PCDHGC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.44883725
2postsynaptic membrane organization (GO:0001941)5.70339253
3neuron cell-cell adhesion (GO:0007158)5.55373535
4synaptic vesicle docking involved in exocytosis (GO:0016081)5.53354529
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.47007217
6synaptic vesicle exocytosis (GO:0016079)5.26963162
7glutamate secretion (GO:0014047)5.25661102
8vocalization behavior (GO:0071625)5.25306087
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.17906423
10presynaptic membrane assembly (GO:0097105)5.11383392
11regulation of synaptic vesicle exocytosis (GO:2000300)5.10006604
12ionotropic glutamate receptor signaling pathway (GO:0035235)5.05995360
13locomotory exploration behavior (GO:0035641)5.00238035
14presynaptic membrane organization (GO:0097090)4.78984396
15pyrimidine nucleobase catabolic process (GO:0006208)4.75724991
16cellular potassium ion homeostasis (GO:0030007)4.67315577
17membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.58495919
18protein localization to synapse (GO:0035418)4.56283758
19neurotransmitter secretion (GO:0007269)4.53493628
20exploration behavior (GO:0035640)4.52199805
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.44185697
22positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.38999324
23neurotransmitter-gated ion channel clustering (GO:0072578)4.35355660
24regulation of synaptic vesicle transport (GO:1902803)4.35324170
25sodium ion export (GO:0071436)4.34102725
26gamma-aminobutyric acid transport (GO:0015812)4.33820699
27auditory behavior (GO:0031223)4.25830991
28establishment of mitochondrion localization (GO:0051654)4.20749403
29synaptic transmission, glutamatergic (GO:0035249)4.20238036
30negative regulation of synaptic transmission, GABAergic (GO:0032229)4.12951896
31glutamate receptor signaling pathway (GO:0007215)4.11126808
32layer formation in cerebral cortex (GO:0021819)4.10910168
33neuronal action potential propagation (GO:0019227)4.08160006
34regulation of synapse structural plasticity (GO:0051823)3.97811866
35cerebellar granule cell differentiation (GO:0021707)3.94728066
36regulation of neuronal synaptic plasticity (GO:0048168)3.93915271
37regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.91256210
38positive regulation of synapse maturation (GO:0090129)3.88875853
39neuron recognition (GO:0008038)3.87859947
40nucleobase catabolic process (GO:0046113)3.83663035
41axonal fasciculation (GO:0007413)3.83187574
42regulation of glutamate receptor signaling pathway (GO:1900449)3.80770157
43neuronal ion channel clustering (GO:0045161)3.78293791
44amino acid import (GO:0043090)3.74618552
45neuron-neuron synaptic transmission (GO:0007270)3.73040102
46L-amino acid import (GO:0043092)3.70648611
47neurotransmitter transport (GO:0006836)3.69051799
48mitochondrion transport along microtubule (GO:0047497)3.65006356
49establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.65006356
50cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.64448672
51dendritic spine morphogenesis (GO:0060997)3.61247589
52regulation of long-term neuronal synaptic plasticity (GO:0048169)3.59513629
53cell migration in hindbrain (GO:0021535)3.57258611
54response to auditory stimulus (GO:0010996)3.49787844
55regulation of excitatory postsynaptic membrane potential (GO:0060079)3.49623787
56cell communication by electrical coupling (GO:0010644)3.49141927
57regulation of vesicle fusion (GO:0031338)3.47741034
58positive regulation of membrane potential (GO:0045838)3.47555552
59regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.44794217
60regulation of dendritic spine morphogenesis (GO:0061001)3.38444710
61regulation of neurotransmitter levels (GO:0001505)3.37412720
62mechanosensory behavior (GO:0007638)3.37388941
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.35537542
64transmission of nerve impulse (GO:0019226)3.31918361
65regulation of postsynaptic membrane potential (GO:0060078)3.31275581
66gamma-aminobutyric acid signaling pathway (GO:0007214)3.31058987
67positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.30325837
68synapse assembly (GO:0007416)3.26397314
69neuromuscular process controlling balance (GO:0050885)3.26041496
70regulation of synaptic transmission, glutamatergic (GO:0051966)3.23990476
71potassium ion homeostasis (GO:0055075)3.23016680
72positive regulation of synapse assembly (GO:0051965)3.19914364
73regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.19497667
74regulation of neurotransmitter secretion (GO:0046928)3.19346644
75synaptic vesicle endocytosis (GO:0048488)3.18110486
76dendrite morphogenesis (GO:0048813)3.16112713
77long-term memory (GO:0007616)3.13679727
78positive regulation of dendritic spine morphogenesis (GO:0061003)3.12245891
79potassium ion import (GO:0010107)3.11307917
80negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.07994202
81regulation of synaptic plasticity (GO:0048167)3.06816333
82central nervous system projection neuron axonogenesis (GO:0021952)3.06112707
83startle response (GO:0001964)3.05497702
84membrane assembly (GO:0071709)3.03809240
85regulation of synapse maturation (GO:0090128)3.03185632
86positive regulation of dendritic spine development (GO:0060999)3.02949179
87acidic amino acid transport (GO:0015800)3.01335862
88regulation of dendritic spine development (GO:0060998)2.96720108
89neuromuscular synaptic transmission (GO:0007274)2.94542670
90membrane depolarization during action potential (GO:0086010)2.94133230
91membrane depolarization (GO:0051899)2.93895980
92regulation of neurotransmitter transport (GO:0051588)2.92485295
93positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.91831706
94cellular sodium ion homeostasis (GO:0006883)2.91316199
95central nervous system myelination (GO:0022010)2.88320306
96axon ensheathment in central nervous system (GO:0032291)2.88320306
97synapse organization (GO:0050808)2.87858460
98cell communication involved in cardiac conduction (GO:0086065)2.86236224
99regulation of voltage-gated calcium channel activity (GO:1901385)2.83809275
100membrane hyperpolarization (GO:0060081)2.83622730

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.44142537
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.50043929
3GBX2_23144817_ChIP-Seq_PC3_Human3.33218361
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.90527017
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.78269121
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77414357
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.71788824
8REST_21632747_ChIP-Seq_MESCs_Mouse2.70851871
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.63414053
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.54903121
11DROSHA_22980978_ChIP-Seq_HELA_Human2.48270028
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47330853
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47330853
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45758100
15* EED_16625203_ChIP-ChIP_MESCs_Mouse2.43975661
16* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43159235
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40097982
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29241509
19* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.27406992
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.26383620
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.25644061
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21506285
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17314267
24* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.16421175
25RARB_27405468_Chip-Seq_BRAIN_Mouse2.11558173
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.10382111
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.88091398
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82424031
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82043641
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79613836
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.78177581
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76109631
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75944084
34* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63305723
35AR_21572438_ChIP-Seq_LNCaP_Human1.59755541
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54825231
37SMAD4_21799915_ChIP-Seq_A2780_Human1.54390320
38RNF2_27304074_Chip-Seq_NSC_Mouse1.53828306
39TAF15_26573619_Chip-Seq_HEK293_Human1.53492662
40* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51372455
41RING1B_27294783_Chip-Seq_ESCs_Mouse1.44158783
42RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.43928081
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40903881
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40775244
45RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.40466066
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39338231
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.37886220
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36521164
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33307835
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32758038
51YAP1_20516196_ChIP-Seq_MESCs_Mouse1.30770963
52SOX2_21211035_ChIP-Seq_LN229_Gbm1.27556592
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27337051
54TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27305571
55POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27305571
56* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25925567
57TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25874593
58AR_19668381_ChIP-Seq_PC3_Human1.24676625
59P300_19829295_ChIP-Seq_ESCs_Human1.23544905
60WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22626530
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20696576
62RING1B_27294783_Chip-Seq_NPCs_Mouse1.20045683
63EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19170207
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18915994
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18608917
66IGF1R_20145208_ChIP-Seq_DFB_Human1.17032209
67STAT3_23295773_ChIP-Seq_U87_Human1.14999464
68MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14948201
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13357263
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12219060
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09857208
72SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07225190
73OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06602744
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04998698
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.04910507
76SOX9_26525672_Chip-Seq_HEART_Mouse1.04469712
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04405542
78LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04301465
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03996249
80ERG_21242973_ChIP-ChIP_JURKAT_Human1.02557821
81GATA1_26923725_Chip-Seq_HPCs_Mouse1.02343311
82FUS_26573619_Chip-Seq_HEK293_Human1.02065622
83CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01880228
84* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01762414
85TCF4_23295773_ChIP-Seq_U87_Human1.01427222
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99804313
87DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99793450
88RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98982382
89SMAD4_21741376_ChIP-Seq_HESCs_Human0.98850690
90SMAD3_21741376_ChIP-Seq_ESCs_Human0.97177793
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97137014
92KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95828266
93AR_25329375_ChIP-Seq_VCAP_Human0.94373295
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94329332
95STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93976532
96CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93678595
97* ISL1_27105846_Chip-Seq_CPCs_Mouse0.92596556
98TP53_18474530_ChIP-ChIP_U2OS_Human0.91466515
99P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91466125
100KDM2B_26808549_Chip-Seq_REH_Human0.88273932

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.80453876
2MP0004270_analgesia4.23964167
3MP0003880_abnormal_central_pattern3.97040317
4MP0005423_abnormal_somatic_nervous3.75839912
5MP0003635_abnormal_synaptic_transmissio3.61741778
6MP0002734_abnormal_mechanical_nocicepti2.88034627
7MP0002064_seizures2.86440214
8MP0002063_abnormal_learning/memory/cond2.85912205
9MP0001486_abnormal_startle_reflex2.85789406
10MP0002822_catalepsy2.80059713
11MP0009745_abnormal_behavioral_response2.77262262
12MP0002735_abnormal_chemical_nociception2.68884160
13MP0009046_muscle_twitch2.60863001
14MP0001968_abnormal_touch/_nociception2.58182947
15MP0002272_abnormal_nervous_system2.55075725
16MP0000778_abnormal_nervous_system2.50765698
17MP0002572_abnormal_emotion/affect_behav2.37374676
18MP0002736_abnormal_nociception_after2.23575815
19MP0001984_abnormal_olfaction2.10623496
20MP0003122_maternal_imprinting2.06999946
21MP0003329_amyloid_beta_deposits1.87365688
22MP0008569_lethality_at_weaning1.79994642
23MP0001970_abnormal_pain_threshold1.78232448
24MP0002733_abnormal_thermal_nociception1.77352231
25MP0002067_abnormal_sensory_capabilities1.74590054
26MP0001501_abnormal_sleep_pattern1.73126810
27MP0004811_abnormal_neuron_physiology1.72388633
28MP0002557_abnormal_social/conspecific_i1.70505831
29MP0000955_abnormal_spinal_cord1.69869351
30MP0002184_abnormal_innervation1.66156499
31MP0001529_abnormal_vocalization1.59899344
32MP0001502_abnormal_circadian_rhythm1.59603853
33MP0004885_abnormal_endolymph1.56741806
34MP0003787_abnormal_imprinting1.56283179
35MP0004924_abnormal_behavior1.55237277
36MP0005386_behavior/neurological_phenoty1.55237277
37MP0006276_abnormal_autonomic_nervous1.54690043
38MP0002882_abnormal_neuron_morphology1.52618638
39MP0001440_abnormal_grooming_behavior1.44538874
40MP0003879_abnormal_hair_cell1.42435270
41MP0001188_hyperpigmentation1.39939194
42MP0002066_abnormal_motor_capabilities/c1.36421339
43MP0005646_abnormal_pituitary_gland1.29840018
44MP0002152_abnormal_brain_morphology1.28952194
45MP0001177_atelectasis1.27425774
46MP0003690_abnormal_glial_cell1.22609041
47MP0000569_abnormal_digit_pigmentation1.19361590
48MP0003633_abnormal_nervous_system1.17680083
49MP0005645_abnormal_hypothalamus_physiol1.16194039
50MP0009780_abnormal_chondrocyte_physiolo1.15035092
51MP0004742_abnormal_vestibular_system1.14208035
52MP0003631_nervous_system_phenotype1.12994785
53MP0000920_abnormal_myelination1.11547238
54MP0005409_darkened_coat_color1.09267799
55MP0003634_abnormal_glial_cell1.08536326
56MP0003632_abnormal_nervous_system1.07209803
57MP0005623_abnormal_meninges_morphology1.06859752
58MP0002102_abnormal_ear_morphology1.03669211
59MP0001905_abnormal_dopamine_level1.01355563
60MP0010386_abnormal_urinary_bladder0.99770543
61MP0003121_genomic_imprinting0.99096401
62MP0003861_abnormal_nervous_system0.98746779
63MP0005187_abnormal_penis_morphology0.96339185
64MP0002638_abnormal_pupillary_reflex0.96085408
65MP0001963_abnormal_hearing_physiology0.95411198
66MP0001299_abnormal_eye_distance/0.93217378
67MP0002752_abnormal_somatic_nervous0.91441901
68MP0002653_abnormal_ependyma_morphology0.89349736
69MP0004142_abnormal_muscle_tone0.89020432
70MP0001348_abnormal_lacrimal_gland0.88819006
71MP0003283_abnormal_digestive_organ0.88338193
72MP0005499_abnormal_olfactory_system0.86540564
73MP0005394_taste/olfaction_phenotype0.86540564
74MP0002229_neurodegeneration0.84171636
75MP0002069_abnormal_eating/drinking_beha0.82994194
76MP0002249_abnormal_larynx_morphology0.82446700
77MP0000026_abnormal_inner_ear0.78589813
78MP0001485_abnormal_pinna_reflex0.77859993
79MP0002751_abnormal_autonomic_nervous0.75959258
80MP0005551_abnormal_eye_electrophysiolog0.75303675
81MP0002909_abnormal_adrenal_gland0.75156187
82MP0000534_abnormal_ureter_morphology0.74950063
83MP0000049_abnormal_middle_ear0.74427237
84MP0000579_abnormal_nail_morphology0.73857634
85MP0000751_myopathy0.73466313
86MP0000631_abnormal_neuroendocrine_gland0.72384523
87MP0002082_postnatal_lethality0.71612135
88MP0010770_preweaning_lethality0.71612135
89MP0010769_abnormal_survival0.71414682
90MP0002081_perinatal_lethality0.68037999
91MP0000604_amyloidosis0.67540836
92MP0010768_mortality/aging0.67271060
93MP0001943_abnormal_respiration0.66930450
94MP0003137_abnormal_impulse_conducting0.64177736
95MP0004147_increased_porphyrin_level0.62107670
96MP0003119_abnormal_digestive_system0.61784363
97MP0003938_abnormal_ear_development0.61227933
98MP0003123_paternal_imprinting0.56387771
99MP0001986_abnormal_taste_sensitivity0.52549819
100MP0001346_abnormal_lacrimal_gland0.52358424

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.26540807
2Focal motor seizures (HP:0011153)6.12182201
3Focal seizures (HP:0007359)4.99561584
4Epileptic encephalopathy (HP:0200134)4.30673962
5Action tremor (HP:0002345)4.21456381
6Atonic seizures (HP:0010819)4.17283489
7Febrile seizures (HP:0002373)4.08561116
8Ankle clonus (HP:0011448)3.52119732
9Limb dystonia (HP:0002451)3.50571697
10Progressive cerebellar ataxia (HP:0002073)3.49760421
11Supranuclear gaze palsy (HP:0000605)3.45203131
12Generalized tonic-clonic seizures (HP:0002069)3.29316002
13Drooling (HP:0002307)3.25865545
14Neurofibrillary tangles (HP:0002185)3.21083259
15Abnormality of binocular vision (HP:0011514)3.15300461
16Diplopia (HP:0000651)3.15300461
17Dialeptic seizures (HP:0011146)3.07817523
18Spastic gait (HP:0002064)3.04527241
19Excessive salivation (HP:0003781)2.98935973
20Amyotrophic lateral sclerosis (HP:0007354)2.92082382
21Mutism (HP:0002300)2.89452039
22Abnormal eating behavior (HP:0100738)2.84905840
23Postural instability (HP:0002172)2.81528811
24Hyperventilation (HP:0002883)2.81407920
25Truncal ataxia (HP:0002078)2.79913069
26Abnormality of the lower motor neuron (HP:0002366)2.79644940
27Epileptiform EEG discharges (HP:0011182)2.79603225
28Absence seizures (HP:0002121)2.75361739
29Abnormality of the corticospinal tract (HP:0002492)2.70574898
30Torticollis (HP:0000473)2.69147293
31Hemiparesis (HP:0001269)2.66605092
32Urinary urgency (HP:0000012)2.64791755
33Broad-based gait (HP:0002136)2.64296030
34Hemiplegia (HP:0002301)2.61807645
35EEG with generalized epileptiform discharges (HP:0011198)2.58548690
36Obstructive sleep apnea (HP:0002870)2.55067737
37Hypsarrhythmia (HP:0002521)2.50437796
38Peripheral hypomyelination (HP:0007182)2.50338199
39Sleep apnea (HP:0010535)2.47460893
40Papilledema (HP:0001085)2.45693188
41Cerebral inclusion bodies (HP:0100314)2.45642829
42Cortical dysplasia (HP:0002539)2.44655983
43Urinary bladder sphincter dysfunction (HP:0002839)2.43041619
44Dysmetria (HP:0001310)2.40436418
45Polyphagia (HP:0002591)2.37057901
46Impaired vibration sensation in the lower limbs (HP:0002166)2.36527953
47Akinesia (HP:0002304)2.34594211
48Megalencephaly (HP:0001355)2.34411732
49Poor eye contact (HP:0000817)2.30067373
50Genetic anticipation (HP:0003743)2.29331903
51Impaired social interactions (HP:0000735)2.28887442
52Abnormal social behavior (HP:0012433)2.28887442
53Failure to thrive in infancy (HP:0001531)2.28213749
54Hepatoblastoma (HP:0002884)2.27309763
55Insomnia (HP:0100785)2.27186254
56Absent speech (HP:0001344)2.24238520
57Split foot (HP:0001839)2.22414661
58Lower limb muscle weakness (HP:0007340)2.22071091
59Intention tremor (HP:0002080)2.21624486
60Amblyopia (HP:0000646)2.18927216
61Depression (HP:0000716)2.17472323
62Dysdiadochokinesis (HP:0002075)2.15726333
63Cerebral hypomyelination (HP:0006808)2.14195072
64Status epilepticus (HP:0002133)2.13857033
65Focal dystonia (HP:0004373)2.02919089
66Spastic tetraplegia (HP:0002510)2.01171567
67Neoplasm of the heart (HP:0100544)2.01064923
68Scanning speech (HP:0002168)2.01041410
69Bradykinesia (HP:0002067)1.97115125
70Morphological abnormality of the pyramidal tract (HP:0002062)1.96833564
71Turricephaly (HP:0000262)1.95911987
72Tetraplegia (HP:0002445)1.95217290
73Cutaneous finger syndactyly (HP:0010554)1.94621202
74Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.90072472
75Anxiety (HP:0000739)1.89298379
76Alacrima (HP:0000522)1.88980462
77Craniofacial dystonia (HP:0012179)1.88000134
78Impaired smooth pursuit (HP:0007772)1.87682070
79Esotropia (HP:0000565)1.87632996
80Apathy (HP:0000741)1.86730955
81Medulloblastoma (HP:0002885)1.86663933
82Hypoplasia of the corpus callosum (HP:0002079)1.86088612
83Pheochromocytoma (HP:0002666)1.84852211
84Abnormality of the labia minora (HP:0012880)1.82993309
85Hammertoe (HP:0001765)1.80495015
86Stereotypic behavior (HP:0000733)1.77694255
87Shallow orbits (HP:0000586)1.77264298
88Clonus (HP:0002169)1.76329222
89Choanal stenosis (HP:0000452)1.75614734
90Abnormality of ocular smooth pursuit (HP:0000617)1.74332208
91Hypoplasia of the brainstem (HP:0002365)1.72683031
92Aplasia/Hypoplasia of the brainstem (HP:0007362)1.72683031
93Visual hallucinations (HP:0002367)1.72453364
94Degeneration of the lateral corticospinal tracts (HP:0002314)1.70606394
95Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.70606394
96Specific learning disability (HP:0001328)1.70444482
97Cutaneous syndactyly (HP:0012725)1.69113922
98Spastic tetraparesis (HP:0001285)1.68213405
99Fetal akinesia sequence (HP:0001989)1.67868527
100Aplasia of the phalanges of the hand (HP:0009802)1.67802267

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.01281577
2CASK3.77139272
3EPHA43.46958797
4NTRK33.40362568
5NTRK23.00560013
6UHMK12.45246950
7NTRK12.41537973
8PINK12.36155600
9PAK62.31689831
10MINK12.17835362
11DAPK22.09507172
12PRKD32.05867550
13MAPK132.05719799
14MAP3K41.69444415
15SIK21.62218979
16BCR1.55423763
17CDK51.54488413
18MAP2K71.47784376
19LATS21.46143208
20TYRO31.44028285
21DYRK21.43716606
22MAP3K91.43427226
23CSNK1G21.43202205
24SGK4941.41082396
25SGK2231.41082396
26PLK21.39611482
27CAMKK11.35319144
28MAP4K21.34655000
29PRKCG1.24867710
30CAMK2B1.24718418
31PHKG11.24010995
32PHKG21.24010995
33CSNK1A1L1.20849873
34PKN11.20047086
35CAMK1G1.17870178
36RIPK11.16101581
37DYRK1A1.15704357
38CSNK1G31.14233465
39PNCK1.13415537
40EPHA31.09418199
41CDK181.07875552
42CDK151.07031639
43SGK21.06468746
44CDK140.98870844
45CSNK1G10.98607376
46CDK11A0.96772413
47CAMK2A0.95110503
48MAP2K40.93059215
49CAMKK20.92567218
50KSR10.90450911
51TNIK0.90037504
52CAMK10.89551979
53PAK30.88506088
54PRKCH0.87011457
55CCNB10.85364856
56CAMK1D0.84685203
57NEK60.83753420
58FGFR20.82402042
59CDK190.80507198
60TRIM280.74401896
61CAMK40.69915023
62RET0.67186734
63CAMK2G0.66387362
64MARK20.66031394
65BRD40.65695189
66DAPK10.63062259
67SGK10.62892365
68DDR20.60928480
69SGK30.60834604
70ROCK20.59824042
71STK110.59790734
72MAPK100.59699463
73PDGFRA0.58258842
74STK380.56626940
75PRKCE0.54799761
76PRKCZ0.54679953
77RPS6KA30.48646865
78TESK10.48180812
79CSNK1D0.46302758
80ERBB30.46284251
81INSRR0.46040726
82MAPK120.45984572
83ALK0.44320392
84WNK10.43503698
85CAMK2D0.43431015
86ICK0.42221624
87EPHB20.41358726
88ROCK10.39927992
89KSR20.38533183
90CSNK1A10.38488398
91GRK50.38213329
92PRKG10.36940648
93LIMK10.36629417
94WNK30.36463855
95BRSK10.36009279
96FYN0.35949228
97MAP3K120.35691665
98ERBB20.35195262
99MAPK80.35074796
100PRKAA10.34944390

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.61198063
2Synaptic vesicle cycle_Homo sapiens_hsa047213.39255087
3GABAergic synapse_Homo sapiens_hsa047273.06552337
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.80443830
5Glutamatergic synapse_Homo sapiens_hsa047242.75515780
6Circadian entrainment_Homo sapiens_hsa047132.71855151
7Morphine addiction_Homo sapiens_hsa050322.61386726
8Long-term potentiation_Homo sapiens_hsa047202.49424164
9Amphetamine addiction_Homo sapiens_hsa050312.44656334
10Dopaminergic synapse_Homo sapiens_hsa047282.18572920
11Cocaine addiction_Homo sapiens_hsa050302.17382774
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14662820
13Insulin secretion_Homo sapiens_hsa049112.11307200
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.98980298
15Gastric acid secretion_Homo sapiens_hsa049711.91515720
16Cholinergic synapse_Homo sapiens_hsa047251.74993497
17Taste transduction_Homo sapiens_hsa047421.70062613
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64474002
19Salivary secretion_Homo sapiens_hsa049701.63075793
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62808675
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53768845
22Axon guidance_Homo sapiens_hsa043601.51817491
23Renin secretion_Homo sapiens_hsa049241.47921316
24Gap junction_Homo sapiens_hsa045401.47873139
25Long-term depression_Homo sapiens_hsa047301.47333925
26cAMP signaling pathway_Homo sapiens_hsa040241.42805984
27Oxytocin signaling pathway_Homo sapiens_hsa049211.41321211
28Serotonergic synapse_Homo sapiens_hsa047261.34164651
29Calcium signaling pathway_Homo sapiens_hsa040201.29502619
30Estrogen signaling pathway_Homo sapiens_hsa049151.22193618
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21560185
32Melanogenesis_Homo sapiens_hsa049161.14557150
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08866457
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06018534
35cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04465955
36Vibrio cholerae infection_Homo sapiens_hsa051101.02723377
37Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.02551179
38Olfactory transduction_Homo sapiens_hsa047401.00475723
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99724753
40Oocyte meiosis_Homo sapiens_hsa041140.98528858
41Glioma_Homo sapiens_hsa052140.97896184
42GnRH signaling pathway_Homo sapiens_hsa049120.95407626
43Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93750981
44Phospholipase D signaling pathway_Homo sapiens_hsa040720.91184441
45ErbB signaling pathway_Homo sapiens_hsa040120.90926702
46Bile secretion_Homo sapiens_hsa049760.88225911
47Vitamin B6 metabolism_Homo sapiens_hsa007500.85576723
48Collecting duct acid secretion_Homo sapiens_hsa049660.85376031
49Type II diabetes mellitus_Homo sapiens_hsa049300.83289641
50Phototransduction_Homo sapiens_hsa047440.83268868
51Rap1 signaling pathway_Homo sapiens_hsa040150.82029149
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81705834
53Cardiac muscle contraction_Homo sapiens_hsa042600.81571349
54Thyroid hormone synthesis_Homo sapiens_hsa049180.79757567
55Dilated cardiomyopathy_Homo sapiens_hsa054140.79711481
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75427818
57Pancreatic secretion_Homo sapiens_hsa049720.74606807
58Hippo signaling pathway_Homo sapiens_hsa043900.73859140
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73748836
60Alcoholism_Homo sapiens_hsa050340.73224350
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70985339
62Wnt signaling pathway_Homo sapiens_hsa043100.70743412
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.69378285
64Circadian rhythm_Homo sapiens_hsa047100.68351025
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67225389
66Ras signaling pathway_Homo sapiens_hsa040140.65655513
67Hedgehog signaling pathway_Homo sapiens_hsa043400.64673839
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63756738
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60131931
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.59848811
71Choline metabolism in cancer_Homo sapiens_hsa052310.59003254
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58987655
73Glucagon signaling pathway_Homo sapiens_hsa049220.57101467
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55807500
75MAPK signaling pathway_Homo sapiens_hsa040100.55047534
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52423985
77Tight junction_Homo sapiens_hsa045300.52173179
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50920860
79AMPK signaling pathway_Homo sapiens_hsa041520.49620638
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49033090
81Prion diseases_Homo sapiens_hsa050200.47370824
82Inositol phosphate metabolism_Homo sapiens_hsa005620.46216947
83Dorso-ventral axis formation_Homo sapiens_hsa043200.46045108
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42766212
85Basal cell carcinoma_Homo sapiens_hsa052170.42284521
86Endometrial cancer_Homo sapiens_hsa052130.42215135
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42133930
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.38914191
89Fatty acid biosynthesis_Homo sapiens_hsa000610.38536717
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37015638
91Endocytosis_Homo sapiens_hsa041440.36888578
92Adherens junction_Homo sapiens_hsa045200.36604138
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36456709
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35645504
95Colorectal cancer_Homo sapiens_hsa052100.32482592
96mTOR signaling pathway_Homo sapiens_hsa041500.31418607
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30233569
98VEGF signaling pathway_Homo sapiens_hsa043700.30159649
99Protein digestion and absorption_Homo sapiens_hsa049740.28678192
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27723982

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »