051963)2.72723375
141L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.70221552
142central nervous system projection neuron axonogenesis (GO:0021952)2.69649661
143behavioral defense response (GO:0002209)2.69563408
144behavioral fear response (GO:0001662)2.69563408
145prepulse inhibition (GO:0060134)2.69232572
146mitochondrial respiratory chain complex I assembly (GO:0032981)2.68704494
147NADH dehydrogenase complex assembly (GO:0010257)2.68704494
148mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.68704494
149positive regulation of neurotransmitter secretion (GO:0001956)2.68131869
150neuromuscular process (GO:0050905)2.67928276
151glycine transport (GO:0015816)2.67797629
152kidney morphogenesis (GO:0060993)2.67598249
153protein localization to cilium (GO:0061512)2.67249280
154regulation of memory T cell differentiation (GO:0043380)2.66116487
155cilium movement (GO:0003341)2.65827494
156cilium organization (GO:0044782)2.65470155
157S-adenosylmethionine metabolic process (GO:0046500)2.63642890
158cornea development in camera-type eye (GO:0061303)2.63170910
159peptidyl-histidine modification (GO:0018202)2.62674685
160adaptation of signaling pathway (GO:0023058)2.62346040
161regulation of hippo signaling (GO:0035330)2.61543362
162positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.61067771
163photoreceptor cell development (GO:0042461)2.60568923
164synaptic transmission, cholinergic (GO:0007271)2.59993246
165multicellular organism reproduction (GO:0032504)2.58315169
166sulfation (GO:0051923)2.57748872
167cilium assembly (GO:0042384)2.56918099
168regulation of neurotransmitter uptake (GO:0051580)2.56802140
169auditory receptor cell stereocilium organization (GO:0060088)2.53326736
170RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.52338614
171nonmotile primary cilium assembly (GO:0035058)2.51005972
172inner ear receptor stereocilium organization (GO:0060122)2.49345828
173glycerophospholipid catabolic process (GO:0046475)2.49071722
174establishment of protein localization to Golgi (GO:0072600)2.49031086
175phosphatidylinositol acyl-chain remodeling (GO:0036149)2.48829429
176mitochondrial respiratory chain complex assembly (GO:0033108)2.48801098
177aromatic amino acid family catabolic process (GO:0009074)2.47957877
178L-methionine salvage (GO:0071267)2.47524018
179L-methionine biosynthetic process (GO:0071265)2.47524018
180amino acid salvage (GO:0043102)2.47524018
181tachykinin receptor signaling pathway (GO:0007217)2.46862519
182mannosylation (GO:0097502)2.46738139
183cAMP catabolic process (GO:0006198)2.46164904
184cytochrome complex assembly (GO:0017004)2.45585006
185reciprocal DNA recombination (GO:0035825)2.44482147
186reciprocal meiotic recombination (GO:0007131)2.44482147
187primary amino compound metabolic process (GO:1901160)2.41376044
188cilium or flagellum-dependent cell motility (GO:0001539)2.40060373
189negative regulation of translation, ncRNA-mediated (GO:0040033)2.39882161
190regulation of translation, ncRNA-mediated (GO:0045974)2.39882161
191negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.39882161
192ubiquinone biosynthetic process (GO:0006744)2.39544670
193anterograde synaptic vesicle transport (GO:0048490)2.36750224
194regulation of rhodopsin mediated signaling pathway (GO:0022400)2.36363148
195regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.36289642
196cyclic nucleotide catabolic process (GO:0009214)2.36131202

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.37211035
2GBX2_23144817_ChIP-Seq_PC3_Human3.32631628
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.25552124
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.24710245
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.23833485
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.95105809
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.95105809
8* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.94035527
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.88367775
10* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.83239932
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.80093340
12* EED_16625203_ChIP-ChIP_MESCs_Mouse2.78894927
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.75120161
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.56345847
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.53370306
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.49915461
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.45960974
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.41245884
19REST_21632747_ChIP-Seq_MESCs_Mouse2.40515340
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.38662244
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.38380055
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.31971580
23DROSHA_22980978_ChIP-Seq_HELA_Human2.18319913
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.11301298
25RARB_27405468_Chip-Seq_BRAIN_Mouse2.09789490
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.01983017
27EWS_26573619_Chip-Seq_HEK293_Human2.00194567
28AR_21572438_ChIP-Seq_LNCaP_Human2.00143977
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.99248570
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97237685
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.97113080
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94124667
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.91306883
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.83712013
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81490150
36* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.79401542
37BCAT_22108803_ChIP-Seq_LS180_Human1.69563395
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65866441
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.64856867
40CBP_20019798_ChIP-Seq_JUKART_Human1.64856867
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64533558
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63272662
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62771224
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62335479
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.58098467
46* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57317060
47* RING1B_27294783_Chip-Seq_ESCs_Mouse1.56477597
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56054303
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54948214
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52110415
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51474779
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50260562
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47846671
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.45261499
55IRF1_19129219_ChIP-ChIP_H3396_Human1.43433952
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.42386361
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41549505
58TP53_22573176_ChIP-Seq_HFKS_Human1.40824816
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.40271978
60SMAD4_21799915_ChIP-Seq_A2780_Human1.39054995
61RING1B_27294783_Chip-Seq_NPCs_Mouse1.38931335
62NANOG_19829295_ChIP-Seq_ESCs_Human1.38859964
63SOX2_19829295_ChIP-Seq_ESCs_Human1.38859964
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38584070
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37808414
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37808414
67TAF15_26573619_Chip-Seq_HEK293_Human1.35089155
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34195350
69TCF4_22108803_ChIP-Seq_LS180_Human1.34096618
70RNF2_27304074_Chip-Seq_NSC_Mouse1.33539828
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32294408
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30905277
73ZNF274_21170338_ChIP-Seq_K562_Hela1.30146669
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26685561
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26309292
76P300_19829295_ChIP-Seq_ESCs_Human1.25527039
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25115856
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24108496
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23415063
80TP53_20018659_ChIP-ChIP_R1E_Mouse1.22877021
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.22326437
82CRX_20693478_ChIP-Seq_RETINA_Mouse1.21928693
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21643885
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21399696
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.21342373
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21281069
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20737273
88SMAD4_21741376_ChIP-Seq_EPCs_Human1.19999581
89FOXA1_25329375_ChIP-Seq_VCAP_Human1.19849286
90FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19849286
91FLI1_21867929_ChIP-Seq_TH2_Mouse1.19573211
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19363387
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.19199203
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.18109894
95ETV2_25802403_ChIP-Seq_MESCs_Mouse1.17744987
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17358167
97P53_22387025_ChIP-Seq_ESCs_Mouse1.17173134
98CDX2_22108803_ChIP-Seq_LS180_Human1.15944724
99TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15873553
100P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14729276
101TP53_16413492_ChIP-PET_HCT116_Human1.14226347
102SOX2_21211035_ChIP-Seq_LN229_Gbm1.13673508
103TRIM28_21343339_ChIP-Seq_HEK293_Human1.13526456
104FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12801193
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12724397
106RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12455448
107ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11502856
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11228590
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10697913
110WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10667896
111DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08913889
112MYC_18940864_ChIP-ChIP_HL60_Human1.08090535
113NCOR_22424771_ChIP-Seq_293T_Human1.08071800
114AR_19668381_ChIP-Seq_PC3_Human1.07277206
115NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07136462
116AR_25329375_ChIP-Seq_VCAP_Human1.07002115
117AR_20517297_ChIP-Seq_VCAP_Human1.06900573
118E2F1_18555785_Chip-Seq_ESCs_Mouse1.06408137
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06018157
120STAT3_18555785_Chip-Seq_ESCs_Mouse1.05819808
121WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05735082
122GATA3_21878914_ChIP-Seq_MCF-7_Human1.05119090
123SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04732254
124HOXB7_26014856_ChIP-Seq_BT474_Human1.04193591
125OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02447949
126EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00905989
127STAT3_23295773_ChIP-Seq_U87_Human1.00453173
128SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99025195
129TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97596901
130HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96954729
131CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96348908
132YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95902711
133KDM2B_26808549_Chip-Seq_K562_Human0.95030499
134ARNT_22903824_ChIP-Seq_MCF-7_Human0.94417011
135TP53_18474530_ChIP-ChIP_U2OS_Human0.94391351
136MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93914376
137ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92930136
138RUNX2_22187159_ChIP-Seq_PCA_Human0.91857978
139VDR_22108803_ChIP-Seq_LS180_Human0.91660970
140TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91097023
141SMAD4_21741376_ChIP-Seq_HESCs_Human0.90289094
142SMAD3_21741376_ChIP-Seq_ESCs_Human0.89799173
143CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89330883
144TCF4_23295773_ChIP-Seq_U87_Human0.89073567
145OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88735660
146SMAD3_21741376_ChIP-Seq_HESCs_Human0.87975307
147AHR_22903824_ChIP-Seq_MCF-7_Human0.87905169
148SMAD_19615063_ChIP-ChIP_OVARY_Human0.87465019
149IGF1R_20145208_ChIP-Seq_DFB_Human0.87338793
150TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86864377
151UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86548782
152NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86176806
153CTCF_27219007_Chip-Seq_Bcells_Human0.85079092
154EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.84866702
155ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83791102
156POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83751415
157FUS_26573619_Chip-Seq_HEK293_Human0.81202337
158ER_23166858_ChIP-Seq_MCF-7_Human0.80417274
159PRDM14_20953172_ChIP-Seq_ESCs_Human0.79791713
160VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.79628068
161TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.79277120

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.27908883
2MP0003880_abnormal_central_pattern4.39892005
3MP0003635_abnormal_synaptic_transmissio3.72569482
4MP0003195_calcinosis3.29664012
5MP0008877_abnormal_DNA_methylation3.10948829
6MP0002837_dystrophic_cardiac_calcinosis3.07251704
7MP0009745_abnormal_behavioral_response3.00229274
8MP0002063_abnormal_learning/memory/cond2.99719906
9MP0005423_abnormal_somatic_nervous2.99113379
10MP0004270_analgesia2.96412218
11MP0000569_abnormal_digit_pigmentation2.92565178
12MP0002102_abnormal_ear_morphology2.75412445
13MP0002064_seizures2.74391595
14MP0001968_abnormal_touch/_nociception2.62188206
15MP0002572_abnormal_emotion/affect_behav2.58455490
16MP0001486_abnormal_startle_reflex2.49872997
17MP0009046_muscle_twitch2.42635350
18MP0002272_abnormal_nervous_system2.35449321
19MP0002734_abnormal_mechanical_nocicepti2.32365229
20MP0003646_muscle_fatigue2.29791955
21MP0002876_abnormal_thyroid_physiology2.22218642
22MP0002736_abnormal_nociception_after2.14667997
23MP0002822_catalepsy2.12509903
24MP0000778_abnormal_nervous_system2.09565496
25MP0001986_abnormal_taste_sensitivity2.07373075
26MP0004043_abnormal_pH_regulation2.02798204
27MP0004858_abnormal_nervous_system2.02754643
28MP0000427_abnormal_hair_cycle1.98239296
29MP0005645_abnormal_hypothalamus_physiol1.97927990
30MP0001440_abnormal_grooming_behavior1.93188382
31MP0002184_abnormal_innervation1.92896068
32MP0005646_abnormal_pituitary_gland1.91389099
33MP0002557_abnormal_social/conspecific_i1.88102141
34MP0008872_abnormal_physiological_respon1.86470620
35MP0001984_abnormal_olfaction1.84361735
36MP0002733_abnormal_thermal_nociception1.83955023
37MP0000372_irregular_coat_pigmentation1.83768577
38MP0009780_abnormal_chondrocyte_physiolo1.82466197
39MP0002067_abnormal_sensory_capabilities1.80168653
40MP0001501_abnormal_sleep_pattern1.77534349
41MP0001970_abnormal_pain_threshold1.76021736
42MP0002735_abnormal_chemical_nociception1.72685905
43MP0003122_maternal_imprinting1.62628725
44MP0000955_abnormal_spinal_cord1.60676252
45MP0006276_abnormal_autonomic_nervous1.55700463
46MP0008569_lethality_at_weaning1.55257210
47MP0001188_hyperpigmentation1.54498628
48MP0004142_abnormal_muscle_tone1.52398801
49MP0004885_abnormal_endolymph1.52234089
50MP0003329_amyloid_beta_deposits1.49749463
51MP0003950_abnormal_plasma_membrane1.49703126
52MP0002138_abnormal_hepatobiliary_system1.49357138
53MP0002909_abnormal_adrenal_gland1.47669863
54MP0004811_abnormal_neuron_physiology1.46858549
55MP0004147_increased_porphyrin_level1.44812074
56MP0008875_abnormal_xenobiotic_pharmacok1.44542747
57MP0002882_abnormal_neuron_morphology1.44353487
58MP0001502_abnormal_circadian_rhythm1.40748284
59MP0002163_abnormal_gland_morphology1.39926623
60MP0003252_abnormal_bile_duct1.37642401
61MP0000383_abnormal_hair_follicle1.35889595
62MP0003787_abnormal_imprinting1.34456830
63MP0003011_delayed_dark_adaptation1.33356299
64MP0004924_abnormal_behavior1.32147893
65MP0005386_behavior/neurological_phenoty1.32147893
66MP0002066_abnormal_motor_capabilities/c1.31014405
67MP0004215_abnormal_myocardial_fiber1.30215721
68MP0005174_abnormal_tail_pigmentation1.27856429
69MP0003283_abnormal_digestive_organ1.27404594
70MP0001529_abnormal_vocalization1.25435853
71MP0002928_abnormal_bile_duct1.21761425
72MP0000631_abnormal_neuroendocrine_gland1.20597760
73MP0002938_white_spotting1.17989398
74MP0002152_abnormal_brain_morphology1.17781235
75MP0008775_abnormal_heart_ventricle1.17122046
76MP0005171_absent_coat_pigmentation1.16177078
77MP0008995_early_reproductive_senescence1.15729971
78MP0001905_abnormal_dopamine_level1.15119194
79MP0005084_abnormal_gallbladder_morpholo1.14482480
80MP0005551_abnormal_eye_electrophysiolog1.13819589
81MP0000013_abnormal_adipose_tissue1.13415762
82MP0005379_endocrine/exocrine_gland_phen1.12451323
83MP0004742_abnormal_vestibular_system1.12029908
84MP0005623_abnormal_meninges_morphology1.11940146
85MP0001177_atelectasis1.09446768
86MP0003879_abnormal_hair_cell1.08884441
87MP0003718_maternal_effect1.08028877
88MP0000751_myopathy1.07713778
89MP0000230_abnormal_systemic_arterial1.05886911
90MP0002160_abnormal_reproductive_system1.05338842
91MP0003634_abnormal_glial_cell1.05153895
92MP0005394_taste/olfaction_phenotype1.01841620
93MP0005499_abnormal_olfactory_system1.01841620
94MP0005389_reproductive_system_phenotype1.00240042
95MP0003136_yellow_coat_color1.00037006
96MP0004145_abnormal_muscle_electrophysio0.99791205
97MP0003633_abnormal_nervous_system0.99616024
98MP0002653_abnormal_ependyma_morphology0.97307356
99MP0002752_abnormal_somatic_nervous0.95489677
100MP0001485_abnormal_pinna_reflex0.92928807
101MP0006072_abnormal_retinal_apoptosis0.92411708
102MP0001963_abnormal_hearing_physiology0.91724454
103MP0010329_abnormal_lipoprotein_level0.91428199
104MP0002234_abnormal_pharynx_morphology0.90454404
105MP0002069_abnormal_eating/drinking_beha0.90076468
106MP0005075_abnormal_melanosome_morpholog0.90029779
107MP0002254_reproductive_system_inflammat0.89433916
108MP0005332_abnormal_amino_acid0.88737838
109MP0005195_abnormal_posterior_eye0.88733413
110MP0006292_abnormal_olfactory_placode0.88354865
111MP0003938_abnormal_ear_development0.88014283
112MP0000647_abnormal_sebaceous_gland0.87712439
113MP0005410_abnormal_fertilization0.86687210
114MP0003121_genomic_imprinting0.86453321
115MP0003631_nervous_system_phenotype0.86173515
116MP0000026_abnormal_inner_ear0.85765201
117MP0008058_abnormal_DNA_repair0.85682605
118MP0003137_abnormal_impulse_conducting0.85482753
119MP0000538_abnormal_urinary_bladder0.85019630
120MP0003385_abnormal_body_wall0.84697402
121MP0002638_abnormal_pupillary_reflex0.84093336
122MP0000015_abnormal_ear_pigmentation0.83724446
123MP0010386_abnormal_urinary_bladder0.82405663
124MP0002693_abnormal_pancreas_physiology0.82275951
125MP0005085_abnormal_gallbladder_physiolo0.80627274
126MP0004133_heterotaxia0.80196312
127MP0004085_abnormal_heartbeat0.78909011
128MP0004484_altered_response_of0.78381819
129MP0003698_abnormal_male_reproductive0.78308368
130MP0002095_abnormal_skin_pigmentation0.78266069
131MP0000049_abnormal_middle_ear0.77739277
132MP0000534_abnormal_ureter_morphology0.76598785
133MP0003690_abnormal_glial_cell0.76331676
134MP0010678_abnormal_skin_adnexa0.76329810
135MP0003861_abnormal_nervous_system0.76275694
136MP0005409_darkened_coat_color0.76008260
137MP0001299_abnormal_eye_distance/0.74857485
138MP0002229_neurodegeneration0.74565767
139MP0002090_abnormal_vision0.72783152
140MP0002249_abnormal_larynx_morphology0.70283327
141MP0001943_abnormal_respiration0.68830225
142MP0003942_abnormal_urinary_system0.68605040
143MP0000920_abnormal_myelination0.68000971
144MP0001664_abnormal_digestion0.65908760
145MP0005253_abnormal_eye_physiology0.64578830
146MP0008789_abnormal_olfactory_epithelium0.64454107
147MP0004233_abnormal_muscle_weight0.63806012
148MP0005167_abnormal_blood-brain_barrier0.63771288
149MP0002751_abnormal_autonomic_nervous0.63347829
150MP0003632_abnormal_nervous_system0.63202992
151MP0002089_abnormal_postnatal_growth/wei0.62846330
152MP0009250_abnormal_appendicular_skeleto0.62813913

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.19705977
2Myokymia (HP:0002411)5.46154958
3Pancreatic cysts (HP:0001737)4.91240535
4Focal seizures (HP:0007359)4.64188545
5Pancreatic fibrosis (HP:0100732)4.61049626
6Epileptic encephalopathy (HP:0200134)4.33178787
7Visual hallucinations (HP:0002367)4.25211974
8Molar tooth sign on MRI (HP:0002419)4.20101159
9Abnormality of midbrain morphology (HP:0002418)4.20101159
10True hermaphroditism (HP:0010459)4.06060062
11Febrile seizures (HP:0002373)4.01177225
12Nephronophthisis (HP:0000090)3.83030040
13Atonic seizures (HP:0010819)3.81958467
14Congenital stationary night blindness (HP:0007642)3.77373827
15Progressive cerebellar ataxia (HP:0002073)3.69161320
16Abnormality of the renal cortex (HP:0011035)3.49626678
17Abnormality of the renal medulla (HP:0100957)3.34297348
18Type II lissencephaly (HP:0007260)3.28815741
19Chronic hepatic failure (HP:0100626)3.27461762
20Absence seizures (HP:0002121)3.18479342
21Supranuclear gaze palsy (HP:0000605)3.09341320
22Generalized tonic-clonic seizures (HP:0002069)3.09095669
23Hyperventilation (HP:0002883)3.05797199
24Dialeptic seizures (HP:0011146)3.05323472
25Cystic liver disease (HP:0006706)3.04467089
26Megalencephaly (HP:0001355)3.01356951
27Broad-based gait (HP:0002136)2.96243842
28Action tremor (HP:0002345)2.93762830
29Attenuation of retinal blood vessels (HP:0007843)2.91351755
30Ankle clonus (HP:0011448)2.91113179
31Abolished electroretinogram (ERG) (HP:0000550)2.90760069
32Hemiparesis (HP:0001269)2.81006342
33Renal cortical cysts (HP:0000803)2.78056374
34Tubular atrophy (HP:0000092)2.77944481
35Absent speech (HP:0001344)2.77222300
36Anxiety (HP:0000739)2.74366384
37Obstructive sleep apnea (HP:0002870)2.72536774
38Aplasia/Hypoplasia of the tongue (HP:0010295)2.69718848
39Pendular nystagmus (HP:0012043)2.69632803
40Abnormal drinking behavior (HP:0030082)2.69557931
41Polydipsia (HP:0001959)2.69557931
42Increased corneal curvature (HP:0100692)2.68131926
43Keratoconus (HP:0000563)2.68131926
44Amblyopia (HP:0000646)2.65936790
45Neurofibrillary tangles (HP:0002185)2.63873180
46Abnormal biliary tract physiology (HP:0012439)2.62430401
47Bile duct proliferation (HP:0001408)2.62430401
48Dysdiadochokinesis (HP:0002075)2.60199321
49Limb dystonia (HP:0002451)2.58632251
50Gait imbalance (HP:0002141)2.58496514
51Abnormal eating behavior (HP:0100738)2.58222122
52Hypothermia (HP:0002045)2.54990610
53Depression (HP:0000716)2.52205086
54Aplasia/Hypoplasia of the tibia (HP:0005772)2.51168818
55Abnormality of binocular vision (HP:0011514)2.47037675
56Diplopia (HP:0000651)2.47037675
57Poor eye contact (HP:0000817)2.46136059
58Fair hair (HP:0002286)2.44507383
59Excessive salivation (HP:0003781)2.44378340
60Drooling (HP:0002307)2.44378340
61Sclerocornea (HP:0000647)2.41457140
62Polyphagia (HP:0002591)2.40731379
63Impaired vibration sensation in the lower limbs (HP:0002166)2.40161768
64Congenital hepatic fibrosis (HP:0002612)2.38755993
65Abnormality of macular pigmentation (HP:0008002)2.34788497
66Lissencephaly (HP:0001339)2.33868471
67Abnormal rod and cone electroretinograms (HP:0008323)2.31897460
68Sleep apnea (HP:0010535)2.29096233
69Narrow nasal bridge (HP:0000446)2.27578596
70Cerebral inclusion bodies (HP:0100314)2.26063427
71Anencephaly (HP:0002323)2.25602335
72Dysmetria (HP:0001310)2.25564774
73Torticollis (HP:0000473)2.25529153
74Retinal dysplasia (HP:0007973)2.23468585
75Ketoacidosis (HP:0001993)2.23360570
76Cerebellar dysplasia (HP:0007033)2.23245026
77Aplasia involving bones of the upper limbs (HP:0009823)2.23024471
78Aplasia of the phalanges of the hand (HP:0009802)2.23024471
79Aplasia involving bones of the extremities (HP:0009825)2.23024471
80Decreased central vision (HP:0007663)2.22408815
81Furrowed tongue (HP:0000221)2.22080354
82Fetal akinesia sequence (HP:0001989)2.21852629
83Pachygyria (HP:0001302)2.20364653
84Polyuria (HP:0000103)2.19983343
85Mutism (HP:0002300)2.19198052
86Chorioretinal atrophy (HP:0000533)2.16285554
87Abnormal social behavior (HP:0012433)2.12810120
88Impaired social interactions (HP:0000735)2.12810120
89Genetic anticipation (HP:0003743)2.12783256
90Generalized hypotonia (HP:0001290)2.11460216
91Postaxial foot polydactyly (HP:0001830)2.11267926
92Congenital primary aphakia (HP:0007707)2.10679675
93Protruding tongue (HP:0010808)2.09571687
94Truncal ataxia (HP:0002078)2.08559459
95Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07267955
96Abnormality of alanine metabolism (HP:0010916)2.07267955
97Hyperalaninemia (HP:0003348)2.07267955
98Gaze-evoked nystagmus (HP:0000640)2.07057718
99Medial flaring of the eyebrow (HP:0010747)2.06763471
100Focal dystonia (HP:0004373)2.05638476
101Decreased electroretinogram (ERG) amplitude (HP:0000654)2.05177640
102Synostosis involving the elbow (HP:0003938)2.03790289
103Humeroradial synostosis (HP:0003041)2.03790289
104Occipital encephalocele (HP:0002085)2.03610294
105Epileptiform EEG discharges (HP:0011182)2.03466218
106Specific learning disability (HP:0001328)2.02753395
107Status epilepticus (HP:0002133)2.02114348
108Methylmalonic acidemia (HP:0002912)1.98735967
109Ketosis (HP:0001946)1.98689202
110Large for gestational age (HP:0001520)1.98349932
111Stereotypic behavior (HP:0000733)1.98294097
112Split foot (HP:0001839)1.98253206
113Agitation (HP:0000713)1.98224189
114Progressive inability to walk (HP:0002505)1.97318683
115Bony spicule pigmentary retinopathy (HP:0007737)1.97119956
116Male pseudohermaphroditism (HP:0000037)1.96551854
117Decreased circulating renin level (HP:0003351)1.96169492
118Increased CSF lactate (HP:0002490)1.95786291
119Aplasia/Hypoplasia of the spleen (HP:0010451)1.95447061
120EEG with generalized epileptiform discharges (HP:0011198)1.93541008
121Urinary bladder sphincter dysfunction (HP:0002839)1.92770072
122Lower limb muscle weakness (HP:0007340)1.91457009
123Hypoventilation (HP:0002791)1.89105708
124Hemiplegia (HP:0002301)1.87426572
125Scanning speech (HP:0002168)1.86744845
126Mitochondrial inheritance (HP:0001427)1.86719798
127Disproportionate short-trunk short stature (HP:0003521)1.85998995
128Nephrogenic diabetes insipidus (HP:0009806)1.85363256
129Craniofacial dystonia (HP:0012179)1.85347282
130Acute necrotizing encephalopathy (HP:0006965)1.84968119
131Generalized hypopigmentation of hair (HP:0011358)1.84748556
132Postural instability (HP:0002172)1.84277461
133Poor coordination (HP:0002370)1.84145706
134Short tibia (HP:0005736)1.83985185
135Spastic gait (HP:0002064)1.83665816
136Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83272428
137Genital tract atresia (HP:0001827)1.82528822
138Hypsarrhythmia (HP:0002521)1.82468503
139Vaginal atresia (HP:0000148)1.81838104
140Dynein arm defect of respiratory motile cilia (HP:0012255)1.81110932
141Absent/shortened dynein arms (HP:0200106)1.81110932
142Progressive macrocephaly (HP:0004481)1.80963925
143Postaxial hand polydactyly (HP:0001162)1.80625917
144Thickened helices (HP:0000391)1.79280501
145Anosmia (HP:0000458)1.78158927
146Blue irides (HP:0000635)1.78115325
147Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77897744
148Severe muscular hypotonia (HP:0006829)1.77142479
149Clumsiness (HP:0002312)1.76145319
150Urinary urgency (HP:0000012)1.75993562
151Small hand (HP:0200055)1.75878972
152Methylmalonic aciduria (HP:0012120)1.75562966
153Aplasia/Hypoplasia of the brainstem (HP:0007362)1.75409516
154Hypoplasia of the brainstem (HP:0002365)1.75409516
155Asplenia (HP:0001746)1.74439617
156Lower limb amyotrophy (HP:0007210)1.73436215
157Inability to walk (HP:0002540)1.72706623
158Preaxial hand polydactyly (HP:0001177)1.72666506
159Congenital sensorineural hearing impairment (HP:0008527)1.72585026
160Optic nerve hypoplasia (HP:0000609)1.72349480
161Impaired smooth pursuit (HP:0007772)1.71629101
162Hypomagnesemia (HP:0002917)1.71435408
163Concave nail (HP:0001598)1.70714375
164Widely spaced teeth (HP:0000687)1.70603544
165Bronchomalacia (HP:0002780)1.70303209
166Dandy-Walker malformation (HP:0001305)1.70234130
167Intention tremor (HP:0002080)1.70186007
168Retinitis pigmentosa (HP:0000510)1.70016122
169Tubulointerstitial nephritis (HP:0001970)1.69661010
170Pheochromocytoma (HP:0002666)1.69303002
171Cutaneous finger syndactyly (HP:0010554)1.69005258
172Esotropia (HP:0000565)1.69003581
173Abnormality of the corticospinal tract (HP:0002492)1.63988145
174Abnormality of salivation (HP:0100755)1.62252985
175Aqueductal stenosis (HP:0002410)1.61982685
176Insomnia (HP:0100785)1.61245420
177Spinal canal stenosis (HP:0003416)1.60903641
178Morphological abnormality of the middle ear (HP:0008609)1.60308008
179Septo-optic dysplasia (HP:0100842)1.59790435
180Incomplete penetrance (HP:0003829)1.58657391

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.54408337
2CASK5.88035341
3EPHA44.23738591
4NTRK34.15483077
5MARK13.49601300
6BMPR1B3.18285618
7MAP4K22.84347557
8ADRBK22.80994430
9NUAK12.75297707
10GRK12.45392539
11MAP3K92.44329651
12NTRK22.33439248
13MAP3K42.28358263
14ACVR1B2.27779435
15MINK12.26211936
16ZAK2.14372560
17MAP2K72.07809113
18WNK42.04036088
19TAOK31.89955646
20PHKG11.87657050
21PHKG21.87657050
22DAPK21.84322877
23PAK61.80674772
24TLK11.77606838
25INSRR1.71322115
26PRPF4B1.64489520
27MAPK131.64249008
28TNIK1.63525053
29STK38L1.62801131
30PLK21.60431207
31PRKD31.57188667
32STK391.55406814
33TRIM281.53691843
34NTRK11.53464734
35MKNK21.51528278
36CDK51.45560431
37GRK51.44677324
38UHMK11.40792481
39CDK191.39575696
40TYRO31.37186122
41KSR11.32885050
42MAP3K121.27148090
43MST41.26076570
44MAP2K41.26044604
45TGFBR11.19220127
46CAMKK11.19099958
47SIK21.16529231
48PRKCG1.16318909
49LATS21.12726511
50TXK1.08201477
51TIE11.05170391
52CAMK2A1.04079149
53KSR21.02338142
54FGFR21.00002528
55DAPK10.99826094
56SGK2230.96252305
57SGK4940.96252305
58PNCK0.96189377
59FES0.92279515
60LMTK20.91566388
61CAMK2B0.90914101
62CAMK10.90065592
63CDK180.88744738
64CDK140.87989021
65CDK150.86486527
66RIPK40.84615065
67BRSK20.83211433
68MARK20.83173474
69CSNK1G20.82934574
70ARAF0.81668927
71PAK30.80473196
72EIF2AK30.80109143
73MKNK10.79823794
74ICK0.78747262
75CDK11A0.77765278
76DDR20.77461624
77CSNK1G10.76896231
78DYRK1A0.75783224
79PRKCE0.75765713
80OBSCN0.75332723
81STK380.74677895
82CCNB10.74377529
83BCKDK0.73584445
84TEC0.71841407
85NLK0.71122881
86PKN10.69767935
87STK110.69603343
88EPHB20.67966907
89ERBB30.67404199
90PRKCH0.67308598
91PIK3CA0.66883645
92OXSR10.66587654
93STK30.66231075
94CAMKK20.66118082
95SGK20.65852947
96PINK10.64517522
97PRKD20.64069336
98VRK10.64024938
99DYRK20.63091154
100MAPKAPK50.62286803
101PTK2B0.62184273
102PDGFRA0.61606036
103TAOK10.61336069
104FER0.60350253
105TAF10.58831712
106IKBKB0.57460877
107MAP3K20.57326161
108MAPKAPK30.57299645
109CAMK2D0.56912382
110CDC42BPA0.56356951
111MAP3K70.56004734
112PLK30.55856603
113AKT30.55758645
114PRKCZ0.55547265
115SIK30.55250033
116MAP2K60.55224602
117CAMK2G0.54991496
118SGK10.54853527
119BRAF0.54136722
120TNK20.53000883
121RET0.52732653
122MAPK150.51165894
123FLT30.50627757
124ROCK20.50226587
125ADRBK10.50129847
126CSNK1G30.48557840
127FGR0.47377528
128PRKAA10.47354501
129PRKAA20.46797320
130MUSK0.46736932
131BMPR20.46058517
132CAMK40.45966052
133CSNK1A1L0.45958532
134CDK80.45771454
135WNK30.44131505
136CHUK0.44033157
137ALK0.43124941
138SGK30.42850579
139PRKACA0.42793014
140PRKCQ0.41911245
141PIK3CG0.41637195
142ROCK10.41630600
143LIMK10.40605497
144CSNK1D0.40127384
145MAPK120.39383196
146CSNK1A10.39263417
147DAPK30.38979351
148EPHA30.37262436
149STK240.37201055
150STK160.37123533
151BCR0.37069229
152RPS6KA30.36977846
153PRKG10.35889563
154NEK20.35418691
155PRKCI0.33093645
156ABL10.31946673
157KIT0.31136866
158PRKCA0.30572447
159RPS6KA50.29369081
160PRKACB0.29313358

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.85176972
2Synaptic vesicle cycle_Homo sapiens_hsa047213.11725557
3GABAergic synapse_Homo sapiens_hsa047272.79167329
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.64952025
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.61249012
6Linoleic acid metabolism_Homo sapiens_hsa005912.58977911
7Morphine addiction_Homo sapiens_hsa050322.56780065
8Circadian entrainment_Homo sapiens_hsa047132.56699216
9Glutamatergic synapse_Homo sapiens_hsa047242.56561636
10Olfactory transduction_Homo sapiens_hsa047402.55533260
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.46034620
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.46021788
13Amphetamine addiction_Homo sapiens_hsa050312.42078995
14Butanoate metabolism_Homo sapiens_hsa006502.40896558
15Nitrogen metabolism_Homo sapiens_hsa009102.40882773
16Long-term potentiation_Homo sapiens_hsa047202.20064362
17Dopaminergic synapse_Homo sapiens_hsa047282.11734104
18Insulin secretion_Homo sapiens_hsa049112.03369104
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.01844975
20Selenocompound metabolism_Homo sapiens_hsa004502.01082608
21Salivary secretion_Homo sapiens_hsa049701.98795177
22Protein export_Homo sapiens_hsa030601.97898347
23Cocaine addiction_Homo sapiens_hsa050301.96838515
24Ether lipid metabolism_Homo sapiens_hsa005651.96053512
25Tryptophan metabolism_Homo sapiens_hsa003801.95378738
26Taste transduction_Homo sapiens_hsa047421.93493459
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.88405327
28Cholinergic synapse_Homo sapiens_hsa047251.85168654
29Propanoate metabolism_Homo sapiens_hsa006401.83891218
30Serotonergic synapse_Homo sapiens_hsa047261.77143413
31Caffeine metabolism_Homo sapiens_hsa002321.75297674
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73310135
33Long-term depression_Homo sapiens_hsa047301.70255157
34Gastric acid secretion_Homo sapiens_hsa049711.69915188
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.69715059
36Basal transcription factors_Homo sapiens_hsa030221.68700196
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.61743211
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61641904
39Renin secretion_Homo sapiens_hsa049241.59365186
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57742889
41Axon guidance_Homo sapiens_hsa043601.55458788
42Oxytocin signaling pathway_Homo sapiens_hsa049211.53557325
43Calcium signaling pathway_Homo sapiens_hsa040201.51680500
44Gap junction_Homo sapiens_hsa045401.47709579
45Collecting duct acid secretion_Homo sapiens_hsa049661.46826026
46Fanconi anemia pathway_Homo sapiens_hsa034601.36177946
47Homologous recombination_Homo sapiens_hsa034401.35554798
48Regulation of autophagy_Homo sapiens_hsa041401.33279187
49GnRH signaling pathway_Homo sapiens_hsa049121.32434378
50ABC transporters_Homo sapiens_hsa020101.30713896
51RNA polymerase_Homo sapiens_hsa030201.25911692
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25543005
53Cardiac muscle contraction_Homo sapiens_hsa042601.23498096
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23463803
55Vibrio cholerae infection_Homo sapiens_hsa051101.22456131
56cAMP signaling pathway_Homo sapiens_hsa040241.22369689
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.21846489
58Steroid hormone biosynthesis_Homo sapiens_hsa001401.21084183
59Peroxisome_Homo sapiens_hsa041461.20794723
60Melanogenesis_Homo sapiens_hsa049161.20184717
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11631653
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11467691
63Arachidonic acid metabolism_Homo sapiens_hsa005901.09754449
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08735338
65RNA degradation_Homo sapiens_hsa030181.08669989
66Glioma_Homo sapiens_hsa052141.07121065
67Estrogen signaling pathway_Homo sapiens_hsa049151.05793973
68Sulfur metabolism_Homo sapiens_hsa009201.04846604
69Chemical carcinogenesis_Homo sapiens_hsa052041.02884822
70Phototransduction_Homo sapiens_hsa047441.01426717
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99250691
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99129193
73ErbB signaling pathway_Homo sapiens_hsa040120.99083000
74Retinol metabolism_Homo sapiens_hsa008300.97571878
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96596270
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96148846
77Dilated cardiomyopathy_Homo sapiens_hsa054140.95800000
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93757558
79beta-Alanine metabolism_Homo sapiens_hsa004100.93181180
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91610642
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.91125940
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89978742
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.88537824
84One carbon pool by folate_Homo sapiens_hsa006700.85934876
85Type II diabetes mellitus_Homo sapiens_hsa049300.85861837
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84508861
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84454441
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81257070
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.81166713
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80891702
91Glycerolipid metabolism_Homo sapiens_hsa005610.79619783
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79452499
93Hedgehog signaling pathway_Homo sapiens_hsa043400.79086883
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79059223
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78116275
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74388988
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73738140
98MAPK signaling pathway_Homo sapiens_hsa040100.71646167
99Pancreatic secretion_Homo sapiens_hsa049720.70988319
100Wnt signaling pathway_Homo sapiens_hsa043100.70889852
101Thyroid hormone synthesis_Homo sapiens_hsa049180.70739144
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70405082
103Choline metabolism in cancer_Homo sapiens_hsa052310.70102122
104Sphingolipid metabolism_Homo sapiens_hsa006000.70026839
105Alzheimers disease_Homo sapiens_hsa050100.69500756
106Oocyte meiosis_Homo sapiens_hsa041140.68995249
107Ras signaling pathway_Homo sapiens_hsa040140.68971229
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67975273
109Fatty acid degradation_Homo sapiens_hsa000710.66500306
110Mineral absorption_Homo sapiens_hsa049780.64824533
111Alcoholism_Homo sapiens_hsa050340.63976611
112Purine metabolism_Homo sapiens_hsa002300.62662088
113Fat digestion and absorption_Homo sapiens_hsa049750.62593628
114Rap1 signaling pathway_Homo sapiens_hsa040150.62054525
115Dorso-ventral axis formation_Homo sapiens_hsa043200.60752174
116Oxidative phosphorylation_Homo sapiens_hsa001900.60611264
117Metabolic pathways_Homo sapiens_hsa011000.59857292
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59820430
119Fatty acid elongation_Homo sapiens_hsa000620.57539209
120Steroid biosynthesis_Homo sapiens_hsa001000.57249221
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.56564231
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.55849071
123Histidine metabolism_Homo sapiens_hsa003400.55329267
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54749700
125Non-homologous end-joining_Homo sapiens_hsa034500.53170876
126Renal cell carcinoma_Homo sapiens_hsa052110.51248235
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50441637
128Parkinsons disease_Homo sapiens_hsa050120.50437341
129Ovarian steroidogenesis_Homo sapiens_hsa049130.50219093
130Basal cell carcinoma_Homo sapiens_hsa052170.48825158
131Fatty acid metabolism_Homo sapiens_hsa012120.46999431
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46348579
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.45951017
134Glucagon signaling pathway_Homo sapiens_hsa049220.45886562
135Circadian rhythm_Homo sapiens_hsa047100.45395960
136SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43993989
137Lysine degradation_Homo sapiens_hsa003100.43447295
138Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43223219
139Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42963448
140Endocytosis_Homo sapiens_hsa041440.42689319
141Hippo signaling pathway_Homo sapiens_hsa043900.42668167
142Endometrial cancer_Homo sapiens_hsa052130.42480086
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42282727
144Prion diseases_Homo sapiens_hsa050200.42270338
145Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41135744
146VEGF signaling pathway_Homo sapiens_hsa043700.41037770
147Type I diabetes mellitus_Homo sapiens_hsa049400.40407782
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39700135
149Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39133360
150Melanoma_Homo sapiens_hsa052180.38241263
151Tight junction_Homo sapiens_hsa045300.38017873
152Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37952891
153Glycerophospholipid metabolism_Homo sapiens_hsa005640.34015955
154Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32206138
155Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31765950
156Asthma_Homo sapiens_hsa053100.31346619
157Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31128315
158Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31061532
159Huntingtons disease_Homo sapiens_hsa050160.30980067
160Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27800833
161Insulin signaling pathway_Homo sapiens_hsa049100.26499213

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