PCK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)9.06876584
2omega-hydroxylase P450 pathway (GO:0097267)7.54947875
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.00636183
4L-phenylalanine catabolic process (GO:0006559)7.00636183
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.73909272
6L-phenylalanine metabolic process (GO:0006558)6.73909272
7aromatic amino acid family catabolic process (GO:0009074)6.25440104
8* drug metabolic process (GO:0017144)5.85956325
9glyoxylate metabolic process (GO:0046487)5.61619083
10indole-containing compound catabolic process (GO:0042436)5.55877490
11indolalkylamine catabolic process (GO:0046218)5.55877490
12tryptophan catabolic process (GO:0006569)5.55877490
13cysteine metabolic process (GO:0006534)5.42653529
14alpha-linolenic acid metabolic process (GO:0036109)5.42000573
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.37315281
16uronic acid metabolic process (GO:0006063)5.35281242
17glucuronate metabolic process (GO:0019585)5.35281242
18lysine catabolic process (GO:0006554)5.33457723
19lysine metabolic process (GO:0006553)5.33457723
20kynurenine metabolic process (GO:0070189)5.28154790
21tryptophan metabolic process (GO:0006568)5.24260688
22sulfur amino acid catabolic process (GO:0000098)5.23626974
23bile acid biosynthetic process (GO:0006699)5.20850481
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.14948348
25urea cycle (GO:0000050)5.14470611
26urea metabolic process (GO:0019627)5.14470611
27ethanol metabolic process (GO:0006067)5.00566165
28serine family amino acid catabolic process (GO:0009071)4.95550589
29complement activation, alternative pathway (GO:0006957)4.94814347
30homocysteine metabolic process (GO:0050667)4.91273069
31amino-acid betaine metabolic process (GO:0006577)4.77550442
32nitrogen cycle metabolic process (GO:0071941)4.76799119
33regulation of triglyceride catabolic process (GO:0010896)4.75622622
34positive regulation of lipoprotein lipase activity (GO:0051006)4.72783259
35positive regulation of triglyceride lipase activity (GO:0061365)4.72783259
36regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.70435665
37angiotensin maturation (GO:0002003)4.64615941
38aromatic amino acid family metabolic process (GO:0009072)4.53836227
39fat-soluble vitamin biosynthetic process (GO:0042362)4.52915386
40intestinal absorption (GO:0050892)4.52527319
41bile acid metabolic process (GO:0008206)4.50756608
42regulation of protein activation cascade (GO:2000257)4.49706497
43negative regulation of fibrinolysis (GO:0051918)4.49092023
44alpha-amino acid catabolic process (GO:1901606)4.46785352
45protein carboxylation (GO:0018214)4.45266887
46peptidyl-glutamic acid carboxylation (GO:0017187)4.45266887
47tyrosine metabolic process (GO:0006570)4.44803725
48acetyl-CoA metabolic process (GO:0006084)4.41582560
49high-density lipoprotein particle remodeling (GO:0034375)4.40904933
50acylglycerol homeostasis (GO:0055090)4.37800999
51triglyceride homeostasis (GO:0070328)4.37800999
52complement activation, classical pathway (GO:0006958)4.37233680
53fatty acid beta-oxidation (GO:0006635)4.34827859
54protein activation cascade (GO:0072376)4.30754499
55complement activation (GO:0006956)4.29738139
56regulation of fibrinolysis (GO:0051917)4.28334952
57short-chain fatty acid metabolic process (GO:0046459)4.26849865
58oxidative demethylation (GO:0070989)4.26595564
59valine metabolic process (GO:0006573)4.25137086
60NADH metabolic process (GO:0006734)4.24652052
61regulation of complement activation (GO:0030449)4.23825329
62cellular ketone body metabolic process (GO:0046950)4.21884342
63cellular amino acid catabolic process (GO:0009063)4.21387847
64plasma lipoprotein particle clearance (GO:0034381)4.21276180
65hormone catabolic process (GO:0042447)4.20772933
66fatty acid oxidation (GO:0019395)4.20464277
67diacylglycerol metabolic process (GO:0046339)4.16677298
68drug transmembrane transport (GO:0006855)4.15078910
69positive regulation of fatty acid beta-oxidation (GO:0032000)4.14151566
70drug catabolic process (GO:0042737)4.13502434
71lipid oxidation (GO:0034440)4.12461195
72response to mercury ion (GO:0046689)4.11919745
73urate metabolic process (GO:0046415)4.07628648
74very-low-density lipoprotein particle assembly (GO:0034379)4.07007387
75fatty acid catabolic process (GO:0009062)4.04371405
762-oxoglutarate metabolic process (GO:0006103)4.03853542
77blood coagulation, intrinsic pathway (GO:0007597)4.02975732
78serine family amino acid metabolic process (GO:0009069)4.00526975
79coenzyme catabolic process (GO:0009109)3.97227556
80phenylpropanoid metabolic process (GO:0009698)3.96343269
81cellular modified amino acid catabolic process (GO:0042219)3.96048430
82acute-phase response (GO:0006953)3.95977584
83glutamate metabolic process (GO:0006536)3.95254355
84monocarboxylic acid catabolic process (GO:0072329)3.94039614
85positive regulation of lipid catabolic process (GO:0050996)3.93264285
86reverse cholesterol transport (GO:0043691)3.93044671
87protein-lipid complex remodeling (GO:0034368)3.92910953
88macromolecular complex remodeling (GO:0034367)3.92910953
89plasma lipoprotein particle remodeling (GO:0034369)3.92910953
90carboxylic acid catabolic process (GO:0046395)3.91733609
91organic acid catabolic process (GO:0016054)3.91733609
92indolalkylamine metabolic process (GO:0006586)3.91294031
93regulation of cholesterol esterification (GO:0010872)3.89600003
94ethanol oxidation (GO:0006069)3.85463316
95biotin metabolic process (GO:0006768)3.83508831
96negative regulation of sterol transport (GO:0032372)3.83464289
97negative regulation of cholesterol transport (GO:0032375)3.83464289
98cholesterol efflux (GO:0033344)3.82918892
99carnitine metabolic process (GO:0009437)3.81628089
100aspartate family amino acid catabolic process (GO:0009068)3.78685462
101opsonization (GO:0008228)3.78231720
102glycine metabolic process (GO:0006544)3.77872758
103cellular biogenic amine catabolic process (GO:0042402)3.77044544
104amine catabolic process (GO:0009310)3.77044544
105cellular glucuronidation (GO:0052695)3.77023208
106alkaloid metabolic process (GO:0009820)3.75608827
107benzene-containing compound metabolic process (GO:0042537)3.75222693
108exogenous drug catabolic process (GO:0042738)3.74480327
109phospholipid efflux (GO:0033700)3.70062573
110fatty acid transmembrane transport (GO:1902001)3.69358705
111plasma lipoprotein particle assembly (GO:0034377)3.68148498
112fibrinolysis (GO:0042730)3.68086329
113branched-chain amino acid catabolic process (GO:0009083)3.66312109
114regulation of bile acid biosynthetic process (GO:0070857)3.66084595
115bile acid and bile salt transport (GO:0015721)3.64402658
116branched-chain amino acid metabolic process (GO:0009081)3.64164208
117ketone body metabolic process (GO:1902224)3.63877764
118lipoprotein transport (GO:0042953)3.62351607
119negative regulation of hemostasis (GO:1900047)3.62007383
120negative regulation of blood coagulation (GO:0030195)3.62007383
121fructose metabolic process (GO:0006000)3.61332697
122serine family amino acid biosynthetic process (GO:0009070)3.60626194
123positive regulation of fatty acid oxidation (GO:0046321)3.60550495
124phospholipid homeostasis (GO:0055091)3.60186426
125negative regulation of lipase activity (GO:0060192)3.59394320
126plasma lipoprotein particle organization (GO:0071827)3.58640796
127regulation of humoral immune response (GO:0002920)3.58305692
128dicarboxylic acid biosynthetic process (GO:0043650)3.58215093
129imidazole-containing compound metabolic process (GO:0052803)3.57119528
130regulation of cholesterol homeostasis (GO:2000188)3.56415458
131negative regulation of protein activation cascade (GO:2000258)3.54836451
132lipoprotein metabolic process (GO:0042157)3.54573710
133regulation of sequestering of triglyceride (GO:0010889)3.53975865
134regulation of plasminogen activation (GO:0010755)3.53600237
135arginine metabolic process (GO:0006525)3.51945008
136positive regulation of fatty acid biosynthetic process (GO:0045723)3.50867583
137aldehyde catabolic process (GO:0046185)3.48102798
138low-density lipoprotein particle clearance (GO:0034383)3.47665792
139regulation of fatty acid beta-oxidation (GO:0031998)3.45246131
140flavonoid metabolic process (GO:0009812)3.45220253
141renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.44460511
142drug transport (GO:0015893)3.44048300
143S-adenosylmethionine metabolic process (GO:0046500)3.43062633
144protein-lipid complex subunit organization (GO:0071825)3.39371889
145cytolysis (GO:0019835)3.38243450
146renal system process involved in regulation of blood volume (GO:0001977)3.37057531
147intestinal cholesterol absorption (GO:0030299)3.35835783
148triglyceride catabolic process (GO:0019433)3.35328871
149cholesterol homeostasis (GO:0042632)3.33714797
150protein-lipid complex assembly (GO:0065005)3.31765758
151negative regulation of coagulation (GO:0050819)3.31398458
152sterol homeostasis (GO:0055092)3.28156745
153disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.26610833

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.85151899
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.45437952
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.68551038
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.13418033
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.89929351
6* FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.82406785
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.40223461
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.87174969
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.43430917
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.29408211
11* CLOCK_20551151_ChIP-Seq_293T_Human2.28418329
12* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.02414614
13* ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.7838357
14* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.95886943
15* FOXA2_19822575_ChIP-Seq_HepG2_Human1.58617281
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.55896213
17CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52858887
18GATA1_22025678_ChIP-Seq_K562_Human1.52532575
19* HNF4A_19822575_ChIP-Seq_HepG2_Human1.39305150
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.34306499
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31022812
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30155469
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28280783
24TCF4_18268006_ChIP-ChIP_LS174T_Human1.21339881
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18262321
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14673908
27ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13269822
28HTT_18923047_ChIP-ChIP_STHdh_Human1.07640219
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06658210
30SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03601139
31ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02563635
32RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01094880
33BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99644333
34CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97346187
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97211114
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95772063
37ZNF263_19887448_ChIP-Seq_K562_Human0.92492759
38ESR2_21235772_ChIP-Seq_MCF-7_Human0.92284600
39GATA4_25053715_ChIP-Seq_YYC3_Human0.90833286
40IRF8_22096565_ChIP-ChIP_GC-B_Human0.87867692
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.87487612
42ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87092237
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.85543122
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85343572
45Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.84255076
46PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.82042206
47* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.81753386
48ESR1_21235772_ChIP-Seq_MCF-7_Human0.81464217
49AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79175550
50PPAR_26484153_Chip-Seq_NCI-H1993_Human0.78353417
51SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76910279
52NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.75786308
53AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.75473651
54SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71866461
55FOXO3_23340844_ChIP-Seq_DLD1_Human0.71451423
56PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.71262487
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.70842595
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.69277487
59NRF2_20460467_ChIP-Seq_MEFs_Mouse0.69277487
60DNAJC2_21179169_ChIP-ChIP_NT2_Human0.68876249
61JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.67545087
62TRIM28_21343339_ChIP-Seq_HEK293_Human0.67146582
63HNFA_21074721_ChIP-Seq_CACO-2_Human0.66627950
64RAD21_21589869_ChIP-Seq_MESCs_Mouse0.66551471
65LXR_22292898_ChIP-Seq_THP-1_Human0.66426972
66CTCF_27219007_Chip-Seq_Bcells_Human0.66315021
67ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.65810479
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.65791440
69CEBPB_22108803_ChIP-Seq_LS180_Human0.64154995
70RXR_22108803_ChIP-Seq_LS180_Human0.63038468
71ESR1_15608294_ChIP-ChIP_MCF-7_Human0.62974616
72DROSHA_22980978_ChIP-Seq_HELA_Human0.62910791
73PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.62033814
74BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61866432
75BP1_19119308_ChIP-ChIP_Hs578T_Human0.61733962
76CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.61228329
77SA1_27219007_Chip-Seq_Bcells_Human0.60878553
78P63_26484246_Chip-Seq_KERATINOCYTES_Human0.60707726
79STAT3_1855785_ChIP-Seq_MESCs_Mouse0.60640094
80GATA2_21666600_ChIP-Seq_HMVEC_Human0.60395039
81SOX2_21211035_ChIP-Seq_LN229_Human0.60038893
82SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.59915858
83RARA_24833708_ChIP-Seq_LIVER_Mouse0.59238004
84EGR1_19032775_ChIP-ChIP_M12_Human0.58658334
85KAP1_22055183_ChIP-Seq_ESCs_Mouse0.58513410
86EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.58279726
87ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.57034295
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.56951987
89NFYA_21822215_ChIP-Seq_K562_Human0.56838894
90* CDX2_20551321_ChIP-Seq_CACO-2_Human0.56787062
91ETV2_25802403_ChIP-Seq_MESCs_Mouse0.56625562
92FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.56569023
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.56301328
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.55445143
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.55377746
96EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.55242456
97FOXA1_25552417_ChIP-Seq_VCAP_Human0.55231274
98GATA1_19941826_ChIP-Seq_K562_Human0.52975120
99TBX20_22328084_ChIP-Seq_HEART_Mouse0.52171088
100TBX20_22080862_ChIP-Seq_HEART_Mouse0.52171088
101MYC_19915707_ChIP-ChIP_AK7_Human0.51063763
102RARB_24833708_ChIP-Seq_LIVER_Mouse0.50331807
103ESR1_20079471_ChIP-ChIP_T-47D_Human0.50069537
104PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.49357283
105* GATA2_19941826_ChIP-Seq_K562_Human0.49185351
106* AR_20517297_ChIP-Seq_VCAP_Human0.48437677
107SOX2_20726797_ChIP-Seq_SW620_Human0.48389958
108CBP_21632823_ChIP-Seq_H3396_Human0.48147609
109BCAT_22108803_ChIP-Seq_LS180_Human0.47647984
110SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.47595264
111FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.47281683
112ESET_19884257_ChIP-Seq_ESCs_Mouse0.46645680
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.45904422
114GATA6_25053715_ChIP-Seq_YYC3_Human0.45841787
115GATA3_24758297_ChIP-Seq_MCF-7_Human0.44827227
116RACK7_27058665_Chip-Seq_MCF-7_Human0.44276502
117GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.43992706
118STAT1_17558387_ChIP-Seq_HELA_Human0.43258660
119SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.43125922
120TAF2_19829295_ChIP-Seq_ESCs_Human0.42951980
121PIAS1_25552417_ChIP-Seq_VCAP_Human0.42504264
122FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.42020132
123ERG_21242973_ChIP-ChIP_JURKAT_Human0.41361548
124CDX2_22108803_ChIP-Seq_LS180_Human0.41273493
125SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.40576543
126P53_21459846_ChIP-Seq_SAOS-2_Human0.39309515
127FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.38118821

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.59022345
2MP0005360_urolithiasis7.54604424
3MP0005365_abnormal_bile_salt5.71699519
4MP0005085_abnormal_gallbladder_physiolo5.58719648
5MP0008875_abnormal_xenobiotic_pharmacok4.70185279
6MP0010329_abnormal_lipoprotein_level3.68232647
7MP0003252_abnormal_bile_duct3.64167869
8MP0003806_abnormal_nucleotide_metabolis3.41439353
9* MP0005332_abnormal_amino_acid3.14108521
10MP0003195_calcinosis2.88144883
11MP0009840_abnormal_foam_cell2.60769021
12MP0004019_abnormal_vitamin_homeostasis2.59630599
13MP0003191_abnormal_cellular_cholesterol2.56965700
14MP0001666_abnormal_nutrient_absorption2.31758969
15* MP0002118_abnormal_lipid_homeostasis2.31757240
16MP0005083_abnormal_biliary_tract2.28076426
17* MP0000609_abnormal_liver_physiology2.15024942
18MP0002138_abnormal_hepatobiliary_system2.06697614
19MP0005319_abnormal_enzyme/_coenzyme1.89762777
20MP0009643_abnormal_urine_homeostasis1.78815627
21MP0003183_abnormal_peptide_metabolism1.77238670
22* MP0005670_abnormal_white_adipose1.76424263
23MP0005584_abnormal_enzyme/coenzyme_acti1.76280593
24MP0001764_abnormal_homeostasis1.71865409
25MP0004130_abnormal_muscle_cell1.71675293
26MP0003186_abnormal_redox_activity1.60458447
27* MP0005666_abnormal_adipose_tissue1.53362850
28MP0002876_abnormal_thyroid_physiology1.47500397
29MP0003868_abnormal_feces_composition1.44505048
30MP0005451_abnormal_body_composition1.36451258
31MP0003705_abnormal_hypodermis_morpholog1.32600524
32* MP0002971_abnormal_brown_adipose1.32466694
33MP0004264_abnormal_extraembryonic_tissu1.25839010
34MP0005535_abnormal_body_temperature1.21656736
35MP0005636_abnormal_mineral_homeostasis1.21172514
36MP0005409_darkened_coat_color1.18899125
37MP0001756_abnormal_urination1.16478729
38MP0003879_abnormal_hair_cell1.16206864
39MP0006036_abnormal_mitochondrial_physio1.13979527
40MP0001661_extended_life_span1.13476358
41MP0004185_abnormal_adipocyte_glucose1.12404762
42* MP0000598_abnormal_liver_morphology1.11074212
43MP0003011_delayed_dark_adaptation1.10861717
44MP0010155_abnormal_intestine_physiology1.09174418
45MP0004043_abnormal_pH_regulation1.08378513
46* MP0005334_abnormal_fat_pad1.07885281
47MP0004147_increased_porphyrin_level1.07598225
48MP0009697_abnormal_copulation1.03557651
49MP0002254_reproductive_system_inflammat1.01888389
50MP0002837_dystrophic_cardiac_calcinosis1.01266751
51MP0005647_abnormal_sex_gland1.00409426
52MP0009764_decreased_sensitivity_to1.00264987
53* MP0002078_abnormal_glucose_homeostasis0.99790296
54MP0009763_increased_sensitivity_to0.96074174
55MP0000604_amyloidosis0.94881752
56MP0003656_abnormal_erythrocyte_physiolo0.92856507
57MP0002136_abnormal_kidney_physiology0.91670368
58MP0009379_abnormal_foot_pigmentation0.91495619
59* MP0009642_abnormal_blood_homeostasis0.90346462
60* MP0005375_adipose_tissue_phenotype0.89774772
61MP0003690_abnormal_glial_cell0.87841853
62MP0008469_abnormal_protein_level0.84375160
63MP0002132_abnormal_respiratory_system0.83193773
64MP0005084_abnormal_gallbladder_morpholo0.80909518
65MP0005448_abnormal_energy_balance0.80641835
66MP0003866_abnormal_defecation0.80594722
67MP0005166_decreased_susceptibility_to0.80265937
68* MP0009115_abnormal_fat_cell0.79639294
69MP0005376_homeostasis/metabolism_phenot0.76432169
70MP0001664_abnormal_digestion0.75227578
71MP0003724_increased_susceptibility_to0.73984261
72* MP0002970_abnormal_white_adipose0.70985271
73MP0009765_abnormal_xenobiotic_induced0.70668294
74MP0000566_synostosis0.69158152
75MP0001765_abnormal_ion_homeostasis0.68564366
76MP0003959_abnormal_lean_body0.65987145
77MP0010368_abnormal_lymphatic_system0.65891024
78MP0000477_abnormal_intestine_morphology0.63762923
79MP0008438_abnormal_cutaneous_collagen0.62620006
80MP0005266_abnormal_metabolism0.61940582
81MP0002168_other_aberrant_phenotype0.60897059
82MP0005220_abnormal_exocrine_pancreas0.60209605
83MP0000230_abnormal_systemic_arterial0.59845972
84MP0000678_abnormal_parathyroid_gland0.59408778
85MP0005058_abnormal_lysosome_morphology0.59314538
86MP0003953_abnormal_hormone_level0.59147469
87MP0005408_hypopigmentation0.58192582
88MP0003329_amyloid_beta_deposits0.57148637
89MP0001663_abnormal_digestive_system0.56472752
90MP0006035_abnormal_mitochondrial_morpho0.54416156
91MP0002796_impaired_skin_barrier0.53789763
92MP0009785_altered_susceptibility_to0.53625563
93MP0006138_congestive_heart_failure0.52391725
94MP0005395_other_phenotype0.51132124
95MP0002249_abnormal_larynx_morphology0.49073941
96MP0008961_abnormal_basal_metabolism0.48204532
97MP0003638_abnormal_response/metabolism_0.47995601
98MP0002928_abnormal_bile_duct0.47810986
99MP0001501_abnormal_sleep_pattern0.47042554
100MP0001881_abnormal_mammary_gland0.45792411
101MP0008872_abnormal_physiological_respon0.45515882
102MP0009672_abnormal_birth_weight0.45298210
103* MP0005452_abnormal_adipose_tissue0.42396401
104MP0001845_abnormal_inflammatory_respons0.41580669
105MP0005381_digestive/alimentary_phenotyp0.41036332
106MP0008874_decreased_physiological_sensi0.40650952
107MP0003075_altered_response_to0.40369148
108MP0000003_abnormal_adipose_tissue0.39502281
109MP0010352_gastrointestinal_tract_polyps0.39469172
110MP0004782_abnormal_surfactant_physiolog0.38713120
111MP0000013_abnormal_adipose_tissue0.38397831
112MP0002135_abnormal_kidney_morphology0.37982987
113MP0009053_abnormal_anal_canal0.37177228
114MP0000467_abnormal_esophagus_morphology0.37061010
115MP0002909_abnormal_adrenal_gland0.36813424
116MP0000639_abnormal_adrenal_gland0.36759097
117MP0003718_maternal_effect0.36561636
118MP0002822_catalepsy0.36166806
119MP0005275_abnormal_skin_tensile0.36131097
120MP0002060_abnormal_skin_morphology0.35536300
121MP0008873_increased_physiological_sensi0.34815774
122MP0000249_abnormal_blood_vessel0.34601841
123MP0005167_abnormal_blood-brain_barrier0.34117091
124MP0000538_abnormal_urinary_bladder0.33606514
125MP0002896_abnormal_bone_mineralization0.32927118
126MP0010234_abnormal_vibrissa_follicle0.32597582
127MP0005164_abnormal_response_to0.31885687

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.42761756
2Deep venous thrombosis (HP:0002625)5.93910533
3Intrahepatic cholestasis (HP:0001406)5.90285720
4Xanthomatosis (HP:0000991)5.78735199
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.57784967
6Hyperglycinuria (HP:0003108)5.36074432
7Prolonged partial thromboplastin time (HP:0003645)5.00625995
8Hypobetalipoproteinemia (HP:0003563)4.96888350
9Abnormality of glutamine family amino acid metabolism (HP:0010902)4.91077138
10Abnormality of serine family amino acid metabolism (HP:0010894)4.88951912
11Abnormality of glycine metabolism (HP:0010895)4.88951912
12Complement deficiency (HP:0004431)4.88110400
13Hyperlipoproteinemia (HP:0010980)4.85849172
14Hyperammonemia (HP:0001987)4.82285089
15Ketosis (HP:0001946)4.71820913
16Hyperglycinemia (HP:0002154)4.59225743
17Epidermoid cyst (HP:0200040)4.22422034
18Metabolic alkalosis (HP:0200114)4.14874311
19Hyperactive renin-angiotensin system (HP:0000841)4.14012844
20Abnormality of aspartate family amino acid metabolism (HP:0010899)4.13531514
21Hypoglycemic coma (HP:0001325)4.10631557
22Abnormality of fatty-acid metabolism (HP:0004359)4.08026936
23Hypolipoproteinemia (HP:0010981)4.07253997
24Abnormality of sulfur amino acid metabolism (HP:0004339)3.92831579
25Hypoalphalipoproteinemia (HP:0003233)3.90502222
26Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.84381310
27Joint hemorrhage (HP:0005261)3.83849906
28Ketoacidosis (HP:0001993)3.78356720
29Abnormality of the common coagulation pathway (HP:0010990)3.58467642
30Abnormality of methionine metabolism (HP:0010901)3.57549689
31Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.56290863
32Gout (HP:0001997)3.55472887
33Abnormality of complement system (HP:0005339)3.49209370
34Abnormality of purine metabolism (HP:0004352)3.43312145
35Abnormality of nucleobase metabolism (HP:0010932)3.35499016
36Nephritis (HP:0000123)3.35399235
37Fat malabsorption (HP:0002630)3.26944805
38Hypercholesterolemia (HP:0003124)3.22320874
39Abnormality of dicarboxylic acid metabolism (HP:0010995)3.21141159
40Dicarboxylic aciduria (HP:0003215)3.21141159
41Abnormality of pyrimidine metabolism (HP:0004353)3.19872757
42Abnormality of serum amino acid levels (HP:0003112)3.16291575
43Delayed CNS myelination (HP:0002188)3.13397280
44Increased circulating renin level (HP:0000848)3.09554441
45Potter facies (HP:0002009)3.04689872
46Facial shape deformation (HP:0011334)3.04689872
47Metabolic acidosis (HP:0001942)2.99382731
48Generalized aminoaciduria (HP:0002909)2.99360071
49Hydroxyprolinuria (HP:0003080)2.97461992
50Abnormality of proline metabolism (HP:0010907)2.97461992
51Abnormality of the intrinsic pathway (HP:0010989)2.96043335
52Conjugated hyperbilirubinemia (HP:0002908)2.93004252
53Lethargy (HP:0001254)2.88781117
54Proximal tubulopathy (HP:0000114)2.87583370
55Hyperbilirubinemia (HP:0002904)2.82335479
56Myocardial infarction (HP:0001658)2.77624696
57Hepatocellular carcinoma (HP:0001402)2.76815379
58Abnormality of vitamin metabolism (HP:0100508)2.76394330
59Abnormality of renin-angiotensin system (HP:0000847)2.74604019
60Increased purine levels (HP:0004368)2.74083522
61Hyperuricemia (HP:0002149)2.74083522
62Skin nodule (HP:0200036)2.63415573
63Ileus (HP:0002595)2.58972032
64Widely patent fontanelles and sutures (HP:0004492)2.58353788
65Alkalosis (HP:0001948)2.57094437
66Systemic lupus erythematosus (HP:0002725)2.56497619
67Cerebral edema (HP:0002181)2.56475449
68Abnormality of chloride homeostasis (HP:0011422)2.55607426
69Vascular calcification (HP:0004934)2.51853971
70Hyperphosphaturia (HP:0003109)2.50589768
71Hyperaldosteronism (HP:0000859)2.48667179
72Vomiting (HP:0002013)2.47720322
73Pancreatitis (HP:0001733)2.43100893
74Hypertriglyceridemia (HP:0002155)2.42399357
75Spastic diplegia (HP:0001264)2.41014900
76Irritability (HP:0000737)2.39492212
77Steatorrhea (HP:0002570)2.36249743
78Enlarged kidneys (HP:0000105)2.35891026
79Hypoglycemic seizures (HP:0002173)2.32963280
80Pigmentary retinal degeneration (HP:0001146)2.30908395
81Neonatal onset (HP:0003623)2.30185822
82Cardiovascular calcification (HP:0011915)2.29945043
83Spontaneous abortion (HP:0005268)2.28011284
84Hypophosphatemia (HP:0002148)2.27619863
85Hypokalemia (HP:0002900)2.27013253
86Abnormal urine phosphate concentration (HP:0012599)2.25221637
87Confusion (HP:0001289)2.24400934
88Focal segmental glomerulosclerosis (HP:0000097)2.22522476
89Abnormality of urine glucose concentration (HP:0011016)2.21921304
90Glycosuria (HP:0003076)2.21921304
91Abnormality of the vitamin B12 metabolism (HP:0004341)2.20904072
92Malnutrition (HP:0004395)2.20598376
93Gingival bleeding (HP:0000225)2.18759144
94Sensorimotor neuropathy (HP:0007141)2.18311073
95Hemorrhage of the eye (HP:0011885)2.15551792
96Nausea (HP:0002018)2.13927761
97Abnormality of magnesium homeostasis (HP:0004921)2.12817094
98Abnormal cartilage morphology (HP:0002763)2.12018623
99Osteomalacia (HP:0002749)2.11813549
100Abnormality of vitamin B metabolism (HP:0004340)2.11538973
101Abdominal distention (HP:0003270)2.11288673
102Brushfield spots (HP:0001088)2.09945957
103Late onset (HP:0003584)2.09612476
104Amyloidosis (HP:0011034)2.08870825
105Mitral stenosis (HP:0001718)2.04606107
106Myoglobinuria (HP:0002913)2.02360585
107Glomerulonephritis (HP:0000099)2.00887237
108Abnormal gallbladder morphology (HP:0012437)2.00477184
109Rickets (HP:0002748)2.00311742
110Hypophosphatemic rickets (HP:0004912)1.98572919
111Cholelithiasis (HP:0001081)1.97842575
112Esophageal varix (HP:0002040)1.96713947
113Hypotension (HP:0002615)1.96050331
114Oligomenorrhea (HP:0000876)1.95893329
115Renal cortical cysts (HP:0000803)1.95848863
116Megaloblastic anemia (HP:0001889)1.95712914
117Hypochromic microcytic anemia (HP:0004840)1.95003081
118Abnormal urine output (HP:0012590)1.94893936
119Elevated alkaline phosphatase (HP:0003155)1.94458626
120Abnormality of alkaline phosphatase activity (HP:0004379)1.94441825
121Acanthocytosis (HP:0001927)1.93203388
122Nephrolithiasis (HP:0000787)1.92203464
123Cerebral palsy (HP:0100021)1.90103388
124Abnormal enzyme/coenzyme activity (HP:0012379)1.89651737
125Thrombophlebitis (HP:0004418)1.88931855
126Elevated hepatic transaminases (HP:0002910)1.84946361
127Hyperinsulinemic hypoglycemia (HP:0000825)1.84278295
128Abnormal gallbladder physiology (HP:0012438)1.83302582
129Cholecystitis (HP:0001082)1.83302582
130Opisthotonus (HP:0002179)1.79456194
131Recurrent gram-negative bacterial infections (HP:0005420)1.76643797
132Hyperglycemia (HP:0003074)1.75647243
133Hypokalemic alkalosis (HP:0001949)1.73621026

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.10691718
2ACVR1B4.90133186
3SIK14.29940772
4FGFR43.53834291
5ERN13.53636066
6TRIB33.06865492
7CAMK1D2.88849955
8INSRR2.86326900
9MST1R2.54615829
10EPHA22.45908084
11WNK42.21539484
12PRKG21.99155032
13PDK41.97815118
14PDK31.97815118
15WNK31.96061646
16CAMK1G1.94973891
17ERBB41.93229599
18OXSR11.69429103
19PRKAA21.63499964
20FRK1.63173815
21PKN21.60921532
22MAPK111.59812490
23TAOK31.57912811
24MAP2K41.57637587
25LATS11.55747729
26MAP3K21.39147150
27RIPK11.37188974
28FGFR21.36799893
29DDR21.32076816
30STK38L1.31202095
31PINK11.28555334
32NLK1.23769530
33FLT31.22719729
34ABL21.21076660
35PDK21.18498524
36NEK91.16915270
37AKT31.15373074
38PTK61.10802580
39TIE11.09897194
40TYK21.08250129
41JAK21.06661140
42DAPK21.02086379
43MAP3K70.99900393
44PIK3CG0.98294197
45JAK10.97296600
46PRKAA10.96753977
47MET0.94321960
48MAP3K10.91465557
49TGFBR20.91082795
50KDR0.89305372
51FGFR30.86617400
52GSK3A0.85373916
53CDK60.84496825
54SGK30.84479128
55MAP2K30.84029157
56EPHA40.82650019
57EPHB10.81695520
58SGK2230.81566472
59SGK4940.81566472
60PDPK10.81147052
61GRK60.79211102
62PRKACG0.78378093
63MAP3K30.77657446
64MAP3K120.77067027
65IRAK30.76827082
66PRPF4B0.75584198
67PRKCZ0.73272525
68MAPK40.70941830
69STK390.69287684
70MAPK120.65686225
71TBK10.64366572
72SGK20.63707621
73ERBB20.62607565
74CSK0.62267915
75CAMKK20.59789299
76MAP2K20.59046973
77MAP2K10.56168696
78CDC42BPA0.56049773
79KSR20.55849012
80PDK10.55354659
81MAP3K60.55171262
82MAP3K140.54890103
83PIK3CA0.50931880
84MAP3K100.49886942
85NTRK30.49724130
86MATK0.48845641
87SRC0.48592859
88IGF1R0.48487817
89MTOR0.47760588
90PDGFRA0.47626020
91DYRK1B0.47232151
92EPHA30.47151739
93PRKCA0.46483257
94PTK20.45524118
95PRKACA0.44922205
96STK240.43958171
97PRKG10.43421532
98YES10.42085304
99LMTK20.40855590
100STK380.38703402
101EPHB20.38414437
102CSF1R0.38107480
103CDK40.37617994
104CAMK2G0.37512044
105RET0.37140832
106NEK10.36174135
107NEK60.35407383
108IRAK20.35177002
109PRKCH0.34119336
110IRAK10.33908313
111MAPK150.33561627
112MAP3K110.32969660
113CSNK1G10.31613993
114SGK10.30835506
115FER0.29630002
116ICK0.29137973
117MAPK70.28139085
118MAP2K60.27867844
119TESK10.27863800
120EEF2K0.26993036
121LATS20.25565618
122PRKCQ0.25409477
123MAPK30.24955744
124MYLK0.24920434
125CAMK2D0.24575049
126BMX0.24395689
127MAPKAPK30.24176593
128CSNK1A10.24027329
129IKBKE0.23985896
130CDK90.22917677
131GRK10.19616126

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.85872061
2Nitrogen metabolism_Homo sapiens_hsa009103.38385298
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.13191785
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.01445560
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.89521872
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.83644701
7Fatty acid degradation_Homo sapiens_hsa000712.83581156
8Arginine biosynthesis_Homo sapiens_hsa002202.79178597
9Propanoate metabolism_Homo sapiens_hsa006402.72463608
10Tryptophan metabolism_Homo sapiens_hsa003802.62074957
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.52840166
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.40845085
13Butanoate metabolism_Homo sapiens_hsa006502.40831433
14* PPAR signaling pathway_Homo sapiens_hsa033202.29460694
15Complement and coagulation cascades_Homo sapiens_hsa046102.27068024
16Fatty acid metabolism_Homo sapiens_hsa012122.26692396
17Peroxisome_Homo sapiens_hsa041462.25140092
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24281471
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.07480196
20beta-Alanine metabolism_Homo sapiens_hsa004101.93361884
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.88856142
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75726578
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68571599
24Caffeine metabolism_Homo sapiens_hsa002321.67549147
25Chemical carcinogenesis_Homo sapiens_hsa052041.65203787
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.64399440
27Histidine metabolism_Homo sapiens_hsa003401.64220377
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.61721623
29* Pyruvate metabolism_Homo sapiens_hsa006201.61332679
30Phenylalanine metabolism_Homo sapiens_hsa003601.59064901
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.57794139
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.51325765
33Staphylococcus aureus infection_Homo sapiens_hsa051501.50189396
34Bile secretion_Homo sapiens_hsa049761.45783976
35Carbon metabolism_Homo sapiens_hsa012001.44446025
36Retinol metabolism_Homo sapiens_hsa008301.43301214
37Fatty acid elongation_Homo sapiens_hsa000621.41877208
38Selenocompound metabolism_Homo sapiens_hsa004501.36958778
39Tyrosine metabolism_Homo sapiens_hsa003501.35241365
40Sulfur metabolism_Homo sapiens_hsa009201.34632538
41Starch and sucrose metabolism_Homo sapiens_hsa005001.30452311
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23350867
43Biosynthesis of amino acids_Homo sapiens_hsa012301.22611580
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22015434
45Fat digestion and absorption_Homo sapiens_hsa049751.19268298
46* Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17665057
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.17081781
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.14376889
49ABC transporters_Homo sapiens_hsa020101.11639448
50Glycerolipid metabolism_Homo sapiens_hsa005611.11497795
51Fatty acid biosynthesis_Homo sapiens_hsa000611.11343327
52Folate biosynthesis_Homo sapiens_hsa007901.07977462
53* Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01773731
54Vitamin digestion and absorption_Homo sapiens_hsa049770.97615217
55Lysine degradation_Homo sapiens_hsa003100.91878762
56Arginine and proline metabolism_Homo sapiens_hsa003300.89953225
57Steroid biosynthesis_Homo sapiens_hsa001000.85746707
58Vitamin B6 metabolism_Homo sapiens_hsa007500.83574868
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79367295
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79122575
61Sulfur relay system_Homo sapiens_hsa041220.78726949
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.74911783
63Glutathione metabolism_Homo sapiens_hsa004800.73328315
64* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69706967
65Pentose phosphate pathway_Homo sapiens_hsa000300.68610721
66* Metabolic pathways_Homo sapiens_hsa011000.47846575
67* Adipocytokine signaling pathway_Homo sapiens_hsa049200.42555542
68One carbon pool by folate_Homo sapiens_hsa006700.41806678
69Fructose and mannose metabolism_Homo sapiens_hsa000510.38652992
70* Insulin resistance_Homo sapiens_hsa049310.34200530
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28626009
72* AMPK signaling pathway_Homo sapiens_hsa041520.27950218
73Pertussis_Homo sapiens_hsa051330.26366351
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25695374
75Galactose metabolism_Homo sapiens_hsa000520.25186568
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.24888916
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.22848345
78Other glycan degradation_Homo sapiens_hsa005110.20850911
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19394174
80* Glucagon signaling pathway_Homo sapiens_hsa049220.18204571
81Prion diseases_Homo sapiens_hsa050200.16852565
82Linoleic acid metabolism_Homo sapiens_hsa005910.13695531
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13590259
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11133942
85Sphingolipid metabolism_Homo sapiens_hsa006000.06740048
86Ether lipid metabolism_Homo sapiens_hsa005650.06078929
87* Insulin signaling pathway_Homo sapiens_hsa049100.02796677
88Renin-angiotensin system_Homo sapiens_hsa046140.02184078
89Renin secretion_Homo sapiens_hsa049240.01877059
90Protein digestion and absorption_Homo sapiens_hsa049740.01415718
91Pancreatic secretion_Homo sapiens_hsa049720.00752945
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.2008260
93Type II diabetes mellitus_Homo sapiens_hsa04930-0.1954639
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1877077
95Regulation of autophagy_Homo sapiens_hsa04140-0.1800936
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.1691830
97Lysosome_Homo sapiens_hsa04142-0.1612573
98Hepatitis C_Homo sapiens_hsa05160-0.1565499
99Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1383523
100Mineral absorption_Homo sapiens_hsa04978-0.1082596
101Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.1020511
102Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0876128
103Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0840643
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0834022
105Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0802980
106Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0697847
107Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0612017
108Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0554576
109Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0544491
110Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0485302
111Serotonergic synapse_Homo sapiens_hsa04726-0.0162460
112Amoebiasis_Homo sapiens_hsa05146-0.0085249

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