ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	7.71459489
2	proteasome assembly (GO:0043248)	7.09085285
3	acrosome reaction (GO:0007340)	5.98843493
4	fusion of sperm to egg plasma membrane (GO:0007342)	5.93823926
5	sperm motility (GO:0030317)	5.68782578
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.59416083
7	chromosome condensation (GO:0030261)	5.44955637
8	single strand break repair (GO:0000012)	4.99943461
9	spermatid nucleus differentiation (GO:0007289)	4.88330255
10	DNA damage response, detection of DNA damage (GO:0042769)	4.81722486
11	DNA packaging (GO:0006323)	4.80521069
12	ATP synthesis coupled proton transport (GO:0015986)	4.68708633
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.68708633
14	microtubule depolymerization (GO:0007019)	4.65182948
15	microtubule severing (GO:0051013)	4.53556609
16	plasma membrane fusion (GO:0045026)	4.49880946
17	histone exchange (GO:0043486)	4.46624256
18	protein polyglutamylation (GO:0018095)	4.46196221
19	spermatid development (GO:0007286)	4.29879821
20	DNA double-strand break processing (GO:0000729)	4.11117507
21	sperm-egg recognition (GO:0035036)	4.05796154
22	rRNA modification (GO:0000154)	4.05687526
23	rRNA methylation (GO:0031167)	4.04370308
24	chromatin remodeling at centromere (GO:0031055)	4.02984420
25	sperm capacitation (GO:0048240)	3.88460279
26	CENP-A containing nucleosome assembly (GO:0034080)	3.85568342
27	multicellular organism reproduction (GO:0032504)	3.84896509
28	L-fucose catabolic process (GO:0042355)	3.84597142
29	fucose catabolic process (GO:0019317)	3.84597142
30	L-fucose metabolic process (GO:0042354)	3.84597142
31	protein K6-linked ubiquitination (GO:0085020)	3.82325237
32	microtubule polymerization or depolymerization (GO:0031109)	3.81710452
33	behavioral response to nicotine (GO:0035095)	3.81628945
34	positive regulation of guanylate cyclase activity (GO:0031284)	3.77345452
35	maturation of SSU-rRNA (GO:0030490)	3.77222356
36	binding of sperm to zona pellucida (GO:0007339)	3.74182667
37	positive regulation of gastrulation (GO:2000543)	3.58763655
38	mitotic G2 DNA damage checkpoint (GO:0007095)	3.57231054
39	regulation of centriole replication (GO:0046599)	3.55728316
40	protein neddylation (GO:0045116)	3.52244367
41	mitotic G2/M transition checkpoint (GO:0044818)	3.44279574
42	cellular ketone body metabolic process (GO:0046950)	3.44260331
43	centriole replication (GO:0007099)	3.42281563
44	kinetochore assembly (GO:0051382)	3.39664038
45	regulation of guanylate cyclase activity (GO:0031282)	3.37251289
46	protein complex biogenesis (GO:0070271)	3.32576898
47	respiratory electron transport chain (GO:0022904)	3.28761687
48	male gamete generation (GO:0048232)	3.26526680
49	cell-cell recognition (GO:0009988)	3.26248022
50	kinetochore organization (GO:0051383)	3.25707672
51	spermatogenesis (GO:0007283)	3.24794189
52	reproduction (GO:0000003)	3.24541242
53	DNA replication checkpoint (GO:0000076)	3.23645215
54	mitochondrial respiratory chain complex assembly (GO:0033108)	3.21984294
55	calcium ion-dependent exocytosis (GO:0017156)	3.20694257
56	electron transport chain (GO:0022900)	3.20074525
57	regulation of mitochondrial translation (GO:0070129)	3.16421935
58	regulation of cilium movement (GO:0003352)	3.14149474
59	viral transcription (GO:0019083)	3.09741482
60	translational termination (GO:0006415)	3.09279727
61	ketone body metabolic process (GO:1902224)	3.06091016
62	gamete generation (GO:0007276)	3.04204355
63	platelet dense granule organization (GO:0060155)	2.99290027
64	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.99007368
65	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.99007368
66	NADH dehydrogenase complex assembly (GO:0010257)	2.99007368
67	telomere maintenance via semi-conservative replication (GO:0032201)	2.98637496
68	regulation of DNA endoreduplication (GO:0032875)	2.98511522
69	oxidative phosphorylation (GO:0006119)	2.97872290
70	regulation of mesoderm development (GO:2000380)	2.97350901
71	axonemal dynein complex assembly (GO:0070286)	2.95167818
72	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.94701434
73	water-soluble vitamin biosynthetic process (GO:0042364)	2.92822042
74	regulation of transcription involved in cell fate commitment (GO:0060850)	2.88108948
75	replication fork processing (GO:0031297)	2.85059051
76	regulation of telomere maintenance via telomerase (GO:0032210)	2.83202406
77	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.82744907
78	ATP biosynthetic process (GO:0006754)	2.81693876
79	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.80277216
80	glycerol ether metabolic process (GO:0006662)	2.79352605
81	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.76131357
82	coenzyme catabolic process (GO:0009109)	2.70959825
83	negative regulation of telomerase activity (GO:0051974)	2.70606505
84	tongue development (GO:0043586)	2.66844850
85	single fertilization (GO:0007338)	2.65726071
86	centriole assembly (GO:0098534)	2.65613766
87	positive regulation of endothelial cell differentiation (GO:0045603)	2.63687984
88	DNA replication-independent nucleosome assembly (GO:0006336)	2.63654309
89	DNA replication-independent nucleosome organization (GO:0034724)	2.63654309
90	NAD biosynthetic process (GO:0009435)	2.63337784
91	chromatin silencing (GO:0006342)	2.62040910
92	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.61065014
93	ether metabolic process (GO:0018904)	2.59963904
94	negative regulation of telomere maintenance (GO:0032205)	2.58623897
95	GTP biosynthetic process (GO:0006183)	2.58516712
96	sulfation (GO:0051923)	2.57156010
97	ribosomal small subunit assembly (GO:0000028)	2.56356875
98	cellular protein complex disassembly (GO:0043624)	2.54536928
99	negative regulation of B cell apoptotic process (GO:0002903)	2.53893702
100	epithelial cilium movement (GO:0003351)	2.53200355

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.94655757
2	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	3.72375524
3	VDR_22108803_ChIP-Seq_LS180_Human	3.61332565
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.05592221
5	FUS_26573619_Chip-Seq_HEK293_Human	2.92609677
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.81007071
7	E2F7_22180533_ChIP-Seq_HELA_Human	2.79854470
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.69712642
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.64383349
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.55993798
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.45751273
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.41693783
13	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.28136186
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.21898275
15	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.15445467
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.05824219
17	MYC_18940864_ChIP-ChIP_HL60_Human	2.00194915
18	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.97695072
19	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.94182742
20	IGF1R_20145208_ChIP-Seq_DFB_Human	1.88412588
21	EZH2_22144423_ChIP-Seq_EOC_Human	1.87972443
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.84562241
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.83372431
24	P300_19829295_ChIP-Seq_ESCs_Human	1.74759116
25	EWS_26573619_Chip-Seq_HEK293_Human	1.68244215
26	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.68225003
27	ERA_21632823_ChIP-Seq_H3396_Human	1.64162296
28	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.57733676
29	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.56683778
30	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.56683778
31	ER_23166858_ChIP-Seq_MCF-7_Human	1.51497212
32	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.49696996
33	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.49420325
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.49242850
35	NANOG_20526341_ChIP-Seq_ESCs_Human	1.49092560
36	TAF2_19829295_ChIP-Seq_ESCs_Human	1.43956413
37	ELK1_19687146_ChIP-ChIP_HELA_Human	1.43864806
38	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.40353262
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.38754094
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.38754094
41	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.37610249
42	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.33597919
43	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.33129919
44	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.32389829
45	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.31799236
46	MYC_19829295_ChIP-Seq_ESCs_Human	1.30442132
47	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.25265155
48	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.22990109
49	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.22682739
50	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.22173744
51	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.20788479
52	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.20646917
53	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.20415606
54	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.19769490
55	TP53_22573176_ChIP-Seq_HFKS_Human	1.19345557
56	FOXP3_21729870_ChIP-Seq_TREG_Human	1.18688357
57	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.18524722
58	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.18117707
59	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.17031874
60	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.12693633
61	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.12443669
62	HOXB7_26014856_ChIP-Seq_BT474_Human	1.11791244
63	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.11636905
64	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.11476815
65	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.11080706
66	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.09609474
67	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.09298712
68	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.08564071
69	AR_25329375_ChIP-Seq_VCAP_Human	1.08193606
70	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.07347672
71	NANOG_19829295_ChIP-Seq_ESCs_Human	1.07143220
72	SOX2_19829295_ChIP-Seq_ESCs_Human	1.07143220
73	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.05605904
74	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.05524912
75	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.04886800
76	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.04430700
77	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.04025659
78	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.03413674
79	TTF2_22483619_ChIP-Seq_HELA_Human	1.03117236
80	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.03075206
81	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.02516417
82	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.02516417
83	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.02378954
84	NCOR_22424771_ChIP-Seq_293T_Human	1.00640588
85	GBX2_23144817_ChIP-Seq_PC3_Human	0.99717174
86	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.99698471
87	NFYB_21822215_ChIP-Seq_K562_Human	0.99324439
88	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.98867114
89	ETV1_20927104_ChIP-Seq_GIST48_Human	0.98140803
90	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.96640797
91	ERG_20517297_ChIP-Seq_VCAP_Human	0.95294077
92	TP53_18474530_ChIP-ChIP_U2OS_Human	0.94903753
93	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.94620596
94	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.94192452
95	RBPJ_21746931_ChIP-Seq_IB4_Human	0.93991824
96	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.93966849
97	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.93668623
98	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.93566291
99	PHF8_20622853_ChIP-Seq_HELA_Human	0.92676363
100	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.91182670

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	5.72721038
2	MP0005410_abnormal_fertilization	5.09244481
3	MP0003136_yellow_coat_color	3.29939335
4	MP0002234_abnormal_pharynx_morphology	3.03793040
5	MP0003693_abnormal_embryo_hatching	2.68572371
6	MP0002736_abnormal_nociception_after	2.51981934
7	MP0001968_abnormal_touch/_nociception	2.50582958
8	MP0003698_abnormal_male_reproductive	2.36059230
9	MP0003718_maternal_effect	2.13422188
10	MP0003011_delayed_dark_adaptation	2.04536812
11	MP0000566_synostosis	2.03413736
12	MP0001929_abnormal_gametogenesis	2.00318763
13	MP0008789_abnormal_olfactory_epithelium	1.94162099
14	MP0002735_abnormal_chemical_nociception	1.92901878
15	MP0009379_abnormal_foot_pigmentation	1.92775446
16	MP0003878_abnormal_ear_physiology	1.91975467
17	MP0005377_hearing/vestibular/ear_phenot	1.91975467
18	MP0001984_abnormal_olfaction	1.91830931
19	MP0009053_abnormal_anal_canal	1.84167819
20	MP0008058_abnormal_DNA_repair	1.82395771
21	MP0010094_abnormal_chromosome_stability	1.82102707
22	MP0002938_white_spotting	1.81446003
23	MP0001293_anophthalmia	1.77844854
24	MP0002822_catalepsy	1.77362272
25	MP0005551_abnormal_eye_electrophysiolog	1.75370235
26	MP0000678_abnormal_parathyroid_gland	1.62268171
27	MP0003283_abnormal_digestive_organ	1.58329524
28	MP0004885_abnormal_endolymph	1.57873203
29	MP0005499_abnormal_olfactory_system	1.57443322
30	MP0005394_taste/olfaction_phenotype	1.57443322
31	MP0000049_abnormal_middle_ear	1.56812246
32	MP0003646_muscle_fatigue	1.55672432
33	MP0003195_calcinosis	1.54286410
34	MP0002254_reproductive_system_inflammat	1.47447956
35	MP0010386_abnormal_urinary_bladder	1.46708527
36	MP0002249_abnormal_larynx_morphology	1.45149357
37	MP0003880_abnormal_central_pattern	1.41661912
38	MP0001485_abnormal_pinna_reflex	1.38232927
39	MP0000631_abnormal_neuroendocrine_gland	1.36433538
40	MP0002837_dystrophic_cardiac_calcinosis	1.36074011
41	MP0002733_abnormal_thermal_nociception	1.35089247
42	MP0002161_abnormal_fertility/fecundity	1.28973351
43	MP0005379_endocrine/exocrine_gland_phen	1.28533143
44	MP0002160_abnormal_reproductive_system	1.28349874
45	MP0004133_heterotaxia	1.26857435
46	MP0002277_abnormal_respiratory_mucosa	1.26450622
47	MP0006072_abnormal_retinal_apoptosis	1.23560656
48	MP0003786_premature_aging	1.22143762
49	MP0002734_abnormal_mechanical_nocicepti	1.21277385
50	MP0002210_abnormal_sex_determination	1.19503321
51	MP0001764_abnormal_homeostasis	1.15807920
52	MP0005253_abnormal_eye_physiology	1.15399863
53	MP0004043_abnormal_pH_regulation	1.15256300
54	MP0004142_abnormal_muscle_tone	1.11683055
55	MP0001145_abnormal_male_reproductive	1.11321790
56	MP0000653_abnormal_sex_gland	1.10639169
57	MP0003938_abnormal_ear_development	1.10085471
58	MP0003077_abnormal_cell_cycle	1.09981600
59	MP0005389_reproductive_system_phenotype	1.08878913
60	MP0003111_abnormal_nucleus_morphology	1.06334834
61	MP0001529_abnormal_vocalization	1.05947811
62	MP0000372_irregular_coat_pigmentation	1.04953770
63	MP0009745_abnormal_behavioral_response	1.03784150
64	MP0004957_abnormal_blastocyst_morpholog	1.03065543
65	MP0002282_abnormal_trachea_morphology	1.02311151
66	MP0003890_abnormal_embryonic-extraembry	1.01930309
67	MP0008775_abnormal_heart_ventricle	1.01868000
68	MP0005084_abnormal_gallbladder_morpholo	1.00843538
69	MP0008877_abnormal_DNA_methylation	0.99920063
70	MP0002272_abnormal_nervous_system	0.98834919
71	MP0005423_abnormal_somatic_nervous	0.98462090
72	MP0003567_abnormal_fetal_cardiomyocyte	0.97299306
73	MP0003119_abnormal_digestive_system	0.97206239
74	MP0000026_abnormal_inner_ear	0.96671067
75	MP0005645_abnormal_hypothalamus_physiol	0.93781689
76	MP0002127_abnormal_cardiovascular_syste	0.91907756
77	MP0001970_abnormal_pain_threshold	0.90138199
78	MP0004510_myositis	0.89405204
79	MP0005248_abnormal_Harderian_gland	0.88304170
80	MP0001879_abnormal_lymphatic_vessel	0.87541714
81	MP0002572_abnormal_emotion/affect_behav	0.84591586
82	MP0009697_abnormal_copulation	0.84398724
83	MP0001986_abnormal_taste_sensitivity	0.83874732
84	MP0002067_abnormal_sensory_capabilities	0.82254862
85	MP0001286_abnormal_eye_development	0.80481593
86	MP0002102_abnormal_ear_morphology	0.80300635
87	MP0001963_abnormal_hearing_physiology	0.78604807
88	MP0000427_abnormal_hair_cycle	0.77905189
89	MP0009046_muscle_twitch	0.75852124
90	MP0005391_vision/eye_phenotype	0.74273207
91	MP0000639_abnormal_adrenal_gland	0.73779629
92	MP0003755_abnormal_palate_morphology	0.73564264
93	MP0005195_abnormal_posterior_eye	0.73424131
94	MP0002697_abnormal_eye_size	0.73017064
95	MP0005670_abnormal_white_adipose	0.69399874
96	MP0002751_abnormal_autonomic_nervous	0.69148020
97	MP0008932_abnormal_embryonic_tissue	0.66495182
98	MP0000569_abnormal_digit_pigmentation	0.65954072
99	MP0001486_abnormal_startle_reflex	0.65142886
100	MP0004742_abnormal_vestibular_system	0.65050788

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chronic hepatic failure (HP:0100626)	5.12016545
2	Severe visual impairment (HP:0001141)	4.88790140
3	Septo-optic dysplasia (HP:0100842)	4.47335814
4	Nephronophthisis (HP:0000090)	3.45416347
5	Absent/shortened dynein arms (HP:0200106)	3.40150482
6	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.40150482
7	Bony spicule pigmentary retinopathy (HP:0007737)	3.19790760
8	Abnormality of macular pigmentation (HP:0008002)	3.16779725
9	Renal Fanconi syndrome (HP:0001994)	3.05370362
10	Generalized aminoaciduria (HP:0002909)	2.99752730
11	Optic nerve hypoplasia (HP:0000609)	2.92428386
12	Azoospermia (HP:0000027)	2.86384476
13	Attenuation of retinal blood vessels (HP:0007843)	2.84470068
14	Pancreatic cysts (HP:0001737)	2.81962289
15	Renal cortical cysts (HP:0000803)	2.80852453
16	Abnormality of the renal medulla (HP:0100957)	2.79568100
17	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.78314950
18	Aplastic anemia (HP:0001915)	2.75316931
19	Increased hepatocellular lipid droplets (HP:0006565)	2.72064965
20	Molar tooth sign on MRI (HP:0002419)	2.71092774
21	Abnormality of midbrain morphology (HP:0002418)	2.71092774
22	Abnormality of the renal cortex (HP:0011035)	2.68601130
23	Abnormality of renal resorption (HP:0011038)	2.68127186
24	Congenital stationary night blindness (HP:0007642)	2.57824084
25	Acute necrotizing encephalopathy (HP:0006965)	2.52996239
26	Sclerocornea (HP:0000647)	2.51685661
27	Acute encephalopathy (HP:0006846)	2.50721333
28	Lipid accumulation in hepatocytes (HP:0006561)	2.50037255
29	Absent septum pellucidum (HP:0001331)	2.49199954
30	Confusion (HP:0001289)	2.47373036
31	Pancreatic fibrosis (HP:0100732)	2.46675525
32	3-Methylglutaconic aciduria (HP:0003535)	2.43471025
33	Maternal diabetes (HP:0009800)	2.43290930
34	Medial flaring of the eyebrow (HP:0010747)	2.41867643
35	True hermaphroditism (HP:0010459)	2.41668482
36	Abnormal spermatogenesis (HP:0008669)	2.38643633
37	Mitochondrial inheritance (HP:0001427)	2.37293039
38	Abnormality of alanine metabolism (HP:0010916)	2.35090822
39	Hyperalaninemia (HP:0003348)	2.35090822
40	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.35090822
41	Abnormality of urine glucose concentration (HP:0011016)	2.33044641
42	Glycosuria (HP:0003076)	2.33044641
43	Esophageal atresia (HP:0002032)	2.31400208
44	Abnormal rod and cone electroretinograms (HP:0008323)	2.30065190
45	Hepatocellular necrosis (HP:0001404)	2.27911943
46	Pendular nystagmus (HP:0012043)	2.24942954
47	Abnormal mitochondria in muscle tissue (HP:0008316)	2.24294656
48	Abnormal ciliary motility (HP:0012262)	2.24173823
49	Hepatic necrosis (HP:0002605)	2.18264606
50	Volvulus (HP:0002580)	2.15768124
51	Decreased central vision (HP:0007663)	2.13927485
52	Exertional dyspnea (HP:0002875)	2.13007893
53	Abnormal number of erythroid precursors (HP:0012131)	2.13006011
54	Progressive macrocephaly (HP:0004481)	2.11538129
55	Hypoplasia of the pons (HP:0012110)	2.11103901
56	Abnormality of the 4th metacarpal (HP:0010012)	2.06716659
57	Increased CSF lactate (HP:0002490)	2.03357809
58	Palpebral edema (HP:0100540)	2.03059593
59	Enlarged epiphyses (HP:0010580)	2.01326618
60	Gastrointestinal atresia (HP:0002589)	1.98600452
61	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.95314940
62	Muscle hypertrophy of the lower extremities (HP:0008968)	1.95232897
63	Bilateral microphthalmos (HP:0007633)	1.95139594
64	Abnormality of the septum pellucidum (HP:0007375)	1.94950136
65	Renal dysplasia (HP:0000110)	1.94611460
66	Abnormal respiratory epithelium morphology (HP:0012253)	1.94256312
67	Abnormal respiratory motile cilium morphology (HP:0005938)	1.94256312
68	Anencephaly (HP:0002323)	1.91860257
69	Congenital sensorineural hearing impairment (HP:0008527)	1.90475379
70	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.89099404
71	Optic disc pallor (HP:0000543)	1.88983659
72	Abnormal respiratory motile cilium physiology (HP:0012261)	1.88442189
73	Abnormality of the fovea (HP:0000493)	1.86382451
74	Cerebral edema (HP:0002181)	1.85398016
75	Abnormality of the pons (HP:0007361)	1.84730234
76	Sensory axonal neuropathy (HP:0003390)	1.84036413
77	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.82777040
78	Hypoplasia of the fovea (HP:0007750)	1.82777040
79	Meningioma (HP:0002858)	1.82652321
80	Aqueductal stenosis (HP:0002410)	1.81187224
81	Intestinal atresia (HP:0011100)	1.80426942
82	Birth length less than 3rd percentile (HP:0003561)	1.80324076
83	Respiratory distress (HP:0002098)	1.80290600
84	Male pseudohermaphroditism (HP:0000037)	1.79306985
85	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.79020677
86	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.79020677
87	Pheochromocytoma (HP:0002666)	1.78132399
88	Postaxial foot polydactyly (HP:0001830)	1.75572447
89	Hyperphosphaturia (HP:0003109)	1.74546346
90	Occipital encephalocele (HP:0002085)	1.74216590
91	Concave nail (HP:0001598)	1.73559285
92	Abnormality of cells of the erythroid lineage (HP:0012130)	1.72209493
93	Hypoplastic ischia (HP:0003175)	1.70789928
94	Shawl scrotum (HP:0000049)	1.70682325
95	Anophthalmia (HP:0000528)	1.69561323
96	Congenital, generalized hypertrichosis (HP:0004540)	1.69069773
97	Congenital primary aphakia (HP:0007707)	1.68206194
98	Large eyes (HP:0001090)	1.65654655
99	Hyperkalemia (HP:0002153)	1.65057003
100	Furrowed tongue (HP:0000221)	1.64298375

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	5.02975301
2	PLK4	4.30664676
3	TLK1	3.58455458
4	VRK2	3.57985684
5	INSRR	2.71771492
6	ACVR1B	2.61638682
7	BUB1	2.50155645
8	WNK4	2.48560552
9	BMPR1B	2.40242057
10	FRK	2.34469191
11	TAF1	2.25170851
12	VRK1	2.07780158
13	DDR2	2.04570583
14	ZAK	1.88955665
15	MUSK	1.84594212
16	TESK1	1.77331806
17	CDC7	1.71310404
18	GRK1	1.67989271
19	PLK2	1.60585581
20	TESK2	1.59787341
21	WEE1	1.58196105
22	PNCK	1.57121211
23	STK38L	1.51526746
24	WNK1	1.46693094
25	CCNB1	1.43368621
26	MAP3K9	1.42776431
27	TNIK	1.38870779
28	RPS6KA4	1.34942297
29	CDK7	1.29591078
30	CHEK2	1.21146889
31	DYRK2	1.17664091
32	BRSK2	1.04354464
33	STK39	1.04230016
34	DYRK3	1.03715300
35	PRKD3	1.02416907
36	MST4	1.00712730
37	PINK1	0.98743828
38	AURKA	0.98244497
39	MAP2K7	0.98165473
40	CAMK1G	0.97046755
41	PLK3	0.89015483
42	EPHA4	0.86050642
43	CAMK1D	0.84829022
44	STK38	0.82666485
45	MAPK13	0.79710529
46	STK3	0.77847117
47	PRKCG	0.77063840
48	MAP3K4	0.76737036
49	ATR	0.74634133
50	MAPKAPK5	0.72441034
51	MKNK2	0.71626781
52	STK16	0.70526987
53	CDK3	0.69151785
54	ADRBK2	0.67856846
55	PIK3CG	0.66864404
56	MAPKAPK3	0.65649421
57	NUAK1	0.64786532
58	TIE1	0.64189127
59	GRK5	0.62740708
60	OXSR1	0.61894373
61	TTK	0.59203838
62	BCKDK	0.59202189
63	TGFBR1	0.56876830
64	PRKCE	0.56546169
65	PHKG1	0.55080164
66	PHKG2	0.55080164
67	PLK1	0.54137140
68	PASK	0.53853916
69	TRPM7	0.53688755
70	DYRK1B	0.53349464
71	ATM	0.51976255
72	PRKG1	0.51064680
73	MAPK15	0.50076260
74	AURKB	0.48742121
75	CSNK1G2	0.48194111
76	WNK3	0.48064552
77	MAP3K8	0.47651544
78	KDR	0.46383130
79	CSNK2A1	0.45091175
80	SGK494	0.42648205
81	SGK223	0.42648205
82	GRK7	0.39436539
83	RPS6KA6	0.39336371
84	OBSCN	0.38616332
85	CAMK1	0.37779975
86	RPS6KA5	0.37489947
87	MOS	0.36726646
88	EPHB2	0.35736126
89	SGK2	0.33250855
90	ERBB4	0.32836319
91	SGK1	0.31915832
92	BRSK1	0.30335195
93	DAPK2	0.30148704
94	RPS6KC1	0.30079658
95	RPS6KL1	0.30079658
96	SRPK1	0.28366584
97	BMX	0.28128757
98	CASK	0.26667062
99	PRKAA2	0.26483167
100	MET	0.25689039

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.77218719
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.51437998
3	Homologous recombination_Homo sapiens_hsa03440	3.37095833
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.16166185
5	Non-homologous end-joining_Homo sapiens_hsa03450	2.96281423
6	Mismatch repair_Homo sapiens_hsa03430	2.92142224
7	Parkinsons disease_Homo sapiens_hsa05012	2.87910898
8	Proteasome_Homo sapiens_hsa03050	2.75112836
9	DNA replication_Homo sapiens_hsa03030	2.72422829
10	Huntingtons disease_Homo sapiens_hsa05016	2.27845874
11	Cardiac muscle contraction_Homo sapiens_hsa04260	2.24333013
12	Basal transcription factors_Homo sapiens_hsa03022	2.18621075
13	RNA polymerase_Homo sapiens_hsa03020	2.06294106
14	Fanconi anemia pathway_Homo sapiens_hsa03460	2.04295910
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.02113508
16	Folate biosynthesis_Homo sapiens_hsa00790	1.98595777
17	Phototransduction_Homo sapiens_hsa04744	1.96974003
18	Alzheimers disease_Homo sapiens_hsa05010	1.95249212
19	One carbon pool by folate_Homo sapiens_hsa00670	1.94111690
20	Nucleotide excision repair_Homo sapiens_hsa03420	1.83790372
21	Protein export_Homo sapiens_hsa03060	1.67843700
22	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.64057228
23	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.53689340
24	Spliceosome_Homo sapiens_hsa03040	1.44190123
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.42740375
26	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.37580440
27	Olfactory transduction_Homo sapiens_hsa04740	1.37462451
28	RNA transport_Homo sapiens_hsa03013	1.37449708
29	Base excision repair_Homo sapiens_hsa03410	1.36055008
30	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.33387708
31	Butanoate metabolism_Homo sapiens_hsa00650	1.32852337
32	RNA degradation_Homo sapiens_hsa03018	1.31187515
33	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.29310981
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.19740003
35	Nitrogen metabolism_Homo sapiens_hsa00910	1.17952109
36	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.12157700
37	Propanoate metabolism_Homo sapiens_hsa00640	1.08528792
38	Purine metabolism_Homo sapiens_hsa00230	1.07356341
39	Nicotine addiction_Homo sapiens_hsa05033	1.06377839
40	Pyrimidine metabolism_Homo sapiens_hsa00240	1.00357387
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.96770757
42	Linoleic acid metabolism_Homo sapiens_hsa00591	0.96514356
43	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.94290800
44	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.94032202
45	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.91509309
46	Basal cell carcinoma_Homo sapiens_hsa05217	0.91162377
47	Selenocompound metabolism_Homo sapiens_hsa00450	0.86601128
48	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.85674558
49	Fatty acid degradation_Homo sapiens_hsa00071	0.85602322
50	Retinol metabolism_Homo sapiens_hsa00830	0.84101709
51	Taste transduction_Homo sapiens_hsa04742	0.77969647
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.77138519
53	Fatty acid metabolism_Homo sapiens_hsa01212	0.72028565
54	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.69372817
55	Metabolic pathways_Homo sapiens_hsa01100	0.67949887
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.62621985
57	Pyruvate metabolism_Homo sapiens_hsa00620	0.61458256
58	Mineral absorption_Homo sapiens_hsa04978	0.58600910
59	Cell cycle_Homo sapiens_hsa04110	0.57702632
60	Fat digestion and absorption_Homo sapiens_hsa04975	0.56682992
61	Tyrosine metabolism_Homo sapiens_hsa00350	0.56373576
62	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.53810443
63	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.53635868
64	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.52657905
65	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.51780226
66	Phenylalanine metabolism_Homo sapiens_hsa00360	0.50300333
67	Alcoholism_Homo sapiens_hsa05034	0.48900573
68	mRNA surveillance pathway_Homo sapiens_hsa03015	0.48861674
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48182201
70	Oocyte meiosis_Homo sapiens_hsa04114	0.48127505
71	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.47230944
72	Ether lipid metabolism_Homo sapiens_hsa00565	0.46296213
73	p53 signaling pathway_Homo sapiens_hsa04115	0.45825443
74	Tryptophan metabolism_Homo sapiens_hsa00380	0.45766400
75	Regulation of autophagy_Homo sapiens_hsa04140	0.43435086
76	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.42856113
77	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.40839591
78	Steroid biosynthesis_Homo sapiens_hsa00100	0.40652620
79	Type I diabetes mellitus_Homo sapiens_hsa04940	0.40387701
80	Arginine and proline metabolism_Homo sapiens_hsa00330	0.39757591
81	Peroxisome_Homo sapiens_hsa04146	0.37974910
82	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.37921911
83	Insulin secretion_Homo sapiens_hsa04911	0.37159108
84	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.36488939
85	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.33495777
86	Wnt signaling pathway_Homo sapiens_hsa04310	0.33390596
87	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.32428020
88	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.32400348
89	Serotonergic synapse_Homo sapiens_hsa04726	0.31495241
90	Salivary secretion_Homo sapiens_hsa04970	0.30879105
91	Protein digestion and absorption_Homo sapiens_hsa04974	0.30174211
92	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.25904326
93	Tight junction_Homo sapiens_hsa04530	0.25694643
94	Histidine metabolism_Homo sapiens_hsa00340	0.25164290
95	Bile secretion_Homo sapiens_hsa04976	0.24435181
96	Morphine addiction_Homo sapiens_hsa05032	0.23079659
97	Allograft rejection_Homo sapiens_hsa05330	0.21298188
98	Hippo signaling pathway_Homo sapiens_hsa04390	0.21203111
99	cAMP signaling pathway_Homo sapiens_hsa04024	0.19876227
100	Circadian rhythm_Homo sapiens_hsa04710	0.18934267

PCGF7P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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