PCED1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the GDSL/SGNH-like acyl-esterase family. Members of this family are hydrolases thought to function in modification of biopolymers on the cell surface. Alternate splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)8.71740497
2doxorubicin metabolic process (GO:0044598)8.71740497
3daunorubicin metabolic process (GO:0044597)8.71740497
4negative regulation of cell killing (GO:0031342)6.71189247
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.71189247
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.65314702
7positive regulation of gamma-delta T cell activation (GO:0046645)6.34133809
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.27020127
9regulation of B cell receptor signaling pathway (GO:0050855)5.93065066
10maintenance of protein location in nucleus (GO:0051457)5.90934711
11negative T cell selection (GO:0043383)5.87072755
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.86920843
13regulation of nuclear cell cycle DNA replication (GO:0033262)5.65865760
14protein localization to kinetochore (GO:0034501)5.58785254
15negative thymic T cell selection (GO:0045060)5.53993558
16antigen processing and presentation of endogenous antigen (GO:0019883)5.53374751
17histone H4-K12 acetylation (GO:0043983)5.52731607
18aminoglycoside antibiotic metabolic process (GO:0030647)5.49427637
19regulation of telomere maintenance via telomerase (GO:0032210)5.48241565
20interferon-gamma production (GO:0032609)5.36190819
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.32057114
22cellular response to interleukin-15 (GO:0071350)5.32025145
23response to interleukin-15 (GO:0070672)5.18747468
24regulation of mammary gland epithelial cell proliferation (GO:0033599)5.14096850
25histone H4-K5 acetylation (GO:0043981)5.14055979
26histone H4-K8 acetylation (GO:0043982)5.14055979
27negative regulation of telomerase activity (GO:0051974)5.07421081
28somite rostral/caudal axis specification (GO:0032525)5.06575117
29negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.99558447
30regulation of gamma-delta T cell differentiation (GO:0045586)4.96238714
31positive thymic T cell selection (GO:0045059)4.92309999
32positive T cell selection (GO:0043368)4.87621904
33rRNA transcription (GO:0009303)4.82992627
34regulation of gamma-delta T cell activation (GO:0046643)4.79794724
35T cell migration (GO:0072678)4.75696060
36negative regulation of epidermis development (GO:0045683)4.74075060
37muscle organ morphogenesis (GO:0048644)4.72869182
38mitotic sister chromatid segregation (GO:0000070)4.72480306
39regulation of MHC class I biosynthetic process (GO:0045343)4.72097390
40thymic T cell selection (GO:0045061)4.69958117
41regulation of response to osmotic stress (GO:0047484)4.63346325
42regulation of regulatory T cell differentiation (GO:0045589)4.61351941
43negative regulation of cell cycle G2/M phase transition (GO:1902750)4.60926647
44leukocyte aggregation (GO:0070486)4.55462118
45T cell selection (GO:0045058)4.53026187
46negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.48598337
47regulation of T cell tolerance induction (GO:0002664)4.46853668
48positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.42380075
49protein localization to chromosome, centromeric region (GO:0071459)4.32214606
50negative regulation of telomere maintenance (GO:0032205)4.26661722
51regulation of natural killer cell mediated immunity (GO:0002715)4.26224456
52regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.26224456
53heterochromatin organization (GO:0070828)4.23621260
54rRNA methylation (GO:0031167)4.21176043
55nuclear pore complex assembly (GO:0051292)4.18413098
56regulation of alpha-beta T cell proliferation (GO:0046640)4.15144697
57regulation of T cell mediated cytotoxicity (GO:0001914)4.12406154
58regulation of translation in response to stress (GO:0043555)4.10422670
59negative regulation of T cell mediated immunity (GO:0002710)4.09731089
60positive regulation of T cell mediated cytotoxicity (GO:0001916)4.07183255
61tolerance induction (GO:0002507)4.05292700
62negative regulation of lymphocyte mediated immunity (GO:0002707)4.04164560
63rRNA modification (GO:0000154)4.04064657
64histone H4-K16 acetylation (GO:0043984)4.01251854
65DNA replication checkpoint (GO:0000076)3.99598862
66DNA replication-dependent nucleosome organization (GO:0034723)3.94427269
67DNA replication-dependent nucleosome assembly (GO:0006335)3.94427269
68regulation of B cell differentiation (GO:0045577)3.93523971
69sister chromatid segregation (GO:0000819)3.92704386
70regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.86867812
71regulation of leukocyte mediated cytotoxicity (GO:0001910)3.86685536
72positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.86341349
73positive regulation of DNA-dependent DNA replication (GO:2000105)3.84535963
74regulation of tolerance induction (GO:0002643)3.83540299
75positive regulation of tolerance induction (GO:0002645)3.83120875
76positive regulation of alpha-beta T cell proliferation (GO:0046641)3.81344662
77negative regulation of epidermal cell differentiation (GO:0045605)3.80629115
78T cell receptor signaling pathway (GO:0050852)3.80047922
79positive regulation of granulocyte differentiation (GO:0030854)3.79633811
80positive regulation of natural killer cell mediated immunity (GO:0002717)3.76401309
81nuclear pore organization (GO:0006999)3.75108421
82pre-miRNA processing (GO:0031054)3.72903197
83antigen processing and presentation via MHC class Ib (GO:0002475)3.72246720
84chromatin assembly (GO:0031497)3.72179310
85positive regulation of B cell differentiation (GO:0045579)3.71496508
86antigen receptor-mediated signaling pathway (GO:0050851)3.68986109
87B cell receptor signaling pathway (GO:0050853)3.66672217
88cytidine deamination (GO:0009972)3.65774270
89cytidine metabolic process (GO:0046087)3.65774270
90cytidine catabolic process (GO:0006216)3.65774270
91negative regulation of leukocyte mediated immunity (GO:0002704)3.65424835
92neutrophil activation involved in immune response (GO:0002283)3.63891055
93ribosome biogenesis (GO:0042254)3.63058466
94nucleoside transmembrane transport (GO:1901642)3.62638063
95intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.61761397
96mast cell activation (GO:0045576)3.61359834
97positive regulation of protein deacetylation (GO:0090312)3.61013833
98regulation of apoptotic process involved in morphogenesis (GO:1902337)3.55404495
99regulation of cell killing (GO:0031341)3.54816805
100pyrimidine ribonucleoside catabolic process (GO:0046133)3.54169010
101formation of translation preinitiation complex (GO:0001731)3.54027996
102positive regulation of cell killing (GO:0031343)3.53491201
103cellular response to type I interferon (GO:0071357)3.52086325
104type I interferon signaling pathway (GO:0060337)3.52086325
105notochord development (GO:0030903)3.50633191
106regulation of cilium movement (GO:0003352)3.50624201
107response to type I interferon (GO:0034340)3.50420577
108activated T cell proliferation (GO:0050798)3.50320458
109immunoglobulin mediated immune response (GO:0016064)3.48201268
110Arp2/3 complex-mediated actin nucleation (GO:0034314)3.41418827
111regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.40980541
112regulation of gene silencing by RNA (GO:0060966)3.39033623
113regulation of posttranscriptional gene silencing (GO:0060147)3.39033623
114regulation of gene silencing by miRNA (GO:0060964)3.39033623
115trophectodermal cell differentiation (GO:0001829)3.38503830
116branching involved in mammary gland duct morphogenesis (GO:0060444)3.35459844
117positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.34972303
118regulation of telomere maintenance (GO:0032204)3.29349148
119neutrophil activation (GO:0042119)3.29110011
120positive regulation of histone deacetylation (GO:0031065)3.27749270
121retinoic acid receptor signaling pathway (GO:0048384)3.26836025
122T cell costimulation (GO:0031295)3.26565573
123detection of bacterium (GO:0016045)3.25991042
124regulation of T cell receptor signaling pathway (GO:0050856)3.25267836
125DNA duplex unwinding (GO:0032508)3.24367915
126mRNA stabilization (GO:0048255)3.23956000
127RNA stabilization (GO:0043489)3.23956000
128transcription from mitochondrial promoter (GO:0006390)3.23578953
129maintenance of protein localization in organelle (GO:0072595)3.23453143
130lymphocyte costimulation (GO:0031294)3.22410897
131primitive streak formation (GO:0090009)3.21835370
132pore complex assembly (GO:0046931)3.20543650
133DNA geometric change (GO:0032392)3.20050020
134positive regulation of isotype switching (GO:0045830)3.18006924
135hormone catabolic process (GO:0042447)3.17022377
136phenol-containing compound catabolic process (GO:0019336)3.16007316
137detection of other organism (GO:0098543)3.15937113
138negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.15172485
139leukocyte degranulation (GO:0043299)3.14504490
140dendritic cell chemotaxis (GO:0002407)3.13427556
141negative regulation of T cell apoptotic process (GO:0070233)3.13199332
142lymphocyte migration (GO:0072676)3.12868024
143positive regulation of interleukin-2 production (GO:0032743)3.12795901
144regulation of telomerase activity (GO:0051972)3.12450818
145positive regulation of T cell mediated immunity (GO:0002711)3.12109712
146pseudouridine synthesis (GO:0001522)3.11443347
147positive regulation of defense response to virus by host (GO:0002230)3.11107391
148NIK/NF-kappaB signaling (GO:0038061)3.10228774
149ribosomal small subunit biogenesis (GO:0042274)3.09957950
150positive regulation by symbiont of host defense response (GO:0052509)3.09776196
151modulation by symbiont of host defense response (GO:0052031)3.09776196
152modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.09776196
153modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.09776196
154positive regulation by organism of defense response of other organism involved in symbiotic interact3.09776196
155modulation by symbiont of host immune response (GO:0052553)3.09776196
156positive regulation of interleukin-4 production (GO:0032753)3.09278548
157regulation of T cell mediated immunity (GO:0002709)3.09138315
158DNA deamination (GO:0045006)3.08576054
159granulocyte activation (GO:0036230)3.08064086
160negative regulation of interleukin-12 production (GO:0032695)3.07520486
161positive regulation of lymphocyte mediated immunity (GO:0002708)3.07111508
162cell fate commitment involved in formation of primary germ layer (GO:0060795)3.07033712
163histone H3-K4 methylation (GO:0051568)3.06356542
164mitotic chromosome condensation (GO:0007076)3.05635947
165intestinal epithelial cell development (GO:0060576)3.00046612
166respiratory burst (GO:0045730)2.99046530
167DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.98006805
168positive regulation of B cell mediated immunity (GO:0002714)2.97636896
169positive regulation of immunoglobulin mediated immune response (GO:0002891)2.97636896
170B cell mediated immunity (GO:0019724)2.97336172
171myeloid cell activation involved in immune response (GO:0002275)2.97248462
172regulation of alpha-beta T cell activation (GO:0046634)2.97037882
173quinone metabolic process (GO:1901661)2.93631641
174negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.93437888
175regulation of double-strand break repair (GO:2000779)2.92000398
176response to dietary excess (GO:0002021)2.90028689
177regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.89779103
178mitochondrial DNA replication (GO:0006264)2.88182286
179ribonucleoprotein complex biogenesis (GO:0022613)2.85097843
180negative regulation of viral release from host cell (GO:1902187)2.84767132
181negative regulation of gene silencing (GO:0060969)2.84542203
182GDP-mannose metabolic process (GO:0019673)2.82967146
183tachykinin receptor signaling pathway (GO:0007217)2.78957117
184DNA unwinding involved in DNA replication (GO:0006268)2.78633711
185intracellular estrogen receptor signaling pathway (GO:0030520)2.77560706
186maternal placenta development (GO:0001893)2.77324239
187cullin deneddylation (GO:0010388)2.76176618
188regulation of interleukin-2 biosynthetic process (GO:0045076)2.74960095
189histone H3 acetylation (GO:0043966)2.73924679
190DNA damage response, detection of DNA damage (GO:0042769)2.72392717
191spindle assembly (GO:0051225)2.71101904
192intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.70499959
193regulation of DNA-dependent DNA replication (GO:0090329)2.69630552
194regulation of isotype switching to IgG isotypes (GO:0048302)2.68352623

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.77556218
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.60927778
3E2F7_22180533_ChIP-Seq_HELA_Human5.58919771
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.19590038
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.19590038
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.19590038
7BP1_19119308_ChIP-ChIP_Hs578T_Human5.00681435
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.93013661
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.77453706
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.70950477
11RUNX_20019798_ChIP-Seq_JUKART_Human3.48864796
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.28911631
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.96323507
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.95901605
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.75805317
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.73367271
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.68843205
18SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.68106061
19NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.65321148
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.62326959
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.47750002
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.45018765
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.44082806
24IRF8_27001747_Chip-Seq_BMDM_Mouse2.40396488
25MYC_22102868_ChIP-Seq_BL_Human2.33011998
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.29613141
27GATA3_27048872_Chip-Seq_THYMUS_Human2.27277406
28SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.21681850
29MYC_18555785_ChIP-Seq_MESCs_Mouse2.21177815
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07571268
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.06367624
32TCF3_18692474_ChIP-Seq_MESCs_Mouse2.04283612
33TCF3_18692474_ChIP-Seq_MEFs_Mouse2.02409202
34SPI1_23127762_ChIP-Seq_K562_Human1.94198275
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.92996766
36NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.92474131
37SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.91567397
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.91303320
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.89536440
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.88699989
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.87679837
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.86663220
43GATA3_26560356_Chip-Seq_TH2_Human1.85737668
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.85025687
45VDR_24763502_ChIP-Seq_THP-1_Human1.82905772
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.78618888
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.78493243
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.74540474
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.72941336
50NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.72924588
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.72756460
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.63800250
53KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.62915676
54LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.60172757
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57073569
56NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.56923973
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56634145
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.55399624
59MYC_18358816_ChIP-ChIP_MESCs_Mouse1.55079537
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50964283
61IRF1_19129219_ChIP-ChIP_H3396_Human1.50676950
62NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.49403055
63ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.48960823
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.47475077
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.46231356
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.44446887
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43754330
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.43676180
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38085324
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37457080
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37033700
72POU5F1_16518401_ChIP-PET_MESCs_Mouse1.36272042
73EST1_17652178_ChIP-ChIP_JURKAT_Human1.35715363
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.35061616
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33313365
76CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27567322
77GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27293105
78TCF7_22412390_ChIP-Seq_EML_Mouse1.27179657
79HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26648302
80BCL6_27268052_Chip-Seq_Bcells_Human1.25674871
81KDM2B_26808549_Chip-Seq_DND41_Human1.24380946
82POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.23648891
83FOXP3_21729870_ChIP-Seq_TREG_Human1.23333072
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21701725
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21531101
86TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.20403705
87SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20393938
88NANOG_18692474_ChIP-Seq_MEFs_Mouse1.19414736
89NANOG_18692474_ChIP-Seq_MESCs_Mouse1.18906153
90IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.18766283
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18645529
92MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.17798434
93RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.17165230
94OCT4_18692474_ChIP-Seq_MEFs_Mouse1.16988213
95CREB1_15753290_ChIP-ChIP_HEK293T_Human1.16500382
96SCL_19346495_ChIP-Seq_HPC-7_Human1.15750977
97GATA1_19941827_ChIP-Seq_MEL_Mouse1.15730157
98KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.15369167
99SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.15243712
100CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15017442
101ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14988632
102CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14535576
103CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14441005
104TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12918056
105PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11462342
106CIITA_25753668_ChIP-Seq_RAJI_Human1.10740870
107MYB_26560356_Chip-Seq_TH1_Human1.09983983
108TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09185156
109BCOR_27268052_Chip-Seq_Bcells_Human1.08898432
110VDR_21846776_ChIP-Seq_THP-1_Human1.08835012
111PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.07827120
112SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07481340
113SOX2_18692474_ChIP-Seq_MESCs_Mouse1.07324364
114VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06346008
115NCOR1_26117541_ChIP-Seq_K562_Human1.06168668
116XRN2_22483619_ChIP-Seq_HELA_Human1.05121161
117GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04050081
118PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04035401
119PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04020695
120NANOG_21062744_ChIP-ChIP_HESCs_Human1.03876801
121JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.03192187
122VDR_24787735_ChIP-Seq_THP-1_Human1.02964719
123PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01991831
124E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01841937
125KDM5A_27292631_Chip-Seq_BREAST_Human1.01537601
126ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01498262
127KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.01171660
128SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00938906
129SOX2_18692474_ChIP-Seq_MEFs_Mouse1.00867237
130TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00113859
131NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99510593
132SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98462329
133MAF_26560356_Chip-Seq_TH1_Human0.98285419
134VDR_23849224_ChIP-Seq_CD4+_Human0.97787049
135Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97241724
136ETS1_20019798_ChIP-Seq_JURKAT_Human0.96848221
137FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96826846
138KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96518791
139KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95421502
140ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94374217
141GATA1_19941826_ChIP-Seq_K562_Human0.94313160
142ELF1_20517297_ChIP-Seq_JURKAT_Human0.93963337
143PU_27001747_Chip-Seq_BMDM_Mouse0.93886288
144UTX_26944678_Chip-Seq_JUKART_Human0.93767678
145E2F1_17053090_ChIP-ChIP_MCF-7_Human0.93301731
146KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92281108
147MYB_26560356_Chip-Seq_TH2_Human0.91987126
148P300_27268052_Chip-Seq_Bcells_Human0.91905623
149ELK3_25401928_ChIP-Seq_HUVEC_Human0.90906778
150GATA1_22025678_ChIP-Seq_K562_Human0.90700376
151E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.90242982
152ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89500722
153* SPI1_23547873_ChIP-Seq_NB4_Human0.89201900
154RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88924885
155NANOG_16518401_ChIP-PET_MESCs_Mouse0.88736528
156RUNX1_22412390_ChIP-Seq_EML_Mouse0.88287320
157KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.87045372
158STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.86942650
159GABP_17652178_ChIP-ChIP_JURKAT_Human0.85982976
160GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85225129
161SPI1_20517297_ChIP-Seq_HL60_Human0.84848367
162MYCN_18555785_ChIP-Seq_MESCs_Mouse0.84479845
163MAF_26560356_Chip-Seq_TH2_Human0.84031848
164GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83553709
165GABP_19822575_ChIP-Seq_HepG2_Human0.83470707
166KDM2B_26808549_Chip-Seq_JURKAT_Human0.83344922
167CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82551137
168KAP1_27257070_Chip-Seq_ESCs_Mouse0.81233101
169TTF2_22483619_ChIP-Seq_HELA_Human0.80412268
170LXR_22292898_ChIP-Seq_THP-1_Human0.78994224
171NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.78730797
172GATA3_26560356_Chip-Seq_TH1_Human0.78628261
173EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.78594367
174RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78580399
175RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.78040934
176GATA2_21666600_ChIP-Seq_HMVEC_Human0.77730986

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004264_abnormal_extraembryonic_tissu3.80672612
2MP0008057_abnormal_DNA_replication3.76389590
3MP0002254_reproductive_system_inflammat3.70896269
4MP0006292_abnormal_olfactory_placode3.63125352
5MP0003724_increased_susceptibility_to3.59178058
6MP0005075_abnormal_melanosome_morpholog3.38806850
7MP0004957_abnormal_blastocyst_morpholog3.23513350
8MP0003011_delayed_dark_adaptation3.19536138
9MP0009785_altered_susceptibility_to3.08164281
10MP0003890_abnormal_embryonic-extraembry2.94504009
11MP0002148_abnormal_hypersensitivity_rea2.58251906
12MP0002419_abnormal_innate_immunity2.57937817
13MP0005499_abnormal_olfactory_system2.44460019
14MP0005394_taste/olfaction_phenotype2.44460019
15MP0010352_gastrointestinal_tract_polyps2.35829426
16MP0005464_abnormal_platelet_physiology2.28709370
17MP0003866_abnormal_defecation2.26438901
18MP0002396_abnormal_hematopoietic_system2.23610432
19MP0002332_abnormal_exercise_endurance2.23506497
20MP0001873_stomach_inflammation2.21860817
21MP0003300_gastrointestinal_ulcer2.15309746
22MP0003077_abnormal_cell_cycle2.11434619
23MP0002653_abnormal_ependyma_morphology2.04047637
24MP0003303_peritoneal_inflammation2.01027787
25MP0006082_CNS_inflammation1.97984469
26MP0004947_skin_inflammation1.96784332
27MP0003122_maternal_imprinting1.93934623
28MP0010094_abnormal_chromosome_stability1.90634458
29MP0003763_abnormal_thymus_physiology1.90482387
30MP0005380_embryogenesis_phenotype1.90385400
31MP0001672_abnormal_embryogenesis/_devel1.90385400
32MP0003121_genomic_imprinting1.90069317
33MP0002166_altered_tumor_susceptibility1.88261699
34MP0003111_abnormal_nucleus_morphology1.87834338
35MP0001845_abnormal_inflammatory_respons1.83400326
36MP0001533_abnormal_skeleton_physiology1.81473185
37MP0004858_abnormal_nervous_system1.80762984
38MP0002088_abnormal_embryonic_growth/wei1.76997546
39MP0003984_embryonic_growth_retardation1.76919800
40MP0006035_abnormal_mitochondrial_morpho1.75186115
41MP0000350_abnormal_cell_proliferation1.72660731
42MP0000678_abnormal_parathyroid_gland1.69275909
43MP0003693_abnormal_embryo_hatching1.67928410
44MP0000465_gastrointestinal_hemorrhage1.58401818
45MP0000490_abnormal_crypts_of1.54719726
46MP0008961_abnormal_basal_metabolism1.53187592
47MP0005257_abnormal_intraocular_pressure1.51394543
48MP0002086_abnormal_extraembryonic_tissu1.47294240
49MP0003705_abnormal_hypodermis_morpholog1.44770546
50MP0002933_joint_inflammation1.44766106
51MP0005671_abnormal_response_to1.42154186
52MP0002127_abnormal_cardiovascular_syste1.41805284
53MP0002277_abnormal_respiratory_mucosa1.40242674
54MP0008469_abnormal_protein_level1.36262738
55MP0001293_anophthalmia1.35501596
56MP0001853_heart_inflammation1.34695796
57MP0002722_abnormal_immune_system1.33731397
58MP0002398_abnormal_bone_marrow1.33109255
59MP0000689_abnormal_spleen_morphology1.32505101
60MP0001800_abnormal_humoral_immune1.31439896
61MP0003191_abnormal_cellular_cholesterol1.31141490
62MP0002085_abnormal_embryonic_tissue1.29568934
63MP0001348_abnormal_lacrimal_gland1.27114550
64MP0003183_abnormal_peptide_metabolism1.27087606
65MP0000313_abnormal_cell_death1.26356124
66MP0001835_abnormal_antigen_presentation1.25945619
67MP0001849_ear_inflammation1.25804325
68MP0002006_tumorigenesis1.25150461
69MP0000703_abnormal_thymus_morphology1.21506250
70MP0002132_abnormal_respiratory_system1.21342183
71MP0003786_premature_aging1.21079383
72MP0001730_embryonic_growth_arrest1.20513880
73MP0008007_abnormal_cellular_replicative1.18711392
74MP0000685_abnormal_immune_system1.18093369
75MP0002084_abnormal_developmental_patter1.17122546
76MP0002405_respiratory_system_inflammati1.16530714
77MP0003938_abnormal_ear_development1.16376000
78MP0008058_abnormal_DNA_repair1.16270122
79MP0004381_abnormal_hair_follicle1.15654997
80MP0005387_immune_system_phenotype1.14775248
81MP0001790_abnormal_immune_system1.14775248
82MP0009333_abnormal_splenocyte_physiolog1.14475793
83MP0009764_decreased_sensitivity_to1.14177678
84MP0003045_fibrosis1.12709271
85MP0001851_eye_inflammation1.12555645
86MP0002092_abnormal_eye_morphology1.11271010
87MP0000716_abnormal_immune_system1.10376930
88MP0002019_abnormal_tumor_incidence1.09267662
89MP0003123_paternal_imprinting1.08987096
90MP0002138_abnormal_hepatobiliary_system1.07602567
91MP0002429_abnormal_blood_cell1.07578646
92MP0001697_abnormal_embryo_size1.05137301
93MP0005310_abnormal_salivary_gland1.04612486
94MP0004197_abnormal_fetal_growth/weight/1.03258348
95MP0005266_abnormal_metabolism1.03001707
96MP0002998_abnormal_bone_remodeling1.02548008
97MP0002420_abnormal_adaptive_immunity1.00066430
98MP0000858_altered_metastatic_potential0.99677902
99MP0002080_prenatal_lethality0.99608608
100MP0008932_abnormal_embryonic_tissue0.99470593
101MP0002970_abnormal_white_adipose0.99412155
102MP0005000_abnormal_immune_tolerance0.98603833
103MP0002932_abnormal_joint_morphology0.98428109
104MP0001819_abnormal_immune_cell0.98294732
105MP0009763_increased_sensitivity_to0.95334623
106MP0003828_pulmonary_edema0.95090823
107MP0003787_abnormal_imprinting0.94338206
108MP0005023_abnormal_wound_healing0.92704008
109MP0008260_abnormal_autophagy0.91508322
110MP0003448_altered_tumor_morphology0.90805022
111MP0001663_abnormal_digestive_system0.89992251
112MP0002723_abnormal_immune_serum0.89615256
113MP0004133_heterotaxia0.88744836
114MP0008789_abnormal_olfactory_epithelium0.88555523
115MP0008770_decreased_survivor_rate0.87345863
116MP0003119_abnormal_digestive_system0.84400427
117MP0002452_abnormal_antigen_presenting0.84096828
118MP0003172_abnormal_lysosome_physiology0.82557773
119MP0004883_abnormal_blood_vessel0.82465265
120MP0010030_abnormal_orbit_morphology0.82196875
121MP0005166_decreased_susceptibility_to0.81491252
122MP0004808_abnormal_hematopoietic_stem0.81347481
123MP0004510_myositis0.79826849
124MP0002114_abnormal_axial_skeleton0.79295220
125MP0000432_abnormal_head_morphology0.78450281
126MP0002009_preneoplasia0.78143610
127MP0000049_abnormal_middle_ear0.77815608
128MP0002925_abnormal_cardiovascular_devel0.76097665
129MP0003436_decreased_susceptibility_to0.75573937
130MP0000428_abnormal_craniofacial_morphol0.74054274
131MP0005025_abnormal_response_to0.73811245
132MP0010155_abnormal_intestine_physiology0.72540616
133MP0000762_abnormal_tongue_morphology0.71715337
134MP0001986_abnormal_taste_sensitivity0.71630372
135MP0005390_skeleton_phenotype0.71360050
136MP0003075_altered_response_to0.68530095
137MP0008004_abnormal_stomach_pH0.68528504
138MP0009765_abnormal_xenobiotic_induced0.65906924
139MP0000604_amyloidosis0.65763980
140MP0002693_abnormal_pancreas_physiology0.65617599
141MP0000249_abnormal_blood_vessel0.64057899
142MP0005164_abnormal_response_to0.63011739
143MP0009840_abnormal_foam_cell0.60717771
144MP0005058_abnormal_lysosome_morphology0.60246742
145MP0003795_abnormal_bone_structure0.59812258
146MP0009278_abnormal_bone_marrow0.56667850
147MP0003806_abnormal_nucleotide_metabolis0.56025628
148MP0001765_abnormal_ion_homeostasis0.53210660
149MP0004130_abnormal_muscle_cell0.51347076
150MP0002136_abnormal_kidney_physiology0.51057022
151MP0005381_digestive/alimentary_phenotyp0.50841871
152MP0000343_altered_response_to0.49692571
153MP0003690_abnormal_glial_cell0.49418596
154MP0008874_decreased_physiological_sensi0.44657383
155MP0000609_abnormal_liver_physiology0.43267933
156MP0005451_abnormal_body_composition0.42768819
157MP0008873_increased_physiological_sensi0.42760000
158MP0001919_abnormal_reproductive_system0.42547344
159MP0009642_abnormal_blood_homeostasis0.41848490
160MP0005377_hearing/vestibular/ear_phenot0.39724312
161MP0003878_abnormal_ear_physiology0.39724312
162MP0003638_abnormal_response/metabolism_0.39548448
163MP0005319_abnormal_enzyme/_coenzyme0.37647933
164MP0009643_abnormal_urine_homeostasis0.35641303

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.29570385
2Abnormality of T cell number (HP:0011839)5.76722966
3Hypochromic microcytic anemia (HP:0004840)5.60067857
4Eczematoid dermatitis (HP:0000976)5.40652872
5Stomatitis (HP:0010280)5.21781790
6Myositis (HP:0100614)4.95175520
7Multiple enchondromatosis (HP:0005701)4.94385477
8Rib fusion (HP:0000902)4.69595652
9Abnormality of T cells (HP:0002843)4.58193066
10Abnormal delayed hypersensitivity skin test (HP:0002963)4.52889779
11Abnormality of macrophages (HP:0004311)4.45020526
12Orchitis (HP:0100796)4.37558486
13Optic neuritis (HP:0100653)4.36960267
14Retrobulbar optic neuritis (HP:0100654)4.36960267
15Ependymoma (HP:0002888)4.36716447
16Recurrent fungal infections (HP:0002841)4.29811207
17Recurrent bacterial skin infections (HP:0005406)4.25373559
18Recurrent abscess formation (HP:0002722)4.23090820
19Hepatoblastoma (HP:0002884)4.17389954
20IgG deficiency (HP:0004315)4.17326135
21Encephalitis (HP:0002383)4.16658613
22Abnormality of the lower motor neuron (HP:0002366)4.15074119
23Meningitis (HP:0001287)4.10293771
24Gastrointestinal infarctions (HP:0005244)4.06273247
25Chromosomal breakage induced by crosslinking agents (HP:0003221)4.03535677
26Severe combined immunodeficiency (HP:0004430)3.92326360
27Chronic mucocutaneous candidiasis (HP:0002728)3.88407160
28Recurrent cutaneous fungal infections (HP:0011370)3.88407160
29Autoimmune hemolytic anemia (HP:0001890)3.83719609
30Panhypogammaglobulinemia (HP:0003139)3.79618044
31Pustule (HP:0200039)3.75665875
32Mediastinal lymphadenopathy (HP:0100721)3.74677472
33Vasculitis (HP:0002633)3.73654760
34Chronic obstructive pulmonary disease (HP:0006510)3.68027689
35Obstructive lung disease (HP:0006536)3.68027689
36Neoplasm of striated muscle (HP:0009728)3.63023201
37Rhabdomyosarcoma (HP:0002859)3.59984372
38Chromsome breakage (HP:0040012)3.57661363
39Recurrent viral infections (HP:0004429)3.52828154
40Abnormality of eosinophils (HP:0001879)3.47890934
41Intestinal fistula (HP:0100819)3.46975292
42Nephroblastoma (Wilms tumor) (HP:0002667)3.45436307
43Rectal fistula (HP:0100590)3.41004188
44Rectovaginal fistula (HP:0000143)3.41004188
45Leukocytosis (HP:0001974)3.40294905
46Pulmonary infiltrates (HP:0002113)3.39894820
47Prolonged bleeding time (HP:0003010)3.38667811
48Lymphopenia (HP:0001888)3.34207437
49Recurrent skin infections (HP:0001581)3.33050131
50Keratoconjunctivitis sicca (HP:0001097)3.30017351
51Granulocytopenia (HP:0001913)3.28688586
52Abnormality of T cell physiology (HP:0011840)3.28100412
53Eosinophilia (HP:0001880)3.27587604
54Combined immunodeficiency (HP:0005387)3.27563017
55Agammaglobulinemia (HP:0004432)3.26358904
56Spontaneous hematomas (HP:0007420)3.24924325
57Recurrent bronchitis (HP:0002837)3.18582846
58Keratoconjunctivitis (HP:0001096)3.17148320
59Abnormality of cells of the lymphoid lineage (HP:0012140)3.16257710
60Embryonal renal neoplasm (HP:0011794)3.15287362
61Hypochromic anemia (HP:0001931)3.13059841
62Testicular atrophy (HP:0000029)3.11767694
63Chest pain (HP:0100749)3.05461961
64IgM deficiency (HP:0002850)3.04049003
65Nasal polyposis (HP:0100582)3.01877552
66Inflammation of the large intestine (HP:0002037)3.00503283
67Hemoptysis (HP:0002105)2.99413890
68Chronic diarrhea (HP:0002028)2.97961816
69Increased IgE level (HP:0003212)2.97055924
70Hypoplasia of the fovea (HP:0007750)2.94137269
71Aplasia/Hypoplasia of the fovea (HP:0008060)2.94137269
72Recurrent gram-negative bacterial infections (HP:0005420)2.93625041
73Epistaxis (HP:0000421)2.93141875
74Vaginal fistula (HP:0004320)2.92087432
75Joint swelling (HP:0001386)2.90455056
76Gastrointestinal inflammation (HP:0004386)2.88722952
77Abnormality of the astrocytes (HP:0100707)2.86204829
78Astrocytoma (HP:0009592)2.86204829
79Petechiae (HP:0000967)2.85312071
80Fused cervical vertebrae (HP:0002949)2.83163272
81Amyotrophic lateral sclerosis (HP:0007354)2.82122557
82Aplasia/hypoplasia of the humerus (HP:0006507)2.80668637
83Partial duplication of thumb phalanx (HP:0009944)2.80329535
84Short humerus (HP:0005792)2.73167486
85Abnormality of the salivary glands (HP:0010286)2.69979092
86Abnormal lung lobation (HP:0002101)2.69789866
87Hypergammaglobulinemia (HP:0010702)2.69313703
88Meckel diverticulum (HP:0002245)2.69161298
89Ragged-red muscle fibers (HP:0003200)2.66545512
90Anomalous pulmonary venous return (HP:0010772)2.66419115
91Trismus (HP:0000211)2.65774450
92Impulsivity (HP:0100710)2.62105787
93Anorexia (HP:0002039)2.61592726
94Preauricular skin tag (HP:0000384)2.61100231
95Aplasia/Hypoplasia of the uvula (HP:0010293)2.60853292
96Abnormality of the ileum (HP:0001549)2.59747317
97Urticaria (HP:0001025)2.59458257
98Pulmonary embolism (HP:0002204)2.56580834
99Abnormality of the nasal mucosa (HP:0000433)2.53495458
100Reduced antithrombin III activity (HP:0001976)2.52308020
101Gingival bleeding (HP:0000225)2.51029820
102Cheilitis (HP:0100825)2.51004200
103Gangrene (HP:0100758)2.47783752
104Abnormality of the prostate (HP:0008775)2.47597972
105Progressive muscle weakness (HP:0003323)2.46066884
106Tongue fasciculations (HP:0001308)2.45367273
107Arterial thrombosis (HP:0004420)2.44107680
108Purpura (HP:0000979)2.41856243
109Skin tags (HP:0010609)2.41647939
110Papilloma (HP:0012740)2.38682621
111Verrucae (HP:0200043)2.38682621
112Supernumerary spleens (HP:0009799)2.38426319
113Bifid tongue (HP:0010297)2.36153735
114Abnormality of the pleura (HP:0002103)2.35166169
115Horizontal nystagmus (HP:0000666)2.34852180
116Partial duplication of the phalanx of hand (HP:0009999)2.34562359
117Increased IgM level (HP:0003496)2.34440288
118Colitis (HP:0002583)2.33361995
119Hyperinsulinemic hypoglycemia (HP:0000825)2.31688046
120Lymphoma (HP:0002665)2.31424634
121Shawl scrotum (HP:0000049)2.30754167
122Gingivitis (HP:0000230)2.30502440
123Thyroiditis (HP:0100646)2.29879874
124Autoimmune thrombocytopenia (HP:0001973)2.29269202
125Hypoproteinemia (HP:0003075)2.26834172
126Abnormal cartilage morphology (HP:0002763)2.23732895
127Gastrointestinal stroma tumor (HP:0100723)2.23055079
128Abnormality of the pulmonary veins (HP:0011718)2.22072870
129Abnormality of small intestinal villus morphology (HP:0011472)2.20591144
130Villous atrophy (HP:0011473)2.20591144
131Cellulitis (HP:0100658)2.20051031
132Abnormality of B cell number (HP:0010975)2.19837683
133Acute hepatic failure (HP:0006554)2.18668012
134Premature ovarian failure (HP:0008209)2.18332166
135Medulloblastoma (HP:0002885)2.18095819
136Muscle fibrillation (HP:0010546)2.17559523
137Atrophy/Degeneration involving motor neurons (HP:0007373)2.17323870
138Keratitis (HP:0000491)2.17210266
139Microcytic anemia (HP:0001935)2.17009677
140Large earlobe (HP:0009748)2.15980631
141Elevated erythrocyte sedimentation rate (HP:0003565)2.15720019
142Glomerulopathy (HP:0100820)2.15044843
143Episodic fever (HP:0001954)2.14590392
144Glioma (HP:0009733)2.14194340
145Generalized hypotonia (HP:0001290)2.13500367
146Hypoplasia of the thymus (HP:0000778)2.13012551
147Abnormality of chromosome segregation (HP:0002916)2.12977901
148Abnormality of the fovea (HP:0000493)2.12801585
149Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.11361144
150Myelodysplasia (HP:0002863)2.09328805
151Pendular nystagmus (HP:0012043)2.07902293
152Preauricular pit (HP:0004467)2.06241786
153Periauricular skin pits (HP:0100277)2.06241786
154Skin rash (HP:0000988)2.06050311
155Small intestinal stenosis (HP:0012848)2.06035970
156Duodenal stenosis (HP:0100867)2.06035970
157Short 5th finger (HP:0009237)2.05741319
158Sepsis (HP:0100806)2.05477202
159Chronic otitis media (HP:0000389)2.03338235
160Premature loss of primary teeth (HP:0006323)2.02011649
161Recurrent sinusitis (HP:0011108)2.01316907
162Osteomyelitis (HP:0002754)2.01140338
163Pseudobulbar signs (HP:0002200)2.00932947
164IgA deficiency (HP:0002720)1.99857543
165Type I transferrin isoform profile (HP:0003642)1.99773450
166Polyneuropathy (HP:0001271)1.96854939
167Abnormality of the preputium (HP:0100587)1.96746081
168Microretrognathia (HP:0000308)1.96213381
169Abnormality of the phalanges of the hallux (HP:0010057)1.95393726
170Upper motor neuron abnormality (HP:0002127)1.95256926
171Microvesicular hepatic steatosis (HP:0001414)1.94190805
172Vertebral fusion (HP:0002948)1.93848599
173Arthralgia (HP:0002829)1.93018988
174Abnormality of the pericardium (HP:0001697)1.91283461
175Skin ulcer (HP:0200042)1.91169301
176Aplasia/Hypoplasia of the macula (HP:0008059)1.90922158
177Bronchitis (HP:0012387)1.90371098
178Abnormality of the distal phalanx of the thumb (HP:0009617)1.86233730
179Aplastic anemia (HP:0001915)1.85971680
180Missing ribs (HP:0000921)1.85416297
181Abnormality of the musculature of the hand (HP:0001421)1.84573846
182Malignant neoplasm of the central nervous system (HP:0100836)1.84066194
183Aplasia/Hypoplasia of the sacrum (HP:0008517)1.82957426
184Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.82287978
185T lymphocytopenia (HP:0005403)1.81604294
186Supernumerary ribs (HP:0005815)1.80825568
187Glossoptosis (HP:0000162)1.80776623
188Aplasia/Hypoplasia of the sternum (HP:0006714)1.80386901
189Neoplasm of the oral cavity (HP:0100649)1.78530238
190Abnormality of liposaccharide metabolism (HP:0010968)1.78139220
191Abnormality of glycosphingolipid metabolism (HP:0004343)1.78139220
192Abnormality of glycolipid metabolism (HP:0010969)1.78139220
193Fasciculations (HP:0002380)1.75776466

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.23837376
2GRK64.68310751
3GRK54.19602587
4ERN14.13809787
5RIPK43.27591334
6STK102.93421555
7ADRBK22.81289586
8CSF1R2.76846724
9FES2.72828249
10GRK12.70707244
11TGFBR22.54059281
12TYRO32.43402710
13TAOK32.28421837
14TTK2.23684785
15MATK2.11353195
16MAPK72.09992732
17IRAK42.09773117
18IKBKE2.08606970
19GRK72.00930686
20TEC1.78394231
21CDK71.78339012
22MAP3K141.75373004
23MAP4K11.73677027
24MAP3K101.67998476
25JAK11.61920908
26PRPF4B1.51552541
27SIK31.50319481
28MOS1.48666613
29LYN1.47866305
30TBK11.46255650
31MAP3K131.39366133
32FGFR31.38479313
33MAP3K111.37573099
34WNK11.37423660
35EPHA21.35533032
36MAP2K31.33514654
37HIPK21.25584927
38CHEK21.25074223
39PRKCQ1.22826383
40MARK21.21793776
41CAMK41.20551075
42PASK1.19416030
43CSK1.18484660
44EPHB11.18057996
45ITK1.16294543
46PRKG21.15514066
47PLK11.13857971
48MAP3K31.10548871
49TAOK11.07954022
50FGR1.07495858
51AKT31.06346480
52PAK41.03493534
53TLK11.02116660
54TAOK20.96866986
55NEK20.96546090
56CAMKK20.96371120
57TXK0.95919632
58JAK20.95128849
59CDC70.92789876
60ALK0.85769253
61CHEK10.85260828
62CAMKK10.84429932
63RPS6KB20.79031963
64NTRK10.78862121
65WEE10.78716263
66CDK40.78696685
67IKBKB0.75419621
68BMPR20.75163294
69PDK10.74824496
70MAP2K20.74510284
71MAP3K10.71150797
72PIM10.70986653
73FYN0.70098323
74ADRBK10.69253372
75MAP3K70.68590533
76MAP2K60.67147976
77ZAP700.67111869
78EIF2AK20.64900159
79BUB10.63212082
80PRKD20.62981701
81TESK20.61907877
82MAPK110.58848694
83CDK20.57898065
84PIK3CG0.56493929
85AKT20.55782605
86MTOR0.54538619
87JAK30.52284198
88MAPK120.50643505
89CHUK0.50028169
90LCK0.49914389
91SRPK10.48841429
92CDC42BPA0.48516760
93PRKCI0.47590926
94STK40.47461133
95MAPKAPK20.47432297
96AURKB0.46992477
97ATM0.46436884
98EPHA30.44165208
99SIK20.44036797
100BRD40.41973036
101MAP3K120.41326838
102IRAK10.41293738
103PRKCH0.40595083
104FLT30.40572781
105TESK10.39309684
106TYK20.38892811
107TNK20.38836139
108NME20.38218499
109HCK0.36928562
110LRRK20.36900948
111AURKA0.36647335
112BLK0.36528868
113ATR0.36114529
114MST40.35336300
115MAPKAPK30.34528770
116NLK0.34390488
117MAP2K40.34238826
118IGF1R0.32609193
119SYK0.31087503
120NUAK10.30608028
121PRKCD0.30469447
122EEF2K0.30105878
123DYRK30.29338392
124BMX0.28775223
125KIT0.28630732
126CLK10.28057821
127CDK10.26741126
128MAPK10.26572620
129RPS6KA40.25782457
130INSR0.25416136
131PTK2B0.25409422
132PDPK10.24661285
133MARK30.24192937
134ABL10.24040318
135KDR0.24030254
136PTK20.23929634
137MAPK140.23699144
138PTK60.23542483
139STK380.23410355
140MAPK100.22118293
141BCKDK0.21898954
142SCYL20.21120505
143SIK10.20918628
144BTK0.19189157
145PAK10.18349995
146CSNK1E0.18339356
147MELK0.18134918
148FGFR40.17995008
149MAP3K80.17966257
150MAPK40.17400710
151GSK3B0.17067614

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.17953734
2Vitamin B6 metabolism_Homo sapiens_hsa007504.15282528
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.10496236
4Primary immunodeficiency_Homo sapiens_hsa053402.75254620
5Fructose and mannose metabolism_Homo sapiens_hsa000512.65923482
6Type I diabetes mellitus_Homo sapiens_hsa049402.51660397
7DNA replication_Homo sapiens_hsa030302.36062074
8Osteoclast differentiation_Homo sapiens_hsa043802.27729317
9RNA transport_Homo sapiens_hsa030132.23352684
10Mismatch repair_Homo sapiens_hsa034302.20496269
11Ribosome_Homo sapiens_hsa030102.18176234
12Fanconi anemia pathway_Homo sapiens_hsa034601.96668249
13Staphylococcus aureus infection_Homo sapiens_hsa051501.93558079
14Galactose metabolism_Homo sapiens_hsa000521.92762789
15mRNA surveillance pathway_Homo sapiens_hsa030151.80823578
16Spliceosome_Homo sapiens_hsa030401.79879829
17Base excision repair_Homo sapiens_hsa034101.74665258
18Homologous recombination_Homo sapiens_hsa034401.73126569
19Asthma_Homo sapiens_hsa053101.72605089
20Arachidonic acid metabolism_Homo sapiens_hsa005901.71099458
21Malaria_Homo sapiens_hsa051441.64762215
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.63262632
23Cell cycle_Homo sapiens_hsa041101.60242585
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.59164730
25Chemokine signaling pathway_Homo sapiens_hsa040621.53803224
26One carbon pool by folate_Homo sapiens_hsa006701.48837156
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.48075725
28Thyroid cancer_Homo sapiens_hsa052161.46170689
29RNA degradation_Homo sapiens_hsa030181.46144228
30Herpes simplex infection_Homo sapiens_hsa051681.44837828
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.43815939
32RNA polymerase_Homo sapiens_hsa030201.39681132
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.38968144
34T cell receptor signaling pathway_Homo sapiens_hsa046601.37841940
35p53 signaling pathway_Homo sapiens_hsa041151.36892395
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36360832
37Tuberculosis_Homo sapiens_hsa051521.35538190
38mTOR signaling pathway_Homo sapiens_hsa041501.33436549
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.33411221
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.29773262
41Rheumatoid arthritis_Homo sapiens_hsa053231.27053776
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.25773757
43Linoleic acid metabolism_Homo sapiens_hsa005911.23967504
44Toxoplasmosis_Homo sapiens_hsa051451.21711998
45TNF signaling pathway_Homo sapiens_hsa046681.21318288
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.20517025
47Acute myeloid leukemia_Homo sapiens_hsa052211.17525121
48Other glycan degradation_Homo sapiens_hsa005111.16893339
49Platelet activation_Homo sapiens_hsa046111.12344169
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10679174
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10130251
52Shigellosis_Homo sapiens_hsa051311.09465794
53Antigen processing and presentation_Homo sapiens_hsa046121.07808478
54Basal transcription factors_Homo sapiens_hsa030221.07268444
55Non-homologous end-joining_Homo sapiens_hsa034501.05876030
56Nucleotide excision repair_Homo sapiens_hsa034201.03437400
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.98554445
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.97540861
59Hematopoietic cell lineage_Homo sapiens_hsa046400.95573388
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95231821
61Measles_Homo sapiens_hsa051620.95184329
62Notch signaling pathway_Homo sapiens_hsa043300.93089581
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92879323
64B cell receptor signaling pathway_Homo sapiens_hsa046620.88226515
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86443141
66Apoptosis_Homo sapiens_hsa042100.78765141
67Inositol phosphate metabolism_Homo sapiens_hsa005620.78567474
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78051816
69Pyrimidine metabolism_Homo sapiens_hsa002400.76697200
70Sulfur relay system_Homo sapiens_hsa041220.76498322
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74994936
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74596770
73HTLV-I infection_Homo sapiens_hsa051660.73293284
74MicroRNAs in cancer_Homo sapiens_hsa052060.72613107
75Hepatitis C_Homo sapiens_hsa051600.72088900
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.71720608
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71431847
78Endocytosis_Homo sapiens_hsa041440.71317119
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70759989
80Phagosome_Homo sapiens_hsa041450.68534070
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.67958722
82Pathways in cancer_Homo sapiens_hsa052000.67417267
83Salmonella infection_Homo sapiens_hsa051320.66980353
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.66206405
85Pertussis_Homo sapiens_hsa051330.65861444
86Viral carcinogenesis_Homo sapiens_hsa052030.65825023
87Leishmaniasis_Homo sapiens_hsa051400.62649133
88Allograft rejection_Homo sapiens_hsa053300.60115275
89Pentose phosphate pathway_Homo sapiens_hsa000300.59423308
90Influenza A_Homo sapiens_hsa051640.59039981
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57388251
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.56650494
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54954434
94Non-small cell lung cancer_Homo sapiens_hsa052230.53747283
95Colorectal cancer_Homo sapiens_hsa052100.53518310
96Choline metabolism in cancer_Homo sapiens_hsa052310.53295590
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.50957556
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50470180
99Pancreatic cancer_Homo sapiens_hsa052120.48860696
100Basal cell carcinoma_Homo sapiens_hsa052170.45938235
101Folate biosynthesis_Homo sapiens_hsa007900.45628669
102African trypanosomiasis_Homo sapiens_hsa051430.45108796
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43795453
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43460622
105Epstein-Barr virus infection_Homo sapiens_hsa051690.42695586
106Proteasome_Homo sapiens_hsa030500.42195727
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42156339
108Rap1 signaling pathway_Homo sapiens_hsa040150.42073630
109Small cell lung cancer_Homo sapiens_hsa052220.41254306
110VEGF signaling pathway_Homo sapiens_hsa043700.40993304
111Graft-versus-host disease_Homo sapiens_hsa053320.40551885
112MAPK signaling pathway_Homo sapiens_hsa040100.40250919
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38691016
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.37859594
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36599277
116Systemic lupus erythematosus_Homo sapiens_hsa053220.36052980
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.35482223
118Hepatitis B_Homo sapiens_hsa051610.35344638
119Prolactin signaling pathway_Homo sapiens_hsa049170.35297375
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33971719
121Chronic myeloid leukemia_Homo sapiens_hsa052200.33839388
122Regulation of autophagy_Homo sapiens_hsa041400.33584095
123Legionellosis_Homo sapiens_hsa051340.33130052
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31782674
125Renal cell carcinoma_Homo sapiens_hsa052110.30426274
126Autoimmune thyroid disease_Homo sapiens_hsa053200.29248435
127Viral myocarditis_Homo sapiens_hsa054160.28925565
128FoxO signaling pathway_Homo sapiens_hsa040680.28421786
129Adherens junction_Homo sapiens_hsa045200.28408183
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.28039951
131Hippo signaling pathway_Homo sapiens_hsa043900.27896420
132Lysine degradation_Homo sapiens_hsa003100.27667490
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27310868
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.26777477
135Lysosome_Homo sapiens_hsa041420.25621209
136Ras signaling pathway_Homo sapiens_hsa040140.23780163
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23367065
138AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.18403923
139Insulin resistance_Homo sapiens_hsa049310.18082686
140Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.10855551
141HIF-1 signaling pathway_Homo sapiens_hsa040660.10329866
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.10235711
143Endometrial cancer_Homo sapiens_hsa052130.10098629
144Glycerolipid metabolism_Homo sapiens_hsa005610.08874717

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