PCGF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)8.83226976
2doxorubicin metabolic process (GO:0044598)8.83226976
3daunorubicin metabolic process (GO:0044597)8.83226976
4regulation of nuclear cell cycle DNA replication (GO:0033262)6.10964704
5histone H4-K12 acetylation (GO:0043983)5.92552910
6regulation of telomere maintenance via telomerase (GO:0032210)5.86956551
7somite rostral/caudal axis specification (GO:0032525)5.79414852
8regulation of mammary gland epithelial cell proliferation (GO:0033599)5.76276269
9aminoglycoside antibiotic metabolic process (GO:0030647)5.64504890
10negative regulation of epidermis development (GO:0045683)5.53635146
11protein localization to kinetochore (GO:0034501)5.48248414
12histone H4-K5 acetylation (GO:0043981)5.45963124
13histone H4-K8 acetylation (GO:0043982)5.45963124
14maintenance of protein location in nucleus (GO:0051457)5.36003739
15negative regulation of telomerase activity (GO:0051974)5.28271099
16negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.28011639
17negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.01542898
18notochord development (GO:0030903)4.88963465
19mitotic sister chromatid segregation (GO:0000070)4.85963123
20negative regulation of cell cycle G2/M phase transition (GO:1902750)4.75429186
21regulation of response to osmotic stress (GO:0047484)4.66272341
22muscle organ morphogenesis (GO:0048644)4.63016517
23heterochromatin organization (GO:0070828)4.61968523
24rRNA transcription (GO:0009303)4.49988406
25positive regulation of DNA-dependent DNA replication (GO:2000105)4.36286439
26regulation of MHC class I biosynthetic process (GO:0045343)4.36046622
27primitive streak formation (GO:0090009)4.27652046
28negative regulation of epidermal cell differentiation (GO:0045605)4.24998752
29negative regulation of telomere maintenance (GO:0032205)4.22855348
30sister chromatid segregation (GO:0000819)4.14705358
31pre-miRNA processing (GO:0031054)4.09882475
32planar cell polarity pathway involved in neural tube closure (GO:0090179)4.06498120
33cell fate commitment involved in formation of primary germ layer (GO:0060795)4.03003233
34protein localization to chromosome, centromeric region (GO:0071459)4.02851475
35branching involved in mammary gland duct morphogenesis (GO:0060444)4.02708395
36nuclear pore complex assembly (GO:0051292)4.01989943
37DNA replication-dependent nucleosome organization (GO:0034723)4.01528553
38DNA replication-dependent nucleosome assembly (GO:0006335)4.01528553
39histone H4-K16 acetylation (GO:0043984)4.00150584
40regulation of apoptotic process involved in morphogenesis (GO:1902337)3.94734630
41DNA replication checkpoint (GO:0000076)3.94494851
42regulation of posttranscriptional gene silencing (GO:0060147)3.89695648
43regulation of gene silencing by miRNA (GO:0060964)3.89695648
44regulation of gene silencing by RNA (GO:0060966)3.89695648
45rRNA methylation (GO:0031167)3.89670079
46regulation of cilium movement (GO:0003352)3.85655740
47rRNA modification (GO:0000154)3.75738383
48regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.73201280
49regulation of telomere maintenance (GO:0032204)3.70670283
50nuclear pore organization (GO:0006999)3.64934351
51chromatin assembly (GO:0031497)3.64912348
52regulation of translation in response to stress (GO:0043555)3.63843172
53nucleoside transmembrane transport (GO:1901642)3.50082249
54bone trabecula formation (GO:0060346)3.48920520
55trophectodermal cell differentiation (GO:0001829)3.44984539
56transcription from mitochondrial promoter (GO:0006390)3.44436145
57regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.42552819
58convergent extension (GO:0060026)3.41465680
59cullin deneddylation (GO:0010388)3.40290089
60cardiovascular system development (GO:0072358)3.39924818
61DNA damage response, detection of DNA damage (GO:0042769)3.39057090
62intestinal epithelial cell development (GO:0060576)3.36558115
63phenol-containing compound catabolic process (GO:0019336)3.36272102
64ribosome biogenesis (GO:0042254)3.30750378
65intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.26941578
66interferon-gamma production (GO:0032609)3.23583967
67cytidine deamination (GO:0009972)3.23076336
68cytidine metabolic process (GO:0046087)3.23076336
69cytidine catabolic process (GO:0006216)3.23076336
70RNA stabilization (GO:0043489)3.22948505
71mRNA stabilization (GO:0048255)3.22948505
72cell migration in hindbrain (GO:0021535)3.18705248
73regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.18576892
74histone arginine methylation (GO:0034969)3.18168937
75intracellular estrogen receptor signaling pathway (GO:0030520)3.18118706
76regulation of telomerase activity (GO:0051972)3.17916212
77regulation of hippo signaling (GO:0035330)3.15595009
78paraxial mesoderm development (GO:0048339)3.13148236
79DNA duplex unwinding (GO:0032508)3.12717438
80regulation of double-strand break repair (GO:2000779)3.12214430
81formation of translation preinitiation complex (GO:0001731)3.10435597
82anterior/posterior axis specification (GO:0009948)3.10347320
83DNA geometric change (GO:0032392)3.10040373
84cochlea morphogenesis (GO:0090103)3.08574914
85retinoic acid receptor signaling pathway (GO:0048384)3.07100328
86axon extension involved in axon guidance (GO:0048846)3.06803879
87neuron projection extension involved in neuron projection guidance (GO:1902284)3.06803879
88maintenance of protein localization in organelle (GO:0072595)3.04994108
89body morphogenesis (GO:0010171)3.04564416
90cell migration involved in gastrulation (GO:0042074)3.04033064
91cell-cell junction maintenance (GO:0045217)3.02955248
92negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.00927115
93pore complex assembly (GO:0046931)3.00498401
94Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.97982039
95quinone metabolic process (GO:1901661)2.95977672
96protein deneddylation (GO:0000338)2.93297738
97regulation of DNA-dependent DNA replication (GO:0090329)2.93014125
98response to dietary excess (GO:0002021)2.92359398
99camera-type eye morphogenesis (GO:0048593)2.91608128
100hormone catabolic process (GO:0042447)2.91010776
101lung epithelium development (GO:0060428)2.90240302
102embryonic axis specification (GO:0000578)2.90020747
103lens fiber cell development (GO:0070307)2.89451816
104neuron recognition (GO:0008038)2.87584885
105intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.87384848
106GDP-mannose metabolic process (GO:0019673)2.87061908
107signal transduction involved in regulation of gene expression (GO:0023019)2.86628728
108protein polyglutamylation (GO:0018095)2.84466250
109spinal cord development (GO:0021510)2.83701434
110DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.83657848
111histone H3-K4 methylation (GO:0051568)2.82905005
112regulation of establishment of planar polarity (GO:0090175)2.82432488
113axonal fasciculation (GO:0007413)2.82337494
114mitochondrion distribution (GO:0048311)2.77083425
115spindle assembly (GO:0051225)2.76673515
116receptor recycling (GO:0001881)2.76657388
117pattern specification involved in kidney development (GO:0061004)2.76618138
118viral transcription (GO:0019083)2.76373119
119G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.75320842
120pseudouridine synthesis (GO:0001522)2.74664105
121non-canonical Wnt signaling pathway (GO:0035567)2.73475877
122axon extension (GO:0048675)2.70904289
123semaphorin-plexin signaling pathway (GO:0071526)2.68524071
124establishment of planar polarity (GO:0001736)2.66101671
125establishment of tissue polarity (GO:0007164)2.66101671
126translational termination (GO:0006415)2.65377722
127negative regulation of catenin import into nucleus (GO:0035414)2.63805459
128branching involved in salivary gland morphogenesis (GO:0060445)2.61847046
129postsynaptic membrane organization (GO:0001941)2.59673702
130embryonic body morphogenesis (GO:0010172)2.56592595
131RNA localization (GO:0006403)2.54392469
132negative regulation of axon extension involved in axon guidance (GO:0048843)2.48317059
133ribosomal small subunit biogenesis (GO:0042274)2.47989370
134regulation of axon extension involved in axon guidance (GO:0048841)2.47301172
135negative regulation of axon guidance (GO:1902668)2.46948068
136regulation of axon guidance (GO:1902667)2.46534870
137establishment or maintenance of monopolar cell polarity (GO:0061339)2.43917217
138establishment of monopolar cell polarity (GO:0061162)2.43917217
139establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.39042074
140cell junction maintenance (GO:0034331)2.36420653
141neural tube development (GO:0021915)2.33020165
142neuronal stem cell maintenance (GO:0097150)2.32263721
143positive regulation of synapse assembly (GO:0051965)2.30560969
144pyrimidine nucleobase catabolic process (GO:0006208)2.29793001
145embryonic retina morphogenesis in camera-type eye (GO:0060059)2.28775669
146presynaptic membrane assembly (GO:0097105)2.27555276
147regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.27517413
148cell proliferation in forebrain (GO:0021846)2.27403208
149dendritic spine morphogenesis (GO:0060997)2.26850069
150renal system development (GO:0072001)2.25761734
151establishment of apical/basal cell polarity (GO:0035089)2.25731538
152lateral sprouting from an epithelium (GO:0060601)2.24715419
153neuron projection extension (GO:1990138)2.23588281
154protein retention in ER lumen (GO:0006621)2.23235677
155cranial nerve morphogenesis (GO:0021602)2.22302954
156apical protein localization (GO:0045176)2.22093847
157lung-associated mesenchyme development (GO:0060484)2.21856420
158nephron epithelium morphogenesis (GO:0072088)2.21616006
159nephron tubule morphogenesis (GO:0072078)2.21616006
160presynaptic membrane organization (GO:0097090)2.20083519
161generation of neurons (GO:0048699)2.19517794
162skeletal muscle organ development (GO:0060538)2.19486763
163nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.19414198
164cell-cell signaling involved in cell fate commitment (GO:0045168)2.18351617
165positive regulation of smoothened signaling pathway (GO:0045880)2.18253904
166neuron cell-cell adhesion (GO:0007158)2.16935637
167endothelial cell chemotaxis (GO:0035767)2.16268258
168asymmetric protein localization (GO:0008105)2.14861890
169midbrain development (GO:0030901)2.14806474
170kidney mesenchyme development (GO:0072074)2.12524477
171basement membrane organization (GO:0071711)2.11228210
172cellular protein complex disassembly (GO:0043624)2.10739472
173outer ear morphogenesis (GO:0042473)2.10734354
174positive regulation of gastrulation (GO:2000543)2.10224150
175adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.09941927
176translational elongation (GO:0006414)2.09659034
177protein complex disassembly (GO:0043241)2.09589635
178SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.09552205
179L-serine metabolic process (GO:0006563)2.09448590
180maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.08993034
181protein localization to synapse (GO:0035418)2.08589315
182cotranslational protein targeting to membrane (GO:0006613)2.08507677
183establishment of mitochondrion localization (GO:0051654)2.07476151
184protein targeting to ER (GO:0045047)2.06762186
185urogenital system development (GO:0001655)2.06467342
186cranial nerve development (GO:0021545)2.06178512
187nucleosome disassembly (GO:0006337)2.05894629
188protein-DNA complex disassembly (GO:0032986)2.05894629
189developmental induction (GO:0031128)2.05311745
190cerebellar Purkinje cell layer development (GO:0021680)2.04694329
191negative regulation of oligodendrocyte differentiation (GO:0048715)2.04682936
192substrate-independent telencephalic tangential migration (GO:0021826)2.04103033
193substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.04103033
194negative regulation of chondrocyte differentiation (GO:0032331)2.03767075
195axon ensheathment in central nervous system (GO:0032291)2.03460921
196central nervous system myelination (GO:0022010)2.03460921

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.24663959
2KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.24663959
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.24663959
4E2F7_22180533_ChIP-Seq_HELA_Human4.67200643
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.50645993
6TP63_19390658_ChIP-ChIP_HaCaT_Human3.60351383
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.40731659
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.27293954
9NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.25550412
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.06299277
11SOX2_18358816_ChIP-ChIP_MESCs_Mouse3.00176749
12SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.91207615
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.76670767
14ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.69478039
15TCF3_18692474_ChIP-Seq_MESCs_Mouse2.58844590
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.57254216
17ERG_21242973_ChIP-ChIP_JURKAT_Human2.52526352
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.52107135
19EZH2_22144423_ChIP-Seq_EOC_Human2.51081310
20TCF3_18692474_ChIP-Seq_MEFs_Mouse2.50885105
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.40830984
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.27188253
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.25848536
24MYC_18555785_ChIP-Seq_MESCs_Mouse2.19237507
25EZH2_18974828_ChIP-Seq_MESCs_Mouse2.15265081
26RNF2_18974828_ChIP-Seq_MESCs_Mouse2.15265081
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.14920190
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04634501
29* NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.03329536
30POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.02449310
31NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.01938551
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.99425575
33TP63_17297297_ChIP-ChIP_HaCaT_Human1.97930481
34ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.97061929
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.96200103
36* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.94699276
37POU5F1_16518401_ChIP-PET_MESCs_Mouse1.87757365
38JARID2_20064375_ChIP-Seq_MESCs_Mouse1.87543526
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.86197551
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.85825498
41SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.85295468
42KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.85255327
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.84193088
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.84082318
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.83933688
46SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.83481116
47NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.81014143
48SOX2_18555785_ChIP-Seq_MESCs_Mouse1.80386804
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75189743
50ZNF263_19887448_ChIP-Seq_K562_Human1.68837395
51TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.67556282
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.67487564
53* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.66750234
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.66683144
55* KDM2B_26808549_Chip-Seq_K562_Human1.66335749
56* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65834945
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.65445496
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63752383
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62424504
60* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.58409580
61IRF1_19129219_ChIP-ChIP_H3396_Human1.57482839
62* CTCF_27219007_Chip-Seq_Bcells_Human1.57387154
63* RING1B_27294783_Chip-Seq_ESCs_Mouse1.54164634
64* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.53055083
65* LXR_22292898_ChIP-Seq_THP-1_Human1.52154435
66EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.51878721
67OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.51362618
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.51046365
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.50575889
70SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.49105017
71TRIM28_21343339_ChIP-Seq_HEK293_Human1.48866859
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48649110
73SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.48631994
74MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.46548447
75NANOG_18692474_ChIP-Seq_MESCs_Mouse1.45379061
76PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.45017320
77SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42647024
78* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.42076668
79* RACK7_27058665_Chip-Seq_MCF-7_Human1.41709569
80* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40583560
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39702641
82HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39657664
83NANOG_18692474_ChIP-Seq_MEFs_Mouse1.38645182
84* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38404399
85* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36238839
86SOX2_18692474_ChIP-Seq_MESCs_Mouse1.35596007
87SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.34406026
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32606766
89* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30430376
90* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29815926
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29041957
92SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.28598986
93MYC_22102868_ChIP-Seq_BL_Human1.27897099
94NANOG_21062744_ChIP-ChIP_HESCs_Human1.27156207
95* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27120705
96EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.25533725
97* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.25040677
98SOX2_18692474_ChIP-Seq_MEFs_Mouse1.24877530
99TET1_21451524_ChIP-Seq_MESCs_Mouse1.23993780
100KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.22962262
101ESR2_21235772_ChIP-Seq_MCF-7_Human1.22669365
102MTF2_20144788_ChIP-Seq_MESCs_Mouse1.22656702
103TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19857556
104DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19560563
105NANOG_16518401_ChIP-PET_MESCs_Mouse1.19553678
106* E2F1_17053090_ChIP-ChIP_MCF-7_Human1.19412769
107DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18070109
108NANOG_16153702_ChIP-ChIP_HESCs_Human1.14711725
109POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.13701526
110ISL1_27105846_Chip-Seq_CPCs_Mouse1.13655454
111CREB1_26743006_Chip-Seq_LNCaP_Human1.12146575
112POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10858152
113CDX2_20551321_ChIP-Seq_CACO-2_Human1.10722622
114* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10165285
115MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.10018090
116EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07097010
117TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06836486
118SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05810424
119MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05498140
120* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04681012
121PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03803784
122STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.02787190
123* SOX3_22085726_ChIP-Seq_NPCs_Mouse1.02221096
124SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01679613
125ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01585621
126NOTCH1_21737748_ChIP-Seq_TLL_Human1.00632270
127NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00150774
128ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99124682
129KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.97046403
130TP53_22127205_ChIP-Seq_IMR90_Human0.95863935
131* FOXP1_21924763_ChIP-Seq_HESCs_Human0.95657566
132ELK3_25401928_ChIP-Seq_HUVEC_Human0.94862439
133REST_21632747_ChIP-Seq_MESCs_Mouse0.94542762
134* SMC4_20622854_ChIP-Seq_HELA_Human0.94219300
135XRN2_22483619_ChIP-Seq_HELA_Human0.94209079
136ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94007380
137ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93974700
138SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93860084
139* RARB_27405468_Chip-Seq_BRAIN_Mouse0.93004554
140* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92805182
141P68_20966046_ChIP-Seq_HELA_Human0.92683788
142SOX2_16153702_ChIP-ChIP_HESCs_Human0.92671907
143* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92096434
144STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92073157
145REST_18959480_ChIP-ChIP_MESCs_Mouse0.91121959
146* RNF2_27304074_Chip-Seq_NSC_Mouse0.90987763
147RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89836738
148CREB1_15753290_ChIP-ChIP_HEK293T_Human0.89477818
149TBX3_20139965_ChIP-Seq_ESCs_Mouse0.88128170
150EST1_17652178_ChIP-ChIP_JURKAT_Human0.87918340
151TP53_20018659_ChIP-ChIP_R1E_Mouse0.87348668
152TBX3_20139965_ChIP-Seq_MESCs_Mouse0.86659337
153KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86421760
154KAP1_27257070_Chip-Seq_ESCs_Mouse0.86210234
155HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86172503
156SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.82915825
157TTF2_22483619_ChIP-Seq_HELA_Human0.82751335
158NCOR1_26117541_ChIP-Seq_K562_Human0.81864685
159RING1B_27294783_Chip-Seq_NPCs_Mouse0.81658465
160MYCN_18555785_ChIP-Seq_MESCs_Mouse0.80897910
161SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.79806825
162NELFA_20434984_ChIP-Seq_ESCs_Mouse0.79746101
163YY1_22570637_ChIP-Seq_MALME-3M_Human0.76532447
164SALL1_21062744_ChIP-ChIP_HESCs_Human0.75470862
165KDM5A_27292631_Chip-Seq_BREAST_Human0.74417865
166CIITA_25753668_ChIP-Seq_RAJI_Human0.74316889
167* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.74080800
168RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.74023686
169* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.73223909
170* TCF7_22412390_ChIP-Seq_EML_Mouse0.72688498
171STAT3_18555785_ChIP-Seq_MESCs_Mouse0.71871028
172FOXP3_21729870_ChIP-Seq_TREG_Human0.71829415

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.31695165
2MP0003890_abnormal_embryonic-extraembry3.63004142
3MP0004264_abnormal_extraembryonic_tissu3.62319186
4MP0008057_abnormal_DNA_replication3.25028035
5MP0003122_maternal_imprinting3.09889757
6MP0002254_reproductive_system_inflammat3.06397742
7MP0005394_taste/olfaction_phenotype3.04520654
8MP0005499_abnormal_olfactory_system3.04520654
9MP0003011_delayed_dark_adaptation2.87017195
10MP0010030_abnormal_orbit_morphology2.86208593
11MP0002653_abnormal_ependyma_morphology2.85514077
12MP0004957_abnormal_blastocyst_morpholog2.69422460
13MP0000566_synostosis2.68486631
14MP0003136_yellow_coat_color2.53222450
15MP0003121_genomic_imprinting2.48493421
16MP0004858_abnormal_nervous_system2.43627066
17MP0005075_abnormal_melanosome_morpholog2.39632237
18MP0000678_abnormal_parathyroid_gland2.38223630
19MP0005257_abnormal_intraocular_pressure2.18677188
20MP0000778_abnormal_nervous_system2.02272997
21MP0009379_abnormal_foot_pigmentation1.96468535
22MP0000049_abnormal_middle_ear1.92726136
23MP0010352_gastrointestinal_tract_polyps1.92687138
24MP0001293_anophthalmia1.91151922
25MP0003123_paternal_imprinting1.89881391
26MP0003705_abnormal_hypodermis_morpholog1.88893052
27MP0005380_embryogenesis_phenotype1.84874101
28MP0001672_abnormal_embryogenesis/_devel1.84874101
29MP0003938_abnormal_ear_development1.81430026
30MP0003119_abnormal_digestive_system1.76503038
31MP0004133_heterotaxia1.76016812
32MP0002332_abnormal_exercise_endurance1.74161220
33MP0003283_abnormal_digestive_organ1.73126841
34MP0000537_abnormal_urethra_morphology1.72169592
35MP0008789_abnormal_olfactory_epithelium1.68629178
36MP0002932_abnormal_joint_morphology1.66910113
37MP0002088_abnormal_embryonic_growth/wei1.66342652
38MP0003984_embryonic_growth_retardation1.65152328
39MP0003077_abnormal_cell_cycle1.65138426
40MP0003111_abnormal_nucleus_morphology1.64871880
41MP0009053_abnormal_anal_canal1.61460053
42MP0002085_abnormal_embryonic_tissue1.59533556
43MP0002277_abnormal_respiratory_mucosa1.56510780
44MP0005503_abnormal_tendon_morphology1.56353326
45MP0000762_abnormal_tongue_morphology1.52806737
46MP0000350_abnormal_cell_proliferation1.51888153
47MP0002249_abnormal_larynx_morphology1.50617732
48MP0002084_abnormal_developmental_patter1.46317448
49MP0003755_abnormal_palate_morphology1.40467606
50MP0001299_abnormal_eye_distance/1.40342602
51MP0001849_ear_inflammation1.39676369
52MP0010094_abnormal_chromosome_stability1.39507810
53MP0004859_abnormal_synaptic_plasticity1.39217275
54MP0002092_abnormal_eye_morphology1.39063785
55MP0008961_abnormal_basal_metabolism1.38863703
56MP0002127_abnormal_cardiovascular_syste1.38667321
57MP0005248_abnormal_Harderian_gland1.38533739
58MP0002086_abnormal_extraembryonic_tissu1.37728975
59MP0002089_abnormal_postnatal_growth/wei1.37458586
60MP0009384_cardiac_valve_regurgitation1.36130041
61MP0002233_abnormal_nose_morphology1.32714627
62MP0000428_abnormal_craniofacial_morphol1.32294446
63MP0003935_abnormal_craniofacial_develop1.32128612
64MP0005423_abnormal_somatic_nervous1.30163755
65MP0004197_abnormal_fetal_growth/weight/1.29991705
66MP0000432_abnormal_head_morphology1.26367090
67MP0000955_abnormal_spinal_cord1.26123880
68MP0006035_abnormal_mitochondrial_morpho1.25738465
69MP0008932_abnormal_embryonic_tissue1.25166273
70MP0002184_abnormal_innervation1.23693099
71MP0003315_abnormal_perineum_morphology1.23220085
72* MP0002114_abnormal_axial_skeleton1.19510804
73MP0008438_abnormal_cutaneous_collagen1.14296917
74MP0003937_abnormal_limbs/digits/tail_de1.12935056
75MP0001346_abnormal_lacrimal_gland1.12684520
76MP0003880_abnormal_central_pattern1.12404337
77MP0002751_abnormal_autonomic_nervous1.11490888
78MP0003787_abnormal_imprinting1.10026099
79MP0008007_abnormal_cellular_replicative1.09649498
80MP0003693_abnormal_embryo_hatching1.08960370
81MP0001697_abnormal_embryo_size1.08485724
82MP0001188_hyperpigmentation1.08317160
83* MP0002116_abnormal_craniofacial_bone1.08086238
84MP0003115_abnormal_respiratory_system1.05766690
85MP0005409_darkened_coat_color1.05519739
86MP0001286_abnormal_eye_development1.05193174
87MP0000026_abnormal_inner_ear1.03670842
88MP0005377_hearing/vestibular/ear_phenot1.02679953
89MP0003878_abnormal_ear_physiology1.02679953
90MP0002152_abnormal_brain_morphology1.02571820
91MP0000579_abnormal_nail_morphology1.02534839
92MP0003942_abnormal_urinary_system1.02358336
93MP0003941_abnormal_skin_development1.02236610
94MP0001730_embryonic_growth_arrest1.01482644
95MP0004270_analgesia0.98506850
96MP0003861_abnormal_nervous_system0.96458639
97MP0002111_abnormal_tail_morphology0.95095782
98MP0002282_abnormal_trachea_morphology0.94312146
99MP0003137_abnormal_impulse_conducting0.92119693
100MP0005623_abnormal_meninges_morphology0.91738947
101MP0005391_vision/eye_phenotype0.91531761
102MP0002080_prenatal_lethality0.91209266
103MP0002925_abnormal_cardiovascular_devel0.91149099
104MP0003786_premature_aging0.90751477
105MP0001502_abnormal_circadian_rhythm0.90139544
106MP0000313_abnormal_cell_death0.89287939
107MP0001348_abnormal_lacrimal_gland0.89242845
108MP0002938_white_spotting0.89134013
109MP0002234_abnormal_pharynx_morphology0.89102583
110MP0004885_abnormal_endolymph0.88607759
111MP0000490_abnormal_crypts_of0.88536613
112MP0002752_abnormal_somatic_nervous0.88033068
113MP0003635_abnormal_synaptic_transmissio0.87882624
114MP0005171_absent_coat_pigmentation0.87169855
115MP0002396_abnormal_hematopoietic_system0.87131525
116MP0008058_abnormal_DNA_repair0.85280061
117MP0009703_decreased_birth_body0.84997864
118MP0002557_abnormal_social/conspecific_i0.83994927
119MP0001529_abnormal_vocalization0.83618701
120MP0002882_abnormal_neuron_morphology0.83229612
121MP0008770_decreased_survivor_rate0.82218774
122MP0002063_abnormal_learning/memory/cond0.80230591
123MP0000462_abnormal_digestive_system0.79633090
124MP0002697_abnormal_eye_size0.79141842
125MP0002108_abnormal_muscle_morphology0.79132898
126MP0009672_abnormal_birth_weight0.78710268
127* MP0005508_abnormal_skeleton_morphology0.78272041
128* MP0002081_perinatal_lethality0.78199794
129MP0005266_abnormal_metabolism0.77986306
130MP0002822_catalepsy0.77197486
131MP0001270_distended_abdomen0.76879312
132MP0003385_abnormal_body_wall0.76790697
133MP0001340_abnormal_eyelid_morphology0.75178020
134MP0002734_abnormal_mechanical_nocicepti0.75003687
135MP0005076_abnormal_cell_differentiation0.74222857
136MP0003567_abnormal_fetal_cardiomyocyte0.74114187
137MP0002098_abnormal_vibrissa_morphology0.74037788
138MP0002132_abnormal_respiratory_system0.72252802
139MP0009250_abnormal_appendicular_skeleto0.69725609
140MP0002970_abnormal_white_adipose0.68269951
141MP0002109_abnormal_limb_morphology0.66873796
142MP0005367_renal/urinary_system_phenotyp0.66444465
143MP0000516_abnormal_urinary_system0.66444465
144MP0000631_abnormal_neuroendocrine_gland0.65604517
145MP0000534_abnormal_ureter_morphology0.64204339
146MP0004272_abnormal_basement_membrane0.64027035

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.57332661
2Hepatoblastoma (HP:0002884)5.01454712
3Rib fusion (HP:0000902)4.91729852
4Hypochromic microcytic anemia (HP:0004840)4.83826400
5Ependymoma (HP:0002888)4.27196953
6Abnormality of the lower motor neuron (HP:0002366)4.13432572
7Multiple enchondromatosis (HP:0005701)3.92003636
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.91317367
9Nephroblastoma (Wilms tumor) (HP:0002667)3.66974957
10Neoplasm of striated muscle (HP:0009728)3.54458676
11Embryonal renal neoplasm (HP:0011794)3.41895395
12Chromsome breakage (HP:0040012)3.39318437
13Abnormality of the astrocytes (HP:0100707)3.30257295
14Astrocytoma (HP:0009592)3.30257295
15Rectal fistula (HP:0100590)3.29101825
16Rectovaginal fistula (HP:0000143)3.29101825
17Rhabdomyosarcoma (HP:0002859)3.27530061
18Aplasia/hypoplasia of the humerus (HP:0006507)3.05174307
19Intestinal fistula (HP:0100819)3.02966415
20Bifid tongue (HP:0010297)2.99292105
21Fused cervical vertebrae (HP:0002949)2.99059982
22Short humerus (HP:0005792)2.95457255
23Shawl scrotum (HP:0000049)2.90648673
24Hypoplasia of the fovea (HP:0007750)2.83796852
25Aplasia/Hypoplasia of the fovea (HP:0008060)2.83796852
26Shallow orbits (HP:0000586)2.81585846
27Partial duplication of thumb phalanx (HP:0009944)2.81300609
28Abnormal lung lobation (HP:0002101)2.78802293
29Vaginal fistula (HP:0004320)2.76817257
30Renal duplication (HP:0000075)2.76561423
31Septo-optic dysplasia (HP:0100842)2.73245254
32Meckel diverticulum (HP:0002245)2.72710276
33Supernumerary spleens (HP:0009799)2.69681096
34Abnormality of the ileum (HP:0001549)2.68011732
35Glioma (HP:0009733)2.67601355
36Trismus (HP:0000211)2.64080621
37Turricephaly (HP:0000262)2.63544285
38Partial duplication of the phalanx of hand (HP:0009999)2.60620421
39Protrusio acetabuli (HP:0003179)2.59542779
40Testicular atrophy (HP:0000029)2.59358002
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.58098732
42Coronal craniosynostosis (HP:0004440)2.56935807
43Abnormality of the salivary glands (HP:0010286)2.55517024
44Neonatal short-limb short stature (HP:0008921)2.51151581
45Broad metatarsal (HP:0001783)2.51049584
46Amyotrophic lateral sclerosis (HP:0007354)2.49894004
47Preauricular skin tag (HP:0000384)2.46557674
48Impulsivity (HP:0100710)2.40607413
49Abnormality of the phalanges of the hallux (HP:0010057)2.38808552
50Medulloblastoma (HP:0002885)2.37762668
51Hyperacusis (HP:0010780)2.37631047
52Anomalous pulmonary venous return (HP:0010772)2.34706208
53Preauricular pit (HP:0004467)2.33759508
54Periauricular skin pits (HP:0100277)2.33759508
55Abnormality of chromosome segregation (HP:0002916)2.33437036
56Abnormality of dentin (HP:0010299)2.32147102
57Short 5th finger (HP:0009237)2.30949539
58Aplasia/Hypoplasia of the sternum (HP:0006714)2.30784302
59Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.27193341
60Pendular nystagmus (HP:0012043)2.26961937
61Abnormality of the aortic arch (HP:0012303)2.26328013
62Supernumerary ribs (HP:0005815)2.24270438
63Horizontal nystagmus (HP:0000666)2.23437246
64Abnormality of the pubic bones (HP:0003172)2.22883406
65Vertebral fusion (HP:0002948)2.22375809
66Skin tags (HP:0010609)2.22291801
67Large earlobe (HP:0009748)2.19826672
68Anophthalmia (HP:0000528)2.19044709
69Bronchomalacia (HP:0002780)2.17372369
70Malignant neoplasm of the central nervous system (HP:0100836)2.17139233
71Nasolacrimal duct obstruction (HP:0000579)2.14963415
72Neoplasm of the heart (HP:0100544)2.13766059
73Premature rupture of membranes (HP:0001788)2.10700647
74Abnormality of the distal phalanx of the thumb (HP:0009617)2.10653004
75Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.10627376
76Ragged-red muscle fibers (HP:0003200)2.09531935
77Atresia of the external auditory canal (HP:0000413)2.08553829
78Abnormality of the labia minora (HP:0012880)2.07896836
79Abnormality of the fovea (HP:0000493)2.06722936
80Neoplasm of the oral cavity (HP:0100649)2.06006573
81Duodenal stenosis (HP:0100867)2.05490511
82Small intestinal stenosis (HP:0012848)2.05490511
83Facial cleft (HP:0002006)2.04192102
84Supernumerary bones of the axial skeleton (HP:0009144)2.04164642
85Abnormality of the pulmonary veins (HP:0011718)2.04135437
86Missing ribs (HP:0000921)2.02603375
87Selective tooth agenesis (HP:0001592)2.02170829
88Aplasia involving bones of the upper limbs (HP:0009823)2.00323007
89Aplasia of the phalanges of the hand (HP:0009802)2.00323007
90Aplasia involving bones of the extremities (HP:0009825)2.00323007
91Tongue fasciculations (HP:0001308)1.98894734
92Embryonal neoplasm (HP:0002898)1.98845073
93Morphological abnormality of the middle ear (HP:0008609)1.97658852
94Hypochromic anemia (HP:0001931)1.97537458
95Concave nail (HP:0001598)1.97155072
96Abnormality of the diencephalon (HP:0010662)1.97034954
97Hyperinsulinemic hypoglycemia (HP:0000825)1.96305122
98Generalized hypotonia (HP:0001290)1.95960530
99Pseudobulbar signs (HP:0002200)1.93218254
100Maternal diabetes (HP:0009800)1.92092551
101Skin pits (HP:0100276)1.91272972
102Abnormal number of incisors (HP:0011064)1.90792504
103Bladder diverticulum (HP:0000015)1.88952770
104Absent epiphyses (HP:0010577)1.87754144
105Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.87754144
106Atrophy/Degeneration involving motor neurons (HP:0007373)1.87582563
107Duplication of thumb phalanx (HP:0009942)1.83034964
108Abnormal cartilage morphology (HP:0002763)1.82887846
109Elfin facies (HP:0004428)1.82771525
110Preaxial foot polydactyly (HP:0001841)1.82498416
111Abnormality of the lacrimal duct (HP:0011481)1.81500029
112Abdominal situs inversus (HP:0003363)1.80998615
113Abnormality of abdominal situs (HP:0011620)1.80998615
114Overriding aorta (HP:0002623)1.80748639
115Supernumerary nipples (HP:0002558)1.79711792
116Myokymia (HP:0002411)1.79373696
117Abnormality of the musculature of the hand (HP:0001421)1.79177748
118Progressive muscle weakness (HP:0003323)1.78834307
119High anterior hairline (HP:0009890)1.78797442
120Aplasia/Hypoplasia of the macula (HP:0008059)1.78336100
121Hypoplastic pelvis (HP:0008839)1.77763742
122Ulnar bowing (HP:0003031)1.77596437
123Muscle fibrillation (HP:0010546)1.77544737
124Prominent occiput (HP:0000269)1.76568646
125Neuroectodermal neoplasm (HP:0030061)1.76300100
126Neuroepithelial neoplasm (HP:0030063)1.76300100
127Nervous tissue neoplasm (HP:0030060)1.76300100
128Reticulocytopenia (HP:0001896)1.75693538
129Ectopic anus (HP:0004397)1.75567707
130Progressive external ophthalmoplegia (HP:0000590)1.74486480
131Enlarged penis (HP:0000040)1.73142294
132Hypoventilation (HP:0002791)1.72458818
133Choanal stenosis (HP:0000452)1.71609923
134Patellar aplasia (HP:0006443)1.70861343
135Trigonocephaly (HP:0000243)1.70486142
136Humeroradial synostosis (HP:0003041)1.70242714
137Synostosis involving the elbow (HP:0003938)1.70242714
138Obstructive sleep apnea (HP:0002870)1.65637698
139Aplasia/Hypoplasia of the patella (HP:0006498)1.64090753
140Broad thumb (HP:0011304)1.63656770
141Arnold-Chiari malformation (HP:0002308)1.61876356
142Broad finger (HP:0001500)1.61202319
143Renovascular hypertension (HP:0100817)1.60421013
144Broad palm (HP:0001169)1.60088217
145Broad phalanges of the hand (HP:0009768)1.59897402
146Wide anterior fontanel (HP:0000260)1.58465787
147Midline defect of the nose (HP:0004122)1.58299151
148Vitreoretinal degeneration (HP:0000655)1.58042443
149Hypoplasia of the capital femoral epiphysis (HP:0003090)1.57749652
150Abnormality of cells of the erythroid lineage (HP:0012130)1.57394756
151Increased nuchal translucency (HP:0010880)1.57272601
152Sleep apnea (HP:0010535)1.56702733
153Broad long bones (HP:0005622)1.55967728
154Thin ribs (HP:0000883)1.55869361
155Cutaneous finger syndactyly (HP:0010554)1.55407497
156Insomnia (HP:0100785)1.55055356
157Abnormality of the 4th metacarpal (HP:0010012)1.54695838
158Absent septum pellucidum (HP:0001331)1.54679147
159Oligodactyly (HP:0012165)1.54436305
160Bowel diverticulosis (HP:0005222)1.54316805
161Renal dysplasia (HP:0000110)1.52862619
162Hypoplastic ischia (HP:0003175)1.52346481
163Broad phalanx (HP:0006009)1.51492213
164Myelomeningocele (HP:0002475)1.49963672
165Deviation of the hallux (HP:0010051)1.49841960
166Broad distal phalanx of finger (HP:0009836)1.49665404
167Disproportionate tall stature (HP:0001519)1.48007709
168Cervical subluxation (HP:0003308)1.47746079
169Cutaneous syndactyly (HP:0012725)1.47192779
170Down-sloping shoulders (HP:0200021)1.45235182
171Biconcave vertebral bodies (HP:0004586)1.44535402
172Broad toe (HP:0001837)1.44322268
173Vertebral clefting (HP:0008428)1.43999927
174Esophageal atresia (HP:0002032)1.43420901
175Pterygium (HP:0001059)1.41567544
176Genu recurvatum (HP:0002816)1.41534094
177Hemivertebrae (HP:0002937)1.41476211
178Bowing of the arm (HP:0006488)1.40445265
179Bowed forearm bones (HP:0003956)1.40445265
180Mitral regurgitation (HP:0001653)1.40291127
181Ankle contracture (HP:0006466)1.39797084
182Long palpebral fissure (HP:0000637)1.38344370
183Aplasia/Hypoplasia of the breasts (HP:0010311)1.38254764

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.70097975
2GRK54.41425243
3ERN13.83932016
4GRK63.26866979
5TYRO33.00043892
6ADRBK22.86393169
7TTK2.82767847
8PNCK2.79666130
9TRIB32.66215419
10GRK12.54004792
11EPHA22.25814111
12TNIK2.23422330
13MATK2.19134165
14CSF1R2.18506357
15MAPK72.12819831
16CDK72.06783086
17TGFBR21.99754122
18GRK71.98205347
19CASK1.93303538
20PRKD31.80746145
21MAPK151.78605020
22WNK11.66169831
23STK101.64602768
24FGFR41.61426357
25AKT31.61322197
26CHEK21.53971332
27CAMK1G1.53383580
28FGFR21.53143862
29PAK41.48930022
30MOS1.44397342
31WNK41.44085430
32LATS21.40948796
33CAMK41.39583106
34PLK11.38064909
35NME11.28400532
36VRK21.25531557
37CAMK1D1.24467473
38MAP3K101.22813317
39PKN21.18864345
40ICK1.18320957
41MARK21.15766147
42PRKG21.12059718
43NTRK31.10491302
44HIPK21.10298917
45CDC71.06960538
46EEF2K1.06058427
47DMPK1.05493921
48BRD41.02038305
49DDR21.01110177
50RPS6KA20.99985456
51ADRBK10.96464065
52CHEK10.96083579
53MET0.93776997
54SMG10.91248825
55SIK30.90254069
56PDGFRA0.88852581
57NEK20.85995774
58AKT20.85744693
59NTRK10.84050919
60NEK10.82721874
61ALK0.81835177
62ERBB40.80677859
63SRPK10.80166472
64PRKCI0.79655570
65MTOR0.78918880
66BRSK10.77974796
67MAP2K40.77786189
68LMTK20.77647051
69EPHA40.77486128
70FGFR30.75716389
71RPS6KB20.74371939
72PRKCG0.73347633
73MST1R0.73198943
74DYRK20.72690574
75LIMK10.72213201
76BUB10.71743448
77TAF10.71590655
78FGFR10.70641177
79SGK4940.67867931
80SGK2230.67867931
81CDK20.66784271
82TSSK60.66730108
83MAP2K60.65264107
84DYRK30.64145226
85AURKA0.63353339
86WEE10.62783613
87CDK140.62512041
88EIF2AK20.62498067
89PRPF4B0.61477472
90LATS10.59578580
91PASK0.58168951
92CDK30.57007485
93MINK10.56460298
94RPS6KC10.56088838
95RPS6KL10.56088838
96ATM0.55386312
97LRRK20.54566050
98ILK0.54485559
99PAK20.54361858
100PDGFRB0.53910954
101CSK0.53675940
102TAOK20.53352480
103MAP2K70.53073480
104SIK20.52850266
105TESK10.51874877
106ERBB20.50449308
107PTK20.50079751
108PTK60.49747142
109BRAF0.49467558
110ATR0.48265826
111RPS6KA60.48200710
112MARK10.47810684
113BMX0.47079642
114AURKB0.46560196
115PRKD20.46544147
116CDK10.44285713
117STK380.43967707
118CSNK1E0.43674574
119CDK40.43651953
120PRKCZ0.43119760
121PHKG10.42953246
122PHKG20.42953246
123UHMK10.42866770
124STK38L0.41252370
125CDK50.38499931
126CAMK10.37964527
127NTRK20.37887531
128PRKAA10.37715871
129MAP3K90.36019799
130PAK10.35574928
131EPHB20.34646987
132MAPK140.34364889
133GSK3B0.33938444
134CDK80.32790178
135MAPK100.31860264
136YES10.31556277
137MAPK10.31124226
138DYRK1B0.29837629
139CDC42BPA0.29440456
140MAP3K70.28588845
141SIK10.28540854
142RIPK10.24034185
143AKT10.23722211
144DYRK1A0.23692774
145MAPK120.23225445
146CHUK0.22908147
147CDK180.21585914
148CDK150.19765668
149PRKCD0.19610158
150CDK11A0.19273152
151IGF1R0.15061136
152MAPKAPK30.14190350
153INSR0.13027280

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.80646301
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.16700436
3Vitamin B6 metabolism_Homo sapiens_hsa007503.93274643
4Fructose and mannose metabolism_Homo sapiens_hsa000512.83663629
5RNA transport_Homo sapiens_hsa030132.47943579
6DNA replication_Homo sapiens_hsa030302.44047335
7Mismatch repair_Homo sapiens_hsa034302.40402512
8Fanconi anemia pathway_Homo sapiens_hsa034602.33774194
9mRNA surveillance pathway_Homo sapiens_hsa030152.31999596
10Basal cell carcinoma_Homo sapiens_hsa052172.17700033
11Spliceosome_Homo sapiens_hsa030402.17318593
12Galactose metabolism_Homo sapiens_hsa000521.97206403
13Arachidonic acid metabolism_Homo sapiens_hsa005901.91779004
14Cell cycle_Homo sapiens_hsa041101.90048145
15Hedgehog signaling pathway_Homo sapiens_hsa043401.83188280
16Homologous recombination_Homo sapiens_hsa034401.78699726
17Base excision repair_Homo sapiens_hsa034101.73572363
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.66254229
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.63752322
20Ribosome_Homo sapiens_hsa030101.61176781
21* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.60447421
22Cocaine addiction_Homo sapiens_hsa050301.60044989
23Hippo signaling pathway_Homo sapiens_hsa043901.59285924
24mTOR signaling pathway_Homo sapiens_hsa041501.56852393
25Thyroid cancer_Homo sapiens_hsa052161.53356610
26One carbon pool by folate_Homo sapiens_hsa006701.50058239
27Cardiac muscle contraction_Homo sapiens_hsa042601.49672414
28RNA degradation_Homo sapiens_hsa030181.47541601
29ECM-receptor interaction_Homo sapiens_hsa045121.47485560
30Notch signaling pathway_Homo sapiens_hsa043301.45951116
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.40571667
32Steroid biosynthesis_Homo sapiens_hsa001001.37618317
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.35787306
34p53 signaling pathway_Homo sapiens_hsa041151.31609687
35Linoleic acid metabolism_Homo sapiens_hsa005911.29313001
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.26364277
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.23267969
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.22873339
39RNA polymerase_Homo sapiens_hsa030201.22402312
40MicroRNAs in cancer_Homo sapiens_hsa052061.22322006
41Wnt signaling pathway_Homo sapiens_hsa043101.21685801
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19037431
43Nicotine addiction_Homo sapiens_hsa050331.16965035
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.15288815
45Nucleotide excision repair_Homo sapiens_hsa034201.13589027
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.06926606
47Basal transcription factors_Homo sapiens_hsa030221.06643135
48Pathways in cancer_Homo sapiens_hsa052001.06053302
49Dilated cardiomyopathy_Homo sapiens_hsa054141.01818174
50Adherens junction_Homo sapiens_hsa045200.97398634
51Insulin secretion_Homo sapiens_hsa049110.96254561
52Bladder cancer_Homo sapiens_hsa052190.95872009
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.95653468
54Huntingtons disease_Homo sapiens_hsa050160.94179965
55Thyroid hormone synthesis_Homo sapiens_hsa049180.91778509
56Gap junction_Homo sapiens_hsa045400.91204448
57Oxidative phosphorylation_Homo sapiens_hsa001900.90213668
58Biosynthesis of amino acids_Homo sapiens_hsa012300.89570854
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89388426
60Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88323001
61Parkinsons disease_Homo sapiens_hsa050120.87858081
62Dopaminergic synapse_Homo sapiens_hsa047280.87499824
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86184867
64Glutamatergic synapse_Homo sapiens_hsa047240.81334993
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80922365
66Estrogen signaling pathway_Homo sapiens_hsa049150.79857837
67Colorectal cancer_Homo sapiens_hsa052100.79618083
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79442162
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78612604
70Amphetamine addiction_Homo sapiens_hsa050310.75397932
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74003206
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73120264
73Pyrimidine metabolism_Homo sapiens_hsa002400.72978395
74Alzheimers disease_Homo sapiens_hsa050100.72853357
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.72560628
76Rap1 signaling pathway_Homo sapiens_hsa040150.72455015
77Acute myeloid leukemia_Homo sapiens_hsa052210.71226918
78GABAergic synapse_Homo sapiens_hsa047270.71087793
79Choline metabolism in cancer_Homo sapiens_hsa052310.69292969
80Tight junction_Homo sapiens_hsa045300.69147481
81HTLV-I infection_Homo sapiens_hsa051660.68975698
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67890150
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.67721200
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.67315978
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66773307
86Proteoglycans in cancer_Homo sapiens_hsa052050.66140432
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65979549
88Prion diseases_Homo sapiens_hsa050200.65489472
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65278239
90TGF-beta signaling pathway_Homo sapiens_hsa043500.64387304
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64242239
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64122472
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63444076
94Arginine and proline metabolism_Homo sapiens_hsa003300.62833088
95Circadian entrainment_Homo sapiens_hsa047130.62498242
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62190414
97Morphine addiction_Homo sapiens_hsa050320.61037251
98Bile secretion_Homo sapiens_hsa049760.60851941
99Cholinergic synapse_Homo sapiens_hsa047250.60340501
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60201367
101Herpes simplex infection_Homo sapiens_hsa051680.59284982
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58851065
103Prostate cancer_Homo sapiens_hsa052150.57751051
104Vitamin digestion and absorption_Homo sapiens_hsa049770.57726778
105Ovarian steroidogenesis_Homo sapiens_hsa049130.56941253
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56349197
107cAMP signaling pathway_Homo sapiens_hsa040240.55970582
108Other glycan degradation_Homo sapiens_hsa005110.55583208
109Inositol phosphate metabolism_Homo sapiens_hsa005620.55024079
110Glucagon signaling pathway_Homo sapiens_hsa049220.54833132
111Lysine degradation_Homo sapiens_hsa003100.54510908
112Insulin signaling pathway_Homo sapiens_hsa049100.54442133
113Vibrio cholerae infection_Homo sapiens_hsa051100.54378743
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53306774
115Synaptic vesicle cycle_Homo sapiens_hsa047210.52661232
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52308955
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52119447
118Non-small cell lung cancer_Homo sapiens_hsa052230.51646374
119Oocyte meiosis_Homo sapiens_hsa041140.51578524
120Small cell lung cancer_Homo sapiens_hsa052220.50027574
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49713575
122Pyruvate metabolism_Homo sapiens_hsa006200.48870803
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48575827
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47858230
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47332783
126Non-homologous end-joining_Homo sapiens_hsa034500.46770706
127Axon guidance_Homo sapiens_hsa043600.46402335
128Endometrial cancer_Homo sapiens_hsa052130.46386792
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44894369
130Taste transduction_Homo sapiens_hsa047420.44626750
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44022327
132VEGF signaling pathway_Homo sapiens_hsa043700.39594383
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39495435
134Sulfur relay system_Homo sapiens_hsa041220.38505133
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37816050
136AMPK signaling pathway_Homo sapiens_hsa041520.37277272
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37203575
138Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.35732499
139Ras signaling pathway_Homo sapiens_hsa040140.35512305
140Melanoma_Homo sapiens_hsa052180.35410759
141Viral carcinogenesis_Homo sapiens_hsa052030.34035932
142Protein digestion and absorption_Homo sapiens_hsa049740.33010250
143Neurotrophin signaling pathway_Homo sapiens_hsa047220.31801521
144Apoptosis_Homo sapiens_hsa042100.31726168
145Melanogenesis_Homo sapiens_hsa049160.30675732
146ErbB signaling pathway_Homo sapiens_hsa040120.29022663
147GnRH signaling pathway_Homo sapiens_hsa049120.25395260
148Focal adhesion_Homo sapiens_hsa045100.25345935
149Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24688352
150Pancreatic cancer_Homo sapiens_hsa052120.24469097
151Ether lipid metabolism_Homo sapiens_hsa005650.23299769
152MAPK signaling pathway_Homo sapiens_hsa040100.23196968
153Serotonergic synapse_Homo sapiens_hsa047260.21539098
154Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21336968

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