PCDHGB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. This particular family member is expressed in fibroblasts and is thought to play a role in wound healing in response to injury. Alternative splicing has been described for the gamma cluster genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.85820138
2nucleobase catabolic process (GO:0046113)4.50992698
3presynaptic membrane organization (GO:0097090)3.75148372
4cerebral cortex radially oriented cell migration (GO:0021799)3.68012789
5negative chemotaxis (GO:0050919)3.63100234
6neuron recognition (GO:0008038)3.43312172
7membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.28112836
8retinal ganglion cell axon guidance (GO:0031290)3.24598472
9positive regulation of mitochondrial fission (GO:0090141)3.24470951
10protein heterotrimerization (GO:0070208)3.22348237
11sequestering of extracellular ligand from receptor (GO:0035581)3.13727639
12regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.05752523
13positive regulation of synapse assembly (GO:0051965)3.02670501
14regulation of chemokine-mediated signaling pathway (GO:0070099)3.01399371
15cell migration involved in sprouting angiogenesis (GO:0002042)2.94099906
16regulation of axon extension involved in axon guidance (GO:0048841)2.94078039
17collagen fibril organization (GO:0030199)2.89135431
18vocalization behavior (GO:0071625)2.88457226
19neuron projection extension involved in neuron projection guidance (GO:1902284)2.88080563
20axon extension involved in axon guidance (GO:0048846)2.88080563
21establishment of nucleus localization (GO:0040023)2.83301404
22central nervous system projection neuron axonogenesis (GO:0021952)2.82646876
23nonmotile primary cilium assembly (GO:0035058)2.81523497
24neuron projection extension (GO:1990138)2.80368248
25postsynaptic membrane organization (GO:0001941)2.75169971
26regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.74266049
27G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.72103037
28innervation (GO:0060384)2.71216574
29establishment of mitochondrion localization (GO:0051654)2.69054762
30response to auditory stimulus (GO:0010996)2.68058237
31ganglion development (GO:0061548)2.64249607
32retina layer formation (GO:0010842)2.63869631
33extracellular regulation of signal transduction (GO:1900115)2.63140982
34extracellular negative regulation of signal transduction (GO:1900116)2.63140982
35spinal cord development (GO:0021510)2.61526430
36cAMP catabolic process (GO:0006198)2.60315952
37negative regulation of oligodendrocyte differentiation (GO:0048715)2.59351046
38limb bud formation (GO:0060174)2.57841237
39dendrite morphogenesis (GO:0048813)2.57221769
40pharyngeal system development (GO:0060037)2.57214620
41cyclic nucleotide catabolic process (GO:0009214)2.57070023
42replicative senescence (GO:0090399)2.55814937
43bone trabecula formation (GO:0060346)2.54193995
44synaptic vesicle docking involved in exocytosis (GO:0016081)2.53291793
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.53070821
46* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.53010448
47intraciliary transport (GO:0042073)2.51548632
48synaptic vesicle endocytosis (GO:0048488)2.51291597
49regulation of short-term neuronal synaptic plasticity (GO:0048172)2.50802414
50regulation of respiratory system process (GO:0044065)2.50687660
51neuron cell-cell adhesion (GO:0007158)2.47646679
52presynaptic membrane assembly (GO:0097105)2.47503897
53dendritic spine morphogenesis (GO:0060997)2.47482797
54type B pancreatic cell proliferation (GO:0044342)2.46809591
55axonal fasciculation (GO:0007413)2.45991357
56layer formation in cerebral cortex (GO:0021819)2.45102212
57negative regulation of axon extension (GO:0030517)2.44346602
58lens morphogenesis in camera-type eye (GO:0002089)2.43307125
59startle response (GO:0001964)2.42292235
60gamma-aminobutyric acid transport (GO:0015812)2.41978258
61auditory behavior (GO:0031223)2.41756327
62negative regulation of stem cell proliferation (GO:2000647)2.41036361
63cell migration in hindbrain (GO:0021535)2.40864612
64regulation of glutamate receptor signaling pathway (GO:1900449)2.40863148
65negative regulation of chondrocyte differentiation (GO:0032331)2.40393615
66regulation of non-canonical Wnt signaling pathway (GO:2000050)2.40232453
67dentate gyrus development (GO:0021542)2.40216064
68* calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.39890591
69cAMP-mediated signaling (GO:0019933)2.38899153
70head development (GO:0060322)2.38888438
71negative regulation of osteoblast proliferation (GO:0033689)2.38775470
72mesenchymal-epithelial cell signaling (GO:0060638)2.38311682
73negative regulation of cytosolic calcium ion concentration (GO:0051481)2.37482153
74paraxial mesoderm development (GO:0048339)2.37358986
75atrial cardiac muscle cell action potential (GO:0086014)2.36279361
76negative regulation of synaptic transmission, GABAergic (GO:0032229)2.35898572
77regulation of synapse maturation (GO:0090128)2.35743337
78negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.35025474
79photoreceptor cell differentiation (GO:0046530)2.34210532
80eye photoreceptor cell differentiation (GO:0001754)2.34210532
81central nervous system neuron axonogenesis (GO:0021955)2.34164544
82cell proliferation involved in metanephros development (GO:0072203)2.34099502
83regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.34072989
84retinal cone cell development (GO:0046549)2.33365601
85regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.33030710
86synapse organization (GO:0050808)2.32516691
87growth hormone secretion (GO:0030252)2.32218578
88polarized epithelial cell differentiation (GO:0030859)2.31954389
89limb development (GO:0060173)2.31286689
90appendage development (GO:0048736)2.31286689
91positive regulation of cardiac muscle cell differentiation (GO:2000727)2.30625315
92histone H3-K4 trimethylation (GO:0080182)2.30293063
93regulation of growth hormone secretion (GO:0060123)2.29529601
94regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.29048047
95* cell-cell adhesion via plasma-membrane adhesion molecules (GO:0098742)2.28831338
96glycosphingolipid biosynthetic process (GO:0006688)2.28398476
97* cell-cell adhesion (GO:0098609)2.28208456
98dermatan sulfate biosynthetic process (GO:0030208)2.27949916
99cerebellar Purkinje cell differentiation (GO:0021702)2.27672879
100cranial nerve structural organization (GO:0021604)2.27516376
101mitochondrion distribution (GO:0048311)2.27463887
102olfactory bulb development (GO:0021772)2.27095228
103chondrocyte proliferation (GO:0035988)2.27051633
104neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.25762814
105regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.25455305
106cerebellar granule cell differentiation (GO:0021707)2.25333396
107smooth muscle tissue development (GO:0048745)2.24349425
108negative regulation of axon extension involved in axon guidance (GO:0048843)2.24091671
109lymphangiogenesis (GO:0001946)2.22844053
110negative regulation of translation, ncRNA-mediated (GO:0040033)2.22574872
111regulation of translation, ncRNA-mediated (GO:0045974)2.22574872
112negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.22574872
113negative regulation of axon guidance (GO:1902668)2.22330646
114L-serine transport (GO:0015825)2.22238363
115transmission of nerve impulse (GO:0019226)2.22189612
116planar cell polarity pathway involved in neural tube closure (GO:0090179)2.22087508
117neurotransmitter-gated ion channel clustering (GO:0072578)2.21580962
118urinary tract smooth muscle contraction (GO:0014848)2.21574480
119dendrite development (GO:0016358)2.21470649
120regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.21159285
121retinal rod cell development (GO:0046548)2.20991404
122kidney morphogenesis (GO:0060993)2.20252342
123synaptic transmission, glutamatergic (GO:0035249)2.20006525
124negative regulation of axonogenesis (GO:0050771)2.19428995
125regulation of smoothened signaling pathway (GO:0008589)2.19405659
126short-term memory (GO:0007614)2.19096351
127regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.17740218
128establishment of planar polarity (GO:0001736)2.17477083
129establishment of tissue polarity (GO:0007164)2.17477083
130regulation of synapse assembly (GO:0051963)2.16711352
131mechanosensory behavior (GO:0007638)2.16558527
132hippocampus development (GO:0021766)2.16412654
133G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.16406743
134locomotory exploration behavior (GO:0035641)2.16238173
135lateral sprouting from an epithelium (GO:0060601)2.16216228
136nucleus localization (GO:0051647)2.16134412
137cerebral cortex cell migration (GO:0021795)2.16104548
138axon extension (GO:0048675)2.15969139
139blood vessel maturation (GO:0001955)2.15831320
140somite development (GO:0061053)2.15431578
141inner ear receptor stereocilium organization (GO:0060122)2.15076482
142cell proliferation in forebrain (GO:0021846)2.15020918
143heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.14617015
144developmental cell growth (GO:0048588)2.14591887
145negative regulation of myoblast differentiation (GO:0045662)2.14348302
146convergent extension (GO:0060026)2.13872567
147camera-type eye morphogenesis (GO:0048593)2.13768198
148regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.13362070
149chondroitin sulfate catabolic process (GO:0030207)2.13192928
150positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.12724019
151regulation of timing of cell differentiation (GO:0048505)2.12471705
152craniofacial suture morphogenesis (GO:0097094)2.12147674
153mesenchymal cell differentiation (GO:0048762)2.11731763
154cell adhesion mediated by integrin (GO:0033627)2.11326188
155detection of light stimulus involved in visual perception (GO:0050908)2.11126876
156detection of light stimulus involved in sensory perception (GO:0050962)2.11126876
157ephrin receptor signaling pathway (GO:0048013)2.10802601
158negative regulation of smooth muscle cell migration (GO:0014912)2.10683903
159heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.10555973
160smoothened signaling pathway (GO:0007224)2.09752563
161retina vasculature morphogenesis in camera-type eye (GO:0061299)2.08804558
162synapse assembly (GO:0007416)2.07775725
163protein localization to synapse (GO:0035418)2.07487391
164negative regulation of smoothened signaling pathway (GO:0045879)2.06720387
165negative regulation of keratinocyte proliferation (GO:0010839)2.06108512
166cell communication by electrical coupling (GO:0010644)2.05192442
167pericardium development (GO:0060039)2.04896966
168detection of calcium ion (GO:0005513)2.04368212
169outflow tract septum morphogenesis (GO:0003148)2.04109769
170regulation of axon guidance (GO:1902667)2.04042974

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.14805132
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.12809386
3SMAD_19615063_ChIP-ChIP_OVARY_Human2.82606293
4EZH2_22144423_ChIP-Seq_EOC_Human2.63125059
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.57894228
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.33694197
7WT1_19549856_ChIP-ChIP_CCG9911_Human2.29502841
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14911452
9DROSHA_22980978_ChIP-Seq_HELA_Human2.12792036
10SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.11883000
11ZNF274_21170338_ChIP-Seq_K562_Hela2.06422131
12* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.03196294
13TAF15_26573619_Chip-Seq_HEK293_Human2.02516175
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.00075207
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.98915415
16PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.97833813
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.93866105
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88912916
19JARID2_20064375_ChIP-Seq_MESCs_Mouse1.87567305
20AR_21572438_ChIP-Seq_LNCaP_Human1.85861913
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.85696906
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.82534034
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82331793
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.81644068
25SMAD4_21799915_ChIP-Seq_A2780_Human1.80601963
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79496380
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.78753548
28P300_19829295_ChIP-Seq_ESCs_Human1.76910165
29IGF1R_20145208_ChIP-Seq_DFB_Human1.76230212
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.71791021
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.71791021
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69583933
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.66480669
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.64380043
35* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.63914720
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63281411
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.62909478
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.61630082
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.61481447
40TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.59678876
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59616629
42AHR_22903824_ChIP-Seq_MCF-7_Human1.58823115
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.57581642
44STAT3_23295773_ChIP-Seq_U87_Human1.56788318
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55133593
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.53479472
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.53415044
48FUS_26573619_Chip-Seq_HEK293_Human1.51376168
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.51033495
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.50086283
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49683907
52ARNT_22903824_ChIP-Seq_MCF-7_Human1.49151607
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47815810
54EZH2_27294783_Chip-Seq_ESCs_Mouse1.46577526
55TP53_16413492_ChIP-PET_HCT116_Human1.45585443
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.45429041
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44723156
58TP53_18474530_ChIP-ChIP_U2OS_Human1.44697749
59* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.44645786
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.42892048
61PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.41828194
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.41686464
63ER_23166858_ChIP-Seq_MCF-7_Human1.41497707
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40070394
65* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.39992736
66TCF4_23295773_ChIP-Seq_U87_Human1.39895371
67ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38198098
68E2F1_18555785_Chip-Seq_ESCs_Mouse1.37635724
69TBX3_20139965_ChIP-Seq_ESCs_Mouse1.37153733
70NRF2_20460467_ChIP-Seq_MEFs_Mouse1.37104796
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.37104796
72TBX3_20139965_ChIP-Seq_MESCs_Mouse1.36956748
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35331760
74EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34894433
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34575028
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.34414654
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.33890240
78TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31680788
79AR_25329375_ChIP-Seq_VCAP_Human1.31643863
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31430616
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31379712
82CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31057440
83P53_22387025_ChIP-Seq_ESCs_Mouse1.30078952
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29740643
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29740643
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29598044
87ISL1_27105846_Chip-Seq_CPCs_Mouse1.29324510
88KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.28229201
89SOX2_21211035_ChIP-Seq_LN229_Gbm1.28221391
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27644865
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27383382
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26007142
93EP300_21415370_ChIP-Seq_HL-1_Mouse1.25774967
94CMYC_18555785_Chip-Seq_ESCs_Mouse1.25102139
95SUZ12_18555785_Chip-Seq_ESCs_Mouse1.24775260
96SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24335395
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.23442965
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.23378328
99AR_19668381_ChIP-Seq_PC3_Human1.22740533
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22557113
101RUNX2_22187159_ChIP-Seq_PCA_Human1.21958446
102BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21108115
103* RING1B_27294783_Chip-Seq_ESCs_Mouse1.21084496
104EWS_26573619_Chip-Seq_HEK293_Human1.19679431
105EZH2_27294783_Chip-Seq_NPCs_Mouse1.19124520
106HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18146644
107RNF2_27304074_Chip-Seq_NSC_Mouse1.17695537
108TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.16127410
109YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15789808
110STAT3_18555785_Chip-Seq_ESCs_Mouse1.14725551
111SOX9_26525672_Chip-Seq_HEART_Mouse1.14038237
112CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13730075
113REST_21632747_ChIP-Seq_MESCs_Mouse1.12820128
114HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11467328
115REST_18959480_ChIP-ChIP_MESCs_Mouse1.11207450
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11149295
117TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10343940
118CJUN_26792858_Chip-Seq_BT549_Human1.09564173
119CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09474158
120P300_18555785_Chip-Seq_ESCs_Mouse1.07490536
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07242711
122NMYC_18555785_Chip-Seq_ESCs_Mouse1.07071254
123EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06396550
124UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06087999
125BRD4_25478319_ChIP-Seq_HGPS_Human1.02873418
126MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02461528
127KDM2B_26808549_Chip-Seq_REH_Human1.02323446
128JUN_21703547_ChIP-Seq_K562_Human0.99651939
129LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99240360

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology3.38984282
2MP0000566_synostosis3.34954538
3MP0000569_abnormal_digit_pigmentation2.94934889
4MP0008438_abnormal_cutaneous_collagen2.51564032
5MP0005171_absent_coat_pigmentation2.37677510
6MP0003787_abnormal_imprinting2.32279865
7MP0003122_maternal_imprinting2.29040810
8MP0001188_hyperpigmentation2.18145276
9MP0005645_abnormal_hypothalamus_physiol2.13148250
10MP0004859_abnormal_synaptic_plasticity2.09522336
11MP0006292_abnormal_olfactory_placode2.08991130
12MP0009780_abnormal_chondrocyte_physiolo1.97859380
13MP0000778_abnormal_nervous_system1.96350694
14MP0001502_abnormal_circadian_rhythm1.88427357
15MP0006054_spinal_hemorrhage1.87916331
16MP0002938_white_spotting1.83160271
17MP0005257_abnormal_intraocular_pressure1.67750068
18MP0005646_abnormal_pituitary_gland1.66168777
19MP0002108_abnormal_muscle_morphology1.63973283
20MP0000013_abnormal_adipose_tissue1.62114635
21MP0001486_abnormal_startle_reflex1.57974769
22MP0003121_genomic_imprinting1.56678365
23MP0001299_abnormal_eye_distance/1.54629494
24MP0005551_abnormal_eye_electrophysiolog1.51535916
25MP0010368_abnormal_lymphatic_system1.51001556
26MP0002063_abnormal_learning/memory/cond1.50746722
27MP0005187_abnormal_penis_morphology1.48633276
28MP0003942_abnormal_urinary_system1.47967552
29MP0010030_abnormal_orbit_morphology1.45403133
30MP0003937_abnormal_limbs/digits/tail_de1.41180515
31MP0002638_abnormal_pupillary_reflex1.40832781
32MP0003635_abnormal_synaptic_transmissio1.39926673
33MP0003279_aneurysm1.37610770
34MP0002557_abnormal_social/conspecific_i1.37582527
35MP0004133_heterotaxia1.37032778
36MP0002102_abnormal_ear_morphology1.35781348
37MP0002572_abnormal_emotion/affect_behav1.34581614
38MP0003941_abnormal_skin_development1.33918177
39MP0002163_abnormal_gland_morphology1.31963351
40MP0000751_myopathy1.29812028
41MP0009697_abnormal_copulation1.28794057
42MP0005379_endocrine/exocrine_gland_phen1.26776979
43MP0000516_abnormal_urinary_system1.26511221
44MP0005367_renal/urinary_system_phenotyp1.26511221
45MP0005499_abnormal_olfactory_system1.24789225
46MP0005394_taste/olfaction_phenotype1.24789225
47MP0000955_abnormal_spinal_cord1.24504288
48MP0000631_abnormal_neuroendocrine_gland1.23495110
49MP0004270_analgesia1.23061493
50MP0003183_abnormal_peptide_metabolism1.21922767
51MP0009046_muscle_twitch1.21524983
52MP0009745_abnormal_behavioral_response1.21264362
53MP0002751_abnormal_autonomic_nervous1.20378758
54MP0002822_catalepsy1.17655990
55MP0002876_abnormal_thyroid_physiology1.16057495
56MP0005508_abnormal_skeleton_morphology1.15763108
57MP0001542_abnormal_bone_strength1.14492319
58MP0005248_abnormal_Harderian_gland1.14192366
59MP0008789_abnormal_olfactory_epithelium1.13060730
60MP0001293_anophthalmia1.12902988
61MP0004134_abnormal_chest_morphology1.12031502
62MP0000049_abnormal_middle_ear1.11858427
63MP0001177_atelectasis1.11724711
64MP0002295_abnormal_pulmonary_circulatio1.11415148
65MP0002697_abnormal_eye_size1.11277416
66MP0002734_abnormal_mechanical_nocicepti1.10974183
67MP0009250_abnormal_appendicular_skeleto1.08862812
68MP0001346_abnormal_lacrimal_gland1.08703687
69MP0010386_abnormal_urinary_bladder1.08293634
70MP0002064_seizures1.07691979
71MP0001984_abnormal_olfaction1.06774030
72MP0000537_abnormal_urethra_morphology1.06558867
73MP0003137_abnormal_impulse_conducting1.06297410
74MP0002067_abnormal_sensory_capabilities1.06154946
75MP0004885_abnormal_endolymph1.06093973
76MP0003861_abnormal_nervous_system1.04931993
77MP0000428_abnormal_craniofacial_morphol1.04239325
78MP0003045_fibrosis1.04085044
79MP0003283_abnormal_digestive_organ1.03026035
80MP0002896_abnormal_bone_mineralization1.02338084
81MP0003385_abnormal_body_wall1.01353854
82MP0001968_abnormal_touch/_nociception1.01174882
83MP0002116_abnormal_craniofacial_bone1.01017297
84MP0004858_abnormal_nervous_system1.00197854
85MP0004272_abnormal_basement_membrane1.00144979
86MP0003119_abnormal_digestive_system1.00078080
87MP0004924_abnormal_behavior0.99156639
88MP0005386_behavior/neurological_phenoty0.99156639
89MP0002282_abnormal_trachea_morphology0.99121288
90MP0000015_abnormal_ear_pigmentation0.97993750
91MP0005253_abnormal_eye_physiology0.97136055
92MP0002184_abnormal_innervation0.97046831
93MP0005275_abnormal_skin_tensile0.96863884
94MP0001958_emphysema0.96196135
95MP0000372_irregular_coat_pigmentation0.96132154
96MP0002234_abnormal_pharynx_morphology0.95691054
97MP0002736_abnormal_nociception_after0.95597006
98MP0002752_abnormal_somatic_nervous0.93670793
99MP0004811_abnormal_neuron_physiology0.93358587
100MP0002152_abnormal_brain_morphology0.93256601
101MP0002168_other_aberrant_phenotype0.92951211
102MP0009384_cardiac_valve_regurgitation0.92276950
103MP0003136_yellow_coat_color0.92273362
104MP0002735_abnormal_chemical_nociception0.91659476
105MP0001879_abnormal_lymphatic_vessel0.90725854
106MP0002882_abnormal_neuron_morphology0.88073381
107MP0003755_abnormal_palate_morphology0.88043020
108MP0001270_distended_abdomen0.87521152
109MP0005409_darkened_coat_color0.87383255
110MP0000767_abnormal_smooth_muscle0.87330169
111MP0000462_abnormal_digestive_system0.87126094
112MP0003935_abnormal_craniofacial_develop0.86535706
113MP0002233_abnormal_nose_morphology0.86485458
114MP0004142_abnormal_muscle_tone0.86358754
115MP0002092_abnormal_eye_morphology0.86294273
116MP0003115_abnormal_respiratory_system0.86274677
117MP0003880_abnormal_central_pattern0.86000761
118MP0004215_abnormal_myocardial_fiber0.85891160
119MP0001501_abnormal_sleep_pattern0.85474905
120MP0006072_abnormal_retinal_apoptosis0.84274457
121MP0004484_altered_response_of0.84113379
122MP0008569_lethality_at_weaning0.83561092
123MP0002177_abnormal_outer_ear0.82477430
124MP0005197_abnormal_uvea_morphology0.82407420
125MP0003950_abnormal_plasma_membrane0.82241485
126MP0003938_abnormal_ear_development0.82154885
127MP0005623_abnormal_meninges_morphology0.81875579
128MP0005391_vision/eye_phenotype0.81336861
129MP0000026_abnormal_inner_ear0.81002959
130MP0001286_abnormal_eye_development0.80749317
131MP0001529_abnormal_vocalization0.79475432
132MP0004085_abnormal_heartbeat0.78703911
133MP0006276_abnormal_autonomic_nervous0.77959913
134MP0005423_abnormal_somatic_nervous0.77810966
135MP0000534_abnormal_ureter_morphology0.77724251
136MP0000681_abnormal_thyroid_gland0.76791648
137MP0002272_abnormal_nervous_system0.75362746
138MP0002249_abnormal_larynx_morphology0.75032283
139MP0004233_abnormal_muscle_weight0.73824549
140MP0002653_abnormal_ependyma_morphology0.73722809

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.13183265
2Protrusio acetabuli (HP:0003179)3.67400363
3Abnormality of dentin (HP:0010299)3.25826949
4Abnormal hair whorl (HP:0010721)2.89236412
5Chronic hepatic failure (HP:0100626)2.87080920
6Soft skin (HP:0000977)2.74950600
7Follicular hyperkeratosis (HP:0007502)2.74245023
8Febrile seizures (HP:0002373)2.72063355
9Aortic dissection (HP:0002647)2.68443803
10Broad metatarsal (HP:0001783)2.60559214
11Vitreoretinal degeneration (HP:0000655)2.60330564
12Abnormality of the nasal septum (HP:0000419)2.59149217
13Bladder diverticulum (HP:0000015)2.56037532
14Wrist flexion contracture (HP:0001239)2.41354762
15Epileptic encephalopathy (HP:0200134)2.40902381
16Hypoventilation (HP:0002791)2.40514942
17True hermaphroditism (HP:0010459)2.39843882
18Shallow orbits (HP:0000586)2.38077417
19Abnormality of the right ventricle (HP:0001707)2.37846566
20Cortical dysplasia (HP:0002539)2.37104565
21Abnormality of the lower motor neuron (HP:0002366)2.36539349
22Protruding tongue (HP:0010808)2.35560166
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.29704598
24Gait imbalance (HP:0002141)2.28865846
25Wide anterior fontanel (HP:0000260)2.25173613
26Ankle contracture (HP:0006466)2.24306754
27Coronal craniosynostosis (HP:0004440)2.22378749
28Short 4th metacarpal (HP:0010044)2.21944161
29Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.21944161
30Genetic anticipation (HP:0003743)2.19457389
31Focal motor seizures (HP:0011153)2.18623321
32Tubulointerstitial nephritis (HP:0001970)2.18597413
33Urethral obstruction (HP:0000796)2.17649324
34Atrophic scars (HP:0001075)2.14386152
35Narrow palate (HP:0000189)2.13290672
36Aortic aneurysm (HP:0004942)2.12710477
37Genu recurvatum (HP:0002816)2.12384999
38Bifid tongue (HP:0010297)2.10495375
39Nephrogenic diabetes insipidus (HP:0009806)2.10059477
40Trigonocephaly (HP:0000243)2.09865889
41Medial flaring of the eyebrow (HP:0010747)2.08029671
42Midline defect of the nose (HP:0004122)2.07140098
43Genital tract atresia (HP:0001827)2.06419094
44Bowel diverticulosis (HP:0005222)2.06221554
45Congenital primary aphakia (HP:0007707)2.05497306
46Vaginal atresia (HP:0000148)2.05388068
47Abnormality of the fingertips (HP:0001211)2.05132299
48Septo-optic dysplasia (HP:0100842)2.02454574
49Abnormality of incisor morphology (HP:0011063)2.02205504
50Papillary thyroid carcinoma (HP:0002895)2.00669575
51Hand muscle atrophy (HP:0009130)2.00616697
52Pancreatic fibrosis (HP:0100732)2.00212564
53Broad ribs (HP:0000885)1.97973381
54Morphological abnormality of the middle ear (HP:0008609)1.95975479
55Aplasia/Hypoplasia of the lens (HP:0008063)1.95422918
56Abnormality of the nasolacrimal system (HP:0000614)1.95317671
57Abnormality of the parietal bone (HP:0002696)1.93980251
58Limb-girdle muscle weakness (HP:0003325)1.93517124
59Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.91333551
60Lissencephaly (HP:0001339)1.90615301
61Overgrowth (HP:0001548)1.90239378
62Cutaneous finger syndactyly (HP:0010554)1.90019553
63Hypoplasia of the fovea (HP:0007750)1.89852086
64Aplasia/Hypoplasia of the fovea (HP:0008060)1.89852086
65Abnormality of the labia minora (HP:0012880)1.88468254
66Neoplasm of the adrenal cortex (HP:0100641)1.88360327
67Abnormality of the fovea (HP:0000493)1.87953560
68Hypoplasia of the maxilla (HP:0000327)1.86850261
69Poor coordination (HP:0002370)1.86685922
70Bradycardia (HP:0001662)1.86231449
71Volvulus (HP:0002580)1.86185839
72Congenital stationary night blindness (HP:0007642)1.85534540
73Abnormality of the lacrimal duct (HP:0011481)1.84880064
74Atrial fibrillation (HP:0005110)1.84554309
75Postaxial foot polydactyly (HP:0001830)1.84042345
76Amyotrophic lateral sclerosis (HP:0007354)1.83806639
77Ectopic kidney (HP:0000086)1.83012624
78Absent eyebrow (HP:0002223)1.81912374
79Hyperglycinemia (HP:0002154)1.81736014
80Hepatoblastoma (HP:0002884)1.81221555
81Hyperventilation (HP:0002883)1.80916124
82Spinal rigidity (HP:0003306)1.80102861
83Prolonged QT interval (HP:0001657)1.79994114
84Hypoplasia of the brainstem (HP:0002365)1.79684433
85Aplasia/Hypoplasia of the brainstem (HP:0007362)1.79684433
86Mitral stenosis (HP:0001718)1.79683747
87Broad foot (HP:0001769)1.78880101
88Long eyelashes (HP:0000527)1.78517375
89Renal hypoplasia (HP:0000089)1.77900658
90Abnormality of molar (HP:0011077)1.77814424
91Abnormality of molar morphology (HP:0011070)1.77814424
92Drooling (HP:0002307)1.77495618
93Excessive salivation (HP:0003781)1.77495618
94Osteomalacia (HP:0002749)1.75902414
95Abnormality of the musculature of the pelvis (HP:0001469)1.75582810
96Abnormality of the hip-girdle musculature (HP:0001445)1.75582810
97Severe Myopia (HP:0011003)1.74658590
98Chromsome breakage (HP:0040012)1.74296761
99Long nose (HP:0003189)1.74230498
100Aqueductal stenosis (HP:0002410)1.73645343
101Flat cornea (HP:0007720)1.73568722
102Hemiparesis (HP:0001269)1.73552990
103Vascular tortuosity (HP:0004948)1.72032873
104Nasolacrimal duct obstruction (HP:0000579)1.71687549
105Bell-shaped thorax (HP:0001591)1.71674285
106Hip dysplasia (HP:0001385)1.71535877
107Elfin facies (HP:0004428)1.71432509
108Primary atrial arrhythmia (HP:0001692)1.71318300
109Mesomelia (HP:0003027)1.71021280
110Arterial tortuosity (HP:0005116)1.70497657
111Short tibia (HP:0005736)1.69456920
112Accelerated skeletal maturation (HP:0005616)1.69421453
113Broad long bones (HP:0005622)1.69319152
114Narrow nasal bridge (HP:0000446)1.69183621
115Abnormality of the dental pulp (HP:0006479)1.67411342
116Infantile muscular hypotonia (HP:0008947)1.67004229
117Action tremor (HP:0002345)1.66819752
118Abnormality of permanent molar morphology (HP:0011071)1.66676870
119Abnormality of the dental root (HP:0006486)1.66676870
120Taurodontia (HP:0000679)1.66676870
121Neonatal short-limb short stature (HP:0008921)1.66135881
122Wormian bones (HP:0002645)1.66107309
123Hammertoe (HP:0001765)1.65953649
124Delayed gross motor development (HP:0002194)1.65701423
125Short foot (HP:0001773)1.65528574
126Cervical subluxation (HP:0003308)1.64773832
127Cutaneous syndactyly (HP:0012725)1.64578461
128Aplasia/Hypoplasia of the tongue (HP:0010295)1.63275851
129Retinal dysplasia (HP:0007973)1.62360156
130Obsessive-compulsive behavior (HP:0000722)1.61918239
131Specific learning disability (HP:0001328)1.61752362
132Polyphagia (HP:0002591)1.61657190
133Alacrima (HP:0000522)1.61469937
134Absent speech (HP:0001344)1.61269217
135Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.61133075
136Blue irides (HP:0000635)1.60944405
137Micropenis (HP:0000054)1.60843523
138Occipital encephalocele (HP:0002085)1.60454827
139Pachygyria (HP:0001302)1.60406384
140Increased corneal curvature (HP:0100692)1.60156366
141Keratoconus (HP:0000563)1.60156366
142Decreased circulating renin level (HP:0003351)1.60103702
143Progressive cerebellar ataxia (HP:0002073)1.59783252
144Renal duplication (HP:0000075)1.59473349
145Broad-based gait (HP:0002136)1.59196930
146Exotropia (HP:0000577)1.58916501
147Truncal obesity (HP:0001956)1.58609965
148Mitral valve prolapse (HP:0001634)1.58554851
149Widely spaced teeth (HP:0000687)1.58148161
150Aplasia involving bones of the extremities (HP:0009825)1.58135492
151Aplasia involving bones of the upper limbs (HP:0009823)1.58135492
152Aplasia of the phalanges of the hand (HP:0009802)1.58135492
153Optic nerve hypoplasia (HP:0000609)1.57879098
154Pulmonic stenosis (HP:0001642)1.57857298
155Macroorchidism (HP:0000053)1.56926578
156Abnormality of the incisor (HP:0000676)1.56647499
157Anophthalmia (HP:0000528)1.56497804
158Abnormality of the 4th metacarpal (HP:0010012)1.56260951
159Intestinal atresia (HP:0011100)1.56062776
160Postaxial hand polydactyly (HP:0001162)1.55666832
161Abnormality of the ischium (HP:0003174)1.55647843
162Decreased lacrimation (HP:0000633)1.55561949
163Abnormal EKG (HP:0003115)1.54943326
164Scrotal hypoplasia (HP:0000046)1.54760191
165Exercise-induced muscle cramps (HP:0003710)1.54467100
166Lymphangioma (HP:0100764)1.52753386
167Broad palm (HP:0001169)1.52050367
168Dental crowding (HP:0000678)1.51813734
169Narrow forehead (HP:0000341)1.51557358
170Aplasia/Hypoplasia of the tibia (HP:0005772)1.50962068
171Distal upper limb amyotrophy (HP:0007149)1.50680233

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR3.79608572
2CASK3.16309253
3PRPF4B2.91725706
4MARK12.89249823
5TNIK2.80029503
6MAP4K22.58765076
7TRIM282.57872642
8SIK32.44324268
9ZAK2.41862792
10TAOK22.40399453
11ERBB32.38807623
12NTRK32.15606614
13SGK21.99595997
14DDR21.96923834
15CAMK1D1.93694987
16MAPK131.90985999
17NTRK11.84277058
18DYRK1B1.79856108
19BMPR1B1.78031816
20BRD41.75478365
21AKT31.67553049
22MAP2K71.63881349
23TIE11.57129152
24CSNK1G21.56387940
25STK38L1.55232303
26CDK191.54449952
27NTRK21.52947759
28CSNK1G31.50850958
29PIM21.50841416
30NEK61.45757392
31LIMK11.44006149
32NUAK11.39602400
33CSNK1G11.39502992
34BMPR21.37575741
35SGK31.37222971
36CAMK1G1.36156070
37SGK2231.31280005
38SGK4941.31280005
39BCR1.29346587
40EIF2AK21.26262166
41CDK31.21636101
42FLT31.18823464
43NEK91.18362673
44SRPK11.16428194
45EPHA41.15456712
46FGFR21.14668143
47EPHA31.14437693
48PAK61.13758581
49WNK31.07729832
50PRKCE1.07710899
51PRKD31.07457025
52GRK71.07193748
53MYLK1.05859567
54DYRK31.05814751
55PLK21.05791461
56TESK11.05786782
57LATS11.02075072
58PKN21.01357145
59IRAK30.98156728
60DMPK0.98083086
61FRK0.98004300
62CDC42BPA0.97944902
63STK380.97345545
64MAP3K60.95549385
65MAP2K40.94069443
66PRKD20.93730457
67FER0.92223390
68ADRBK20.91962360
69PRKCH0.91104759
70CAMK40.90352646
71DYRK20.88013956
72ICK0.87143489
73WNK10.86563162
74PAK20.86193170
75PKN10.86033157
76PHKG10.85653194
77PHKG20.85653194
78RPS6KA40.85144545
79KSR10.84571892
80PTK20.83251576
81OBSCN0.81975239
82TXK0.81472234
83FGFR30.80159822
84MAP3K40.79757656
85IRAK10.79007288
86GRK10.78039994
87ROCK20.76432906
88MET0.74636017
89PDGFRA0.73813979
90EPHB20.73016116
91RPS6KB10.69312741
92SGK10.66862159
93YES10.66463496
94CDK140.64077003
95TRPM70.63655956
96TGFBR20.62717257
97PRKAA10.59340947
98FGFR10.59230352
99CDK80.58637053
100MAP2K60.55504375
101MAP3K50.54122281
102CDK180.53879630
103PIK3CA0.53423446
104IRAK40.53287136
105MINK10.53083269
106CAMK2A0.52997153
107TEC0.52587810
108MAPK70.52185169
109DYRK1A0.51124774
110PAK30.50819758
111MAPK150.50450107
112PRKCG0.50421123
113CAMKK20.50231191
114PLK30.49965742
115LMTK20.49655639
116ADRBK10.49648398
117ERBB20.48786600
118ROCK10.48102577
119CDK120.47770380
120LATS20.46830662
121CCNB10.45721443
122ATR0.45556982
123CDK150.44625994
124CDK11A0.44558193
125ERBB40.44033944
126CSNK1D0.43988382
127CLK10.43424116
128JAK10.43277424
129SIK10.42931084
130CAMK2B0.42853852
131PDGFRB0.42302505
132MKNK10.42027533
133CAMK10.41536716
134PRKG10.41533282
135MAPK80.40292993
136CSNK1A1L0.38456984
137RIPK10.38352522
138DAPK30.38346627
139GSK3B0.38324307
140CHUK0.37726119
141RPS6KA20.37483802
142PINK10.37482534
143CDK50.37094148
144ACVR1B0.37004330
145PRKCZ0.36407787
146CAMK2G0.35302052
147UHMK10.35280266
148BCKDK0.35209781
149TYRO30.33687900
150CSNK1A10.33150410
151WNK40.33117284
152MARK20.32366343

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.39446141
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.33197304
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.18625018
4Steroid biosynthesis_Homo sapiens_hsa001002.14781897
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.14193481
6Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.06601237
7Morphine addiction_Homo sapiens_hsa050321.99483007
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.94671363
9Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.89097267
10Circadian entrainment_Homo sapiens_hsa047131.86679209
11Insulin secretion_Homo sapiens_hsa049111.81475190
12Dilated cardiomyopathy_Homo sapiens_hsa054141.76723866
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.73472077
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.62500652
15Olfactory transduction_Homo sapiens_hsa047401.59057980
16GABAergic synapse_Homo sapiens_hsa047271.58018784
17Phototransduction_Homo sapiens_hsa047441.57296779
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.55266692
19Taste transduction_Homo sapiens_hsa047421.53571861
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.50343515
21Circadian rhythm_Homo sapiens_hsa047101.49897709
22Glutamatergic synapse_Homo sapiens_hsa047241.47975562
23Axon guidance_Homo sapiens_hsa043601.47236533
24Protein digestion and absorption_Homo sapiens_hsa049741.43135328
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39855973
26Basal cell carcinoma_Homo sapiens_hsa052171.31957203
27Butanoate metabolism_Homo sapiens_hsa006501.30231790
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29024536
29Protein export_Homo sapiens_hsa030601.28969169
30cAMP signaling pathway_Homo sapiens_hsa040241.28611009
31Amphetamine addiction_Homo sapiens_hsa050311.27705405
32Calcium signaling pathway_Homo sapiens_hsa040201.26897814
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.26809163
34Serotonergic synapse_Homo sapiens_hsa047261.23246405
35Renin secretion_Homo sapiens_hsa049241.21905778
36Cholinergic synapse_Homo sapiens_hsa047251.20647342
37Type II diabetes mellitus_Homo sapiens_hsa049301.20330964
38Cocaine addiction_Homo sapiens_hsa050301.18418046
39Synaptic vesicle cycle_Homo sapiens_hsa047211.17126457
40Wnt signaling pathway_Homo sapiens_hsa043101.16841159
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13713224
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.11701727
43Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10060766
44Tight junction_Homo sapiens_hsa045301.09369683
45Adherens junction_Homo sapiens_hsa045201.05719696
46Propanoate metabolism_Homo sapiens_hsa006401.04854087
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04194762
48Ovarian steroidogenesis_Homo sapiens_hsa049131.02531796
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.00657076
50Dopaminergic synapse_Homo sapiens_hsa047281.00005827
51Hedgehog signaling pathway_Homo sapiens_hsa043400.99890351
52Salivary secretion_Homo sapiens_hsa049700.99432300
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97169155
54Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96924915
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93749632
56Melanogenesis_Homo sapiens_hsa049160.92382735
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.92326144
58ECM-receptor interaction_Homo sapiens_hsa045120.91358446
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91265525
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89794715
61Melanoma_Homo sapiens_hsa052180.89621773
62Notch signaling pathway_Homo sapiens_hsa043300.88658679
63Oxytocin signaling pathway_Homo sapiens_hsa049210.87497896
64Hippo signaling pathway_Homo sapiens_hsa043900.86210497
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.84719324
66Long-term potentiation_Homo sapiens_hsa047200.84618334
67ErbB signaling pathway_Homo sapiens_hsa040120.84173322
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.82656710
69Inositol phosphate metabolism_Homo sapiens_hsa005620.82297029
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.82030383
71AMPK signaling pathway_Homo sapiens_hsa041520.80433521
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80098526
73Rap1 signaling pathway_Homo sapiens_hsa040150.78996687
74Endometrial cancer_Homo sapiens_hsa052130.78703015
75MAPK signaling pathway_Homo sapiens_hsa040100.76669401
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76342774
77Fanconi anemia pathway_Homo sapiens_hsa034600.76292485
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76156581
79Rheumatoid arthritis_Homo sapiens_hsa053230.76008055
80GnRH signaling pathway_Homo sapiens_hsa049120.74313664
81Malaria_Homo sapiens_hsa051440.73366112
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72979532
83Gastric acid secretion_Homo sapiens_hsa049710.72579702
84Pathways in cancer_Homo sapiens_hsa052000.70677625
85Ras signaling pathway_Homo sapiens_hsa040140.70358096
86Lysine degradation_Homo sapiens_hsa003100.70062971
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69822792
88Fatty acid metabolism_Homo sapiens_hsa012120.69565193
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68585585
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67732042
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67181039
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66782365
93MicroRNAs in cancer_Homo sapiens_hsa052060.66263228
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66191785
95Focal adhesion_Homo sapiens_hsa045100.65718442
96Prostate cancer_Homo sapiens_hsa052150.65605201
97N-Glycan biosynthesis_Homo sapiens_hsa005100.65498544
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.64984882
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64984646
100Proteoglycans in cancer_Homo sapiens_hsa052050.63995825
101Colorectal cancer_Homo sapiens_hsa052100.63731894
102Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63541409
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63223721
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.62951987
105Fatty acid elongation_Homo sapiens_hsa000620.62850186
106NF-kappa B signaling pathway_Homo sapiens_hsa040640.62753555
107TNF signaling pathway_Homo sapiens_hsa046680.62676515
108African trypanosomiasis_Homo sapiens_hsa051430.61187534
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60752580
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60595160
111Glioma_Homo sapiens_hsa052140.60157691
112FoxO signaling pathway_Homo sapiens_hsa040680.60035647
113TGF-beta signaling pathway_Homo sapiens_hsa043500.59447779
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59244560
115Type I diabetes mellitus_Homo sapiens_hsa049400.58111030
116Vibrio cholerae infection_Homo sapiens_hsa051100.57018264
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56982360
118Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55883946
119Gap junction_Homo sapiens_hsa045400.55167154
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55051210
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54048532
122Long-term depression_Homo sapiens_hsa047300.53206212
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52602807
124Estrogen signaling pathway_Homo sapiens_hsa049150.51793777
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51756031
126Thyroid hormone synthesis_Homo sapiens_hsa049180.50531517
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.50016617
128Basal transcription factors_Homo sapiens_hsa030220.48355962
129Viral myocarditis_Homo sapiens_hsa054160.48199047
130Choline metabolism in cancer_Homo sapiens_hsa052310.47840345
131Biosynthesis of amino acids_Homo sapiens_hsa012300.46061711
132Regulation of autophagy_Homo sapiens_hsa041400.44309285
133Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43305003
134Peroxisome_Homo sapiens_hsa041460.41662377
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40745021
136Alcoholism_Homo sapiens_hsa050340.39957230
137Amoebiasis_Homo sapiens_hsa051460.36224121
138Carbon metabolism_Homo sapiens_hsa012000.34659287
139Cardiac muscle contraction_Homo sapiens_hsa042600.32539733

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