PCID2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the TREX-2 complex (transcription and export complex 2), which regulates mRNA export from the nucleus. This protein regulates expression of Mad2 mitotic arrest deficient-like 1, a cell division checkpoint protein. This protein also interacts with and stabilizes Brca2 (breast cancer 2) protein. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation (GO:0022616)4.67609131
2proteasome assembly (GO:0043248)4.66301647
3DNA strand elongation involved in DNA replication (GO:0006271)4.62745368
4DNA replication initiation (GO:0006270)4.53674242
5DNA unwinding involved in DNA replication (GO:0006268)4.42683968
6mitotic nuclear envelope disassembly (GO:0007077)4.40953660
7IMP biosynthetic process (GO:0006188)4.40181773
8protein localization to kinetochore (GO:0034501)4.40133495
9synapsis (GO:0007129)4.32012693
10somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)4.26972429
11somatic diversification of immunoglobulins involved in immune response (GO:0002208)4.26972429
12isotype switching (GO:0045190)4.26972429
13nucleobase biosynthetic process (GO:0046112)4.25905137
14telomere maintenance via semi-conservative replication (GO:0032201)4.18466823
15mitotic metaphase plate congression (GO:0007080)4.13340817
16membrane disassembly (GO:0030397)4.04810850
17nuclear envelope disassembly (GO:0051081)4.04810850
18attachment of spindle microtubules to kinetochore (GO:0008608)4.04412450
19rRNA modification (GO:0000154)3.96335998
20purine nucleobase biosynthetic process (GO:0009113)3.94337748
21DNA replication checkpoint (GO:0000076)3.94311915
22formation of translation preinitiation complex (GO:0001731)3.93666681
23protein localization to chromosome, centromeric region (GO:0071459)3.91767415
24double-strand break repair via nonhomologous end joining (GO:0006303)3.88308434
25non-recombinational repair (GO:0000726)3.88308434
26telomere maintenance via telomere lengthening (GO:0010833)3.88200992
27folic acid-containing compound biosynthetic process (GO:0009396)3.85439826
28rRNA methylation (GO:0031167)3.83070374
29nuclear pore organization (GO:0006999)3.82171260
30transcription from mitochondrial promoter (GO:0006390)3.81301750
31IMP metabolic process (GO:0046040)3.80769485
32mitotic sister chromatid segregation (GO:0000070)3.77936875
33somatic recombination of immunoglobulin gene segments (GO:0016447)3.76411774
34telomere maintenance via recombination (GO:0000722)3.74531269
35maturation of 5.8S rRNA (GO:0000460)3.74161317
36metaphase plate congression (GO:0051310)3.73571619
37mitochondrial RNA metabolic process (GO:0000959)3.64291563
38regulation of nuclear cell cycle DNA replication (GO:0033262)3.54718000
39regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.51874415
40mitotic recombination (GO:0006312)3.51388912
41DNA replication-dependent nucleosome organization (GO:0034723)3.49456158
42DNA replication-dependent nucleosome assembly (GO:0006335)3.49456158
43establishment of chromosome localization (GO:0051303)3.49266404
44negative regulation of ligase activity (GO:0051352)3.48069597
45negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.48069597
46somatic diversification of immunoglobulins (GO:0016445)3.45137345
47somatic hypermutation of immunoglobulin genes (GO:0016446)3.44314929
48somatic diversification of immune receptors via somatic mutation (GO:0002566)3.44314929
49DNA catabolic process, exonucleolytic (GO:0000738)3.44177648
50protein localization to chromosome (GO:0034502)3.41996188
51mismatch repair (GO:0006298)3.39673265
52histone exchange (GO:0043486)3.36848481
53DNA geometric change (GO:0032392)3.36313813
54DNA duplex unwinding (GO:0032508)3.36220030
55regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.35972030
56establishment of integrated proviral latency (GO:0075713)3.35788629
57nuclear pore complex assembly (GO:0051292)3.35311506
58ribosome biogenesis (GO:0042254)3.34646647
59sister chromatid segregation (GO:0000819)3.33895100
60meiotic chromosome segregation (GO:0045132)3.33747683
61ribosomal large subunit biogenesis (GO:0042273)3.31901483
62histone H2A acetylation (GO:0043968)3.31252883
63spliceosomal snRNP assembly (GO:0000387)3.30670574
64positive regulation of mitotic sister chromatid separation (GO:1901970)3.30444196
65positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.30444196
66positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.30444196
67DNA double-strand break processing (GO:0000729)3.28918159
68cullin deneddylation (GO:0010388)3.27125987
69DNA synthesis involved in DNA repair (GO:0000731)3.27032311
70regulation of double-strand break repair via homologous recombination (GO:0010569)3.26088198
71mitotic sister chromatid cohesion (GO:0007064)3.25048193
72regulation of spindle organization (GO:0090224)3.23683702
73pore complex assembly (GO:0046931)3.23621190
74somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.23332197
75somatic cell DNA recombination (GO:0016444)3.23332197
76mitotic chromosome condensation (GO:0007076)3.22186813
77rRNA processing (GO:0006364)3.20735037
78telomere maintenance via telomerase (GO:0007004)3.18864258
79regulation of mitochondrial translation (GO:0070129)3.16482253
80signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.15208515
81signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.15208515
82signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.15208515
83* regulation of mitotic spindle checkpoint (GO:1903504)3.15182273
84* regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.15182273
85termination of RNA polymerase III transcription (GO:0006386)3.14525685
86transcription elongation from RNA polymerase III promoter (GO:0006385)3.14525685
87piRNA metabolic process (GO:0034587)3.14436125
88regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.13912025
89nucleotide-excision repair, DNA gap filling (GO:0006297)3.13635366
90nuclear envelope organization (GO:0006998)3.12483183
91positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.12474450
92signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.11816400
93intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.11816400
94telomere organization (GO:0032200)3.11682760
95telomere maintenance (GO:0000723)3.11331723
96positive regulation of histone H3-K4 methylation (GO:0051571)3.10760848
97rRNA metabolic process (GO:0016072)3.09955899
98DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.09633638
99amino acid activation (GO:0043038)3.08882702
100tRNA aminoacylation (GO:0043039)3.08882702
101ribosome assembly (GO:0042255)3.08873595
102regulation of mitotic sister chromatid separation (GO:0010965)3.08656783
103regulation of mitotic sister chromatid segregation (GO:0033047)3.08656783
104regulation of sister chromatid segregation (GO:0033045)3.08656783
105signal transduction involved in DNA damage checkpoint (GO:0072422)3.08128102
106signal transduction involved in DNA integrity checkpoint (GO:0072401)3.08128102
107transcription-coupled nucleotide-excision repair (GO:0006283)3.07960213
108DNA deamination (GO:0045006)3.07720432
109negative regulation of chromosome segregation (GO:0051985)3.07622766
110CENP-A containing nucleosome assembly (GO:0034080)3.07040429
111DNA replication-independent nucleosome assembly (GO:0006336)3.05342236
112DNA replication-independent nucleosome organization (GO:0034724)3.05342236
113chromatin remodeling at centromere (GO:0031055)3.04551786
114regulation of centrosome cycle (GO:0046605)3.04537592
115kinetochore organization (GO:0051383)3.04317577
116anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.03880278
117negative regulation of mitotic sister chromatid separation (GO:2000816)3.03503909
118negative regulation of mitotic sister chromatid segregation (GO:0033048)3.03503909
119negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.03503909
120negative regulation of sister chromatid segregation (GO:0033046)3.03503909
121RNA-dependent DNA replication (GO:0006278)2.98786301
122negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.98480675
123mitotic spindle assembly checkpoint (GO:0007094)2.98023208
124regulation of telomere maintenance via telomerase (GO:0032210)2.97860904
125ribosomal small subunit assembly (GO:0000028)2.97341310
126regulation of chromosome segregation (GO:0051983)2.97202397
127spindle assembly checkpoint (GO:0071173)2.96826990
128negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.96584399
129regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.94271853
130protein deneddylation (GO:0000338)2.93534011
131spindle checkpoint (GO:0031577)2.93427369
132negative regulation of telomerase activity (GO:0051974)2.92645688
133DNA conformation change (GO:0071103)2.92295346
134spliceosomal tri-snRNP complex assembly (GO:0000244)2.91302407
135negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.90188842
136snRNA processing (GO:0016180)2.90132767
137cell cycle G1/S phase transition (GO:0044843)2.89886341
138G1/S transition of mitotic cell cycle (GO:0000082)2.89886341
139pseudouridine synthesis (GO:0001522)2.87836764
140histone arginine methylation (GO:0034969)2.87353414
141positive regulation of chromosome segregation (GO:0051984)2.87286028
142positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.87211376
143mitotic spindle checkpoint (GO:0071174)2.86622781
144viral mRNA export from host cell nucleus (GO:0046784)2.84987704
145RNA splicing, via transesterification reactions (GO:0000375)2.83659064
146RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.83250617
147mRNA splicing, via spliceosome (GO:0000398)2.83250617
148maturation of SSU-rRNA (GO:0030490)2.82691248
149regulation of centriole replication (GO:0046599)2.82390819
150peptidyl-arginine omega-N-methylation (GO:0035247)2.80638272
151snRNA metabolic process (GO:0016073)2.80614390
152maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.79436225
153regulation of mitotic metaphase/anaphase transition (GO:0030071)2.78825468

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.41308107
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.83402072
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.77447073
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.57628439
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.48838850
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.26593822
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.19559671
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.14358039
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.09244943
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.92665127
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.84214156
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.83225685
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.70806421
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70600145
15* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.67173587
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.60426226
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.53918222
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.52540472
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45984701
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.26428479
21XRN2_22483619_ChIP-Seq_HELA_Human2.21629054
22* VDR_23849224_ChIP-Seq_CD4+_Human2.18711256
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.09343865
24FOXP3_21729870_ChIP-Seq_TREG_Human2.05601741
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.04852290
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02214581
27THAP11_20581084_ChIP-Seq_MESCs_Mouse1.96600965
28AR_21909140_ChIP-Seq_LNCAP_Human1.96457777
29GABP_19822575_ChIP-Seq_HepG2_Human1.93971245
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92953877
31CIITA_25753668_ChIP-Seq_RAJI_Human1.92745312
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.92326694
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90229736
34MYC_22102868_ChIP-Seq_BL_Human1.88812088
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87923806
36* DCP1A_22483619_ChIP-Seq_HELA_Human1.87766520
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85743274
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.83828471
39* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81953312
40* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81563277
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80993835
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.74616181
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74570104
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71341511
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70831089
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70341034
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.61512685
48TTF2_22483619_ChIP-Seq_HELA_Human1.60782918
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.58544089
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.58271934
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52209770
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51770134
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49875397
54KDM5A_27292631_Chip-Seq_BREAST_Human1.49489989
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48099540
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47473526
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.43067530
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36967282
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36811720
60ELK1_19687146_ChIP-ChIP_HELA_Human1.35139176
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34380366
62* SRF_21415370_ChIP-Seq_HL-1_Mouse1.33518616
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32124977
64BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.29269801
65* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.28609205
66PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.25475249
67* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25252641
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22763513
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21515766
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.21447590
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20382732
72TFEB_21752829_ChIP-Seq_HELA_Human1.19824229
73SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.17825362
74EWS_26573619_Chip-Seq_HEK293_Human1.15671448
75* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13378194
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13295509
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12705314
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12477186
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.12172609
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11389484
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09525560
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08703690
83STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03705960
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03460338
85SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03164467
86* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02531632
87* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00897371
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00759344
89SPI1_23547873_ChIP-Seq_NB4_Human0.99890336
90VDR_21846776_ChIP-Seq_THP-1_Human0.99553059
91ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99137321
92NANOG_21062744_ChIP-ChIP_HESCs_Human0.97153073
93SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96345636
94ELK1_22589737_ChIP-Seq_MCF10A_Human0.95011909
95* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92856475
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90084535
97FUS_26573619_Chip-Seq_HEK293_Human0.90040225
98IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89112892
99FLI1_27457419_Chip-Seq_LIVER_Mouse0.88644599
100CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84856345
101SOX17_20123909_ChIP-Seq_XEN_Mouse0.82182102
102MYC_18940864_ChIP-ChIP_HL60_Human0.79685214
103FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77216710
104CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76675117
105KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.76350095
106NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.76006758
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75610744
108KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.75415763
109TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75370381
110ELF5_23300383_ChIP-Seq_T47D_Human0.74866928
111SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74000368
112CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.73257502
113ZNF274_21170338_ChIP-Seq_K562_Hela0.73143565
114HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.72934274
115ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.72333431
116MYB_26560356_Chip-Seq_TH1_Human0.71898685
117NANOG_16153702_ChIP-ChIP_HESCs_Human0.71841229
118RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.71621487
119NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.70070040
120MYB_26560356_Chip-Seq_TH2_Human0.69800190
121PCGF2_27294783_Chip-Seq_ESCs_Mouse0.68186367

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.44653208
2MP0010094_abnormal_chromosome_stability4.92871060
3MP0003111_abnormal_nucleus_morphology4.72426662
4MP0004957_abnormal_blastocyst_morpholog4.18732357
5MP0003077_abnormal_cell_cycle4.17056520
6MP0008057_abnormal_DNA_replication3.98639227
7MP0008058_abnormal_DNA_repair3.83233103
8MP0008877_abnormal_DNA_methylation3.06311652
9MP0008007_abnormal_cellular_replicative3.03039431
10MP0003123_paternal_imprinting3.00708229
11MP0002396_abnormal_hematopoietic_system2.53301273
12MP0008932_abnormal_embryonic_tissue2.46895530
13MP0001661_extended_life_span2.37449261
14MP0001730_embryonic_growth_arrest2.33726381
15MP0000350_abnormal_cell_proliferation2.22713220
16MP0009697_abnormal_copulation2.16372216
17MP0003763_abnormal_thymus_physiology1.89800531
18MP0003806_abnormal_nucleotide_metabolis1.85199499
19MP0010352_gastrointestinal_tract_polyps1.83167548
20MP0010307_abnormal_tumor_latency1.80958110
21MP0003121_genomic_imprinting1.77575733
22MP0001697_abnormal_embryo_size1.68869355
23MP0005380_embryogenesis_phenotype1.67658719
24MP0001672_abnormal_embryogenesis/_devel1.67658719
25MP0006072_abnormal_retinal_apoptosis1.62987768
26* MP0002080_prenatal_lethality1.62767526
27MP0009333_abnormal_splenocyte_physiolog1.62639889
28MP0000313_abnormal_cell_death1.58846719
29MP0002019_abnormal_tumor_incidence1.58077875
30MP0002210_abnormal_sex_determination1.57027527
31MP0001929_abnormal_gametogenesis1.54308909
32* MP0000490_abnormal_crypts_of1.53254621
33MP0003984_embryonic_growth_retardation1.51951262
34MP0002102_abnormal_ear_morphology1.49425955
35MP0006036_abnormal_mitochondrial_physio1.49052378
36MP0003718_maternal_effect1.48162966
37* MP0002398_abnormal_bone_marrow1.47758540
38MP0002088_abnormal_embryonic_growth/wei1.47716532
39* MP0004808_abnormal_hematopoietic_stem1.47335445
40* MP0000703_abnormal_thymus_morphology1.47190356
41MP0003950_abnormal_plasma_membrane1.44975085
42MP0003786_premature_aging1.38764519
43MP0005075_abnormal_melanosome_morpholog1.38671804
44MP0002085_abnormal_embryonic_tissue1.37213913
45MP0001145_abnormal_male_reproductive1.37084988
46MP0002084_abnormal_developmental_patter1.33470400
47MP0005397_hematopoietic_system_phenotyp1.33264096
48MP0001545_abnormal_hematopoietic_system1.33264096
49MP0006292_abnormal_olfactory_placode1.32041516
50* MP0000689_abnormal_spleen_morphology1.30290602
51MP0002653_abnormal_ependyma_morphology1.27587163
52MP0003787_abnormal_imprinting1.27108937
53MP0001853_heart_inflammation1.25317435
54MP0004185_abnormal_adipocyte_glucose1.24383874
55* MP0002722_abnormal_immune_system1.24325419
56MP0002006_tumorigenesis1.22203790
57MP0000653_abnormal_sex_gland1.21208515
58MP0005395_other_phenotype1.20092538
59MP0002086_abnormal_extraembryonic_tissu1.19831316
60MP0000015_abnormal_ear_pigmentation1.18760213
61MP0002009_preneoplasia1.18145077
62MP0004197_abnormal_fetal_growth/weight/1.12543789
63* MP0002429_abnormal_blood_cell1.11086656
64MP0000358_abnormal_cell_content/1.09559730
65MP0003890_abnormal_embryonic-extraembry1.08205990
66MP0002166_altered_tumor_susceptibility1.07412281
67MP0004233_abnormal_muscle_weight1.06471394
68MP0001293_anophthalmia1.05960327
69MP0008995_early_reproductive_senescence1.03212984
70MP0000858_altered_metastatic_potential1.03097633
71* MP0000716_abnormal_immune_system1.02250684
72MP0004264_abnormal_extraembryonic_tissu0.99790005
73MP0000372_irregular_coat_pigmentation0.99755595
74MP0003698_abnormal_male_reproductive0.99392711
75MP0001119_abnormal_female_reproductive0.98853694
76MP0005410_abnormal_fertilization0.96533025
77MP0002837_dystrophic_cardiac_calcinosis0.95346507
78MP0002163_abnormal_gland_morphology0.94037984
79MP0008875_abnormal_xenobiotic_pharmacok0.93593804
80MP0003567_abnormal_fetal_cardiomyocyte0.92391240
81MP0005384_cellular_phenotype0.91517600
82MP0003937_abnormal_limbs/digits/tail_de0.90512109
83MP0005671_abnormal_response_to0.90269793
84MP0009278_abnormal_bone_marrow0.86718426
85MP0002938_white_spotting0.86528196
86MP0001915_intracranial_hemorrhage0.86497142
87MP0003941_abnormal_skin_development0.84382845
88MP0002420_abnormal_adaptive_immunity0.83918920
89MP0001819_abnormal_immune_cell0.83242289
90MP0003186_abnormal_redox_activity0.83153765
91MP0001800_abnormal_humoral_immune0.82920620
92MP0006054_spinal_hemorrhage0.82650015
93MP0003315_abnormal_perineum_morphology0.82405316
94MP0008873_increased_physiological_sensi0.81860166
95MP0002161_abnormal_fertility/fecundity0.80436869
96MP0003221_abnormal_cardiomyocyte_apopto0.80374725
97MP0005621_abnormal_cell_physiology0.80358787
98MP0002269_muscular_atrophy0.77960978
99MP0001764_abnormal_homeostasis0.77391478
100MP0002452_abnormal_antigen_presenting0.76038067
101MP0000427_abnormal_hair_cycle0.75851471
102MP0005076_abnormal_cell_differentiation0.75679309
103MP0003656_abnormal_erythrocyte_physiolo0.73109417
104MP0001835_abnormal_antigen_presentation0.72877486
105MP0005389_reproductive_system_phenotype0.72295469
106MP0010030_abnormal_orbit_morphology0.71601593
107MP0002160_abnormal_reproductive_system0.70426769
108MP0004133_heterotaxia0.69163832
109MP0001529_abnormal_vocalization0.67925284
110MP0005253_abnormal_eye_physiology0.65909842
111MP0003183_abnormal_peptide_metabolism0.65240407
112MP0002723_abnormal_immune_serum0.65190674
113MP0005360_urolithiasis0.64671625
114MP0009672_abnormal_birth_weight0.63927298
115MP0002095_abnormal_skin_pigmentation0.63553146
116MP0003943_abnormal_hepatobiliary_system0.63134894
117MP0005408_hypopigmentation0.62458833
118MP0001286_abnormal_eye_development0.62215190
119MP0002075_abnormal_coat/hair_pigmentati0.62181927
120MP0001919_abnormal_reproductive_system0.62089506
121MP0000465_gastrointestinal_hemorrhage0.61802008
122MP0003699_abnormal_female_reproductive0.61420067
123MP0000371_diluted_coat_color0.60577343
124MP0005499_abnormal_olfactory_system0.60166960
125MP0005394_taste/olfaction_phenotype0.60166960
126MP0001986_abnormal_taste_sensitivity0.60119327
127MP0001849_ear_inflammation0.59560502
128MP0008789_abnormal_olfactory_epithelium0.59524335
129MP0004147_increased_porphyrin_level0.59229389
130MP0000013_abnormal_adipose_tissue0.59146327
131MP0002751_abnormal_autonomic_nervous0.58725963
132MP0006035_abnormal_mitochondrial_morpho0.58477986
133MP0005379_endocrine/exocrine_gland_phen0.53405616
134MP0000383_abnormal_hair_follicle0.52904344
135MP0003646_muscle_fatigue0.49490101

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.73354211
2Abnormality of the anterior horn cell (HP:0006802)5.40155096
3Degeneration of anterior horn cells (HP:0002398)5.40155096
4Breast hypoplasia (HP:0003187)4.10927280
5Ependymoma (HP:0002888)4.06855651
6Patellar aplasia (HP:0006443)3.76427899
7Agnosia (HP:0010524)3.55749863
8Aplasia/Hypoplasia of the patella (HP:0006498)3.42136907
9Selective tooth agenesis (HP:0001592)3.40271070
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.34768067
11Aplastic anemia (HP:0001915)3.29271990
12Type I transferrin isoform profile (HP:0003642)3.28755919
13Atrophy/Degeneration involving motor neurons (HP:0007373)3.28550142
14Cerebral hypomyelination (HP:0006808)3.18661229
15Chromsome breakage (HP:0040012)3.15123299
16Medulloblastoma (HP:0002885)3.09853692
17Oral leukoplakia (HP:0002745)3.06319405
18Myelodysplasia (HP:0002863)3.04253715
19Meckel diverticulum (HP:0002245)2.99356041
20Colon cancer (HP:0003003)2.94768719
21Abnormality of the labia minora (HP:0012880)2.94592727
22Abnormality of the preputium (HP:0100587)2.91654678
23Abnormality of the ileum (HP:0001549)2.91381750
24Increased CSF lactate (HP:0002490)2.91001117
25Astrocytoma (HP:0009592)2.87964987
26Abnormality of the astrocytes (HP:0100707)2.87964987
27Aplasia/Hypoplasia of the uvula (HP:0010293)2.85839380
28Abnormality of chromosome stability (HP:0003220)2.81534292
29Spinal muscular atrophy (HP:0007269)2.77907309
30Acute necrotizing encephalopathy (HP:0006965)2.76742202
31Bone marrow hypocellularity (HP:0005528)2.75506217
32Abnormal mitochondria in muscle tissue (HP:0008316)2.70298891
33Abnormal protein glycosylation (HP:0012346)2.69688646
34Abnormal glycosylation (HP:0012345)2.69688646
35Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.69688646
36Abnormal protein N-linked glycosylation (HP:0012347)2.69688646
37Hepatocellular necrosis (HP:0001404)2.69191527
38Hypoplasia of the capital femoral epiphysis (HP:0003090)2.67792612
39Absent thumb (HP:0009777)2.67182888
40Abnormality of methionine metabolism (HP:0010901)2.65847899
41Premature graying of hair (HP:0002216)2.65778642
42Mitochondrial inheritance (HP:0001427)2.64104249
43Increased hepatocellular lipid droplets (HP:0006565)2.63714120
44Reticulocytopenia (HP:0001896)2.63362638
45Supernumerary spleens (HP:0009799)2.63035307
46Amaurosis fugax (HP:0100576)2.58838894
47Overlapping toe (HP:0001845)2.57073731
48Rough bone trabeculation (HP:0100670)2.55447071
49Increased serum lactate (HP:0002151)2.54337229
50Cerebral edema (HP:0002181)2.53486662
51Nephroblastoma (Wilms tumor) (HP:0002667)2.48669723
52Hepatic necrosis (HP:0002605)2.46394762
53IgG deficiency (HP:0004315)2.46009825
54Stomatitis (HP:0010280)2.43211190
55Ectopic kidney (HP:0000086)2.42486515
56Rhabdomyosarcoma (HP:0002859)2.40938894
57Embryonal renal neoplasm (HP:0011794)2.40228260
58Posterior subcapsular cataract (HP:0007787)2.40080336
59Carpal bone hypoplasia (HP:0001498)2.39925074
60Freckling (HP:0001480)2.39825026
61Small intestinal stenosis (HP:0012848)2.39669284
62Duodenal stenosis (HP:0100867)2.39669284
63Cutaneous melanoma (HP:0012056)2.38904819
64Progressive macrocephaly (HP:0004481)2.38085369
65Acute encephalopathy (HP:0006846)2.37359945
66Glioma (HP:0009733)2.36015692
67Cellular immunodeficiency (HP:0005374)2.32705500
68Reduced antithrombin III activity (HP:0001976)2.32627815
69Lipid accumulation in hepatocytes (HP:0006561)2.32457687
70Basal cell carcinoma (HP:0002671)2.30557537
71Pancytopenia (HP:0001876)2.29386713
72Lymphoma (HP:0002665)2.28247193
73Abnormal number of erythroid precursors (HP:0012131)2.28112832
74Combined immunodeficiency (HP:0005387)2.27941865
75Neoplasm of the pancreas (HP:0002894)2.27449596
76Slender long bone (HP:0003100)2.26926329
77Abnormality of alanine metabolism (HP:0010916)2.25910234
78Hyperalaninemia (HP:0003348)2.25910234
79Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25910234
8011 pairs of ribs (HP:0000878)2.24340065
81Squamous cell carcinoma (HP:0002860)2.23434581
82IgA deficiency (HP:0002720)2.22186351
83Abnormal lung lobation (HP:0002101)2.21023412
84Muscle fiber atrophy (HP:0100295)2.20722094
85Multiple enchondromatosis (HP:0005701)2.20305227
86Impulsivity (HP:0100710)2.19959205
87Premature ovarian failure (HP:0008209)2.18507397
88Gonadotropin excess (HP:0000837)2.17844121
89Abnormality of aspartate family amino acid metabolism (HP:0010899)2.17780820
90Shawl scrotum (HP:0000049)2.17412409
91Cafe-au-lait spot (HP:0000957)2.16786551
92Abnormality of cells of the erythroid lineage (HP:0012130)2.14992447
93Reduced subcutaneous adipose tissue (HP:0003758)2.12950434
94Decreased activity of mitochondrial respiratory chain (HP:0008972)2.12254651
95Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.12254651
96Abnormality of the motor neurons (HP:0002450)2.12182320
97Abnormal neuron morphology (HP:0012757)2.12182320
98Thrombocytosis (HP:0001894)2.12168833
99Sloping forehead (HP:0000340)2.12104173
100Microretrognathia (HP:0000308)2.10807763
101Volvulus (HP:0002580)2.09916068
102Severe combined immunodeficiency (HP:0004430)2.09263237
103Hypoplasia of the pons (HP:0012110)2.08709015
104Abnormality of the umbilical cord (HP:0010881)2.05287775
105T lymphocytopenia (HP:0005403)2.04995465
106Optic nerve coloboma (HP:0000588)2.04955243
107Microvesicular hepatic steatosis (HP:0001414)2.03689701
108IgM deficiency (HP:0002850)2.02570147
109Homocystinuria (HP:0002156)2.00963756
110Abnormality of homocysteine metabolism (HP:0010919)2.00963756
111Tracheoesophageal fistula (HP:0002575)1.99553009
112Abnormality of the duodenum (HP:0002246)1.99360158
113Abnormality of glycolysis (HP:0004366)1.99223404
114Prominent nose (HP:0000448)1.99032644
115Sensory axonal neuropathy (HP:0003390)1.98726859
116High pitched voice (HP:0001620)1.98394715
117Abnormality of T cell physiology (HP:0011840)1.97859533
118Amniotic constriction ring (HP:0009775)1.97326056
119Abnormality of placental membranes (HP:0011409)1.97326056
120Entropion (HP:0000621)1.96630390
121Lactic acidosis (HP:0003128)1.96077279
122Abnormal number of incisors (HP:0011064)1.94074788
123Aplasia/Hypoplasia of the sternum (HP:0006714)1.93250372
124Prominent metopic ridge (HP:0005487)1.92561797
125Increased nuchal translucency (HP:0010880)1.92490834
126Abnormality of the pons (HP:0007361)1.92422945
127Abnormality of the carotid arteries (HP:0005344)1.91868988
128Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.91311705
129Type 2 muscle fiber atrophy (HP:0003554)1.91076657
130Abnormal spermatogenesis (HP:0008669)1.90986297
131Proximal placement of thumb (HP:0009623)1.90824711
132Neoplasm of the oral cavity (HP:0100649)1.89252010
133Methylmalonic acidemia (HP:0002912)1.88490932
134Pulmonary fibrosis (HP:0002206)1.88151273
135Atresia of the external auditory canal (HP:0000413)1.87268104
136Duplicated collecting system (HP:0000081)1.86172998
137Absent epiphyses (HP:0010577)1.85386012
138Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.85386012
139Aplasia/hypoplasia of the humerus (HP:0006507)1.84653960
140Trismus (HP:0000211)1.84193613
141Tongue fasciculations (HP:0001308)1.83619333
142Self-mutilation (HP:0000742)1.83024755
143Absent forearm bone (HP:0003953)1.82645890
144Aplasia involving forearm bones (HP:0009822)1.82645890
145Deviation of the thumb (HP:0009603)1.82214165
146Exercise intolerance (HP:0003546)1.81929803
147Increased intramyocellular lipid droplets (HP:0012240)1.81880551
148Rib fusion (HP:0000902)1.81414481
149Breast aplasia (HP:0100783)1.81198062
150Absent radius (HP:0003974)1.81119223
151Abnormality of sulfur amino acid metabolism (HP:0004339)1.81104480
152Renal cortical cysts (HP:0000803)1.81021566
153Neoplasm of the colon (HP:0100273)1.80600295
154Abnormality of T cell number (HP:0011839)1.80432796
155Neoplasm of striated muscle (HP:0009728)1.78209604
156Increased serum pyruvate (HP:0003542)1.76923406
157Clubbing of toes (HP:0100760)1.76767652
158Oligodactyly (hands) (HP:0001180)1.76589916

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.82500914
2CDC73.97002764
3TSSK63.12777827
4WEE13.10393139
5PLK42.99765623
6NEK12.94715879
7NEK22.85712751
8EIF2AK12.82082214
9ACVR1B2.36795727
10TTK2.30680022
11VRK12.30256414
12EEF2K2.24293390
13PDK22.18552742
14PASK2.08551406
15BCKDK2.02094333
16PLK31.95120344
17PLK11.93882765
18ATR1.86736411
19SRPK11.86695935
20STK101.86153258
21RPS6KB21.67090865
22TESK21.64243288
23EIF2AK31.62383257
24NUAK11.57538556
25TGFBR11.56394461
26CCNB11.55267762
27VRK21.51393953
28BRSK21.50989157
29STK41.48236654
30MAP4K11.45446304
31MKNK11.42470789
32CDK71.38904887
33TLK11.38193887
34NME11.38012214
35AURKB1.32606704
36CHEK11.30930902
37TRIM281.30920909
38BRSK11.28759194
39RPS6KA41.22612181
40STK31.19697274
41CDK81.19408309
42CDK41.17973857
43MST41.15717370
44MAP3K81.12040577
45CHEK21.11838301
46TXK1.11615833
47AURKA1.09493704
48MKNK21.08115581
49CDK121.06208996
50PAK41.05178254
51MET1.04969527
52STK161.03801434
53TAF11.02960881
54NME20.94245606
55PDK30.92446740
56PDK40.92446740
57PLK20.90394895
58CDK20.90002950
59ATM0.88720931
60BMPR1B0.87787175
61FLT30.87758178
62SCYL20.86999029
63TESK10.85943715
64PRKD30.85291627
65DAPK10.82068170
66MAP4K20.81589955
67PIM10.80044206
68ALK0.79139611
69EPHA20.78832016
70BRAF0.78271728
71CDK90.78182371
72NEK60.78099952
73MELK0.75832303
74MAP3K100.71226405
75CLK10.68950909
76ZAP700.68696431
77CDK10.67707874
78OXSR10.66148471
79GRK60.63990765
80ERBB40.62926595
81PIM20.60576237
82PAK10.59936349
83FGFR10.59354876
84PKN20.59232015
85CSNK2A20.58804632
86WNK30.58534160
87KIT0.57915086
88CSNK2A10.56775296
89RPS6KA50.56568295
90STK240.56547258
91MAPKAPK30.55744475
92AKT30.55677394
93LRRK20.53981328
94ZAK0.51761618
95CSF1R0.50836666
96DYRK30.46759677
97PNCK0.46432881
98PBK0.45570886
99CDK60.45497240
100CSNK1G30.43682215
101FRK0.43511580
102CSNK1G10.43112289
103CHUK0.41341334
104BTK0.41259887
105JAK30.39103912
106MAP2K30.38366580
107MST1R0.37997915
108DYRK20.37785845
109MAP3K130.36021602
110RPS6KB10.35804129
111BLK0.35749360
112KDR0.34231951
113MAPKAPK20.33910958
114RAF10.33811110
115MTOR0.32838307
116MAP3K140.32505290
117ITK0.32286652
118PRKCI0.32207550
119BRD40.32101631
120MAPK110.31937261
121CDK190.31935311
122ERBB30.30002212
123MAPKAPK50.29758013
124TYK20.28805751
125MAP3K120.28014263
126CSNK1E0.27525397
127CSNK1G20.27252861
128PRKDC0.27005582
129TEC0.26408967
130NEK90.25784936
131EIF2AK20.24425028
132MAPK140.24408828
133IRAK40.23495927

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.99992839
2Mismatch repair_Homo sapiens_hsa034304.43439056
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.36958614
4RNA polymerase_Homo sapiens_hsa030203.33693853
5Base excision repair_Homo sapiens_hsa034103.30660887
6Spliceosome_Homo sapiens_hsa030403.26226476
7Proteasome_Homo sapiens_hsa030503.18814666
8RNA transport_Homo sapiens_hsa030133.16444453
9Homologous recombination_Homo sapiens_hsa034403.03338884
10Cell cycle_Homo sapiens_hsa041102.96139646
11Nucleotide excision repair_Homo sapiens_hsa034202.84934367
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.61720084
13One carbon pool by folate_Homo sapiens_hsa006702.57408293
14Fanconi anemia pathway_Homo sapiens_hsa034602.28838376
15Pyrimidine metabolism_Homo sapiens_hsa002402.28104046
16RNA degradation_Homo sapiens_hsa030182.17239355
17Basal transcription factors_Homo sapiens_hsa030222.10458866
18Caffeine metabolism_Homo sapiens_hsa002321.91232280
19Ribosome_Homo sapiens_hsa030101.84045724
20Non-homologous end-joining_Homo sapiens_hsa034501.80719827
21mRNA surveillance pathway_Homo sapiens_hsa030151.74263231
22p53 signaling pathway_Homo sapiens_hsa041151.39004196
23Purine metabolism_Homo sapiens_hsa002301.38593255
24Epstein-Barr virus infection_Homo sapiens_hsa051691.38089341
25Vitamin B6 metabolism_Homo sapiens_hsa007501.34815038
26Propanoate metabolism_Homo sapiens_hsa006401.31250871
27Parkinsons disease_Homo sapiens_hsa050121.31026055
28Oxidative phosphorylation_Homo sapiens_hsa001901.28238158
29Biosynthesis of amino acids_Homo sapiens_hsa012301.20811810
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18899367
31Antigen processing and presentation_Homo sapiens_hsa046121.18150711
32Pentose phosphate pathway_Homo sapiens_hsa000301.11896201
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.09794094
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09273665
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08865648
36Oocyte meiosis_Homo sapiens_hsa041141.08122729
37Selenocompound metabolism_Homo sapiens_hsa004501.05579662
38Primary immunodeficiency_Homo sapiens_hsa053401.04345985
39Viral carcinogenesis_Homo sapiens_hsa052031.00083435
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96348595
41Herpes simplex infection_Homo sapiens_hsa051680.92059464
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91082093
43Fatty acid elongation_Homo sapiens_hsa000620.82599366
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81216530
45Protein export_Homo sapiens_hsa030600.79931972
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78534116
47HTLV-I infection_Homo sapiens_hsa051660.77122816
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75615191
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74917362
50Legionellosis_Homo sapiens_hsa051340.74288972
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71989603
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68792292
53Carbon metabolism_Homo sapiens_hsa012000.67232278
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65226788
55Colorectal cancer_Homo sapiens_hsa052100.64787050
56Alzheimers disease_Homo sapiens_hsa050100.64300400
57Apoptosis_Homo sapiens_hsa042100.62831863
58Fructose and mannose metabolism_Homo sapiens_hsa000510.60961401
59Sulfur metabolism_Homo sapiens_hsa009200.60719698
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59959986
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57861459
62Folate biosynthesis_Homo sapiens_hsa007900.54961845
63Measles_Homo sapiens_hsa051620.54896398
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54538024
65Notch signaling pathway_Homo sapiens_hsa043300.53081566
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53023869
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.50117417
68Thyroid cancer_Homo sapiens_hsa052160.49304805
69Acute myeloid leukemia_Homo sapiens_hsa052210.47207547
70N-Glycan biosynthesis_Homo sapiens_hsa005100.46419327
71Peroxisome_Homo sapiens_hsa041460.46326928
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45858095
73Shigellosis_Homo sapiens_hsa051310.44517711
74Alcoholism_Homo sapiens_hsa050340.44492222
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.44034552
76Systemic lupus erythematosus_Homo sapiens_hsa053220.43579731
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.43223468
78Small cell lung cancer_Homo sapiens_hsa052220.43102946
79Type I diabetes mellitus_Homo sapiens_hsa049400.41294751
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40151731
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39770855
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39609080
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39114734
84Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38360489
85MicroRNAs in cancer_Homo sapiens_hsa052060.36820616
86Hepatitis B_Homo sapiens_hsa051610.36577273
87Viral myocarditis_Homo sapiens_hsa054160.35994057
88Chronic myeloid leukemia_Homo sapiens_hsa052200.35607170
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35273859
90Glutathione metabolism_Homo sapiens_hsa004800.35017443
91TGF-beta signaling pathway_Homo sapiens_hsa043500.34894537
92mTOR signaling pathway_Homo sapiens_hsa041500.33700759
93Galactose metabolism_Homo sapiens_hsa000520.33098014
94Lysine degradation_Homo sapiens_hsa003100.32438802
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30931525
96Arginine biosynthesis_Homo sapiens_hsa002200.30546399
97Influenza A_Homo sapiens_hsa051640.29939396
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.29849990
99T cell receptor signaling pathway_Homo sapiens_hsa046600.29235508
100Sulfur relay system_Homo sapiens_hsa041220.28353660
101Steroid biosynthesis_Homo sapiens_hsa001000.27752639
102Non-small cell lung cancer_Homo sapiens_hsa052230.27619038
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26776790
104Hippo signaling pathway_Homo sapiens_hsa043900.25336516
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25100274
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.23750317
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23366831
108Allograft rejection_Homo sapiens_hsa053300.22227528
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.21253582
110Hematopoietic cell lineage_Homo sapiens_hsa046400.20080506
111Regulation of autophagy_Homo sapiens_hsa041400.17416081
112B cell receptor signaling pathway_Homo sapiens_hsa046620.17358250
113Pyruvate metabolism_Homo sapiens_hsa006200.16314988
114Graft-versus-host disease_Homo sapiens_hsa053320.16223766
115Pancreatic cancer_Homo sapiens_hsa052120.16095145
116Endometrial cancer_Homo sapiens_hsa052130.15591388
117Huntingtons disease_Homo sapiens_hsa050160.14993579
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.14675204
119HIF-1 signaling pathway_Homo sapiens_hsa040660.13297589
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.13285628
121Autoimmune thyroid disease_Homo sapiens_hsa053200.13097285
122Fatty acid metabolism_Homo sapiens_hsa012120.12784380
123FoxO signaling pathway_Homo sapiens_hsa040680.12770049
124Metabolic pathways_Homo sapiens_hsa011000.11566993
125Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.11379599
126Leishmaniasis_Homo sapiens_hsa051400.11193324
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.10803658
128Ether lipid metabolism_Homo sapiens_hsa005650.04308198
129Vitamin digestion and absorption_Homo sapiens_hsa049770.02760191
130Tryptophan metabolism_Homo sapiens_hsa003800.00251315
131Butanoate metabolism_Homo sapiens_hsa00650-0.0079790
132Pentose and glucuronate interconversions_Homo sapiens_hsa00040-0.0031344

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »