ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of action potential (GO:0045760)	6.22156778
2	tachykinin receptor signaling pathway (GO:0007217)	4.89971717
3	positive regulation of uterine smooth muscle contraction (GO:0070474)	4.44472764
4	urinary tract smooth muscle contraction (GO:0014848)	4.39456826
5	regulation of action potential (GO:0098900)	4.02048195
6	histone H2A acetylation (GO:0043968)	3.98379968
7	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.94913467
8	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.94913467
9	regulation of translation, ncRNA-mediated (GO:0045974)	3.94913467
10	limb bud formation (GO:0060174)	3.83283843
11	head development (GO:0060322)	3.64991271
12	positive regulation of vascular permeability (GO:0043117)	3.49222925
13	adult feeding behavior (GO:0008343)	3.47421945
14	regulation of uterine smooth muscle contraction (GO:0070472)	3.40873109
15	pyrimidine dimer repair (GO:0006290)	3.40188037
16	cardiac right ventricle morphogenesis (GO:0003215)	3.37660352
17	retinal rod cell development (GO:0046548)	3.35175436
18	cerebral cortex radially oriented cell migration (GO:0021799)	3.27624977
19	regulation of timing of cell differentiation (GO:0048505)	3.27493409
20	intraciliary transport (GO:0042073)	3.21947426
21	positive regulation of digestive system process (GO:0060456)	3.16542350
22	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	3.06545330
23	pyrimidine nucleobase catabolic process (GO:0006208)	3.03957027
24	negative regulation of protein localization to cell surface (GO:2000009)	3.02034314
25	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.99632322
26	aggressive behavior (GO:0002118)	2.94370614
27	DNA double-strand break processing (GO:0000729)	2.94299988
28	central nervous system projection neuron axonogenesis (GO:0021952)	2.93953105
29	regulation of development, heterochronic (GO:0040034)	2.93203950
30	otic vesicle formation (GO:0030916)	2.86769322
31	drinking behavior (GO:0042756)	2.86186730
32	ventricular trabecula myocardium morphogenesis (GO:0003222)	2.85068956
33	sympathetic nervous system development (GO:0048485)	2.83726430
34	positive regulation of cardiac muscle cell differentiation (GO:2000727)	2.76435185
35	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	2.75759532
36	retinal cone cell development (GO:0046549)	2.74575816
37	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	2.72796151
38	fibroblast migration (GO:0010761)	2.72578972
39	atrial septum morphogenesis (GO:0060413)	2.71949380
40	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.71374843
41	cerebral cortex cell migration (GO:0021795)	2.68409813
42	photoreceptor cell maintenance (GO:0045494)	2.68356658
43	neuron fate commitment (GO:0048663)	2.64217018
44	regulation of cell communication by electrical coupling (GO:0010649)	2.63077323
45	reciprocal DNA recombination (GO:0035825)	2.62154235
46	reciprocal meiotic recombination (GO:0007131)	2.62154235
47	regulation of sarcomere organization (GO:0060297)	2.60468743
48	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	2.57197234
49	Notch signaling involved in heart development (GO:0061314)	2.56556988
50	cellular response to ethanol (GO:0071361)	2.54801941
51	spinal cord development (GO:0021510)	2.52462906
52	central nervous system neuron axonogenesis (GO:0021955)	2.52441790
53	adult heart development (GO:0007512)	2.47720105
54	regulation of cell proliferation involved in heart morphogenesis (GO:2000136)	2.47638998
55	limb development (GO:0060173)	2.47230463
56	appendage development (GO:0048736)	2.47230463
57	ventricular septum morphogenesis (GO:0060412)	2.45495259
58	transmission of nerve impulse (GO:0019226)	2.44538456
59	regulation of hippo signaling (GO:0035330)	2.43693464
60	negative regulation of DNA recombination (GO:0045910)	2.42500471
61	regulation of keratinocyte proliferation (GO:0010837)	2.41572747
62	behavioral response to ethanol (GO:0048149)	2.41212221
63	somite development (GO:0061053)	2.41197416
64	cardiac muscle cell development (GO:0055013)	2.40496821
65	negative regulation of systemic arterial blood pressure (GO:0003085)	2.39770562
66	positive regulation of catenin import into nucleus (GO:0035413)	2.39243116
67	nucleobase catabolic process (GO:0046113)	2.38923765
68	olfactory bulb development (GO:0021772)	2.38414001
69	artery development (GO:0060840)	2.35482311
70	negative regulation of DNA repair (GO:0045738)	2.34435773
71	nonmotile primary cilium assembly (GO:0035058)	2.33396424
72	neural tube formation (GO:0001841)	2.32792296
73	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.31721555
74	cochlea development (GO:0090102)	2.31053375
75	regulation of energy homeostasis (GO:2000505)	2.30347489
76	regulation of protein polyubiquitination (GO:1902914)	2.30083036
77	peristalsis (GO:0030432)	2.29647790
78	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.28103897
79	potassium ion export (GO:0071435)	2.27741375
80	cilium morphogenesis (GO:0060271)	2.27408687
81	cardiac cell development (GO:0055006)	2.27328809
82	mesenchymal-epithelial cell signaling (GO:0060638)	2.27166774
83	regulation of relaxation of muscle (GO:1901077)	2.26774372
84	cardiac myofibril assembly (GO:0055003)	2.25602649
85	negative regulation of neurotransmitter secretion (GO:0046929)	2.25490081
86	cardiac ventricle formation (GO:0003211)	2.25304403
87	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.25068235
88	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.24544760
89	neuronal stem cell maintenance (GO:0097150)	2.24501537
90	positive regulation of heart growth (GO:0060421)	2.22549887
91	brain morphogenesis (GO:0048854)	2.22305558
92	regulation of synaptic transmission, GABAergic (GO:0032228)	2.21266854
93	detection of calcium ion (GO:0005513)	2.19508526
94	positive regulation of male gonad development (GO:2000020)	2.19454434
95	retinal ganglion cell axon guidance (GO:0031290)	2.19029551
96	forebrain neuron differentiation (GO:0021879)	2.17680117
97	cardiac chamber formation (GO:0003207)	2.16598065
98	positive regulation of cardiac muscle tissue growth (GO:0055023)	2.16342955
99	smooth muscle contraction (GO:0006939)	2.16250632
100	presynaptic membrane assembly (GO:0097105)	2.15733561

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	4.08072985
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.74684624
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.51815192
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.50711603
5	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	3.00555212
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.82149554
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.64561319
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.37508710
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.35265328
10	GATA1_22025678_ChIP-Seq_K562_Human	2.34672328
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.29156475
12	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.24790770
13	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.20590891
14	FUS_26573619_Chip-Seq_HEK293_Human	2.11807532
15	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.06689651
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.04989502
17	SMAD4_21799915_ChIP-Seq_A2780_Human	1.98191550
18	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.97366132
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.94917403
20	VDR_22108803_ChIP-Seq_LS180_Human	1.94178404
21	P300_19829295_ChIP-Seq_ESCs_Human	1.91810561
22	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.90360363
23	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.81398805
24	STAT3_23295773_ChIP-Seq_U87_Human	1.79927123
25	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.78000093
26	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.74285985
27	IGF1R_20145208_ChIP-Seq_DFB_Human	1.73605309
28	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.70915841
29	EWS_26573619_Chip-Seq_HEK293_Human	1.66074928
30	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.64690131
31	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.64449709
32	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.60061645
33	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.59738424
34	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.58569943
35	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.58261169
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.55924696
37	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.53606307
38	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.49639576
39	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.49352942
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.49056332
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.49056332
42	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.48732763
43	ER_23166858_ChIP-Seq_MCF-7_Human	1.46366043
44	TCF4_23295773_ChIP-Seq_U87_Human	1.46286316
45	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.44090566
46	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.44090566
47	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.43366506
48	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.42676137
49	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.40877537
50	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.38731052
51	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.38582096
52	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.38424300
53	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.38391495
54	AR_25329375_ChIP-Seq_VCAP_Human	1.38114153
55	RUNX2_22187159_ChIP-Seq_PCA_Human	1.35448632
56	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.34303401
57	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.34025361
58	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.33960394
59	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.31830657
60	CJUN_26792858_Chip-Seq_BT549_Human	1.30993111
61	BCAT_22108803_ChIP-Seq_LS180_Human	1.28342880
62	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.28239737
63	TP53_18474530_ChIP-ChIP_U2OS_Human	1.22435635
64	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.21766395
65	TP53_16413492_ChIP-PET_HCT116_Human	1.20884277
66	ELK1_19687146_ChIP-ChIP_HELA_Human	1.20881641
67	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.19437987
68	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.19242019
69	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.18942953
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.18395141
71	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.16065520
72	RNF2_27304074_Chip-Seq_NSC_Mouse	1.15589290
73	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15057138
74	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.15057138
75	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.14964987
76	RXR_22108803_ChIP-Seq_LS180_Human	1.14810309
77	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.14336977
78	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.13458022
79	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.12570044
80	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.11754473
81	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.10814459
82	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10265846
83	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.09918406
84	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.07510152
85	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.07243929
86	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.06414568
87	AHR_22903824_ChIP-Seq_MCF-7_Human	1.05999889
88	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.05979960
89	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05035527
90	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.04478051
91	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.03682336
92	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.03198658
93	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.02987690
94	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.02892910
95	KDM2B_26808549_Chip-Seq_REH_Human	1.02561244
96	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.02421111
97	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02231420
98	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.00021844
99	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.98926930
100	SOX9_26525672_Chip-Seq_HEART_Mouse	0.98155547

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002736_abnormal_nociception_after	3.49267946
2	MP0005248_abnormal_Harderian_gland	3.19056287
3	MP0005367_renal/urinary_system_phenotyp	2.65423701
4	MP0000516_abnormal_urinary_system	2.65423701
5	MP0002735_abnormal_chemical_nociception	2.64368466
6	MP0001968_abnormal_touch/_nociception	2.57079165
7	MP0003941_abnormal_skin_development	2.47480377
8	MP0002102_abnormal_ear_morphology	2.33531902
9	MP0004270_analgesia	2.24429189
10	MP0001529_abnormal_vocalization	2.23628099
11	MP0000751_myopathy	2.11162175
12	MP0002277_abnormal_respiratory_mucosa	1.99597620
13	MP0003646_muscle_fatigue	1.97393210
14	MP0000749_muscle_degeneration	1.92191083
15	MP0000049_abnormal_middle_ear	1.88112683
16	MP0002734_abnormal_mechanical_nocicepti	1.84596508
17	MP0001299_abnormal_eye_distance/	1.76756164
18	MP0003755_abnormal_palate_morphology	1.76511863
19	MP0002751_abnormal_autonomic_nervous	1.72900620
20	MP0003385_abnormal_body_wall	1.72553002
21	MP0010030_abnormal_orbit_morphology	1.72408424
22	MP0008789_abnormal_olfactory_epithelium	1.70751477
23	MP0000569_abnormal_digit_pigmentation	1.67309632
24	MP0000778_abnormal_nervous_system	1.62736883
25	MP0003950_abnormal_plasma_membrane	1.57195836
26	MP0005253_abnormal_eye_physiology	1.52130301
27	MP0003937_abnormal_limbs/digits/tail_de	1.49928224
28	MP0004215_abnormal_myocardial_fiber	1.47422850
29	MP0002233_abnormal_nose_morphology	1.44460250
30	MP0005394_taste/olfaction_phenotype	1.42236504
31	MP0005499_abnormal_olfactory_system	1.42236504
32	MP0002938_white_spotting	1.39468377
33	MP0003935_abnormal_craniofacial_develop	1.34216913
34	MP0005187_abnormal_penis_morphology	1.32990954
35	MP0004145_abnormal_muscle_electrophysio	1.31268891
36	MP0004233_abnormal_muscle_weight	1.30710200
37	MP0003567_abnormal_fetal_cardiomyocyte	1.29570643
38	MP0010368_abnormal_lymphatic_system	1.29186132
39	MP0004510_myositis	1.22627427
40	MP0008877_abnormal_DNA_methylation	1.21854461
41	MP0002106_abnormal_muscle_physiology	1.19431573
42	MP0002332_abnormal_exercise_endurance	1.18605634
43	MP0005623_abnormal_meninges_morphology	1.17072066
44	MP0004085_abnormal_heartbeat	1.16460012
45	MP0001485_abnormal_pinna_reflex	1.14830604
46	MP0006276_abnormal_autonomic_nervous	1.14719877
47	MP0005369_muscle_phenotype	1.13826502
48	MP0002108_abnormal_muscle_morphology	1.12523891
49	MP0001286_abnormal_eye_development	1.11397373
50	MP0004142_abnormal_muscle_tone	1.09867844
51	MP0002177_abnormal_outer_ear	1.07492653
52	MP0003195_calcinosis	1.06708047
53	MP0002269_muscular_atrophy	1.02254714
54	MP0009780_abnormal_chondrocyte_physiolo	0.98860753
55	MP0001984_abnormal_olfaction	0.97350285
56	MP0000733_abnormal_muscle_development	0.95576393
57	MP0002184_abnormal_innervation	0.94515546
58	MP0009384_cardiac_valve_regurgitation	0.94480640
59	MP0003938_abnormal_ear_development	0.93418225
60	MP0008058_abnormal_DNA_repair	0.93335634
61	MP0001661_extended_life_span	0.92814116
62	MP0004084_abnormal_cardiac_muscle	0.92678943
63	MP0000631_abnormal_neuroendocrine_gland	0.92555910
64	MP0001486_abnormal_startle_reflex	0.91778859
65	MP0009250_abnormal_appendicular_skeleto	0.91204992
66	MP0001177_atelectasis	0.91071880
67	MP0003045_fibrosis	0.89568988
68	MP0002168_other_aberrant_phenotype	0.88792343
69	MP0003122_maternal_imprinting	0.88785925
70	MP0002282_abnormal_trachea_morphology	0.88664920
71	MP0002272_abnormal_nervous_system	0.87051509
72	MP0000432_abnormal_head_morphology	0.85951441
73	MP0005620_abnormal_muscle_contractility	0.85596701
74	MP0002127_abnormal_cardiovascular_syste	0.84321505
75	MP0002638_abnormal_pupillary_reflex	0.84037010
76	MP0000767_abnormal_smooth_muscle	0.83880953
77	MP0001879_abnormal_lymphatic_vessel	0.83745592
78	MP0000534_abnormal_ureter_morphology	0.83324068
79	MP0000759_abnormal_skeletal_muscle	0.83222690
80	MP0005551_abnormal_eye_electrophysiolog	0.82879860
81	MP0002752_abnormal_somatic_nervous	0.82036507
82	MP0002067_abnormal_sensory_capabilities	0.81993733
83	MP0006072_abnormal_retinal_apoptosis	0.81523386
84	MP0010352_gastrointestinal_tract_polyps	0.80906012
85	MP0003861_abnormal_nervous_system	0.80858059
86	MP0009046_muscle_twitch	0.78761509
87	MP0004272_abnormal_basement_membrane	0.76714823
88	MP0003635_abnormal_synaptic_transmissio	0.76691571
89	MP0004036_abnormal_muscle_relaxation	0.75847863
90	MP0003119_abnormal_digestive_system	0.75687941
91	MP0002837_dystrophic_cardiac_calcinosis	0.74875594
92	MP0000428_abnormal_craniofacial_morphol	0.74342486
93	MP0005391_vision/eye_phenotype	0.74103925
94	MP0000026_abnormal_inner_ear	0.74047494
95	MP0009703_decreased_birth_body	0.73372466
96	MP0003868_abnormal_feces_composition	0.72986368
97	MP0005386_behavior/neurological_phenoty	0.72634683
98	MP0004924_abnormal_behavior	0.72634683
99	MP0004043_abnormal_pH_regulation	0.72246703
100	MP0004087_abnormal_muscle_fiber	0.71783004

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	3.85508949
2	Decreased lacrimation (HP:0000633)	3.84924500
3	Hepatoblastoma (HP:0002884)	3.34552767
4	Colon cancer (HP:0003003)	3.15375078
5	Gait imbalance (HP:0002141)	2.96887905
6	Nephrogenic diabetes insipidus (HP:0009806)	2.88653179
7	Dry hair (HP:0011359)	2.84949888
8	True hermaphroditism (HP:0010459)	2.79235900
9	Abnormality of the ischium (HP:0003174)	2.78025519
10	Congenital primary aphakia (HP:0007707)	2.73116500
11	Medial flaring of the eyebrow (HP:0010747)	2.72206675
12	Hypoplastic ischia (HP:0003175)	2.68665041
13	Genital tract atresia (HP:0001827)	2.65604408
14	Cystic hygroma (HP:0000476)	2.64916005
15	Rimmed vacuoles (HP:0003805)	2.55698742
16	Pancreatic fibrosis (HP:0100732)	2.53968336
17	Tubulointerstitial nephritis (HP:0001970)	2.51135480
18	Vaginal atresia (HP:0000148)	2.46831274
19	Pancreatic cysts (HP:0001737)	2.44621989
20	Exotropia (HP:0000577)	2.44405651
21	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.40013820
22	3-Methylglutaconic aciduria (HP:0003535)	2.37100847
23	Thyroid-stimulating hormone excess (HP:0002925)	2.36093805
24	Poikiloderma (HP:0001029)	2.33572663
25	Gaze-evoked nystagmus (HP:0000640)	2.33453818
26	Papillary thyroid carcinoma (HP:0002895)	2.31407542
27	Chronic hepatic failure (HP:0100626)	2.30509052
28	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.28664468
29	Chorioretinal atrophy (HP:0000533)	2.26851374
30	Abnormality of the astrocytes (HP:0100707)	2.26048289
31	Astrocytoma (HP:0009592)	2.26048289
32	Alacrima (HP:0000522)	2.24617587
33	Long clavicles (HP:0000890)	2.23902660
34	Intestinal atresia (HP:0011100)	2.21403144
35	Nephronophthisis (HP:0000090)	2.20798671
36	Poor coordination (HP:0002370)	2.16570412
37	Congenital hepatic fibrosis (HP:0002612)	2.16281591
38	Widely spaced teeth (HP:0000687)	2.13136300
39	Neoplasm of the oral cavity (HP:0100649)	2.12763795
40	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.08099148
41	Short foot (HP:0001773)	2.06686851
42	Abnormality of the renal medulla (HP:0100957)	2.06242808
43	Postaxial foot polydactyly (HP:0001830)	2.04492040
44	Facial cleft (HP:0002006)	2.02497408
45	Hypoplastic iliac wings (HP:0002866)	2.02095814
46	Febrile seizures (HP:0002373)	2.01375602
47	Aortic aneurysm (HP:0004942)	1.99972984
48	Abnormality of the antihelix (HP:0009738)	1.99952239
49	Aplasia/Hypoplasia of the lens (HP:0008063)	1.98644883
50	Postaxial hand polydactyly (HP:0001162)	1.98324778
51	Abnormality of the labia minora (HP:0012880)	1.97852940
52	Absent speech (HP:0001344)	1.90214509
53	Glioma (HP:0009733)	1.89804807
54	Left ventricular hypertrophy (HP:0001712)	1.89704952
55	Prolonged QT interval (HP:0001657)	1.89504461
56	Hypoplastic pelvis (HP:0008839)	1.89402919
57	Nemaline bodies (HP:0003798)	1.89078499
58	Abnormality of the calf musculature (HP:0001430)	1.87700423
59	Micropenis (HP:0000054)	1.87518101
60	Drooling (HP:0002307)	1.86590776
61	Optic nerve hypoplasia (HP:0000609)	1.86364657
62	Calf muscle hypertrophy (HP:0008981)	1.83750654
63	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.83388694
64	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.83388694
65	Entropion (HP:0000621)	1.83105175
66	Limited hip movement (HP:0008800)	1.82784628
67	Neoplasm of the adrenal cortex (HP:0100641)	1.80769678
68	Pendular nystagmus (HP:0012043)	1.80653675
69	Small hand (HP:0200055)	1.80396693
70	Broad-based gait (HP:0002136)	1.80337017
71	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	1.80164965
72	Sudden death (HP:0001699)	1.79548900
73	Arterial tortuosity (HP:0005116)	1.78892975
74	Median cleft lip (HP:0000161)	1.76269610
75	Microglossia (HP:0000171)	1.76182815
76	Atrial fibrillation (HP:0005110)	1.75172857
77	Thyroid carcinoma (HP:0002890)	1.74538249
78	Muscle fiber inclusion bodies (HP:0100299)	1.73595457
79	Syncope (HP:0001279)	1.72287485
80	Portal hypertension (HP:0001409)	1.72136296
81	Abnormality of the labia majora (HP:0012881)	1.70525566
82	Absent hand (HP:0004050)	1.70058650
83	Steppage gait (HP:0003376)	1.66123091
84	Short tibia (HP:0005736)	1.64353566
85	Polyphagia (HP:0002591)	1.64176230
86	Focal motor seizures (HP:0011153)	1.62577573
87	Obsessive-compulsive behavior (HP:0000722)	1.62418370
88	Broad foot (HP:0001769)	1.61913297
89	Muscle hypertrophy of the lower extremities (HP:0008968)	1.61620570
90	Mildly elevated creatine phosphokinase (HP:0008180)	1.60897826
91	Abnormality of the pubic bones (HP:0003172)	1.60878191
92	Gonadotropin excess (HP:0000837)	1.60857016
93	Short 1st metacarpal (HP:0010034)	1.60375805
94	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.60375805
95	Bony spicule pigmentary retinopathy (HP:0007737)	1.58916459
96	Type 1 muscle fiber predominance (HP:0003803)	1.58839160
97	Preaxial hand polydactyly (HP:0001177)	1.58718815
98	Bifid tongue (HP:0010297)	1.58387493
99	Protruding tongue (HP:0010808)	1.58338499
100	Excessive salivation (HP:0003781)	1.57410866

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	4.67407339
2	FRK	3.92810484
3	STK38L	3.25561816
4	AKT3	3.12578815
5	BRD4	2.78876882
6	MAPK13	2.71891885
7	OBSCN	2.51964261
8	BRSK2	2.38548512
9	MAP3K4	2.19494781
10	LATS1	2.05307586
11	WNK3	2.03926675
12	CASK	2.02226648
13	TGFBR2	1.99619909
14	STK39	1.82968302
15	NUAK1	1.82116359
16	SGK2	1.81645856
17	PIM2	1.80159893
18	CCNB1	1.58276079
19	CAMKK2	1.52492065
20	BCR	1.40167405
21	BMPR1B	1.36478482
22	MKNK2	1.34420248
23	SGK494	1.30926764
24	SGK223	1.30926764
25	MAP2K7	1.21349714
26	SGK3	1.18910860
27	PHKG1	1.18863015
28	PHKG2	1.18863015
29	PAK3	1.12859791
30	CSNK1A1L	1.12713595
31	PLK2	1.07688885
32	ERBB3	1.07021254
33	PIK3CA	1.06602779
34	PRKCE	1.06537208
35	NEK9	1.05666018
36	CSNK1G1	1.05396460
37	MAP3K7	1.04611660
38	NTRK3	1.03796832
39	DYRK1B	0.98343301
40	MAP2K4	0.97997186
41	OXSR1	0.95433065
42	ROCK1	0.91395120
43	MYLK	0.90380427
44	CSNK1G2	0.89428908
45	DYRK2	0.86585368
46	MAP4K2	0.86394739
47	MAP3K6	0.85959479
48	MKNK1	0.83844916
49	PRKAA2	0.83771832
50	CSNK1G3	0.82176358
51	TNIK	0.81510849
52	EPHB2	0.74505648
53	SRPK1	0.73822581
54	STK3	0.73533230
55	DAPK3	0.70387662
56	DAPK2	0.67292486
57	PRKCG	0.65382426
58	TRIM28	0.65381453
59	DMPK	0.64660312
60	MAP3K5	0.64580237
61	INSRR	0.64323552
62	PRKAA1	0.58831346
63	CDK6	0.58535378
64	ADRBK1	0.56624810
65	EIF2AK3	0.56323289
66	DDR2	0.56174516
67	GRK7	0.55687257
68	GRK1	0.54798199
69	MAP3K12	0.54416625
70	NTRK2	0.54257451
71	STK38	0.52653279
72	VRK1	0.50915114
73	PKN1	0.50476577
74	BRSK1	0.48985484
75	CAMK2B	0.48079124
76	RPS6KB1	0.47670340
77	CSNK1D	0.47170597
78	PRKD3	0.46795158
79	ERBB4	0.45052420
80	PDGFRA	0.44496828
81	ABL1	0.44477940
82	MET	0.44400973
83	PRKG1	0.42744245
84	CDK8	0.42240819
85	DYRK1A	0.42084532
86	ADRBK2	0.40653914
87	SGK1	0.39881038
88	NEK6	0.39863507
89	PDGFRB	0.39184297
90	ATM	0.38113493
91	MAPK10	0.37510068
92	PRKACA	0.36385583
93	CAMK4	0.36192165
94	CAMK2A	0.35392919
95	PRKACB	0.34850010
96	FGFR1	0.34574172
97	RPS6KA3	0.34337295
98	CAMK2D	0.34290036
99	MAPK4	0.33364623
100	CDK5	0.32486577

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	2.93033029
2	Taste transduction_Homo sapiens_hsa04742	2.81700321
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.49486959
4	Circadian rhythm_Homo sapiens_hsa04710	2.28987319
5	Propanoate metabolism_Homo sapiens_hsa00640	2.27577948
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.03814777
7	Butanoate metabolism_Homo sapiens_hsa00650	2.00529922
8	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.98542510
9	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.92072460
10	Glutamatergic synapse_Homo sapiens_hsa04724	1.90540796
11	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.87427674
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.81559170
13	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.59840355
14	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.48445816
15	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.47218372
16	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.45190196
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.43829167
18	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.43674798
19	GABAergic synapse_Homo sapiens_hsa04727	1.43669197
20	Homologous recombination_Homo sapiens_hsa03440	1.41744389
21	Amphetamine addiction_Homo sapiens_hsa05031	1.41062312
22	Circadian entrainment_Homo sapiens_hsa04713	1.40777264
23	beta-Alanine metabolism_Homo sapiens_hsa00410	1.39621815
24	Calcium signaling pathway_Homo sapiens_hsa04020	1.37619428
25	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.31660567
26	Retinol metabolism_Homo sapiens_hsa00830	1.30762736
27	ABC transporters_Homo sapiens_hsa02010	1.30677841
28	Basal transcription factors_Homo sapiens_hsa03022	1.27785743
29	Dopaminergic synapse_Homo sapiens_hsa04728	1.27440729
30	Melanoma_Homo sapiens_hsa05218	1.21633925
31	Linoleic acid metabolism_Homo sapiens_hsa00591	1.20115702
32	Protein digestion and absorption_Homo sapiens_hsa04974	1.18570207
33	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.13458078
34	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.13172973
35	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.13058945
36	Hippo signaling pathway_Homo sapiens_hsa04390	1.08741041
37	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.08613722
38	Non-homologous end-joining_Homo sapiens_hsa03450	1.07628985
39	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.06951678
40	Basal cell carcinoma_Homo sapiens_hsa05217	1.03411627
41	Axon guidance_Homo sapiens_hsa04360	1.02272747
42	ECM-receptor interaction_Homo sapiens_hsa04512	1.01197388
43	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.00579990
44	Adherens junction_Homo sapiens_hsa04520	0.98433014
45	Lysine degradation_Homo sapiens_hsa00310	0.97665541
46	Morphine addiction_Homo sapiens_hsa05032	0.94694294
47	Tight junction_Homo sapiens_hsa04530	0.94624400
48	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.93717257
49	Long-term depression_Homo sapiens_hsa04730	0.93444162
50	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.90538100
51	cAMP signaling pathway_Homo sapiens_hsa04024	0.90525584
52	Regulation of autophagy_Homo sapiens_hsa04140	0.86654201
53	Phototransduction_Homo sapiens_hsa04744	0.86184898
54	Pancreatic secretion_Homo sapiens_hsa04972	0.85883380
55	Nitrogen metabolism_Homo sapiens_hsa00910	0.85150807
56	ErbB signaling pathway_Homo sapiens_hsa04012	0.84765491
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.84560630
58	Renin-angiotensin system_Homo sapiens_hsa04614	0.81789278
59	Renin secretion_Homo sapiens_hsa04924	0.81226307
60	MicroRNAs in cancer_Homo sapiens_hsa05206	0.80891155
61	Ether lipid metabolism_Homo sapiens_hsa00565	0.79223363
62	Nucleotide excision repair_Homo sapiens_hsa03420	0.74937478
63	Alcoholism_Homo sapiens_hsa05034	0.74196124
64	Chemical carcinogenesis_Homo sapiens_hsa05204	0.74108617
65	Long-term potentiation_Homo sapiens_hsa04720	0.73398864
66	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.72043429
67	Wnt signaling pathway_Homo sapiens_hsa04310	0.71560426
68	FoxO signaling pathway_Homo sapiens_hsa04068	0.69650943
69	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.67941398
70	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.67650309
71	Colorectal cancer_Homo sapiens_hsa05210	0.66767378
72	Cocaine addiction_Homo sapiens_hsa05030	0.66132056
73	Focal adhesion_Homo sapiens_hsa04510	0.65225630
74	p53 signaling pathway_Homo sapiens_hsa04115	0.61983818
75	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.61314743
76	Oocyte meiosis_Homo sapiens_hsa04114	0.60849541
77	Serotonergic synapse_Homo sapiens_hsa04726	0.60231411
78	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.59272940
79	Fatty acid degradation_Homo sapiens_hsa00071	0.58611524
80	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.58453496
81	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.58273109
82	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.56624769
83	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.56225998
84	Glioma_Homo sapiens_hsa05214	0.55871253
85	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.55225131
86	Selenocompound metabolism_Homo sapiens_hsa00450	0.53952411
87	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.53356726
88	Gap junction_Homo sapiens_hsa04540	0.51566627
89	Caffeine metabolism_Homo sapiens_hsa00232	0.50700622
90	Olfactory transduction_Homo sapiens_hsa04740	0.48962926
91	Glycerolipid metabolism_Homo sapiens_hsa00561	0.48949284
92	Tryptophan metabolism_Homo sapiens_hsa00380	0.48274515
93	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.48231744
94	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.47679100
95	Cardiac muscle contraction_Homo sapiens_hsa04260	0.47296453
96	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.45846373
97	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.45696726
98	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.44485261
99	Sphingolipid metabolism_Homo sapiens_hsa00600	0.44211151
100	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.43894726

PCDHGB9P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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