PCDHGB7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1postsynaptic membrane organization (GO:0001941)4.82280058
2dendritic spine morphogenesis (GO:0060997)4.77913490
3negative regulation of cytosolic calcium ion concentration (GO:0051481)4.76948705
4response to pheromone (GO:0019236)4.75946177
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.68257812
6axonal fasciculation (GO:0007413)4.50227796
7presynaptic membrane assembly (GO:0097105)4.45622687
8locomotory exploration behavior (GO:0035641)4.35887894
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.21002446
10sodium ion export (GO:0071436)4.11567472
11regulation of synapse structural plasticity (GO:0051823)4.10306712
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.04576192
13membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.00732130
14synaptic vesicle maturation (GO:0016188)4.00090981
15presynaptic membrane organization (GO:0097090)3.89853037
16cell communication by electrical coupling (GO:0010644)3.88276288
17dermatan sulfate biosynthetic process (GO:0030208)3.87139205
18central nervous system projection neuron axonogenesis (GO:0021952)3.80627294
19auditory behavior (GO:0031223)3.77040443
20cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.74874388
21vocalization behavior (GO:0071625)3.68445365
22dermatan sulfate metabolic process (GO:0030205)3.67675315
23regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.64232382
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.61806875
25protein heterotrimerization (GO:0070208)3.60991169
26cell migration in hindbrain (GO:0021535)3.60149378
27cellular potassium ion homeostasis (GO:0030007)3.59062142
28neuron recognition (GO:0008038)3.57297240
29layer formation in cerebral cortex (GO:0021819)3.55120732
30synaptic vesicle exocytosis (GO:0016079)3.49363350
31dendrite morphogenesis (GO:0048813)3.46980695
32positive regulation of synapse maturation (GO:0090129)3.43892121
33regulation of long-term neuronal synaptic plasticity (GO:0048169)3.38611697
34response to auditory stimulus (GO:0010996)3.38251458
35lung epithelium development (GO:0060428)3.37664516
36glutamate secretion (GO:0014047)3.29908241
37endocardial cushion morphogenesis (GO:0003203)3.29853061
38regulation of glutamate receptor signaling pathway (GO:1900449)3.29471348
39regulation of neuronal synaptic plasticity (GO:0048168)3.28607190
40synaptic vesicle endocytosis (GO:0048488)3.27891336
41exploration behavior (GO:0035640)3.26204295
42innervation (GO:0060384)3.26065964
43protein localization to synapse (GO:0035418)3.24505121
44neuronal action potential propagation (GO:0019227)3.21729928
45regulation of synaptic vesicle exocytosis (GO:2000300)3.17953019
46axon extension (GO:0048675)3.15129005
47synaptic vesicle docking involved in exocytosis (GO:0016081)3.14175016
48neurotransmitter secretion (GO:0007269)3.13129924
49G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.11191696
50calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.10193610
51neuronal ion channel clustering (GO:0045161)3.09162402
52cell migration involved in heart development (GO:0060973)3.07758242
53regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.04694149
54vascular endothelial growth factor signaling pathway (GO:0038084)3.04613681
55retinal ganglion cell axon guidance (GO:0031290)3.03908478
56dendritic spine organization (GO:0097061)3.03340691
57neurotransmitter-gated ion channel clustering (GO:0072578)3.00253728
58glutamate receptor signaling pathway (GO:0007215)2.99785172
59pyrimidine nucleobase catabolic process (GO:0006208)2.99417560
60synaptic transmission, glutamatergic (GO:0035249)2.98277245
61ionotropic glutamate receptor signaling pathway (GO:0035235)2.95550160
62neuron cell-cell adhesion (GO:0007158)2.94669546
63regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.94318762
64mesenchyme morphogenesis (GO:0072132)2.88112152
65camera-type eye morphogenesis (GO:0048593)2.87852514
66Notch signaling involved in heart development (GO:0061314)2.87571494
67coronary vasculature morphogenesis (GO:0060977)2.87191620
68* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.86118628
69chondroitin sulfate catabolic process (GO:0030207)2.86008946
70cell communication involved in cardiac conduction (GO:0086065)2.83646151
71cerebellar Purkinje cell differentiation (GO:0021702)2.83328371
72cellular sodium ion homeostasis (GO:0006883)2.82584585
73collagen fibril organization (GO:0030199)2.82449799
74synapse assembly (GO:0007416)2.80781390
75peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.80242310
76positive regulation of synapse assembly (GO:0051965)2.80157364
77membrane assembly (GO:0071709)2.80076025
78negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.79586323
79cerebellar granule cell differentiation (GO:0021707)2.79145963
80membrane hyperpolarization (GO:0060081)2.78802448
81regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.77784401
82central nervous system neuron axonogenesis (GO:0021955)2.77749603
83long-term memory (GO:0007616)2.75852553
84mechanosensory behavior (GO:0007638)2.74633582
85cell migration involved in sprouting angiogenesis (GO:0002042)2.74434733
86regulation of synapse maturation (GO:0090128)2.73955239
87astrocyte differentiation (GO:0048708)2.73866862
88peripheral nervous system axon ensheathment (GO:0032292)2.73827826
89myelination in peripheral nervous system (GO:0022011)2.73827826
90establishment of nucleus localization (GO:0040023)2.73112938
91potassium ion homeostasis (GO:0055075)2.73056750
92regulation of ARF protein signal transduction (GO:0032012)2.72998143
93gamma-aminobutyric acid signaling pathway (GO:0007214)2.71634394
94regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.71479767
95membrane depolarization during action potential (GO:0086010)2.69064155
96planar cell polarity pathway involved in neural tube closure (GO:0090179)2.67055901
97alanine transport (GO:0032328)2.66817767
98negative regulation of axon extension involved in axon guidance (GO:0048843)2.66746956
99atrial cardiac muscle cell action potential (GO:0086014)2.66554618
100neuron-neuron synaptic transmission (GO:0007270)2.66486795
101semaphorin-plexin signaling pathway (GO:0071526)2.66369009
102endodermal cell differentiation (GO:0035987)2.65852200
103positive regulation of axon extension (GO:0045773)2.65687567
104establishment of mitochondrion localization (GO:0051654)2.65604630
105proline transport (GO:0015824)2.64275593
106neuron projection extension (GO:1990138)2.64005229
107negative regulation of catenin import into nucleus (GO:0035414)2.63702465
108axon extension involved in axon guidance (GO:0048846)2.62885412
109neuron projection extension involved in neuron projection guidance (GO:1902284)2.62885412
110negative regulation of chondrocyte differentiation (GO:0032331)2.62708386
111negative regulation of axon guidance (GO:1902668)2.62705482
112regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.62138335
113potassium ion import (GO:0010107)2.61677899
114positive regulation of dendritic spine morphogenesis (GO:0061003)2.61148304
115regulation of synaptic vesicle transport (GO:1902803)2.59956000
116regulation of axon guidance (GO:1902667)2.59519814
117positive regulation of membrane potential (GO:0045838)2.56517893
118basement membrane organization (GO:0071711)2.56264656
119positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.55533383
120synapse organization (GO:0050808)2.55518527
121ganglion development (GO:0061548)2.55180646
122nucleobase catabolic process (GO:0046113)2.54638876
123regulation of dendritic spine morphogenesis (GO:0061001)2.54472116
124neuromuscular process controlling balance (GO:0050885)2.53541076
125paraxial mesoderm development (GO:0048339)2.53195992
126positive regulation of dendritic spine development (GO:0060999)2.53183083
127negative regulation of oligodendrocyte differentiation (GO:0048715)2.53174572
128gamma-aminobutyric acid transport (GO:0015812)2.52017479
129striatum development (GO:0021756)2.50335818
130regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.50150742
131bone trabecula formation (GO:0060346)2.49574267
132retina vasculature morphogenesis in camera-type eye (GO:0061299)2.49029036
133regulation of excitatory postsynaptic membrane potential (GO:0060079)2.48567434
134positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.48191624
135activation of protein kinase A activity (GO:0034199)2.47482028
136regulation of postsynaptic membrane potential (GO:0060078)2.46080619
137cerebral cortex radially oriented cell migration (GO:0021799)2.44825201
138regulation of axon extension involved in axon guidance (GO:0048841)2.41709338
139regulation of voltage-gated calcium channel activity (GO:1901385)2.41485801
140neuron projection regeneration (GO:0031102)2.41138832
141positive regulation of dendrite development (GO:1900006)2.40206229
142prepulse inhibition (GO:0060134)2.39170864
143negative chemotaxis (GO:0050919)2.39019811
144regulation of synaptic plasticity (GO:0048167)2.38950849
145cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.38917079
146neuroblast proliferation (GO:0007405)2.38715747
147astrocyte development (GO:0014002)2.37214640
148regulation of synapse assembly (GO:0051963)2.36577042
149cardiac ventricle formation (GO:0003211)2.35240272
150venous blood vessel morphogenesis (GO:0048845)2.35037635
151regulation of respiratory system process (GO:0044065)2.34682283
152lymphangiogenesis (GO:0001946)2.32511198
153suckling behavior (GO:0001967)2.31978667
154developmental cell growth (GO:0048588)2.31156797
155cerebellar Purkinje cell layer development (GO:0021680)2.30107437
156collagen metabolic process (GO:0032963)2.29267856
157negative regulation of synaptic transmission, GABAergic (GO:0032229)2.27913995
158chondroitin sulfate biosynthetic process (GO:0030206)2.27129713
159collagen catabolic process (GO:0030574)2.26998133
160skin morphogenesis (GO:0043589)2.26162843
161regulation of axon extension (GO:0030516)2.24676172
162chondrocyte proliferation (GO:0035988)2.23583718
163enteric nervous system development (GO:0048484)2.22409637
164developmental growth involved in morphogenesis (GO:0060560)2.21681126

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.04321386
2GBX2_23144817_ChIP-Seq_PC3_Human3.21643496
3* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89450778
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.86539534
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.72583427
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72581029
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72581029
8DROSHA_22980978_ChIP-Seq_HELA_Human2.72197822
9* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.70904019
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.63001015
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48883469
12* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45227608
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.41912899
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.41273861
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40897270
16* RNF2_27304074_Chip-Seq_ESCs_Mouse2.37675173
17CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.36732274
18* EED_16625203_ChIP-ChIP_MESCs_Mouse2.36124988
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.31703006
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.29798673
21* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.25967541
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.21602616
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.19227500
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19012923
25RARB_27405468_Chip-Seq_BRAIN_Mouse2.18389811
26* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17669264
27REST_21632747_ChIP-Seq_MESCs_Mouse2.11593676
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.92509235
29WT1_19549856_ChIP-ChIP_CCG9911_Human1.86032237
30AR_21572438_ChIP-Seq_LNCaP_Human1.79085920
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.71038164
32EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.65508475
33* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.63420027
34* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59669984
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55711467
36* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55274482
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55213045
38ZFP281_18757296_ChIP-ChIP_E14_Mouse1.52827512
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52491675
40NR3C1_23031785_ChIP-Seq_PC12_Mouse1.51936041
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50483859
42* RING1B_27294783_Chip-Seq_ESCs_Mouse1.49783490
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.48130022
44WT1_25993318_ChIP-Seq_PODOCYTE_Human1.47310883
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.46504586
46CLOCK_20551151_ChIP-Seq_293T_Human1.44473199
47SMAD4_21799915_ChIP-Seq_A2780_Human1.44034036
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.43499197
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.42051417
50AR_19668381_ChIP-Seq_PC3_Human1.41170406
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.39499140
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38792794
53KDM2B_26808549_Chip-Seq_K562_Human1.38225790
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37517004
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37285595
56DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.36651424
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.36321108
58RING1B_27294783_Chip-Seq_NPCs_Mouse1.35674229
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33359331
60SOX2_21211035_ChIP-Seq_LN229_Gbm1.33252821
61ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32220606
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.29123330
63YAP1_20516196_ChIP-Seq_MESCs_Mouse1.26745841
64NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.25699870
65CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25599705
66ESR1_20079471_ChIP-ChIP_T-47D_Human1.25396156
67HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24857411
68AHR_22903824_ChIP-Seq_MCF-7_Human1.24726516
69OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.24506799
70IGF1R_20145208_ChIP-Seq_DFB_Human1.22209075
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21965663
72ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21370964
73TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20426801
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20282118
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.18999827
76TP53_18474530_ChIP-ChIP_U2OS_Human1.18388498
77SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17978053
78EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16635775
79TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16598272
80SMAD4_21741376_ChIP-Seq_HESCs_Human1.16418787
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15974848
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15974717
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15312008
84NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15205031
85EP300_21415370_ChIP-Seq_HL-1_Mouse1.13944172
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.13587879
87MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12900248
88P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12810288
89ISL1_27105846_Chip-Seq_CPCs_Mouse1.12303060
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11871072
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11845777
92NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11845777
93SMAD3_21741376_ChIP-Seq_HESCs_Human1.10795265
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10236541
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08993593
96ZNF274_21170338_ChIP-Seq_K562_Hela1.08783845
97P300_19829295_ChIP-Seq_ESCs_Human1.08638424
98STAT3_23295773_ChIP-Seq_U87_Human1.08437805
99THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08185219
100STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07330606
101ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07273355
102* TP53_20018659_ChIP-ChIP_R1E_Mouse1.04997275
103KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04956840
104CJUN_26792858_Chip-Seq_BT549_Human1.04487887
105AR_25329375_ChIP-Seq_VCAP_Human1.02831992
106KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01469522
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00751592
108DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00675899
109TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98946373
110TP53_16413492_ChIP-PET_HCT116_Human0.98924252
111* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98884589
112TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97688851
113RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97687026
114TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97193460
115CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96470280
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95833458
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95600486
118BCAT_22108803_ChIP-Seq_LS180_Human0.94852061
119TP63_17297297_ChIP-ChIP_HaCaT_Human0.93987541
120CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93685907
121SMAD3_21741376_ChIP-Seq_ESCs_Human0.93591238
122* TP53_23651856_ChIP-Seq_MEFs_Mouse0.93305736
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93084666
124RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92709621
125RNF2_27304074_Chip-Seq_NSC_Mouse0.92393294
126TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91469070
127* BRD4_25478319_ChIP-Seq_HGPS_Human0.91175652
128KDM2B_26808549_Chip-Seq_JURKAT_Human0.89189411

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.98904978
2MP0008438_abnormal_cutaneous_collagen4.11502719
3MP0004272_abnormal_basement_membrane3.26681132
4MP0003635_abnormal_synaptic_transmissio2.98770922
5MP0005503_abnormal_tendon_morphology2.95655066
6MP0010368_abnormal_lymphatic_system2.77996552
7MP0003705_abnormal_hypodermis_morpholog2.64625296
8MP0001958_emphysema2.51321429
9MP0005257_abnormal_intraocular_pressure2.50198168
10MP0003880_abnormal_central_pattern2.48334140
11MP0005275_abnormal_skin_tensile2.40883176
12MP0002063_abnormal_learning/memory/cond2.39264578
13MP0003279_aneurysm2.35895410
14MP0000778_abnormal_nervous_system2.16341663
15MP0000537_abnormal_urethra_morphology2.16326094
16MP0009780_abnormal_chondrocyte_physiolo2.08917978
17MP0004270_analgesia2.07063791
18MP0004233_abnormal_muscle_weight2.06227218
19MP0002064_seizures2.02024940
20MP0001486_abnormal_startle_reflex1.98638028
21MP0005423_abnormal_somatic_nervous1.96869750
22MP0004858_abnormal_nervous_system1.96018411
23MP0005248_abnormal_Harderian_gland1.93967060
24MP0002184_abnormal_innervation1.93839107
25MP0009745_abnormal_behavioral_response1.93029286
26MP0005646_abnormal_pituitary_gland1.92248782
27MP0004145_abnormal_muscle_electrophysio1.86210992
28MP0001879_abnormal_lymphatic_vessel1.84987098
29MP0001984_abnormal_olfaction1.84456501
30MP0000751_myopathy1.80775934
31MP0000569_abnormal_digit_pigmentation1.79583900
32MP0001299_abnormal_eye_distance/1.77107355
33MP0002572_abnormal_emotion/affect_behav1.73510818
34MP0009046_muscle_twitch1.73029770
35MP0003122_maternal_imprinting1.72569579
36MP0005551_abnormal_eye_electrophysiolog1.69261935
37MP0003137_abnormal_impulse_conducting1.57509746
38MP0002734_abnormal_mechanical_nocicepti1.57455531
39MP0005394_taste/olfaction_phenotype1.55363989
40MP0005499_abnormal_olfactory_system1.55363989
41MP0002822_catalepsy1.53154574
42MP0004084_abnormal_cardiac_muscle1.51702707
43MP0002272_abnormal_nervous_system1.51701619
44MP0000955_abnormal_spinal_cord1.51089652
45MP0004215_abnormal_myocardial_fiber1.49160987
46MP0009384_cardiac_valve_regurgitation1.48998220
47MP0004885_abnormal_endolymph1.48391883
48MP0002909_abnormal_adrenal_gland1.46609803
49MP0008569_lethality_at_weaning1.46548497
50MP0003091_abnormal_cell_migration1.44908889
51MP0000534_abnormal_ureter_morphology1.41959488
52MP0002557_abnormal_social/conspecific_i1.38249669
53MP0004811_abnormal_neuron_physiology1.37911777
54MP0002882_abnormal_neuron_morphology1.37511581
55MP0002638_abnormal_pupillary_reflex1.36905235
56MP0005508_abnormal_skeleton_morphology1.34315418
57MP0002249_abnormal_larynx_morphology1.31935730
58MP0000631_abnormal_neuroendocrine_gland1.31476328
59MP0001968_abnormal_touch/_nociception1.31035345
60MP0003283_abnormal_digestive_organ1.29590563
61MP0002653_abnormal_ependyma_morphology1.29063616
62MP0002735_abnormal_chemical_nociception1.28417007
63MP0010030_abnormal_orbit_morphology1.27515090
64MP0006072_abnormal_retinal_apoptosis1.25998770
65MP0006054_spinal_hemorrhage1.24269686
66MP0010386_abnormal_urinary_bladder1.24116572
67MP0002067_abnormal_sensory_capabilities1.23563312
68MP0003942_abnormal_urinary_system1.22920064
69MP0001502_abnormal_circadian_rhythm1.22899165
70MP0000767_abnormal_smooth_muscle1.22340046
71MP0000049_abnormal_middle_ear1.21402510
72MP0002152_abnormal_brain_morphology1.20803040
73MP0000579_abnormal_nail_morphology1.20456137
74MP0008789_abnormal_olfactory_epithelium1.20393563
75MP0002837_dystrophic_cardiac_calcinosis1.19537264
76MP0003566_abnormal_cell_adhesion1.17425480
77MP0001177_atelectasis1.17163845
78MP0005253_abnormal_eye_physiology1.15677591
79MP0009250_abnormal_appendicular_skeleto1.14946406
80MP0003329_amyloid_beta_deposits1.14004903
81MP0002896_abnormal_bone_mineralization1.13430268
82MP0008961_abnormal_basal_metabolism1.13377370
83MP0004924_abnormal_behavior1.12172171
84MP0005386_behavior/neurological_phenoty1.12172171
85MP0001346_abnormal_lacrimal_gland1.11721754
86MP0005623_abnormal_meninges_morphology1.10617336
87MP0003634_abnormal_glial_cell1.10538241
88MP0005595_abnormal_vascular_smooth1.08668458
89MP0003861_abnormal_nervous_system1.07905052
90MP0002697_abnormal_eye_size1.07583398
91MP0003045_fibrosis1.06800239
92MP0003011_delayed_dark_adaptation1.04977770
93MP0000762_abnormal_tongue_morphology1.03813731
94MP0004742_abnormal_vestibular_system1.03211679
95MP0003755_abnormal_palate_morphology1.02044428
96MP0003633_abnormal_nervous_system1.01864606
97MP0002116_abnormal_craniofacial_bone1.01862988
98MP0009053_abnormal_anal_canal1.01768290
99MP0002751_abnormal_autonomic_nervous0.99492545
100MP0002295_abnormal_pulmonary_circulatio0.99323317
101MP0004085_abnormal_heartbeat0.98720955
102MP0005409_darkened_coat_color0.98405616
103MP0004036_abnormal_muscle_relaxation0.96259444
104MP0002066_abnormal_motor_capabilities/c0.96125113
105MP0000428_abnormal_craniofacial_morphol0.95566064
106MP0001542_abnormal_bone_strength0.94835380
107MP0003115_abnormal_respiratory_system0.94834254
108MP0001440_abnormal_grooming_behavior0.94389656
109MP0001849_ear_inflammation0.93921842
110MP0002752_abnormal_somatic_nervous0.93661239
111MP0005171_absent_coat_pigmentation0.93495492
112MP0002233_abnormal_nose_morphology0.93424792
113MP0002090_abnormal_vision0.93337632
114MP0001270_distended_abdomen0.91837587
115MP0001915_intracranial_hemorrhage0.91320848
116MP0002089_abnormal_postnatal_growth/wei0.91117611
117MP0002108_abnormal_muscle_morphology0.90127501
118MP0005645_abnormal_hypothalamus_physiol0.89848139
119MP0001501_abnormal_sleep_pattern0.89400928
120MP0003950_abnormal_plasma_membrane0.88968392
121MP0001970_abnormal_pain_threshold0.88812524
122MP0003690_abnormal_glial_cell0.88576192
123MP0003935_abnormal_craniofacial_develop0.88439291
124MP0006276_abnormal_autonomic_nervous0.87902981
125MP0003938_abnormal_ear_development0.85246398
126MP0002736_abnormal_nociception_after0.85233495
127MP0003385_abnormal_body_wall0.84470662
128MP0000432_abnormal_head_morphology0.82968356
129MP0003937_abnormal_limbs/digits/tail_de0.82050582
130MP0002932_abnormal_joint_morphology0.80732020
131MP0000013_abnormal_adipose_tissue0.80566538
132MP0002733_abnormal_thermal_nociception0.80525468
133MP0000733_abnormal_muscle_development0.79197428
134MP0002092_abnormal_eye_morphology0.78397844
135MP0005620_abnormal_muscle_contractility0.77677697
136MP0001188_hyperpigmentation0.77676634
137MP0000026_abnormal_inner_ear0.77168768
138MP0001529_abnormal_vocalization0.76731329
139MP0006138_congestive_heart_failure0.76565567
140MP0001324_abnormal_eye_pigmentation0.76375475
141MP0005076_abnormal_cell_differentiation0.76350919
142MP0000462_abnormal_digestive_system0.75946909
143MP0003631_nervous_system_phenotype0.75878966
144MP0002060_abnormal_skin_morphology0.75153368
145MP0002081_perinatal_lethality0.74557763
146MP0003941_abnormal_skin_development0.74301058

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.78263944
2Premature rupture of membranes (HP:0001788)4.62022543
3Neonatal short-limb short stature (HP:0008921)3.63005779
4Bladder diverticulum (HP:0000015)3.61770015
5Focal seizures (HP:0007359)3.56330825
6Vascular tortuosity (HP:0004948)3.48486081
7Atrophic scars (HP:0001075)3.27319332
8Arterial tortuosity (HP:0005116)3.24265988
9Myokymia (HP:0002411)3.22337016
10Focal motor seizures (HP:0011153)3.21139191
11Megalencephaly (HP:0001355)3.17651693
12Bowel diverticulosis (HP:0005222)3.16965644
13Epileptic encephalopathy (HP:0200134)3.12584954
14Action tremor (HP:0002345)3.11339216
15Aortic dissection (HP:0002647)3.03594109
16Obstructive sleep apnea (HP:0002870)2.98310920
17Abnormality of dentin (HP:0010299)2.96035892
18Turricephaly (HP:0000262)2.95477189
19Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.93343768
20Short 4th metacarpal (HP:0010044)2.93343768
21Soft skin (HP:0000977)2.86381822
22Genu recurvatum (HP:0002816)2.80029851
23Shallow orbits (HP:0000586)2.76681890
24Spinal rigidity (HP:0003306)2.73616097
25Aortic aneurysm (HP:0004942)2.72166352
26Ankle contracture (HP:0006466)2.71286554
27Pointed chin (HP:0000307)2.64640732
28Flat cornea (HP:0007720)2.63981334
29Visual hallucinations (HP:0002367)2.60001323
30Hemiplegia (HP:0002301)2.56979025
31Split foot (HP:0001839)2.56713912
32Wide anterior fontanel (HP:0000260)2.54912912
33Neoplasm of the heart (HP:0100544)2.54238974
34Progressive cerebellar ataxia (HP:0002073)2.53903246
35Annular pancreas (HP:0001734)2.47816891
36Type 1 muscle fiber predominance (HP:0003803)2.43693974
37Follicular hyperkeratosis (HP:0007502)2.39518561
38Wormian bones (HP:0002645)2.37163739
39Febrile seizures (HP:0002373)2.36848915
40Aqueductal stenosis (HP:0002410)2.36115390
41Increased variability in muscle fiber diameter (HP:0003557)2.36057734
42Vitreoretinal degeneration (HP:0000655)2.34427702
43Neurofibrillary tangles (HP:0002185)2.30912681
44Abnormality of the 4th metacarpal (HP:0010012)2.30795881
45Mild short stature (HP:0003502)2.29587142
46Trigonocephaly (HP:0000243)2.29447464
47Hypoplasia of the iris (HP:0007676)2.28282476
48Abnormality of the aortic arch (HP:0012303)2.27828099
49Mitral valve prolapse (HP:0001634)2.26379223
50Macroorchidism (HP:0000053)2.25187409
51Renovascular hypertension (HP:0100817)2.24052658
52Vertebral arch anomaly (HP:0008438)2.23610251
53Genetic anticipation (HP:0003743)2.17048032
54Hemiparesis (HP:0001269)2.16983363
55Slender build (HP:0001533)2.16703602
56Absence seizures (HP:0002121)2.16308525
57Hyperextensible skin (HP:0000974)2.15032604
58Morphological abnormality of the middle ear (HP:0008609)2.14969961
59Scotoma (HP:0000575)2.13420127
60Fragile skin (HP:0001030)2.12527403
61Prolonged QT interval (HP:0001657)2.10055090
62Open mouth (HP:0000194)2.08557370
63Central scotoma (HP:0000603)2.07763811
64Hypoventilation (HP:0002791)2.07322757
65Mitral regurgitation (HP:0001653)2.07186001
66Depression (HP:0000716)2.06434579
67Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.05954426
68Hyperacusis (HP:0010780)2.04427555
69Abnormality of the labia minora (HP:0012880)2.02899584
70Hepatoblastoma (HP:0002884)2.01409888
71Abnormality of the astrocytes (HP:0100707)2.00172630
72Astrocytoma (HP:0009592)2.00172630
73Obsessive-compulsive behavior (HP:0000722)2.00078826
74Insomnia (HP:0100785)1.96676136
75Limb-girdle muscle weakness (HP:0003325)1.96043827
76Coronal craniosynostosis (HP:0004440)1.95727510
77Megalocornea (HP:0000485)1.95617355
78Septo-optic dysplasia (HP:0100842)1.95575119
79Excessive salivation (HP:0003781)1.93720166
80Drooling (HP:0002307)1.93720166
81Congenital stationary night blindness (HP:0007642)1.93530252
82Biconcave vertebral bodies (HP:0004586)1.93195017
83Broad-based gait (HP:0002136)1.93120199
84Wrist flexion contracture (HP:0001239)1.93109222
85Truncus arteriosus (HP:0001660)1.92682080
86Supranuclear gaze palsy (HP:0000605)1.92678884
87Broad long bones (HP:0005622)1.92526099
88Abnormal eating behavior (HP:0100738)1.91210705
89Joint laxity (HP:0001388)1.90951192
90Dysdiadochokinesis (HP:0002075)1.90482290
91Polyphagia (HP:0002591)1.90041342
92Broad metatarsal (HP:0001783)1.89935431
93Elfin facies (HP:0004428)1.89842542
94Truncal ataxia (HP:0002078)1.88480880
95Mildly elevated creatine phosphokinase (HP:0008180)1.88480678
96Infantile muscular hypotonia (HP:0008947)1.87898219
97Cortical dysplasia (HP:0002539)1.87859052
98Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.87622969
99Cervical subluxation (HP:0003308)1.87339650
100Abnormal EKG (HP:0003115)1.86435581
101Dialeptic seizures (HP:0011146)1.85534773
102Mutism (HP:0002300)1.85486778
103Ulnar bowing (HP:0003031)1.85279007
104Glioma (HP:0009733)1.83845555
105Deviation of the hallux (HP:0010051)1.83213869
106Abnormality of skeletal muscle fiber size (HP:0012084)1.82691624
107Overgrowth (HP:0001548)1.82338101
108Limited hip movement (HP:0008800)1.82196925
109EEG with generalized epileptiform discharges (HP:0011198)1.82032756
110Dysmetria (HP:0001310)1.81966147
111Dilatation of the ascending aorta (HP:0005111)1.81884969
112Ankyloglossia (HP:0010296)1.81298192
113Cutaneous finger syndactyly (HP:0010554)1.80969103
114Hallux valgus (HP:0001822)1.80081764
115Postural instability (HP:0002172)1.79613610
116Epileptiform EEG discharges (HP:0011182)1.78623396
117Exotropia (HP:0000577)1.76879483
118Primary atrial arrhythmia (HP:0001692)1.76260413
119Intention tremor (HP:0002080)1.76259704
120Ventricular fibrillation (HP:0001663)1.75948669
121Arnold-Chiari malformation (HP:0002308)1.74829753
122Abnormality of the ischium (HP:0003174)1.74319183
123Long toe (HP:0010511)1.73378147
124Renal duplication (HP:0000075)1.72959964
125Stereotypic behavior (HP:0000733)1.72874012
126Sleep apnea (HP:0010535)1.72175140
127Aortic regurgitation (HP:0001659)1.71570085
128Buphthalmos (HP:0000557)1.71488829
129Amblyopia (HP:0000646)1.71093209
130Blue sclerae (HP:0000592)1.70620013
131Protruding ear (HP:0000411)1.70060769
132Growth hormone deficiency (HP:0000824)1.70045975
133Aplasia involving bones of the extremities (HP:0009825)1.69740210
134Aplasia involving bones of the upper limbs (HP:0009823)1.69740210
135Aplasia of the phalanges of the hand (HP:0009802)1.69740210
136Impaired smooth pursuit (HP:0007772)1.69584533
137Camptodactyly of toe (HP:0001836)1.68766710
138Natal tooth (HP:0000695)1.68756358
139Hip contracture (HP:0003273)1.68491457
140Cerebral inclusion bodies (HP:0100314)1.68417382
141Hypsarrhythmia (HP:0002521)1.68185098
142Overriding aorta (HP:0002623)1.67919184
143Thin ribs (HP:0000883)1.67400744
144Abnormal social behavior (HP:0012433)1.66601626
145Impaired social interactions (HP:0000735)1.66601626
146Peritonitis (HP:0002586)1.66365607
147Cutaneous syndactyly (HP:0012725)1.66075695
148Ectopia lentis (HP:0001083)1.65948356
149Cerebral aneurysm (HP:0004944)1.65102677
150Bronchomalacia (HP:0002780)1.64797579
151Abnormality of the diencephalon (HP:0010662)1.63870567
152Narrow nasal bridge (HP:0000446)1.63757383
153Generalized tonic-clonic seizures (HP:0002069)1.63596614
154Disproportionate tall stature (HP:0001519)1.63472057
155Anteriorly placed anus (HP:0001545)1.63133503
156Supraventricular tachycardia (HP:0004755)1.62658126
157Pulmonary artery stenosis (HP:0004415)1.62314626
158Abnormality of the parathyroid morphology (HP:0011766)1.61812264
159Torticollis (HP:0000473)1.61416107
160Pulmonic stenosis (HP:0001642)1.61289000
161Hammertoe (HP:0001765)1.61258114
162Supraventricular arrhythmia (HP:0005115)1.60836192
163Poor eye contact (HP:0000817)1.60829470
164Papilledema (HP:0001085)1.60686251
165Anophthalmia (HP:0000528)1.60354654
166Aneurysm (HP:0002617)1.60178576
167Lymphangioma (HP:0100764)1.59735373
168Absent frontal sinuses (HP:0002688)1.59474567
169Pheochromocytoma (HP:0002666)1.59069638
170Scanning speech (HP:0002168)1.58574067
171Atrial fibrillation (HP:0005110)1.58238242
172Broad phalanx (HP:0006009)1.57911991
173Abnormal pancreas size (HP:0012094)1.57035986
174Laryngomalacia (HP:0001601)1.56598698
175Back pain (HP:0003418)1.55475678

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK23.89376006
2KSR13.71260081
3SIK33.44837384
4MARK13.40642591
5EPHA42.84665743
6CASK2.76257172
7NTRK12.75470211
8NTRK32.60894883
9EPHB22.33509582
10MINK12.32487156
11PRKD32.19531718
12PAK61.93852974
13ERBB41.85190810
14TIE11.82955614
15FGFR21.80457580
16SIK11.77089765
17MAP3K41.70963612
18CAMKK11.64667763
19PHKG11.59187127
20PHKG21.59187127
21DAPK21.59114757
22TYRO31.55484788
23MAP3K91.54655791
24BCR1.53030340
25CAMK1G1.49762894
26LMTK21.42064342
27PDGFRB1.37818857
28KSR21.36083853
29EPHA31.34953409
30MAP3K101.32557252
31PDGFRA1.28998812
32CCNB11.28223047
33DMPK1.26108371
34DDR21.25757026
35TRIB31.23374054
36CDK51.20374955
37PAK21.16990408
38AKT31.15890204
39ERBB21.12022502
40ICK1.10308906
41UHMK11.09940135
42PAK31.08834672
43MYLK1.07458507
44LATS11.06364324
45MAP2K71.04716075
46LIMK11.03515734
47PKN11.03308313
48TESK11.02554555
49CAMK1D1.02011980
50MARK21.01891536
51STK381.00665369
52PKN20.99571467
53NEK10.99359266
54ERBB30.96338653
55SGK2230.96165422
56SGK4940.96165422
57RIPK10.95457760
58CDK180.92745030
59SGK20.91979070
60STK38L0.91254117
61MAPK130.90849303
62MOS0.87951421
63DYRK1A0.87592749
64CSNK1G20.86918516
65CAMK2G0.86135832
66PRKCG0.85363286
67NEK60.84891526
68PRPF4B0.84461986
69SGK30.84092486
70CDK120.82874054
71PINK10.82860663
72TNIK0.82334650
73MAP2K40.81184262
74PRKD20.79463655
75DYRK1B0.78298668
76EPHB10.78228639
77MET0.76336348
78CSNK1A1L0.75329933
79CDK150.74292128
80FGFR10.73829578
81ROCK10.73145564
82SIK20.72972475
83CAMKK20.72070312
84PRKCH0.71857450
85CAMK40.70204748
86RET0.69444788
87MAPK70.69195961
88MAP3K60.69111404
89CDK140.67822890
90CLK10.66565901
91INSRR0.66191608
92TNK20.63780515
93LATS20.63561305
94MTOR0.61132751
95NEK90.60723335
96CDK11A0.60173722
97BRD40.59539647
98KDR0.59518096
99PLK20.59486864
100ROCK20.59346803
101TGFBR20.58549902
102DAPK10.58506411
103PRKCE0.57520183
104PNCK0.56496530
105CAMK2D0.56368113
106CAMK2A0.56360015
107WNK10.56194152
108ALK0.54762279
109MAP3K70.54578655
110SGK10.54147013
111PTK60.53594893
112FER0.52811329
113RPS6KA20.51489689
114CSNK1G30.51047010
115CSNK1G10.50921432
116PRKCZ0.50523565
117CDC42BPA0.49889522
118CAMK10.49717260
119MAPK100.48635984
120RPS6KA30.48622991
121PTK20.48150563
122TTN0.48034021
123PRKAA10.47942279
124PRKD10.47625622
125SRC0.46637723
126TAOK20.45998396
127FYN0.44443973
128DYRK20.44350675
129WNK30.43834995
130FES0.43496503
131FGFR40.41206701
132CAMK2B0.40832747
133MAPK90.40441611
134STK110.38976792

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.90417367
2ECM-receptor interaction_Homo sapiens_hsa045122.72553120
3GABAergic synapse_Homo sapiens_hsa047272.29564885
4Circadian entrainment_Homo sapiens_hsa047132.20750692
5Morphine addiction_Homo sapiens_hsa050322.06160727
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.03547589
7Synaptic vesicle cycle_Homo sapiens_hsa047211.98037250
8Glutamatergic synapse_Homo sapiens_hsa047241.94389716
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.84212390
10Olfactory transduction_Homo sapiens_hsa047401.83299968
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.78969702
12Axon guidance_Homo sapiens_hsa043601.78827638
13Insulin secretion_Homo sapiens_hsa049111.73145013
14Cholinergic synapse_Homo sapiens_hsa047251.71583759
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69418318
16Long-term potentiation_Homo sapiens_hsa047201.69111065
17Salivary secretion_Homo sapiens_hsa049701.68885420
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.65677086
19Dopaminergic synapse_Homo sapiens_hsa047281.60694048
20Protein digestion and absorption_Homo sapiens_hsa049741.60181506
21Dilated cardiomyopathy_Homo sapiens_hsa054141.50450200
22Oxytocin signaling pathway_Homo sapiens_hsa049211.50217068
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49875667
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47614950
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.41057736
26Amphetamine addiction_Homo sapiens_hsa050311.38979241
27Type II diabetes mellitus_Homo sapiens_hsa049301.38969602
28Glioma_Homo sapiens_hsa052141.33797970
29Gap junction_Homo sapiens_hsa045401.32998157
30Cocaine addiction_Homo sapiens_hsa050301.32098451
31Renin secretion_Homo sapiens_hsa049241.31835378
32Gastric acid secretion_Homo sapiens_hsa049711.28987727
33ErbB signaling pathway_Homo sapiens_hsa040121.26357295
34Amoebiasis_Homo sapiens_hsa051461.24691714
35Basal cell carcinoma_Homo sapiens_hsa052171.23768308
36Calcium signaling pathway_Homo sapiens_hsa040201.20604137
37Thyroid hormone signaling pathway_Homo sapiens_hsa049191.20460970
38Estrogen signaling pathway_Homo sapiens_hsa049151.19103312
39Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.18528006
40Long-term depression_Homo sapiens_hsa047301.17745897
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16736341
42Endometrial cancer_Homo sapiens_hsa052131.14348071
43Taste transduction_Homo sapiens_hsa047421.13841164
44GnRH signaling pathway_Homo sapiens_hsa049121.13527797
45cAMP signaling pathway_Homo sapiens_hsa040241.13427878
46Melanogenesis_Homo sapiens_hsa049161.13342394
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11989833
48Prion diseases_Homo sapiens_hsa050201.11669504
49Regulation of actin cytoskeleton_Homo sapiens_hsa048101.07145707
50Serotonergic synapse_Homo sapiens_hsa047261.07045951
51PI3K-Akt signaling pathway_Homo sapiens_hsa041511.04210997
52Tight junction_Homo sapiens_hsa045301.03614708
53Dorso-ventral axis formation_Homo sapiens_hsa043201.03528107
54Phospholipase D signaling pathway_Homo sapiens_hsa040721.03462353
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03177753
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02434996
57Neurotrophin signaling pathway_Homo sapiens_hsa047221.00008223
58Hedgehog signaling pathway_Homo sapiens_hsa043400.99814758
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99700141
60Renal cell carcinoma_Homo sapiens_hsa052110.99197997
61Melanoma_Homo sapiens_hsa052180.98813233
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98027317
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96984844
64Colorectal cancer_Homo sapiens_hsa052100.96712116
65Hippo signaling pathway_Homo sapiens_hsa043900.95523809
66Non-small cell lung cancer_Homo sapiens_hsa052230.93871253
67mTOR signaling pathway_Homo sapiens_hsa041500.92735002
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88960302
69Wnt signaling pathway_Homo sapiens_hsa043100.88257757
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88003664
71Circadian rhythm_Homo sapiens_hsa047100.87511181
72Choline metabolism in cancer_Homo sapiens_hsa052310.87320156
73Pathways in cancer_Homo sapiens_hsa052000.84228876
74Vibrio cholerae infection_Homo sapiens_hsa051100.84100695
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82704259
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78710935
77Phototransduction_Homo sapiens_hsa047440.78283846
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78278875
79Proteoglycans in cancer_Homo sapiens_hsa052050.77264261
80VEGF signaling pathway_Homo sapiens_hsa043700.75898911
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74808162
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74633936
83Focal adhesion_Homo sapiens_hsa045100.74386282
84Rap1 signaling pathway_Homo sapiens_hsa040150.73669429
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73487973
86Small cell lung cancer_Homo sapiens_hsa052220.72305579
87MAPK signaling pathway_Homo sapiens_hsa040100.71314253
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71310804
89Chronic myeloid leukemia_Homo sapiens_hsa052200.70545565
90TGF-beta signaling pathway_Homo sapiens_hsa043500.69516334
91Notch signaling pathway_Homo sapiens_hsa043300.68745790
92Nitrogen metabolism_Homo sapiens_hsa009100.67394577
93Oocyte meiosis_Homo sapiens_hsa041140.67383828
94Insulin signaling pathway_Homo sapiens_hsa049100.65743928
95Cardiac muscle contraction_Homo sapiens_hsa042600.65363068
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64425908
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63243247
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.63030000
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.62137830
100Lysine degradation_Homo sapiens_hsa003100.61588359
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.60442661
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58790186
103Bladder cancer_Homo sapiens_hsa052190.57919921
104Thyroid hormone synthesis_Homo sapiens_hsa049180.57618124
105Ras signaling pathway_Homo sapiens_hsa040140.56613778
106Pancreatic secretion_Homo sapiens_hsa049720.56447606
107Glucagon signaling pathway_Homo sapiens_hsa049220.56394415
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.56018579
109Pancreatic cancer_Homo sapiens_hsa052120.55743145
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55338446
111Inositol phosphate metabolism_Homo sapiens_hsa005620.53312626
112AMPK signaling pathway_Homo sapiens_hsa041520.53008075
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52491725
114MicroRNAs in cancer_Homo sapiens_hsa052060.51357620
115Endocytosis_Homo sapiens_hsa041440.48959540
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48871463
117Bile secretion_Homo sapiens_hsa049760.47894306
118Adherens junction_Homo sapiens_hsa045200.47873801
119Alcoholism_Homo sapiens_hsa050340.47766558
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47310084

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