PCDHGB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin biosynthetic process (GO:0042438)5.73018086
2postsynaptic membrane organization (GO:0001941)5.27102738
3melanin metabolic process (GO:0006582)5.06120903
4dermatan sulfate biosynthetic process (GO:0030208)4.81056432
5dermatan sulfate metabolic process (GO:0030205)4.75726733
6secondary metabolite biosynthetic process (GO:0044550)4.51821116
7synaptic vesicle maturation (GO:0016188)4.36665942
8locomotory exploration behavior (GO:0035641)4.16028340
9chondroitin sulfate catabolic process (GO:0030207)4.10983520
10regulation of short-term neuronal synaptic plasticity (GO:0048172)3.90166046
11positive regulation of osteoblast proliferation (GO:0033690)3.78030716
12sodium ion export (GO:0071436)3.60335547
13layer formation in cerebral cortex (GO:0021819)3.50946827
14membrane assembly (GO:0071709)3.50226041
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.50197903
16presynaptic membrane assembly (GO:0097105)3.46410864
17cellular potassium ion homeostasis (GO:0030007)3.43209064
18cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.39720759
19astrocyte differentiation (GO:0048708)3.38701740
20synaptic vesicle docking involved in exocytosis (GO:0016081)3.37965106
21establishment of nucleus localization (GO:0040023)3.32857111
22plasma membrane repair (GO:0001778)3.31918975
23membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.31561366
24eye photoreceptor cell differentiation (GO:0001754)3.28134979
25photoreceptor cell differentiation (GO:0046530)3.28134979
26regulation of synapse structural plasticity (GO:0051823)3.27569756
27cell communication by electrical coupling (GO:0010644)3.26793089
28activation of protein kinase A activity (GO:0034199)3.25776645
29chondroitin sulfate biosynthetic process (GO:0030206)3.21066628
30dendrite morphogenesis (GO:0048813)3.19196525
31positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.19038947
32cytoskeletal anchoring at plasma membrane (GO:0007016)3.17453443
33myelination in peripheral nervous system (GO:0022011)3.14491185
34peripheral nervous system axon ensheathment (GO:0032292)3.14491185
35protein retention in ER lumen (GO:0006621)3.11895371
36potassium ion import (GO:0010107)3.11673271
37vocalization behavior (GO:0071625)3.06607742
38nephron tubule formation (GO:0072079)3.05697046
39amino acid import (GO:0043090)3.05288477
40neuron cell-cell adhesion (GO:0007158)3.00050887
41maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.99744567
42cerebellar Purkinje cell layer development (GO:0021680)2.92257783
43presynaptic membrane organization (GO:0097090)2.92218630
44regulation of axon guidance (GO:1902667)2.90556534
45regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.89975827
46regulation of extracellular matrix disassembly (GO:0010715)2.84843852
47negative regulation of myoblast differentiation (GO:0045662)2.84691169
48glutamate secretion (GO:0014047)2.82874756
49synaptic vesicle exocytosis (GO:0016079)2.80465464
50neuromuscular process controlling balance (GO:0050885)2.80431751
51positive regulation of fibroblast migration (GO:0010763)2.80121288
52exploration behavior (GO:0035640)2.77177486
53nerve growth factor signaling pathway (GO:0038180)2.75855017
54camera-type eye morphogenesis (GO:0048593)2.74494950
55stress fiber assembly (GO:0043149)2.73117110
56positive regulation of synapse maturation (GO:0090129)2.72345144
57negative regulation of axon extension involved in axon guidance (GO:0048843)2.71212433
58skin morphogenesis (GO:0043589)2.71021386
59regulation of ARF protein signal transduction (GO:0032012)2.70442398
60dendritic spine morphogenesis (GO:0060997)2.69563112
61axonal fasciculation (GO:0007413)2.69355693
62regulation of glutamate receptor signaling pathway (GO:1900449)2.69158219
63astrocyte development (GO:0014002)2.68503084
64regulation of synaptic vesicle exocytosis (GO:2000300)2.66224562
65L-amino acid import (GO:0043092)2.66013528
66import into cell (GO:0098657)2.65711486
67regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.65220253
68type B pancreatic cell proliferation (GO:0044342)2.64407958
69cerebellar Purkinje cell differentiation (GO:0021702)2.59686497
70vascular endothelial growth factor signaling pathway (GO:0038084)2.58899543
71positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.58074103
72semaphorin-plexin signaling pathway (GO:0071526)2.57269404
73neuron projection extension involved in neuron projection guidance (GO:1902284)2.57020125
74axon extension involved in axon guidance (GO:0048846)2.57020125
75regulation of long-term neuronal synaptic plasticity (GO:0048169)2.56649032
76calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.55731164
77neuron projection regeneration (GO:0031102)2.53117460
78regulation of neuronal synaptic plasticity (GO:0048168)2.51730368
79positive regulation of axon extension (GO:0045773)2.50525967
80cell communication involved in cardiac conduction (GO:0086065)2.50481003
81negative regulation of chondrocyte differentiation (GO:0032331)2.50340729
82response to auditory stimulus (GO:0010996)2.49879113
83proline transport (GO:0015824)2.49104396
84neurotransmitter secretion (GO:0007269)2.48532860
85neurotransmitter-gated ion channel clustering (GO:0072578)2.47759829
86negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.47618166
87developmental induction (GO:0031128)2.47513378
88adherens junction assembly (GO:0034333)2.47086831
89cerebellar granule cell differentiation (GO:0021707)2.45755757
90barbed-end actin filament capping (GO:0051016)2.44456067
91cell-substrate junction assembly (GO:0007044)2.44422492
92cellular sodium ion homeostasis (GO:0006883)2.44218478
93regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.44211436
94regulation of dendritic spine morphogenesis (GO:0061001)2.44057299
95auditory behavior (GO:0031223)2.43879686
96protein targeting to plasma membrane (GO:0072661)2.43313218
97insulin-like growth factor receptor signaling pathway (GO:0048009)2.42412031
98clathrin coat assembly (GO:0048268)2.42320229
99ionotropic glutamate receptor signaling pathway (GO:0035235)2.40693957
100regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.40057692
101regulation of glucose import in response to insulin stimulus (GO:2001273)2.40020592
102hemidesmosome assembly (GO:0031581)2.39405577
103protein localization to synapse (GO:0035418)2.39233875
104cell volume homeostasis (GO:0006884)2.39041172
105chondroitin sulfate metabolic process (GO:0030204)2.38598682
106coronary vasculature morphogenesis (GO:0060977)2.38215727
107negative regulation of vascular permeability (GO:0043116)2.37325798
108cortical actin cytoskeleton organization (GO:0030866)2.35866477
109muscle cell migration (GO:0014812)2.34772389
110potassium ion homeostasis (GO:0055075)2.34705768
111focal adhesion assembly (GO:0048041)2.34357403
112cell-substrate adherens junction assembly (GO:0007045)2.34357403
113regulation of osteoblast proliferation (GO:0033688)2.34342096
114protein localization to endosome (GO:0036010)2.33900823
115response to pheromone (GO:0019236)2.33426451
116endothelial cell chemotaxis (GO:0035767)2.33141176
117membrane depolarization during action potential (GO:0086010)2.32202230
118positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.32041647
119cell-cell junction maintenance (GO:0045217)2.31374024
120regulation of membrane repolarization (GO:0060306)2.31320800
121regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.30904615
122regulation of synaptic vesicle transport (GO:1902803)2.30319502
123cell-cell signaling involved in cell fate commitment (GO:0045168)2.30000661
124regulation of axon extension involved in axon guidance (GO:0048841)2.29884107
125alanine transport (GO:0032328)2.29663064
126endothelial cell morphogenesis (GO:0001886)2.29471792
127cAMP biosynthetic process (GO:0006171)2.29132430
128synapse assembly (GO:0007416)2.28778111
129vesicle transport along microtubule (GO:0047496)2.28488490
130dendritic spine organization (GO:0097061)2.27282459
131neuron recognition (GO:0008038)2.27279701
132retina vasculature morphogenesis in camera-type eye (GO:0061299)2.26978861
133myotube differentiation (GO:0014902)2.26792557
134COPI coating of Golgi vesicle (GO:0048205)2.26781747
135Golgi transport vesicle coating (GO:0048200)2.26781747
136actin filament depolymerization (GO:0030042)2.26527898
137regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.26440042
138glycine transport (GO:0015816)2.26381654
139regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.26275404
140glutamate receptor signaling pathway (GO:0007215)2.26272245
141cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.26025219
142oligodendrocyte differentiation (GO:0048709)2.25674566
143peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.24853123
144gamma-aminobutyric acid transport (GO:0015812)2.24836507
145basement membrane organization (GO:0071711)2.24297914
146cortical cytoskeleton organization (GO:0030865)2.24061798
147substrate-dependent cell migration (GO:0006929)2.23699877
148negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.23391273
149positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.23071315
150positive regulation of dendritic spine morphogenesis (GO:0061003)2.22424114
151long-term memory (GO:0007616)2.22388435
152innervation (GO:0060384)2.21088894
153membrane repolarization (GO:0086009)2.20996565
154ensheathment of neurons (GO:0007272)2.20840800
155axon ensheathment (GO:0008366)2.20840800
156regulation of ARF GTPase activity (GO:0032312)2.19973794
157regulation of excitatory postsynaptic membrane potential (GO:0060079)2.19918666
158axon extension (GO:0048675)2.19190746
159paraxial mesoderm development (GO:0048339)2.18585061
160positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.18068141
161negative regulation of fatty acid transport (GO:2000192)2.18039298
162synaptic transmission, glutamatergic (GO:0035249)2.18006607
163negative regulation of cytosolic calcium ion concentration (GO:0051481)2.17476061
164chondrocyte proliferation (GO:0035988)2.16908421
165negative regulation of catenin import into nucleus (GO:0035414)2.16127937
166membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.15399112
167protein targeting to Golgi (GO:0000042)2.14838170
168cell adhesion mediated by integrin (GO:0033627)2.14259832

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.35104803
2TP63_17297297_ChIP-ChIP_HaCaT_Human2.52260043
3DROSHA_22980978_ChIP-Seq_HELA_Human2.46339886
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.31225737
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.15704611
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.15704611
7GBX2_23144817_ChIP-Seq_PC3_Human2.14824921
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.13379086
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.04224692
10* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.98312132
11JARID2_20064375_ChIP-Seq_MESCs_Mouse1.91474211
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91180210
13STAT6_21828071_ChIP-Seq_BEAS2B_Human1.90920760
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.88637137
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87628013
16JARID2_20075857_ChIP-Seq_MESCs_Mouse1.87036931
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.85294140
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84474253
19TRIM28_21343339_ChIP-Seq_HEK293_Human1.83325780
20ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.81265493
21RARB_27405468_Chip-Seq_BRAIN_Mouse1.80472573
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.78555639
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78229331
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.77455332
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76539263
26EP300_21415370_ChIP-Seq_HL-1_Mouse1.71492054
27WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.69342566
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.68933084
29EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.61719767
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.61595235
31* EZH2_27294783_Chip-Seq_ESCs_Mouse1.61576071
32KDM2B_26808549_Chip-Seq_K562_Human1.54496357
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52923174
34* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52264176
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.50360854
36WT1_25993318_ChIP-Seq_PODOCYTE_Human1.47719245
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47348729
38DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.45866096
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42525538
40LXR_22292898_ChIP-Seq_THP-1_Human1.41552948
41REST_21632747_ChIP-Seq_MESCs_Mouse1.40711617
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38827129
43TP53_16413492_ChIP-PET_HCT116_Human1.38158134
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37173028
45TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36380413
46SOX9_24532713_ChIP-Seq_HFSC_Mouse1.36120504
47AR_21572438_ChIP-Seq_LNCaP_Human1.34897765
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.31107005
49* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.30650043
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.29821513
51OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.27810947
52AHR_22903824_ChIP-Seq_MCF-7_Human1.26544504
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25483189
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25202944
55CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22279042
56EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22088597
57SMAD4_21799915_ChIP-Seq_A2780_Human1.21334121
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20574174
59BRD4_25478319_ChIP-Seq_HGPS_Human1.20462950
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19585829
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19037385
62AR_19668381_ChIP-Seq_PC3_Human1.18984372
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18831681
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18792264
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17527021
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.17472247
67ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17129040
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.16761941
69REST_18959480_ChIP-ChIP_MESCs_Mouse1.16599786
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16521023
71TP53_20018659_ChIP-ChIP_R1E_Mouse1.16029265
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.15966182
73NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15428637
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15364096
75ESR1_21235772_ChIP-Seq_MCF-7_Human1.15130929
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12894719
77UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12039301
78ESR1_20079471_ChIP-ChIP_T-47D_Human1.11618024
79TBX20_22328084_ChIP-Seq_HEART_Mouse1.10221774
80TBX20_22080862_ChIP-Seq_HEART_Mouse1.10221774
81RING1B_27294783_Chip-Seq_ESCs_Mouse1.08838802
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08233064
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07777858
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07309434
85CJUN_26792858_Chip-Seq_BT549_Human1.05844665
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05196805
87YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05000767
88SMAD3_21741376_ChIP-Seq_HESCs_Human1.04971851
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04895449
90ISL1_27105846_Chip-Seq_CPCs_Mouse1.04417602
91SMAD4_21741376_ChIP-Seq_HESCs_Human1.04395412
92HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04072003
93TP53_22127205_ChIP-Seq_IMR90_Human1.03971334
94KDM2B_26808549_Chip-Seq_DND41_Human1.03337387
95ZNF274_21170338_ChIP-Seq_K562_Hela1.03308585
96STAT3_23295773_ChIP-Seq_U87_Human1.01716846
97KDM2B_26808549_Chip-Seq_JURKAT_Human1.01289805
98RXR_22108803_ChIP-Seq_LS180_Human1.01148916
99* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00533828
100RING1B_27294783_Chip-Seq_NPCs_Mouse1.00392714
101BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99974771
102CLOCK_20551151_ChIP-Seq_293T_Human0.99510423
103SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99485952
104PIAS1_25552417_ChIP-Seq_VCAP_Human0.99232153
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98799581
106GATA2_21666600_ChIP-Seq_HMVEC_Human0.98670209
107DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97841611
108ERG_21242973_ChIP-ChIP_JURKAT_Human0.97497145
109RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97333299
110* TP53_23651856_ChIP-Seq_MEFs_Mouse0.97197448
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97111300
112P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96477376
113CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95607712
114TP53_18474530_ChIP-ChIP_U2OS_Human0.95602533
115TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95592489
116WT1_19549856_ChIP-ChIP_CCG9911_Human0.95340098
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94787594
118NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94465445
119FOXA2_19822575_ChIP-Seq_HepG2_Human0.94393299
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94062612
121NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92645543
122TET1_21490601_ChIP-Seq_MESCs_Mouse0.91539185
123SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.91175544
124ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90886333
125RACK7_27058665_Chip-Seq_MCF-7_Human0.89219643
126* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.88261442
127* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.88261442
128SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.87922768

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.22281062
2MP0005171_absent_coat_pigmentation4.04803496
3MP0000372_irregular_coat_pigmentation3.86594407
4MP0008438_abnormal_cutaneous_collagen3.13048555
5MP0003705_abnormal_hypodermis_morpholog3.11878299
6MP0005623_abnormal_meninges_morphology2.56254837
7MP0003635_abnormal_synaptic_transmissio2.29794723
8MP0000569_abnormal_digit_pigmentation2.27454860
9MP0009780_abnormal_chondrocyte_physiolo2.22604429
10MP0005257_abnormal_intraocular_pressure2.14662038
11MP0002877_abnormal_melanocyte_morpholog2.05587917
12MP0010368_abnormal_lymphatic_system2.03298215
13MP0004270_analgesia2.02392123
14MP0004272_abnormal_basement_membrane2.00149930
15MP0000013_abnormal_adipose_tissue1.98305520
16MP0003279_aneurysm1.92618690
17MP0004858_abnormal_nervous_system1.87442943
18MP0009046_muscle_twitch1.83565474
19MP0004233_abnormal_muscle_weight1.81553126
20MP0004885_abnormal_endolymph1.80657015
21MP0005409_darkened_coat_color1.75806055
22MP0004084_abnormal_cardiac_muscle1.70794397
23MP0005275_abnormal_skin_tensile1.68853469
24MP0002063_abnormal_learning/memory/cond1.66075877
25MP0003045_fibrosis1.63390539
26MP0000751_myopathy1.63094872
27MP0005503_abnormal_tendon_morphology1.60127014
28MP0000371_diluted_coat_color1.56401038
29MP0003283_abnormal_digestive_organ1.56023915
30MP0001958_emphysema1.55777923
31MP0000920_abnormal_myelination1.51048956
32MP0003950_abnormal_plasma_membrane1.50864090
33MP0001299_abnormal_eye_distance/1.48581485
34MP0002064_seizures1.48517821
35MP0001502_abnormal_circadian_rhythm1.47059085
36MP0009745_abnormal_behavioral_response1.39598442
37MP0006138_congestive_heart_failure1.37964816
38MP0003091_abnormal_cell_migration1.35673178
39MP0004215_abnormal_myocardial_fiber1.34460831
40MP0002090_abnormal_vision1.33805199
41MP0006054_spinal_hemorrhage1.31687232
42MP0005408_hypopigmentation1.31650149
43MP0002909_abnormal_adrenal_gland1.30634328
44MP0000733_abnormal_muscle_development1.30625398
45MP0002735_abnormal_chemical_nociception1.30450119
46MP0000767_abnormal_smooth_muscle1.26426593
47MP0000749_muscle_degeneration1.23170093
48MP0002089_abnormal_postnatal_growth/wei1.23031526
49MP0001849_ear_inflammation1.22781237
50MP0008569_lethality_at_weaning1.22354441
51MP0005508_abnormal_skeleton_morphology1.21831730
52MP0000762_abnormal_tongue_morphology1.19217347
53MP0005023_abnormal_wound_healing1.18240020
54MP0001486_abnormal_startle_reflex1.17895735
55MP0003191_abnormal_cellular_cholesterol1.17339975
56MP0002572_abnormal_emotion/affect_behav1.16865101
57MP0000003_abnormal_adipose_tissue1.16577994
58MP0004811_abnormal_neuron_physiology1.15568574
59MP0009384_cardiac_valve_regurgitation1.15536620
60MP0002734_abnormal_mechanical_nocicepti1.14332902
61MP0001915_intracranial_hemorrhage1.14327723
62MP0000428_abnormal_craniofacial_morphol1.14306724
63MP0005167_abnormal_blood-brain_barrier1.13590995
64MP0002108_abnormal_muscle_morphology1.13347258
65MP0003941_abnormal_skin_development1.12526742
66MP0003300_gastrointestinal_ulcer1.11456410
67MP0004510_myositis1.11261245
68MP0004130_abnormal_muscle_cell1.09945670
69MP0003566_abnormal_cell_adhesion1.09577981
70MP0000537_abnormal_urethra_morphology1.09012928
71MP0003633_abnormal_nervous_system1.08617056
72MP0001324_abnormal_eye_pigmentation1.05378885
73MP0004087_abnormal_muscle_fiber1.05251423
74MP0009250_abnormal_appendicular_skeleto1.05008316
75MP0001984_abnormal_olfaction1.04866957
76MP0004145_abnormal_muscle_electrophysio1.04719149
77MP0002060_abnormal_skin_morphology1.03473436
78MP0003115_abnormal_respiratory_system1.02904158
79MP0001879_abnormal_lymphatic_vessel1.02653191
80MP0002837_dystrophic_cardiac_calcinosis1.02337704
81MP0003942_abnormal_urinary_system1.02166111
82MP0000462_abnormal_digestive_system1.01866053
83MP0002249_abnormal_larynx_morphology1.01700671
84MP0003878_abnormal_ear_physiology1.01297757
85MP0005377_hearing/vestibular/ear_phenot1.01297757
86MP0000579_abnormal_nail_morphology1.00051245
87MP0002272_abnormal_nervous_system0.98470341
88MP0003172_abnormal_lysosome_physiology0.98168624
89MP0010030_abnormal_orbit_morphology0.98022399
90MP0004036_abnormal_muscle_relaxation0.97272639
91MP0001348_abnormal_lacrimal_gland0.97091942
92MP0001968_abnormal_touch/_nociception0.96798958
93MP0003329_amyloid_beta_deposits0.96483447
94MP0004484_altered_response_of0.96283134
95MP0002295_abnormal_pulmonary_circulatio0.96129238
96MP0003632_abnormal_nervous_system0.95396336
97MP0003385_abnormal_body_wall0.95341499
98MP0008961_abnormal_basal_metabolism0.95246261
99MP0002557_abnormal_social/conspecific_i0.94964075
100MP0002184_abnormal_innervation0.93428748
101MP0003690_abnormal_glial_cell0.93126270
102MP0002896_abnormal_bone_mineralization0.93074694
103MP0004085_abnormal_heartbeat0.92906198
104MP0000955_abnormal_spinal_cord0.92224819
105MP0000534_abnormal_ureter_morphology0.89507156
106MP0004134_abnormal_chest_morphology0.89501394
107MP0002067_abnormal_sensory_capabilities0.89451367
108MP0000778_abnormal_nervous_system0.88948286
109MP0004924_abnormal_behavior0.88179095
110MP0005386_behavior/neurological_phenoty0.88179095
111MP0005248_abnormal_Harderian_gland0.87679220
112MP0003634_abnormal_glial_cell0.87155695
113MP0001177_atelectasis0.86584852
114MP0002653_abnormal_ependyma_morphology0.85705721
115MP0005165_increased_susceptibility_to0.85275122
116MP0003183_abnormal_peptide_metabolism0.84908709
117MP0005423_abnormal_somatic_nervous0.84273011
118MP0009053_abnormal_anal_canal0.83764103
119MP0005187_abnormal_penis_morphology0.83630927
120MP0000750_abnormal_muscle_regeneration0.83392125
121MP0005670_abnormal_white_adipose0.83195869
122MP0005076_abnormal_cell_differentiation0.82786452
123MP0002733_abnormal_thermal_nociception0.82188754
124MP0000604_amyloidosis0.82005607
125MP0000747_muscle_weakness0.81461496
126MP0002116_abnormal_craniofacial_bone0.81077894
127MP0003631_nervous_system_phenotype0.80372318
128MP0000467_abnormal_esophagus_morphology0.80184675
129MP0005620_abnormal_muscle_contractility0.79354523
130MP0002882_abnormal_neuron_morphology0.78853911
131MP0002972_abnormal_cardiac_muscle0.78398105
132MP0002822_catalepsy0.77713729
133MP0003137_abnormal_impulse_conducting0.76412553
134MP0000759_abnormal_skeletal_muscle0.74939893
135MP0005595_abnormal_vascular_smooth0.74876894
136MP0010630_abnormal_cardiac_muscle0.74664511
137MP0003075_altered_response_to0.74150707
138MP0002075_abnormal_coat/hair_pigmentati0.74006966
139MP0005375_adipose_tissue_phenotype0.73311746

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)3.72774506
2Protrusio acetabuli (HP:0003179)3.71828674
3Premature rupture of membranes (HP:0001788)3.67716916
4Obstructive sleep apnea (HP:0002870)3.55204768
5Shallow orbits (HP:0000586)3.52340505
6Blue irides (HP:0000635)3.44638785
7Neurofibrillary tangles (HP:0002185)3.35452528
8Action tremor (HP:0002345)3.31337714
9Broad metatarsal (HP:0001783)3.08401313
10Broad face (HP:0000283)2.90662736
11Subacute progressive viral hepatitis (HP:0006572)2.87213144
12Aortic aneurysm (HP:0004942)2.82446926
13Bladder diverticulum (HP:0000015)2.79388285
14Spinal rigidity (HP:0003306)2.75912961
15Focal seizures (HP:0007359)2.74184659
16Cervical subluxation (HP:0003308)2.74139545
17Distal upper limb amyotrophy (HP:0007149)2.73545529
18Upper limb amyotrophy (HP:0009129)2.73545529
19Overriding aorta (HP:0002623)2.71369087
20Mitral regurgitation (HP:0001653)2.63491976
21Dysmetric saccades (HP:0000641)2.59731302
22Vascular tortuosity (HP:0004948)2.56170225
23Arterial tortuosity (HP:0005116)2.48458774
24Myokymia (HP:0002411)2.48425801
25Renal duplication (HP:0000075)2.47920644
26Flat cornea (HP:0007720)2.46250816
27Focal motor seizures (HP:0011153)2.44937013
28Ocular albinism (HP:0001107)2.44368616
29Aortic dissection (HP:0002647)2.43843427
30Turricephaly (HP:0000262)2.43039857
31Hypopigmentation of the fundus (HP:0007894)2.42142847
32Hand muscle atrophy (HP:0009130)2.40618328
33Aplasia/Hypoplasia of the macula (HP:0008059)2.40476468
34Aplasia/Hypoplasia affecting the retina (HP:0008061)2.40241712
35Hemiplegia (HP:0002301)2.36224151
36Wormian bones (HP:0002645)2.33452042
37Dilatation of the ascending aorta (HP:0005111)2.32565413
38Mitral valve prolapse (HP:0001634)2.31719609
39Bowel diverticulosis (HP:0005222)2.31332023
40Genetic anticipation (HP:0003743)2.29614640
41Fragile skin (HP:0001030)2.29178017
42Visual hallucinations (HP:0002367)2.26635427
43Aneurysm (HP:0002617)2.23047496
44Macroorchidism (HP:0000053)2.22483590
45Progressive cerebellar ataxia (HP:0002073)2.22143631
46Neonatal short-limb short stature (HP:0008921)2.21754146
47Iris hypopigmentation (HP:0007730)2.15789072
48Overgrowth (HP:0001548)2.15592071
49Supranuclear gaze palsy (HP:0000605)2.13339733
50Abnormality of binocular vision (HP:0011514)2.11867023
51Diplopia (HP:0000651)2.11867023
52Abnormality of skeletal muscle fiber size (HP:0012084)2.09074663
53Type 1 muscle fiber predominance (HP:0003803)2.06888442
54Aplasia involving bones of the extremities (HP:0009825)2.05470105
55Aplasia involving bones of the upper limbs (HP:0009823)2.05470105
56Aplasia of the phalanges of the hand (HP:0009802)2.05470105
57Hyperacusis (HP:0010780)2.03590479
58Scapular winging (HP:0003691)2.03486598
59Postural instability (HP:0002172)2.03424884
60Buphthalmos (HP:0000557)2.03261660
61Hypoplasia of the iris (HP:0007676)2.02682716
62Abnormality of the lower motor neuron (HP:0002366)2.02368354
63Mutism (HP:0002300)2.01461273
64Vertebral compression fractures (HP:0002953)2.00964045
65Distal lower limb amyotrophy (HP:0008944)1.98685182
66Depression (HP:0000716)1.97663089
67Genu recurvatum (HP:0002816)1.97639029
68Short nail (HP:0001799)1.97083478
69Epileptic encephalopathy (HP:0200134)1.95736040
70Truncal ataxia (HP:0002078)1.95704370
71Atrophic scars (HP:0001075)1.95585604
72Annular pancreas (HP:0001734)1.95436553
73Increased connective tissue (HP:0009025)1.94309390
74Ulnar bowing (HP:0003031)1.94029773
75Lymphangioma (HP:0100764)1.93664162
76Dysdiadochokinesis (HP:0002075)1.92434347
77Difficulty running (HP:0009046)1.92124553
78Osteolytic defects of the phalanges of the hand (HP:0009771)1.91571158
79Osteolytic defects of the hand bones (HP:0009699)1.91571158
80Striae distensae (HP:0001065)1.90416119
81Follicular hyperkeratosis (HP:0007502)1.88875082
82Pointed chin (HP:0000307)1.88468866
83Arnold-Chiari malformation (HP:0002308)1.87681466
84Joint laxity (HP:0001388)1.87333859
85Lower limb amyotrophy (HP:0007210)1.87113410
86Atrial fibrillation (HP:0005110)1.86684171
87Asymmetric septal hypertrophy (HP:0001670)1.86553901
88Urinary bladder sphincter dysfunction (HP:0002839)1.86487227
89Primary atrial arrhythmia (HP:0001692)1.86406970
90Bundle branch block (HP:0011710)1.85889413
91Blue sclerae (HP:0000592)1.84051768
92Patellar dislocation (HP:0002999)1.83996835
93Atonic seizures (HP:0010819)1.83873937
94Impaired smooth pursuit (HP:0007772)1.83247736
95Aplasia/Hypoplasia of the fovea (HP:0008060)1.82606718
96Hypoplasia of the fovea (HP:0007750)1.82606718
97Ankle contracture (HP:0006466)1.82288404
98Prolonged QT interval (HP:0001657)1.80810215
99Mildly elevated creatine phosphokinase (HP:0008180)1.80412144
100Insomnia (HP:0100785)1.80355090
101Advanced eruption of teeth (HP:0006288)1.79442083
102Megalocornea (HP:0000485)1.79080426
103Abnormality of the fovea (HP:0000493)1.79013691
104Distal lower limb muscle weakness (HP:0009053)1.78007293
105Peritonitis (HP:0002586)1.77768964
106Urethral obstruction (HP:0000796)1.77424939
107Increased variability in muscle fiber diameter (HP:0003557)1.76948348
108Abnormal ossification of hand bones (HP:0005921)1.75291640
109Supraventricular arrhythmia (HP:0005115)1.75155155
110Elfin facies (HP:0004428)1.74990621
111Biconcave vertebral bodies (HP:0004586)1.74594546
112Gaze-evoked nystagmus (HP:0000640)1.73542403
113Natal tooth (HP:0000695)1.72785767
114Protruding ear (HP:0000411)1.72438903
115Hypoventilation (HP:0002791)1.72278739
116Abnormality of the diencephalon (HP:0010662)1.72127970
117Deviation of the hallux (HP:0010051)1.72061984
118Termporal pattern (HP:0011008)1.72047000
119Insidious onset (HP:0003587)1.72047000
120Limb-girdle muscle weakness (HP:0003325)1.71674667
121Aortic regurgitation (HP:0001659)1.71486079
122Sudden death (HP:0001699)1.71469684
123Intention tremor (HP:0002080)1.70499173
124Long toe (HP:0010511)1.70196603
125Hyperextensible skin (HP:0000974)1.68977573
126Hallux valgus (HP:0001822)1.68938607
127Slender build (HP:0001533)1.68812017
128Impaired social interactions (HP:0000735)1.68801715
129Abnormal social behavior (HP:0012433)1.68801715
130Soft skin (HP:0000977)1.68722283
131Enlarged penis (HP:0000040)1.68601056
132Hyporeflexia of lower limbs (HP:0002600)1.68471493
133Supraventricular tachycardia (HP:0004755)1.68253909
134Bronchomalacia (HP:0002780)1.68204446
135Cerebral inclusion bodies (HP:0100314)1.67008027
136Tibial bowing (HP:0002982)1.66921352
137Precocious puberty (HP:0000826)1.66902492
138Rapidly progressive (HP:0003678)1.66800719
139Hemiparesis (HP:0001269)1.66330894
140Neuronal loss in central nervous system (HP:0002529)1.65939484
141Camptodactyly of toe (HP:0001836)1.65558735
142Bradycardia (HP:0001662)1.65547860
143Ankle clonus (HP:0011448)1.64956413
144Impaired vibration sensation in the lower limbs (HP:0002166)1.64488655
145Abnormality of ocular smooth pursuit (HP:0000617)1.64355742
146Peripheral hypomyelination (HP:0007182)1.64218462
147Poor eye contact (HP:0000817)1.64126955
148Pulmonic stenosis (HP:0001642)1.63661597
149Abnormality of dentin (HP:0010299)1.63306275
150Renovascular hypertension (HP:0100817)1.62108936
151Achilles tendon contracture (HP:0001771)1.61900036
152Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.61601861
153Broad ribs (HP:0000885)1.60992629
154Short 4th metacarpal (HP:0010044)1.60736451
155Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.60736451
156Ankyloglossia (HP:0010296)1.60565655
157Wide anterior fontanel (HP:0000260)1.59479379
158Vertebral arch anomaly (HP:0008438)1.59354979
159Spinal cord compression (HP:0002176)1.56918397
160Abnormality of the distal phalanx of the thumb (HP:0009617)1.56688522
161Mild short stature (HP:0003502)1.55508980
162Venous abnormality (HP:0002624)1.54139251
163Glucose intolerance (HP:0000833)1.53633933

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE13.49945803
2MST1R3.06714436
3TRIB33.00498412
4PKN22.63972379
5RIPK12.44745436
6TESK12.32749886
7MAP3K92.25035100
8PRKD32.22471146
9BMX2.19611053
10NTRK32.18038245
11MARK12.17237623
12CAMKK12.09994860
13CAMK1G2.03047634
14LIMK11.97133372
15PDGFRA1.91780213
16CAMK1D1.89706089
17PAK61.87327016
18DDR21.86607668
19TTN1.68017055
20LATS21.65571752
21NTRK11.59761504
22ERBB41.56525730
23MET1.55750741
24TGFBR21.49727162
25CAMKK21.49202054
26EPHA21.47604123
27EPHA41.44026990
28PHKG11.43984025
29PHKG21.43984025
30SCYL21.43347720
31MINK11.40443581
32NTRK21.39869764
33MAP3K41.38430436
34NEK91.37463130
35MYLK1.35326438
36LMTK21.35120645
37STK381.35049576
38CASK1.34282719
39DMPK1.32067493
40PRKD21.31632641
41LATS11.30668320
42ICK1.28463735
43RET1.25441542
44ROCK21.24733201
45KSR21.22842421
46PTK61.22626370
47CDK121.15193538
48PAK31.12264152
49DAPK21.11532776
50CAMK2B1.08955715
51KDR1.05568065
52ERN11.05180688
53STK38L1.03756312
54PRKCH1.02378667
55FER1.02311291
56CAMK2G1.01017151
57PKN11.00239033
58FGFR40.97302953
59WNK10.94100958
60PTK20.93296551
61EEF2K0.93094721
62PTK2B0.90624296
63CDK50.89927753
64SMG10.89595772
65SGK30.89581174
66TYRO30.88621830
67SIK10.88602704
68KSR10.85422037
69CAMK40.82423202
70SIK20.81926836
71MAP3K20.81885486
72TNK20.81858182
73CAMK2D0.80924065
74MARK30.79047673
75MAP2K40.77499257
76PAK20.76032823
77CDC42BPA0.74461426
78ALK0.73456576
79MARK20.72972020
80TAOK10.71936085
81MAP3K60.71418216
82EPHB10.68981372
83STK110.68596858
84PRKD10.67778294
85PDGFRB0.67337394
86CAMK10.66281952
87SGK2230.65095144
88SGK4940.65095144
89SGK20.64295539
90MTOR0.64034575
91ARAF0.62075387
92TESK20.61550073
93CSNK1A1L0.61388186
94MOS0.60436724
95PRPF4B0.58367082
96MAPK120.58183726
97PDPK10.57434337
98FGFR20.57133959
99NEK60.55766126
100MAPK100.55505844
101PAK40.53422592
102EPHA30.52905386
103FGFR10.52518556
104HIPK20.52338886
105PDK10.52157087
106PLK20.51608051
107CLK10.50980876
108JAK10.50672715
109MAPK70.50479016
110ERBB20.50423775
111EPHB20.50319445
112DYRK1B0.49159991
113ERBB30.48684924
114PRKCE0.47822602
115CDK150.47233561
116GSK3A0.47172419
117PRKCG0.46832765
118UHMK10.46561239
119CDK90.45390367
120SRC0.45161224
121TRPM70.44926922
122NEK10.44530593
123ROCK10.44310087
124SGK10.43936370
125MAP3K70.43818056
126CDK180.43516268
127PRKCZ0.43456242
128PRKAA10.43180349
129CDK11A0.42874184
130ABL20.42674106
131CDK140.42291233
132FYN0.40512935
133RPS6KA20.39755620
134MAP3K10.39493356
135RPS6KA30.39444325
136CAMK2A0.39427337

Predicted pathways (KEGG)

RankGene SetZ-score
1Circadian entrainment_Homo sapiens_hsa047131.86614067
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.72330866
3Synaptic vesicle cycle_Homo sapiens_hsa047211.68413226
4GABAergic synapse_Homo sapiens_hsa047271.68169918
5Long-term potentiation_Homo sapiens_hsa047201.68118635
6Olfactory transduction_Homo sapiens_hsa047401.66600726
7Notch signaling pathway_Homo sapiens_hsa043301.65316475
8Glutamatergic synapse_Homo sapiens_hsa047241.64629082
9Nicotine addiction_Homo sapiens_hsa050331.63608888
10Dilated cardiomyopathy_Homo sapiens_hsa054141.60818443
11Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60299162
12Morphine addiction_Homo sapiens_hsa050321.57197711
13Insulin secretion_Homo sapiens_hsa049111.55325886
14Salivary secretion_Homo sapiens_hsa049701.54053244
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52192043
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51409854
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.50145829
18Gastric acid secretion_Homo sapiens_hsa049711.46466884
19Cholinergic synapse_Homo sapiens_hsa047251.44868122
20Amphetamine addiction_Homo sapiens_hsa050311.38390636
21Estrogen signaling pathway_Homo sapiens_hsa049151.35407990
22Type II diabetes mellitus_Homo sapiens_hsa049301.35240203
23Glioma_Homo sapiens_hsa052141.31185310
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.30168382
25Dopaminergic synapse_Homo sapiens_hsa047281.28713883
26Oxytocin signaling pathway_Homo sapiens_hsa049211.28627619
27Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.28099911
28Melanogenesis_Homo sapiens_hsa049161.27595487
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26256672
30Gap junction_Homo sapiens_hsa045401.25118224
31Nitrogen metabolism_Homo sapiens_hsa009101.24690343
32Renin secretion_Homo sapiens_hsa049241.24597553
33Focal adhesion_Homo sapiens_hsa045101.24536258
34Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.22728258
35GnRH signaling pathway_Homo sapiens_hsa049121.20898461
36Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.20008335
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19680103
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17581937
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16318942
40Cocaine addiction_Homo sapiens_hsa050301.12609729
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12023191
42Axon guidance_Homo sapiens_hsa043601.11674568
43cAMP signaling pathway_Homo sapiens_hsa040241.07628778
44Long-term depression_Homo sapiens_hsa047301.06281712
45mTOR signaling pathway_Homo sapiens_hsa041501.05592203
46Dorso-ventral axis formation_Homo sapiens_hsa043201.04024808
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.03948515
48ECM-receptor interaction_Homo sapiens_hsa045121.02380520
49Proteoglycans in cancer_Homo sapiens_hsa052051.01979527
50Adherens junction_Homo sapiens_hsa045201.01830198
51Renal cell carcinoma_Homo sapiens_hsa052110.99683187
52Rap1 signaling pathway_Homo sapiens_hsa040150.98758197
53Calcium signaling pathway_Homo sapiens_hsa040200.98366424
54Lysine degradation_Homo sapiens_hsa003100.96637572
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.96634221
56Basal cell carcinoma_Homo sapiens_hsa052170.96565406
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95519717
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.94438663
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94108094
60ErbB signaling pathway_Homo sapiens_hsa040120.93269182
61Taste transduction_Homo sapiens_hsa047420.93164924
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93138160
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.91116270
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90691669
65Other glycan degradation_Homo sapiens_hsa005110.87523349
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86582631
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.86154633
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85769755
69Circadian rhythm_Homo sapiens_hsa047100.84906886
70Small cell lung cancer_Homo sapiens_hsa052220.84609875
71Bile secretion_Homo sapiens_hsa049760.83117190
72Vibrio cholerae infection_Homo sapiens_hsa051100.82994496
73Thyroid hormone synthesis_Homo sapiens_hsa049180.82813509
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80787206
75Prostate cancer_Homo sapiens_hsa052150.79389347
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.78927199
77Glucagon signaling pathway_Homo sapiens_hsa049220.78794837
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78765725
79Amoebiasis_Homo sapiens_hsa051460.78422349
80Endocytosis_Homo sapiens_hsa041440.78401747
81Chronic myeloid leukemia_Homo sapiens_hsa052200.78221199
82Endometrial cancer_Homo sapiens_hsa052130.77944297
83PI3K-Akt signaling pathway_Homo sapiens_hsa041510.77345819
84VEGF signaling pathway_Homo sapiens_hsa043700.77007269
85Wnt signaling pathway_Homo sapiens_hsa043100.76277390
86Pathways in cancer_Homo sapiens_hsa052000.74827054
87Insulin signaling pathway_Homo sapiens_hsa049100.74704344
88Bladder cancer_Homo sapiens_hsa052190.74460385
89Protein digestion and absorption_Homo sapiens_hsa049740.72634946
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72404417
91MAPK signaling pathway_Homo sapiens_hsa040100.71735746
92Serotonergic synapse_Homo sapiens_hsa047260.71510640
93Alcoholism_Homo sapiens_hsa050340.71165858
94Inositol phosphate metabolism_Homo sapiens_hsa005620.70981124
95Ras signaling pathway_Homo sapiens_hsa040140.69284782
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.68148532
97Insulin resistance_Homo sapiens_hsa049310.67381014
98Platelet activation_Homo sapiens_hsa046110.66645643
99Prion diseases_Homo sapiens_hsa050200.66147433
100Melanoma_Homo sapiens_hsa052180.65725825
101Choline metabolism in cancer_Homo sapiens_hsa052310.65368102
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.65087692
103Colorectal cancer_Homo sapiens_hsa052100.64870122
104Pancreatic secretion_Homo sapiens_hsa049720.64713121
105Non-small cell lung cancer_Homo sapiens_hsa052230.63135160
106HIF-1 signaling pathway_Homo sapiens_hsa040660.62448342
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58971301
108AMPK signaling pathway_Homo sapiens_hsa041520.58466588
109Tight junction_Homo sapiens_hsa045300.55399081
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54346889
111Oocyte meiosis_Homo sapiens_hsa041140.53878546
112Hippo signaling pathway_Homo sapiens_hsa043900.52796127
113Pancreatic cancer_Homo sapiens_hsa052120.52384424
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.52372034
115Ovarian steroidogenesis_Homo sapiens_hsa049130.51057797
116Lysosome_Homo sapiens_hsa041420.50644352
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50578459
118MicroRNAs in cancer_Homo sapiens_hsa052060.49352513

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »