PCED1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the GDSL/SGNH superfamily. Members of this family are hydrolytic enzymes with esterase and lipase activity and broad substrate specificity. This protein belongs to the Pmr5-Cas1p-esterase subfamily in that it contains the catalytic triad comprised of serine, aspartate and histidine and lacks two conserved regions (glycine after strand S2 and GxND motif). A pseudogene of this gene has been identified on the long arm of chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine metabolic process (GO:0006558)5.82682860
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.82682860
3L-phenylalanine catabolic process (GO:0006559)5.78418306
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.78418306
5negative regulation of erythrocyte differentiation (GO:0045647)5.77823627
6alpha-linolenic acid metabolic process (GO:0036109)5.06596575
7L-serine metabolic process (GO:0006563)4.66635108
8protein carboxylation (GO:0018214)4.56364218
9peptidyl-glutamic acid carboxylation (GO:0017187)4.56364218
10aromatic amino acid family catabolic process (GO:0009074)4.32321374
11serine family amino acid biosynthetic process (GO:0009070)4.10509578
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.09205935
13negative regulation of sterol transport (GO:0032372)3.91326051
14negative regulation of cholesterol transport (GO:0032375)3.91326051
15response to muramyl dipeptide (GO:0032495)3.83494262
16regulation of ARF GTPase activity (GO:0032312)3.81865223
17negative regulation of fibrinolysis (GO:0051918)3.80195302
18urea cycle (GO:0000050)3.78819936
19urea metabolic process (GO:0019627)3.78819936
20regulation of fibrinolysis (GO:0051917)3.69362275
21bile acid biosynthetic process (GO:0006699)3.68298660
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.59363860
23regulation of cholesterol homeostasis (GO:2000188)3.54715937
24sulfur amino acid catabolic process (GO:0000098)3.53818949
25plasma lipoprotein particle clearance (GO:0034381)3.51468605
26high-density lipoprotein particle remodeling (GO:0034375)3.50799658
27positive thymic T cell selection (GO:0045059)3.46813439
28cell-cell junction maintenance (GO:0045217)3.46362939
29positive regulation of fatty acid beta-oxidation (GO:0032000)3.43816337
30bile acid metabolic process (GO:0008206)3.36842119
31tyrosine metabolic process (GO:0006570)3.34669616
32complement activation, alternative pathway (GO:0006957)3.33231790
33killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.32395201
34disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.32395201
35lysine catabolic process (GO:0006554)3.31929129
36lysine metabolic process (GO:0006553)3.31929129
37kynurenine metabolic process (GO:0070189)3.31479080
38glyoxylate metabolic process (GO:0046487)3.28997107
39regulation of protein activation cascade (GO:2000257)3.26270861
40glycine metabolic process (GO:0006544)3.25002027
41positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.23242212
42dicarboxylic acid biosynthetic process (GO:0043650)3.23103559
43Golgi transport vesicle coating (GO:0048200)3.22556214
44COPI coating of Golgi vesicle (GO:0048205)3.22556214
45protein retention in ER lumen (GO:0006621)3.22067038
46nitrogen cycle metabolic process (GO:0071941)3.18624947
47antigen processing and presentation of endogenous antigen (GO:0019883)3.18526219
48tetrahydrofolate metabolic process (GO:0046653)3.18485067
49antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.17590649
50positive regulation of gamma-delta T cell activation (GO:0046645)3.13868608
51negative regulation of cell size (GO:0045792)3.13065989
52negative regulation of cell killing (GO:0031342)3.13043472
53negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.13043472
54positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.12527325
55regulation of ARF protein signal transduction (GO:0032012)3.10682305
56axon extension involved in axon guidance (GO:0048846)3.09117439
57neuron projection extension involved in neuron projection guidance (GO:1902284)3.09117439
58regulation of fatty acid beta-oxidation (GO:0031998)3.08635558
59cellular modified amino acid catabolic process (GO:0042219)3.08288225
60thymic T cell selection (GO:0045061)3.05985080
61regulation of extracellular matrix disassembly (GO:0010715)3.05735767
62mannose metabolic process (GO:0006013)3.01782836
63plasma lipoprotein particle remodeling (GO:0034369)3.01722206
64protein-lipid complex remodeling (GO:0034368)3.01722206
65macromolecular complex remodeling (GO:0034367)3.01722206
66regulation of complement activation (GO:0030449)3.01615230
67aromatic amino acid family metabolic process (GO:0009072)2.99291828
68tryptophan metabolic process (GO:0006568)2.98406395
69antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.97900641
704-hydroxyproline metabolic process (GO:0019471)2.97900556
71negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.96274330
72tryptophan catabolic process (GO:0006569)2.96147414
73indole-containing compound catabolic process (GO:0042436)2.96147414
74indolalkylamine catabolic process (GO:0046218)2.96147414
75glutamate metabolic process (GO:0006536)2.96140293
76histone H4 deacetylation (GO:0070933)2.95323434
77modulation by virus of host process (GO:0019054)2.94410282
78semaphorin-plexin signaling pathway (GO:0071526)2.94146425
79fatty acid elongation (GO:0030497)2.92907915
80positive regulation of histone deacetylation (GO:0031065)2.91381875
81aspartate family amino acid catabolic process (GO:0009068)2.91317156
82modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.90681418
83positive regulation by organism of defense response of other organism involved in symbiotic interact2.90681418
84modulation by symbiont of host immune response (GO:0052553)2.90681418
85positive regulation by symbiont of host defense response (GO:0052509)2.90681418
86modulation by symbiont of host defense response (GO:0052031)2.90681418
87modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.90681418
88acetyl-CoA metabolic process (GO:0006084)2.89966989
89activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.88856443
90maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.87232046
91reverse cholesterol transport (GO:0043691)2.86945074
92endothelial cell chemotaxis (GO:0035767)2.86463439
93positive regulation of lipid catabolic process (GO:0050996)2.85407741
94alpha-amino acid catabolic process (GO:1901606)2.84437281
95positive regulation of nuclease activity (GO:0032075)2.82868730
96proline biosynthetic process (GO:0006561)2.82834664
97response to methylmercury (GO:0051597)2.82728737
98modulation by symbiont of host cellular process (GO:0044068)2.82030418
99acylglycerol homeostasis (GO:0055090)2.81301560
100triglyceride homeostasis (GO:0070328)2.81301560
101glutamine family amino acid biosynthetic process (GO:0009084)2.80437884
102protein-lipid complex assembly (GO:0065005)2.80016579
103fatty-acyl-CoA biosynthetic process (GO:0046949)2.78076054
104regulation of monocyte differentiation (GO:0045655)2.78016870
105serine family amino acid metabolic process (GO:0009069)2.77081595
106phospholipid efflux (GO:0033700)2.76519253
107positive regulation of CREB transcription factor activity (GO:0032793)2.75123238
108coenzyme catabolic process (GO:0009109)2.74547005
109regulation of cholesterol esterification (GO:0010872)2.73806049
110positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.72884898
111plasma lipoprotein particle assembly (GO:0034377)2.72351646
112long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.72030118
113one-carbon metabolic process (GO:0006730)2.71668938
114phospholipid homeostasis (GO:0055091)2.71321534
115cholesterol efflux (GO:0033344)2.70972815
116response to peptidoglycan (GO:0032494)2.70517167
117regulation of triglyceride catabolic process (GO:0010896)2.65981515
118positive regulation of fatty acid biosynthetic process (GO:0045723)2.65974356
119apoptotic cell clearance (GO:0043277)2.65236646
120germinal center formation (GO:0002467)2.63665109
121negative regulation of lipase activity (GO:0060192)2.63411404
122activation of MAPKKK activity (GO:0000185)2.63268457
123folic acid-containing compound biosynthetic process (GO:0009396)2.63139449
124cellular amino acid catabolic process (GO:0009063)2.62869498
125cellular response to virus (GO:0098586)2.62609191
126macroautophagy (GO:0016236)2.61614099
127positive regulation of protein deacetylation (GO:0090312)2.60846903
128folic acid-containing compound metabolic process (GO:0006760)2.59971787
129very long-chain fatty acid metabolic process (GO:0000038)2.59326966
130astrocyte differentiation (GO:0048708)2.58378818
131complement activation, classical pathway (GO:0006958)2.57937852
132response to laminar fluid shear stress (GO:0034616)2.57853555
133low-density lipoprotein particle remodeling (GO:0034374)2.57173268
134positive regulation of gastrulation (GO:2000543)2.57011921
135detection of bacterium (GO:0016045)2.54990282
136negative regulation of granulocyte differentiation (GO:0030853)2.54169721
137negative regulation of cell cycle arrest (GO:0071157)2.53874480
138retrograde transport, endosome to Golgi (GO:0042147)2.53718016
139positive regulation of glycogen biosynthetic process (GO:0045725)2.53657720
140apoptotic process involved in morphogenesis (GO:0060561)2.53198568
141negative thymic T cell selection (GO:0045060)2.53151336
142activation of JUN kinase activity (GO:0007257)2.52317508
143regulation of mammary gland epithelial cell proliferation (GO:0033599)2.51354501
144mitochondrion transport along microtubule (GO:0047497)2.51290169
145establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.51290169
146cell junction maintenance (GO:0034331)2.51189817
147entrainment of circadian clock by photoperiod (GO:0043153)2.50295730
148negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.49302677
149positive regulation of Cdc42 GTPase activity (GO:0043089)2.48613317
150regulation of cholesterol metabolic process (GO:0090181)2.47293659
151regulation of extracellular matrix organization (GO:1903053)2.45103964
152NIK/NF-kappaB signaling (GO:0038061)2.44505855
153regulation of gamma-delta T cell activation (GO:0046643)2.44323760
154negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.44322625
155positive regulation of extracellular matrix organization (GO:1903055)2.44063835
156histone H3 deacetylation (GO:0070932)2.43530019
157maintenance of protein localization in organelle (GO:0072595)2.42830757
158detection of other organism (GO:0098543)2.37400993
159positive regulation of cellular amide metabolic process (GO:0034250)2.37270337
160regulation of myeloid leukocyte mediated immunity (GO:0002886)2.35500931
161UV protection (GO:0009650)2.32254565
162protein kinase C signaling (GO:0070528)2.32042815
163negative regulation of innate immune response (GO:0045824)2.30680619
164T cell selection (GO:0045058)2.30207847
165regulation of type I interferon-mediated signaling pathway (GO:0060338)2.28792022
166regulation of leukocyte degranulation (GO:0043300)2.28391203
1673-UTR-mediated mRNA stabilization (GO:0070935)2.28185188
168establishment of mitochondrion localization (GO:0051654)2.27512654
169regulation of amyloid precursor protein catabolic process (GO:1902991)2.27452136
170positive regulation of protein kinase C signaling (GO:0090037)2.27394255
171immunoglobulin mediated immune response (GO:0016064)2.26819378
172regulation of gamma-delta T cell differentiation (GO:0045586)2.24569198
173peptidyl-tyrosine autophosphorylation (GO:0038083)2.23959954
174positive regulation of triglyceride lipase activity (GO:0061365)2.23093766
175positive regulation of lipoprotein lipase activity (GO:0051006)2.23093766
176regulation of apoptotic cell clearance (GO:2000425)2.23083135
177receptor catabolic process (GO:0032801)2.22453986
178phosphatidylglycerol biosynthetic process (GO:0006655)2.21914914
179positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.20548541
180macrophage activation involved in immune response (GO:0002281)2.20381467
181regulation of T-helper 2 cell differentiation (GO:0045628)2.20375749
182leukocyte aggregation (GO:0070486)2.20268437
183regulation of glucose import in response to insulin stimulus (GO:2001273)2.20255677
184chondroitin sulfate catabolic process (GO:0030207)2.19414150
185regulation of histone deacetylation (GO:0031063)2.19092894
186positive T cell selection (GO:0043368)2.18797507
187regulation of dendritic cell antigen processing and presentation (GO:0002604)2.17955201
188histone H3-K9 demethylation (GO:0033169)2.17749742
189negative T cell selection (GO:0043383)2.17142505
190cell migration in hindbrain (GO:0021535)2.16897947
191cell volume homeostasis (GO:0006884)2.16881542
192positive regulation of Rap GTPase activity (GO:0032854)2.16824655
193signal complex assembly (GO:0007172)2.16592698

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.01705614
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.76346398
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.38225146
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.63823821
5VDR_21846776_ChIP-Seq_THP-1_Human3.09981049
6MYC_22102868_ChIP-Seq_BL_Human3.03958971
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.99151222
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.83587081
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.81747589
10TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.59252831
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.53768450
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.38942872
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.35037085
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.27613086
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.26898650
16DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.24372693
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.23905573
18LXR_22292898_ChIP-Seq_THP-1_Human2.08969964
19VDR_24763502_ChIP-Seq_THP-1_Human2.03092267
20KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.01031252
21KDM2B_26808549_Chip-Seq_DND41_Human2.00027364
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.98702742
23KDM2B_26808549_Chip-Seq_SUP-B15_Human1.94481286
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.94066480
25P68_20966046_ChIP-Seq_HELA_Human1.93381084
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.91328624
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.90746439
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.89552959
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.87763963
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87224998
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.86435442
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.84633881
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.84334739
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.79273895
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.78375654
36SA1_27219007_Chip-Seq_ERYTHROID_Human1.78187299
37SPI1_23127762_ChIP-Seq_K562_Human1.74278563
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.70526907
39CLOCK_20551151_ChIP-Seq_293T_Human1.70387367
40TET1_21451524_ChIP-Seq_MESCs_Mouse1.69774020
41TCF7_22412390_ChIP-Seq_EML_Mouse1.67940694
42SMC4_20622854_ChIP-Seq_HELA_Human1.67774721
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67342464
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.66519748
45NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65622323
46MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.63394745
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62827744
48MAF_26560356_Chip-Seq_TH1_Human1.59573990
49TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.58973382
50NFIB_24661679_ChIP-Seq_LUNG_Mouse1.58904480
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57334287
52SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.55509850
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.54278911
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.50642515
55UTX_26944678_Chip-Seq_JUKART_Human1.48904070
56BCL6_27268052_Chip-Seq_Bcells_Human1.48680150
57E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48583550
58UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.47223586
59CREB1_26743006_Chip-Seq_LNCaP_Human1.47156754
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45615869
61BCOR_27268052_Chip-Seq_Bcells_Human1.41595433
62SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39042344
63CIITA_25753668_ChIP-Seq_RAJI_Human1.38743737
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.37757701
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35534657
66KDM2B_26808549_Chip-Seq_JURKAT_Human1.35120018
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35018858
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34093161
69CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.33567025
70CTCF_27219007_Chip-Seq_Bcells_Human1.33190691
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33094875
72SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32504395
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32421196
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.32141404
75SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.30119107
76RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29038411
77TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28821224
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.26553947
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.24494256
80SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.23846387
81MAF_26560356_Chip-Seq_TH2_Human1.22847240
82WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22645889
83EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.21273876
84P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20584245
85ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20462389
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.19799935
87PHF8_20622854_ChIP-Seq_HELA_Human1.19212769
88NCOR1_26117541_ChIP-Seq_K562_Human1.18926761
89IRF8_27001747_Chip-Seq_BMDM_Mouse1.18795851
90MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17943203
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17713544
92CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17713515
93CTCF_26484167_Chip-Seq_Bcells_Mouse1.17558651
94RUNX1_22412390_ChIP-Seq_EML_Mouse1.17400662
95FOXA2_19822575_ChIP-Seq_HepG2_Human1.17376290
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17019937
97MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.12911783
98E2F1_20622854_ChIP-Seq_HELA_Human1.11655375
99DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11010633
100PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11003720
101CTCF_21964334_ChIP-Seq_BJAB-B_Human1.09324830
102RARB_24833708_ChIP-Seq_LIVER_Mouse1.09206341
103FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.09056105
104MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.08565998
105MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08525132
106ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08160973
107SA1_27219007_Chip-Seq_Bcells_Human1.07384996
108MYB_26560356_Chip-Seq_TH1_Human1.07089209
109DROSHA_22980978_ChIP-Seq_HELA_Human1.05318683
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05201250
111RARA_24833708_ChIP-Seq_LIVER_Mouse1.04991822
112TP63_22573176_ChIP-Seq_HFKS_Human1.04810589
113GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04651077
114EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04449378
115GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03419637
116XRN2_22483619_ChIP-Seq_HELA_Human1.02787372
117ETS1_21867929_ChIP-Seq_TH2_Mouse1.01606611
118RUNX1_27514584_Chip-Seq_MCF-7_Human1.01021558
119CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00183050
120CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99698052
121TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99576127
122KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99447282
123CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99138254
124SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98861288
125NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97404600
126RACK7_27058665_Chip-Seq_MCF-7_Human0.93782789
127TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92909808
128MYB_26560356_Chip-Seq_TH2_Human0.92273913
129TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.91908516
130IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.91735813
131EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91174502
132RUNX_20019798_ChIP-Seq_JUKART_Human0.90661904
133TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90045583
134EGR1_19374776_ChIP-ChIP_THP-1_Human0.89874595
135CTCF_21964334_Chip-Seq_Bcells_Human0.89070458
136TP53_22127205_ChIP-Seq_IMR90_Human0.88927676
137MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88242843
138SCL_19346495_ChIP-Seq_HPC-7_Human0.87980759
139DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86471729
140ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.86233522
141PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85953564
142TFEB_21752829_ChIP-Seq_HELA_Human0.85153128
143KDM2B_26808549_Chip-Seq_K562_Human0.84636662
144CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83935588

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.07361050
2MP0005360_urolithiasis4.76663193
3MP0005365_abnormal_bile_salt4.23055029
4MP0005085_abnormal_gallbladder_physiolo3.17957011
5MP0009840_abnormal_foam_cell2.94850210
6MP0005083_abnormal_biliary_tract2.93895562
7MP0005058_abnormal_lysosome_morphology2.85390304
8MP0008438_abnormal_cutaneous_collagen2.78765850
9MP0003172_abnormal_lysosome_physiology2.62771274
10MP0000569_abnormal_digit_pigmentation2.60761880
11MP0003252_abnormal_bile_duct2.50561653
12MP0004185_abnormal_adipocyte_glucose2.32788987
13MP0001849_ear_inflammation2.30713304
14MP0008961_abnormal_basal_metabolism2.25980763
15MP0005220_abnormal_exocrine_pancreas2.22328676
16MP0008260_abnormal_autophagy2.14864362
17MP0010329_abnormal_lipoprotein_level2.05464316
18MP0003303_peritoneal_inflammation1.97411880
19MP0003705_abnormal_hypodermis_morpholog1.97234357
20MP0003300_gastrointestinal_ulcer1.92550493
21MP0003183_abnormal_peptide_metabolism1.88557254
22MP0004859_abnormal_synaptic_plasticity1.85688965
23MP0003195_calcinosis1.84428094
24MP0004858_abnormal_nervous_system1.80917538
25MP0002132_abnormal_respiratory_system1.76932953
26MP0005076_abnormal_cell_differentiation1.74666787
27MP0000604_amyloidosis1.74329036
28MP0002249_abnormal_larynx_morphology1.72360303
29MP0003283_abnormal_digestive_organ1.72003995
30MP0005451_abnormal_body_composition1.71890470
31MP0001944_abnormal_pancreas_morphology1.70082779
32MP0005332_abnormal_amino_acid1.62938395
33MP0001666_abnormal_nutrient_absorption1.62579324
34MP0000609_abnormal_liver_physiology1.62525762
35MP0003329_amyloid_beta_deposits1.58671627
36MP0008875_abnormal_xenobiotic_pharmacok1.56761223
37MP0001545_abnormal_hematopoietic_system1.54874128
38MP0005397_hematopoietic_system_phenotyp1.54874128
39MP0001835_abnormal_antigen_presentation1.53872863
40MP0003806_abnormal_nucleotide_metabolis1.45203919
41MP0003724_increased_susceptibility_to1.43859911
42MP0006082_CNS_inflammation1.42020413
43MP0003122_maternal_imprinting1.40506069
44MP0002089_abnormal_postnatal_growth/wei1.37834312
45MP0002118_abnormal_lipid_homeostasis1.36191671
46MP0002693_abnormal_pancreas_physiology1.35788949
47MP0009384_cardiac_valve_regurgitation1.34954256
48MP0002396_abnormal_hematopoietic_system1.32510784
49MP0005670_abnormal_white_adipose1.31777155
50MP0003191_abnormal_cellular_cholesterol1.30966903
51MP0003763_abnormal_thymus_physiology1.29685388
52MP0000681_abnormal_thyroid_gland1.28282212
53MP0000678_abnormal_parathyroid_gland1.27554987
54MP0009333_abnormal_splenocyte_physiolog1.26694484
55MP0001348_abnormal_lacrimal_gland1.26203250
56MP0003690_abnormal_glial_cell1.25673852
57MP0003868_abnormal_feces_composition1.22856963
58MP0003091_abnormal_cell_migration1.16862197
59MP0005623_abnormal_meninges_morphology1.16811529
60MP0002138_abnormal_hepatobiliary_system1.15693259
61MP0001800_abnormal_humoral_immune1.15318290
62MP0000685_abnormal_immune_system1.14365748
63MP0000858_altered_metastatic_potential1.12909928
64MP0001958_emphysema1.12115144
65MP0010155_abnormal_intestine_physiology1.11475656
66MP0009763_increased_sensitivity_to1.09527815
67MP0002405_respiratory_system_inflammati1.09203987
68MP0005464_abnormal_platelet_physiology1.08579219
69MP0009053_abnormal_anal_canal1.08278070
70MP0001790_abnormal_immune_system1.07359648
71MP0005387_immune_system_phenotype1.07359648
72MP0002998_abnormal_bone_remodeling1.07000759
73MP0000716_abnormal_immune_system1.06109196
74MP0002837_dystrophic_cardiac_calcinosis1.05761405
75MP0003879_abnormal_hair_cell1.04767532
76MP0002078_abnormal_glucose_homeostasis1.04456607
77MP0002928_abnormal_bile_duct1.03736128
78MP0005409_darkened_coat_color1.03513027
79MP0001299_abnormal_eye_distance/1.03493340
80MP0005584_abnormal_enzyme/coenzyme_acti1.03231189
81MP0002398_abnormal_bone_marrow1.01192678
82MP0000598_abnormal_liver_morphology1.01009086
83MP0003436_decreased_susceptibility_to1.00749544
84MP0005390_skeleton_phenotype0.97391226
85MP0002933_joint_inflammation0.95694511
86MP0000566_synostosis0.95173025
87MP0001873_stomach_inflammation0.93672337
88MP0009672_abnormal_birth_weight0.92164844
89MP0001243_abnormal_dermal_layer0.91968916
90MP0003075_altered_response_to0.91208753
91MP0005666_abnormal_adipose_tissue0.89354950
92MP0009278_abnormal_bone_marrow0.88856953
93MP0001502_abnormal_circadian_rhythm0.88513248
94MP0003634_abnormal_glial_cell0.87774602
95MP0002429_abnormal_blood_cell0.87752189
96MP0004808_abnormal_hematopoietic_stem0.87520959
97MP0009643_abnormal_urine_homeostasis0.85875131
98MP0002419_abnormal_innate_immunity0.85814282
99MP0003123_paternal_imprinting0.85387753
100MP0005499_abnormal_olfactory_system0.85247542
101MP0005394_taste/olfaction_phenotype0.85247542
102MP0000013_abnormal_adipose_tissue0.84519450
103MP0001346_abnormal_lacrimal_gland0.83784266
104MP0001915_intracranial_hemorrhage0.83688223
105MP0009780_abnormal_chondrocyte_physiolo0.83068151
106MP0003279_aneurysm0.83058285
107MP0005257_abnormal_intraocular_pressure0.82439079
108MP0004510_myositis0.81594426
109MP0005000_abnormal_immune_tolerance0.81382710
110MP0002723_abnormal_immune_serum0.80427999
111MP0005379_endocrine/exocrine_gland_phen0.79594988
112MP0001270_distended_abdomen0.79252287
113MP0005375_adipose_tissue_phenotype0.79224525
114MP0002932_abnormal_joint_morphology0.78851284
115MP0001533_abnormal_skeleton_physiology0.78552520
116MP0002822_catalepsy0.78317180
117MP0000003_abnormal_adipose_tissue0.78272319
118MP0000767_abnormal_smooth_muscle0.78075030
119MP0003866_abnormal_defecation0.78059954
120MP0001663_abnormal_digestive_system0.77962375
121MP0002896_abnormal_bone_mineralization0.77478725
122MP0005319_abnormal_enzyme/_coenzyme0.77326587
123MP0008469_abnormal_protein_level0.77277230
124MP0001853_heart_inflammation0.76187869
125MP0001851_eye_inflammation0.76050541
126MP0002722_abnormal_immune_system0.75795507
127MP0003453_abnormal_keratinocyte_physiol0.75510937
128MP0004272_abnormal_basement_membrane0.75257382
129MP0008569_lethality_at_weaning0.73342045
130MP0003115_abnormal_respiratory_system0.72053886
131MP0003787_abnormal_imprinting0.71183723
132MP0002166_altered_tumor_susceptibility0.69747901
133MP0002282_abnormal_trachea_morphology0.68184650
134MP0000703_abnormal_thymus_morphology0.67963880
135MP0003890_abnormal_embryonic-extraembry0.67956211
136MP0000920_abnormal_myelination0.67897219
137MP0005503_abnormal_tendon_morphology0.66684486
138MP0009642_abnormal_blood_homeostasis0.65479112
139MP0002420_abnormal_adaptive_immunity0.64680700
140MP0002452_abnormal_antigen_presenting0.64669950
141MP0004947_skin_inflammation0.64669649
142MP0005671_abnormal_response_to0.63917403
143MP0000733_abnormal_muscle_development0.63564971
144MP0001845_abnormal_inflammatory_respons0.62923050
145MP0000371_diluted_coat_color0.62754957
146MP0002971_abnormal_brown_adipose0.61383590
147MP0001819_abnormal_immune_cell0.61037815
148MP0002877_abnormal_melanocyte_morpholog0.60673584
149MP0000249_abnormal_blood_vessel0.59708183
150MP0002653_abnormal_ependyma_morphology0.59200901
151MP0005025_abnormal_response_to0.58309194

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.37722521
2Deep venous thrombosis (HP:0002625)4.59520407
3Xanthomatosis (HP:0000991)4.09790247
4Protrusio acetabuli (HP:0003179)3.94804025
5Abnormality of the common coagulation pathway (HP:0010990)3.88998207
6Hyperlipoproteinemia (HP:0010980)3.79829033
7Prolonged partial thromboplastin time (HP:0003645)3.76819168
8Intrahepatic cholestasis (HP:0001406)3.75518853
9Abnormality of monocarboxylic acid metabolism (HP:0010996)3.57487326
10Obstructive sleep apnea (HP:0002870)3.52689122
11Ketosis (HP:0001946)3.09056085
12Hypobetalipoproteinemia (HP:0003563)3.04721442
13Papilledema (HP:0001085)2.95882014
14Hypoglycemic coma (HP:0001325)2.91049403
15Broad face (HP:0000283)2.90837310
16Neurofibrillary tangles (HP:0002185)2.87111420
17Abnormality of the pancreatic islet cells (HP:0006476)2.86719763
18Abnormality of endocrine pancreas physiology (HP:0012093)2.86719763
19Complement deficiency (HP:0004431)2.85927104
20Systemic lupus erythematosus (HP:0002725)2.83087256
21J-shaped sella turcica (HP:0002680)2.80246376
22Stridor (HP:0010307)2.78057427
23Abnormality of the Achilles tendon (HP:0005109)2.77724731
24Hyperacusis (HP:0010780)2.77364740
25Eczematoid dermatitis (HP:0000976)2.76769964
26Hypoglycemic seizures (HP:0002173)2.75970915
27Abnormality of the intrinsic pathway (HP:0010989)2.74737822
28Thin bony cortex (HP:0002753)2.73149913
29Cerebral aneurysm (HP:0004944)2.72766610
30Premature rupture of membranes (HP:0001788)2.70026933
31Turricephaly (HP:0000262)2.65910482
32Cerebral inclusion bodies (HP:0100314)2.65229743
33Nuclear cataract (HP:0100018)2.63214095
34Cellulitis (HP:0100658)2.57652221
35Skin nodule (HP:0200036)2.56479825
36Late onset (HP:0003584)2.55380293
37Long toe (HP:0010511)2.50790577
38Broad palm (HP:0001169)2.47247498
39Polygenic inheritance (HP:0010982)2.46212075
40Achilles tendon contracture (HP:0001771)2.45594109
41Hyperinsulinemic hypoglycemia (HP:0000825)2.45087973
42Ketoacidosis (HP:0001993)2.44901033
43Abnormality of sulfur amino acid metabolism (HP:0004339)2.42472132
44Mitral stenosis (HP:0001718)2.40181759
45Interstitial pulmonary disease (HP:0006530)2.36517757
46Dysostosis multiplex (HP:0000943)2.34234009
47Urinary glycosaminoglycan excretion (HP:0003541)2.31417948
48Mucopolysacchariduria (HP:0008155)2.31417948
49Peritonitis (HP:0002586)2.29795193
50Myocardial infarction (HP:0001658)2.29203689
51Purpura (HP:0000979)2.26759055
52Abnormality of polysaccharide metabolism (HP:0011012)2.25947374
53Abnormality of glycosaminoglycan metabolism (HP:0004371)2.25947374
54Abnormality of mucopolysaccharide metabolism (HP:0011020)2.25947374
55Increased IgE level (HP:0003212)2.25337580
56Pseudobulbar signs (HP:0002200)2.23372458
57Flat acetabular roof (HP:0003180)2.22875561
58Abnormality of the thoracic spine (HP:0100711)2.22365276
59Joint hemorrhage (HP:0005261)2.21763310
60Epidermoid cyst (HP:0200040)2.21046426
61Disproportionate tall stature (HP:0001519)2.20661074
62Gastrointestinal inflammation (HP:0004386)2.20514699
63Conjugated hyperbilirubinemia (HP:0002908)2.20299147
64Prolonged bleeding time (HP:0003010)2.16980263
65Global brain atrophy (HP:0002283)2.16559765
66Shallow orbits (HP:0000586)2.13980495
67Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.12187996
68Abnormality of the aortic arch (HP:0012303)2.11939151
69Broad distal phalanx of finger (HP:0009836)2.11544195
70Metaphyseal cupping (HP:0003021)2.11465192
71Dislocated radial head (HP:0003083)2.11427704
72Myositis (HP:0100614)2.10949957
73Abnormality of complement system (HP:0005339)2.09826470
74Joint stiffness (HP:0001387)2.08461784
75Abnormality of glycolipid metabolism (HP:0010969)2.07238677
76Abnormality of liposaccharide metabolism (HP:0010968)2.07238677
77Abnormality of glycosphingolipid metabolism (HP:0004343)2.07238677
78Reticulocytosis (HP:0001923)2.06417712
79Hyperammonemia (HP:0001987)2.05717210
80Mitral regurgitation (HP:0001653)2.04734643
81Hypolipoproteinemia (HP:0010981)2.01174687
82Neuronal loss in central nervous system (HP:0002529)2.00799099
83Supernumerary nipples (HP:0002558)2.00786682
84Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.99691543
85Pointed chin (HP:0000307)1.98071194
86Emphysema (HP:0002097)1.96369895
87Mediastinal lymphadenopathy (HP:0100721)1.96250208
88Periodontitis (HP:0000704)1.96235709
89Long palpebral fissure (HP:0000637)1.95958688
90Hypercholesterolemia (HP:0003124)1.95746921
91Abnormality of the radial head (HP:0003995)1.95249591
92Large earlobe (HP:0009748)1.94691790
93Axonal loss (HP:0003447)1.94363436
94Chronic obstructive pulmonary disease (HP:0006510)1.93007329
95Obstructive lung disease (HP:0006536)1.93007329
96Hemorrhage of the eye (HP:0011885)1.92825869
97Slender build (HP:0001533)1.91659096
98Abnormality of macrophages (HP:0004311)1.90680859
99Inflammation of the large intestine (HP:0002037)1.90075382
100Vacuolated lymphocytes (HP:0001922)1.89787561
10111 pairs of ribs (HP:0000878)1.89669467
102Increased cerebral lipofuscin (HP:0011813)1.88902026
103Upper limb amyotrophy (HP:0009129)1.87679651
104Distal upper limb amyotrophy (HP:0007149)1.87679651
105Hypoplastic pelvis (HP:0008839)1.86830862
106Ectopia lentis (HP:0001083)1.86753277
107Pancreatic islet-cell hyperplasia (HP:0004510)1.86592314
108Striae distensae (HP:0001065)1.86358371
109Lymphangioma (HP:0100764)1.85890248
110Ankle clonus (HP:0011448)1.84542488
111Biconcave vertebral bodies (HP:0004586)1.84131220
112Bronchomalacia (HP:0002780)1.83517573
113Mitral valve prolapse (HP:0001634)1.83292760
114Supranuclear gaze palsy (HP:0000605)1.83008375
115Blue sclerae (HP:0000592)1.82699278
116Genu recurvatum (HP:0002816)1.82349327
117Narrow palate (HP:0000189)1.81057280
118Gastrointestinal infarctions (HP:0005244)1.80092625
119Broad metatarsal (HP:0001783)1.79928161
120Flared iliac wings (HP:0002869)1.79923586
121Macroorchidism (HP:0000053)1.79339274
122Agammaglobulinemia (HP:0004432)1.78478068
123Hyperbilirubinemia (HP:0002904)1.78270802
124Recurrent gram-negative bacterial infections (HP:0005420)1.77728298
125Spinal canal stenosis (HP:0003416)1.77061355
126Ulnar bowing (HP:0003031)1.76903734
127Spinal cord lesions (HP:0100561)1.76770881
128Syringomyelia (HP:0003396)1.76770881
129Glomerulonephritis (HP:0000099)1.76752477
130Generalized hyperpigmentation (HP:0007440)1.76124417
131Growth hormone excess (HP:0000845)1.75971749
132Abnormality of the peritoneum (HP:0002585)1.75462586
133Chronic otitis media (HP:0000389)1.75405805
134Cupped ribs (HP:0000887)1.74732433
135Hypoalphalipoproteinemia (HP:0003233)1.73872697
136Meningitis (HP:0001287)1.73828750
137Aneurysm (HP:0002617)1.73311730
138Orchitis (HP:0100796)1.73164238
139Spondylolisthesis (HP:0003302)1.70272572
140Atelectasis (HP:0100750)1.70186379
141Vertebral compression fractures (HP:0002953)1.70137647
142Opisthotonus (HP:0002179)1.68747717
143Cervical subluxation (HP:0003308)1.68478912
144Symptomatic seizures (HP:0011145)1.67742604
145Megalencephaly (HP:0001355)1.67075696
146Hypoplasia of the thymus (HP:0000778)1.66514319
147Abnormality of pyrimidine metabolism (HP:0004353)1.65924822
148Abnormality of the fingertips (HP:0001211)1.65894887
149Thoracic kyphosis (HP:0002942)1.65893179
150Epistaxis (HP:0000421)1.65589331
151Hypertriglyceridemia (HP:0002155)1.64970373
152Abnormality of the lumbar spine (HP:0100712)1.64836054
153Gingivitis (HP:0000230)1.64285263
154Recurrent abscess formation (HP:0002722)1.64058275
155Congenital glaucoma (HP:0001087)1.63353434
156Bladder diverticulum (HP:0000015)1.62477523
157Abnormality of methionine metabolism (HP:0010901)1.61198729
158Abnormality of glutamine family amino acid metabolism (HP:0010902)1.60674523
159Deep palmar crease (HP:0006191)1.60667979
160Amyloidosis (HP:0011034)1.58367225
161Abnormal gallbladder physiology (HP:0012438)1.58068526
162Cholecystitis (HP:0001082)1.58068526
163Ankle contracture (HP:0006466)1.57978893
164Abnormality of iron homeostasis (HP:0011031)1.57838068
165Prominent metopic ridge (HP:0005487)1.57400804
166Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.57103952
167Colitis (HP:0002583)1.56947808
168Adactyly (HP:0009776)1.56795260
169Recurrent bacterial skin infections (HP:0005406)1.56022017
170Increased serum ferritin (HP:0003281)1.55279301
171Hallux valgus (HP:0001822)1.54735613

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR23.71329527
2TRIB33.30818512
3FGFR43.28603558
4SIK13.25869843
5ERN13.10966126
6PASK3.05896602
7MAP3K103.02130267
8BRD42.78072537
9PRPF4B2.63467362
10SMG12.29720058
11TYRO32.03626127
12PDGFRA1.98501427
13SIK31.94499725
14TAOK31.88066634
15ITK1.84783753
16SIK21.82914915
17TNK21.82485799
18PKN21.79563421
19CDK121.74034361
20EPHB11.65297869
21MAP3K131.58469211
22MAP3K111.53870114
23EEF2K1.51131868
24TLK11.50990595
25INSRR1.42691190
26ICK1.42194252
27RIPK41.35571068
28BLK1.32832255
29HIPK21.32823999
30PTK61.32255846
31BCKDK1.29858044
32CDC42BPA1.28996442
33NTRK21.28796210
34MAP4K11.28330109
35IRAK41.26507689
36RPS6KA41.23040510
37TYK21.19816915
38CAMK1G1.14640502
39FGFR31.14520980
40TESK21.13381193
41MAP3K61.12968782
42GRK61.09348055
43FES1.08826310
44FGFR11.08716289
45CAMKK11.05154333
46MAP2K61.01513480
47JAK31.01004430
48DYRK1B1.00112446
49NEK90.99693313
50PDPK10.97361982
51CSF1R0.93601297
52TTN0.93390499
53MAPK120.91969163
54TAOK10.91337049
55UHMK10.89364096
56IRAK30.88936296
57PRKD10.88150329
58KSR10.86937488
59NTRK10.85574665
60MAP3K10.85504795
61PTK20.84572929
62MTOR0.83210469
63RPS6KC10.82853952
64RPS6KL10.82853952
65BTK0.82603426
66EPHB20.81712988
67MAP3K140.81461471
68NME20.80766704
69EIF2AK30.76347492
70PDK10.73568416
71JAK10.73285763
72PRKD30.72128829
73DDR20.68173134
74RPS6KA60.67753653
75RET0.65434000
76HCK0.65179966
77MAPK70.64488659
78MARK20.63871692
79PTK2B0.63807284
80FLT30.62779914
81PKN10.62680033
82CAMK1D0.61259054
83SCYL20.61047492
84PAK60.60831290
85JAK20.59641726
86DAPK30.59283519
87PAK20.58763759
88MAP2K20.58307682
89CHUK0.58035061
90BMX0.57120092
91MAP3K30.55678712
92PDGFRB0.55132514
93CDK60.54363177
94MAP2K40.54268141
95KSR20.54142487
96MAPK110.53503068
97ZAP700.53073638
98CCNB10.53041042
99ILK0.52254048
100BCR0.51318247
101PAK30.50279989
102RPS6KA20.49348204
103PRKCZ0.49241622
104IKBKE0.49224100
105IRAK20.48889675
106TBK10.48722412
107MARK30.48329269
108TAOK20.48204381
109CSNK1A1L0.47308101
110CDK90.46873709
111LRRK20.45876101
112LCK0.45781029
113DYRK30.43303210
114KIT0.42456139
115FGR0.42339563
116TESK10.42055874
117MAPKAPK30.41756735
118SYK0.40625115
119PRKCQ0.40622616
120IKBKB0.39759495
121MAP2K30.37936578
122PRKCH0.37478285
123LYN0.37343980
124EPHA20.36766491
125MAPK30.36576290
126WNK10.36381279
127RIPK10.36072086
128CDK40.35925426
129MAP3K70.35468678
130MAPK150.35290665
131PRKD20.34680959
132RPS6KA10.34509681
133FYN0.34209591
134CSK0.34200727

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.08479669
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.80134981
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.32435490
4Maturity onset diabetes of the young_Homo sapiens_hsa049503.23008514
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.11912814
6Sulfur relay system_Homo sapiens_hsa041222.59099479
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.52041845
8Tryptophan metabolism_Homo sapiens_hsa003802.20383730
9Arginine biosynthesis_Homo sapiens_hsa002202.16383449
10Lysine degradation_Homo sapiens_hsa003102.14848368
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.12127784
12Staphylococcus aureus infection_Homo sapiens_hsa051502.09746956
13Complement and coagulation cascades_Homo sapiens_hsa046102.06991256
14Selenocompound metabolism_Homo sapiens_hsa004502.03075695
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.99005242
16Fatty acid degradation_Homo sapiens_hsa000711.98749573
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.92883421
18Fatty acid metabolism_Homo sapiens_hsa012121.84490232
19Acute myeloid leukemia_Homo sapiens_hsa052211.77404900
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.72199827
21Butanoate metabolism_Homo sapiens_hsa006501.67471574
22Steroid biosynthesis_Homo sapiens_hsa001001.57711528
23Protein export_Homo sapiens_hsa030601.57350434
24One carbon pool by folate_Homo sapiens_hsa006701.57034929
25Folate biosynthesis_Homo sapiens_hsa007901.56265631
26Sulfur metabolism_Homo sapiens_hsa009201.54867082
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35912589
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.30487150
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30081723
30PPAR signaling pathway_Homo sapiens_hsa033201.28715774
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.25522930
32Fatty acid elongation_Homo sapiens_hsa000621.25464930
33Phospholipase D signaling pathway_Homo sapiens_hsa040721.18709705
34Toxoplasmosis_Homo sapiens_hsa051451.18317960
35Histidine metabolism_Homo sapiens_hsa003401.16449019
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.15984231
37Tuberculosis_Homo sapiens_hsa051521.12893524
38Allograft rejection_Homo sapiens_hsa053301.12878237
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08142447
40Bile secretion_Homo sapiens_hsa049761.07576471
41Influenza A_Homo sapiens_hsa051641.06791719
42TNF signaling pathway_Homo sapiens_hsa046681.06566036
43Phenylalanine metabolism_Homo sapiens_hsa003601.06228207
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05897331
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05500175
46Choline metabolism in cancer_Homo sapiens_hsa052311.04654393
47Autoimmune thyroid disease_Homo sapiens_hsa053201.04430104
48Propanoate metabolism_Homo sapiens_hsa006401.04170895
49Peroxisome_Homo sapiens_hsa041461.02283407
50GnRH signaling pathway_Homo sapiens_hsa049121.01226839
51Biosynthesis of amino acids_Homo sapiens_hsa012301.01016995
52Graft-versus-host disease_Homo sapiens_hsa053320.99678612
53Hepatitis C_Homo sapiens_hsa051600.97879765
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95790963
55Prolactin signaling pathway_Homo sapiens_hsa049170.95485382
56Fructose and mannose metabolism_Homo sapiens_hsa000510.94875041
57Arginine and proline metabolism_Homo sapiens_hsa003300.94404944
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93414750
59Prion diseases_Homo sapiens_hsa050200.90494118
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87795005
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.86133604
62ABC transporters_Homo sapiens_hsa020100.86121872
63Pyruvate metabolism_Homo sapiens_hsa006200.85093825
64Endometrial cancer_Homo sapiens_hsa052130.84950782
65Herpes simplex infection_Homo sapiens_hsa051680.84753299
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84528881
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.84243812
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83532116
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82821860
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.81770969
71Type II diabetes mellitus_Homo sapiens_hsa049300.81105116
72Insulin resistance_Homo sapiens_hsa049310.80804721
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.80506370
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80355572
75Primary immunodeficiency_Homo sapiens_hsa053400.79634259
76B cell receptor signaling pathway_Homo sapiens_hsa046620.78917731
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.78702171
78Insulin signaling pathway_Homo sapiens_hsa049100.77857519
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77473471
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77359453
81ErbB signaling pathway_Homo sapiens_hsa040120.77341883
82Tyrosine metabolism_Homo sapiens_hsa003500.75826390
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75103621
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.74623182
85Endocytosis_Homo sapiens_hsa041440.73461353
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73180431
87beta-Alanine metabolism_Homo sapiens_hsa004100.71789524
88Asthma_Homo sapiens_hsa053100.71655821
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70795684
90Bladder cancer_Homo sapiens_hsa052190.70046624
91Non-small cell lung cancer_Homo sapiens_hsa052230.69933393
92Amoebiasis_Homo sapiens_hsa051460.69253232
93Apoptosis_Homo sapiens_hsa042100.68928503
94Chemokine signaling pathway_Homo sapiens_hsa040620.67625871
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.65869497
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.65797801
97Lysosome_Homo sapiens_hsa041420.65566648
98Other glycan degradation_Homo sapiens_hsa005110.65375510
99Galactose metabolism_Homo sapiens_hsa000520.65336196
100Carbon metabolism_Homo sapiens_hsa012000.64884084
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64779333
102MAPK signaling pathway_Homo sapiens_hsa040100.64345083
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64286220
104Chemical carcinogenesis_Homo sapiens_hsa052040.63287503
105Malaria_Homo sapiens_hsa051440.63044111
106Platelet activation_Homo sapiens_hsa046110.62848949
107HTLV-I infection_Homo sapiens_hsa051660.62647428
108Viral myocarditis_Homo sapiens_hsa054160.62556113
109Inositol phosphate metabolism_Homo sapiens_hsa005620.62525521
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.61276164
111Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60644133
112Measles_Homo sapiens_hsa051620.59769855
113Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59173965
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58428549
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57941017
116VEGF signaling pathway_Homo sapiens_hsa043700.57678612
117Chronic myeloid leukemia_Homo sapiens_hsa052200.57401704
118Colorectal cancer_Homo sapiens_hsa052100.57344558
119T cell receptor signaling pathway_Homo sapiens_hsa046600.56667633
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55642075
121Salmonella infection_Homo sapiens_hsa051320.55014153
122HIF-1 signaling pathway_Homo sapiens_hsa040660.53605656
123Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53464051
124Phagosome_Homo sapiens_hsa041450.53221950
125Type I diabetes mellitus_Homo sapiens_hsa049400.52828816
126Renal cell carcinoma_Homo sapiens_hsa052110.52244414
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.51698745
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.51536709
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.50962215
130Long-term potentiation_Homo sapiens_hsa047200.50906208
131Pentose phosphate pathway_Homo sapiens_hsa000300.50579982
132Glucagon signaling pathway_Homo sapiens_hsa049220.50352242
133Glioma_Homo sapiens_hsa052140.49671131
134Osteoclast differentiation_Homo sapiens_hsa043800.49451110
135African trypanosomiasis_Homo sapiens_hsa051430.49259060
136Pancreatic cancer_Homo sapiens_hsa052120.49255616
137Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45447278
138Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43173963
139Fat digestion and absorption_Homo sapiens_hsa049750.43136122
140Notch signaling pathway_Homo sapiens_hsa043300.42685195
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.42499206
142Retinol metabolism_Homo sapiens_hsa008300.41939096
143Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40121479
144Leishmaniasis_Homo sapiens_hsa051400.34925938
145Small cell lung cancer_Homo sapiens_hsa052220.33375239
146Caffeine metabolism_Homo sapiens_hsa002320.32862796
147Starch and sucrose metabolism_Homo sapiens_hsa005000.31006933
148Estrogen signaling pathway_Homo sapiens_hsa049150.30525649
149NF-kappa B signaling pathway_Homo sapiens_hsa040640.30502411
150Prostate cancer_Homo sapiens_hsa052150.30084763
151AMPK signaling pathway_Homo sapiens_hsa041520.28165735
152Hepatitis B_Homo sapiens_hsa051610.27265953
153Toll-like receptor signaling pathway_Homo sapiens_hsa046200.25387623
154Pertussis_Homo sapiens_hsa051330.24643657
155Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24095059
156Cocaine addiction_Homo sapiens_hsa050300.24035727
157Proteoglycans in cancer_Homo sapiens_hsa052050.23349112
158Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21566842
159mTOR signaling pathway_Homo sapiens_hsa041500.20363529
160Glycerolipid metabolism_Homo sapiens_hsa005610.19164472

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