PCDHGB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1metanephric mesenchyme development (GO:0072075)5.72808161
2kidney mesenchyme development (GO:0072074)5.30583827
3COPI coating of Golgi vesicle (GO:0048205)4.81646389
4Golgi transport vesicle coating (GO:0048200)4.81646389
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.49693124
6synaptic vesicle maturation (GO:0016188)4.48501074
7generation of neurons (GO:0048699)4.43729194
8locomotory exploration behavior (GO:0035641)4.21805983
9synaptic vesicle exocytosis (GO:0016079)4.16774285
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.06580419
11synaptic vesicle docking involved in exocytosis (GO:0016081)3.99813396
12muscle cell migration (GO:0014812)3.95948146
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.92180584
14protein retention in ER lumen (GO:0006621)3.88403264
15vocalization behavior (GO:0071625)3.87148825
16positive regulation of synapse maturation (GO:0090129)3.80037263
17organ induction (GO:0001759)3.74624640
18maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.71602829
19cellular potassium ion homeostasis (GO:0030007)3.70811697
20membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.68660343
21negative regulation of catenin import into nucleus (GO:0035414)3.68182793
22regulation of synaptic vesicle exocytosis (GO:2000300)3.67875838
23regulation of synapse structural plasticity (GO:0051823)3.65206600
24mesenchymal cell differentiation involved in kidney development (GO:0072161)3.64785719
25mesenchymal cell differentiation involved in renal system development (GO:2001012)3.64785719
26planar cell polarity pathway involved in neural tube closure (GO:0090179)3.64528843
27regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.63632400
28layer formation in cerebral cortex (GO:0021819)3.61144999
29regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.60791619
30neuron cell-cell adhesion (GO:0007158)3.59397684
31axonal fasciculation (GO:0007413)3.58534918
32embryonic skeletal joint morphogenesis (GO:0060272)3.57443052
33protein maturation by protein folding (GO:0022417)3.57212605
34dendrite morphogenesis (GO:0048813)3.56719472
35glutamate secretion (GO:0014047)3.56713862
36innervation (GO:0060384)3.52372776
37cell communication by electrical coupling (GO:0010644)3.49745044
38regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.48851111
39detection of light stimulus involved in visual perception (GO:0050908)3.43524191
40detection of light stimulus involved in sensory perception (GO:0050962)3.43524191
41cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.40591554
42G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.38921730
43negative regulation of kidney development (GO:0090185)3.34745664
44neurotransmitter-gated ion channel clustering (GO:0072578)3.34029414
45protein localization to synapse (GO:0035418)3.33931647
46central nervous system projection neuron axonogenesis (GO:0021952)3.33079934
47regulation of glutamate receptor signaling pathway (GO:1900449)3.32201817
48retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.27383216
49nephron tubule formation (GO:0072079)3.26078209
50negative regulation of cytosolic calcium ion concentration (GO:0051481)3.24527325
51dendritic spine morphogenesis (GO:0060997)3.24240945
52response to pheromone (GO:0019236)3.20230456
53atrial cardiac muscle cell action potential (GO:0086014)3.19903874
54negative regulation of chondrocyte differentiation (GO:0032331)3.17924101
55cranial nerve morphogenesis (GO:0021602)3.17607846
56substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.15852394
57substrate-independent telencephalic tangential migration (GO:0021826)3.15852394
58myoblast migration (GO:0051451)3.15216292
59sodium ion export (GO:0071436)3.13558188
60exploration behavior (GO:0035640)3.13209989
61mesonephros development (GO:0001823)3.09287163
62neuron recognition (GO:0008038)3.08068248
63regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.06943171
64ionotropic glutamate receptor signaling pathway (GO:0035235)3.05007202
65potassium ion homeostasis (GO:0055075)3.04164388
66regulation of neuronal synaptic plasticity (GO:0048168)3.03494314
67regulation of synaptic vesicle transport (GO:1902803)3.03185498
68striatum development (GO:0021756)3.02934521
69axon extension (GO:0048675)3.01035228
70synaptic transmission, glutamatergic (GO:0035249)3.00942489
71G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.00922332
72regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.99168052
73cell proliferation involved in metanephros development (GO:0072203)2.97226902
74glutamate receptor signaling pathway (GO:0007215)2.97124848
75regulation of long-term neuronal synaptic plasticity (GO:0048169)2.93903953
76positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.93430304
77synaptic vesicle endocytosis (GO:0048488)2.92624043
78neurotransmitter secretion (GO:0007269)2.92323406
79regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.92246941
80neuron projection extension involved in neuron projection guidance (GO:1902284)2.91801228
81axon extension involved in axon guidance (GO:0048846)2.91801228
82protein targeting to plasma membrane (GO:0072661)2.89779186
83membrane depolarization during action potential (GO:0086010)2.89680671
84cytoskeletal anchoring at plasma membrane (GO:0007016)2.87348662
85regulation of synapse maturation (GO:0090128)2.84600524
86cochlea morphogenesis (GO:0090103)2.82677592
87cell proliferation involved in kidney development (GO:0072111)2.80294627
88synapse assembly (GO:0007416)2.78765685
89prepulse inhibition (GO:0060134)2.78286424
90positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.77964161
91pattern specification involved in kidney development (GO:0061004)2.76420058
92skin morphogenesis (GO:0043589)2.76252626
93developmental induction (GO:0031128)2.75052014
94* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.74729314
95cerebellar Purkinje cell differentiation (GO:0021702)2.74629100
96response to auditory stimulus (GO:0010996)2.74541546
97actin filament depolymerization (GO:0030042)2.74009609
98regulation of excitatory postsynaptic membrane potential (GO:0060079)2.72826534
99cell migration in hindbrain (GO:0021535)2.72217662
100cerebellar granule cell differentiation (GO:0021707)2.71990050
101urinary tract smooth muscle contraction (GO:0014848)2.71580247
102establishment of nucleus localization (GO:0040023)2.71026051
103neuron-neuron synaptic transmission (GO:0007270)2.70690940
104long-term memory (GO:0007616)2.70105461
105endothelial cell chemotaxis (GO:0035767)2.69742854
106regulation of synaptic transmission, glutamatergic (GO:0051966)2.69252992
107semaphorin-plexin signaling pathway (GO:0071526)2.68566075
108regulation of postsynaptic membrane potential (GO:0060078)2.68513004
109neuron projection extension (GO:1990138)2.67239295
110cell communication involved in cardiac conduction (GO:0086065)2.67140366
111membrane hyperpolarization (GO:0060081)2.66246978
112regulation of axon extension involved in axon guidance (GO:0048841)2.65944650
113peripheral nervous system neuron development (GO:0048935)2.65322689
114vesicle coating (GO:0006901)2.63468475
115positive regulation of dendritic spine morphogenesis (GO:0061003)2.61916615
116positive regulation of membrane potential (GO:0045838)2.61739514
117regulation of extracellular matrix disassembly (GO:0010715)2.59278916
118proximal/distal pattern formation (GO:0009954)2.58874767
119barbed-end actin filament capping (GO:0051016)2.58123901
120protein localization to endosome (GO:0036010)2.57154439
121chemosensory behavior (GO:0007635)2.57023386
122paraxial mesoderm development (GO:0048339)2.56728351
123cell-cell signaling involved in cell fate commitment (GO:0045168)2.56460042
124postsynaptic membrane organization (GO:0001941)2.55707336
125neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.55697208
126regulation of neurotransmitter secretion (GO:0046928)2.55446785
127regulation of establishment of planar polarity (GO:0090175)2.54450506
128cerebellar Purkinje cell layer development (GO:0021680)2.54377703
129ganglion development (GO:0061548)2.53605205
130type B pancreatic cell proliferation (GO:0044342)2.53391579
131limb development (GO:0060173)2.52957778
132appendage development (GO:0048736)2.52957778
133fibroblast migration (GO:0010761)2.52721037
134Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.51825179
135growth hormone secretion (GO:0030252)2.51748325
136extracellular fibril organization (GO:0043206)2.51149275
137cellular sodium ion homeostasis (GO:0006883)2.50791075
138regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.50612474
139potassium ion import (GO:0010107)2.50463322
140positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.49555245
141synapse organization (GO:0050808)2.49462177
142activation of protein kinase A activity (GO:0034199)2.49405157
143auditory behavior (GO:0031223)2.48958940
144regulation of secondary heart field cardioblast proliferation (GO:0003266)2.48509920
145regulation of cardioblast proliferation (GO:0003264)2.48509920
146mitotic nuclear envelope reassembly (GO:0007084)2.48043218
147nuclear envelope reassembly (GO:0031468)2.48043218
148positive regulation of vesicle fusion (GO:0031340)2.47839827
149regulation of mammary gland epithelial cell proliferation (GO:0033599)2.47476193
150regulation of cardioblast differentiation (GO:0051890)2.46033728
151gamma-aminobutyric acid transport (GO:0015812)2.45660506
152inner ear receptor cell differentiation (GO:0060113)2.45519236
153mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.45375851
154central nervous system neuron axonogenesis (GO:0021955)2.45322312
155regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.43698160
156mating behavior (GO:0007617)2.43114611
157regulation of synaptic plasticity (GO:0048167)2.43061669
158regulation of axon guidance (GO:1902667)2.42989691
159negative regulation of embryonic development (GO:0045992)2.42207333
160dendritic spine organization (GO:0097061)2.42101289
161long-term synaptic potentiation (GO:0060291)2.41680345
162regulation of dendritic spine morphogenesis (GO:0061001)2.40419028
163behavioral fear response (GO:0001662)2.40416518
164behavioral defense response (GO:0002209)2.40416518
165negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.40338607
166substrate-dependent cell migration (GO:0006929)2.40292970
167endocardial cushion development (GO:0003197)2.39195132
168regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.38906507
169COPII vesicle coating (GO:0048208)2.37976760
170regulation of neurotransmitter transport (GO:0051588)2.37731803
171membrane depolarization (GO:0051899)2.37337774
172maternal placenta development (GO:0001893)2.37215850
173regulation of membrane repolarization (GO:0060306)2.36994605
174retina vasculature morphogenesis in camera-type eye (GO:0061299)2.35050252
175mesenchyme morphogenesis (GO:0072132)2.34932105
176smooth muscle tissue development (GO:0048745)2.34246339
177hemidesmosome assembly (GO:0031581)2.34230241
178adherens junction assembly (GO:0034333)2.33548008
179vascular endothelial growth factor signaling pathway (GO:0038084)2.32784702
180positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.31505260
181regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.31265769
182regulation of organ formation (GO:0003156)2.26208800
183negative regulation of cell size (GO:0045792)2.25569013
184desmosome organization (GO:0002934)2.25036884
185developmental cell growth (GO:0048588)2.24629705
186macroautophagy (GO:0016236)2.24609632
187developmental growth involved in morphogenesis (GO:0060560)2.24124365
188regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.20308039
189cell-substrate junction assembly (GO:0007044)2.19296744
190regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.19209182
191membrane assembly (GO:0071709)2.18622619
192cell adhesion mediated by integrin (GO:0033627)2.18532681
193SMAD protein complex assembly (GO:0007183)2.17580438
194negative regulation of cartilage development (GO:0061037)2.17258497

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.53655937
2GBX2_23144817_ChIP-Seq_PC3_Human3.47397452
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.26286114
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69933547
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.62440097
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.58440649
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.50048289
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42064626
9ZNF263_19887448_ChIP-Seq_K562_Human2.41680308
10HIF1A_21447827_ChIP-Seq_MCF-7_Human2.40636694
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.40208215
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.40208215
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37866018
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.37818153
15DROSHA_22980978_ChIP-Seq_HELA_Human2.33428062
16ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.30469678
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.27389544
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.27209182
19CLOCK_20551151_ChIP-Seq_293T_Human2.24517142
20ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.23522540
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.22148093
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.17752076
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.16988369
24* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.16979620
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.15637315
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.12145888
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.10710706
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.10210394
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.09204203
30* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.07181513
31ESR1_20079471_ChIP-ChIP_T-47D_Human2.06889515
32ESR1_21235772_ChIP-Seq_MCF-7_Human2.02893758
33RNF2_27304074_Chip-Seq_ESCs_Mouse2.00449918
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.96245797
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.89492631
36REST_21632747_ChIP-Seq_MESCs_Mouse1.85319729
37* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83875440
38AR_21572438_ChIP-Seq_LNCaP_Human1.79839200
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79587951
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.78073735
41RACK7_27058665_Chip-Seq_MCF-7_Human1.75651028
42RARB_27405468_Chip-Seq_BRAIN_Mouse1.70528916
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70260425
44TP53_20018659_ChIP-ChIP_R1E_Mouse1.66545197
45RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.64028904
46SMAD4_21799915_ChIP-Seq_A2780_Human1.63645478
47PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.60011762
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59823172
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59608615
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.56823252
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.52821026
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52006127
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51465428
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.51201125
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.49911289
56ZFP281_27345836_Chip-Seq_ESCs_Mouse1.49107529
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.48496571
58NFIB_24661679_ChIP-Seq_LUNG_Mouse1.48344665
59P300_27058665_Chip-Seq_ZR-75-30cells_Human1.46524076
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.45805197
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.45468974
62CDX2_20551321_ChIP-Seq_CACO-2_Human1.44787369
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.44745481
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43872702
65SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.43810042
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43497455
67SOX2_21211035_ChIP-Seq_LN229_Gbm1.42865974
68WT1_25993318_ChIP-Seq_PODOCYTE_Human1.42577896
69P300_19829295_ChIP-Seq_ESCs_Human1.42147813
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41544977
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41232277
72ZNF274_21170338_ChIP-Seq_K562_Hela1.40493705
73SOX9_24532713_ChIP-Seq_HFSC_Mouse1.39836184
74REST_18959480_ChIP-ChIP_MESCs_Mouse1.39236480
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38705547
76AHR_22903824_ChIP-Seq_MCF-7_Human1.38204480
77EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37955126
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.37270124
79IGF1R_20145208_ChIP-Seq_DFB_Human1.35837030
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35408918
81MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.35103232
82IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34825369
83AR_19668381_ChIP-Seq_PC3_Human1.34697062
84UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33605749
85* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.32927345
86* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.32927345
87CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32659477
88TAF15_26573619_Chip-Seq_HEK293_Human1.32264187
89AR_25329375_ChIP-Seq_VCAP_Human1.31701276
90STAT3_23295773_ChIP-Seq_U87_Human1.30904048
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30461456
92TRIM28_21343339_ChIP-Seq_HEK293_Human1.29852571
93YAP1_20516196_ChIP-Seq_MESCs_Mouse1.29762150
94TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.29603306
95* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29524241
96CBX2_27304074_Chip-Seq_ESCs_Mouse1.28536947
97EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.28467541
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.27888285
99RING1B_27294783_Chip-Seq_ESCs_Mouse1.27761105
100* TP53_23651856_ChIP-Seq_MEFs_Mouse1.27570387
101TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27338288
102KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.26363898
103KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.26363898
104KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.26363898
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26071785
106GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24334297
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22863590
108* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.22468978
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22346566
110EP300_21415370_ChIP-Seq_HL-1_Mouse1.22245739
111SMAD4_21741376_ChIP-Seq_HESCs_Human1.20603199
112TET1_21490601_ChIP-Seq_MESCs_Mouse1.20497961
113TP53_22127205_ChIP-Seq_IMR90_Human1.19174193
114POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19113089
115ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18814151
116RUNX1_27514584_Chip-Seq_MCF-7_Human1.18563767
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17762647
118BCAT_22108803_ChIP-Seq_LS180_Human1.17642017
119DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16072247
120TP53_16413492_ChIP-PET_HCT116_Human1.15263618
121P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15230920
122* ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14553567
123VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14421543
124RING1B_27294783_Chip-Seq_NPCs_Mouse1.14264076
125SMAD3_21741376_ChIP-Seq_HESCs_Human1.14085283
126TBX20_22080862_ChIP-Seq_HEART_Mouse1.13775673
127TBX20_22328084_ChIP-Seq_HEART_Mouse1.13775673
128TCF4_23295773_ChIP-Seq_U87_Human1.12568154
129CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12330892
130TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12079563
131EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11672919
132UBF1/2_26484160_Chip-Seq_HMECs_Human1.11670561
133TP53_18474530_ChIP-ChIP_U2OS_Human1.11197812
134CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10334718
135FUS_26573619_Chip-Seq_HEK293_Human1.09898510
136CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09385948
137ISL1_27105846_Chip-Seq_CPCs_Mouse1.06658477
138BRD4_25478319_ChIP-Seq_HGPS_Human1.05986717
139TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04560135
140CJUN_26792858_Chip-Seq_BT549_Human1.04488604
141TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02830212
142TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02768587
143ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02722248
144TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02560941
145KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01915897
146RXR_22108803_ChIP-Seq_LS180_Human1.01898697
147PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01810213
148NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01413321
149* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01301680
150TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01199139
151POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01199139
152NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00989230
153MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00731490
154CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00727716
155SALL1_21062744_ChIP-ChIP_HESCs_Human1.00668823
156TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00644104
157OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00307755
158KDM2B_26808549_Chip-Seq_K562_Human0.99170492

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.85636130
2MP0004270_analgesia3.41232800
3MP0008438_abnormal_cutaneous_collagen3.30084625
4MP0003635_abnormal_synaptic_transmissio2.98545641
5MP0005257_abnormal_intraocular_pressure2.70541478
6MP0003705_abnormal_hypodermis_morpholog2.68672140
7MP0002063_abnormal_learning/memory/cond2.42493917
8MP0003880_abnormal_central_pattern2.35756109
9MP0002877_abnormal_melanocyte_morpholog2.34818000
10MP0003566_abnormal_cell_adhesion2.27909290
11MP0009780_abnormal_chondrocyte_physiolo2.26313835
12MP0005551_abnormal_eye_electrophysiolog2.23487511
13MP0002734_abnormal_mechanical_nocicepti2.16689335
14MP0001486_abnormal_startle_reflex2.15178428
15MP0004233_abnormal_muscle_weight2.11246650
16MP0000733_abnormal_muscle_development2.09071160
17MP0009745_abnormal_behavioral_response2.03662237
18MP0000778_abnormal_nervous_system2.03345201
19MP0003123_paternal_imprinting2.00698242
20MP0001984_abnormal_olfaction1.99316707
21MP0002064_seizures1.98070649
22MP0003942_abnormal_urinary_system1.96736932
23MP0002572_abnormal_emotion/affect_behav1.93798350
24MP0001299_abnormal_eye_distance/1.93540744
25MP0009046_muscle_twitch1.90064885
26MP0003115_abnormal_respiratory_system1.83864344
27MP0002184_abnormal_innervation1.82024756
28MP0010030_abnormal_orbit_morphology1.81700331
29MP0000569_abnormal_digit_pigmentation1.77323466
30MP0005275_abnormal_skin_tensile1.75157220
31MP0005423_abnormal_somatic_nervous1.75080933
32MP0002932_abnormal_joint_morphology1.68318080
33MP0002896_abnormal_bone_mineralization1.65908685
34MP0004811_abnormal_neuron_physiology1.65004551
35MP0005187_abnormal_penis_morphology1.64012778
36MP0000762_abnormal_tongue_morphology1.63611840
37MP0003283_abnormal_digestive_organ1.60738879
38MP0001968_abnormal_touch/_nociception1.60532703
39MP0002909_abnormal_adrenal_gland1.58499243
40MP0002735_abnormal_chemical_nociception1.57787720
41MP0005499_abnormal_olfactory_system1.57307244
42MP0005394_taste/olfaction_phenotype1.57307244
43MP0000462_abnormal_digestive_system1.56430645
44MP0002272_abnormal_nervous_system1.51976948
45MP0004858_abnormal_nervous_system1.51832757
46MP0002557_abnormal_social/conspecific_i1.50766565
47MP0006072_abnormal_retinal_apoptosis1.50631948
48MP0002234_abnormal_pharynx_morphology1.47814687
49MP0001502_abnormal_circadian_rhythm1.47628970
50MP0005508_abnormal_skeleton_morphology1.46285211
51MP0002067_abnormal_sensory_capabilities1.45880606
52MP0002882_abnormal_neuron_morphology1.45290673
53MP0008569_lethality_at_weaning1.45162905
54MP0002090_abnormal_vision1.43996385
55MP0008789_abnormal_olfactory_epithelium1.43505906
56MP0003122_maternal_imprinting1.40480945
57MP0003091_abnormal_cell_migration1.38840111
58MP0003329_amyloid_beta_deposits1.35923594
59MP0000955_abnormal_spinal_cord1.31109902
60MP0001879_abnormal_lymphatic_vessel1.30178034
61MP0006292_abnormal_olfactory_placode1.30157842
62MP0004510_myositis1.29823670
63MP0000428_abnormal_craniofacial_morphol1.28817107
64MP0005503_abnormal_tendon_morphology1.28262450
65MP0003191_abnormal_cellular_cholesterol1.28063648
66MP0001501_abnormal_sleep_pattern1.27819672
67MP0004885_abnormal_endolymph1.27596691
68MP0001177_atelectasis1.26440583
69MP0009384_cardiac_valve_regurgitation1.24430107
70MP0002116_abnormal_craniofacial_bone1.21621709
71MP0000751_myopathy1.21325085
72MP0005646_abnormal_pituitary_gland1.19800978
73MP0002653_abnormal_ependyma_morphology1.16237097
74MP0005386_behavior/neurological_phenoty1.15756469
75MP0004924_abnormal_behavior1.15756469
76MP0004215_abnormal_myocardial_fiber1.15389990
77MP0002152_abnormal_brain_morphology1.11767078
78MP0002108_abnormal_muscle_morphology1.11469428
79MP0004145_abnormal_muscle_electrophysio1.10969513
80MP0000534_abnormal_ureter_morphology1.10846893
81MP0002736_abnormal_nociception_after1.10136904
82MP0001958_emphysema1.09970288
83MP0001970_abnormal_pain_threshold1.09908554
84MP0000759_abnormal_skeletal_muscle1.08533069
85MP0000749_muscle_degeneration1.07654466
86MP0000631_abnormal_neuroendocrine_gland1.07056915
87MP0005253_abnormal_eye_physiology1.06048942
88MP0005248_abnormal_Harderian_gland1.06005922
89MP0001340_abnormal_eyelid_morphology1.05860666
90MP0002249_abnormal_larynx_morphology1.05112799
91MP0002177_abnormal_outer_ear1.03999429
92MP0005171_absent_coat_pigmentation1.03702084
93MP0000537_abnormal_urethra_morphology1.03613667
94MP0000767_abnormal_smooth_muscle1.02989050
95MP0000579_abnormal_nail_morphology1.02886243
96MP0002796_impaired_skin_barrier1.02825266
97MP0000613_abnormal_salivary_gland1.01711045
98MP0002060_abnormal_skin_morphology1.00796246
99MP0003385_abnormal_body_wall0.99743455
100MP0005623_abnormal_meninges_morphology0.99197648
101MP0003633_abnormal_nervous_system0.98548681
102MP0000013_abnormal_adipose_tissue0.98414204
103MP0002114_abnormal_axial_skeleton0.97927071
104MP0003787_abnormal_imprinting0.97841582
105MP0003941_abnormal_skin_development0.96462873
106MP0002752_abnormal_somatic_nervous0.95614117
107MP0003890_abnormal_embryonic-extraembry0.94741444
108MP0005197_abnormal_uvea_morphology0.94333175
109MP0005195_abnormal_posterior_eye0.94130440
110MP0001440_abnormal_grooming_behavior0.93263797
111MP0010368_abnormal_lymphatic_system0.93178051
112MP0004085_abnormal_heartbeat0.92544107
113MP0009053_abnormal_anal_canal0.92448570
114MP0000003_abnormal_adipose_tissue0.92419581
115MP0002066_abnormal_motor_capabilities/c0.92208530
116MP0002733_abnormal_thermal_nociception0.91617499
117MP0003861_abnormal_nervous_system0.91461463
118MP0001346_abnormal_lacrimal_gland0.91455054
119MP0005058_abnormal_lysosome_morphology0.90863092
120MP0000750_abnormal_muscle_regeneration0.90562649
121MP0002938_white_spotting0.90166475
122MP0004134_abnormal_chest_morphology0.88399805
123MP0000163_abnormal_cartilage_morphology0.88350744
124MP0009672_abnormal_birth_weight0.88031783
125MP0000432_abnormal_head_morphology0.87967288
126MP0003137_abnormal_impulse_conducting0.87247595
127MP0003935_abnormal_craniofacial_develop0.86780565
128MP0001188_hyperpigmentation0.86161801
129MP0003634_abnormal_glial_cell0.85370623
130MP0010386_abnormal_urinary_bladder0.82697364
131MP0002233_abnormal_nose_morphology0.82303069
132MP0003045_fibrosis0.81633633
133MP0003279_aneurysm0.80910656
134MP0002295_abnormal_pulmonary_circulatio0.80408926
135MP0003631_nervous_system_phenotype0.80276942
136MP0001270_distended_abdomen0.80177457
137MP0002229_neurodegeneration0.79763470
138MP0004087_abnormal_muscle_fiber0.78361078
139MP0003938_abnormal_ear_development0.77823418
140MP0002697_abnormal_eye_size0.77548943
141MP0004272_abnormal_basement_membrane0.77306890
142MP0009250_abnormal_appendicular_skeleto0.76682909
143MP0003121_genomic_imprinting0.76089391
144MP0003183_abnormal_peptide_metabolism0.75758443
145MP0005409_darkened_coat_color0.75484322
146MP0000566_synostosis0.75173981
147MP0001849_ear_inflammation0.75165201
148MP0005645_abnormal_hypothalamus_physiol0.74971592
149MP0003755_abnormal_palate_morphology0.73808734
150MP0002332_abnormal_exercise_endurance0.73710526
151MP0000049_abnormal_middle_ear0.73706023
152MP0000747_muscle_weakness0.73305039
153MP0002113_abnormal_skeleton_development0.71874296
154MP0004133_heterotaxia0.71830670
155MP0002109_abnormal_limb_morphology0.69489051
156MP0003119_abnormal_digestive_system0.69209112
157MP0002115_abnormal_skeleton_extremities0.68926994
158MP0003950_abnormal_plasma_membrane0.67905834
159MP0003879_abnormal_hair_cell0.67033253
160MP0010352_gastrointestinal_tract_polyps0.66471010
161MP0001243_abnormal_dermal_layer0.65789630
162MP0001175_abnormal_lung_morphology0.65389023

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.22055276
2Congenital stationary night blindness (HP:0007642)4.02299321
3Central scotoma (HP:0000603)3.84720080
4Focal motor seizures (HP:0011153)3.61282301
5Epileptic encephalopathy (HP:0200134)3.45312350
6Progressive cerebellar ataxia (HP:0002073)3.41480451
7Broad face (HP:0000283)3.26772406
8Cervical subluxation (HP:0003308)3.17282128
9Action tremor (HP:0002345)3.16682141
10Febrile seizures (HP:0002373)3.09102554
11Focal seizures (HP:0007359)3.04689311
12Genetic anticipation (HP:0003743)3.02220711
13Atrophic scars (HP:0001075)3.00805248
14Aortic dissection (HP:0002647)2.96437124
15Myokymia (HP:0002411)2.84231543
16Short nail (HP:0001799)2.82348208
17Abnormality of macular pigmentation (HP:0008002)2.70030302
18Scotoma (HP:0000575)2.68959088
19Dysmetric saccades (HP:0000641)2.68591935
20Lip pit (HP:0100267)2.64687376
21Vertebral compression fractures (HP:0002953)2.62375202
22Osteolytic defects of the phalanges of the hand (HP:0009771)2.48349064
23Osteolytic defects of the hand bones (HP:0009699)2.48349064
24Prolonged QT interval (HP:0001657)2.48188294
25Excessive salivation (HP:0003781)2.47075621
26Drooling (HP:0002307)2.47075621
27Gaze-evoked nystagmus (HP:0000640)2.42884559
28Absence seizures (HP:0002121)2.40460117
29Natal tooth (HP:0000695)2.36163306
30Truncal ataxia (HP:0002078)2.34926291
31Atrioventricular block (HP:0001678)2.30403165
32Short 4th metacarpal (HP:0010044)2.29948788
33Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.29948788
34Spinal rigidity (HP:0003306)2.27736923
35Infantile muscular hypotonia (HP:0008947)2.25119007
36Urethral obstruction (HP:0000796)2.23107833
37Macroorchidism (HP:0000053)2.21434147
38Elfin facies (HP:0004428)2.18594937
39Obstructive sleep apnea (HP:0002870)2.17607240
40Visual hallucinations (HP:0002367)2.16665996
41Wormian bones (HP:0002645)2.16042839
42Dysdiadochokinesis (HP:0002075)2.16038094
43Termporal pattern (HP:0011008)2.15179673
44Insidious onset (HP:0003587)2.15179673
45Neoplasm of the heart (HP:0100544)2.14368059
46Glucose intolerance (HP:0000833)2.13389882
47Broad-based gait (HP:0002136)2.12177074
48Abnormality of the distal phalanges of the toes (HP:0010182)2.12093650
49Shallow orbits (HP:0000586)2.11439954
50Long toe (HP:0010511)2.11319817
51Advanced eruption of teeth (HP:0006288)2.09945091
52Scanning speech (HP:0002168)2.09744596
53Asymmetry of the thorax (HP:0001555)2.09724954
54Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.08712844
55Atonic seizures (HP:0010819)2.08645823
56Back pain (HP:0003418)2.08063841
57Aplasia involving bones of the extremities (HP:0009825)2.07655326
58Aplasia involving bones of the upper limbs (HP:0009823)2.07655326
59Aplasia of the phalanges of the hand (HP:0009802)2.07655326
60Dialeptic seizures (HP:0011146)2.06609743
61Abnormal EKG (HP:0003115)2.04277847
62Fragile skin (HP:0001030)2.03409834
63Distal lower limb amyotrophy (HP:0008944)2.02848079
64Postural instability (HP:0002172)2.02367051
65Epileptiform EEG discharges (HP:0011182)2.01494734
66Generalized tonic-clonic seizures (HP:0002069)2.00534230
67Lower limb amyotrophy (HP:0007210)2.00489840
68Obsessive-compulsive behavior (HP:0000722)1.99875258
69EEG with generalized epileptiform discharges (HP:0011198)1.98569921
70Abnormality of dentin (HP:0010299)1.98091405
71Primary atrial arrhythmia (HP:0001692)1.98064936
72Urinary bladder sphincter dysfunction (HP:0002839)1.96368250
73Ankle contracture (HP:0006466)1.96153739
74Abnormality of the distal phalanx of the thumb (HP:0009617)1.95988368
75Blue sclerae (HP:0000592)1.94178118
76Hyperventilation (HP:0002883)1.94164845
77Abnormality of the 4th metacarpal (HP:0010012)1.93667716
78Aqueductal stenosis (HP:0002410)1.93381382
79Spinal cord compression (HP:0002176)1.92543180
80Distal upper limb amyotrophy (HP:0007149)1.91471619
81Upper limb amyotrophy (HP:0009129)1.91471619
82Megalencephaly (HP:0001355)1.91140251
83Mitral valve prolapse (HP:0001634)1.90210203
84Hyperacusis (HP:0010780)1.88396581
85Renovascular hypertension (HP:0100817)1.88177968
86Hand muscle atrophy (HP:0009130)1.87982403
87Widely spaced teeth (HP:0000687)1.87814119
88Hyperextensible skin (HP:0000974)1.87052854
89Bronchomalacia (HP:0002780)1.87042117
90Nuclear cataract (HP:0100018)1.86404618
91Absent speech (HP:0001344)1.86313955
92Severe visual impairment (HP:0001141)1.86018676
93Trigonocephaly (HP:0000243)1.85835768
94Abnormal atrioventricular conduction (HP:0005150)1.85165684
95Blue irides (HP:0000635)1.84015819
96Neurofibrillary tangles (HP:0002185)1.83665952
97Renal duplication (HP:0000075)1.83583564
98Sparse lateral eyebrow (HP:0005338)1.82945817
99Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.82452728
100Distal lower limb muscle weakness (HP:0009053)1.82375739
101Atrial fibrillation (HP:0005110)1.81211618
102Impaired smooth pursuit (HP:0007772)1.80941101
103Cerebral aneurysm (HP:0004944)1.80919347
104Supraventricular tachycardia (HP:0004755)1.80529709
105Cardiovascular calcification (HP:0011915)1.79266124
106Flat acetabular roof (HP:0003180)1.78625224
107Supraventricular arrhythmia (HP:0005115)1.78150722
108Soft skin (HP:0000977)1.77980028
109Hypsarrhythmia (HP:0002521)1.77934537
110Arterial tortuosity (HP:0005116)1.77877409
111Broad metatarsal (HP:0001783)1.77162538
112Flat cornea (HP:0007720)1.76906475
113Atrioventricular canal defect (HP:0006695)1.76472116
114Pointed chin (HP:0000307)1.75474805
115Depression (HP:0000716)1.75240319
116Mitral stenosis (HP:0001718)1.74307165
117Neonatal short-limb short stature (HP:0008921)1.73099758
118Deviation of the thumb (HP:0009603)1.72878979
119Abnormality of the sella turcica (HP:0002679)1.72604955
120Vascular calcification (HP:0004934)1.71611063
121Insomnia (HP:0100785)1.71001125
122Cutaneous finger syndactyly (HP:0010554)1.70849580
123Long palpebral fissure (HP:0000637)1.70364612
124Ankle clonus (HP:0011448)1.70263361
125Abnormal ossification of hand bones (HP:0005921)1.70240011
126Midline defect of the nose (HP:0004122)1.70110427
127Deformed sella turcica (HP:0002681)1.70069389
128Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.69813580
129Narrow palate (HP:0000189)1.69281716
130Abnormal social behavior (HP:0012433)1.69125111
131Impaired social interactions (HP:0000735)1.69125111
132Microglossia (HP:0000171)1.68912888
133Bowel diverticulosis (HP:0005222)1.68235831
134Narrow nasal bridge (HP:0000446)1.68055488
135Poor eye contact (HP:0000817)1.67208787
136Arnold-Chiari malformation (HP:0002308)1.66723439
137Protrusio acetabuli (HP:0003179)1.66187541
138Mildly elevated creatine phosphokinase (HP:0008180)1.65928232
139Thin bony cortex (HP:0002753)1.64854453
140Mutism (HP:0002300)1.64706667
141Overgrowth (HP:0001548)1.63930288
142Joint laxity (HP:0001388)1.63574682
143Proximal placement of thumb (HP:0009623)1.63559512
144Right ventricular cardiomyopathy (HP:0011663)1.63257922
145Hepatoblastoma (HP:0002884)1.61201636
146Hemiparesis (HP:0001269)1.61016663
147Dysmetria (HP:0001310)1.60684926
148Bladder diverticulum (HP:0000015)1.60652624
149Abnormality of ocular smooth pursuit (HP:0000617)1.60519921
150Exostoses (HP:0100777)1.60096218
151Hypoventilation (HP:0002791)1.60051423
152Vascular tortuosity (HP:0004948)1.59749838
153Midface retrusion (HP:0011800)1.59661724
154Overriding aorta (HP:0002623)1.58893573
155Open mouth (HP:0000194)1.57875954
156Abnormality of the diencephalon (HP:0010662)1.57530575
157Elbow flexion contracture (HP:0002987)1.57503703
158Spondylolisthesis (HP:0003302)1.57275760
159Osteopenia (HP:0000938)1.56523318
160Hemiplegia (HP:0002301)1.55870297
161Spinal cord lesions (HP:0100561)1.55035813
162Syringomyelia (HP:0003396)1.55035813
163Cubitus valgus (HP:0002967)1.54709151
164Abnormality of salivation (HP:0100755)1.54546432
165Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.54334113
166Cerebral inclusion bodies (HP:0100314)1.54081251
167Calcaneovalgus deformity (HP:0001848)1.53286419
168Hypoplasia of the maxilla (HP:0000327)1.53242589
169Papillary thyroid carcinoma (HP:0002895)1.53115232
170Ankyloglossia (HP:0010296)1.52331190
171Abnormality of skull ossification (HP:0002703)1.51507384
172Abnormality of the phalanges of the hallux (HP:0010057)1.51285535
173Abnormality of the calf musculature (HP:0001430)1.50607317
174Follicular hyperkeratosis (HP:0007502)1.50380877
175Progressive sensorineural hearing impairment (HP:0000408)1.50073008
176Hallux valgus (HP:0001822)1.50061206
177Labial hypoplasia (HP:0000066)1.50025914
178Abnormal eating behavior (HP:0100738)1.49395688
179Hydroureter (HP:0000072)1.48952490

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK14.04173830
2TRIB33.38416037
3MARK13.37020792
4PRKD33.23316080
5NTRK32.87637340
6MAP3K42.73367042
7LIMK12.71000058
8EPHA22.65799989
9PAK62.51151215
10MAP3K92.49064110
11EPHA42.36410726
12MINK12.25814110
13NTRK22.25217191
14TESK22.18673968
15INSRR2.04848694
16PKN21.99656776
17KSR11.80041570
18CAMK1G1.74644055
19SCYL21.73903377
20MET1.73294002
21ERN11.61552156
22SIK31.59807585
23ERBB41.57531499
24EPHB21.56946749
25TAOK21.56684856
26DAPK21.56632729
27MAP2K71.47151816
28PHKG11.46794624
29PHKG21.46794624
30TRPM71.44623850
31MAP2K41.35293094
32STK381.34077775
33FGFR21.31095955
34MAPK131.30861608
35CAMK1D1.29927520
36CDK51.24710453
37DMPK1.23477730
38SGK21.22881883
39SIK11.22474029
40PAK31.20912707
41WNK31.20629683
42TNIK1.20498170
43SGK2231.18446750
44SGK4941.18446750
45MST1R1.18242008
46RIPK11.18240766
47CAMKK11.16666728
48PRKCH1.13803089
49NTRK11.11450720
50FRK1.10832606
51PRPF4B1.10617438
52TTN1.09575155
53FGFR41.09277000
54UHMK11.08981651
55DDR21.08423933
56CASK1.08022131
57VRK21.07213696
58PDGFRA1.06565572
59SGK31.05398816
60ERBB21.03570845
61TRIM281.03288837
62MOS0.99093164
63CSNK1G30.98399038
64PAK40.95152013
65MUSK0.94472653
66CAMK10.94066292
67MAP3K60.91912980
68MYLK0.90498389
69FER0.90294942
70ERBB30.88099832
71PRKD20.88077023
72WNK10.87898105
73DYRK1A0.87636942
74PRKCG0.87223556
75LATS10.86884267
76SMG10.84289252
77PNCK0.82215751
78PAK20.81708699
79SIK20.80793654
80MARK20.78945596
81AKT30.77919145
82DAPK10.77317628
83CAMKK20.77116461
84CSNK1G20.76936209
85HIPK20.75667774
86PINK10.75606110
87CAMK2A0.75429431
88SGK10.73864253
89PLK20.73831446
90CDK180.73663586
91KSR20.73396724
92NEK60.73060522
93CSNK1G10.72308861
94PRKCE0.71487389
95CAMK40.71437348
96CDK140.70524995
97BMX0.70477201
98FGFR10.70243171
99PDGFRB0.69213942
100ROCK10.67925679
101CDC42BPA0.67262469
102STK38L0.67159934
103CDK150.66192973
104MAP3K70.66035724
105MAP2K60.64182098
106CDK120.64050389
107RET0.64033594
108ARAF0.63475887
109EPHA30.63399170
110ROCK20.61591165
111BRD40.61116246
112LATS20.60630955
113NEK90.60447492
114CDK70.59005339
115MAPK100.58426029
116EPHB10.58300805
117RPS6KA30.57588274
118MAP3K120.57370708
119NME20.57218743
120PTK20.57077920
121CSNK1A1L0.56929605
122CDK30.56311495
123SRPK10.54896571
124CAMK2B0.54615946
125BCR0.54604600
126MTOR0.53520122
127CDK11A0.53266302
128ICK0.53149088
129PRKCZ0.52944091
130LMTK20.51311756
131STK110.51164787
132TYRO30.51138343
133MAP3K20.49720550
134PTK2B0.49498273
135PIM20.49182589
136CAMK2G0.48355690
137MAPK80.47646011
138CAMK2D0.47085692
139EEF2K0.45462678
140MAPKAPK30.45257972
141PTK60.43961109
142RPS6KA20.41642172
143MAPK90.40601309
144DYRK1B0.39959455
145CDK90.37492358

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.75613009
2Circadian entrainment_Homo sapiens_hsa047132.53346184
3GABAergic synapse_Homo sapiens_hsa047272.40253388
4Synaptic vesicle cycle_Homo sapiens_hsa047212.38783859
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.28851455
6Insulin secretion_Homo sapiens_hsa049112.22087904
7Morphine addiction_Homo sapiens_hsa050322.14814731
8Glutamatergic synapse_Homo sapiens_hsa047242.11754738
9Olfactory transduction_Homo sapiens_hsa047401.92128589
10Long-term potentiation_Homo sapiens_hsa047201.86340050
11Dopaminergic synapse_Homo sapiens_hsa047281.83394723
12Aldosterone synthesis and secretion_Homo sapiens_hsa049251.83327838
13Phototransduction_Homo sapiens_hsa047441.78382272
14Amphetamine addiction_Homo sapiens_hsa050311.77765990
15Cholinergic synapse_Homo sapiens_hsa047251.71617839
16Salivary secretion_Homo sapiens_hsa049701.68661987
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.65611759
18Renin secretion_Homo sapiens_hsa049241.59160040
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.58665487
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.56886877
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.55512851
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53214197
23Type II diabetes mellitus_Homo sapiens_hsa049301.52894259
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.52812240
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.52386956
26Dilated cardiomyopathy_Homo sapiens_hsa054141.51022626
27Thyroid cancer_Homo sapiens_hsa052161.49981518
28Axon guidance_Homo sapiens_hsa043601.46818959
29Cocaine addiction_Homo sapiens_hsa050301.45862079
30Serotonergic synapse_Homo sapiens_hsa047261.44210752
31Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.40570874
32Oxytocin signaling pathway_Homo sapiens_hsa049211.40063750
33Gap junction_Homo sapiens_hsa045401.39429157
34cAMP signaling pathway_Homo sapiens_hsa040241.37495769
35Gastric acid secretion_Homo sapiens_hsa049711.34188271
36GnRH signaling pathway_Homo sapiens_hsa049121.33109647
37Calcium signaling pathway_Homo sapiens_hsa040201.28270805
38Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.25400033
39Taste transduction_Homo sapiens_hsa047421.23388999
40Long-term depression_Homo sapiens_hsa047301.19878847
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.17810981
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17666576
43Glioma_Homo sapiens_hsa052141.17263249
44Notch signaling pathway_Homo sapiens_hsa043301.13812648
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10155891
46ErbB signaling pathway_Homo sapiens_hsa040121.09670049
47Lysine degradation_Homo sapiens_hsa003101.09191659
48Melanogenesis_Homo sapiens_hsa049161.04730699
49Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04195394
50MicroRNAs in cancer_Homo sapiens_hsa052061.00991887
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00967626
52Pancreatic cancer_Homo sapiens_hsa052121.00002496
53Estrogen signaling pathway_Homo sapiens_hsa049150.99247259
54N-Glycan biosynthesis_Homo sapiens_hsa005100.98385729
55AMPK signaling pathway_Homo sapiens_hsa041520.98279445
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96118714
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95240059
58Bladder cancer_Homo sapiens_hsa052190.94521348
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94148411
60Circadian rhythm_Homo sapiens_hsa047100.93217469
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92386144
62Fatty acid elongation_Homo sapiens_hsa000620.91937506
63mTOR signaling pathway_Homo sapiens_hsa041500.91491567
64Endometrial cancer_Homo sapiens_hsa052130.91461094
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.90502757
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.89200679
67Rap1 signaling pathway_Homo sapiens_hsa040150.88138150
68Nitrogen metabolism_Homo sapiens_hsa009100.87779887
69Small cell lung cancer_Homo sapiens_hsa052220.87614771
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84781933
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84514015
72Wnt signaling pathway_Homo sapiens_hsa043100.84395840
73Dorso-ventral axis formation_Homo sapiens_hsa043200.83715848
74MAPK signaling pathway_Homo sapiens_hsa040100.82778701
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82459807
76Basal cell carcinoma_Homo sapiens_hsa052170.81786235
77Colorectal cancer_Homo sapiens_hsa052100.80743375
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79959992
79Biosynthesis of amino acids_Homo sapiens_hsa012300.77762285
80Pancreatic secretion_Homo sapiens_hsa049720.77299740
81TGF-beta signaling pathway_Homo sapiens_hsa043500.76552212
82Pathways in cancer_Homo sapiens_hsa052000.76318897
83Prostate cancer_Homo sapiens_hsa052150.76230239
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.75638196
85Renal cell carcinoma_Homo sapiens_hsa052110.74918974
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.74411238
87Choline metabolism in cancer_Homo sapiens_hsa052310.74240280
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73979323
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73779971
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73627680
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73536293
92Pentose phosphate pathway_Homo sapiens_hsa000300.71038858
93Hippo signaling pathway_Homo sapiens_hsa043900.70935952
94Vitamin B6 metabolism_Homo sapiens_hsa007500.70165396
95Fatty acid biosynthesis_Homo sapiens_hsa000610.69589986
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68924070
97Glucagon signaling pathway_Homo sapiens_hsa049220.68695431
98Proteoglycans in cancer_Homo sapiens_hsa052050.68531841
99Hedgehog signaling pathway_Homo sapiens_hsa043400.68429547
100Ras signaling pathway_Homo sapiens_hsa040140.68278925
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67265130
102Focal adhesion_Homo sapiens_hsa045100.65620862
103Adherens junction_Homo sapiens_hsa045200.64921286
104Thyroid hormone synthesis_Homo sapiens_hsa049180.63985335
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63751283
106Oocyte meiosis_Homo sapiens_hsa041140.62333404
107Alcoholism_Homo sapiens_hsa050340.59383479
108Steroid biosynthesis_Homo sapiens_hsa001000.59372707
109Sphingolipid metabolism_Homo sapiens_hsa006000.58918157
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58029969
111Protein digestion and absorption_Homo sapiens_hsa049740.56602740
112Amoebiasis_Homo sapiens_hsa051460.56170652
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56165846
114Vibrio cholerae infection_Homo sapiens_hsa051100.55788870
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55457078
116Fatty acid metabolism_Homo sapiens_hsa012120.55410825
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.54557345
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53830637
119Insulin signaling pathway_Homo sapiens_hsa049100.53517869
120ECM-receptor interaction_Homo sapiens_hsa045120.52449257
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.50763027
122VEGF signaling pathway_Homo sapiens_hsa043700.50379727
123Tight junction_Homo sapiens_hsa045300.49435776
124Cardiac muscle contraction_Homo sapiens_hsa042600.49355751
125Bile secretion_Homo sapiens_hsa049760.48984680
126Collecting duct acid secretion_Homo sapiens_hsa049660.48769080
127Non-small cell lung cancer_Homo sapiens_hsa052230.48191821
128Inositol phosphate metabolism_Homo sapiens_hsa005620.47991613
129Melanoma_Homo sapiens_hsa052180.47964510
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47327878
131Endocytosis_Homo sapiens_hsa041440.46797218
132Ovarian steroidogenesis_Homo sapiens_hsa049130.45979199
133AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45878411
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45544341
135Chronic myeloid leukemia_Homo sapiens_hsa052200.43167403

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