PCDHGB6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)7.88451983
2nucleobase catabolic process (GO:0046113)6.13554111
3locomotory exploration behavior (GO:0035641)5.00067592
4presynaptic membrane assembly (GO:0097105)4.89983208
5establishment of mitochondrion localization (GO:0051654)4.82396557
6sodium ion export (GO:0071436)4.71813463
7presynaptic membrane organization (GO:0097090)4.65712602
8synaptic vesicle maturation (GO:0016188)4.63943060
9regulation of short-term neuronal synaptic plasticity (GO:0048172)4.56501560
10layer formation in cerebral cortex (GO:0021819)4.54216610
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.44212519
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.29450002
13cellular potassium ion homeostasis (GO:0030007)4.21570522
14regulation of synapse structural plasticity (GO:0051823)4.14433294
15vocalization behavior (GO:0071625)3.99535064
16cell communication by electrical coupling (GO:0010644)3.92597777
17synaptic vesicle exocytosis (GO:0016079)3.92288684
18synaptic vesicle docking involved in exocytosis (GO:0016081)3.87691786
19cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.87079669
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.86817864
21dendritic spine morphogenesis (GO:0060997)3.81898454
22calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.79606478
23regulation of synaptic vesicle exocytosis (GO:2000300)3.74511607
24establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.72982161
25mitochondrion transport along microtubule (GO:0047497)3.72982161
26dendrite morphogenesis (GO:0048813)3.72219962
27spinal cord development (GO:0021510)3.69078719
28retinal ganglion cell axon guidance (GO:0031290)3.66714665
29regulation of axon guidance (GO:1902667)3.56969333
30exploration behavior (GO:0035640)3.56956750
31regulation of glutamate receptor signaling pathway (GO:1900449)3.55774024
32positive regulation of synapse maturation (GO:0090129)3.53370815
33axon extension (GO:0048675)3.52198120
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.51166089
35regulation of axon extension involved in axon guidance (GO:0048841)3.45470679
36regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.41127292
37negative regulation of cytosolic calcium ion concentration (GO:0051481)3.40748908
38glial cell proliferation (GO:0014009)3.39624208
39glutamate secretion (GO:0014047)3.39030982
40startle response (GO:0001964)3.38748468
41negative regulation of axon guidance (GO:1902668)3.38650471
42positive regulation of synapse assembly (GO:0051965)3.37357764
43axon extension involved in axon guidance (GO:0048846)3.35006089
44neuron projection extension involved in neuron projection guidance (GO:1902284)3.35006089
45positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.33366844
46prepulse inhibition (GO:0060134)3.32386124
47protein localization to synapse (GO:0035418)3.31321517
48limb bud formation (GO:0060174)3.29864207
49behavioral response to nicotine (GO:0035095)3.28131420
50establishment of nucleus localization (GO:0040023)3.26629847
51ionotropic glutamate receptor signaling pathway (GO:0035235)3.25514575
52innervation (GO:0060384)3.25175283
53cellular sodium ion homeostasis (GO:0006883)3.25110062
54neurotransmitter secretion (GO:0007269)3.24270108
55axonal fasciculation (GO:0007413)3.22356139
56neurotransmitter-gated ion channel clustering (GO:0072578)3.22050425
57activation of protein kinase A activity (GO:0034199)3.16829843
58regulation of neuronal synaptic plasticity (GO:0048168)3.16721438
59negative regulation of axon extension involved in axon guidance (GO:0048843)3.15415190
60lateral sprouting from an epithelium (GO:0060601)3.14473735
61glutamate receptor signaling pathway (GO:0007215)3.13183874
62proline transport (GO:0015824)3.12355126
63cerebellar granule cell differentiation (GO:0021707)3.11416863
64regulation of synaptic vesicle transport (GO:1902803)3.10262769
65cell migration in hindbrain (GO:0021535)3.10052107
66positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.09423735
67synaptic transmission, glutamatergic (GO:0035249)3.09267183
68potassium ion homeostasis (GO:0055075)3.08928269
69response to pheromone (GO:0019236)3.06996740
70G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.06804220
71neuromuscular process controlling balance (GO:0050885)3.06456977
72gamma-aminobutyric acid transport (GO:0015812)3.06299792
73regulation of long-term neuronal synaptic plasticity (GO:0048169)3.05364238
74potassium ion import (GO:0010107)3.03903576
75positive regulation of synaptic transmission, GABAergic (GO:0032230)3.03181064
76central nervous system neuron axonogenesis (GO:0021955)3.02828086
77cerebral cortex radially oriented cell migration (GO:0021799)3.02800415
78dendrite development (GO:0016358)2.97680675
79suckling behavior (GO:0001967)2.97036220
80cerebellar Purkinje cell differentiation (GO:0021702)2.95980633
81neuronal stem cell maintenance (GO:0097150)2.94239121
82neuron migration (GO:0001764)2.93207087
83nonmotile primary cilium assembly (GO:0035058)2.93190659
84negative chemotaxis (GO:0050919)2.91876855
85neuron recognition (GO:0008038)2.89718990
86epithelial cell differentiation involved in kidney development (GO:0035850)2.89525518
87response to auditory stimulus (GO:0010996)2.88719390
88synapse assembly (GO:0007416)2.88617918
89regulation of synaptic transmission, glutamatergic (GO:0051966)2.88561201
90auditory behavior (GO:0031223)2.87906529
91hippocampus development (GO:0021766)2.87825724
92regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.87231136
93neuron projection extension (GO:1990138)2.86593344
94synaptic vesicle endocytosis (GO:0048488)2.85870172
95long-term memory (GO:0007616)2.84200506
96regulation of dendritic spine morphogenesis (GO:0061001)2.83431027
97mechanosensory behavior (GO:0007638)2.83243183
98neuron cell-cell adhesion (GO:0007158)2.83204521
99membrane depolarization during action potential (GO:0086010)2.82826118
100negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.81525051
101neuron-neuron synaptic transmission (GO:0007270)2.79528803
102central nervous system projection neuron axonogenesis (GO:0021952)2.78803405
103cell communication involved in cardiac conduction (GO:0086065)2.77487879
104neuronal ion channel clustering (GO:0045161)2.77362468
105camera-type eye morphogenesis (GO:0048593)2.77325676
106axon cargo transport (GO:0008088)2.76146479
107apical protein localization (GO:0045176)2.74147218
108heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.72038442
109membrane hyperpolarization (GO:0060081)2.71096313
110mating behavior (GO:0007617)2.71027825
111forebrain neuron differentiation (GO:0021879)2.70913398
112adult walking behavior (GO:0007628)2.69467415
113regulation of excitatory postsynaptic membrane potential (GO:0060079)2.69106785
114organelle transport along microtubule (GO:0072384)2.69089194
115neuromuscular synaptic transmission (GO:0007274)2.67892230
116Notch signaling involved in heart development (GO:0061314)2.66111304
117membrane repolarization (GO:0086009)2.65406637
118olfactory bulb development (GO:0021772)2.65306747
119regulation of synapse assembly (GO:0051963)2.65091192
120synapse organization (GO:0050808)2.64725519
121axonogenesis (GO:0007409)2.64582862
122protein heterotrimerization (GO:0070208)2.63590863
123regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.62377308
124cerebellar Purkinje cell layer development (GO:0021680)2.62208358
125regulation of postsynaptic membrane potential (GO:0060078)2.62173362
126negative regulation of axon extension (GO:0030517)2.61544656
127cytoskeletal anchoring at plasma membrane (GO:0007016)2.60960374
128positive regulation of mitochondrial fission (GO:0090141)2.60653080
129positive regulation of potassium ion transmembrane transport (GO:1901381)2.60524976
130adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.60426891
131regulation of ARF protein signal transduction (GO:0032012)2.60089685
132transmission of nerve impulse (GO:0019226)2.59999363
133negative regulation of oligodendrocyte differentiation (GO:0048715)2.59983857
134positive regulation of membrane potential (GO:0045838)2.59915727
135alanine transport (GO:0032328)2.59804555
136dendritic spine organization (GO:0097061)2.58466816
137regulation of respiratory system process (GO:0044065)2.55268646
138positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.54082595
139long-term synaptic potentiation (GO:0060291)2.54060470
140dopamine receptor signaling pathway (GO:0007212)2.51907796
141appendage development (GO:0048736)2.51535639
142limb development (GO:0060173)2.51535639
143striatum development (GO:0021756)2.51045101
144neurofilament cytoskeleton organization (GO:0060052)2.50658290
145neuronal action potential propagation (GO:0019227)2.49778652
146positive regulation of dendritic spine morphogenesis (GO:0061003)2.49585884
147regulation of synapse maturation (GO:0090128)2.48378233
148postsynaptic membrane organization (GO:0001941)2.47379787
149regulation of synaptic plasticity (GO:0048167)2.46413763
150regulation of neurotransmitter secretion (GO:0046928)2.46109733
151gamma-aminobutyric acid signaling pathway (GO:0007214)2.45862960
152ganglion development (GO:0061548)2.44894500
153nervous system development (GO:0007399)2.44660164
154* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.44241564
155negative regulation of axonogenesis (GO:0050771)2.43439225
156negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.42747463
157neurotransmitter transport (GO:0006836)2.42082967
158negative regulation of sodium ion transport (GO:0010766)2.41973954
159generation of neurons (GO:0048699)2.40428022
160cytoskeleton-dependent intracellular transport (GO:0030705)2.40198752
161positive regulation of potassium ion transport (GO:0043268)2.40063752
162regulation of voltage-gated calcium channel activity (GO:1901385)2.39903140
163neuron projection morphogenesis (GO:0048812)2.39318878

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.61368839
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.95027118
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89834861
4DROSHA_22980978_ChIP-Seq_HELA_Human2.80576352
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.76951743
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.68308589
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67949919
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67949919
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56506543
10* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47665670
11GBX2_23144817_ChIP-Seq_PC3_Human2.40866212
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40125141
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.39385160
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37808762
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.35589746
16TAF15_26573619_Chip-Seq_HEK293_Human2.35201813
17* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.34937307
18* EZH2_27304074_Chip-Seq_ESCs_Mouse2.34160329
19IGF1R_20145208_ChIP-Seq_DFB_Human2.32043443
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.29473741
21* EED_16625203_ChIP-ChIP_MESCs_Mouse2.25131335
22* RNF2_27304074_Chip-Seq_ESCs_Mouse2.23442791
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23121303
24* EZH2_27294783_Chip-Seq_ESCs_Mouse2.21669286
25RARB_27405468_Chip-Seq_BRAIN_Mouse2.20002072
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.15861411
27* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14916828
28REST_21632747_ChIP-Seq_MESCs_Mouse2.05836359
29RNF2_27304074_Chip-Seq_NSC_Mouse2.04608579
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88412914
31AR_21572438_ChIP-Seq_LNCaP_Human1.80363196
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.75366068
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.74674803
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69051050
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.68094170
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64138474
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62785347
38P300_19829295_ChIP-Seq_ESCs_Human1.62719459
39KDM2B_26808549_Chip-Seq_K562_Human1.56284001
40ZFP281_18757296_ChIP-ChIP_E14_Mouse1.55644445
41KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.53994159
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.52242260
43SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51894034
44WT1_25993318_ChIP-Seq_PODOCYTE_Human1.51868410
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51721561
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49888459
47* RING1B_27294783_Chip-Seq_ESCs_Mouse1.49498348
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47125800
49VDR_22108803_ChIP-Seq_LS180_Human1.46059444
50DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.45284504
51EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44888927
52* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44587663
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44534640
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43700555
55TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42859333
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42533052
57* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38682734
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38356432
59RING1B_27294783_Chip-Seq_NPCs_Mouse1.36838338
60ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36356194
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36034628
62EWS_26573619_Chip-Seq_HEK293_Human1.35806790
63ZNF274_21170338_ChIP-Seq_K562_Hela1.35107810
64FUS_26573619_Chip-Seq_HEK293_Human1.35031941
65ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34918991
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34833146
67WT1_19549856_ChIP-ChIP_CCG9911_Human1.33856301
68AR_19668381_ChIP-Seq_PC3_Human1.32347299
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.30573919
70EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30362241
71* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29781442
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29651185
73DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25795923
74TRIM28_21343339_ChIP-Seq_HEK293_Human1.25568899
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25077084
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.24302174
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23783819
78SMAD4_21799915_ChIP-Seq_A2780_Human1.22720988
79SOX2_21211035_ChIP-Seq_LN229_Gbm1.21671201
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21233320
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20919458
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20688898
83HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19759735
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19092020
85NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16486187
86OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.16422727
87STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14977120
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14947877
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14947877
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14536262
91YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14110797
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13319912
93EP300_21415370_ChIP-Seq_HL-1_Mouse1.12763642
94AHR_22903824_ChIP-Seq_MCF-7_Human1.12077075
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.11735886
96RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09430723
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08362326
98SMAD_19615063_ChIP-ChIP_OVARY_Human1.08266556
99RUNX2_22187159_ChIP-Seq_PCA_Human1.06379162
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06304365
101TP53_16413492_ChIP-PET_HCT116_Human1.06242737
102SMAD4_21741376_ChIP-Seq_HESCs_Human1.05598845
103TBX3_20139965_ChIP-Seq_MESCs_Mouse1.05454107
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04706145
105MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04535625
106TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04065266
107CBX2_27304074_Chip-Seq_ESCs_Mouse1.03394622
108* TP53_20018659_ChIP-ChIP_R1E_Mouse1.03063279
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02842474
110KDM2B_26808549_Chip-Seq_JURKAT_Human1.02063823
111FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02015663
112PIAS1_25552417_ChIP-Seq_VCAP_Human1.00967699
113ISL1_27105846_Chip-Seq_CPCs_Mouse1.00689688
114SOX9_26525672_Chip-Seq_HEART_Mouse0.99958902
115AR_25329375_ChIP-Seq_VCAP_Human0.99693432
116GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99684325
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99202233
118THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98664278
119NANOG_18555785_Chip-Seq_ESCs_Mouse0.98140386
120SMAD3_21741376_ChIP-Seq_HESCs_Human0.98087421
121STAT3_23295773_ChIP-Seq_U87_Human0.97645868
122SMAD3_21741376_ChIP-Seq_EPCs_Human0.97295721
123SOX2_16153702_ChIP-ChIP_HESCs_Human0.96811396
124SMAD3_21741376_ChIP-Seq_ESCs_Human0.95831693
125RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95795090
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95754201
127TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95493821
128TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95177360
129ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95122796
130CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94069458
131P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93680968
132ESR2_21235772_ChIP-Seq_MCF-7_Human0.92267359
133MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92172222
134STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91945781
135KDM2B_26808549_Chip-Seq_DND41_Human0.91921734
136BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91182251
137CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90122289
138SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88335443
139OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88209462
140TET1_21490601_ChIP-Seq_MESCs_Mouse0.86022036
141RXR_22108803_ChIP-Seq_LS180_Human0.85795509
142NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85791927

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.54577745
2MP0003635_abnormal_synaptic_transmissio3.36114209
3MP0004270_analgesia2.82227562
4MP0002063_abnormal_learning/memory/cond2.58775444
5MP0009780_abnormal_chondrocyte_physiolo2.47098327
6MP0006276_abnormal_autonomic_nervous2.43391676
7MP0003880_abnormal_central_pattern2.39832384
8MP0005423_abnormal_somatic_nervous2.37321635
9MP0009046_muscle_twitch2.30856372
10MP0009745_abnormal_behavioral_response2.29230421
11MP0004858_abnormal_nervous_system2.28564456
12MP0002064_seizures2.19270473
13MP0003121_genomic_imprinting2.13573363
14MP0000778_abnormal_nervous_system2.06965253
15MP0001529_abnormal_vocalization2.03487035
16MP0001486_abnormal_startle_reflex2.02901635
17MP0008569_lethality_at_weaning1.97532257
18MP0002572_abnormal_emotion/affect_behav1.95362026
19MP0003329_amyloid_beta_deposits1.94507954
20MP0002734_abnormal_mechanical_nocicepti1.94327252
21MP0002909_abnormal_adrenal_gland1.92361026
22MP0002822_catalepsy1.89430095
23MP0002184_abnormal_innervation1.89183764
24MP0002638_abnormal_pupillary_reflex1.79142231
25MP0001968_abnormal_touch/_nociception1.76994312
26MP0002272_abnormal_nervous_system1.73246340
27MP0003283_abnormal_digestive_organ1.70822052
28MP0004233_abnormal_muscle_weight1.69838511
29MP0001188_hyperpigmentation1.68907114
30MP0002102_abnormal_ear_morphology1.68271372
31MP0000751_myopathy1.63912777
32MP0000013_abnormal_adipose_tissue1.62102127
33MP0004811_abnormal_neuron_physiology1.61480948
34MP0004133_heterotaxia1.57706668
35MP0000955_abnormal_spinal_cord1.53916778
36MP0002557_abnormal_social/conspecific_i1.52467858
37MP0000049_abnormal_middle_ear1.50522160
38MP0004885_abnormal_endolymph1.50012576
39MP0001177_atelectasis1.48569278
40MP0003705_abnormal_hypodermis_morpholog1.48006421
41MP0001502_abnormal_circadian_rhythm1.46661772
42MP0002067_abnormal_sensory_capabilities1.45240497
43MP0005623_abnormal_meninges_morphology1.44462159
44MP0001984_abnormal_olfaction1.44191058
45MP0001299_abnormal_eye_distance/1.41122974
46MP0008789_abnormal_olfactory_epithelium1.39573805
47MP0002882_abnormal_neuron_morphology1.39524646
48MP0002090_abnormal_vision1.37065546
49MP0002089_abnormal_postnatal_growth/wei1.35891174
50MP0005187_abnormal_penis_morphology1.35228547
51MP0000569_abnormal_digit_pigmentation1.35012430
52MP0002733_abnormal_thermal_nociception1.34231183
53MP0005551_abnormal_eye_electrophysiolog1.32808622
54MP0006072_abnormal_retinal_apoptosis1.32020216
55MP0008961_abnormal_basal_metabolism1.30251505
56MP0003122_maternal_imprinting1.29582039
57MP0004142_abnormal_muscle_tone1.28737549
58MP0010030_abnormal_orbit_morphology1.27230344
59MP0001970_abnormal_pain_threshold1.27034619
60MP0003119_abnormal_digestive_system1.26039753
61MP0001879_abnormal_lymphatic_vessel1.25480573
62MP0001501_abnormal_sleep_pattern1.25458463
63MP0002751_abnormal_autonomic_nervous1.24863220
64MP0000534_abnormal_ureter_morphology1.24849843
65MP0001440_abnormal_grooming_behavior1.24472322
66MP0004145_abnormal_muscle_electrophysio1.23950457
67MP0005386_behavior/neurological_phenoty1.22565632
68MP0004924_abnormal_behavior1.22565632
69MP0005646_abnormal_pituitary_gland1.20083978
70MP0002152_abnormal_brain_morphology1.19393602
71MP0002233_abnormal_nose_morphology1.18457052
72MP0003634_abnormal_glial_cell1.15574248
73MP0010368_abnormal_lymphatic_system1.15410247
74MP0003938_abnormal_ear_development1.14798766
75MP0002735_abnormal_chemical_nociception1.12743177
76MP0003937_abnormal_limbs/digits/tail_de1.12155119
77MP0003633_abnormal_nervous_system1.11745771
78MP0001293_anophthalmia1.10681033
79MP0000026_abnormal_inner_ear1.10389523
80MP0004215_abnormal_myocardial_fiber1.09872605
81MP0002736_abnormal_nociception_after1.09140175
82MP0005257_abnormal_intraocular_pressure1.09012455
83MP0002066_abnormal_motor_capabilities/c1.08903019
84MP0008438_abnormal_cutaneous_collagen1.08545270
85MP0003137_abnormal_impulse_conducting1.07613005
86MP0002653_abnormal_ependyma_morphology1.06409714
87MP0000003_abnormal_adipose_tissue1.06010405
88MP0005503_abnormal_tendon_morphology1.04775680
89MP0005377_hearing/vestibular/ear_phenot1.03935833
90MP0003878_abnormal_ear_physiology1.03935833
91MP0004085_abnormal_heartbeat1.02860639
92MP0000631_abnormal_neuroendocrine_gland1.02628732
93MP0006292_abnormal_olfactory_placode1.00638836
94MP0003045_fibrosis0.99236669
95MP0002697_abnormal_eye_size0.98885897
96MP0003136_yellow_coat_color0.98242776
97MP0005394_taste/olfaction_phenotype0.97961083
98MP0005499_abnormal_olfactory_system0.97961083
99MP0003755_abnormal_palate_morphology0.94889071
100MP0003631_nervous_system_phenotype0.93143780
101MP0003385_abnormal_body_wall0.92253375
102MP0000537_abnormal_urethra_morphology0.91810785
103MP0001905_abnormal_dopamine_level0.90327698
104MP0002938_white_spotting0.89033461
105MP0005645_abnormal_hypothalamus_physiol0.88289565
106MP0002081_perinatal_lethality0.87777051
107MP0003632_abnormal_nervous_system0.86686029
108MP0003861_abnormal_nervous_system0.86670858
109MP0003690_abnormal_glial_cell0.86591291
110MP0000516_abnormal_urinary_system0.86397924
111MP0005367_renal/urinary_system_phenotyp0.86397924
112MP0002234_abnormal_pharynx_morphology0.86088308
113MP0003279_aneurysm0.85433757
114MP0004272_abnormal_basement_membrane0.85183811
115MP0004084_abnormal_cardiac_muscle0.83479839
116MP0002116_abnormal_craniofacial_bone0.82840879
117MP0005391_vision/eye_phenotype0.81811354
118MP0005195_abnormal_posterior_eye0.81604654
119MP0001542_abnormal_bone_strength0.81084882
120MP0005253_abnormal_eye_physiology0.80856312
121MP0002108_abnormal_muscle_morphology0.80604449
122MP0003890_abnormal_embryonic-extraembry0.79613167
123MP0003935_abnormal_craniofacial_develop0.79471516
124MP0003879_abnormal_hair_cell0.79097243
125MP0003787_abnormal_imprinting0.78314632
126MP0001958_emphysema0.77684432
127MP0000428_abnormal_craniofacial_morphol0.77177900
128MP0000604_amyloidosis0.76410493
129MP0005248_abnormal_Harderian_gland0.76173783
130MP0003115_abnormal_respiratory_system0.76106183
131MP0002752_abnormal_somatic_nervous0.74147019
132MP0002896_abnormal_bone_mineralization0.73139345
133MP0003942_abnormal_urinary_system0.70970044
134MP0003075_altered_response_to0.70018427
135MP0002069_abnormal_eating/drinking_beha0.69767476
136MP0005595_abnormal_vascular_smooth0.69753526
137MP0001943_abnormal_respiration0.66397427

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)3.99991266
2Morphological abnormality of the middle ear (HP:0008609)3.77705602
3Action tremor (HP:0002345)3.55813055
4Polyphagia (HP:0002591)3.31750317
5Focal seizures (HP:0007359)3.20224503
6Shallow orbits (HP:0000586)3.15395709
7Cortical dysplasia (HP:0002539)3.11476024
8Visual hallucinations (HP:0002367)3.10348824
9Short 4th metacarpal (HP:0010044)3.07090609
10Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.07090609
11Vitreoretinal degeneration (HP:0000655)3.04303043
12Progressive cerebellar ataxia (HP:0002073)3.02366371
13Focal motor seizures (HP:0011153)3.01568282
14Limb dystonia (HP:0002451)2.96905764
15Megalencephaly (HP:0001355)2.93257230
16Broad metatarsal (HP:0001783)2.89650343
17Neonatal short-limb short stature (HP:0008921)2.85094596
18Lissencephaly (HP:0001339)2.84146826
19Pachygyria (HP:0001302)2.83511629
20Hypoplasia of the brainstem (HP:0002365)2.83281052
21Aplasia/Hypoplasia of the brainstem (HP:0007362)2.83281052
22Hemiplegia (HP:0002301)2.72435150
23Gait imbalance (HP:0002141)2.70087013
24Cutaneous finger syndactyly (HP:0010554)2.54431031
25Abnormality of the 4th metacarpal (HP:0010012)2.52851634
26Ankle clonus (HP:0011448)2.52505218
27Exotropia (HP:0000577)2.49915378
28Hyperacusis (HP:0010780)2.48981766
29Epileptic encephalopathy (HP:0200134)2.48891434
30Insomnia (HP:0100785)2.47402989
31Hemiparesis (HP:0001269)2.45175466
32Genetic anticipation (HP:0003743)2.44446728
33Depression (HP:0000716)2.44201313
34Abnormality of the ischium (HP:0003174)2.42547438
35Neoplasm of the heart (HP:0100544)2.39972476
36Arterial tortuosity (HP:0005116)2.38878361
37Cerebral aneurysm (HP:0004944)2.37386950
38Elfin facies (HP:0004428)2.34042251
39Central scotoma (HP:0000603)2.33817112
40Supranuclear gaze palsy (HP:0000605)2.32535105
41Pointed chin (HP:0000307)2.32225931
42Pheochromocytoma (HP:0002666)2.31988188
43Truncal ataxia (HP:0002078)2.29899399
44Wide anterior fontanel (HP:0000260)2.29650039
45Cutaneous syndactyly (HP:0012725)2.25465608
46Vascular tortuosity (HP:0004948)2.19319405
47Esotropia (HP:0000565)2.17691561
48True hermaphroditism (HP:0010459)2.17493803
49Dysdiadochokinesis (HP:0002075)2.17059421
50Mild short stature (HP:0003502)2.16098652
51Protrusio acetabuli (HP:0003179)2.13676957
52Medial flaring of the eyebrow (HP:0010747)2.11705020
53Failure to thrive in infancy (HP:0001531)2.11390505
54Prolonged QT interval (HP:0001657)2.10899403
55Macroorchidism (HP:0000053)2.10690686
56Amyotrophic lateral sclerosis (HP:0007354)2.10303454
57Pancreatic fibrosis (HP:0100732)2.09613048
58Genital tract atresia (HP:0001827)2.09351951
59Trigonocephaly (HP:0000243)2.08904528
60Abnormality of dentin (HP:0010299)2.08362753
61Congenital primary aphakia (HP:0007707)2.07981867
62Bladder diverticulum (HP:0000015)2.07912792
63Congenital stationary night blindness (HP:0007642)2.07748750
64Hepatoblastoma (HP:0002884)2.07421329
65Abnormality of the labia minora (HP:0012880)2.06557559
66Specific learning disability (HP:0001328)2.06320295
67Scotoma (HP:0000575)2.06270741
68Vaginal atresia (HP:0000148)2.06240623
69Dysmetric saccades (HP:0000641)2.06067347
70Shawl scrotum (HP:0000049)2.05276414
71Renal duplication (HP:0000075)2.04980424
72Absent speech (HP:0001344)2.04686122
73High anterior hairline (HP:0009890)2.03852697
74Renovascular hypertension (HP:0100817)2.03709114
75Torticollis (HP:0000473)2.03274417
76Genu recurvatum (HP:0002816)2.02998674
77Absence seizures (HP:0002121)2.02713816
78Abnormality of the corticospinal tract (HP:0002492)2.02313345
79Neuroendocrine neoplasm (HP:0100634)2.00326484
80Poor eye contact (HP:0000817)1.99131323
81Atrophic scars (HP:0001075)1.98830057
82Delayed gross motor development (HP:0002194)1.98537201
83Abnormality of the lower motor neuron (HP:0002366)1.98517663
84Pancreatic cysts (HP:0001737)1.98319564
85Bowel diverticulosis (HP:0005222)1.98123416
86Optic nerve hypoplasia (HP:0000609)1.97548871
87Nephronophthisis (HP:0000090)1.97337172
88Flat cornea (HP:0007720)1.96815354
89Overriding aorta (HP:0002623)1.96059905
90Excessive salivation (HP:0003781)1.95966073
91Drooling (HP:0002307)1.95966073
92Soft skin (HP:0000977)1.94966348
93Nephrogenic diabetes insipidus (HP:0009806)1.94824962
94Amblyopia (HP:0000646)1.93836140
95Broad-based gait (HP:0002136)1.93672990
96Impaired social interactions (HP:0000735)1.93597038
97Abnormal social behavior (HP:0012433)1.93597038
98Mutism (HP:0002300)1.92937147
99Aplasia involving bones of the upper limbs (HP:0009823)1.92869327
100Aplasia of the phalanges of the hand (HP:0009802)1.92869327
101Aplasia involving bones of the extremities (HP:0009825)1.92869327
102Agitation (HP:0000713)1.92169139
103Abnormality of the diencephalon (HP:0010662)1.90826024
104Atonic seizures (HP:0010819)1.89687774
105Septo-optic dysplasia (HP:0100842)1.88467351
106Hypoplasia of the corpus callosum (HP:0002079)1.87385799
107Intention tremor (HP:0002080)1.87294409
108Hyperventilation (HP:0002883)1.86386239
109Neurofibrillary tangles (HP:0002185)1.86383736
110Broad ribs (HP:0000885)1.86022500
111Renal hypoplasia (HP:0000089)1.85627073
112Urinary bladder sphincter dysfunction (HP:0002839)1.84982627
113Abnormality of binocular vision (HP:0011514)1.84703919
114Diplopia (HP:0000651)1.84703919
115Vertebral arch anomaly (HP:0008438)1.84034870
116Postural instability (HP:0002172)1.83334707
117Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.83010542
118Febrile seizures (HP:0002373)1.82583626
119Impaired smooth pursuit (HP:0007772)1.82557062
120Impaired vibration sensation in the lower limbs (HP:0002166)1.81618058
121Anxiety (HP:0000739)1.81601283
122Generalized tonic-clonic seizures (HP:0002069)1.81038345
123Type II lissencephaly (HP:0007260)1.80309553
124Gaze-evoked nystagmus (HP:0000640)1.79722907
125Short foot (HP:0001773)1.79616963
126Hypoventilation (HP:0002791)1.79488008
127Keratoconus (HP:0000563)1.79380355
128Increased corneal curvature (HP:0100692)1.79380355
129Scanning speech (HP:0002168)1.78931251
130Calcaneovalgus deformity (HP:0001848)1.77641123
131Buphthalmos (HP:0000557)1.77551262
132Narrow forehead (HP:0000341)1.77460713
133Narrow palate (HP:0000189)1.77279929
134Molar tooth sign on MRI (HP:0002419)1.76574534
135Abnormality of midbrain morphology (HP:0002418)1.76574534
136Cerebral inclusion bodies (HP:0100314)1.76227282
137EEG with generalized epileptiform discharges (HP:0011198)1.75483025
138Hypoplastic ischia (HP:0003175)1.75363830
139Dilatation of the ascending aorta (HP:0005111)1.75064733
140Annular pancreas (HP:0001734)1.74782165
141Stereotypic behavior (HP:0000733)1.74067136
142Postaxial hand polydactyly (HP:0001162)1.73828315
143Papilledema (HP:0001085)1.73237738
144Abnormal eating behavior (HP:0100738)1.72884787
145Ankyloglossia (HP:0010296)1.72207352
146Morphological abnormality of the pyramidal tract (HP:0002062)1.71812565
147Ventricular fibrillation (HP:0001663)1.71762032
148Infantile muscular hypotonia (HP:0008947)1.71323897
149Aqueductal stenosis (HP:0002410)1.70814100
150Spastic tetraplegia (HP:0002510)1.70719535
151Abnormality of the renal medulla (HP:0100957)1.70666906
152Hammertoe (HP:0001765)1.70470045
153Abnormal EKG (HP:0003115)1.69991547
154Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.69856604
155Short tibia (HP:0005736)1.69852394
156Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.69823219
157Epileptiform EEG discharges (HP:0011182)1.69080187
158Retinal dysplasia (HP:0007973)1.68976276
159Urinary urgency (HP:0000012)1.68783155
160Overgrowth (HP:0001548)1.68567449
161Anencephaly (HP:0002323)1.68276886
162Bronchomalacia (HP:0002780)1.67223848
163Hypsarrhythmia (HP:0002521)1.67073083
164Deformed tarsal bones (HP:0008119)1.66970377
165Lymphangioma (HP:0100764)1.66923398
166Dialeptic seizures (HP:0011146)1.66211904
167Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66119687
168Abnormality of ocular smooth pursuit (HP:0000617)1.65691207
169Micropenis (HP:0000054)1.65665439
170Lower limb muscle weakness (HP:0007340)1.65083227
171Focal dystonia (HP:0004373)1.64953769

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.44185156
2MARK13.75583293
3BCR3.38560945
4CAMKK12.71128505
5NTRK32.70833348
6EPHA42.69196069
7PRKD32.53145589
8DYRK22.47548514
9MAP3K92.44447182
10NTRK22.42966227
11PAK62.40326607
12MAP3K42.21241763
13RIPK12.19707848
14LMTK22.19374941
15MINK12.18764756
16PHKG12.12451874
17PHKG22.12451874
18TRIB32.12122317
19CSNK1G22.02331499
20PASK1.89174605
21PKN21.84013953
22DAPK21.77829655
23TRIM281.75613079
24WNK31.63448734
25SIK11.62202374
26SIK21.59815715
27KSR11.56498056
28MAP4K21.52855137
29NTRK11.45756959
30PDGFRA1.43875234
31TYRO31.39679112
32KSR21.38267141
33STK381.36162772
34PRPF4B1.34886105
35PINK11.33557604
36CSNK1G31.32870987
37FGFR21.30456497
38CDK51.25013230
39CSNK1A1L1.24811931
40MAPK131.24394677
41RET1.21075531
42CSNK1G11.19968850
43ERBB31.18703505
44TIE11.16361578
45DDR21.15959464
46CAMK1G1.14924381
47PRKCH1.14556971
48BMPR1B1.13746095
49SGK4941.11332745
50SGK2231.11332745
51PAK31.08277083
52LATS21.06302430
53EPHB21.05359108
54SGK31.05246050
55SGK21.02796311
56MARK21.00254125
57EPHA30.95682199
58PNCK0.95225546
59CAMKK20.94491257
60RPS6KA40.92647139
61MOS0.91153411
62UHMK10.90796888
63SCYL20.87926233
64ADRBK20.84018404
65TAOK10.82803887
66PTK60.81268143
67WNK10.81238348
68TNIK0.81133088
69MAP2K40.80449373
70MAP3K20.80438050
71BRD40.80247402
72DYRK1A0.79011862
73CDC42BPA0.77967351
74PRKCE0.77336083
75FER0.76163639
76ALK0.75624298
77MAP2K70.74438764
78FGFR10.74373531
79STK110.73622396
80DMPK0.73450726
81ERBB20.73081416
82PRKCG0.72927973
83ROCK10.71082683
84ICK0.70910240
85CAMK40.66567718
86MAP3K60.66433981
87DYRK1B0.65703782
88CAMK1D0.65681018
89CDK140.65167435
90ROCK20.64488391
91CDK180.63956422
92CDK150.63583931
93NEK20.63576583
94PTK20.63155674
95PKN10.61478146
96PRKCZ0.61234441
97INSRR0.60851652
98EPHB10.60709862
99MAP3K70.60310822
100PDGFRB0.59425641
101MKNK20.59089174
102CDK190.59029316
103CAMK10.58970280
104TAOK20.58926691
105STK390.58474136
106PLK20.58179632
107SGK10.57449914
108DYRK30.56580256
109FYN0.55508881
110STK38L0.55199783
111CAMK2A0.51823933
112BMX0.51595482
113CDK11A0.51381596
114GRK10.51149812
115RPS6KA30.49279929
116WNK40.48397308
117RPS6KA20.47883178
118EEF2K0.47793921
119CSNK1D0.47602226
120NEK10.46812140
121MAPK100.46770101
122FES0.46548854
123DAPK10.45675762
124FGFR30.45517124
125PTK2B0.45440719
126SIK30.45281803
127PRKD10.43539827
128BCKDK0.42925646
129TTN0.42364136
130CAMK2B0.42209638
131MKNK10.42167356
132HIPK20.41577446
133CAMK2D0.41219850
134LATS10.41157034
135SRPK10.38830602
136PRKAA10.38529150
137MAPK90.37840924
138PRKACB0.33770473
139CSNK1E0.32566808
140CSNK1A10.32342940
141ADRBK10.32170782
142FRK0.28743752
143PRKG10.28636766
144OXSR10.27914069
145RPS6KB10.25976922
146CDK30.25559537
147RPS6KA50.25328145

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.65467287
2Circadian entrainment_Homo sapiens_hsa047132.29745823
3GABAergic synapse_Homo sapiens_hsa047272.28368835
4Synaptic vesicle cycle_Homo sapiens_hsa047212.19588529
5Glutamatergic synapse_Homo sapiens_hsa047242.08652741
6Morphine addiction_Homo sapiens_hsa050322.05775713
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.03666181
8Olfactory transduction_Homo sapiens_hsa047402.03219382
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.00264545
10Insulin secretion_Homo sapiens_hsa049111.91973199
11Long-term potentiation_Homo sapiens_hsa047201.88487219
12Amphetamine addiction_Homo sapiens_hsa050311.78425666
13Salivary secretion_Homo sapiens_hsa049701.78283127
14Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78094387
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72900776
16Dopaminergic synapse_Homo sapiens_hsa047281.72009175
17Cholinergic synapse_Homo sapiens_hsa047251.69873120
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69417916
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.64250663
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.64213399
21Gastric acid secretion_Homo sapiens_hsa049711.60941664
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.60033937
23Cocaine addiction_Homo sapiens_hsa050301.59201663
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.58966157
25Renin secretion_Homo sapiens_hsa049241.54902318
26Oxytocin signaling pathway_Homo sapiens_hsa049211.48378244
27Type II diabetes mellitus_Homo sapiens_hsa049301.46636616
28Axon guidance_Homo sapiens_hsa043601.43825002
29Steroid biosynthesis_Homo sapiens_hsa001001.43578819
30Gap junction_Homo sapiens_hsa045401.42355014
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.40657830
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.36453244
33Dilated cardiomyopathy_Homo sapiens_hsa054141.33804082
34GnRH signaling pathway_Homo sapiens_hsa049121.33502132
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.31824522
36cAMP signaling pathway_Homo sapiens_hsa040241.29970687
37Long-term depression_Homo sapiens_hsa047301.26858072
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24930915
39Calcium signaling pathway_Homo sapiens_hsa040201.24750855
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.21064505
41Estrogen signaling pathway_Homo sapiens_hsa049151.19753987
42Glioma_Homo sapiens_hsa052141.19561897
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17807561
44Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.14992492
45Taste transduction_Homo sapiens_hsa047421.14010628
46Nitrogen metabolism_Homo sapiens_hsa009101.09998549
47Melanogenesis_Homo sapiens_hsa049161.09181014
48Butanoate metabolism_Homo sapiens_hsa006501.08236470
49Serotonergic synapse_Homo sapiens_hsa047261.06989706
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06860884
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06193937
52Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05689633
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04173104
54Protein export_Homo sapiens_hsa030601.04103197
55Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03729544
56ErbB signaling pathway_Homo sapiens_hsa040121.02045506
57Dorso-ventral axis formation_Homo sapiens_hsa043201.00110524
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96593147
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.95950935
60mTOR signaling pathway_Homo sapiens_hsa041500.94353282
61Endometrial cancer_Homo sapiens_hsa052130.94183648
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93745573
63Adherens junction_Homo sapiens_hsa045200.93293281
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.92936675
65Thyroid hormone synthesis_Homo sapiens_hsa049180.87135313
66Circadian rhythm_Homo sapiens_hsa047100.85117749
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84146834
68Pancreatic secretion_Homo sapiens_hsa049720.82737215
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.82213686
70Renal cell carcinoma_Homo sapiens_hsa052110.81056105
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.80046801
72Basal cell carcinoma_Homo sapiens_hsa052170.79756233
73Hedgehog signaling pathway_Homo sapiens_hsa043400.76336955
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75935782
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75732729
76Rap1 signaling pathway_Homo sapiens_hsa040150.75635328
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75124743
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74717163
79Colorectal cancer_Homo sapiens_hsa052100.74549618
80MAPK signaling pathway_Homo sapiens_hsa040100.73101306
81VEGF signaling pathway_Homo sapiens_hsa043700.73091803
82Wnt signaling pathway_Homo sapiens_hsa043100.72297835
83Focal adhesion_Homo sapiens_hsa045100.72160697
84Proteoglycans in cancer_Homo sapiens_hsa052050.71540625
85Choline metabolism in cancer_Homo sapiens_hsa052310.71377435
86Fatty acid biosynthesis_Homo sapiens_hsa000610.71206963
87Hippo signaling pathway_Homo sapiens_hsa043900.70750647
88Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70398554
89Phototransduction_Homo sapiens_hsa047440.70221033
90Notch signaling pathway_Homo sapiens_hsa043300.68328411
91Glucagon signaling pathway_Homo sapiens_hsa049220.67041182
92Non-small cell lung cancer_Homo sapiens_hsa052230.66786254
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.66445493
94Vibrio cholerae infection_Homo sapiens_hsa051100.63659617
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62359228
96Endocytosis_Homo sapiens_hsa041440.61393833
97Propanoate metabolism_Homo sapiens_hsa006400.61247215
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60053709
99Bile secretion_Homo sapiens_hsa049760.60049470
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59176372
101Oocyte meiosis_Homo sapiens_hsa041140.58812747
102Insulin signaling pathway_Homo sapiens_hsa049100.57547299
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56390760
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54548089
105PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53925495
106Insulin resistance_Homo sapiens_hsa049310.53807411
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.52974548
108Ras signaling pathway_Homo sapiens_hsa040140.52837704
109Collecting duct acid secretion_Homo sapiens_hsa049660.52705042
110ECM-receptor interaction_Homo sapiens_hsa045120.52066214
111Chronic myeloid leukemia_Homo sapiens_hsa052200.51037595
112Ether lipid metabolism_Homo sapiens_hsa005650.50559076
113AMPK signaling pathway_Homo sapiens_hsa041520.49977479
114Cardiac muscle contraction_Homo sapiens_hsa042600.48481396
115Inositol phosphate metabolism_Homo sapiens_hsa005620.47842804
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47398898
117Amoebiasis_Homo sapiens_hsa051460.47387407
118Alcoholism_Homo sapiens_hsa050340.47227952
119Tight junction_Homo sapiens_hsa045300.46968405
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46409440
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45741174
122Pancreatic cancer_Homo sapiens_hsa052120.45264259
123Protein digestion and absorption_Homo sapiens_hsa049740.44089526
124Pathways in cancer_Homo sapiens_hsa052000.42909251
125Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42275225
126Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41386366
127Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40722400
128Melanoma_Homo sapiens_hsa052180.38907788
129Fatty acid metabolism_Homo sapiens_hsa012120.38401831
130Alzheimers disease_Homo sapiens_hsa050100.38176105
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36051405
132Linoleic acid metabolism_Homo sapiens_hsa005910.35913726
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34061550

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