ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.87522876
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.88332723
3	L-fucose catabolic process (GO:0042355)	4.45525211
4	fucose catabolic process (GO:0019317)	4.45525211
5	L-fucose metabolic process (GO:0042354)	4.45525211
6	indolalkylamine metabolic process (GO:0006586)	3.88183888
7	indole-containing compound catabolic process (GO:0042436)	3.69045110
8	indolalkylamine catabolic process (GO:0046218)	3.69045110
9	tryptophan catabolic process (GO:0006569)	3.69045110
10	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.64802473
11	pyrimidine nucleobase catabolic process (GO:0006208)	3.55598156
12	kynurenine metabolic process (GO:0070189)	3.55129294
13	tryptophan metabolic process (GO:0006568)	3.47478485
14	water-soluble vitamin biosynthetic process (GO:0042364)	3.47332812
15	DNA deamination (GO:0045006)	3.46339924
16	epithelial cilium movement (GO:0003351)	3.44026946
17	primary amino compound metabolic process (GO:1901160)	3.41106616
18	protein K11-linked deubiquitination (GO:0035871)	3.40298416
19	kidney morphogenesis (GO:0060993)	3.34074799
20	protein polyglutamylation (GO:0018095)	3.22584387
21	positive regulation of prostaglandin secretion (GO:0032308)	3.19241024
22	regulation of hexokinase activity (GO:1903299)	3.18462860
23	regulation of glucokinase activity (GO:0033131)	3.18462860
24	indole-containing compound metabolic process (GO:0042430)	3.17667093
25	serotonin metabolic process (GO:0042428)	3.15026451
26	positive regulation of fatty acid transport (GO:2000193)	3.12559668
27	regulation of action potential (GO:0098900)	3.11555511
28	reflex (GO:0060004)	3.10720529
29	nucleobase catabolic process (GO:0046113)	3.10347608
30	cilium or flagellum-dependent cell motility (GO:0001539)	3.08182045
31	nonmotile primary cilium assembly (GO:0035058)	3.07434845
32	somite development (GO:0061053)	3.05288459
33	rRNA catabolic process (GO:0016075)	3.05084618
34	axoneme assembly (GO:0035082)	3.03623620
35	response to pheromone (GO:0019236)	3.01548056
36	synaptic transmission, cholinergic (GO:0007271)	2.95623910
37	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.94089031
38	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.92298731
39	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.92104745
40	cellular ketone body metabolic process (GO:0046950)	2.89053654
41	protein complex biogenesis (GO:0070271)	2.88460416
42	cellular biogenic amine catabolic process (GO:0042402)	2.85029936
43	amine catabolic process (GO:0009310)	2.85029936
44	protein localization to cilium (GO:0061512)	2.84254275
45	neuronal action potential (GO:0019228)	2.84125787
46	negative regulation of telomere maintenance (GO:0032205)	2.82817804
47	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.81621399
48	NADH dehydrogenase complex assembly (GO:0010257)	2.81621399
49	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.81621399
50	positive regulation of icosanoid secretion (GO:0032305)	2.81241984
51	cornea development in camera-type eye (GO:0061303)	2.80376015
52	photoreceptor cell development (GO:0042461)	2.77997964
53	hindbrain development (GO:0030902)	2.77437018
54	cilium movement (GO:0003341)	2.76204413
55	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.74364685
56	protein-cofactor linkage (GO:0018065)	2.73931805
57	postsynaptic membrane organization (GO:0001941)	2.73311237
58	respiratory chain complex IV assembly (GO:0008535)	2.72017392
59	cilium organization (GO:0044782)	2.71741921
60	regulation of cilium movement (GO:0003352)	2.69449092
61	cilium assembly (GO:0042384)	2.69203262
62	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.68899394
63	cAMP catabolic process (GO:0006198)	2.68425079
64	cilium morphogenesis (GO:0060271)	2.67558218
65	nephron epithelium morphogenesis (GO:0072088)	2.66239342
66	nephron tubule morphogenesis (GO:0072078)	2.66239342
67	DNA double-strand break processing (GO:0000729)	2.65581231
68	base-excision repair, AP site formation (GO:0006285)	2.65567101
69	ubiquinone metabolic process (GO:0006743)	2.65059890
70	ubiquinone biosynthetic process (GO:0006744)	2.63696028
71	atrial cardiac muscle cell action potential (GO:0086014)	2.60475781
72	gamma-aminobutyric acid transport (GO:0015812)	2.60211304
73	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.59322271
74	axonemal dynein complex assembly (GO:0070286)	2.58916610
75	mitochondrial respiratory chain complex assembly (GO:0033108)	2.58535344
76	detection of light stimulus involved in visual perception (GO:0050908)	2.56518109
77	detection of light stimulus involved in sensory perception (GO:0050962)	2.56518109
78	piRNA metabolic process (GO:0034587)	2.56462519
79	alkaloid metabolic process (GO:0009820)	2.54682108
80	head development (GO:0060322)	2.53098457
81	ketone body metabolic process (GO:1902224)	2.52526259
82	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.52365174
83	fucosylation (GO:0036065)	2.50350977
84	limb bud formation (GO:0060174)	2.49038828
85	auditory behavior (GO:0031223)	2.48383009
86	intraciliary transport (GO:0042073)	2.48079204
87	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.47579486
88	benzene-containing compound metabolic process (GO:0042537)	2.46410879
89	regulation of microtubule-based movement (GO:0060632)	2.45309992
90	anterograde synaptic vesicle transport (GO:0048490)	2.44723063
91	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.44309507
92	neural tube formation (GO:0001841)	2.43374534
93	sulfation (GO:0051923)	2.43328136
94	regulation of prostaglandin secretion (GO:0032306)	2.43238325
95	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.43210516
96	mannosylation (GO:0097502)	2.42935417
97	platelet dense granule organization (GO:0060155)	2.41423447
98	positive regulation of organic acid transport (GO:0032892)	2.40899203
99	negative regulation of astrocyte differentiation (GO:0048712)	2.39611882
100	eye photoreceptor cell development (GO:0042462)	2.39431451

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.03072618
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.71599314
3	VDR_22108803_ChIP-Seq_LS180_Human	3.11951979
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.99761381
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.75250718
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.64695381
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.55893790
8	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.22347187
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.19547672
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.08475780
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.04592937
12	FUS_26573619_Chip-Seq_HEK293_Human	2.00593569
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.00527056
14	EWS_26573619_Chip-Seq_HEK293_Human	1.98445997
15	TAF15_26573619_Chip-Seq_HEK293_Human	1.97420710
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.90457233
17	IGF1R_20145208_ChIP-Seq_DFB_Human	1.89645579
18	P300_19829295_ChIP-Seq_ESCs_Human	1.87597679
19	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.74527952
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.71590362
21	REST_21632747_ChIP-Seq_MESCs_Mouse	1.67526730
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.67385531
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.64431862
24	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.61288773
25	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.60400995
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.59692492
27	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.57820983
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.55345232
29	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.53525957
30	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.50311589
31	STAT3_23295773_ChIP-Seq_U87_Human	1.49783689
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.49395142
33	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.47964405
34	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.47772903
35	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.47083374
36	AR_25329375_ChIP-Seq_VCAP_Human	1.47000596
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.46909776
38	RNF2_27304074_Chip-Seq_NSC_Mouse	1.45165134
39	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.44498579
40	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44498579
41	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.42560981
42	CBP_20019798_ChIP-Seq_JUKART_Human	1.42048435
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42048435
44	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.40312440
45	TCF4_23295773_ChIP-Seq_U87_Human	1.39074686
46	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.38435328
47	BCAT_22108803_ChIP-Seq_LS180_Human	1.37596466
48	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.36291342
49	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.36182279
50	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.34290223
51	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.33431242
52	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.33164713
53	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.32574663
54	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.31974759
55	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.30261155
56	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.28973009
57	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.28931248
58	MYC_18940864_ChIP-ChIP_HL60_Human	1.28380455
59	RUNX2_22187159_ChIP-Seq_PCA_Human	1.28137262
60	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.27429718
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.26027213
62	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.26027213
63	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.23955410
64	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.23337509
65	SOX2_19829295_ChIP-Seq_ESCs_Human	1.22038840
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.22038840
67	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.21394327
68	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.20767386
69	IRF1_19129219_ChIP-ChIP_H3396_Human	1.20583253
70	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.19154811
71	TCF4_22108803_ChIP-Seq_LS180_Human	1.19132525
72	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.18598295
73	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.18389978
74	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.14536169
75	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.13771731
76	NCOR_22424771_ChIP-Seq_293T_Human	1.11924217
77	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.11684342
78	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.11345000
79	TP53_16413492_ChIP-PET_HCT116_Human	1.11304285
80	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.10192023
81	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.10043078
82	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.09946349
83	HOXB7_26014856_ChIP-Seq_BT474_Human	1.09408509
84	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.09358530
85	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.09354673
86	DROSHA_22980978_ChIP-Seq_HELA_Human	1.05820837
87	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.05617077
88	AR_21572438_ChIP-Seq_LNCaP_Human	1.04650873
89	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.04517242
90	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.04385888
91	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.03726905
92	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.02402063
93	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01821562
94	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01572281
95	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.01484849
96	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.01199088
97	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.00596279
98	P53_22387025_ChIP-Seq_ESCs_Mouse	0.99140641
99	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.99104900
100	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.98987160

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.38416426
2	MP0000569_abnormal_digit_pigmentation	2.79869286
3	MP0001968_abnormal_touch/_nociception	2.60045839
4	MP0008877_abnormal_DNA_methylation	2.59637118
5	MP0006292_abnormal_olfactory_placode	2.32135931
6	MP0005551_abnormal_eye_electrophysiolog	2.27167056
7	MP0003646_muscle_fatigue	2.22177868
8	MP0002638_abnormal_pupillary_reflex	2.06862889
9	MP0003880_abnormal_central_pattern	2.06055770
10	MP0004133_heterotaxia	2.03850161
11	MP0006072_abnormal_retinal_apoptosis	2.01551564
12	MP0009046_muscle_twitch	1.96080116
13	MP0009745_abnormal_behavioral_response	1.94936006
14	MP0005645_abnormal_hypothalamus_physiol	1.94603230
15	MP0002837_dystrophic_cardiac_calcinosis	1.91498661
16	MP0001986_abnormal_taste_sensitivity	1.87486766
17	MP0006276_abnormal_autonomic_nervous	1.84660832
18	MP0003195_calcinosis	1.83567617
19	MP0004885_abnormal_endolymph	1.82483530
20	MP0004142_abnormal_muscle_tone	1.79342888
21	MP0000631_abnormal_neuroendocrine_gland	1.78285653
22	MP0005253_abnormal_eye_physiology	1.77916098
23	MP0003787_abnormal_imprinting	1.75161627
24	MP0002938_white_spotting	1.74636173
25	MP0005646_abnormal_pituitary_gland	1.72840176
26	MP0008872_abnormal_physiological_respon	1.66975784
27	MP0002736_abnormal_nociception_after	1.65983916
28	MP0002557_abnormal_social/conspecific_i	1.60161813
29	MP0001501_abnormal_sleep_pattern	1.56604891
30	MP0005377_hearing/vestibular/ear_phenot	1.56481979
31	MP0003878_abnormal_ear_physiology	1.56481979
32	MP0002735_abnormal_chemical_nociception	1.56411766
33	MP0001486_abnormal_startle_reflex	1.55845028
34	MP0002272_abnormal_nervous_system	1.55078081
35	MP0004147_increased_porphyrin_level	1.54246607
36	MP0001485_abnormal_pinna_reflex	1.54068055
37	MP0001905_abnormal_dopamine_level	1.53782961
38	MP0001529_abnormal_vocalization	1.52843567
39	MP0002876_abnormal_thyroid_physiology	1.48951122
40	MP0008875_abnormal_xenobiotic_pharmacok	1.48726321
41	MP0001984_abnormal_olfaction	1.48724741
42	MP0000427_abnormal_hair_cycle	1.48407924
43	MP0003122_maternal_imprinting	1.44359639
44	MP0008995_early_reproductive_senescence	1.43420923
45	MP0002572_abnormal_emotion/affect_behav	1.43074678
46	MP0002064_seizures	1.41758601
47	MP0000372_irregular_coat_pigmentation	1.39711779
48	MP0005386_behavior/neurological_phenoty	1.39661567
49	MP0004924_abnormal_behavior	1.39661567
50	MP0002909_abnormal_adrenal_gland	1.39414779
51	MP0000778_abnormal_nervous_system	1.36598941
52	MP0002733_abnormal_thermal_nociception	1.34898887
53	MP0003121_genomic_imprinting	1.34680751
54	MP0002653_abnormal_ependyma_morphology	1.34631349
55	MP0003136_yellow_coat_color	1.33108329
56	MP0003011_delayed_dark_adaptation	1.33082678
57	MP0004742_abnormal_vestibular_system	1.31809923
58	MP0004145_abnormal_muscle_electrophysio	1.31619089
59	MP0000383_abnormal_hair_follicle	1.31017636
60	MP0005084_abnormal_gallbladder_morpholo	1.30759925
61	MP0003635_abnormal_synaptic_transmissio	1.29758964
62	MP0002067_abnormal_sensory_capabilities	1.28474064
63	MP0001970_abnormal_pain_threshold	1.26737049
64	MP0002063_abnormal_learning/memory/cond	1.26669322
65	MP0005423_abnormal_somatic_nervous	1.25105516
66	MP0004043_abnormal_pH_regulation	1.24353955
67	MP0002163_abnormal_gland_morphology	1.21122575
68	MP0002822_catalepsy	1.12017196
69	MP0005379_endocrine/exocrine_gland_phen	1.10811066
70	MP0002160_abnormal_reproductive_system	1.09784069
71	MP0005195_abnormal_posterior_eye	1.09407042
72	MP0000026_abnormal_inner_ear	1.08663151
73	MP0003937_abnormal_limbs/digits/tail_de	1.06738413
74	MP0010386_abnormal_urinary_bladder	1.03389805
75	MP0002234_abnormal_pharynx_morphology	1.03220622
76	MP0002734_abnormal_mechanical_nocicepti	1.03060654
77	MP0001502_abnormal_circadian_rhythm	1.01588833
78	MP0008775_abnormal_heart_ventricle	0.99819591
79	MP0004215_abnormal_myocardial_fiber	0.99006831
80	MP0005389_reproductive_system_phenotype	0.97997897
81	MP0003137_abnormal_impulse_conducting	0.97142017
82	MP0002752_abnormal_somatic_nervous	0.94707130
83	MP0001963_abnormal_hearing_physiology	0.92774428
84	MP0000049_abnormal_middle_ear	0.90913697
85	MP0003890_abnormal_embryonic-extraembry	0.90263873
86	MP0002184_abnormal_innervation	0.89619054
87	MP0003119_abnormal_digestive_system	0.89606445
88	MP0002751_abnormal_autonomic_nervous	0.88836315
89	MP0001293_anophthalmia	0.88716633
90	MP0008789_abnormal_olfactory_epithelium	0.88497363
91	MP0002928_abnormal_bile_duct	0.88017464
92	MP0001440_abnormal_grooming_behavior	0.86348289
93	MP0004859_abnormal_synaptic_plasticity	0.85398734
94	MP0005394_taste/olfaction_phenotype	0.84996264
95	MP0005499_abnormal_olfactory_system	0.84996264
96	MP0002229_neurodegeneration	0.83281280
97	MP0003283_abnormal_digestive_organ	0.81860684
98	MP0002095_abnormal_skin_pigmentation	0.80036546
99	MP0003938_abnormal_ear_development	0.79607586
100	MP0002277_abnormal_respiratory_mucosa	0.79433799

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.43317596
2	Pancreatic fibrosis (HP:0100732)	4.25632841
3	Molar tooth sign on MRI (HP:0002419)	4.23094058
4	Abnormality of midbrain morphology (HP:0002418)	4.23094058
5	True hermaphroditism (HP:0010459)	3.77466854
6	Congenital stationary night blindness (HP:0007642)	3.64048868
7	Nephronophthisis (HP:0000090)	3.63235379
8	Pendular nystagmus (HP:0012043)	3.30309846
9	Chronic hepatic failure (HP:0100626)	3.26109159
10	Abnormality of the renal medulla (HP:0100957)	3.17403737
11	Type II lissencephaly (HP:0007260)	3.13266658
12	Hyperventilation (HP:0002883)	3.11344042
13	Medial flaring of the eyebrow (HP:0010747)	3.03015556
14	Limb dystonia (HP:0002451)	2.95584478
15	Abnormality of the renal cortex (HP:0011035)	2.87702064
16	Abnormal respiratory motile cilium morphology (HP:0005938)	2.75117120
17	Abnormal respiratory epithelium morphology (HP:0012253)	2.75117120
18	3-Methylglutaconic aciduria (HP:0003535)	2.73143091
19	Hypothermia (HP:0002045)	2.73138902
20	Cystic liver disease (HP:0006706)	2.72210792
21	Gait imbalance (HP:0002141)	2.68513749
22	Decreased circulating renin level (HP:0003351)	2.58972095
23	Abolished electroretinogram (ERG) (HP:0000550)	2.58942862
24	Bile duct proliferation (HP:0001408)	2.58884359
25	Abnormal biliary tract physiology (HP:0012439)	2.58884359
26	Congenital primary aphakia (HP:0007707)	2.51410825
27	Increased corneal curvature (HP:0100692)	2.50904061
28	Keratoconus (HP:0000563)	2.50904061
29	Protruding tongue (HP:0010808)	2.50517666
30	Tubular atrophy (HP:0000092)	2.36938366
31	Polydipsia (HP:0001959)	2.35439252
32	Abnormal drinking behavior (HP:0030082)	2.35439252
33	Broad-based gait (HP:0002136)	2.33280871
34	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.31771849
35	Inability to walk (HP:0002540)	2.31538267
36	Nephrogenic diabetes insipidus (HP:0009806)	2.30593879
37	Chorioretinal atrophy (HP:0000533)	2.28597511
38	Sclerocornea (HP:0000647)	2.27826662
39	Genital tract atresia (HP:0001827)	2.27292700
40	Lissencephaly (HP:0001339)	2.27137972
41	Cerebellar dysplasia (HP:0007033)	2.19628883
42	Vaginal atresia (HP:0000148)	2.19187897
43	Optic nerve hypoplasia (HP:0000609)	2.15759268
44	Birth length less than 3rd percentile (HP:0003561)	2.14588498
45	Aplasia/Hypoplasia of the patella (HP:0006498)	2.10912534
46	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.10788617
47	Febrile seizures (HP:0002373)	2.09902682
48	Attenuation of retinal blood vessels (HP:0007843)	2.08719861
49	Congenital hepatic fibrosis (HP:0002612)	2.07887931
50	Concave nail (HP:0001598)	2.07256361
51	Abnormal rod and cone electroretinograms (HP:0008323)	2.04806602
52	Renal cortical cysts (HP:0000803)	2.04789395
53	Pachygyria (HP:0001302)	2.03967300
54	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.02124561
55	Abnormality of alanine metabolism (HP:0010916)	2.02124561
56	Hyperalaninemia (HP:0003348)	2.02124561
57	Patellar aplasia (HP:0006443)	2.02042508
58	Postaxial foot polydactyly (HP:0001830)	2.01279009
59	Anencephaly (HP:0002323)	2.00457975
60	Furrowed tongue (HP:0000221)	1.99826161
61	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.97029418
62	Gaze-evoked nystagmus (HP:0000640)	1.96416689
63	Polyphagia (HP:0002591)	1.96161989
64	Supernumerary spleens (HP:0009799)	1.95214083
65	Acute necrotizing encephalopathy (HP:0006965)	1.94921797
66	Polyuria (HP:0000103)	1.94567470
67	Drooling (HP:0002307)	1.94272963
68	Retinal dysplasia (HP:0007973)	1.92922297
69	Absent/shortened dynein arms (HP:0200106)	1.92852440
70	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.92852440
71	Progressive inability to walk (HP:0002505)	1.92688210
72	Progressive macrocephaly (HP:0004481)	1.92579963
73	Male pseudohermaphroditism (HP:0000037)	1.91911137
74	Mitochondrial inheritance (HP:0001427)	1.89839751
75	Abnormal ciliary motility (HP:0012262)	1.88890714
76	Postaxial hand polydactyly (HP:0001162)	1.88686114
77	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.88118860
78	Hemiparesis (HP:0001269)	1.85887810
79	Abnormality of the labia minora (HP:0012880)	1.85837907
80	Agitation (HP:0000713)	1.85814694
81	Decreased central vision (HP:0007663)	1.84216961
82	Abnormality of the renal collecting system (HP:0004742)	1.83446939
83	Genetic anticipation (HP:0003743)	1.82413229
84	Fair hair (HP:0002286)	1.81117680
85	Poor coordination (HP:0002370)	1.75925048
86	Stomach cancer (HP:0012126)	1.74767622
87	Short tibia (HP:0005736)	1.74499018
88	Hypoplasia of the pons (HP:0012110)	1.73547378
89	Increased CSF lactate (HP:0002490)	1.73195164
90	Progressive cerebellar ataxia (HP:0002073)	1.72319172
91	Excessive salivation (HP:0003781)	1.71713941
92	Asplenia (HP:0001746)	1.71162496
93	Severe muscular hypotonia (HP:0006829)	1.70670264
94	Abnormality of the pons (HP:0007361)	1.69899693
95	Narrow forehead (HP:0000341)	1.68218057
96	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.67643872
97	Duplicated collecting system (HP:0000081)	1.66478443
98	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.66365480
99	Septo-optic dysplasia (HP:0100842)	1.65904177
100	Colon cancer (HP:0003003)	1.64582234

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.10021391
2	ADRBK2	3.63456736
3	GRK1	2.94871301
4	CASK	2.84115596
5	MAP3K4	2.72414408
6	WNK3	2.67966871
7	BMPR1B	2.61408752
8	TAOK3	2.41767302
9	MAPK13	2.35188126
10	TLK1	2.28765425
11	MAP4K2	2.24896329
12	MARK1	2.19421767
13	ZAK	2.17035575
14	WNK4	2.12160839
15	PINK1	2.00445418
16	DAPK2	1.90073134
17	INSRR	1.87745652
18	NTRK3	1.84234932
19	MAP2K7	1.75667505
20	ACVR1B	1.68279939
21	PNCK	1.66373617
22	NUAK1	1.65206561
23	STK39	1.47035326
24	TNIK	1.43547161
25	MKNK2	1.35786131
26	OXSR1	1.35231296
27	DYRK2	1.34397805
28	TIE1	1.26616655
29	PAK3	1.25727295
30	NTRK2	1.24317125
31	PHKG1	1.17924336
32	PHKG2	1.17924336
33	BCKDK	1.08884261
34	PRKCG	1.07858968
35	ADRBK1	1.06730295
36	FGFR2	1.06442760
37	TXK	1.05441574
38	MUSK	1.04010555
39	PRKCE	0.97813981
40	MAPKAPK5	0.93431449
41	MAP2K4	0.91886151
42	AKT3	0.89757124
43	PLK2	0.84166853
44	CAMKK2	0.79702080
45	TGFBR1	0.76980858
46	OBSCN	0.74606270
47	PIK3CA	0.73039645
48	BCR	0.72503257
49	VRK1	0.70347506
50	TRIM28	0.69125004
51	CSNK1G2	0.67991196
52	CSNK1G1	0.67792515
53	CAMK2A	0.67209337
54	STK38L	0.67087769
55	STK16	0.63939571
56	MKNK1	0.63610669
57	PLK4	0.59674538
58	PTK2B	0.59548163
59	CAMK1	0.59534546
60	PKN1	0.59412337
61	MAPKAPK3	0.58944768
62	MAPK15	0.58927257
63	PRKACA	0.56846754
64	PRKAA1	0.56090153
65	RPS6KA5	0.54983134
66	CAMK1D	0.53994032
67	CSNK1G3	0.53514241
68	PRKCQ	0.52421852
69	PRKAA2	0.51580774
70	ERBB2	0.50094383
71	EPHA3	0.49035586
72	TNK2	0.48749599
73	PRKCI	0.48606253
74	BRSK2	0.48041510
75	CSNK1A1	0.47235088
76	CAMK4	0.45350823
77	WEE1	0.44340216
78	EPHA4	0.42775499
79	MAP2K6	0.42252838
80	DYRK1A	0.41147816
81	TEC	0.40883236
82	CSNK1A1L	0.40515561
83	SGK2	0.38276956
84	CAMK1G	0.37648375
85	NLK	0.36747394
86	ERBB3	0.35880834
87	DYRK3	0.35368132
88	CAMK2D	0.35244180
89	PRKD2	0.34924367
90	PRKG1	0.34796515
91	PRKCA	0.34152965
92	STK11	0.33384046
93	CAMK2B	0.32145309
94	IKBKB	0.31183388
95	SGK494	0.31142245
96	SGK223	0.31142245
97	CDK5	0.29560580
98	PRKACB	0.29536733
99	FER	0.29532558
100	NME1	0.28302490

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Linoleic acid metabolism_Homo sapiens_hsa00591	3.01391814
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.99436575
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.94713835
4	Nicotine addiction_Homo sapiens_hsa05033	2.87620431
5	Phototransduction_Homo sapiens_hsa04744	2.76733947
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.44215120
7	Butanoate metabolism_Homo sapiens_hsa00650	2.38050877
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.31237129
9	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.20328505
10	Nitrogen metabolism_Homo sapiens_hsa00910	2.13758374
11	Ether lipid metabolism_Homo sapiens_hsa00565	2.08747153
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.98317657
13	Selenocompound metabolism_Homo sapiens_hsa00450	1.98188731
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.96932194
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.95245768
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.91212851
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.89589495
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.82004181
19	Parkinsons disease_Homo sapiens_hsa05012	1.79461823
20	Taste transduction_Homo sapiens_hsa04742	1.62729458
21	Morphine addiction_Homo sapiens_hsa05032	1.62723516
22	Homologous recombination_Homo sapiens_hsa03440	1.57881611
23	Basal transcription factors_Homo sapiens_hsa03022	1.54419319
24	Protein export_Homo sapiens_hsa03060	1.53185533
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.48084966
26	Cardiac muscle contraction_Homo sapiens_hsa04260	1.48029809
27	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.44483321
28	GABAergic synapse_Homo sapiens_hsa04727	1.36570908
29	RNA polymerase_Homo sapiens_hsa03020	1.34207165
30	Caffeine metabolism_Homo sapiens_hsa00232	1.31025333
31	Olfactory transduction_Homo sapiens_hsa04740	1.26338757
32	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.24517024
33	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.22412181
34	Regulation of autophagy_Homo sapiens_hsa04140	1.22364201
35	Serotonergic synapse_Homo sapiens_hsa04726	1.20713253
36	Circadian entrainment_Homo sapiens_hsa04713	1.19207215
37	Glutamatergic synapse_Homo sapiens_hsa04724	1.15617027
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.12038351
39	Fat digestion and absorption_Homo sapiens_hsa04975	1.11118778
40	Insulin secretion_Homo sapiens_hsa04911	1.09975627
41	Huntingtons disease_Homo sapiens_hsa05016	1.09448234
42	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.07520810
43	Alzheimers disease_Homo sapiens_hsa05010	1.06763204
44	Peroxisome_Homo sapiens_hsa04146	1.05673379
45	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.05552634
46	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.04558677
47	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.96246382
48	ABC transporters_Homo sapiens_hsa02010	0.94869662
49	Cocaine addiction_Homo sapiens_hsa05030	0.94075534
50	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.94036975
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.93567217
52	Mineral absorption_Homo sapiens_hsa04978	0.93056179
53	Retinol metabolism_Homo sapiens_hsa00830	0.90330333
54	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.89654674
55	Propanoate metabolism_Homo sapiens_hsa00640	0.89216674
56	Histidine metabolism_Homo sapiens_hsa00340	0.88440084
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.86504234
58	Dopaminergic synapse_Homo sapiens_hsa04728	0.84916738
59	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.81476227
60	Collecting duct acid secretion_Homo sapiens_hsa04966	0.79932423
61	RNA degradation_Homo sapiens_hsa03018	0.78447525
62	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.78005758
63	Steroid biosynthesis_Homo sapiens_hsa00100	0.74359012
64	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.73707970
65	Amphetamine addiction_Homo sapiens_hsa05031	0.71558202
66	Glycerolipid metabolism_Homo sapiens_hsa00561	0.68842406
67	Calcium signaling pathway_Homo sapiens_hsa04020	0.66090979
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.64217106
69	Cholinergic synapse_Homo sapiens_hsa04725	0.63851050
70	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.58540465
71	Salivary secretion_Homo sapiens_hsa04970	0.57887314
72	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.56329480
73	beta-Alanine metabolism_Homo sapiens_hsa00410	0.55297794
74	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.54739849
75	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.53785417
76	Metabolic pathways_Homo sapiens_hsa01100	0.53533278
77	Alcoholism_Homo sapiens_hsa05034	0.53413131
78	Sulfur metabolism_Homo sapiens_hsa00920	0.51904336
79	Axon guidance_Homo sapiens_hsa04360	0.50564520
80	cAMP signaling pathway_Homo sapiens_hsa04024	0.49185673
81	Sulfur relay system_Homo sapiens_hsa04122	0.48477439
82	Basal cell carcinoma_Homo sapiens_hsa05217	0.47142945
83	Purine metabolism_Homo sapiens_hsa00230	0.45785906
84	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.45472560
85	Ribosome_Homo sapiens_hsa03010	0.45002791
86	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.44532837
87	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.42419207
88	One carbon pool by folate_Homo sapiens_hsa00670	0.42147100
89	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.40003106
90	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.39905212
91	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.35706037
92	Circadian rhythm_Homo sapiens_hsa04710	0.35463544
93	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.34745885
94	Long-term depression_Homo sapiens_hsa04730	0.33500462
95	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.32749502
96	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.31677903
97	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.30805271
98	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.30610356
99	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.30455761
100	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.28370406

PCDHGB8P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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