PCGF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a C3HC4 type RING finger, which is a motif known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K36 demethylation (GO:0070544)4.50546587
2hippo signaling (GO:0035329)4.27337595
3chondrocyte proliferation (GO:0035988)4.06931745
4histone H3-K9 demethylation (GO:0033169)3.84913155
5plasma membrane repair (GO:0001778)3.79486031
6polarized epithelial cell differentiation (GO:0030859)3.74196582
7histone lysine demethylation (GO:0070076)3.70996811
8paraxial mesoderm development (GO:0048339)3.68206348
9regulation of NFAT protein import into nucleus (GO:0051532)3.66880447
10histone H3-K4 trimethylation (GO:0080182)3.66592917
11axon extension involved in axon guidance (GO:0048846)3.65588991
12neuron projection extension involved in neuron projection guidance (GO:1902284)3.65588991
13negative regulation of erythrocyte differentiation (GO:0045647)3.60245374
14histone demethylation (GO:0016577)3.51411436
15positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.51150816
16mannose metabolic process (GO:0006013)3.47217173
17cytoplasmic mRNA processing body assembly (GO:0033962)3.43198717
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.34176037
19planar cell polarity pathway involved in neural tube closure (GO:0090179)3.32996900
20regulation of hippo signaling (GO:0035330)3.28830341
21cell migration in hindbrain (GO:0021535)3.26027467
22regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.25243172
23negative regulation of chondrocyte differentiation (GO:0032331)3.19996023
24negative regulation of catenin import into nucleus (GO:0035414)3.17323455
25regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.16323802
26regulation of ARF GTPase activity (GO:0032312)3.16071162
27cell adhesion mediated by integrin (GO:0033627)3.13999859
28insulin-like growth factor receptor signaling pathway (GO:0048009)3.13730720
29regulation of ARF protein signal transduction (GO:0032012)3.10949492
30cell-cell junction maintenance (GO:0045217)3.10673816
31gastrulation with mouth forming second (GO:0001702)3.08723518
32negative regulation of fatty acid transport (GO:2000192)3.08324547
33pre-miRNA processing (GO:0031054)3.03736221
34protein demethylation (GO:0006482)3.01183328
35protein dealkylation (GO:0008214)3.01183328
36response to muramyl dipeptide (GO:0032495)3.00511079
37stress granule assembly (GO:0034063)2.95736554
38craniofacial suture morphogenesis (GO:0097094)2.93286654
39regulation of histone H3-K27 methylation (GO:0061085)2.91542222
40endocardial cushion development (GO:0003197)2.88359868
41collagen fibril organization (GO:0030199)2.86589255
42regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.83419014
43dorsal/ventral axis specification (GO:0009950)2.79300421
44axon extension (GO:0048675)2.78952627
45positive regulation of SMAD protein import into nucleus (GO:0060391)2.77736072
46epithelial cell-cell adhesion (GO:0090136)2.75982984
47dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.75106177
48cytoskeletal anchoring at plasma membrane (GO:0007016)2.72594042
49histone H3-K9 modification (GO:0061647)2.72505488
50adherens junction assembly (GO:0034333)2.71762967
51regulation of SMAD protein import into nucleus (GO:0060390)2.71211843
52endodermal cell differentiation (GO:0035987)2.69259740
53cell migration involved in sprouting angiogenesis (GO:0002042)2.67326547
54camera-type eye morphogenesis (GO:0048593)2.66234392
55histone H4 deacetylation (GO:0070933)2.65956088
56semaphorin-plexin signaling pathway (GO:0071526)2.65930699
57body morphogenesis (GO:0010171)2.64869584
58mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.62625897
59histone H3-K9 methylation (GO:0051567)2.61966439
60heterochromatin organization (GO:0070828)2.61522935
61bone trabecula formation (GO:0060346)2.60912596
62glucocorticoid receptor signaling pathway (GO:0042921)2.60530532
63mesenchymal-epithelial cell signaling (GO:0060638)2.60128248
64hemidesmosome assembly (GO:0031581)2.58266754
65mesodermal cell differentiation (GO:0048333)2.58194000
66NLS-bearing protein import into nucleus (GO:0006607)2.56884416
67metanephric mesenchyme development (GO:0072075)2.56649425
68establishment of monopolar cell polarity (GO:0061162)2.56197856
69establishment or maintenance of monopolar cell polarity (GO:0061339)2.56197856
70negative regulation of histone methylation (GO:0031061)2.54889216
71histone H3-K4 methylation (GO:0051568)2.54422553
72protein localization to cell surface (GO:0034394)2.53486946
73embryonic process involved in female pregnancy (GO:0060136)2.52968970
74regulation of tight junction assembly (GO:2000810)2.50409046
75glial cell proliferation (GO:0014009)2.49070639
76sequestering of extracellular ligand from receptor (GO:0035581)2.48938479
77cell-substrate junction assembly (GO:0007044)2.48588708
78intracellular estrogen receptor signaling pathway (GO:0030520)2.48067880
79mitotic sister chromatid cohesion (GO:0007064)2.47066716
80negative regulation of cartilage development (GO:0061037)2.46815746
81nuclear pore complex assembly (GO:0051292)2.46711154
82protein heterotrimerization (GO:0070208)2.46059952
83epithelial cell differentiation involved in prostate gland development (GO:0060742)2.45410125
84notochord development (GO:0030903)2.45297020
85positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.45198911
86atrial septum morphogenesis (GO:0060413)2.45128174
87ganglion development (GO:0061548)2.43454455
88adherens junction organization (GO:0034332)2.43351744
89regulation of transforming growth factor beta2 production (GO:0032909)2.42065671
90embryonic cranial skeleton morphogenesis (GO:0048701)2.41887815
91mesenchyme development (GO:0060485)2.41737867
92lung-associated mesenchyme development (GO:0060484)2.41212563
93regulation of catenin import into nucleus (GO:0035412)2.40947610
943-UTR-mediated mRNA stabilization (GO:0070935)2.40923858
95embryonic foregut morphogenesis (GO:0048617)2.40711981
96histone lysine methylation (GO:0034968)2.39989645
97coronary vasculature morphogenesis (GO:0060977)2.39091770
98establishment of apical/basal cell polarity (GO:0035089)2.38700549
99kidney mesenchyme development (GO:0072074)2.38565783
100negative regulation of myotube differentiation (GO:0010832)2.38522343
101neuron projection extension (GO:1990138)2.38152508
102heart valve formation (GO:0003188)2.38142494
103myoblast fusion (GO:0007520)2.37351122
104dosage compensation (GO:0007549)2.37145913
105regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.36801917
106establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.36703712
107embryonic viscerocranium morphogenesis (GO:0048703)2.35910577
108regulation of nucleobase-containing compound transport (GO:0032239)2.35589829
109regulation of heart morphogenesis (GO:2000826)2.35587689
110peptidyl-lysine dimethylation (GO:0018027)2.35141902
111cell junction maintenance (GO:0034331)2.34938461
112germ cell migration (GO:0008354)2.34582959
113regulation of RNA export from nucleus (GO:0046831)2.34433720
114respiratory tube development (GO:0030323)2.34153297
115positive regulation of hormone biosynthetic process (GO:0046886)2.33852550
116cardiac myofibril assembly (GO:0055003)2.33669042
117syncytium formation (GO:0006949)2.33492701
118peptidyl-lysine trimethylation (GO:0018023)2.33339783
119embryonic body morphogenesis (GO:0010172)2.32327251
120cartilage morphogenesis (GO:0060536)2.32047341
121negative chemotaxis (GO:0050919)2.31895790
122layer formation in cerebral cortex (GO:0021819)2.31644193
123neuron remodeling (GO:0016322)2.31122453
124midgut development (GO:0007494)2.30758289
125establishment of nucleus localization (GO:0040023)2.30665404
126cell-substrate adherens junction assembly (GO:0007045)2.29896662
127focal adhesion assembly (GO:0048041)2.29896662
128proximal/distal pattern formation (GO:0009954)2.29871889
129regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.29866421
130peptidyl-threonine phosphorylation (GO:0018107)2.28971904
131face development (GO:0060324)2.28832743
132chondrocyte development (GO:0002063)2.28768961
133Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.28623265
134regulation of establishment of planar polarity (GO:0090175)2.28441589
135skin morphogenesis (GO:0043589)2.27882165
136G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.27098161
137dendrite morphogenesis (GO:0048813)2.26357072
138wound healing, spreading of epidermal cells (GO:0035313)2.26264460
139ectodermal placode formation (GO:0060788)2.25919712
140peptidyl-threonine modification (GO:0018210)2.25343656
141positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.25202030
142negative regulation of DNA repair (GO:0045738)2.25157283
143positive regulation of CREB transcription factor activity (GO:0032793)2.25056324
144regulation of glucose import in response to insulin stimulus (GO:2001273)2.23416782
145regulation of chondrocyte differentiation (GO:0032330)2.23243210
146basement membrane organization (GO:0071711)2.23089047
147positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.21034842
148embryonic camera-type eye morphogenesis (GO:0048596)2.19529500
149mRNA stabilization (GO:0048255)2.19184174
150RNA stabilization (GO:0043489)2.19184174
151eye morphogenesis (GO:0048592)2.19159585
152cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.18324710
153cranial nerve morphogenesis (GO:0021602)2.17391220
154response to laminar fluid shear stress (GO:0034616)2.14703554
155histone H3 deacetylation (GO:0070932)2.14023851
156positive regulation of dendritic spine morphogenesis (GO:0061003)2.11520420
157atrioventricular valve morphogenesis (GO:0003181)2.10881398
158negative regulation of cell size (GO:0045792)2.07107405
159peptidyl-lysine methylation (GO:0018022)2.06936137
160negative regulation of Ras protein signal transduction (GO:0046580)2.06555842
161regulation of phosphatidylinositol 3-kinase activity (GO:0043551)2.06492179
162positive regulation of dendrite morphogenesis (GO:0050775)2.06077438
163negative regulation of glial cell proliferation (GO:0060253)2.04183032
164establishment of spindle orientation (GO:0051294)2.03975273
165germinal center formation (GO:0002467)2.02253131
166regulation of lipid kinase activity (GO:0043550)2.01436245
167regulation of monocyte differentiation (GO:0045655)1.98236749
168positive regulation of blood vessel endothelial cell migration (GO:0043536)1.97516960
169endothelial cell chemotaxis (GO:0035767)1.97407758
170heart morphogenesis (GO:0003007)1.96391340
171positive regulation of Rap GTPase activity (GO:0032854)1.96145691
172embryonic retina morphogenesis in camera-type eye (GO:0060059)1.96054548
173positive regulation of Cdc42 GTPase activity (GO:0043089)1.95983755
174barbed-end actin filament capping (GO:0051016)1.95888835
175retrograde transport, endosome to Golgi (GO:0042147)1.95638931
176positive regulation of gene expression, epigenetic (GO:0045815)1.95613085
177establishment of mitochondrion localization, microtubule-mediated (GO:0034643)1.95455478
178mitochondrion transport along microtubule (GO:0047497)1.95455478
179negative regulation of small GTPase mediated signal transduction (GO:0051058)1.95307615
180response to fluid shear stress (GO:0034405)1.94131888
181SMAD protein complex assembly (GO:0007183)1.94040185
182protein-DNA complex disassembly (GO:0032986)1.92129802
183nucleosome disassembly (GO:0006337)1.92129802

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.59164484
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.98925717
3KDM2B_26808549_Chip-Seq_SUP-B15_Human3.00069358
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.96800949
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.95348686
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.88910443
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.57696731
8KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.57336472
9TCF7_22412390_ChIP-Seq_EML_Mouse2.50567298
10VDR_21846776_ChIP-Seq_THP-1_Human2.50261174
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.44728353
12MYC_22102868_ChIP-Seq_BL_Human2.39511700
13TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.37800422
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.34282527
15HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.24353894
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.22280503
17WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.20421509
18KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.13739565
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13271655
20WT1_19549856_ChIP-ChIP_CCG9911_Human2.13146808
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.13143273
22SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.13069381
23ELK3_25401928_ChIP-Seq_HUVEC_Human2.05501481
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.99766829
25* LXR_22292898_ChIP-Seq_THP-1_Human1.92339476
26CLOCK_20551151_ChIP-Seq_293T_Human1.88419006
27* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.85076462
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.83475345
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.83417009
30SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.82477563
31EZH2_22144423_ChIP-Seq_EOC_Human1.80812993
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80767726
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.79521314
34FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.71491477
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.71054366
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70929565
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.70607846
38DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.69320699
39* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.68474359
40RACK7_27058665_Chip-Seq_MCF-7_Human1.67788013
41DROSHA_22980978_ChIP-Seq_HELA_Human1.66978272
42ISL1_27105846_Chip-Seq_CPCs_Mouse1.66545635
43BRD4_25478319_ChIP-Seq_HGPS_Human1.66473716
44ZFP281_27345836_Chip-Seq_ESCs_Mouse1.63455899
45EP300_21415370_ChIP-Seq_HL-1_Mouse1.62173654
46ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.61615116
47TP53_16413492_ChIP-PET_HCT116_Human1.61440645
48P300_27058665_Chip-Seq_ZR-75-30cells_Human1.60388423
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57821312
50VDR_24763502_ChIP-Seq_THP-1_Human1.57533801
51HIF1A_21447827_ChIP-Seq_MCF-7_Human1.56421421
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.56211330
53SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.53272150
54SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.53272150
55TCF4_18268006_ChIP-ChIP_LS174T_Human1.52286388
56ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.51485404
57CREB1_26743006_Chip-Seq_LNCaP_Human1.50756433
58RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.50643354
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48630064
60RUNX1_27514584_Chip-Seq_MCF-7_Human1.48621409
61ESR1_20079471_ChIP-ChIP_T-47D_Human1.45753578
62ZNF274_21170338_ChIP-Seq_K562_Hela1.42991908
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.42053394
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41019769
65SALL4_18804426_ChIP-ChIP_XEN_Mouse1.37932843
66PPAR_26484153_Chip-Seq_NCI-H1993_Human1.37793706
67* TP53_20018659_ChIP-ChIP_R1E_Mouse1.37513536
68CJUN_26792858_Chip-Seq_BT549_Human1.34570741
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34438161
70MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.32508809
71EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32176753
72CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.31750140
73RING1B_27294783_Chip-Seq_NPCs_Mouse1.31227865
74CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28857766
75RARB_27405468_Chip-Seq_BRAIN_Mouse1.28533098
76CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28165038
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27717332
78NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.27170908
79DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25294859
80KDM2B_26808549_Chip-Seq_K562_Human1.24978027
81EZH2_18974828_ChIP-Seq_MESCs_Mouse1.24859106
82RNF2_18974828_ChIP-Seq_MESCs_Mouse1.24859106
83SMC4_20622854_ChIP-Seq_HELA_Human1.23711642
84FOXO3_23340844_ChIP-Seq_DLD1_Human1.22268890
85SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.20822978
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20754727
87GATA1_19941827_ChIP-Seq_MEL_Mouse1.20711074
88SOX9_24532713_ChIP-Seq_HFSC_Mouse1.20589690
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19503088
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14777433
91ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14762558
92TP53_18474530_ChIP-ChIP_U2OS_Human1.13761104
93MAF_26560356_Chip-Seq_TH1_Human1.12409497
94GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12286878
95OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.11914240
96CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10870387
97KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10818651
98KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10818651
99KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10818651
100ESR1_21235772_ChIP-Seq_MCF-7_Human1.10779903
101TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10646440
102UTX_26944678_Chip-Seq_JUKART_Human1.10466105
103TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09346768
104RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09335581
105CTCF_27219007_Chip-Seq_Bcells_Human1.09141436
106FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09107921
107NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.08210961
108WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07898186
109MAF_26560356_Chip-Seq_TH2_Human1.07547949
110E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07316369
111AHR_22903824_ChIP-Seq_MCF-7_Human1.07260321
112RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07116910
113AR_21909140_ChIP-Seq_LNCAP_Human1.07081549
114YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07042854
115MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.06612383
116ESR2_21235772_ChIP-Seq_MCF-7_Human1.06436896
117UBF1/2_26484160_Chip-Seq_HMECs_Human1.06336727
118SA1_27219007_Chip-Seq_ERYTHROID_Human1.05440860
119ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05312360
120IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05248909
121SMAD_19615063_ChIP-ChIP_OVARY_Human1.04834597
122KDM2B_26808549_Chip-Seq_JURKAT_Human1.04410110
123NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04151572
124SCL_19346495_ChIP-Seq_HPC-7_Human1.03430195
125POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.03234276
126CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02878907
127ARNT_22903824_ChIP-Seq_MCF-7_Human1.01071104
128TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00567679
129HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99502151
130FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99468997
131CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99175345
132CHD1_26751641_Chip-Seq_LNCaP_Human0.98949998
133TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98090805
134SPI1_23127762_ChIP-Seq_K562_Human0.97661771
135RNF2_27304074_Chip-Seq_ESCs_Mouse0.97575435
136ZNF263_19887448_ChIP-Seq_K562_Human0.97477505
137FOXA2_19822575_ChIP-Seq_HepG2_Human0.97219541
138EED_16625203_ChIP-ChIP_MESCs_Mouse0.96515394
139ATF3_27146783_Chip-Seq_COLON_Human0.95791360
140NCOR1_26117541_ChIP-Seq_K562_Human0.95634492
141KDM2B_26808549_Chip-Seq_DND41_Human0.95308401
142TCF3_18692474_ChIP-Seq_MESCs_Mouse0.95274765
143SUZ12_27294783_Chip-Seq_ESCs_Mouse0.94911147
144MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.94860658
145CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94470329
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94307756
147TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93749584
148TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.93382223
149NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93299066
150* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93115324
151UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92868431
152PKCTHETA_26484144_Chip-Seq_BREAST_Human0.92719443
153P68_20966046_ChIP-Seq_HELA_Human0.92476993
154TBX20_22080862_ChIP-Seq_HEART_Mouse0.90993113
155TBX20_22328084_ChIP-Seq_HEART_Mouse0.90993113
156SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90984167

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.85971586
2MP0005409_darkened_coat_color3.74964197
3MP0008438_abnormal_cutaneous_collagen3.12108332
4MP0002009_preneoplasia2.85101249
5MP0010352_gastrointestinal_tract_polyps2.60233294
6MP0010030_abnormal_orbit_morphology2.58694856
7MP0009053_abnormal_anal_canal2.56100192
8MP0000569_abnormal_digit_pigmentation2.51466276
9MP0000537_abnormal_urethra_morphology2.44547674
10MP0005623_abnormal_meninges_morphology2.40866893
11MP0003385_abnormal_body_wall2.29661689
12MP0005275_abnormal_skin_tensile2.26655964
13MP0003941_abnormal_skin_development2.26000728
14MP0005076_abnormal_cell_differentiation2.22908137
15MP0004859_abnormal_synaptic_plasticity2.18483615
16MP0000733_abnormal_muscle_development2.10854443
17MP0009278_abnormal_bone_marrow1.94287412
18MP0005451_abnormal_body_composition1.90886149
19MP0003300_gastrointestinal_ulcer1.88331734
20MP0004272_abnormal_basement_membrane1.86061117
21MP0004264_abnormal_extraembryonic_tissu1.85491028
22MP0005503_abnormal_tendon_morphology1.77599684
23MP0003303_peritoneal_inflammation1.76695149
24MP0003937_abnormal_limbs/digits/tail_de1.72970166
25MP0003942_abnormal_urinary_system1.72643317
26MP0001299_abnormal_eye_distance/1.72432177
27MP0000428_abnormal_craniofacial_morphol1.71573634
28MP0003566_abnormal_cell_adhesion1.68875192
29MP0003755_abnormal_palate_morphology1.67524719
30MP0003453_abnormal_keratinocyte_physiol1.66882234
31MP0010234_abnormal_vibrissa_follicle1.64981717
32MP0009250_abnormal_appendicular_skeleto1.63938295
33MP0000566_synostosis1.62719321
34MP0003935_abnormal_craniofacial_develop1.62408230
35MP0001849_ear_inflammation1.61072266
36MP0005248_abnormal_Harderian_gland1.57537406
37MP0000534_abnormal_ureter_morphology1.54057389
38MP0005187_abnormal_penis_morphology1.49491241
39MP0008004_abnormal_stomach_pH1.49274861
40MP0005257_abnormal_intraocular_pressure1.46900627
41MP0008260_abnormal_autophagy1.46211368
42MP0003890_abnormal_embryonic-extraembry1.45613840
43MP0009384_cardiac_valve_regurgitation1.44487703
44MP0004197_abnormal_fetal_growth/weight/1.42112353
45MP0002896_abnormal_bone_mineralization1.42075790
46MP0005666_abnormal_adipose_tissue1.41973058
47MP0003115_abnormal_respiratory_system1.40900084
48MP0010368_abnormal_lymphatic_system1.40385983
49MP0001348_abnormal_lacrimal_gland1.39890619
50MP0000432_abnormal_head_morphology1.39837831
51MP0002249_abnormal_larynx_morphology1.39080776
52MP0003091_abnormal_cell_migration1.38281265
53MP0003119_abnormal_digestive_system1.36984097
54MP0002233_abnormal_nose_morphology1.35365445
55MP0003787_abnormal_imprinting1.34882061
56MP0003567_abnormal_fetal_cardiomyocyte1.33942644
57MP0005058_abnormal_lysosome_morphology1.33584261
58MP0005394_taste/olfaction_phenotype1.32499880
59MP0005499_abnormal_olfactory_system1.32499880
60MP0002796_impaired_skin_barrier1.32499081
61MP0001879_abnormal_lymphatic_vessel1.31492068
62MP0003123_paternal_imprinting1.31204711
63MP0002932_abnormal_joint_morphology1.30350323
64MP0003329_amyloid_beta_deposits1.29560472
65MP0002084_abnormal_developmental_patter1.28339625
66MP0003279_aneurysm1.26416539
67MP0006054_spinal_hemorrhage1.25322239
68MP0004858_abnormal_nervous_system1.24756982
69MP0004947_skin_inflammation1.24066370
70MP0003828_pulmonary_edema1.23307976
71MP0002822_catalepsy1.22101167
72MP0005367_renal/urinary_system_phenotyp1.20920350
73MP0000516_abnormal_urinary_system1.20920350
74MP0002116_abnormal_craniofacial_bone1.20876202
75MP0000049_abnormal_middle_ear1.20409873
76MP0005508_abnormal_skeleton_morphology1.20148525
77MP0003121_genomic_imprinting1.19778519
78MP0003122_maternal_imprinting1.18489843
79MP0004233_abnormal_muscle_weight1.17493347
80MP0002089_abnormal_postnatal_growth/wei1.17251077
81MP0003436_decreased_susceptibility_to1.17140689
82MP0000762_abnormal_tongue_morphology1.16746806
83MP0003172_abnormal_lysosome_physiology1.16429249
84MP0006138_congestive_heart_failure1.16111770
85MP0002177_abnormal_outer_ear1.15309790
86MP0000750_abnormal_muscle_regeneration1.15260362
87MP0009780_abnormal_chondrocyte_physiolo1.14115561
88MP0001293_anophthalmia1.13383807
89MP0000678_abnormal_parathyroid_gland1.12972026
90MP0002085_abnormal_embryonic_tissue1.11454412
91MP0010678_abnormal_skin_adnexa1.09229295
92MP0002697_abnormal_eye_size1.08657103
93MP0004087_abnormal_muscle_fiber1.08438720
94MP0002282_abnormal_trachea_morphology1.07411891
95MP0002998_abnormal_bone_remodeling1.05907369
96MP0002111_abnormal_tail_morphology1.05295257
97MP0002109_abnormal_limb_morphology1.03889174
98MP0005375_adipose_tissue_phenotype1.03147706
99MP0002925_abnormal_cardiovascular_devel1.01326907
100MP0004808_abnormal_hematopoietic_stem1.01120252
101MP0004084_abnormal_cardiac_muscle1.00236075
102MP0002060_abnormal_skin_morphology0.99661263
103MP0003315_abnormal_perineum_morphology0.99523610
104MP0009115_abnormal_fat_cell0.99498732
105MP0000163_abnormal_cartilage_morphology0.98299902
106MP0002086_abnormal_extraembryonic_tissu0.98203606
107MP0000751_myopathy0.98149946
108MP0005023_abnormal_wound_healing0.97798793
109MP0000778_abnormal_nervous_system0.97685605
110MP0002115_abnormal_skeleton_extremities0.97040119
111MP0005380_embryogenesis_phenotype0.96703404
112MP0001672_abnormal_embryogenesis/_devel0.96703404
113MP0002088_abnormal_embryonic_growth/wei0.96046682
114MP0001188_hyperpigmentation0.95581941
115MP0008961_abnormal_basal_metabolism0.95469107
116MP0004130_abnormal_muscle_cell0.94971578
117MP0003861_abnormal_nervous_system0.94956043
118MP0009703_decreased_birth_body0.94691797
119MP0003948_abnormal_gas_homeostasis0.94464360
120MP0010630_abnormal_cardiac_muscle0.94014755
121MP0003984_embryonic_growth_retardation0.93990642
122MP0002938_white_spotting0.93946716
123MP0002877_abnormal_melanocyte_morpholog0.93339421
124MP0002234_abnormal_pharynx_morphology0.92568892
125MP0002092_abnormal_eye_morphology0.92442140
126MP0000467_abnormal_esophagus_morphology0.91937622
127MP0004185_abnormal_adipocyte_glucose0.91855992
128MP0001286_abnormal_eye_development0.90515796
129MP0004270_analgesia0.89297191
130MP0001958_emphysema0.89187728
131MP0009672_abnormal_birth_weight0.89081207
132MP0000383_abnormal_hair_follicle0.87611663
133MP0000767_abnormal_smooth_muscle0.87451838
134MP0002114_abnormal_axial_skeleton0.86560992
135MP0000759_abnormal_skeletal_muscle0.86052940
136MP0002396_abnormal_hematopoietic_system0.84827920
137MP0000579_abnormal_nail_morphology0.84659716
138MP0002081_perinatal_lethality0.83962519
139MP0001502_abnormal_circadian_rhythm0.83527019
140MP0001270_distended_abdomen0.82400065
141MP0001614_abnormal_blood_vessel0.82339363
142MP0004510_myositis0.81276309
143MP0002108_abnormal_muscle_morphology0.81191793
144MP0002152_abnormal_brain_morphology0.80306396
145MP0001915_intracranial_hemorrhage0.78968470
146MP0003938_abnormal_ear_development0.77436709
147MP0003183_abnormal_peptide_metabolism0.76323439
148MP0002127_abnormal_cardiovascular_syste0.75824489
149MP0000955_abnormal_spinal_cord0.75378658
150MP0004811_abnormal_neuron_physiology0.75343664
151MP0002184_abnormal_innervation0.72030149
152MP0005397_hematopoietic_system_phenotyp0.71559053
153MP0001545_abnormal_hematopoietic_system0.71559053
154MP0008995_early_reproductive_senescence0.71314766

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.45084608
2Shallow orbits (HP:0000586)4.00768890
3Premature rupture of membranes (HP:0001788)3.74809502
4Obstructive sleep apnea (HP:0002870)3.34267546
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.08790599
6Short 4th metacarpal (HP:0010044)3.08790599
7Abnormality of the fingertips (HP:0001211)2.98529828
8Vertebral arch anomaly (HP:0008438)2.97119153
9Broad face (HP:0000283)2.94876447
10Atrophic scars (HP:0001075)2.88835637
11Ankle contracture (HP:0006466)2.84729774
12Flat acetabular roof (HP:0003180)2.76319071
13Wrist flexion contracture (HP:0001239)2.72464222
14Abnormality of the aortic arch (HP:0012303)2.54953209
15Abnormality of the 4th metacarpal (HP:0010012)2.54803272
16Turricephaly (HP:0000262)2.47393138
17Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.42606940
18Type 1 muscle fiber predominance (HP:0003803)2.41806253
19Right ventricular cardiomyopathy (HP:0011663)2.41390878
20Mitral valve prolapse (HP:0001634)2.41263582
21Subacute progressive viral hepatitis (HP:0006572)2.40112215
22Hypoplastic ischia (HP:0003175)2.38931700
23Renal duplication (HP:0000075)2.34074726
24Abnormality of the thoracic spine (HP:0100711)2.33788274
25Aortic dissection (HP:0002647)2.33765113
26Germ cell neoplasia (HP:0100728)2.31477318
27Genu recurvatum (HP:0002816)2.30601222
28Bladder diverticulum (HP:0000015)2.30057852
29Cerebral aneurysm (HP:0004944)2.29776264
30Dilatation of the ascending aorta (HP:0005111)2.26923850
31Abnormality of the distal phalanx of the thumb (HP:0009617)2.23288345
32Lymphangioma (HP:0100764)2.21135118
33Increased connective tissue (HP:0009025)2.20967222
34Pelvic girdle muscle weakness (HP:0003749)2.20462896
35Aortic aneurysm (HP:0004942)2.19336466
36Papilledema (HP:0001085)2.19080149
37Rectal prolapse (HP:0002035)2.18810245
38Deep palmar crease (HP:0006191)2.18727201
39Truncal obesity (HP:0001956)2.18038566
40Coronal craniosynostosis (HP:0004440)2.17741921
41High anterior hairline (HP:0009890)2.14699201
42Broad palm (HP:0001169)2.14509158
43Overgrowth (HP:0001548)2.13954242
44Hepatoblastoma (HP:0002884)2.12742323
45Thoracic kyphosis (HP:0002942)2.09811193
46Macroorchidism (HP:0000053)2.08910108
47Neoplasm of the heart (HP:0100544)2.05652038
48Trigonocephaly (HP:0000243)2.04935156
49Fragile skin (HP:0001030)2.02284473
50Buphthalmos (HP:0000557)2.01941441
51Pointed chin (HP:0000307)2.01616618
52Mildly elevated creatine phosphokinase (HP:0008180)2.00903231
53Broad metatarsal (HP:0001783)2.00568807
54Deviation of the hallux (HP:0010051)2.00296602
55Neonatal hypoglycemia (HP:0001998)1.99693833
56Metaphyseal cupping (HP:0003021)1.99424260
57Shoulder girdle muscle weakness (HP:0003547)1.99416818
58Scapular winging (HP:0003691)1.99316981
59Abnormality of the ischium (HP:0003174)1.97785577
60Disproportionate tall stature (HP:0001519)1.96975743
61Difficulty climbing stairs (HP:0003551)1.96565755
62Precocious puberty (HP:0000826)1.96051876
63Asymmetry of the thorax (HP:0001555)1.95997411
64Dislocated radial head (HP:0003083)1.95384492
65Mitral regurgitation (HP:0001653)1.95184971
66Peritonitis (HP:0002586)1.95130246
67Cervical subluxation (HP:0003308)1.94344110
68Mesomelia (HP:0003027)1.94330701
69Hallux valgus (HP:0001822)1.93168211
70Genetic anticipation (HP:0003743)1.91576970
71Microglossia (HP:0000171)1.90658088
72Enlarged penis (HP:0000040)1.89982595
73Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.89366915
74Blue sclerae (HP:0000592)1.88166502
75Long palpebral fissure (HP:0000637)1.87584694
76Wormian bones (HP:0002645)1.87402292
77Hip contracture (HP:0003273)1.87105096
78Ankyloglossia (HP:0010296)1.86685864
79Abnormality of the hip-girdle musculature (HP:0001445)1.86346009
80Abnormality of the musculature of the pelvis (HP:0001469)1.86346009
81Bowel diverticulosis (HP:0005222)1.86094280
82Soft skin (HP:0000977)1.85823440
83Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.83176258
84Spinal rigidity (HP:0003306)1.83089328
85Cupped ribs (HP:0000887)1.83001635
86Selective tooth agenesis (HP:0001592)1.81255852
87Neurofibrillary tangles (HP:0002185)1.78316592
88Renovascular hypertension (HP:0100817)1.77960920
89Visceral angiomatosis (HP:0100761)1.77793536
90Limb-girdle muscle weakness (HP:0003325)1.77567629
91Arterial tortuosity (HP:0005116)1.77452513
92Thick eyebrow (HP:0000574)1.77225265
93Abnormality of the radial head (HP:0003995)1.76900128
94Bell-shaped thorax (HP:0001591)1.76403195
95Broad thumb (HP:0011304)1.75856966
96Hemangiomatosis (HP:0007461)1.75614855
97Cerebral inclusion bodies (HP:0100314)1.75378579
98Cortical dysplasia (HP:0002539)1.75350063
99Increased density of long bones (HP:0006392)1.74706498
100Hyperacusis (HP:0010780)1.73856546
101Joint laxity (HP:0001388)1.73293711
102Obsessive-compulsive behavior (HP:0000722)1.71407672
103Spina bifida occulta (HP:0003298)1.70856627
104Thin bony cortex (HP:0002753)1.70653400
105Spinal cord lesions (HP:0100561)1.69876934
106Syringomyelia (HP:0003396)1.69876934
107Wide anterior fontanel (HP:0000260)1.69784899
108Hyporeflexia of lower limbs (HP:0002600)1.69392080
109Abnormality of incisor morphology (HP:0011063)1.69083273
110Bowel incontinence (HP:0002607)1.68954923
111Exostoses (HP:0100777)1.68860662
112Abnormality of dentin (HP:0010299)1.68807589
113Hyperextensible skin (HP:0000974)1.68726120
114Ulnar bowing (HP:0003031)1.68640303
115Abnormality of the calcaneus (HP:0008364)1.68271297
116Narrow palate (HP:0000189)1.67950967
117Eczematoid dermatitis (HP:0000976)1.67387470
118Spinal canal stenosis (HP:0003416)1.66262003
119Knee flexion contracture (HP:0006380)1.66020565
120Round ear (HP:0100830)1.65644494
121Abnormality of the columella (HP:0009929)1.65151953
122Hypoplastic labia majora (HP:0000059)1.64795615
123Tapered finger (HP:0001182)1.64339849
124Arnold-Chiari malformation (HP:0002308)1.63910086
125Vitreoretinal degeneration (HP:0000655)1.63442915
126Dysmetric saccades (HP:0000641)1.62787803
127Supernumerary ribs (HP:0005815)1.62613531
128Difficulty running (HP:0009046)1.62140380
129Abnormality of the peritoneum (HP:0002585)1.61744722
130Deviation of the thumb (HP:0009603)1.61563535
131Bronchomalacia (HP:0002780)1.61173957
132Cutaneous finger syndactyly (HP:0010554)1.61165053
133Neonatal short-limb short stature (HP:0008921)1.60897161
134Aneurysm (HP:0002617)1.60825850
135Insomnia (HP:0100785)1.60369189
136Limited hip movement (HP:0008800)1.60026093
137Skull defect (HP:0001362)1.59196248
138Abnormality of the labia majora (HP:0012881)1.58893205
139Advanced eruption of teeth (HP:0006288)1.58739934
140Follicular hyperkeratosis (HP:0007502)1.58454826
141Back pain (HP:0003418)1.58321722
142Abnormality of the pubic bones (HP:0003172)1.56604104
143Heterotopia (HP:0002282)1.56512197
144Broad ribs (HP:0000885)1.55697480
145Alopecia of scalp (HP:0002293)1.55119888
146Abnormality of the astrocytes (HP:0100707)1.54810311
147Astrocytoma (HP:0009592)1.54810311
148Curly hair (HP:0002212)1.54302130
149Infantile muscular hypotonia (HP:0008947)1.54253497
150Onion bulb formation (HP:0003383)1.54078594
151Colitis (HP:0002583)1.53136800
152Tibial bowing (HP:0002982)1.53126210
153Vascular tortuosity (HP:0004948)1.52988247
154Cubitus valgus (HP:0002967)1.52817456
155Increased variability in muscle fiber diameter (HP:0003557)1.52625021
156Broad long bones (HP:0005622)1.52514566
157Lower limb amyotrophy (HP:0007210)1.52408902
158Hypoplasia of the maxilla (HP:0000327)1.51642135
159Long eyelashes (HP:0000527)1.51571472
160Midline defect of the nose (HP:0004122)1.51061434
161Hemorrhage of the eye (HP:0011885)1.49779221
162Increased IgE level (HP:0003212)1.49571319
163Papillary thyroid carcinoma (HP:0002895)1.48295900
164Stereotypic behavior (HP:0000733)1.48184607
165Spontaneous hematomas (HP:0007420)1.47718899
166Biconcave vertebral bodies (HP:0004586)1.47117385
167Supranuclear gaze palsy (HP:0000605)1.45435832
168Acute lymphatic leukemia (HP:0006721)1.45377454
169Sporadic (HP:0003745)1.44422649
170Aplasia involving bones of the extremities (HP:0009825)1.44237094
171Aplasia involving bones of the upper limbs (HP:0009823)1.44237094
172Aplasia of the phalanges of the hand (HP:0009802)1.44237094
173Annular pancreas (HP:0001734)1.44142944

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.83927292
2LATS23.00524187
3TRIB32.94694864
4PKN22.76963764
5CDK122.74744581
6TTN2.65185740
7DDR22.54997056
8PDGFRA2.40827931
9MAP3K132.28717877
10RIPK12.27437545
11EPHB22.26187764
12MARK12.25027847
13FGFR42.13874407
14PRPF4B2.11048223
15MAP3K101.98689071
16ERBB31.95782804
17EPHA21.84263055
18SIK11.79614630
19EEF2K1.79152989
20FER1.68375080
21PAK31.63121333
22DMPK1.58006165
23MAP3K61.52042609
24AKT31.49041777
25PTK61.45615720
26NEK11.45234542
27FGFR31.39575087
28MET1.38688958
29PTK21.35968228
30CDK61.35776243
31STK31.35424180
32MTOR1.34740994
33SGK31.33922609
34SGK21.33046732
35KSR11.28687371
36SGK4941.27451236
37SGK2231.27451236
38PHKG21.23388939
39PHKG11.23388939
40TNK21.17546181
41FGFR11.17245057
42NTRK21.17140363
43MAP3K141.13494673
44PAK21.12141848
45ERBB41.10591236
46EPHB11.09408923
47STK38L1.08640197
48ERN11.07290405
49SCYL21.03465387
50CAMK1D1.02372753
51CAMK1G0.99686377
52PDGFRB0.99144978
53TGFBR10.99007677
54ERBB20.98932831
55CAMKK10.98543288
56DYRK1B0.97635204
57PAK40.96575145
58PRKD20.93476352
59BMX0.93301464
60MAPK150.92828795
61RET0.92193092
62NEK20.91447372
63FES0.91187994
64PIK3CA0.90315108
65BRD40.88697627
66FRK0.88528993
67RIPK40.87119218
68DYRK20.85419262
69ZAP700.85283840
70SMG10.85106735
71MKNK10.84897544
72CSNK1A1L0.81881960
73ALK0.80406345
74ICK0.79601473
75HIPK20.78945364
76MAP3K40.75621328
77BTK0.75520686
78BLK0.74906785
79RPS6KA40.74001200
80WNK10.73680372
81PAK60.73394465
82MELK0.73378357
83LMTK20.72965025
84SIK20.72787818
85MAPK120.72571106
86TYRO30.72369211
87RPS6KL10.71985855
88RPS6KC10.71985855
89LIMK10.71880334
90MAP2K10.70505537
91MAP3K20.68937564
92MAPK70.68915893
93FGFR20.68045429
94MAP2K40.67423278
95SIK30.67318404
96ROCK10.66925259
97RPS6KB20.66720820
98MAP3K80.63348617
99MAP3K90.61204771
100PLK20.60830473
101ILK0.60048084
102CAMK40.59335721
103TAOK10.59207408
104TTK0.58979694
105KSR20.58912880
106MAP2K30.58725296
107NTRK30.58482588
108CHUK0.57932504
109MAP3K10.56837714
110ACVR1B0.56408986
111CDC70.56135609
112PRKD30.55074087
113CSNK1D0.54662290
114FGR0.52960303
115CSK0.52459634
116TYK20.52007378
117RPS6KA60.52004307
118MAP3K50.51501977
119MARK20.51352333
120AKT20.49760390
121CSNK1G20.49139920
122FLT30.48867758
123RPS6KA20.47421425
124NLK0.47032970
125PDPK10.46682977
126MKNK20.46515089
127EPHA30.46105677
128MAP4K10.45835648
129CSNK1E0.45088087
130MST1R0.43913014
131CDK90.43905314
132SGK10.43708097
133HCK0.42784952
134PRKCZ0.42596210
135CHEK20.41301060
136RPS6KA10.41176654
137RPS6KB10.41092038
138ATM0.40953593
139CHEK10.40350731
140NTRK10.39912102
141STK380.39648213
142MAP3K70.39580854
143PRKCH0.38400918
144JAK10.38267157
145JAK20.38105212
146PLK30.38104691
147DYRK1A0.37953335
148CSNK1G10.37856415
149TESK10.37374002
150PRKDC0.37123103
151CDC42BPA0.36342371
152CDK20.35926126
153MAPK80.35056757
154CDK140.34367826
155MAPK100.32696246

Predicted pathways (KEGG)

RankGene SetZ-score
1Adherens junction_Homo sapiens_hsa045202.45075098
2Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.24651008
3Hippo signaling pathway_Homo sapiens_hsa043902.20443706
4ECM-receptor interaction_Homo sapiens_hsa045122.17084199
5Focal adhesion_Homo sapiens_hsa045102.09863135
6MicroRNAs in cancer_Homo sapiens_hsa052062.08030142
7Basal cell carcinoma_Homo sapiens_hsa052171.98588367
8Small cell lung cancer_Homo sapiens_hsa052221.94389876
9Proteoglycans in cancer_Homo sapiens_hsa052051.93611927
10Dilated cardiomyopathy_Homo sapiens_hsa054141.83320821
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.81021860
12Chronic myeloid leukemia_Homo sapiens_hsa052201.75944148
13TGF-beta signaling pathway_Homo sapiens_hsa043501.75664959
14Axon guidance_Homo sapiens_hsa043601.72520014
15Colorectal cancer_Homo sapiens_hsa052101.70782272
16Bladder cancer_Homo sapiens_hsa052191.69207809
17Hedgehog signaling pathway_Homo sapiens_hsa043401.66639232
18* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.66128556
19Endometrial cancer_Homo sapiens_hsa052131.63086573
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.60760833
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.57891662
22Tight junction_Homo sapiens_hsa045301.57268893
23Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.53819075
24Melanoma_Homo sapiens_hsa052181.51504605
25Glioma_Homo sapiens_hsa052141.50595442
26B cell receptor signaling pathway_Homo sapiens_hsa046621.47846353
27Other glycan degradation_Homo sapiens_hsa005111.46082948
28Viral myocarditis_Homo sapiens_hsa054161.43669695
29Wnt signaling pathway_Homo sapiens_hsa043101.40675737
30Amoebiasis_Homo sapiens_hsa051461.39126452
31mTOR signaling pathway_Homo sapiens_hsa041501.38472472
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.38254092
33Renal cell carcinoma_Homo sapiens_hsa052111.34690622
34Pancreatic cancer_Homo sapiens_hsa052121.34267340
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27365183
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.27072419
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.25917570
38Prostate cancer_Homo sapiens_hsa052151.25717873
39ErbB signaling pathway_Homo sapiens_hsa040121.22542037
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.20565280
41Lysine degradation_Homo sapiens_hsa003101.19903901
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.18209583
43Regulation of actin cytoskeleton_Homo sapiens_hsa048101.17587875
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13775921
45Osteoclast differentiation_Homo sapiens_hsa043801.09195250
46Long-term potentiation_Homo sapiens_hsa047201.09148458
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.08793094
48Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08684452
49Central carbon metabolism in cancer_Homo sapiens_hsa052301.08033212
50p53 signaling pathway_Homo sapiens_hsa041151.08010309
51Non-small cell lung cancer_Homo sapiens_hsa052231.06326439
52Cell cycle_Homo sapiens_hsa041101.04565271
53Pathways in cancer_Homo sapiens_hsa052001.04073259
54Inositol phosphate metabolism_Homo sapiens_hsa005620.99149391
55Melanogenesis_Homo sapiens_hsa049160.98434454
56Dorso-ventral axis formation_Homo sapiens_hsa043200.98237028
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.98136095
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98007677
59Hepatitis C_Homo sapiens_hsa051600.97905573
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.97826525
61PI3K-Akt signaling pathway_Homo sapiens_hsa041510.96456177
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96363547
63Estrogen signaling pathway_Homo sapiens_hsa049150.95654361
64Notch signaling pathway_Homo sapiens_hsa043300.94332758
65AMPK signaling pathway_Homo sapiens_hsa041520.92695079
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92053709
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91714054
68Gap junction_Homo sapiens_hsa045400.91599265
69T cell receptor signaling pathway_Homo sapiens_hsa046600.90643321
70FoxO signaling pathway_Homo sapiens_hsa040680.90492270
71Rap1 signaling pathway_Homo sapiens_hsa040150.89927195
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88665627
73Nitrogen metabolism_Homo sapiens_hsa009100.88397818
74Protein digestion and absorption_Homo sapiens_hsa049740.87672027
75VEGF signaling pathway_Homo sapiens_hsa043700.87140890
76Insulin signaling pathway_Homo sapiens_hsa049100.86415153
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84820214
78Insulin resistance_Homo sapiens_hsa049310.83496114
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83306157
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.81282662
81GnRH signaling pathway_Homo sapiens_hsa049120.81086071
82Cocaine addiction_Homo sapiens_hsa050300.80878078
83Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80522020
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80165960
85Viral carcinogenesis_Homo sapiens_hsa052030.79892148
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.79598131
87mRNA surveillance pathway_Homo sapiens_hsa030150.79555657
88Thyroid cancer_Homo sapiens_hsa052160.79051675
89Cholinergic synapse_Homo sapiens_hsa047250.78711016
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78103770
91HTLV-I infection_Homo sapiens_hsa051660.77935833
92Ovarian steroidogenesis_Homo sapiens_hsa049130.76984149
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76579758
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74879898
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74558821
96Type II diabetes mellitus_Homo sapiens_hsa049300.74204784
97Oocyte meiosis_Homo sapiens_hsa041140.73660805
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.73538435
99Prolactin signaling pathway_Homo sapiens_hsa049170.72025261
100Fatty acid biosynthesis_Homo sapiens_hsa000610.70808355
101Endocytosis_Homo sapiens_hsa041440.70527939
102Chemokine signaling pathway_Homo sapiens_hsa040620.70275179
103Long-term depression_Homo sapiens_hsa047300.69939655
104Influenza A_Homo sapiens_hsa051640.67898426
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66638724
106Prion diseases_Homo sapiens_hsa050200.66318986
107Platelet activation_Homo sapiens_hsa046110.65963594
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64554279
109Hepatitis B_Homo sapiens_hsa051610.62877545
110Ras signaling pathway_Homo sapiens_hsa040140.62513042
111Choline metabolism in cancer_Homo sapiens_hsa052310.62444373
112Glucagon signaling pathway_Homo sapiens_hsa049220.62110335
113Toxoplasmosis_Homo sapiens_hsa051450.62002211
114HIF-1 signaling pathway_Homo sapiens_hsa040660.61860157
115Oxytocin signaling pathway_Homo sapiens_hsa049210.61238733
116Leishmaniasis_Homo sapiens_hsa051400.60958309
117TNF signaling pathway_Homo sapiens_hsa046680.60344799
118NF-kappa B signaling pathway_Homo sapiens_hsa040640.58262576
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.57711357
120Tuberculosis_Homo sapiens_hsa051520.56548587
121MAPK signaling pathway_Homo sapiens_hsa040100.56086305
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53697956
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52051413
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51031815
125Shigellosis_Homo sapiens_hsa051310.48252962
126Apoptosis_Homo sapiens_hsa042100.46583256
127Alcoholism_Homo sapiens_hsa050340.45512985
128Systemic lupus erythematosus_Homo sapiens_hsa053220.44442909
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42563818
130Salmonella infection_Homo sapiens_hsa051320.41688535
131Acute myeloid leukemia_Homo sapiens_hsa052210.41229490
132RNA transport_Homo sapiens_hsa030130.40656817
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.39416863

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