PCGF6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)4.76754547
2DNA replication checkpoint (GO:0000076)4.50154660
3DNA deamination (GO:0045006)4.31473320
4DNA replication initiation (GO:0006270)4.29657002
5purine nucleobase biosynthetic process (GO:0009113)4.14330251
6mitotic nuclear envelope disassembly (GO:0007077)4.11608023
7protein localization to kinetochore (GO:0034501)4.08887292
8nucleobase biosynthetic process (GO:0046112)4.07816446
9nuclear pore organization (GO:0006999)4.06455800
10metaphase plate congression (GO:0051310)4.06437600
11nuclear pore complex assembly (GO:0051292)4.05740212
12DNA strand elongation involved in DNA replication (GO:0006271)4.05228523
13positive regulation of chromosome segregation (GO:0051984)3.96881042
14chromatin remodeling at centromere (GO:0031055)3.91604903
15DNA replication-dependent nucleosome organization (GO:0034723)3.88218847
16DNA replication-dependent nucleosome assembly (GO:0006335)3.88218847
17DNA strand elongation (GO:0022616)3.85723490
18protein localization to chromosome, centromeric region (GO:0071459)3.81266106
19membrane disassembly (GO:0030397)3.80353132
20nuclear envelope disassembly (GO:0051081)3.80353132
21CENP-A containing nucleosome assembly (GO:0034080)3.80191636
22formation of translation preinitiation complex (GO:0001731)3.79408592
23positive regulation of mitotic sister chromatid separation (GO:1901970)3.77959613
24positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.77959613
25positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.77959613
26ribosome biogenesis (GO:0042254)3.77694437
27maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.77018257
28proteasome assembly (GO:0043248)3.74837753
29telomere maintenance via semi-conservative replication (GO:0032201)3.73278719
30regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.71587532
31maturation of 5.8S rRNA (GO:0000460)3.70521029
32DNA replication-independent nucleosome organization (GO:0034724)3.70351237
33DNA replication-independent nucleosome assembly (GO:0006336)3.70351237
34mitotic sister chromatid segregation (GO:0000070)3.70227061
35DNA double-strand break processing (GO:0000729)3.67827864
36ribosome assembly (GO:0042255)3.67677082
37kinetochore organization (GO:0051383)3.67131245
38mitotic chromosome condensation (GO:0007076)3.65535309
39kinetochore assembly (GO:0051382)3.62926662
40regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.58531229
41DNA unwinding involved in DNA replication (GO:0006268)3.56509115
42regulation of spindle organization (GO:0090224)3.54795180
43regulation of centriole replication (GO:0046599)3.53719814
44histone exchange (GO:0043486)3.53187310
45regulation of sister chromatid cohesion (GO:0007063)3.52905259
46protein K6-linked ubiquitination (GO:0085020)3.52864083
47regulation of nuclear cell cycle DNA replication (GO:0033262)3.50880124
48maturation of SSU-rRNA (GO:0030490)3.49198907
49telomere maintenance via recombination (GO:0000722)3.47826450
50regulation of double-strand break repair via homologous recombination (GO:0010569)3.47701544
51establishment of chromosome localization (GO:0051303)3.47423391
52piRNA metabolic process (GO:0034587)3.45532264
53regulation of mitotic spindle checkpoint (GO:1903504)3.41679431
54regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.41679431
55attachment of spindle microtubules to kinetochore (GO:0008608)3.41189543
56replication fork processing (GO:0031297)3.39894364
57cullin deneddylation (GO:0010388)3.38275689
58mitochondrial RNA metabolic process (GO:0000959)3.36314569
59somatic hypermutation of immunoglobulin genes (GO:0016446)3.36139981
60somatic diversification of immune receptors via somatic mutation (GO:0002566)3.36139981
61regulation of chromosome segregation (GO:0051983)3.35490335
62negative regulation of DNA-dependent DNA replication (GO:2000104)3.33576326
63regulation of mitochondrial translation (GO:0070129)3.32628062
64rRNA modification (GO:0000154)3.32053979
65DNA catabolic process, exonucleolytic (GO:0000738)3.31522202
66mitotic recombination (GO:0006312)3.28190912
67meiotic chromosome segregation (GO:0045132)3.26527350
68double-strand break repair via nonhomologous end joining (GO:0006303)3.26034583
69non-recombinational repair (GO:0000726)3.26034583
70folic acid-containing compound biosynthetic process (GO:0009396)3.24103970
71sister chromatid segregation (GO:0000819)3.23827365
72negative regulation of chromosome segregation (GO:0051985)3.23431145
73protein deneddylation (GO:0000338)3.22132260
74spindle checkpoint (GO:0031577)3.20176657
75establishment of integrated proviral latency (GO:0075713)3.19658498
76postreplication repair (GO:0006301)3.18704025
77rRNA processing (GO:0006364)3.18126395
78regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.17727455
79protein localization to chromosome (GO:0034502)3.17657411
80telomere maintenance via telomere lengthening (GO:0010833)3.17541166
81regulation of DNA endoreduplication (GO:0032875)3.17450150
82chromatin assembly or disassembly (GO:0006333)3.16980703
83mitotic sister chromatid cohesion (GO:0007064)3.15922554
84regulation of mitotic metaphase/anaphase transition (GO:0030071)3.15785345
85ribonucleoprotein complex biogenesis (GO:0022613)3.15418166
86IMP biosynthetic process (GO:0006188)3.14302506
87regulation of centrosome cycle (GO:0046605)3.11846868
88negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.11089511
89rRNA metabolic process (GO:0016072)3.10951620
90negative regulation of sister chromatid segregation (GO:0033046)3.08357732
91negative regulation of mitotic sister chromatid separation (GO:2000816)3.08357732
92negative regulation of mitotic sister chromatid segregation (GO:0033048)3.08357732
93negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.08357732
94mitotic spindle checkpoint (GO:0071174)3.07388241
95regulation of sister chromatid segregation (GO:0033045)3.06744456
96regulation of mitotic sister chromatid separation (GO:0010965)3.06744456
97regulation of mitotic sister chromatid segregation (GO:0033047)3.06744456
98DNA ligation (GO:0006266)3.06708255
99regulation of RNA export from nucleus (GO:0046831)3.06195428
100translesion synthesis (GO:0019985)3.05627460
101histone H4-K12 acetylation (GO:0043983)3.05404862
102regulation of posttranscriptional gene silencing (GO:0060147)3.05299017
103regulation of gene silencing by miRNA (GO:0060964)3.05299017
104regulation of gene silencing by RNA (GO:0060966)3.05299017
105nucleotide-excision repair, DNA gap filling (GO:0006297)3.04797716
106synapsis (GO:0007129)3.04544635
107anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.04295053
108exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.03546747
109regulation of helicase activity (GO:0051095)3.02774769
110spliceosomal snRNP assembly (GO:0000387)3.02674353
111pore complex assembly (GO:0046931)3.02124054
112protein complex localization (GO:0031503)3.00882801
113termination of RNA polymerase II transcription (GO:0006369)3.00453063
114negative regulation of histone methylation (GO:0031061)3.00334020
115mitotic spindle assembly checkpoint (GO:0007094)3.00107203
116pre-miRNA processing (GO:0031054)2.99139129
117spindle assembly checkpoint (GO:0071173)2.98675229
118nuclear envelope organization (GO:0006998)2.97734705
119L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.97217303
120negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.96953662
121regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.96713364
122regulation of histone H3-K9 methylation (GO:0051570)2.96398678
123chromosome segregation (GO:0007059)2.95963591
124nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.95627977
125pseudouridine synthesis (GO:0001522)2.95341316
126RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.94076645
127tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.94076645
128DNA-dependent DNA replication (GO:0006261)2.92462348
129somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.89799894
130isotype switching (GO:0045190)2.89799894
131somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.89799894
132reciprocal meiotic recombination (GO:0007131)2.87359312
133reciprocal DNA recombination (GO:0035825)2.87359312
134DNA damage response, detection of DNA damage (GO:0042769)2.84854258
135transcription from mitochondrial promoter (GO:0006390)2.81859719
136telomere maintenance (GO:0000723)2.79965708
137positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.79549468
138recombinational repair (GO:0000725)2.79361818
139telomere organization (GO:0032200)2.78081528
140double-strand break repair via homologous recombination (GO:0000724)2.77134052
141base-excision repair (GO:0006284)2.76767604
142transcription-coupled nucleotide-excision repair (GO:0006283)2.76155562

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.59143114
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.43584499
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.14503668
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.77927337
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.36639607
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.21835344
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.07207557
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.99799790
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.95766466
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.86803771
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.81297324
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.64723391
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.58466834
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.57403131
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.48961696
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.48328029
17AR_21909140_ChIP-Seq_LNCAP_Human2.40049934
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34760948
19* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.32706032
20* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.31871457
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.22895214
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.22519171
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.15742501
24XRN2_22483619_ChIP-Seq_HELA_Human2.14619272
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.14246035
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.09770242
27SALL1_21062744_ChIP-ChIP_HESCs_Human2.09373141
28VDR_23849224_ChIP-Seq_CD4+_Human2.08816242
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.04963872
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.96772937
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.91716730
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91566318
33* GABP_19822575_ChIP-Seq_HepG2_Human1.90299801
34TTF2_22483619_ChIP-Seq_HELA_Human1.80373509
35SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.78980910
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76230542
37FOXP3_21729870_ChIP-Seq_TREG_Human1.76069435
38EWS_26573619_Chip-Seq_HEK293_Human1.72868322
39DCP1A_22483619_ChIP-Seq_HELA_Human1.70899111
40ZFX_18555785_ChIP-Seq_MESCs_Mouse1.65799081
41* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65176362
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64102308
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63549206
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.61802386
45KDM5A_27292631_Chip-Seq_BREAST_Human1.55376459
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55040171
47ZNF274_21170338_ChIP-Seq_K562_Hela1.54911221
48MYC_22102868_ChIP-Seq_BL_Human1.54108369
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.53748717
50CIITA_25753668_ChIP-Seq_RAJI_Human1.51308920
51* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.50643430
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47567061
53* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.46906982
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.43366110
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42747155
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.42106210
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.41562779
58KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.41414462
59KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.41414462
60KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.41414462
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39154825
62FUS_26573619_Chip-Seq_HEK293_Human1.39023992
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.37510490
64NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.37427724
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35034424
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31718880
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30729589
68IRF1_19129219_ChIP-ChIP_H3396_Human1.28614385
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25021150
70IGF1R_20145208_ChIP-Seq_DFB_Human1.21977687
71TCF3_18692474_ChIP-Seq_MESCs_Mouse1.20241047
72PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19700622
73VDR_22108803_ChIP-Seq_LS180_Human1.18873462
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18853181
75CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.18441545
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17973684
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.17701897
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17004894
79NANOG_21062744_ChIP-ChIP_HESCs_Human1.16187125
80NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13816334
81ELK1_19687146_ChIP-ChIP_HELA_Human1.13669313
82* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13184002
83TCF3_18692474_ChIP-Seq_MEFs_Mouse1.12959749
84POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12722908
85TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12564215
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10950407
87SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10357934
88CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10353865
89PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09196865
90MYC_18940864_ChIP-ChIP_HL60_Human1.07098200
91SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.05603723
92ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04952213
93* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03589361
94EGR1_19374776_ChIP-ChIP_THP-1_Human1.02899740
95NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.02313109
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01659656
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00257233
98SRF_21415370_ChIP-Seq_HL-1_Mouse0.98051232
99CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97226017
100ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96173981
101KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95258814
102KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92501130
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92150818
104POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91548139
105SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.91068068
106NANOG_16153702_ChIP-ChIP_HESCs_Human0.89873756
107ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89038340
108SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88970486
109* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.88362252
110ELF1_17652178_ChIP-ChIP_JURKAT_Human0.87694196
111ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.86495892
112SOX2_18692474_ChIP-Seq_MESCs_Mouse0.85809655
113TFEB_21752829_ChIP-Seq_HELA_Human0.85348986
114ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84788761
115SOX2_16153702_ChIP-ChIP_HESCs_Human0.84614886
116POU5F1_16518401_ChIP-PET_MESCs_Mouse0.83891167
117TP53_22573176_ChIP-Seq_HFKS_Human0.83341349
118NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.82630136
119SOX17_20123909_ChIP-Seq_XEN_Mouse0.79836729
120TAF15_26573619_Chip-Seq_HEK293_Human0.77525785
121FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.76843997
122GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75962804
123* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.75753962
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.72008061
125HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.70096962
126CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.69641155
127CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.69145180
128DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.69117496
129RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.69046737
130FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.67510611

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.24232631
2MP0008057_abnormal_DNA_replication5.21843764
3MP0010094_abnormal_chromosome_stability4.61302960
4MP0003111_abnormal_nucleus_morphology4.42360923
5MP0004957_abnormal_blastocyst_morpholog4.27520679
6MP0003077_abnormal_cell_cycle3.75476761
7MP0008877_abnormal_DNA_methylation3.45996062
8MP0008058_abnormal_DNA_repair3.25298144
9MP0003718_maternal_effect2.94142458
10MP0008007_abnormal_cellular_replicative2.85932645
11MP0009697_abnormal_copulation2.85683977
12MP0003123_paternal_imprinting2.72680468
13MP0008932_abnormal_embryonic_tissue2.54697291
14MP0002653_abnormal_ependyma_morphology2.44219256
15MP0001730_embryonic_growth_arrest2.42551303
16MP0000350_abnormal_cell_proliferation2.28446377
17MP0003786_premature_aging2.21701320
18MP0006292_abnormal_olfactory_placode2.08647370
19MP0002210_abnormal_sex_determination2.02810143
20MP0001672_abnormal_embryogenesis/_devel1.96580625
21MP0005380_embryogenesis_phenotype1.96580625
22MP0002234_abnormal_pharynx_morphology1.95339032
23MP0003890_abnormal_embryonic-extraembry1.95228616
24MP0001929_abnormal_gametogenesis1.90909443
25MP0001697_abnormal_embryo_size1.90394123
26MP0002085_abnormal_embryonic_tissue1.88797805
27MP0002084_abnormal_developmental_patter1.84672203
28MP0010307_abnormal_tumor_latency1.83622730
29MP0003121_genomic_imprinting1.77857769
30MP0001145_abnormal_male_reproductive1.75822472
31MP0010352_gastrointestinal_tract_polyps1.72305136
32MP0000653_abnormal_sex_gland1.69325998
33MP0003984_embryonic_growth_retardation1.64932909
34MP0002396_abnormal_hematopoietic_system1.62308960
35MP0002102_abnormal_ear_morphology1.61311660
36MP0002088_abnormal_embryonic_growth/wei1.59657253
37MP0004147_increased_porphyrin_level1.58530588
38MP0002080_prenatal_lethality1.55473876
39MP0006035_abnormal_mitochondrial_morpho1.53973055
40MP0002086_abnormal_extraembryonic_tissu1.51316519
41MP0006036_abnormal_mitochondrial_physio1.50184392
42MP0001293_anophthalmia1.47688308
43MP0003119_abnormal_digestive_system1.38142128
44MP0000490_abnormal_crypts_of1.36081829
45MP0005394_taste/olfaction_phenotype1.35126111
46MP0005499_abnormal_olfactory_system1.35126111
47MP0004197_abnormal_fetal_growth/weight/1.34232165
48MP0001119_abnormal_female_reproductive1.32270552
49MP0000313_abnormal_cell_death1.32068003
50MP0003186_abnormal_redox_activity1.31995966
51MP0004133_heterotaxia1.30913284
52MP0003698_abnormal_male_reproductive1.28615803
53MP0002160_abnormal_reproductive_system1.25548838
54MP0003806_abnormal_nucleotide_metabolis1.24739660
55MP0002019_abnormal_tumor_incidence1.21151687
56MP0003699_abnormal_female_reproductive1.20653705
57MP0003787_abnormal_imprinting1.19771893
58MP0005646_abnormal_pituitary_gland1.18424629
59MP0000372_irregular_coat_pigmentation1.17269564
60MP0003315_abnormal_perineum_morphology1.16723342
61MP0002163_abnormal_gland_morphology1.15214006
62MP0001188_hyperpigmentation1.14862460
63MP0010030_abnormal_orbit_morphology1.14384551
64MP0002161_abnormal_fertility/fecundity1.13753637
65MP0000427_abnormal_hair_cycle1.07279272
66MP0004264_abnormal_extraembryonic_tissu1.07231600
67MP0001764_abnormal_homeostasis1.07099318
68MP0003937_abnormal_limbs/digits/tail_de1.06142388
69MP0005397_hematopoietic_system_phenotyp1.05831661
70MP0001545_abnormal_hematopoietic_system1.05831661
71MP0000647_abnormal_sebaceous_gland1.05682927
72MP0003567_abnormal_fetal_cardiomyocyte1.05421915
73MP0005645_abnormal_hypothalamus_physiol1.03406722
74MP0002233_abnormal_nose_morphology1.02683015
75MP0000049_abnormal_middle_ear1.02186473
76MP0008995_early_reproductive_senescence0.96989680
77MP0005389_reproductive_system_phenotype0.96590390
78MP0003861_abnormal_nervous_system0.90477163
79MP0000631_abnormal_neuroendocrine_gland0.90136580
80MP0009333_abnormal_splenocyte_physiolog0.89721160
81MP0005395_other_phenotype0.87947339
82MP0005551_abnormal_eye_electrophysiolog0.86481301
83MP0001661_extended_life_span0.86261681
84MP0005253_abnormal_eye_physiology0.85797929
85MP0003646_muscle_fatigue0.84496566
86MP0001346_abnormal_lacrimal_gland0.83326707
87MP0002092_abnormal_eye_morphology0.81989585
88MP0005410_abnormal_fertilization0.80007473
89MP0002132_abnormal_respiratory_system0.78608479
90MP0004808_abnormal_hematopoietic_stem0.78321512
91MP0005391_vision/eye_phenotype0.77953200
92MP0009672_abnormal_birth_weight0.76742799
93MP0001286_abnormal_eye_development0.76599891
94MP0002111_abnormal_tail_morphology0.76528445
95MP0002095_abnormal_skin_pigmentation0.76057456
96MP0003941_abnormal_skin_development0.75398881
97MP0002751_abnormal_autonomic_nervous0.75146548
98MP0002697_abnormal_eye_size0.75021539
99MP0001984_abnormal_olfaction0.74099387
100MP0001529_abnormal_vocalization0.71860165
101MP0005076_abnormal_cell_differentiation0.70763956
102MP0000537_abnormal_urethra_morphology0.70404104
103MP0005384_cellular_phenotype0.70069805
104MP0002249_abnormal_larynx_morphology0.69776679
105MP0009703_decreased_birth_body0.69775719
106MP0005075_abnormal_melanosome_morpholog0.67923649
107MP0000703_abnormal_thymus_morphology0.67702739
108MP0002177_abnormal_outer_ear0.67336167
109MP0006072_abnormal_retinal_apoptosis0.66948314
110MP0002114_abnormal_axial_skeleton0.66912531
111MP0005266_abnormal_metabolism0.64596519
112MP0005621_abnormal_cell_physiology0.64558809
113MP0000432_abnormal_head_morphology0.63451957
114MP0002090_abnormal_vision0.62991001
115MP0003938_abnormal_ear_development0.62844851
116MP0000358_abnormal_cell_content/0.62213816
117MP0001919_abnormal_reproductive_system0.61615890
118MP0002009_preneoplasia0.60753550
119MP0003755_abnormal_palate_morphology0.60447102
120MP0003763_abnormal_thymus_physiology0.60122570
121MP0005367_renal/urinary_system_phenotyp0.59654942
122MP0000516_abnormal_urinary_system0.59654942
123MP0005647_abnormal_sex_gland0.57742522
124MP0003935_abnormal_craniofacial_develop0.57652956
125MP0002938_white_spotting0.57241851
126MP0003936_abnormal_reproductive_system0.57083419
127MP0000428_abnormal_craniofacial_morphol0.56905883
128MP0003221_abnormal_cardiomyocyte_apopto0.56830403
129MP0010234_abnormal_vibrissa_follicle0.55345191
130MP0001915_intracranial_hemorrhage0.54895319
131MP0008789_abnormal_olfactory_epithelium0.53617006
132MP0002127_abnormal_cardiovascular_syste0.53019278
133MP0002932_abnormal_joint_morphology0.51910868
134MP0001485_abnormal_pinna_reflex0.50445840

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.06377986
2Breast hypoplasia (HP:0003187)4.46635036
3Chromsome breakage (HP:0040012)3.94817764
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.90447939
5Facial hemangioma (HP:0000329)3.71517141
6Impulsivity (HP:0100710)3.69567385
7Patellar aplasia (HP:0006443)3.67631813
8Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.57495445
9Abnormality of alanine metabolism (HP:0010916)3.57495445
10Hyperalaninemia (HP:0003348)3.57495445
11Abnormality of the labia minora (HP:0012880)3.51169784
12Ependymoma (HP:0002888)3.43163913
13Aplasia/Hypoplasia of the patella (HP:0006498)3.40093484
14Degeneration of anterior horn cells (HP:0002398)3.40060237
15Abnormality of the anterior horn cell (HP:0006802)3.40060237
16Abnormality of the ileum (HP:0001549)3.23126379
17Absent radius (HP:0003974)3.21939434
18Supernumerary spleens (HP:0009799)3.15405956
19Medulloblastoma (HP:0002885)3.15216979
20Abnormality of the preputium (HP:0100587)3.13294649
21Abnormality of chromosome stability (HP:0003220)3.11308193
22Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.05592833
23Meckel diverticulum (HP:0002245)3.05102825
24Aplasia involving forearm bones (HP:0009822)3.04903015
25Absent forearm bone (HP:0003953)3.04903015
26Aplasia/Hypoplasia of the uvula (HP:0010293)3.02207314
27Absent thumb (HP:0009777)2.86072583
28Rhabdomyosarcoma (HP:0002859)2.85713261
29Colon cancer (HP:0003003)2.84985494
30Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.83047136
31Cerebral hypomyelination (HP:0006808)2.82735576
32Carpal bone hypoplasia (HP:0001498)2.82539958
33Oral leukoplakia (HP:0002745)2.78213121
34Volvulus (HP:0002580)2.72466023
35Selective tooth agenesis (HP:0001592)2.72223674
36Increased serum lactate (HP:0002151)2.70490592
37Abnormality of lateral ventricle (HP:0030047)2.65842483
38Myelodysplasia (HP:0002863)2.65830092
39Shawl scrotum (HP:0000049)2.62488501
40Increased hepatocellular lipid droplets (HP:0006565)2.61721576
41Rib fusion (HP:0000902)2.57838215
42Duodenal stenosis (HP:0100867)2.55454011
43Small intestinal stenosis (HP:0012848)2.55454011
44Premature ovarian failure (HP:0008209)2.55114853
45Neoplasm of the oral cavity (HP:0100649)2.54965328
46Ectopic kidney (HP:0000086)2.54387789
47Squamous cell carcinoma (HP:0002860)2.52613139
48Reticulocytopenia (HP:0001896)2.52422496
49Lipid accumulation in hepatocytes (HP:0006561)2.50267889
50Aplastic anemia (HP:0001915)2.48076101
51Increased CSF lactate (HP:0002490)2.47917550
52Abnormal spermatogenesis (HP:0008669)2.44509139
53Nephroblastoma (Wilms tumor) (HP:0002667)2.43449873
54Agnosia (HP:0010524)2.42944918
55Abnormality of the astrocytes (HP:0100707)2.42349597
56Astrocytoma (HP:0009592)2.42349597
57Horseshoe kidney (HP:0000085)2.40672494
58Basal cell carcinoma (HP:0002671)2.39578746
59Hypochromic microcytic anemia (HP:0004840)2.37850168
60Abnormality of cells of the erythroid lineage (HP:0012130)2.37697779
61Neoplasm of striated muscle (HP:0009728)2.36616207
62Acute encephalopathy (HP:0006846)2.35827410
63Aplasia/hypoplasia of the humerus (HP:0006507)2.34914624
64Sloping forehead (HP:0000340)2.34797978
65Abnormality of the duodenum (HP:0002246)2.29795473
66Capillary hemangiomas (HP:0005306)2.29140347
67Intestinal atresia (HP:0011100)2.28665627
68Abnormal number of erythroid precursors (HP:0012131)2.28525599
69Acute necrotizing encephalopathy (HP:0006965)2.28200348
70Short thumb (HP:0009778)2.27187203
71Lactic acidosis (HP:0003128)2.25205712
72Atrophy/Degeneration involving motor neurons (HP:0007373)2.24724723
73Embryonal renal neoplasm (HP:0011794)2.24433731
743-Methylglutaconic aciduria (HP:0003535)2.24277488
75Premature graying of hair (HP:0002216)2.24264460
76Abnormal mitochondria in muscle tissue (HP:0008316)2.23882036
77Microretrognathia (HP:0000308)2.23488177
78Pancreatic fibrosis (HP:0100732)2.23383949
79Rough bone trabeculation (HP:0100670)2.23289911
80Microvesicular hepatic steatosis (HP:0001414)2.23215247
81Overlapping toe (HP:0001845)2.22574086
82Oligodactyly (HP:0012165)2.20963077
83Pancreatic cysts (HP:0001737)2.17240313
84Clubbing of toes (HP:0100760)2.16183317
85Abnormality of serum amino acid levels (HP:0003112)2.15796344
86Increased serum pyruvate (HP:0003542)2.15184226
87Abnormality of the carotid arteries (HP:0005344)2.15144588
88Hyperglycinemia (HP:0002154)2.14760056
89Bone marrow hypocellularity (HP:0005528)2.14560786
90Secondary amenorrhea (HP:0000869)2.14252501
91Renal cortical cysts (HP:0000803)2.12474605
92Aplasia/Hypoplasia of the sternum (HP:0006714)2.12213382
93Poikiloderma (HP:0001029)2.11873786
94Prominent nose (HP:0000448)2.11110954
95Glioma (HP:0009733)2.10845546
96Short humerus (HP:0005792)2.10104951
97Abnormal protein glycosylation (HP:0012346)2.09173416
98Abnormal glycosylation (HP:0012345)2.09173416
99Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.09173416
100Abnormal protein N-linked glycosylation (HP:0012347)2.09173416
101Male infertility (HP:0003251)2.07449593
102Oligodactyly (hands) (HP:0001180)2.07121187
103Aplasia/Hypoplasia of the sacrum (HP:0008517)2.07026983
104Cafe-au-lait spot (HP:0000957)2.06618753
105Short tibia (HP:0005736)2.06308703
106Progressive muscle weakness (HP:0003323)2.05510008
107Neoplasm of the pancreas (HP:0002894)2.05218886
108Chronic bronchitis (HP:0004469)2.03055811
109Mitochondrial inheritance (HP:0001427)2.01632855
110Type I transferrin isoform profile (HP:0003642)2.01491488
111Cortical dysplasia (HP:0002539)2.00646559
112Tongue fasciculations (HP:0001308)2.00192248
113Decreased activity of mitochondrial respiratory chain (HP:0008972)2.00159215
114Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.00159215
115Abnormality of the pons (HP:0007361)1.98299602
116Triphalangeal thumb (HP:0001199)1.96955743
117Abnormality of midbrain morphology (HP:0002418)1.94501304
118Molar tooth sign on MRI (HP:0002419)1.94501304
119Sclerocornea (HP:0000647)1.94497255
120Hypoplasia of the pons (HP:0012110)1.94118985
121Abnormality of methionine metabolism (HP:0010901)1.93511177
122Atresia of the external auditory canal (HP:0000413)1.92765805
123Papillary thyroid carcinoma (HP:0002895)1.91320529
124Abnormality of DNA repair (HP:0003254)1.91136377
125Hypoplasia of the radius (HP:0002984)1.90946262
126Tracheoesophageal fistula (HP:0002575)1.89056532
127Breast aplasia (HP:0100783)1.88034072
128Cerebral edema (HP:0002181)1.88013687
129Aplasia/Hypoplasia of the tibia (HP:0005772)1.87120699
130Abnormal lung lobation (HP:0002101)1.86785270
131Abnormality of glycolysis (HP:0004366)1.86632209
132Abnormal number of incisors (HP:0011064)1.85699239
133Retinal dysplasia (HP:0007973)1.83567175
134Duplicated collecting system (HP:0000081)1.83537895
135Methylmalonic acidemia (HP:0002912)1.82986503
136Type 2 muscle fiber atrophy (HP:0003554)1.82715011
137Arteriovenous malformation (HP:0100026)1.82096719
138Preaxial hand polydactyly (HP:0001177)1.81978146
139Sparse lateral eyebrow (HP:0005338)1.81754824
140Aplasia/Hypoplasia of the breasts (HP:0010311)1.81014556
141Hepatocellular necrosis (HP:0001404)1.80768987
142Aplasia/hypoplasia of the uterus (HP:0008684)1.80376527
143Gonadotropin excess (HP:0000837)1.80080909
144Azoospermia (HP:0000027)1.79980591
145Broad alveolar ridges (HP:0000187)1.79405908
146Progressive macrocephaly (HP:0004481)1.79099606
147Spinal muscular atrophy (HP:0007269)1.78819286
148Muscle fiber atrophy (HP:0100295)1.78447355
149Facial cleft (HP:0002006)1.78097634
150Hepatic necrosis (HP:0002605)1.78027083
151Cellular immunodeficiency (HP:0005374)1.77861574
152Increased intramyocellular lipid droplets (HP:0012240)1.77750829
153Progressive microcephaly (HP:0000253)1.74788020
154Abnormality of the renal collecting system (HP:0004742)1.74459454
155Type II lissencephaly (HP:0007260)1.73830681
156Astigmatism (HP:0000483)1.73303916
157Aplasia/Hypoplasia of the tongue (HP:0010295)1.73257357
158Short middle phalanx of the 5th finger (HP:0004220)1.71535645
159Hypoplasia of the uterus (HP:0000013)1.68516746
160Methylmalonic aciduria (HP:0012120)1.68483704
161Neoplasm of the colon (HP:0100273)1.67882641
162Renal Fanconi syndrome (HP:0001994)1.67849702
163True hermaphroditism (HP:0010459)1.66722487

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.34731555
2WEE14.05116213
3BUB13.65486326
4NEK23.25871306
5MAP4K23.13054966
6MAP3K62.96897757
7TTK2.92768274
8TRIM282.71387376
9ACVR1B2.70974775
10PLK42.42078567
11PLK12.35003264
12BRSK22.34952174
13SRPK12.33703229
14EIF2AK12.23407328
15PBK2.22538076
16CHEK22.18883528
17DYRK32.17665211
18CDK122.08998008
19LATS22.02934714
20* CDK71.86290352
21VRK21.84889947
22MKNK21.82106679
23NUAK11.76171023
24BCKDK1.68736112
25STK38L1.68638501
26MST41.68092991
27ATR1.67249028
28NEK11.67138109
29PLK31.66015585
30MKNK11.64700220
31BCR1.62470632
32AURKB1.61668777
33LATS11.53606558
34VRK11.48988470
35ERBB31.48980546
36RPS6KB21.47355673
37CHEK11.38402831
38AURKA1.36404378
39CDK41.34973691
40EEF2K1.32298862
41STK161.30268830
42EIF2AK31.29560699
43TSSK61.26616043
44PASK1.24122860
45TAF11.24052175
46ICK1.21914459
47BMPR1B1.20511276
48PDK21.18685237
49CDK81.18645942
50CDK191.16966962
51BRSK11.15282628
52RAF11.11314904
53ATM1.08547095
54CSNK1A1L1.07117175
55EPHA21.06546279
56MAP3K81.05405709
57BRAF1.04994385
58CDK21.04703651
59AKT30.99028432
60CSNK1G20.97843751
61MAP3K100.95982993
62STK30.95976325
63MELK0.93835037
64MAP2K70.93257741
65STK100.89297050
66EIF2AK20.89031746
67DYRK20.88815954
68PDK30.86446246
69PDK40.86446246
70PIM20.83463789
71ERBB40.82930536
72SIK30.81064159
73ARAF0.81030590
74PIM10.80718281
75TYRO30.80543412
76RPS6KA50.78719284
77NME10.77739922
78CDK10.77560885
79PNCK0.75686569
80MAPKAPK30.72772357
81RPS6KA40.71086594
82KDR0.70200268
83TLK10.69642846
84SCYL20.66616478
85PLK20.66295292
86KSR10.65713139
87PINK10.65239939
88WNK40.64979504
89CDK60.64608140
90BRD40.64551004
91PRKCI0.63859610
92STK40.63652621
93CCNB10.63567867
94TGFBR10.61288298
95CSNK2A20.61103183
96CSNK1E0.60645076
97TESK20.59768729
98TAOK30.59593403
99DAPK10.58388380
100MAPK130.56253702
101CSNK2A10.51968622
102NME20.50663058
103INSRR0.50657535
104CLK10.50128264
105OXSR10.49669641
106STK390.49498448
107MAPK150.49089328
108KSR20.48580505
109MAPK110.47089033
110ADRBK20.46761190
111PAK10.45591492
112MTOR0.43959542
113ALK0.43357968
114MAP3K50.42834958
115CSNK1G10.42635679
116LIMK10.42533291
117TNIK0.42322256
118FRK0.41177198
119MAP3K40.41142195
120STK240.39566847
121ABL20.39113147
122MAP3K90.38137658
123MAPK140.37839207
124CDK140.37336996
125ZAK0.36716900
126CDK90.35053096
127CASK0.34038493
128GSK3B0.33080566
129MOS0.32520126
130CSNK1G30.32340531
131PRKDC0.32328241
132TAOK10.31081171
133YES10.30973640
134WNK30.30189491
135CDK30.28422926
136RPS6KB10.27447064
137STK380.27399601

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.64957101
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.37992602
3Mismatch repair_Homo sapiens_hsa034304.35917668
4RNA transport_Homo sapiens_hsa030133.68876300
5RNA polymerase_Homo sapiens_hsa030203.33231114
6Spliceosome_Homo sapiens_hsa030403.28788067
7Cell cycle_Homo sapiens_hsa041103.22885339
8Base excision repair_Homo sapiens_hsa034103.16372559
9Homologous recombination_Homo sapiens_hsa034403.06764810
10Nucleotide excision repair_Homo sapiens_hsa034202.94452019
11Fanconi anemia pathway_Homo sapiens_hsa034602.75375317
12Basal transcription factors_Homo sapiens_hsa030222.69544939
13RNA degradation_Homo sapiens_hsa030182.41009830
14Pyrimidine metabolism_Homo sapiens_hsa002402.40873809
15One carbon pool by folate_Homo sapiens_hsa006702.31703628
16Ribosome_Homo sapiens_hsa030102.30496320
17mRNA surveillance pathway_Homo sapiens_hsa030152.29044681
18Vitamin B6 metabolism_Homo sapiens_hsa007502.14258884
19Protein export_Homo sapiens_hsa030602.10941036
20p53 signaling pathway_Homo sapiens_hsa041151.94968571
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.94421993
22Proteasome_Homo sapiens_hsa030501.90921717
23Non-homologous end-joining_Homo sapiens_hsa034501.82362979
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.75008981
25Oocyte meiosis_Homo sapiens_hsa041141.60413118
26Oxidative phosphorylation_Homo sapiens_hsa001901.51225870
27Parkinsons disease_Homo sapiens_hsa050121.49669283
28Propanoate metabolism_Homo sapiens_hsa006401.45230973
29Purine metabolism_Homo sapiens_hsa002301.43598538
30Fatty acid elongation_Homo sapiens_hsa000621.41530871
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.32231770
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32146572
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.29505208
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.28632125
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17823050
36Pyruvate metabolism_Homo sapiens_hsa006201.17697819
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11087733
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06975809
39Steroid biosynthesis_Homo sapiens_hsa001000.97654451
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.96514991
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95409599
42Folate biosynthesis_Homo sapiens_hsa007900.92762925
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92249853
44Systemic lupus erythematosus_Homo sapiens_hsa053220.91966884
45Selenocompound metabolism_Homo sapiens_hsa004500.91148217
46Thyroid cancer_Homo sapiens_hsa052160.89600009
47Epstein-Barr virus infection_Homo sapiens_hsa051690.89143161
48Biosynthesis of amino acids_Homo sapiens_hsa012300.87788355
49Cyanoamino acid metabolism_Homo sapiens_hsa004600.87313037
50MicroRNAs in cancer_Homo sapiens_hsa052060.85861354
51Viral carcinogenesis_Homo sapiens_hsa052030.78265013
52Herpes simplex infection_Homo sapiens_hsa051680.75909527
53Sulfur metabolism_Homo sapiens_hsa009200.75608921
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.74702812
55TGF-beta signaling pathway_Homo sapiens_hsa043500.71792071
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68323171
57Colorectal cancer_Homo sapiens_hsa052100.67416041
58Circadian rhythm_Homo sapiens_hsa047100.67319209
59Pentose phosphate pathway_Homo sapiens_hsa000300.66114251
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65948517
61Alzheimers disease_Homo sapiens_hsa050100.65186562
62Sulfur relay system_Homo sapiens_hsa041220.64918971
63* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63814897
64Hippo signaling pathway_Homo sapiens_hsa043900.62521003
65Butanoate metabolism_Homo sapiens_hsa006500.61036039
66mTOR signaling pathway_Homo sapiens_hsa041500.58585028
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58204005
68HTLV-I infection_Homo sapiens_hsa051660.57174446
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55470521
70Phototransduction_Homo sapiens_hsa047440.55218701
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50561096
72Notch signaling pathway_Homo sapiens_hsa043300.50497458
73Fatty acid metabolism_Homo sapiens_hsa012120.47399819
74Basal cell carcinoma_Homo sapiens_hsa052170.44614496
75Peroxisome_Homo sapiens_hsa041460.43791867
76Alcoholism_Homo sapiens_hsa050340.43636532
77Hedgehog signaling pathway_Homo sapiens_hsa043400.43211251
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42281632
79Antigen processing and presentation_Homo sapiens_hsa046120.42073322
80Small cell lung cancer_Homo sapiens_hsa052220.41344531
81Bladder cancer_Homo sapiens_hsa052190.40677597
82Wnt signaling pathway_Homo sapiens_hsa043100.39634988
83Linoleic acid metabolism_Homo sapiens_hsa005910.39005141
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38734124
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34438206
86Glutathione metabolism_Homo sapiens_hsa004800.33906125
87Nitrogen metabolism_Homo sapiens_hsa009100.31670485
88Olfactory transduction_Homo sapiens_hsa047400.30529775
89Arginine and proline metabolism_Homo sapiens_hsa003300.29266676
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28320098
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27466923
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26547937
93N-Glycan biosynthesis_Homo sapiens_hsa005100.26301626
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.25473302
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24901565
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24791371
97Lysine degradation_Homo sapiens_hsa003100.24586959
98Prostate cancer_Homo sapiens_hsa052150.24584225
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24127688
100Endometrial cancer_Homo sapiens_hsa052130.23772732
101Tryptophan metabolism_Homo sapiens_hsa003800.23504569
102Pancreatic cancer_Homo sapiens_hsa052120.23331681
103Dorso-ventral axis formation_Homo sapiens_hsa043200.22004824
104Adherens junction_Homo sapiens_hsa045200.20133734
105Cardiac muscle contraction_Homo sapiens_hsa042600.19069721
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18649956
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.18349265
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.18338727
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.18138796
110Choline metabolism in cancer_Homo sapiens_hsa052310.18101255
111Pathways in cancer_Homo sapiens_hsa052000.17787931
112Hepatitis B_Homo sapiens_hsa051610.16909678
113Regulation of autophagy_Homo sapiens_hsa041400.16474824
114Metabolic pathways_Homo sapiens_hsa011000.16306784
115FoxO signaling pathway_Homo sapiens_hsa040680.15985756
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.15794828
117Non-small cell lung cancer_Homo sapiens_hsa052230.15644323
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.14997044
119Caffeine metabolism_Homo sapiens_hsa002320.13301747
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.13174755
121Fatty acid biosynthesis_Homo sapiens_hsa000610.12139896
122Nicotine addiction_Homo sapiens_hsa050330.12080294
123Fructose and mannose metabolism_Homo sapiens_hsa000510.12068557
124Fatty acid degradation_Homo sapiens_hsa000710.11925554
125Huntingtons disease_Homo sapiens_hsa050160.11619118
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.11482358
127Shigellosis_Homo sapiens_hsa051310.11408792
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10592891
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.09637962
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.09323892
131Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.09053659
132Chronic myeloid leukemia_Homo sapiens_hsa052200.08974097
133Carbon metabolism_Homo sapiens_hsa012000.08411792
134Arginine biosynthesis_Homo sapiens_hsa002200.08116267
135Melanoma_Homo sapiens_hsa052180.07627243
136Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.06969373
137Acute myeloid leukemia_Homo sapiens_hsa052210.06420569
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.05131190

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