PCGF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: PCGF1 is a mammalian homolog of the Drosophila polycomb group genes, which act as transcriptional repressors to regulate anterior-posterior patterning in early embryonic development (Nunes et al., 2001 [PubMed 11287196]). See also PCGF2 (MIM 600346). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)7.10708274
2piRNA metabolic process (GO:0034587)6.93905448
3regulation of female gonad development (GO:2000194)6.34064480
4attachment of spindle microtubules to kinetochore (GO:0008608)6.24189379
5metaphase plate congression (GO:0051310)5.71561704
6protein K6-linked ubiquitination (GO:0085020)5.26324962
7establishment of chromosome localization (GO:0051303)5.16568587
8regulation of exit from mitosis (GO:0007096)4.85810931
9regulation of spindle organization (GO:0090224)4.84654363
10mitotic chromosome condensation (GO:0007076)4.81784572
11pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.72473736
12protein localization to kinetochore (GO:0034501)4.71039075
13oocyte maturation (GO:0001556)4.65369448
14negative regulation of meiosis (GO:0045835)4.64284112
15meiotic cell cycle (GO:0051321)4.60103496
16base-excision repair, AP site formation (GO:0006285)4.56144514
17maturation of 5.8S rRNA (GO:0000460)4.54613440
18female gamete generation (GO:0007292)4.51897754
19CENP-A containing nucleosome assembly (GO:0034080)4.50507139
20protein localization to chromosome, centromeric region (GO:0071459)4.47633792
21DNA replication checkpoint (GO:0000076)4.45250292
22regulation of DNA methylation (GO:0044030)4.38612560
23positive regulation of chromosome segregation (GO:0051984)4.27553349
24regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.24967021
25chromatin remodeling at centromere (GO:0031055)4.24202985
26mitotic sister chromatid segregation (GO:0000070)4.23595420
27regulation of meiosis (GO:0040020)4.22659718
28DNA methylation involved in gamete generation (GO:0043046)4.22570347
29regulation of sister chromatid cohesion (GO:0007063)4.20639143
30male meiosis (GO:0007140)4.18867944
31histone exchange (GO:0043486)4.11432664
32response to pheromone (GO:0019236)4.11421841
33regulation of mitotic spindle organization (GO:0060236)4.10149435
34mitochondrial respiratory chain complex I assembly (GO:0032981)4.08794638
35NADH dehydrogenase complex assembly (GO:0010257)4.08794638
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.08794638
37chaperone-mediated protein transport (GO:0072321)4.01188636
38respiratory chain complex IV assembly (GO:0008535)4.00833854
39pseudouridine synthesis (GO:0001522)3.97519772
40pyrimidine nucleotide catabolic process (GO:0006244)3.92195188
41multicellular organism reproduction (GO:0032504)3.92083117
42DNA replication-independent nucleosome assembly (GO:0006336)3.91751989
43DNA replication-independent nucleosome organization (GO:0034724)3.91751989
44meiotic chromosome segregation (GO:0045132)3.90871128
45spindle checkpoint (GO:0031577)3.90039183
46protein complex biogenesis (GO:0070271)3.86900373
47rRNA modification (GO:0000154)3.83886470
48chromosome segregation (GO:0007059)3.83513846
49protein localization to chromosome (GO:0034502)3.77637722
50cullin deneddylation (GO:0010388)3.77605698
51negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.77464133
52mitotic nuclear envelope disassembly (GO:0007077)3.76871820
537-methylguanosine mRNA capping (GO:0006370)3.72035433
54regulation of chromosome segregation (GO:0051983)3.71691254
55energy coupled proton transport, down electrochemical gradient (GO:0015985)3.69907005
56ATP synthesis coupled proton transport (GO:0015986)3.69907005
57positive regulation of mitotic sister chromatid separation (GO:1901970)3.68654804
58positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.68654804
59positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.68654804
60regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.68535311
61negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.64799089
62nucleotide transmembrane transport (GO:1901679)3.61548487
63rRNA methylation (GO:0031167)3.61534124
64regulation of hexokinase activity (GO:1903299)3.61026431
65regulation of glucokinase activity (GO:0033131)3.61026431
66RNA capping (GO:0036260)3.59829170
677-methylguanosine RNA capping (GO:0009452)3.59829170
68mitochondrial respiratory chain complex assembly (GO:0033108)3.58689666
69regulation of meiosis I (GO:0060631)3.55569556
70membrane disassembly (GO:0030397)3.51855565
71nuclear envelope disassembly (GO:0051081)3.51855565
72kinetochore assembly (GO:0051382)3.51039468
73ribosome assembly (GO:0042255)3.47748718
74negative regulation of DNA-templated transcription, elongation (GO:0032785)3.46249389
75negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.46249389
76proteasome assembly (GO:0043248)3.45239498
77maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.44834695
78mitotic spindle checkpoint (GO:0071174)3.44534873
79negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.44051482
80cytochrome complex assembly (GO:0017004)3.41420702
81negative regulation of meiotic cell cycle (GO:0051447)3.40554283
82negative regulation of chromosome segregation (GO:0051985)3.40117805
83negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.39164684
84negative regulation of sister chromatid segregation (GO:0033046)3.39164684
85negative regulation of mitotic sister chromatid separation (GO:2000816)3.39164684
86negative regulation of mitotic sister chromatid segregation (GO:0033048)3.39164684
87protein deneddylation (GO:0000338)3.39072027
88regulation of mitotic metaphase/anaphase transition (GO:0030071)3.38935064
89sister chromatid segregation (GO:0000819)3.38148835
90protein-cofactor linkage (GO:0018065)3.36801168
91synaptonemal complex assembly (GO:0007130)3.36435370
92platelet dense granule organization (GO:0060155)3.36336261
93anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.35996970
94DNA damage induced protein phosphorylation (GO:0006975)3.34510447
95mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.33442387
96transcription elongation from RNA polymerase II promoter (GO:0006368)3.31859180
97meiotic cell cycle process (GO:1903046)3.31764972
98mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.30832039
99mitotic spindle assembly checkpoint (GO:0007094)3.28926274
100regulation of sister chromatid segregation (GO:0033045)3.28219112
101regulation of mitotic sister chromatid separation (GO:0010965)3.28219112
102regulation of mitotic sister chromatid segregation (GO:0033047)3.28219112
103pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.26582195
104kinetochore organization (GO:0051383)3.24851608
105spindle assembly checkpoint (GO:0071173)3.24488758
106regulation of meiotic cell cycle (GO:0051445)3.22220974
107reciprocal DNA recombination (GO:0035825)3.19413693
108reciprocal meiotic recombination (GO:0007131)3.19413693
109oxidative demethylation (GO:0070989)3.19003356
110negative regulation of cell division (GO:0051782)3.17772322
111centriole replication (GO:0007099)3.16322587
112transcription elongation from RNA polymerase I promoter (GO:0006362)3.15581843
113protein K11-linked ubiquitination (GO:0070979)3.14790549
114microtubule depolymerization (GO:0007019)3.14575781
115synaptonemal complex organization (GO:0070193)3.12465116
116resolution of meiotic recombination intermediates (GO:0000712)3.11986108
117replication fork processing (GO:0031297)3.11116849
118misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.09741660
119peptidyl-histidine modification (GO:0018202)3.09455308
120retinal cone cell development (GO:0046549)3.09408691
121regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.08968122
122regulation of double-strand break repair via homologous recombination (GO:0010569)3.08900737
123DNA deamination (GO:0045006)3.08372294
124negative regulation of nuclear division (GO:0051784)3.07654988
125transcription elongation from RNA polymerase III promoter (GO:0006385)3.06285208
126termination of RNA polymerase III transcription (GO:0006386)3.06285208
127establishment of protein localization to mitochondrial membrane (GO:0090151)3.05829020
128gene silencing by RNA (GO:0031047)3.04570985
129meiosis I (GO:0007127)3.03860909
130meiotic nuclear division (GO:0007126)3.03168831
131L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.99739153
132negative regulation of organelle assembly (GO:1902116)2.98600995
133termination of RNA polymerase I transcription (GO:0006363)2.96578358
134DNA-dependent DNA replication (GO:0006261)2.93921815
135secondary metabolite biosynthetic process (GO:0044550)2.91364364
136tRNA processing (GO:0008033)2.90130305
137RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.89042265
138tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.89042265
139protein polyglutamylation (GO:0018095)2.88789229
140pyrimidine dimer repair (GO:0006290)2.88577279
141nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.88465411
142mannosylation (GO:0097502)2.87909965
143electron transport chain (GO:0022900)2.87764413
144respiratory electron transport chain (GO:0022904)2.87204501
145positive regulation of DNA recombination (GO:0045911)2.84982148
146sperm-egg recognition (GO:0035036)2.84149766
147negative regulation of telomere maintenance (GO:0032205)2.80905431
148male meiosis I (GO:0007141)2.80473537
149exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.78184236
150tRNA modification (GO:0006400)2.74109756
151DNA catabolic process, exonucleolytic (GO:0000738)2.73062784
152anterograde synaptic vesicle transport (GO:0048490)2.72810590
153negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.71821991
154tRNA methylation (GO:0030488)2.71600359
155positive regulation of isotype switching (GO:0045830)2.71054320
156somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.67913739
157isotype switching (GO:0045190)2.67913739
158somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.67913739
159positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.67717087
160binding of sperm to zona pellucida (GO:0007339)2.64270801
161regulation of microtubule-based movement (GO:0060632)2.62794433
162ubiquinone biosynthetic process (GO:0006744)2.62640982
163exogenous drug catabolic process (GO:0042738)2.62426240
164mismatch repair (GO:0006298)2.62008923
165tRNA metabolic process (GO:0006399)2.59829305
166sperm motility (GO:0030317)2.59413752
167positive regulation of gastrulation (GO:2000543)2.58851418
168DNA double-strand break processing (GO:0000729)2.57380678
169intracellular protein transmembrane import (GO:0044743)2.57342714
170centriole assembly (GO:0098534)2.57338751
171transcription from mitochondrial promoter (GO:0006390)2.54387483
172cellular respiration (GO:0045333)2.53825484
173regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.53420724
174preassembly of GPI anchor in ER membrane (GO:0016254)2.53162698
175regulation of cellular amino acid metabolic process (GO:0006521)2.53159440
176acrosome reaction (GO:0007340)2.52890544
177anterograde axon cargo transport (GO:0008089)2.52553682
178GTP biosynthetic process (GO:0006183)2.51792320
179DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.50000275
180epithelial cilium movement (GO:0003351)2.49471541

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.77615695
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.70008119
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.39616559
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.92167346
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.80289347
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.65835577
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.39011602
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.35308175
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.32659243
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.11737387
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.96917826
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.93169122
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.86844261
14AR_21909140_ChIP-Seq_LNCAP_Human2.83774920
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.82497201
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.80463708
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.73137404
18ZNF274_21170338_ChIP-Seq_K562_Hela2.53636886
19KAP1_22055183_ChIP-Seq_ESCs_Mouse2.51733735
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.41346626
21EZH2_22144423_ChIP-Seq_EOC_Human2.38649777
22GABP_19822575_ChIP-Seq_HepG2_Human2.33095095
23* VDR_23849224_ChIP-Seq_CD4+_Human2.27818771
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.27472377
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24751437
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.23744990
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.16366228
28CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.03501570
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00688555
30MYC_19030024_ChIP-ChIP_MESCs_Mouse2.00547537
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.98311814
32* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94263754
33FOXP3_21729870_ChIP-Seq_TREG_Human1.93932022
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.93293890
35* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.90474562
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89107276
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.87906737
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.87349430
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.80562831
40* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.78884657
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.78286341
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.77323729
43XRN2_22483619_ChIP-Seq_HELA_Human1.74872179
44DCP1A_22483619_ChIP-Seq_HELA_Human1.69280345
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65778839
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.62910368
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55925224
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55268891
49MYC_18940864_ChIP-ChIP_HL60_Human1.54668806
50KDM5A_27292631_Chip-Seq_BREAST_Human1.54575777
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54530027
52NANOG_20526341_ChIP-Seq_ESCs_Human1.54315997
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52104401
54TTF2_22483619_ChIP-Seq_HELA_Human1.48447209
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47378380
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45879224
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.44875264
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44514852
59CIITA_25753668_ChIP-Seq_RAJI_Human1.37277682
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.36029783
61E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.34990232
62TP53_22573176_ChIP-Seq_HFKS_Human1.34737419
63* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.34681399
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32165839
65GATA3_21878914_ChIP-Seq_MCF-7_Human1.28859188
66NANOG_21062744_ChIP-ChIP_HESCs_Human1.27847212
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26657833
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26260872
69* TAF2_19829295_ChIP-Seq_ESCs_Human1.26119470
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.25713629
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.25457942
72ERA_21632823_ChIP-Seq_H3396_Human1.24886406
73* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22543691
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.22145989
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21420961
76ELK1_19687146_ChIP-ChIP_HELA_Human1.20020096
77* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19736976
78CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19328423
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17418085
80EWS_26573619_Chip-Seq_HEK293_Human1.17109194
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.16306559
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16306559
83NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16069480
84RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.13409937
85DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13371182
86* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12393267
87NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12376877
88MYC_19829295_ChIP-Seq_ESCs_Human1.09962768
89EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09733904
90HOXB7_26014856_ChIP-Seq_BT474_Human1.09279569
91SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08360553
92* YY1_22570637_ChIP-Seq_MALME-3M_Human1.07969061
93AR_20517297_ChIP-Seq_VCAP_Human1.07100178
94* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.06235425
95FLI1_27457419_Chip-Seq_LIVER_Mouse1.05853213
96P53_21459846_ChIP-Seq_SAOS-2_Human1.05468228
97EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04565516
98* BCL6_27268052_Chip-Seq_Bcells_Human1.04214817
99* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03965085
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00961246
101PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00588091
102CTCF_20526341_ChIP-Seq_ESCs_Human0.99112668
103IRF1_19129219_ChIP-ChIP_H3396_Human0.98728225
104HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97684854
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97126340
106CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96551543
107ELF1_20517297_ChIP-Seq_JURKAT_Human0.94799921
108VDR_22108803_ChIP-Seq_LS180_Human0.94681533
109BP1_19119308_ChIP-ChIP_Hs578T_Human0.94238983
110FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93732652
111FUS_26573619_Chip-Seq_HEK293_Human0.93228637
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92577864
113* FOXP1_21924763_ChIP-Seq_HESCs_Human0.92337007
114CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92138451
115NANOG_19829295_ChIP-Seq_ESCs_Human0.90786879
116SOX2_19829295_ChIP-Seq_ESCs_Human0.90786879
117ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90524592
118SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90228136
119ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.89655109
120GATA1_26923725_Chip-Seq_HPCs_Mouse0.88586038
121SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88519106
122FOXH1_21741376_ChIP-Seq_EPCs_Human0.88397647
123ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88034946
124BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87770911
125GATA3_21867929_ChIP-Seq_TH1_Mouse0.87732078
126ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86610365
127* PHF8_20622854_ChIP-Seq_HELA_Human0.86373385
128NCOR_22424771_ChIP-Seq_293T_Human0.86366278
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86260046
130RAC3_21632823_ChIP-Seq_H3396_Human0.86116117
131POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85851319
132PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85799495
133TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.85351957
134IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85208307
135CBP_20019798_ChIP-Seq_JUKART_Human0.85208307
136* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85165716
137PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84999341
138E2F1_20622854_ChIP-Seq_HELA_Human0.83047136
139RUNX1_26923725_Chip-Seq_HPCs_Mouse0.82086225
140PU.1_20513432_ChIP-Seq_Bcells_Mouse0.76955799
141* ELK1_22589737_ChIP-Seq_MCF10A_Human0.76136812
142* STAT1_17558387_ChIP-Seq_HELA_Human0.74661821
143LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74216086
144SMAD_19615063_ChIP-ChIP_OVARY_Human0.72884879
145GATA3_21867929_ChIP-Seq_CD8_Mouse0.69463068
146ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.68432299
147ERG_20517297_ChIP-Seq_VCAP_Human0.67626948
148* KAP1_27257070_Chip-Seq_ESCs_Mouse0.66942713
149LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.66754450
150CTCF_26484167_Chip-Seq_Bcells_Mouse0.64899844
151FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.64602874
152POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.64295293

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect6.57727884
2MP0003693_abnormal_embryo_hatching5.89199750
3MP0008877_abnormal_DNA_methylation4.75325896
4MP0010094_abnormal_chromosome_stability4.17199379
5MP0003111_abnormal_nucleus_morphology3.95800507
6MP0003646_muscle_fatigue3.91712226
7MP0004957_abnormal_blastocyst_morpholog3.82588491
8MP0003077_abnormal_cell_cycle3.76774487
9MP0005451_abnormal_body_composition3.13017866
10MP0008875_abnormal_xenobiotic_pharmacok3.06517313
11MP0005410_abnormal_fertilization2.98510307
12MP0002132_abnormal_respiratory_system2.86719701
13MP0005395_other_phenotype2.52277861
14MP0008058_abnormal_DNA_repair2.48632245
15MP0003787_abnormal_imprinting2.45762128
16MP0001929_abnormal_gametogenesis2.43712500
17MP0001119_abnormal_female_reproductive2.41729685
18MP0008007_abnormal_cellular_replicative2.39387008
19MP0003699_abnormal_female_reproductive2.37143661
20MP0002210_abnormal_sex_determination2.29215174
21MP0003315_abnormal_perineum_morphology2.25911580
22MP0008932_abnormal_embryonic_tissue2.24179395
23MP0004147_increased_porphyrin_level2.22399002
24MP0003195_calcinosis2.21303798
25MP0006292_abnormal_olfactory_placode2.16673792
26MP0000653_abnormal_sex_gland2.14024051
27MP0003950_abnormal_plasma_membrane1.96488828
28MP0008789_abnormal_olfactory_epithelium1.96031894
29MP0008260_abnormal_autophagy1.91799346
30MP0005646_abnormal_pituitary_gland1.91534111
31MP0002653_abnormal_ependyma_morphology1.90621839
32MP0002254_reproductive_system_inflammat1.88771482
33MP0008872_abnormal_physiological_respon1.88381131
34MP0003123_paternal_imprinting1.85015935
35MP0008057_abnormal_DNA_replication1.70488243
36MP0004142_abnormal_muscle_tone1.69574138
37MP0006082_CNS_inflammation1.69553285
38MP0003136_yellow_coat_color1.65765382
39MP0001730_embryonic_growth_arrest1.64624464
40MP0001145_abnormal_male_reproductive1.64584555
41MP0003786_premature_aging1.64343380
42MP0000350_abnormal_cell_proliferation1.63012165
43MP0005075_abnormal_melanosome_morpholog1.62443301
44MP0004133_heterotaxia1.59803284
45MP0003121_genomic_imprinting1.58077839
46MP0001905_abnormal_dopamine_level1.54418256
47MP0002138_abnormal_hepatobiliary_system1.53755843
48MP0001529_abnormal_vocalization1.52958712
49MP0003011_delayed_dark_adaptation1.52618829
50MP0010386_abnormal_urinary_bladder1.47604991
51MP0005408_hypopigmentation1.45693375
52MP0002161_abnormal_fertility/fecundity1.44291410
53MP0005083_abnormal_biliary_tract1.38218363
54MP0005551_abnormal_eye_electrophysiolog1.38126346
55MP0005167_abnormal_blood-brain_barrier1.36415427
56MP0005499_abnormal_olfactory_system1.34474812
57MP0005394_taste/olfaction_phenotype1.34474812
58MP0002396_abnormal_hematopoietic_system1.33929378
59MP0005187_abnormal_penis_morphology1.33096185
60MP0002837_dystrophic_cardiac_calcinosis1.32606886
61MP0002277_abnormal_respiratory_mucosa1.27066060
62MP0002102_abnormal_ear_morphology1.24234201
63MP0005253_abnormal_eye_physiology1.22337226
64MP0002019_abnormal_tumor_incidence1.20692793
65MP0000579_abnormal_nail_morphology1.19935036
66MP0006035_abnormal_mitochondrial_morpho1.19481255
67MP0003763_abnormal_thymus_physiology1.17191280
68MP0001348_abnormal_lacrimal_gland1.15385105
69MP0005380_embryogenesis_phenotype1.15032100
70MP0001672_abnormal_embryogenesis/_devel1.15032100
71MP0002876_abnormal_thyroid_physiology1.13764357
72MP0003937_abnormal_limbs/digits/tail_de1.12103761
73MP0002085_abnormal_embryonic_tissue1.11881574
74MP0001697_abnormal_embryo_size1.10611383
75MP0003656_abnormal_erythrocyte_physiolo1.10217974
76MP0005389_reproductive_system_phenotype1.08885457
77MP0009697_abnormal_copulation1.06338612
78MP0002160_abnormal_reproductive_system1.05462426
79MP0001324_abnormal_eye_pigmentation1.04418566
80MP0005360_urolithiasis1.02950466
81MP0001873_stomach_inflammation1.02242545
82MP0009046_muscle_twitch1.01301212
83MP0003698_abnormal_male_reproductive1.01084475
84MP0005257_abnormal_intraocular_pressure1.00220582
85MP0000631_abnormal_neuroendocrine_gland0.99822855
86MP0001764_abnormal_homeostasis0.99110180
87MP0002080_prenatal_lethality0.95808485
88MP0002234_abnormal_pharynx_morphology0.95745590
89MP0010307_abnormal_tumor_latency0.94837095
90MP0009333_abnormal_splenocyte_physiolog0.93436879
91MP0002163_abnormal_gland_morphology0.91630537
92MP0009785_altered_susceptibility_to0.90176045
93MP0000313_abnormal_cell_death0.89609622
94MP0000372_irregular_coat_pigmentation0.89299028
95MP0000490_abnormal_crypts_of0.89295501
96MP0001756_abnormal_urination0.88831292
97MP0005621_abnormal_cell_physiology0.88067218
98MP0000427_abnormal_hair_cycle0.86517288
99MP0002822_catalepsy0.84583575
100MP0002638_abnormal_pupillary_reflex0.83747924
101MP0010030_abnormal_orbit_morphology0.83494765
102MP0004264_abnormal_extraembryonic_tissu0.83173650
103MP0005397_hematopoietic_system_phenotyp0.82534542
104MP0001545_abnormal_hematopoietic_system0.82534542
105MP0002084_abnormal_developmental_patter0.80521410
106MP0001919_abnormal_reproductive_system0.79610014
107MP0004043_abnormal_pH_regulation0.78535238
108MP0005384_cellular_phenotype0.77543346
109MP0000639_abnormal_adrenal_gland0.75717569
110MP0003984_embryonic_growth_retardation0.74576763
111MP0005084_abnormal_gallbladder_morpholo0.74311916
112MP0005332_abnormal_amino_acid0.74191144
113MP0005310_abnormal_salivary_gland0.74040990
114MP0006036_abnormal_mitochondrial_physio0.73310918
115MP0003119_abnormal_digestive_system0.72817106
116MP0000015_abnormal_ear_pigmentation0.72741019
117MP0008775_abnormal_heart_ventricle0.71381135
118MP0000749_muscle_degeneration0.71327001
119MP0002088_abnormal_embryonic_growth/wei0.70429957
120MP0002272_abnormal_nervous_system0.70258239
121MP0002877_abnormal_melanocyte_morpholog0.69782546
122MP0005671_abnormal_response_to0.69504502
123MP0001984_abnormal_olfaction0.69493524
124MP0000689_abnormal_spleen_morphology0.66436386
125MP0005266_abnormal_metabolism0.65543173
126MP0002269_muscular_atrophy0.64230447
127MP0002751_abnormal_autonomic_nervous0.64080842
128MP0005174_abnormal_tail_pigmentation0.63298631
129MP0000678_abnormal_parathyroid_gland0.63256973
130MP0009840_abnormal_foam_cell0.62509239
131MP0000538_abnormal_urinary_bladder0.62271484
132MP0002249_abnormal_larynx_morphology0.61885192
133MP0003879_abnormal_hair_cell0.59023900
134MP0002398_abnormal_bone_marrow0.57434493
135MP0003186_abnormal_redox_activity0.57084367
136MP0000613_abnormal_salivary_gland0.55729757
137MP0008995_early_reproductive_senescence0.55072499
138MP0005379_endocrine/exocrine_gland_phen0.52999334
139MP0000703_abnormal_thymus_morphology0.52297555
140MP0002086_abnormal_extraembryonic_tissu0.51504721
141MP0000358_abnormal_cell_content/0.51218645
142MP0003806_abnormal_nucleotide_metabolis0.48436292
143MP0002127_abnormal_cardiovascular_syste0.48426608
144MP0002095_abnormal_skin_pigmentation0.48336047
145MP0004782_abnormal_surfactant_physiolog0.48033656
146MP0002722_abnormal_immune_system0.47775592
147MP0005220_abnormal_exocrine_pancreas0.45453782
148MP0001986_abnormal_taste_sensitivity0.45302325
149MP0004808_abnormal_hematopoietic_stem0.42296475
150MP0006072_abnormal_retinal_apoptosis0.39471325

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)7.40771870
2Birth length less than 3rd percentile (HP:0003561)6.52742822
3Breast hypoplasia (HP:0003187)5.66353470
4Premature ovarian failure (HP:0008209)4.85529317
5Patellar aplasia (HP:0006443)4.53248563
6Impulsivity (HP:0100710)4.37820397
7Chromsome breakage (HP:0040012)4.36181406
8Infertility (HP:0000789)4.30073019
9Aplasia/Hypoplasia of the patella (HP:0006498)4.19319671
10Chromosomal breakage induced by crosslinking agents (HP:0003221)4.14094743
11Secondary amenorrhea (HP:0000869)4.07248702
12Papillary thyroid carcinoma (HP:0002895)3.80864831
13Abnormality of the labia minora (HP:0012880)3.76702861
143-Methylglutaconic aciduria (HP:0003535)3.71567190
15Cortical dysplasia (HP:0002539)3.48485189
16Attenuation of retinal blood vessels (HP:0007843)3.47615117
17Hepatic necrosis (HP:0002605)3.45181571
18Mitochondrial inheritance (HP:0001427)3.41929306
19Hepatocellular necrosis (HP:0001404)3.41918995
20Flat capital femoral epiphysis (HP:0003370)3.40568782
21Aplastic anemia (HP:0001915)3.31129253
22Increased CSF lactate (HP:0002490)3.28167041
23Acute encephalopathy (HP:0006846)3.22308275
24Breast aplasia (HP:0100783)3.21671928
25Aplasia/Hypoplasia of the breasts (HP:0010311)3.18442057
26Acute necrotizing encephalopathy (HP:0006965)3.11561647
27Oral leukoplakia (HP:0002745)3.10767520
28Cerebral hypomyelination (HP:0006808)3.09517065
29Pancreatic fibrosis (HP:0100732)3.04947139
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.02941870
31Dyschromatopsia (HP:0007641)3.01624107
32Abnormality of the preputium (HP:0100587)2.99969173
33Carpal bone hypoplasia (HP:0001498)2.98954829
34Renal Fanconi syndrome (HP:0001994)2.98166625
35Abnormality of chromosome stability (HP:0003220)2.98026971
36Facial hemangioma (HP:0000329)2.91354841
37Type 2 muscle fiber atrophy (HP:0003554)2.90675534
38Increased hepatocellular lipid droplets (HP:0006565)2.87786594
39Abnormal spermatogenesis (HP:0008669)2.84687388
40Meckel diverticulum (HP:0002245)2.84383239
41Pulmonary fibrosis (HP:0002206)2.76798587
42Aplasia/Hypoplasia of the uvula (HP:0010293)2.76008331
43Abnormal mitochondria in muscle tissue (HP:0008316)2.72590804
44Muscle fiber atrophy (HP:0100295)2.72151961
45Lipid accumulation in hepatocytes (HP:0006561)2.70631219
46Increased serum lactate (HP:0002151)2.69545330
47Horizontal nystagmus (HP:0000666)2.68085945
48Optic disc pallor (HP:0000543)2.67942752
49Abnormality of the ileum (HP:0001549)2.65730574
50Microretrognathia (HP:0000308)2.64654591
51Thyroid carcinoma (HP:0002890)2.64164664
52Degeneration of anterior horn cells (HP:0002398)2.60159559
53Abnormality of the anterior horn cell (HP:0006802)2.60159559
54Duodenal stenosis (HP:0100867)2.56739935
55Small intestinal stenosis (HP:0012848)2.56739935
56Congenital stationary night blindness (HP:0007642)2.56090077
57Supernumerary spleens (HP:0009799)2.54089053
58Hypergonadotropic hypogonadism (HP:0000815)2.53914371
59Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.52412537
60Abnormal rod and cone electroretinograms (HP:0008323)2.51526652
61Capillary hemangiomas (HP:0005306)2.47067011
62Methylmalonic acidemia (HP:0002912)2.46427703
63Generalized aminoaciduria (HP:0002909)2.46217602
64Progressive macrocephaly (HP:0004481)2.46216451
65Myelodysplasia (HP:0002863)2.46175454
66Severe visual impairment (HP:0001141)2.43833038
67Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.43373611
68Exertional dyspnea (HP:0002875)2.43002540
69Sloping forehead (HP:0000340)2.41833079
70Abnormality of midbrain morphology (HP:0002418)2.41715483
71Molar tooth sign on MRI (HP:0002419)2.41715483
72Pancreatic cysts (HP:0001737)2.41022164
73Shawl scrotum (HP:0000049)2.39999115
74Insulin-resistant diabetes mellitus (HP:0000831)2.38143148
75Pendular nystagmus (HP:0012043)2.35678272
76Lactic acidosis (HP:0003128)2.35139881
77Unsteady gait (HP:0002317)2.33796825
78Decreased activity of mitochondrial respiratory chain (HP:0008972)2.33315542
79Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.33315542
80Hyperglycinemia (HP:0002154)2.31755333
81Adrenal hypoplasia (HP:0000835)2.29513539
82CNS hypomyelination (HP:0003429)2.28603479
83Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.27578350
84Abnormality of the renal cortex (HP:0011035)2.26762716
85Nephronophthisis (HP:0000090)2.25350602
86Rough bone trabeculation (HP:0100670)2.23210504
87Progressive microcephaly (HP:0000253)2.22477974
88Abnormality of lateral ventricle (HP:0030047)2.21852730
89Azoospermia (HP:0000027)2.21397300
90Irregular epiphyses (HP:0010582)2.20715101
91Type I transferrin isoform profile (HP:0003642)2.17735661
92Hypothermia (HP:0002045)2.17488226
93Hypokinesia (HP:0002375)2.16793651
94Poor head control (HP:0002421)2.14323743
95Aplasia/Hypoplasia of the tongue (HP:0010295)2.11311618
96Bone marrow hypocellularity (HP:0005528)2.10808708
97Septo-optic dysplasia (HP:0100842)2.08885525
98Sensory axonal neuropathy (HP:0003390)2.08470629
99Acute myeloid leukemia (HP:0004808)2.08414532
100Aplasia/Hypoplasia of the fovea (HP:0008060)2.07595312
101Hypoplasia of the fovea (HP:0007750)2.07595312
102Bile duct proliferation (HP:0001408)2.07509991
103Abnormal biliary tract physiology (HP:0012439)2.07509991
104Chronic bronchitis (HP:0004469)2.06453052
105Abnormal lung lobation (HP:0002101)2.03020720
106Chronic hepatic failure (HP:0100626)2.02570085
107Abnormality of urine glucose concentration (HP:0011016)2.02045562
108Glycosuria (HP:0003076)2.02045562
109Abnormality of the fovea (HP:0000493)2.01746418
110Medial flaring of the eyebrow (HP:0010747)2.01434963
111Hypoplastic pelvis (HP:0008839)2.00738625
112Delusions (HP:0000746)1.98992681
113Poor speech (HP:0002465)1.97948023
114Delayed puberty (HP:0000823)1.97373812
115Aplasia/Hypoplasia of the sternum (HP:0006714)1.97192136
116Hypogonadotrophic hypogonadism (HP:0000044)1.97136136
117Renal cortical cysts (HP:0000803)1.97033948
118Decreased central vision (HP:0007663)1.96228259
119Overlapping toe (HP:0001845)1.95362273
120Type II lissencephaly (HP:0007260)1.95184586
121Abnormality of alanine metabolism (HP:0010916)1.94731714
122Hyperalaninemia (HP:0003348)1.94731714
123Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94731714
124Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.94038550
125Abnormal protein N-linked glycosylation (HP:0012347)1.94038550
126Abnormal protein glycosylation (HP:0012346)1.94038550
127Abnormal glycosylation (HP:0012345)1.94038550
128Hypoplasia of the uterus (HP:0000013)1.92351974
129Abnormality of the duodenum (HP:0002246)1.91769728
130Abnormality of the renal medulla (HP:0100957)1.91572149
131Optic nerve hypoplasia (HP:0000609)1.91518652
132Squamous cell carcinoma (HP:0002860)1.91126812
133Primary amenorrhea (HP:0000786)1.90282435
134Hypoplasia of the capital femoral epiphysis (HP:0003090)1.89915866
135Absent radius (HP:0003974)1.89856780
136Clubbing of toes (HP:0100760)1.88766793
137Methylmalonic aciduria (HP:0012120)1.88411425
138Nausea (HP:0002018)1.87817989
139Testicular atrophy (HP:0000029)1.86246166
140Tongue fasciculations (HP:0001308)1.85986100
141Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.85244714
142Cystic hygroma (HP:0000476)1.85221506
143Central scotoma (HP:0000603)1.84886747
144True hermaphroditism (HP:0010459)1.84882979
145Spinal muscular atrophy (HP:0007269)1.84550198
146Horseshoe kidney (HP:0000085)1.84357777
147Aplasia/hypoplasia of the uterus (HP:0008684)1.84334532
148Aplasia/Hypoplasia involving the musculature (HP:0001460)1.84193834
149Entropion (HP:0000621)1.82458418
150Increased intramyocellular lipid droplets (HP:0012240)1.81805010
151Poor coordination (HP:0002370)1.81514451
152Personality changes (HP:0000751)1.81212077
153Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80573626
154Oligodactyly (hands) (HP:0001180)1.80434548
155Bronchiectasis (HP:0002110)1.80387162
156Abnormality of renal resorption (HP:0011038)1.80377220
157Respiratory failure (HP:0002878)1.80319234
158Aplasia involving forearm bones (HP:0009822)1.80198320
159Absent forearm bone (HP:0003953)1.80198320
160Abnormal hair whorl (HP:0010721)1.79966359
161Bony spicule pigmentary retinopathy (HP:0007737)1.79859343
162Slender long bone (HP:0003100)1.78215500
163Posterior subcapsular cataract (HP:0007787)1.77991109
164Anosmia (HP:0000458)1.77761317
165Abnormality of chromosome segregation (HP:0002916)1.77700573
166Abnormality of serum amino acid levels (HP:0003112)1.77234619
167Abnormality of the epiphysis of the femoral head (HP:0010574)1.77141428
168Rhabdomyosarcoma (HP:0002859)1.76473839
169Oligodactyly (HP:0012165)1.76229931
170CNS demyelination (HP:0007305)1.75702381
171Mesangial abnormality (HP:0001966)1.75694228
172Abnormal trabecular bone morphology (HP:0100671)1.75570541
173Cleft eyelid (HP:0000625)1.73862837
174Cerebral edema (HP:0002181)1.73569146
175Exercise intolerance (HP:0003546)1.73250922
176Female pseudohermaphroditism (HP:0010458)1.69758548

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K64.00304265
2PLK43.92733503
3BUB13.83438433
4ZAK3.59158101
5LATS23.22201096
6MST43.20622090
7BMPR23.07392417
8TTK2.86153114
9MOS2.85787026
10CDC72.72327450
11TAOK32.69585736
12STK38L2.64147409
13LATS12.60907714
14TRIM282.55345613
15EIF2AK12.46176955
16ERBB42.41157989
17TLK12.38120401
18ADRBK22.36049155
19BRAF2.32413297
20MAP4K22.29219334
21ACVR1B2.24215524
22NEK22.22974418
23TXK2.21224922
24CDK82.15494875
25INSRR2.14768512
26PLK12.14426670
27WEE12.13248854
28ARAF2.09785878
29WNK41.96354650
30BRSK21.94284372
31CHEK21.81547462
32MAP2K61.80850452
33NME11.79869476
34MUSK1.78912745
35LMTK21.67188292
36GRK11.65725372
37TNIK1.60323038
38VRK11.58533667
39MAP3K91.56327287
40KSR21.51785745
41PLK31.47895405
42SRPK11.47700105
43MELK1.41220066
44NEK11.37865555
45BRSK11.36701667
46STK101.35344975
47AURKB1.35237693
48STK31.33876279
49VRK21.27861753
50CCNB11.27249504
51IKBKB1.24607791
52FRK1.24555376
53RAF11.23740923
54PBK1.22136995
55TGFBR11.21071054
56AURKA1.21069317
57DAPK21.17440069
58DYRK21.15477626
59EEF2K1.14874855
60MAP3K81.13778645
61BCKDK1.12941491
62PRKD31.06935999
63WNK31.03380582
64ADRBK11.03033437
65MAP2K70.99884630
66CASK0.95564185
67EIF2AK30.93656605
68DYRK30.91238053
69MAPKAPK50.89522193
70CSNK1G10.88272405
71MAP3K130.85435353
72MAPKAPK30.84792860
73TAOK10.82772146
74CSNK1G30.81962562
75EPHA40.81029310
76NEK90.80296644
77MAPK150.78234796
78GRK70.78077423
79TIE10.77457712
80CHEK10.77027281
81PTK2B0.76993935
82CDK90.76361756
83CDK40.75802504
84MKNK10.74644702
85BMPR1B0.72346594
86CAMKK20.71220437
87MET0.71117961
88PDK20.71017809
89PINK10.70839139
90CDK30.70721003
91MAP3K40.70607627
92TESK20.70320111
93MAPK130.68120440
94STK240.67443284
95STK390.67355919
96TESK10.67179194
97CDK70.66448748
98ATR0.65160178
99RPS6KA40.64291265
100LIMK10.63128165
101CSNK1G20.63079239
102NUAK10.61934221
103MKNK20.61287255
104PIM10.59213319
105PKN10.58206298
106ABL20.57851430
107CHUK0.56835054
108STK380.56358667
109PIM20.55873337
110PRKG20.55763413
111NME20.53186048
112ATM0.52801055
113ITK0.52370025
114NLK0.50766388
115MAP2K10.49702437
116MAP3K110.49124389
117MST1R0.48675998
118PRKAA10.48100901
119IRAK30.46301495
120CDK20.45134193
121DAPK10.43619239
122CDK10.43014247
123RPS6KA50.41067745
124PRKACB0.40503417
125CSNK2A20.39799267
126CAMK2A0.39525137
127MAP3K120.38566052
128ERBB30.37749390
129CSNK1A10.37588934
130AKT30.36894871
131PDK40.35480623
132PDK30.35480623
133PRKACA0.33270655
134PRKCE0.30899520
135AKT20.30081556
136PRKCI0.29942634
137EPHA20.29938396
138PHKG20.29705809
139PHKG10.29705809
140PAK10.29385465
141KIT0.29196853
142MAP3K50.28829683
143MARK30.28289039
144CSNK2A10.26515472
145STK40.26371262
146TSSK60.24838038
147KSR10.24635723
148RPS6KB20.23448921
149EIF2AK20.21053195
150PLK20.18090237
151MAPK110.17365767
152CSNK1A1L0.16692513
153SGK20.15960198
154STK160.14179295
155PASK0.14075480
156ABL10.11366825
157FLT30.10796673

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002325.04638932
2RNA polymerase_Homo sapiens_hsa030204.65056138
3Vitamin B6 metabolism_Homo sapiens_hsa007504.12636449
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.99175935
5Basal transcription factors_Homo sapiens_hsa030223.92502182
6Cell cycle_Homo sapiens_hsa041103.75251773
7RNA transport_Homo sapiens_hsa030133.37277212
8Homologous recombination_Homo sapiens_hsa034403.36850690
9Oxidative phosphorylation_Homo sapiens_hsa001903.28871065
10DNA replication_Homo sapiens_hsa030303.22116451
11RNA degradation_Homo sapiens_hsa030182.99400550
12Base excision repair_Homo sapiens_hsa034102.78240443
13Mismatch repair_Homo sapiens_hsa034302.72592002
14Fanconi anemia pathway_Homo sapiens_hsa034602.60963123
15Pyrimidine metabolism_Homo sapiens_hsa002402.53572442
16Parkinsons disease_Homo sapiens_hsa050122.43273228
17Proteasome_Homo sapiens_hsa030502.42084743
18Nucleotide excision repair_Homo sapiens_hsa034202.40526949
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24973745
20Oocyte meiosis_Homo sapiens_hsa041142.22439713
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.16251453
22Spliceosome_Homo sapiens_hsa030402.02760763
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.96481973
24Non-homologous end-joining_Homo sapiens_hsa034501.95630899
25p53 signaling pathway_Homo sapiens_hsa041151.85053115
26Purine metabolism_Homo sapiens_hsa002301.83245364
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.80635682
28Ovarian steroidogenesis_Homo sapiens_hsa049131.76874000
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.68746851
30mRNA surveillance pathway_Homo sapiens_hsa030151.57973441
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.50332726
32Regulation of autophagy_Homo sapiens_hsa041401.48042193
33Linoleic acid metabolism_Homo sapiens_hsa005911.44858367
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.41938557
35Alzheimers disease_Homo sapiens_hsa050101.41289240
36Circadian rhythm_Homo sapiens_hsa047101.38669559
37Butanoate metabolism_Homo sapiens_hsa006501.36845020
38Propanoate metabolism_Homo sapiens_hsa006401.35712801
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.33762492
40Fatty acid elongation_Homo sapiens_hsa000621.31078400
41Folate biosynthesis_Homo sapiens_hsa007901.28949501
42Phototransduction_Homo sapiens_hsa047441.23598389
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.16636931
44Cardiac muscle contraction_Homo sapiens_hsa042601.09316107
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07256332
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.07198041
47Sulfur metabolism_Homo sapiens_hsa009201.06290339
48Glycerophospholipid metabolism_Homo sapiens_hsa005640.99405870
49Tryptophan metabolism_Homo sapiens_hsa003800.96780854
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95094745
51Epstein-Barr virus infection_Homo sapiens_hsa051690.94536767
52Thyroid cancer_Homo sapiens_hsa052160.94510123
53Other glycan degradation_Homo sapiens_hsa005110.91646229
54One carbon pool by folate_Homo sapiens_hsa006700.90841997
55Collecting duct acid secretion_Homo sapiens_hsa049660.89495185
56Pentose phosphate pathway_Homo sapiens_hsa000300.86797237
57Ether lipid metabolism_Homo sapiens_hsa005650.86779067
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83677479
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82354090
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81588258
61Chemical carcinogenesis_Homo sapiens_hsa052040.74542023
62Pancreatic cancer_Homo sapiens_hsa052120.71932153
63Protein export_Homo sapiens_hsa030600.70950058
64GnRH signaling pathway_Homo sapiens_hsa049120.67117900
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66534225
66Arachidonic acid metabolism_Homo sapiens_hsa005900.64596514
67Steroid biosynthesis_Homo sapiens_hsa001000.64511188
68Peroxisome_Homo sapiens_hsa041460.60229188
69Ribosome_Homo sapiens_hsa030100.59960969
70Prolactin signaling pathway_Homo sapiens_hsa049170.54931455
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54858865
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.54561560
73Pyruvate metabolism_Homo sapiens_hsa006200.54521824
74Sulfur relay system_Homo sapiens_hsa041220.54105095
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.53533237
76Retinol metabolism_Homo sapiens_hsa008300.52524208
77Biosynthesis of amino acids_Homo sapiens_hsa012300.52367309
78Olfactory transduction_Homo sapiens_hsa047400.52130859
79Lysosome_Homo sapiens_hsa041420.51885149
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51289660
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50616232
82Colorectal cancer_Homo sapiens_hsa052100.48668560
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48351782
84HTLV-I infection_Homo sapiens_hsa051660.47685103
85Herpes simplex infection_Homo sapiens_hsa051680.47624384
86TGF-beta signaling pathway_Homo sapiens_hsa043500.47279684
87Nitrogen metabolism_Homo sapiens_hsa009100.46452477
88Rheumatoid arthritis_Homo sapiens_hsa053230.45722690
89Dorso-ventral axis formation_Homo sapiens_hsa043200.45250502
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42459160
91Sphingolipid metabolism_Homo sapiens_hsa006000.42322586
92FoxO signaling pathway_Homo sapiens_hsa040680.40768955
93ABC transporters_Homo sapiens_hsa020100.40370877
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.40170123
95MicroRNAs in cancer_Homo sapiens_hsa052060.38439044
96Huntingtons disease_Homo sapiens_hsa050160.37404707
97mTOR signaling pathway_Homo sapiens_hsa041500.37304645
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36887637
99Viral carcinogenesis_Homo sapiens_hsa052030.36571580
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35980311
101Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35932339
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35841842
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33759091
104Graft-versus-host disease_Homo sapiens_hsa053320.32125460
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31517469
106Shigellosis_Homo sapiens_hsa051310.30827802
107Antigen processing and presentation_Homo sapiens_hsa046120.30249265
108Metabolic pathways_Homo sapiens_hsa011000.29030318
109Arginine and proline metabolism_Homo sapiens_hsa003300.26435512
110Mineral absorption_Homo sapiens_hsa049780.25535859
111beta-Alanine metabolism_Homo sapiens_hsa004100.24749239
112Selenocompound metabolism_Homo sapiens_hsa004500.24461009
113Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.23638816
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23576102
115Galactose metabolism_Homo sapiens_hsa000520.22446891
116Hepatitis B_Homo sapiens_hsa051610.19821990
117Systemic lupus erythematosus_Homo sapiens_hsa053220.19032324
118Tyrosine metabolism_Homo sapiens_hsa003500.19030756
119Glycerolipid metabolism_Homo sapiens_hsa005610.18066938
120Glutathione metabolism_Homo sapiens_hsa004800.17140667
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.17096275
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16958836
123Vibrio cholerae infection_Homo sapiens_hsa051100.16438665
124Apoptosis_Homo sapiens_hsa042100.15472762
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.14677906
126Choline metabolism in cancer_Homo sapiens_hsa052310.14111857
127Primary immunodeficiency_Homo sapiens_hsa053400.13384966
128Bladder cancer_Homo sapiens_hsa052190.12788234
129Vitamin digestion and absorption_Homo sapiens_hsa049770.10945595
130Fructose and mannose metabolism_Homo sapiens_hsa000510.10708080
131VEGF signaling pathway_Homo sapiens_hsa043700.09318132
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.08231012
133Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.07419851
134Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.07394730
135Non-small cell lung cancer_Homo sapiens_hsa052230.06393496
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.05899608
137Inositol phosphate metabolism_Homo sapiens_hsa005620.05580224
138Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.05535686
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.05272784
140Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.05213767
141Glycosaminoglycan degradation_Homo sapiens_hsa005310.04318987
142Intestinal immune network for IgA production_Homo sapiens_hsa046720.03859546
143N-Glycan biosynthesis_Homo sapiens_hsa005100.02341772
144Endometrial cancer_Homo sapiens_hsa052130.01258205
145Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.01150499
146Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.01126823
147SNARE interactions in vesicular transport_Homo sapiens_hsa041300.00891574
148Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040-0.0058103

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