PCDHGC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1postsynaptic membrane organization (GO:0001941)6.02784514
2presynaptic membrane assembly (GO:0097105)4.54921358
3L-amino acid import (GO:0043092)4.41599290
4amino acid import (GO:0043090)4.40783135
5neuron cell-cell adhesion (GO:0007158)4.25005057
6axon ensheathment in central nervous system (GO:0032291)4.22669215
7central nervous system myelination (GO:0022010)4.22669215
8presynaptic membrane organization (GO:0097090)4.17996460
9protein heterotrimerization (GO:0070208)4.09163004
10glutamate secretion (GO:0014047)3.98920391
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.94064269
12potassium ion homeostasis (GO:0055075)3.92573372
13regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.85310179
14potassium ion import (GO:0010107)3.83967111
15dermatan sulfate biosynthetic process (GO:0030208)3.82968341
16chondrocyte proliferation (GO:0035988)3.78935119
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.77061876
18regulation of synaptic vesicle exocytosis (GO:2000300)3.76202228
19layer formation in cerebral cortex (GO:0021819)3.69891017
20axon extension involved in axon guidance (GO:0048846)3.66587359
21neuron projection extension involved in neuron projection guidance (GO:1902284)3.66587359
22synaptic vesicle exocytosis (GO:0016079)3.64546961
23regulation of short-term neuronal synaptic plasticity (GO:0048172)3.60520584
24locomotory exploration behavior (GO:0035641)3.57566193
25negative regulation of catenin import into nucleus (GO:0035414)3.54757154
26collagen fibril organization (GO:0030199)3.53352875
27membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.50713234
28dermatan sulfate metabolic process (GO:0030205)3.48177923
29ionotropic glutamate receptor signaling pathway (GO:0035235)3.48111124
30establishment of nucleus localization (GO:0040023)3.40969012
31planar cell polarity pathway involved in neural tube closure (GO:0090179)3.38299324
32plasma membrane repair (GO:0001778)3.38037774
33astrocyte development (GO:0014002)3.29306644
34glial cell proliferation (GO:0014009)3.29292130
35regulation of neuronal synaptic plasticity (GO:0048168)3.28186630
36neuronal ion channel clustering (GO:0045161)3.27269661
37endodermal cell differentiation (GO:0035987)3.25596161
38regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.24222793
39auditory behavior (GO:0031223)3.23964100
40regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.22569686
41positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.20125002
42hippo signaling (GO:0035329)3.18745691
43cytoskeletal anchoring at plasma membrane (GO:0007016)3.18540711
44neurotransmitter-gated ion channel clustering (GO:0072578)3.17382969
45membrane assembly (GO:0071709)3.15811712
46cellular sodium ion homeostasis (GO:0006883)3.14280289
47regulation of glutamate receptor signaling pathway (GO:1900449)3.13562683
48regulation of synaptic vesicle transport (GO:1902803)3.13107242
49negative regulation of fatty acid transport (GO:2000192)3.11396969
50neuromuscular process controlling balance (GO:0050885)3.08801898
51insulin-like growth factor receptor signaling pathway (GO:0048009)3.07588574
52outer ear morphogenesis (GO:0042473)3.07290908
53neuron recognition (GO:0008038)3.07105875
54negative regulation of synaptic transmission, GABAergic (GO:0032229)3.06527745
55bone trabecula formation (GO:0060346)3.05745316
56dendrite morphogenesis (GO:0048813)3.04232932
57neurotransmitter uptake (GO:0001504)2.99554498
58neuron projection regeneration (GO:0031102)2.99492907
59chondroitin sulfate catabolic process (GO:0030207)2.96460072
60sequestering of extracellular ligand from receptor (GO:0035581)2.93026745
61regulation of respiratory system process (GO:0044065)2.90748548
62synaptic transmission, glutamatergic (GO:0035249)2.89065837
63innervation (GO:0060384)2.88400084
64neurotransmitter secretion (GO:0007269)2.88337721
65sodium ion export (GO:0071436)2.88139099
66regulation of long-term neuronal synaptic plasticity (GO:0048169)2.87547946
67neuronal action potential propagation (GO:0019227)2.87386545
68acidic amino acid transport (GO:0015800)2.86450939
69negative regulation of sodium ion transport (GO:0010766)2.85957629
70polarized epithelial cell differentiation (GO:0030859)2.85574885
71protein localization to synapse (GO:0035418)2.84474351
72negative regulation of chondrocyte differentiation (GO:0032331)2.82173736
73stress fiber assembly (GO:0043149)2.81521582
74oligodendrocyte differentiation (GO:0048709)2.81201723
75semaphorin-plexin signaling pathway (GO:0071526)2.78327482
76response to auditory stimulus (GO:0010996)2.76237115
77lens fiber cell development (GO:0070307)2.74040060
78cell communication by electrical coupling (GO:0010644)2.72034246
79craniofacial suture morphogenesis (GO:0097094)2.70792773
80positive regulation of axon extension (GO:0045773)2.69782850
81G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.68626565
82dendritic spine morphogenesis (GO:0060997)2.68624974
83cerebellar granule cell differentiation (GO:0021707)2.68003978
84basement membrane organization (GO:0071711)2.67273957
85heparan sulfate proteoglycan metabolic process (GO:0030201)2.66687978
86positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.66663362
87positive regulation of synapse assembly (GO:0051965)2.66586179
88regulation of synapse structural plasticity (GO:0051823)2.66579443
89heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.65935474
90positive regulation of dendritic spine development (GO:0060999)2.65409548
91mechanosensory behavior (GO:0007638)2.64437396
92mesenchymal-epithelial cell signaling (GO:0060638)2.64103400
93positive regulation of glycogen biosynthetic process (GO:0045725)2.62355843
94ovulation cycle (GO:0042698)2.62340656
95cerebellar Purkinje cell layer development (GO:0021680)2.61474793
96negative regulation of smooth muscle cell migration (GO:0014912)2.61092119
97regulation of axon extension involved in axon guidance (GO:0048841)2.60240882
98camera-type eye morphogenesis (GO:0048593)2.59112017
99axonal fasciculation (GO:0007413)2.58888584
100regulation of synaptic plasticity (GO:0048167)2.57815273
101regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.55863491
102collagen metabolic process (GO:0032963)2.55742601
103peripheral nervous system axon ensheathment (GO:0032292)2.54251799
104myelination in peripheral nervous system (GO:0022011)2.54251799
105metanephric mesenchyme development (GO:0072075)2.53700847
106synaptic vesicle maturation (GO:0016188)2.53406715
107L-glutamate transport (GO:0015813)2.53328192
108response to gravity (GO:0009629)2.53194958
109astrocyte differentiation (GO:0048708)2.53068594
110collagen catabolic process (GO:0030574)2.52507666
111regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.51821372
112negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.51276465
113regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.51197021
114eye photoreceptor cell differentiation (GO:0001754)2.51093216
115photoreceptor cell differentiation (GO:0046530)2.51093216
116axon ensheathment (GO:0008366)2.51074312
117ensheathment of neurons (GO:0007272)2.51074312
118myelination (GO:0042552)2.50557799
119positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.50301851
120axon extension (GO:0048675)2.48971877
121glutamate receptor signaling pathway (GO:0007215)2.48069191
122synaptic vesicle endocytosis (GO:0048488)2.47945973
123cell adhesion mediated by integrin (GO:0033627)2.47171545
124regulation of synaptic transmission, glutamatergic (GO:0051966)2.46597363
125multicellular organismal macromolecule metabolic process (GO:0044259)2.46122760
126negative regulation of axonogenesis (GO:0050771)2.45701121
127collecting duct development (GO:0072044)2.45136533
128chondroitin sulfate biosynthetic process (GO:0030206)2.44031051
129glial cell differentiation (GO:0010001)2.43299461
130Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.43063180
131adherens junction assembly (GO:0034333)2.42114512
132cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.41788190
133positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.41621907
134negative regulation of cell size (GO:0045792)2.41610944
135chondrocyte development (GO:0002063)2.41280581
136paraxial mesoderm development (GO:0048339)2.41202559
137positive regulation of fibroblast migration (GO:0010763)2.41037157
138positive regulation of osteoblast proliferation (GO:0033690)2.40305557
139positive regulation of membrane potential (GO:0045838)2.40107794
140regulation of respiratory gaseous exchange (GO:0043576)2.39906426
141neurotransmitter transport (GO:0006836)2.39658606
142regulation of excitatory postsynaptic membrane potential (GO:0060079)2.39401251
143regulation of establishment of planar polarity (GO:0090175)2.38635559
144exploration behavior (GO:0035640)2.38577366
145kidney mesenchyme development (GO:0072074)2.37727068
146positive regulation of synapse maturation (GO:0090129)2.37629103
147protein targeting to plasma membrane (GO:0072661)2.37183588
148regulation of axon guidance (GO:1902667)2.35477418
149cell migration in hindbrain (GO:0021535)2.35457602
150cochlea morphogenesis (GO:0090103)2.33671033
151apoptotic cell clearance (GO:0043277)2.33343820
152synaptic vesicle docking involved in exocytosis (GO:0016081)2.30713510
153cellular response to cholesterol (GO:0071397)2.30709927
154neuromuscular junction development (GO:0007528)2.29683920
155myoblast fusion (GO:0007520)2.28331365
156multicellular organismal metabolic process (GO:0044236)2.28055685
157multicellular organismal catabolic process (GO:0044243)2.28047983
158regulation of catenin import into nucleus (GO:0035412)2.27398431
159extracellular matrix disassembly (GO:0022617)2.25391276
160skin morphogenesis (GO:0043589)2.24396060
161cellular potassium ion homeostasis (GO:0030007)2.23865499
162negative regulation of smoothened signaling pathway (GO:0045879)2.23479307
163negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.23203161
164non-canonical Wnt signaling pathway (GO:0035567)2.23072761
165vocalization behavior (GO:0071625)2.22517928
166positive regulation of mesenchymal cell proliferation (GO:0002053)2.21824715
167negative regulation of cartilage development (GO:0061037)2.20333261
168central nervous system projection neuron axonogenesis (GO:0021952)2.19794945

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.34608368
2EZH2_22144423_ChIP-Seq_EOC_Human3.01154305
3TP63_17297297_ChIP-ChIP_HaCaT_Human2.66601825
4RNF2_18974828_ChIP-Seq_MESCs_Mouse2.43352303
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.43352303
6WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.42681364
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.40335846
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.36100371
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.31378596
10EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.27303481
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.18086681
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.15916044
13* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.11290187
14* EED_16625203_ChIP-ChIP_MESCs_Mouse2.10326043
15ZFP281_18757296_ChIP-ChIP_E14_Mouse2.06862715
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.06821415
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.06459879
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06348964
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.02157511
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.98245078
21* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.95196504
22DROSHA_22980978_ChIP-Seq_HELA_Human1.93781149
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.89882582
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.89519168
25ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.89328979
26CLOCK_20551151_ChIP-Seq_293T_Human1.88045959
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.86683986
28REST_21632747_ChIP-Seq_MESCs_Mouse1.84415146
29TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.79740857
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76725505
31KDM2B_26808549_Chip-Seq_K562_Human1.74538075
32DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.69234503
33RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.69181180
34ZFP281_27345836_Chip-Seq_ESCs_Mouse1.68564679
35TP53_20018659_ChIP-ChIP_R1E_Mouse1.68182144
36AR_21572438_ChIP-Seq_LNCaP_Human1.67672677
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.63105489
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.62068376
39* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.60758919
40ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.60472347
41SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.59740512
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57770816
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.54870101
44EP300_21415370_ChIP-Seq_HL-1_Mouse1.52738356
45REST_18959480_ChIP-ChIP_MESCs_Mouse1.50419593
46* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50348272
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.49192069
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48796275
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.48304803
50P300_27058665_Chip-Seq_ZR-75-30cells_Human1.46633562
51WT1_25993318_ChIP-Seq_PODOCYTE_Human1.46350412
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45331836
53* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43581885
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.39936742
55* RING1B_27294783_Chip-Seq_ESCs_Mouse1.38224873
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36635086
57RING1B_27294783_Chip-Seq_NPCs_Mouse1.36521752
58EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33101504
59KDM2B_26808549_Chip-Seq_JURKAT_Human1.30212960
60RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.30186788
61ISL1_27105846_Chip-Seq_CPCs_Mouse1.29841013
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.29164886
63KDM2B_26808549_Chip-Seq_DND41_Human1.27880068
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26969942
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.25403200
66RARB_27405468_Chip-Seq_BRAIN_Mouse1.24089916
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.21923249
68SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.21765532
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.20115531
70TP53_16413492_ChIP-PET_HCT116_Human1.19898097
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19722994
72OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.16721820
73* TP53_23651856_ChIP-Seq_MEFs_Mouse1.16715701
74BRD4_25478319_ChIP-Seq_HGPS_Human1.15900536
75CJUN_26792858_Chip-Seq_BT549_Human1.15226805
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.14209769
77LXR_22292898_ChIP-Seq_THP-1_Human1.14015685
78UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12755400
79ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11731031
80RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11636431
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11235851
82ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11099345
83TET1_21490601_ChIP-Seq_MESCs_Mouse1.10452908
84GBX2_23144817_ChIP-Seq_PC3_Human1.08994427
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.07135201
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06259607
87AR_19668381_ChIP-Seq_PC3_Human1.05742076
88CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03551492
89TP53_18474530_ChIP-ChIP_U2OS_Human1.03377081
90CTCF_27219007_Chip-Seq_Bcells_Human1.03193076
91HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02993016
92NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02517683
93DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02295139
94MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01979504
95SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01858283
96TBX20_22328084_ChIP-Seq_HEART_Mouse1.01510969
97TBX20_22080862_ChIP-Seq_HEART_Mouse1.01510969
98CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01209507
99THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99751202
100RXR_22108803_ChIP-Seq_LS180_Human0.99579681
101SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99243822
102PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99176218
103NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97925531
104NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97925531
105AHR_22903824_ChIP-Seq_MCF-7_Human0.97923593
106ZNF274_21170338_ChIP-Seq_K562_Hela0.97811926
107ESR1_20079471_ChIP-ChIP_T-47D_Human0.97786786
108ZNF263_19887448_ChIP-Seq_K562_Human0.96986944
109NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96756920
110* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96329204
111EGR1_19374776_ChIP-ChIP_THP-1_Human0.96252995
112TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95760788
113KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95663158
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85358994
115SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84854684
116* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.83606310
117SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82830074
118TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82280241
119SOX2_21211035_ChIP-Seq_LN229_Gbm0.79806258
120PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79514473
121CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.79030747
122SMC4_20622854_ChIP-Seq_HELA_Human0.77478157
123GATA1_26923725_Chip-Seq_HPCs_Mouse0.76180974
124SMC3_22415368_ChIP-Seq_MEFs_Mouse0.75395126
125MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.73335662

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.46103840
2MP0003705_abnormal_hypodermis_morpholog3.75413571
3MP0005503_abnormal_tendon_morphology3.40532151
4MP0005623_abnormal_meninges_morphology3.35653549
5MP0005423_abnormal_somatic_nervous3.28629511
6MP0003880_abnormal_central_pattern3.20811583
7MP0005275_abnormal_skin_tensile3.13462280
8MP0004858_abnormal_nervous_system2.80445448
9MP0003279_aneurysm2.64281084
10MP0004859_abnormal_synaptic_plasticity2.62437367
11MP0001958_emphysema2.36859960
12MP0004272_abnormal_basement_membrane2.36401675
13MP0002064_seizures2.30828933
14MP0003690_abnormal_glial_cell2.19507532
15MP0003283_abnormal_digestive_organ2.18075658
16MP0001486_abnormal_startle_reflex2.11835381
17MP0002734_abnormal_mechanical_nocicepti2.10003788
18MP0010030_abnormal_orbit_morphology2.09943550
19MP0009780_abnormal_chondrocyte_physiolo2.05525430
20MP0001299_abnormal_eye_distance/2.03293380
21MP0009384_cardiac_valve_regurgitation1.97349719
22MP0002272_abnormal_nervous_system1.90010156
23MP0000733_abnormal_muscle_development1.88603993
24MP0000920_abnormal_myelination1.88173620
25MP0009745_abnormal_behavioral_response1.86995807
26MP0002572_abnormal_emotion/affect_behav1.82990587
27MP0003385_abnormal_body_wall1.79287569
28MP0001502_abnormal_circadian_rhythm1.76241299
29MP0000579_abnormal_nail_morphology1.75999511
30MP0000751_myopathy1.73358934
31MP0003091_abnormal_cell_migration1.72852554
32MP0005171_absent_coat_pigmentation1.72439808
33MP0000534_abnormal_ureter_morphology1.70251334
34MP0005508_abnormal_skeleton_morphology1.68191910
35MP0000428_abnormal_craniofacial_morphol1.66207332
36MP0001968_abnormal_touch/_nociception1.65236022
37MP0001984_abnormal_olfaction1.64262627
38MP0009250_abnormal_appendicular_skeleto1.63719252
39MP0000569_abnormal_digit_pigmentation1.63158018
40MP0002736_abnormal_nociception_after1.62429669
41MP0002089_abnormal_postnatal_growth/wei1.60135269
42MP0005076_abnormal_cell_differentiation1.57995520
43MP0002108_abnormal_muscle_morphology1.55478120
44MP0003942_abnormal_urinary_system1.54100262
45MP0002735_abnormal_chemical_nociception1.52320482
46MP0001970_abnormal_pain_threshold1.50314918
47MP0005257_abnormal_intraocular_pressure1.46833461
48MP0002896_abnormal_bone_mineralization1.44389969
49MP0004233_abnormal_muscle_weight1.44213781
50MP0003115_abnormal_respiratory_system1.43027155
51MP0002733_abnormal_thermal_nociception1.38461953
52MP0000778_abnormal_nervous_system1.37684715
53MP0005409_darkened_coat_color1.36486707
54MP0002249_abnormal_larynx_morphology1.35989045
55MP0000537_abnormal_urethra_morphology1.30815847
56MP0003136_yellow_coat_color1.26596262
57MP0003633_abnormal_nervous_system1.26456706
58MP0002557_abnormal_social/conspecific_i1.25155711
59MP0006054_spinal_hemorrhage1.24696123
60MP0002932_abnormal_joint_morphology1.22310683
61MP0003566_abnormal_cell_adhesion1.22214000
62MP0003879_abnormal_hair_cell1.21765874
63MP0003635_abnormal_synaptic_transmissio1.20601051
64MP0009046_muscle_twitch1.19821817
65MP0002882_abnormal_neuron_morphology1.19534173
66MP0003300_gastrointestinal_ulcer1.19354147
67MP0004134_abnormal_chest_morphology1.19341531
68MP0000013_abnormal_adipose_tissue1.18418164
69MP0003755_abnormal_palate_morphology1.18018602
70MP0010352_gastrointestinal_tract_polyps1.16844948
71MP0000049_abnormal_middle_ear1.16460172
72MP0002067_abnormal_sensory_capabilities1.16070795
73MP0009053_abnormal_anal_canal1.15977616
74MP0005167_abnormal_blood-brain_barrier1.15916955
75MP0001849_ear_inflammation1.15614683
76MP0003045_fibrosis1.14383416
77MP0003632_abnormal_nervous_system1.13211262
78MP0003631_nervous_system_phenotype1.08723370
79MP0001905_abnormal_dopamine_level1.07888757
80MP0002066_abnormal_motor_capabilities/c1.07426986
81MP0009379_abnormal_foot_pigmentation1.07379620
82MP0002116_abnormal_craniofacial_bone1.06995667
83MP0003935_abnormal_craniofacial_develop1.05769914
84MP0002234_abnormal_pharynx_morphology1.05405934
85MP0002295_abnormal_pulmonary_circulatio1.04916623
86MP0000762_abnormal_tongue_morphology1.04771606
87MP0002282_abnormal_trachea_morphology1.04003557
88MP0001348_abnormal_lacrimal_gland1.03618678
89MP0002060_abnormal_skin_morphology1.03470227
90MP0001177_atelectasis1.03092575
91MP0000604_amyloidosis1.02884562
92MP0005646_abnormal_pituitary_gland1.00510527
93MP0003634_abnormal_glial_cell0.99722072
94MP0001440_abnormal_grooming_behavior0.99494924
95MP0003329_amyloid_beta_deposits0.99407041
96MP0000163_abnormal_cartilage_morphology0.98959843
97MP0002233_abnormal_nose_morphology0.98657652
98MP0001501_abnormal_sleep_pattern0.97070101
99MP0005595_abnormal_vascular_smooth0.96959533
100MP0004087_abnormal_muscle_fiber0.95975612
101MP0003122_maternal_imprinting0.95749300
102MP0000003_abnormal_adipose_tissue0.94377841
103MP0004885_abnormal_endolymph0.93417731
104MP0005248_abnormal_Harderian_gland0.93347449
105MP0000432_abnormal_head_morphology0.92597928
106MP0000767_abnormal_smooth_muscle0.91622938
107MP0005187_abnormal_penis_morphology0.91183717
108MP0002115_abnormal_skeleton_extremities0.89624419
109MP0010368_abnormal_lymphatic_system0.88307969
110MP0002653_abnormal_ependyma_morphology0.88295100
111MP0002063_abnormal_learning/memory/cond0.87221454
112MP0001963_abnormal_hearing_physiology0.87067037
113MP0000955_abnormal_spinal_cord0.85919764
114MP0000759_abnormal_skeletal_muscle0.85897690
115MP0000750_abnormal_muscle_regeneration0.85770164
116MP0008569_lethality_at_weaning0.85769508
117MP0004270_analgesia0.84881341
118MP0002168_other_aberrant_phenotype0.84769132
119MP0006276_abnormal_autonomic_nervous0.83379033
120MP0003861_abnormal_nervous_system0.83160233
121MP0002697_abnormal_eye_size0.82431581
122MP0000026_abnormal_inner_ear0.82225301
123MP0004130_abnormal_muscle_cell0.80405982
124MP0002877_abnormal_melanocyte_morpholog0.79915048
125MP0003937_abnormal_limbs/digits/tail_de0.78946916
126MP0000462_abnormal_digestive_system0.78808858
127MP0002184_abnormal_innervation0.76806468
128MP0002152_abnormal_brain_morphology0.76570436
129MP0005023_abnormal_wound_healing0.75941462
130MP0004811_abnormal_neuron_physiology0.75743334
131MP0002133_abnormal_respiratory_system0.75044126
132MP0005388_respiratory_system_phenotype0.75044126
133MP0003075_altered_response_to0.74570313
134MP0002822_catalepsy0.74205742
135MP0002925_abnormal_cardiovascular_devel0.73856840
136MP0002114_abnormal_axial_skeleton0.73726746
137MP0002109_abnormal_limb_morphology0.73219574
138MP0009278_abnormal_bone_marrow0.73154389
139MP0004197_abnormal_fetal_growth/weight/0.73070350
140MP0002111_abnormal_tail_morphology0.71929538
141MP0002113_abnormal_skeleton_development0.71018545
142MP0002909_abnormal_adrenal_gland0.70593856
143MP0004084_abnormal_cardiac_muscle0.70581542
144MP0004145_abnormal_muscle_electrophysio0.69904383
145MP0002128_abnormal_blood_circulation0.69721136
146MP0006138_congestive_heart_failure0.69262913
147MP0001915_intracranial_hemorrhage0.68858362
148MP0002081_perinatal_lethality0.66479216

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.75858356
2Shallow orbits (HP:0000586)5.04310665
3Premature rupture of membranes (HP:0001788)4.96681994
4Ankle contracture (HP:0006466)4.23005208
5Broad metatarsal (HP:0001783)4.10585108
6Neurofibrillary tangles (HP:0002185)4.00917073
7Obstructive sleep apnea (HP:0002870)3.98013624
8Myokymia (HP:0002411)3.70437494
9Bladder diverticulum (HP:0000015)3.40821984
10Cerebral aneurysm (HP:0004944)3.37451971
11Diplopia (HP:0000651)3.25273726
12Abnormality of binocular vision (HP:0011514)3.25273726
13Focal motor seizures (HP:0011153)3.21164464
14Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.14473908
15Short 4th metacarpal (HP:0010044)3.14473908
16Cerebral inclusion bodies (HP:0100314)3.05885284
17Supranuclear gaze palsy (HP:0000605)3.00337288
18Aortic dissection (HP:0002647)2.98549562
19Peripheral hypomyelination (HP:0007182)2.89727998
20Abnormality of the 4th metacarpal (HP:0010012)2.85649381
21Genu recurvatum (HP:0002816)2.82400616
22Dilatation of the ascending aorta (HP:0005111)2.82224256
23Focal seizures (HP:0007359)2.79509225
24Bowel diverticulosis (HP:0005222)2.78865032
25Megalencephaly (HP:0001355)2.72827069
26Atrophic scars (HP:0001075)2.71978349
27Type 1 muscle fiber predominance (HP:0003803)2.68708647
28Neonatal short-limb short stature (HP:0008921)2.61922157
29Deviation of the hallux (HP:0010051)2.61125402
30Abnormality of dentin (HP:0010299)2.56914815
31Mitral valve prolapse (HP:0001634)2.56847486
32Soft skin (HP:0000977)2.56207220
33Cervical subluxation (HP:0003308)2.55236085
34Increased variability in muscle fiber diameter (HP:0003557)2.53966011
35Peritonitis (HP:0002586)2.51474303
36Coronal craniosynostosis (HP:0004440)2.49748907
37Spinal rigidity (HP:0003306)2.48773132
38Torticollis (HP:0000473)2.48570992
39Hallux valgus (HP:0001822)2.48142473
40Fragile skin (HP:0001030)2.47588861
41Overgrowth (HP:0001548)2.46185711
42Buphthalmos (HP:0000557)2.44509928
43Follicular hyperkeratosis (HP:0007502)2.42590194
44Split foot (HP:0001839)2.37779627
45Aortic aneurysm (HP:0004942)2.37450608
46Hyperacusis (HP:0010780)2.36256176
47Hemiplegia (HP:0002301)2.35737512
48Abnormal eating behavior (HP:0100738)2.34223331
49Turricephaly (HP:0000262)2.33982561
50Wrist flexion contracture (HP:0001239)2.33499741
51Renal duplication (HP:0000075)2.32177126
52Ankle clonus (HP:0011448)2.31076741
53Mildly elevated creatine phosphokinase (HP:0008180)2.30663158
54Hyperextensible skin (HP:0000974)2.29987897
55Hemiparesis (HP:0001269)2.28557660
56Enlarged penis (HP:0000040)2.26577288
57Blue sclerae (HP:0000592)2.25056085
58Sleep apnea (HP:0010535)2.22687359
59Broad ribs (HP:0000885)2.15629083
60Wormian bones (HP:0002645)2.15623071
61Renovascular hypertension (HP:0100817)2.14812667
62Flat cornea (HP:0007720)2.14615638
63Abnormality of skeletal muscle fiber size (HP:0012084)2.13066291
64Aplasia involving bones of the upper limbs (HP:0009823)2.11494160
65Aplasia of the phalanges of the hand (HP:0009802)2.11494160
66Aplasia involving bones of the extremities (HP:0009825)2.11494160
67Intention tremor (HP:0002080)2.11217863
68Mild short stature (HP:0003502)2.08186289
69Slender build (HP:0001533)2.06939657
70Vascular tortuosity (HP:0004948)2.06557850
71Truncal ataxia (HP:0002078)2.06228375
72Generalized tonic-clonic seizures (HP:0002069)2.04241555
73Hypoplasia of the iris (HP:0007676)2.03826533
74Atonic seizures (HP:0010819)2.03130550
75Aneurysm (HP:0002617)2.02038833
76Increased connective tissue (HP:0009025)1.99321501
77Distal upper limb amyotrophy (HP:0007149)1.97683583
78Upper limb amyotrophy (HP:0009129)1.97683583
79Wide anterior fontanel (HP:0000260)1.97536220
80Epileptic encephalopathy (HP:0200134)1.96285267
81Elfin facies (HP:0004428)1.96234775
82Joint laxity (HP:0001388)1.95464608
83Insomnia (HP:0100785)1.94096298
84Biconcave vertebral bodies (HP:0004586)1.91544704
85Mitral regurgitation (HP:0001653)1.89297053
86Overriding aorta (HP:0002623)1.88068288
87Thin bony cortex (HP:0002753)1.87744449
88Increased circulating renin level (HP:0000848)1.87534717
89Lymphangioma (HP:0100764)1.86006609
90Congenital glaucoma (HP:0001087)1.85830591
91Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.85484042
92Annular pancreas (HP:0001734)1.85302183
93Infantile muscular hypotonia (HP:0008947)1.85241344
94Asymmetry of the thorax (HP:0001555)1.84982187
95Bronchomalacia (HP:0002780)1.84939132
96Akinesia (HP:0002304)1.83397894
97Arterial tortuosity (HP:0005116)1.83270400
98Broad long bones (HP:0005622)1.82513484
99Macroorchidism (HP:0000053)1.81772275
100Pointed chin (HP:0000307)1.80223851
101Hypoventilation (HP:0002791)1.79625572
102Spastic gait (HP:0002064)1.78989719
103Scapular winging (HP:0003691)1.78841110
104Vertebral compression fractures (HP:0002953)1.77232401
105Hammertoe (HP:0001765)1.76755128
106Focal dystonia (HP:0004373)1.76468921
107Bell-shaped thorax (HP:0001591)1.76201697
108Febrile seizures (HP:0002373)1.75519491
109Dysmetria (HP:0001310)1.75196183
110Megalocornea (HP:0000485)1.74877918
111Craniofacial dystonia (HP:0012179)1.74596821
112Action tremor (HP:0002345)1.74304518
113Camptodactyly of toe (HP:0001836)1.74233815
114Papilledema (HP:0001085)1.74003263
115Ulnar bowing (HP:0003031)1.73394274
116Narrow nasal bridge (HP:0000446)1.73380665
117Striae distensae (HP:0001065)1.71301829
118Anomalous pulmonary venous return (HP:0010772)1.71043419
119Trigonocephaly (HP:0000243)1.70969460
120Spinal cord lesions (HP:0100561)1.68312756
121Syringomyelia (HP:0003396)1.68312756
122Elbow flexion contracture (HP:0002987)1.67662022
123Arnold-Chiari malformation (HP:0002308)1.66929563
124Hand muscle atrophy (HP:0009130)1.65668343
125Hyperparathyroidism (HP:0000843)1.65618175
126Abnormality of the pulmonary veins (HP:0011718)1.64217453
127Dysdiadochokinesis (HP:0002075)1.63708780
128Subacute progressive viral hepatitis (HP:0006572)1.61748345
129Venous abnormality (HP:0002624)1.61625471
130Vertebral arch anomaly (HP:0008438)1.61222640
131Difficulty running (HP:0009046)1.61117831
132Lower limb amyotrophy (HP:0007210)1.60620914
133Limb-girdle muscle weakness (HP:0003325)1.60436515
134Long toe (HP:0010511)1.60425442
135Protruding ear (HP:0000411)1.59585635
136Tarsal synostosis (HP:0008368)1.59439970
137Limb dystonia (HP:0002451)1.59192865
138Heterochromia iridis (HP:0001100)1.59034810
139Abnormality of the lower motor neuron (HP:0002366)1.58967138
140Scanning speech (HP:0002168)1.58728014
141Exostoses (HP:0100777)1.58178879
142Pectus excavatum (HP:0000767)1.58062904
143Abnormality of the diencephalon (HP:0010662)1.57888097
144Inguinal hernia (HP:0000023)1.56630315
145Broad phalanx (HP:0006009)1.55960397
146Venous insufficiency (HP:0005293)1.55663109

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.52665499
2DDR23.33223573
3PDGFRA3.12639975
4SIK12.78521987
5PKN22.74003525
6RIPK12.57409752
7CASK2.33583316
8PRKD32.28639935
9LATS22.27152456
10LATS12.15001926
11TTN2.10222434
12PAK62.10088651
13MARK12.08815945
14LMTK22.06964542
15EEF2K1.90540831
16TYRO31.88354075
17NTRK21.75826234
18EPHB21.73527459
19BMX1.69822773
20CAMKK11.58385177
21PTK61.49606723
22ICK1.48962238
23DMPK1.45047582
24PHKG21.42909474
25PHKG11.42909474
26NTRK11.41587929
27PAK31.34650121
28CAMK2B1.32773135
29PKN11.32513207
30SGK2231.31526172
31SGK4941.31526172
32ARAF1.28303174
33CAMK2G1.26923342
34PDGFRB1.25906077
35KSR11.25082426
36FGFR21.21986977
37FGFR11.20716648
38PAK21.20667472
39PTK21.20171556
40RET1.17367684
41CAMK1G1.17135888
42FER1.16440538
43NTRK31.15976023
44ERN11.15463815
45PRKCH1.10975025
46NEK61.10617692
47MAP3K101.09963319
48ILK1.09368221
49KSR21.05983292
50CAMK1D1.05378815
51ROCK21.04948734
52MAP3K91.03951817
53ROCK11.03624767
54SCYL21.02116748
55MOS1.01217206
56MTOR0.97847574
57SGK20.96574055
58MINK10.94960936
59PAK40.94175700
60DYRK1B0.89826765
61LRRK20.88352391
62CAMK2D0.88186927
63EPHA30.84939524
64CDK150.83558223
65EPHA40.82917837
66STK380.82756504
67CDK140.82522143
68ALK0.80088149
69CDK180.79056649
70CAMK2A0.78003456
71ERBB20.77554799
72GRK50.77373378
73PNCK0.76588632
74LIMK10.76430101
75TAOK10.75920761
76CAMK10.74022654
77MAPK100.72526814
78DYRK1A0.72469668
79CDK11A0.71440883
80NEK10.70442562
81PLK20.70328499
82SIK20.68023606
83CDK50.67576727
84CDK60.67110915
85MAPK120.66701473
86TESK10.65797511
87PRPF4B0.64916393
88EPHB10.63347479
89PTK2B0.62947566
90DAPK20.61848502
91CDC42BPA0.60240075
92MARK20.59461560
93SGK10.58545622
94CAMKK20.57888752
95MAP3K40.57775464
96ERBB30.57397772
97FGFR30.56153061
98MAP2K10.55799684
99TNK20.53982476
100MAPKAPK50.53609465
101PRKD10.53300055
102SRC0.52756975
103ERBB40.52749830
104PRKD20.49020163
105PINK10.48556134
106CDK120.47992474
107ABL20.47869826
108FES0.46110386
109MAPK70.45353031
110SGK30.42205686
111STK110.41007972
112MAP3K70.40279260
113MAPK40.39923338
114PRKCG0.39534931
115RPS6KA30.38999375
116RPS6KA20.38206853
117WNK10.38163559
118TNIK0.38001547
119INSR0.37085573
120FGFR40.37053539
121CSNK1G20.36676282
122PIK3CA0.36572505
123BRSK10.36377076
124STK30.36171962
125DYRK20.35845474
126MAP3K20.35369112
127UHMK10.35258089
128FYN0.35124748
129MET0.34946804
130MAPK130.34003571
131MYLK0.33866326

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.06776014
2Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.96228147
3Focal adhesion_Homo sapiens_hsa045101.87465256
4Nitrogen metabolism_Homo sapiens_hsa009101.87235567
5Glioma_Homo sapiens_hsa052141.75341035
6Basal cell carcinoma_Homo sapiens_hsa052171.71761841
7Proteoglycans in cancer_Homo sapiens_hsa052051.69812151
8Dilated cardiomyopathy_Homo sapiens_hsa054141.57303958
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.56941885
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.56492996
11Prion diseases_Homo sapiens_hsa050201.55275096
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.55112561
13Axon guidance_Homo sapiens_hsa043601.53973862
14Hippo signaling pathway_Homo sapiens_hsa043901.50209811
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.48320983
16Hedgehog signaling pathway_Homo sapiens_hsa043401.43188284
17Bladder cancer_Homo sapiens_hsa052191.39304176
18Adherens junction_Homo sapiens_hsa045201.36710714
19Chronic myeloid leukemia_Homo sapiens_hsa052201.35274112
20Endometrial cancer_Homo sapiens_hsa052131.33145855
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.31754577
22Gap junction_Homo sapiens_hsa045401.31743625
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.31042993
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30590106
25Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.28687665
26Estrogen signaling pathway_Homo sapiens_hsa049151.28346736
27Melanogenesis_Homo sapiens_hsa049161.28283170
28Circadian entrainment_Homo sapiens_hsa047131.26526098
29Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.25759483
30MicroRNAs in cancer_Homo sapiens_hsa052061.22098990
31Bile secretion_Homo sapiens_hsa049761.21298206
32Amoebiasis_Homo sapiens_hsa051461.18932837
33Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.16814399
34Gastric acid secretion_Homo sapiens_hsa049711.16022281
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.15921938
36mTOR signaling pathway_Homo sapiens_hsa041501.15315397
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14971040
38Colorectal cancer_Homo sapiens_hsa052101.13098321
39Thyroid hormone signaling pathway_Homo sapiens_hsa049191.12627095
40Glutamatergic synapse_Homo sapiens_hsa047241.12019263
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10917860
42GnRH signaling pathway_Homo sapiens_hsa049121.10291082
43Wnt signaling pathway_Homo sapiens_hsa043101.09369127
44Melanoma_Homo sapiens_hsa052181.08549456
45Long-term potentiation_Homo sapiens_hsa047201.07972405
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.07077751
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.05758139
48Oxytocin signaling pathway_Homo sapiens_hsa049211.05557953
49Fatty acid biosynthesis_Homo sapiens_hsa000611.05140871
50Cholinergic synapse_Homo sapiens_hsa047251.04831843
51Salivary secretion_Homo sapiens_hsa049701.03268626
52GABAergic synapse_Homo sapiens_hsa047271.03160912
53Protein digestion and absorption_Homo sapiens_hsa049741.02240354
54Central carbon metabolism in cancer_Homo sapiens_hsa052301.01887845
55ErbB signaling pathway_Homo sapiens_hsa040121.01579030
56Renal cell carcinoma_Homo sapiens_hsa052111.00647633
57Small cell lung cancer_Homo sapiens_hsa052220.99868273
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98132319
59Viral myocarditis_Homo sapiens_hsa054160.98039073
60Insulin secretion_Homo sapiens_hsa049110.97948557
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.97840678
62Pancreatic cancer_Homo sapiens_hsa052120.97432552
63Dopaminergic synapse_Homo sapiens_hsa047280.97132989
64Renin secretion_Homo sapiens_hsa049240.96761675
65Rap1 signaling pathway_Homo sapiens_hsa040150.95183321
66Dorso-ventral axis formation_Homo sapiens_hsa043200.93876143
67Non-small cell lung cancer_Homo sapiens_hsa052230.93463801
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92214210
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92075738
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91942262
71Cocaine addiction_Homo sapiens_hsa050300.91297448
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.91194283
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90923152
74Notch signaling pathway_Homo sapiens_hsa043300.90724719
75Vibrio cholerae infection_Homo sapiens_hsa051100.90127746
76Pancreatic secretion_Homo sapiens_hsa049720.89750355
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89704935
78Tight junction_Homo sapiens_hsa045300.89453348
79Long-term depression_Homo sapiens_hsa047300.88738339
80Olfactory transduction_Homo sapiens_hsa047400.87778999
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.87563332
82Type II diabetes mellitus_Homo sapiens_hsa049300.87300262
83Vitamin B6 metabolism_Homo sapiens_hsa007500.85923117
84TGF-beta signaling pathway_Homo sapiens_hsa043500.85487243
85Amphetamine addiction_Homo sapiens_hsa050310.83739547
86Synaptic vesicle cycle_Homo sapiens_hsa047210.82540046
87cAMP signaling pathway_Homo sapiens_hsa040240.82226904
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81023310
89VEGF signaling pathway_Homo sapiens_hsa043700.80670248
90Insulin signaling pathway_Homo sapiens_hsa049100.80013607
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.79953712
92AMPK signaling pathway_Homo sapiens_hsa041520.78654795
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78514616
94Nicotine addiction_Homo sapiens_hsa050330.77700856
95Prostate cancer_Homo sapiens_hsa052150.75897593
96Morphine addiction_Homo sapiens_hsa050320.75846480
97Pathways in cancer_Homo sapiens_hsa052000.75682452
98Taste transduction_Homo sapiens_hsa047420.74677848
99Serotonergic synapse_Homo sapiens_hsa047260.73890826
100Insulin resistance_Homo sapiens_hsa049310.72261006
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67528840
102Thyroid hormone synthesis_Homo sapiens_hsa049180.67067378
103Endocytosis_Homo sapiens_hsa041440.65383722
104Platelet activation_Homo sapiens_hsa046110.65069006
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63581668
106Choline metabolism in cancer_Homo sapiens_hsa052310.62726147
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62422980
108Glucagon signaling pathway_Homo sapiens_hsa049220.62197241
109MAPK signaling pathway_Homo sapiens_hsa040100.60787708
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60712736
111Calcium signaling pathway_Homo sapiens_hsa040200.59804578
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.58996321
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.57796438
114Ras signaling pathway_Homo sapiens_hsa040140.57742465
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54427578
116Inositol phosphate metabolism_Homo sapiens_hsa005620.53886285
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.51606097
118Cardiac muscle contraction_Homo sapiens_hsa042600.51099742
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47783690
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42713954

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