PCM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)5.29237109
2nuclear pore complex assembly (GO:0051292)5.28733982
3nuclear pore organization (GO:0006999)4.93143762
4pre-miRNA processing (GO:0031054)4.09262886
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.08013963
6regulation of RNA export from nucleus (GO:0046831)4.04867113
7regulation of centriole replication (GO:0046599)4.04287981
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.02613831
9* nucleus localization (GO:0051647)3.95272179
10pore complex assembly (GO:0046931)3.93193809
11* interkinetic nuclear migration (GO:0022027)3.66621920
12glucocorticoid receptor signaling pathway (GO:0042921)3.62088257
13cytoplasmic mRNA processing body assembly (GO:0033962)3.53908030
14positive regulation of mitotic sister chromatid separation (GO:1901970)3.52337014
15positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.52337014
16positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.52337014
17regulation of DNA endoreduplication (GO:0032875)3.51581244
18negative regulation of translation, ncRNA-mediated (GO:0040033)3.48880267
19regulation of translation, ncRNA-mediated (GO:0045974)3.48880267
20negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.48880267
21mitotic chromosome condensation (GO:0007076)3.48541391
22cilium movement (GO:0003341)3.46977378
23sister chromatid segregation (GO:0000819)3.45846547
24phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.37011125
25monoubiquitinated protein deubiquitination (GO:0035520)3.36017117
26neural tube formation (GO:0001841)3.32353647
27regulation of sister chromatid cohesion (GO:0007063)3.32087324
28establishment of protein localization to Golgi (GO:0072600)3.30041857
29regulation of nucleobase-containing compound transport (GO:0032239)3.26377757
30negative regulation of histone methylation (GO:0031061)3.25893145
31epithelial cilium movement (GO:0003351)3.23485072
32paraxial mesoderm development (GO:0048339)3.22718272
33negative regulation of DNA repair (GO:0045738)3.22112160
34regulation of histone H3-K9 methylation (GO:0051570)3.18625159
35synapsis (GO:0007129)3.13929941
36regulation of pigment cell differentiation (GO:0050932)3.12126031
37centriole replication (GO:0007099)3.06400746
38* microtubule anchoring (GO:0034453)3.04448398
39sister chromatid cohesion (GO:0007062)3.04400741
40kinetochore organization (GO:0051383)3.03329377
41peptidyl-lysine dimethylation (GO:0018027)2.97263076
42corticosteroid receptor signaling pathway (GO:0031958)2.97090531
43resolution of meiotic recombination intermediates (GO:0000712)2.97024859
44NLS-bearing protein import into nucleus (GO:0006607)2.95645945
45regulation of centrosome duplication (GO:0010824)2.94624484
46gene silencing by RNA (GO:0031047)2.94303161
47protein targeting to Golgi (GO:0000042)2.93770592
48protein localization to kinetochore (GO:0034501)2.88419540
49retrograde transport, vesicle recycling within Golgi (GO:0000301)2.88026541
50histone H3-K9 demethylation (GO:0033169)2.85331413
51dosage compensation (GO:0007549)2.81733959
52axonemal dynein complex assembly (GO:0070286)2.81598674
53mitotic sister chromatid segregation (GO:0000070)2.80669593
54histone H3-K36 demethylation (GO:0070544)2.80466560
55hippo signaling (GO:0035329)2.79788535
56regulation of centrosome cycle (GO:0046605)2.79639025
57mitotic nuclear envelope disassembly (GO:0007077)2.76986857
58peptidyl-lysine methylation (GO:0018022)2.76743764
59piRNA metabolic process (GO:0034587)2.75289187
60positive regulation of chromosome segregation (GO:0051984)2.74465101
61metaphase plate congression (GO:0051310)2.73805546
62histone H3-K9 methylation (GO:0051567)2.73740383
63negative regulation of cytosolic calcium ion concentration (GO:0051481)2.72817433
64regulation of protein polyubiquitination (GO:1902914)2.72084430
65membrane disassembly (GO:0030397)2.71741661
66nuclear envelope disassembly (GO:0051081)2.71741661
67regulation of mitotic spindle organization (GO:0060236)2.66879527
68stress granule assembly (GO:0034063)2.66637209
69regulation of spindle organization (GO:0090224)2.65245224
70dorsal/ventral axis specification (GO:0009950)2.62676533
71mitotic metaphase plate congression (GO:0007080)2.60985579
72DNA geometric change (GO:0032392)2.60983136
73embryonic retina morphogenesis in camera-type eye (GO:0060059)2.59164326
74DNA duplex unwinding (GO:0032508)2.59002884
75male meiosis (GO:0007140)2.57291887
76protein K11-linked deubiquitination (GO:0035871)2.56256030
77DNA unwinding involved in DNA replication (GO:0006268)2.56188087
78microtubule depolymerization (GO:0007019)2.55140564
79* intraciliary transport (GO:0042073)2.54941343
80cerebellar Purkinje cell differentiation (GO:0021702)2.54669237
81meiotic chromosome segregation (GO:0045132)2.53973049
82axoneme assembly (GO:0035082)2.53769630
83histone H2A monoubiquitination (GO:0035518)2.53158686
84myofibril assembly (GO:0030239)2.52746768
85regulation of mitotic metaphase/anaphase transition (GO:0030071)2.52405070
86regulation of sarcomere organization (GO:0060297)2.52080917
87ventricular system development (GO:0021591)2.51755286
88peptidyl-lysine trimethylation (GO:0018023)2.51256962
89gene silencing (GO:0016458)2.51092964
90protein localization to chromosome, centromeric region (GO:0071459)2.51087937
91* cilium organization (GO:0044782)2.49493414
92regulation of sister chromatid segregation (GO:0033045)2.48796896
93regulation of mitotic sister chromatid separation (GO:0010965)2.48796896
94regulation of mitotic sister chromatid segregation (GO:0033047)2.48796896
95protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.48654330
96negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.48649125
97histone H3-K4 trimethylation (GO:0080182)2.48309956
98regulation of chromosome segregation (GO:0051983)2.48207721
99synaptonemal complex assembly (GO:0007130)2.47756413
100regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.46503807
101chromatin assembly (GO:0031497)2.45945519
102rRNA catabolic process (GO:0016075)2.45328787
103cilium or flagellum-dependent cell motility (GO:0001539)2.44931500
104presynaptic membrane assembly (GO:0097105)2.44570284
105* cilium assembly (GO:0042384)2.44412594
106positive regulation of developmental pigmentation (GO:0048087)2.44258520
107translesion synthesis (GO:0019985)2.44147148
108regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.43927621
109histone H2A acetylation (GO:0043968)2.43639754
110heterochromatin organization (GO:0070828)2.43606224
111mRNA stabilization (GO:0048255)2.43191382
112RNA stabilization (GO:0043489)2.43191382
113histone lysine demethylation (GO:0070076)2.42770645
114negative regulation of histone modification (GO:0031057)2.41928564
115establishment of nucleus localization (GO:0040023)2.41854959
116regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.41272619
117DNA packaging (GO:0006323)2.41241966
118regulation of telomere maintenance (GO:0032204)2.40939297
119negative regulation of organelle assembly (GO:1902116)2.40294903
120DNA synthesis involved in DNA repair (GO:0000731)2.39514462
121central nervous system projection neuron axonogenesis (GO:0021952)2.38966403
122spindle assembly checkpoint (GO:0071173)2.38888168
123chromosome condensation (GO:0030261)2.38756267
124histone demethylation (GO:0016577)2.38318367
125spindle checkpoint (GO:0031577)2.37902723
126positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.36717222
127regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.36717222
128gastrulation with mouth forming second (GO:0001702)2.36620161
129olfactory bulb development (GO:0021772)2.36406581
130limb development (GO:0060173)2.36323580
131appendage development (GO:0048736)2.36323580
132histone lysine methylation (GO:0034968)2.36303777
133left/right axis specification (GO:0070986)2.35813096
134* cellular component assembly involved in morphogenesis (GO:0010927)2.34780156
135negative regulation of DNA-dependent DNA replication (GO:2000104)2.34651599
136body morphogenesis (GO:0010171)2.34518033
137non-recombinational repair (GO:0000726)2.34107348
138double-strand break repair via nonhomologous end joining (GO:0006303)2.34107348
139negative regulation of fibroblast apoptotic process (GO:2000270)2.33879626
140attachment of spindle microtubules to kinetochore (GO:0008608)2.33653893
141microtubule polymerization or depolymerization (GO:0031109)2.33611445
142microtubule nucleation (GO:0007020)2.32858367
143DNA topological change (GO:0006265)2.32680162
144heart morphogenesis (GO:0003007)2.32633535
145ATP-dependent chromatin remodeling (GO:0043044)2.32561213
146cerebral cortex radially oriented cell migration (GO:0021799)2.31652409
147otic vesicle formation (GO:0030916)2.31486564
148embryonic foregut morphogenesis (GO:0048617)2.30839800
149protein localization to chromosome (GO:0034502)2.30136060
150negative regulation of neurotransmitter secretion (GO:0046929)2.29819483
151DNA damage induced protein phosphorylation (GO:0006975)2.29585247
152cardiac myofibril assembly (GO:0055003)2.29538717
153mitotic spindle assembly checkpoint (GO:0007094)2.29466845
154adult heart development (GO:0007512)2.29121879
155positive regulation of cell cycle checkpoint (GO:1901978)2.29012166
156mitotic spindle checkpoint (GO:0071174)2.28996574
157histone H3-K9 modification (GO:0061647)2.28775895
158negative regulation of chromatin modification (GO:1903309)2.28571724
159genitalia morphogenesis (GO:0035112)2.27777057
160cerebral cortex development (GO:0021987)2.27369747
161Golgi to endosome transport (GO:0006895)2.27158098
162central nervous system neuron axonogenesis (GO:0021955)2.27110717
163reciprocal DNA recombination (GO:0035825)2.26644045
164reciprocal meiotic recombination (GO:0007131)2.26644045
165negative regulation of DNA recombination (GO:0045910)2.26606875
166histone mRNA catabolic process (GO:0071044)2.25827483
167pancreas development (GO:0031016)2.25433201
168motile cilium assembly (GO:0044458)2.24844017
169coronary vasculature morphogenesis (GO:0060977)2.22908449

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.57443446
2SALL1_21062744_ChIP-ChIP_HESCs_Human4.50862452
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.46110018
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.72684157
5* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.56281141
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.04195121
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.88891483
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.86813949
9IGF1R_20145208_ChIP-Seq_DFB_Human2.58133772
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.50399218
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.44204330
12TAF15_26573619_Chip-Seq_HEK293_Human2.41312334
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.36799551
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35763813
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31597244
16* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.27205736
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.25806144
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.23257286
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.16203816
20* EGR1_19374776_ChIP-ChIP_THP-1_Human2.11773542
21AR_21909140_ChIP-Seq_LNCAP_Human1.96870689
22* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.89179696
23P300_19829295_ChIP-Seq_ESCs_Human1.88050665
24* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.83921625
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.81413410
26FUS_26573619_Chip-Seq_HEK293_Human1.79542809
27FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.78551701
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.73130839
29AR_21572438_ChIP-Seq_LNCaP_Human1.72909463
30VDR_22108803_ChIP-Seq_LS180_Human1.72340479
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70352089
32SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70255349
33DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.70191912
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.68649145
35* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67511773
36PKCTHETA_26484144_Chip-Seq_BREAST_Human1.64426012
37* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.61197290
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.60944241
39TOP2B_26459242_ChIP-Seq_MCF-7_Human1.56349196
40ER_23166858_ChIP-Seq_MCF-7_Human1.55617183
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48218389
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47971280
43EWS_26573619_Chip-Seq_HEK293_Human1.47608299
44NANOG_18555785_Chip-Seq_ESCs_Mouse1.47467528
45CBP_20019798_ChIP-Seq_JUKART_Human1.46552089
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46552089
47EZH2_22144423_ChIP-Seq_EOC_Human1.42246092
48TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.41416760
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.41186795
50ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.41099459
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40629385
52ISL1_27105846_Chip-Seq_CPCs_Mouse1.37651977
53ZNF274_21170338_ChIP-Seq_K562_Hela1.37313951
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37178955
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36573587
56E2F1_18555785_Chip-Seq_ESCs_Mouse1.36495641
57CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.36322599
58* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35349036
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33578195
60AR_25329375_ChIP-Seq_VCAP_Human1.32151713
61EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31737280
62TCF4_18268006_ChIP-ChIP_LS174T_Human1.31369577
63CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30168201
64YAP1_20516196_ChIP-Seq_MESCs_Mouse1.30133822
65* STAT3_23295773_ChIP-Seq_U87_Human1.29512295
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29414759
67EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29349176
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28878660
69TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28841135
70SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28592039
71BCAT_22108803_ChIP-Seq_LS180_Human1.28324123
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28118650
73FLI1_21867929_ChIP-Seq_TH2_Mouse1.27363203
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25702751
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25220086
76CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.24751972
77P53_22387025_ChIP-Seq_ESCs_Mouse1.24056812
78TBX3_20139965_ChIP-Seq_ESCs_Mouse1.23803737
79TBX3_20139965_ChIP-Seq_MESCs_Mouse1.23479729
80RUNX2_22187159_ChIP-Seq_PCA_Human1.22398424
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21863681
82TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.21780777
83* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.20380672
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.19890000
85* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19046246
86ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18473034
87* BRD4_25478319_ChIP-Seq_HGPS_Human1.18343168
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16955154
89CMYC_18555785_Chip-Seq_ESCs_Mouse1.16695298
90RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16544134
91SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15260351
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14618530
93TP53_16413492_ChIP-PET_HCT116_Human1.14537009
94CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13450931
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.13379689
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12708629
97POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.12378380
98LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11134298
99SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10949968
100TCF4_23295773_ChIP-Seq_U87_Human1.10526519
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08909597
102OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08385182
103TCF4_22108803_ChIP-Seq_LS180_Human1.08337161
104WT1_19549856_ChIP-ChIP_CCG9911_Human1.06778074
105* TAL1_26923725_Chip-Seq_HPCs_Mouse1.06581588
106P300_18555785_Chip-Seq_ESCs_Mouse1.06451299
107KDM2B_26808549_Chip-Seq_REH_Human1.04772139
108EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04662072
109SOX9_26525672_Chip-Seq_HEART_Mouse1.03897113
110* SMAD4_21799915_ChIP-Seq_A2780_Human1.03869482
111TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03320233
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00099810
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00099810
114GBX2_23144817_ChIP-Seq_PC3_Human0.99066516
115STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98876314
116POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97843701
117ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97085970
118CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97017989
119SMAD_19615063_ChIP-ChIP_OVARY_Human0.96557731
120AR_19668381_ChIP-Seq_PC3_Human0.95855319
121ARNT_22903824_ChIP-Seq_MCF-7_Human0.95589280
122NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.95461514
123SOX2_16153702_ChIP-ChIP_HESCs_Human0.93852413
124NANOG_21062744_ChIP-ChIP_HESCs_Human0.93823966
125OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91086809
126AHR_22903824_ChIP-Seq_MCF-7_Human0.89806219
127PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89751571
128MYCN_18555785_ChIP-Seq_MESCs_Mouse0.89121983
129PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88491163
130CHD1_26751641_Chip-Seq_LNCaP_Human0.88360926
131MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.87808598
132SOX2_21211035_ChIP-Seq_LN229_Gbm0.87211053
133SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86895427
134PIAS1_25552417_ChIP-Seq_VCAP_Human0.86310419
135TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86108667
136SMAD3_21741376_ChIP-Seq_EPCs_Human0.86096394
137TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.83770282
138STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.83059691
139* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.82948804
140CTBP2_25329375_ChIP-Seq_LNCAP_Human0.82273145
141RNF2_27304074_Chip-Seq_NSC_Mouse0.81955225
142NFIB_24661679_ChIP-Seq_LUNG_Mouse0.81851566
143STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.81564124
144DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81451929
145NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80884327
146ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.78632726
147GF1B_26923725_Chip-Seq_HPCs_Mouse0.78616986
148PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.78445423
149TCF3_18692474_ChIP-Seq_MESCs_Mouse0.78383858
150FOXM1_26456572_ChIP-Seq_MCF-7_Human0.77234037

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.24771876
2MP0003121_genomic_imprinting2.91080496
3MP0008877_abnormal_DNA_methylation2.88764001
4MP0003787_abnormal_imprinting2.63294515
5MP0003123_paternal_imprinting2.46019246
6MP0003890_abnormal_embryonic-extraembry2.37429960
7MP0003122_maternal_imprinting2.24946646
8MP0010094_abnormal_chromosome_stability2.14811848
9MP0004145_abnormal_muscle_electrophysio2.10532821
10MP0000537_abnormal_urethra_morphology2.05831407
11MP0003646_muscle_fatigue2.02651170
12MP0008057_abnormal_DNA_replication2.02458915
13MP0005076_abnormal_cell_differentiation2.00294893
14MP0002653_abnormal_ependyma_morphology1.86423120
15MP0006292_abnormal_olfactory_placode1.79738559
16MP0010352_gastrointestinal_tract_polyps1.74219419
17MP0005623_abnormal_meninges_morphology1.73421189
18MP0010307_abnormal_tumor_latency1.73291965
19MP0010030_abnormal_orbit_morphology1.73250568
20MP0003111_abnormal_nucleus_morphology1.71671983
21MP0004270_analgesia1.71038824
22MP0003937_abnormal_limbs/digits/tail_de1.70999337
23MP0002084_abnormal_developmental_patter1.70134151
24MP0003077_abnormal_cell_cycle1.69250835
25MP0004197_abnormal_fetal_growth/weight/1.59138461
26MP0008007_abnormal_cellular_replicative1.58390294
27MP0002009_preneoplasia1.58056643
28MP0005187_abnormal_penis_morphology1.55871427
29MP0001984_abnormal_olfaction1.53589083
30MP0003935_abnormal_craniofacial_develop1.53351241
31MP0001293_anophthalmia1.50998054
32MP0001299_abnormal_eye_distance/1.50585743
33MP0000383_abnormal_hair_follicle1.49357931
34MP0003385_abnormal_body_wall1.47891731
35MP0002085_abnormal_embryonic_tissue1.47452348
36MP0000428_abnormal_craniofacial_morphol1.44060201
37MP0004084_abnormal_cardiac_muscle1.44023446
38MP0009703_decreased_birth_body1.43067199
39MP0005248_abnormal_Harderian_gland1.42278646
40MP0001730_embryonic_growth_arrest1.39980056
41MP0005380_embryogenesis_phenotype1.39596316
42MP0001672_abnormal_embryogenesis/_devel1.39596316
43MP0003115_abnormal_respiratory_system1.36076455
44MP0003755_abnormal_palate_morphology1.36057808
45MP0009053_abnormal_anal_canal1.34704657
46MP0004215_abnormal_myocardial_fiber1.34466063
47MP0003984_embryonic_growth_retardation1.33806240
48MP0003705_abnormal_hypodermis_morpholog1.33268093
49MP0009046_muscle_twitch1.33036868
50MP0002088_abnormal_embryonic_growth/wei1.32017687
51MP0000733_abnormal_muscle_development1.31997237
52MP0001486_abnormal_startle_reflex1.31931791
53MP0003567_abnormal_fetal_cardiomyocyte1.31823910
54MP0002877_abnormal_melanocyte_morpholog1.31723562
55MP0003880_abnormal_central_pattern1.30272495
56MP0004036_abnormal_muscle_relaxation1.29539098
57MP0001697_abnormal_embryo_size1.28012686
58MP0004957_abnormal_blastocyst_morpholog1.27264865
59MP0002638_abnormal_pupillary_reflex1.26479792
60MP0004233_abnormal_muscle_weight1.26275548
61MP0003119_abnormal_digestive_system1.25530847
62MP0000350_abnormal_cell_proliferation1.24881788
63MP0008058_abnormal_DNA_repair1.24736574
64MP0009780_abnormal_chondrocyte_physiolo1.24720525
65MP0003941_abnormal_skin_development1.23654950
66MP0003942_abnormal_urinary_system1.22413088
67MP0010234_abnormal_vibrissa_follicle1.22271659
68MP0003693_abnormal_embryo_hatching1.22079679
69MP0002938_white_spotting1.21056401
70MP0000432_abnormal_head_morphology1.19469127
71MP0003861_abnormal_nervous_system1.19040353
72MP0004043_abnormal_pH_regulation1.17576773
73MP0002697_abnormal_eye_size1.17358985
74MP0002086_abnormal_extraembryonic_tissu1.17209147
75MP0005174_abnormal_tail_pigmentation1.16946886
76MP0009697_abnormal_copulation1.15883167
77MP0000534_abnormal_ureter_morphology1.15612440
78MP0009672_abnormal_birth_weight1.14815419
79MP0005253_abnormal_eye_physiology1.13710876
80MP0004147_increased_porphyrin_level1.13524907
81MP0000955_abnormal_spinal_cord1.13149751
82MP0003283_abnormal_digestive_organ1.11117268
83MP0002116_abnormal_craniofacial_bone1.10864236
84MP0004133_heterotaxia1.09478993
85MP0002233_abnormal_nose_morphology1.06850970
86MP0002210_abnormal_sex_determination1.06707706
87MP0004130_abnormal_muscle_cell1.06520258
88MP0000049_abnormal_middle_ear1.05518681
89MP0006072_abnormal_retinal_apoptosis1.04888513
90MP0005551_abnormal_eye_electrophysiolog1.04761584
91MP0004924_abnormal_behavior1.03718183
92MP0005386_behavior/neurological_phenoty1.03718183
93MP0000427_abnormal_hair_cycle1.03608608
94MP0008932_abnormal_embryonic_tissue1.03249981
95MP0004264_abnormal_extraembryonic_tissu1.02976287
96MP0001929_abnormal_gametogenesis1.01679464
97MP0006276_abnormal_autonomic_nervous1.01581012
98MP0002925_abnormal_cardiovascular_devel1.01134247
99MP0001849_ear_inflammation1.01012879
100MP0001346_abnormal_lacrimal_gland1.00713484
101MP0000778_abnormal_nervous_system0.99160294
102MP0004808_abnormal_hematopoietic_stem0.98908083
103MP0003656_abnormal_erythrocyte_physiolo0.97882121
104MP0002184_abnormal_innervation0.97490239
105MP0004885_abnormal_endolymph0.96965167
106MP0002067_abnormal_sensory_capabilities0.96669128
107MP0000516_abnormal_urinary_system0.95745128
108MP0005367_renal/urinary_system_phenotyp0.95745128
109MP0008789_abnormal_olfactory_epithelium0.95576119
110MP0000631_abnormal_neuroendocrine_gland0.95108032
111MP0009250_abnormal_appendicular_skeleto0.93688641
112MP0004134_abnormal_chest_morphology0.93213272
113MP0001286_abnormal_eye_development0.93209389
114MP0002092_abnormal_eye_morphology0.93173474
115MP0000566_synostosis0.92687485
116MP0002932_abnormal_joint_morphology0.92263214
117MP0003698_abnormal_male_reproductive0.92022907
118MP0002080_prenatal_lethality0.90747781
119MP0002127_abnormal_cardiovascular_syste0.90135982
120MP0004272_abnormal_basement_membrane0.90083515
121MP0002152_abnormal_brain_morphology0.89968197
122MP0001145_abnormal_male_reproductive0.89751954
123MP0002109_abnormal_limb_morphology0.88286592
124MP0002837_dystrophic_cardiac_calcinosis0.87261110
125MP0001485_abnormal_pinna_reflex0.87214565
126MP0002734_abnormal_mechanical_nocicepti0.86514038
127MP0001188_hyperpigmentation0.85592694
128MP0004742_abnormal_vestibular_system0.84846950
129MP0001177_atelectasis0.84755145
130MP0002063_abnormal_learning/memory/cond0.83913187
131MP0005499_abnormal_olfactory_system0.83592818
132MP0005394_taste/olfaction_phenotype0.83592818
133MP0002272_abnormal_nervous_system0.83458268
134MP0000653_abnormal_sex_gland0.83071616
135MP0002177_abnormal_outer_ear0.83067801
136MP0002114_abnormal_axial_skeleton0.82885075
137MP0005391_vision/eye_phenotype0.82883318
138MP0010678_abnormal_skin_adnexa0.82819669
139MP0005171_absent_coat_pigmentation0.82811570
140MP0002557_abnormal_social/conspecific_i0.82620640
141MP0002234_abnormal_pharynx_morphology0.82424629
142MP0002160_abnormal_reproductive_system0.82174423
143MP0002081_perinatal_lethality0.81884434
144MP0002882_abnormal_neuron_morphology0.81843854
145MP0004811_abnormal_neuron_physiology0.81529768
146MP0003635_abnormal_synaptic_transmissio0.81404681
147MP0005503_abnormal_tendon_morphology0.81226534
148MP0005645_abnormal_hypothalamus_physiol0.80558628
149MP0005409_darkened_coat_color0.79511491
150MP0008775_abnormal_heart_ventricle0.78041189
151MP0003943_abnormal_hepatobiliary_system0.77768288
152MP0002106_abnormal_muscle_physiology0.77424726
153MP0000266_abnormal_heart_morphology0.76262885
154MP0008961_abnormal_basal_metabolism0.74377095
155MP0002102_abnormal_ear_morphology0.74231365
156MP0005646_abnormal_pituitary_gland0.71299175
157MP0002269_muscular_atrophy0.69831572

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.86083785
2Short 4th metacarpal (HP:0010044)3.53265640
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.53265640
4Hyperventilation (HP:0002883)3.27123941
5Chronic hepatic failure (HP:0100626)3.10825986
6Tubulointerstitial nephritis (HP:0001970)2.92242325
7Absent/shortened dynein arms (HP:0200106)2.72894202
8Dynein arm defect of respiratory motile cilia (HP:0012255)2.72894202
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.68346903
10Hyperkalemia (HP:0002153)2.66085228
11Abnormal ciliary motility (HP:0012262)2.62172341
12Nephronophthisis (HP:0000090)2.60904801
13Febrile seizures (HP:0002373)2.60801292
14Increased nuchal translucency (HP:0010880)2.56617466
15Macroorchidism (HP:0000053)2.52981439
16Abnormality of the renal cortex (HP:0011035)2.51915696
17Abnormality of the 4th metacarpal (HP:0010012)2.49797969
18Drooling (HP:0002307)2.49775891
19Abnormality of the astrocytes (HP:0100707)2.49602879
20Astrocytoma (HP:0009592)2.49602879
21Pancreatic fibrosis (HP:0100732)2.48294685
22Abnormality of the renal medulla (HP:0100957)2.47572074
23Abnormality of the fingertips (HP:0001211)2.47116408
24Midline defect of the nose (HP:0004122)2.41889189
25Abnormal respiratory motile cilium physiology (HP:0012261)2.40843391
26Rhinitis (HP:0012384)2.40824632
27Acute myeloid leukemia (HP:0004808)2.37628477
28Medulloblastoma (HP:0002885)2.35687412
29Protruding tongue (HP:0010808)2.33354890
30Abnormal respiratory motile cilium morphology (HP:0005938)2.33254615
31Abnormal respiratory epithelium morphology (HP:0012253)2.33254615
32Molar tooth sign on MRI (HP:0002419)2.31312367
33Abnormality of midbrain morphology (HP:0002418)2.31312367
34Truncal obesity (HP:0001956)2.29883584
35Fair hair (HP:0002286)2.27449010
36Renal duplication (HP:0000075)2.27217358
37* Papillary thyroid carcinoma (HP:0002895)2.25510365
38Long eyelashes (HP:0000527)2.24971623
39Glioma (HP:0009733)2.24647301
40Excessive salivation (HP:0003781)2.23076025
41Pancreatic cysts (HP:0001737)2.21466168
42Obsessive-compulsive behavior (HP:0000722)2.21444745
43Gaze-evoked nystagmus (HP:0000640)2.20852480
44Hypoplastic labia majora (HP:0000059)2.19420058
45Abnormality of the ischium (HP:0003174)2.16623958
46Cystic hygroma (HP:0000476)2.16065537
47Narrow palate (HP:0000189)2.15687429
48Broad-based gait (HP:0002136)2.13591477
49Widely spaced teeth (HP:0000687)2.13566291
50Abnormality of chromosome stability (HP:0003220)2.13404213
51Abnormality of the nasal septum (HP:0000419)2.12369118
52Chromosomal breakage induced by crosslinking agents (HP:0003221)2.09877908
53Hepatoblastoma (HP:0002884)2.08712007
54Postaxial foot polydactyly (HP:0001830)2.07788103
55Urethral obstruction (HP:0000796)2.07638525
56Trigonocephaly (HP:0000243)2.07373866
57Neoplasm of the oral cavity (HP:0100649)2.06945781
58Renovascular hypertension (HP:0100817)2.06697009
59Broad thumb (HP:0011304)2.06352145
60True hermaphroditism (HP:0010459)2.06215875
61Abnormality of the labia minora (HP:0012880)2.05984182
62Hip dysplasia (HP:0001385)2.05783425
63Genital tract atresia (HP:0001827)2.05609947
64Poor coordination (HP:0002370)2.05011929
65Progressive cerebellar ataxia (HP:0002073)2.03584479
66Absent frontal sinuses (HP:0002688)2.03580898
67Renal cortical cysts (HP:0000803)2.02642029
68Intestinal atresia (HP:0011100)2.01893912
69Shallow orbits (HP:0000586)2.01338072
70Ependymoma (HP:0002888)2.00887961
71Heterotopia (HP:0002282)2.00510921
72Medial flaring of the eyebrow (HP:0010747)1.99457400
73Difficulty running (HP:0009046)1.99263914
74Abnormality of the labia majora (HP:0012881)1.96346116
75Ectopic kidney (HP:0000086)1.95161542
76Aplasia/Hypoplasia of the sternum (HP:0006714)1.94818862
77Supernumerary ribs (HP:0005815)1.94187513
78Aplasia/Hypoplasia of the tongue (HP:0010295)1.92844450
79Gait imbalance (HP:0002141)1.91794266
80Cupped ear (HP:0000378)1.91317647
81Skull defect (HP:0001362)1.91125822
82Long clavicles (HP:0000890)1.90588597
83Hyperacusis (HP:0010780)1.89810992
84Deep philtrum (HP:0002002)1.89365353
85Colon cancer (HP:0003003)1.88957081
86Subaortic stenosis (HP:0001682)1.88190063
87Abnormality of the left ventricular outflow tract (HP:0011103)1.88190063
88Vaginal atresia (HP:0000148)1.87747594
89Aqueductal stenosis (HP:0002410)1.87225943
90Subacute progressive viral hepatitis (HP:0006572)1.87097806
91Supernumerary spleens (HP:0009799)1.86513625
92Congenital primary aphakia (HP:0007707)1.86385494
93Deviation of the thumb (HP:0009603)1.86104167
94Abnormality of chromosome segregation (HP:0002916)1.83282521
95Calf muscle hypertrophy (HP:0008981)1.82969798
96Proximal placement of thumb (HP:0009623)1.80920349
97* Thyroid carcinoma (HP:0002890)1.80293518
98Highly arched eyebrow (HP:0002553)1.78358640
99Chromsome breakage (HP:0040012)1.77578386
100Aplasia/Hypoplasia of the tibia (HP:0005772)1.77112694
101Broad phalanges of the hand (HP:0009768)1.76966991
102Elfin facies (HP:0004428)1.76713580
103Degeneration of the lateral corticospinal tracts (HP:0002314)1.74945989
104Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.74945989
105Abnormality of the corticospinal tract (HP:0002492)1.73888717
106Nephrogenic diabetes insipidus (HP:0009806)1.73518009
107Absent speech (HP:0001344)1.73327600
108Tented upper lip vermilion (HP:0010804)1.72975988
109Sloping forehead (HP:0000340)1.72743571
110Shawl scrotum (HP:0000049)1.72451691
111Microglossia (HP:0000171)1.72254402
112Facial hemangioma (HP:0000329)1.72124299
113Muscle hypertrophy of the lower extremities (HP:0008968)1.71905693
114Bowel diverticulosis (HP:0005222)1.71805265
115Absent eyebrow (HP:0002223)1.71581210
116Nephroblastoma (Wilms tumor) (HP:0002667)1.71334106
117Postaxial hand polydactyly (HP:0001162)1.70420977
118Atonic seizures (HP:0010819)1.70397764
119Rimmed vacuoles (HP:0003805)1.70394954
120Neoplasm of the adrenal cortex (HP:0100641)1.69921753
121Exotropia (HP:0000577)1.68914827
122Abnormality of the diencephalon (HP:0010662)1.68378117
123Narrow forehead (HP:0000341)1.68191385
124Hypoplasia of the maxilla (HP:0000327)1.68073894
125Aplasia/Hypoplasia of the uvula (HP:0010293)1.67417324
126Prominent nose (HP:0000448)1.67302035
127Broad finger (HP:0001500)1.66602732
128Blue irides (HP:0000635)1.66266826
129Proximal amyotrophy (HP:0007126)1.66143836
130Tubulointerstitial abnormality (HP:0001969)1.65895329
131Malignant gastrointestinal tract tumors (HP:0006749)1.65824170
132Gastrointestinal carcinoma (HP:0002672)1.65824170
133Submucous cleft hard palate (HP:0000176)1.65497815
134Abnormality of the lower motor neuron (HP:0002366)1.65456198
135Sandal gap (HP:0001852)1.64329983
136Neoplasm of striated muscle (HP:0009728)1.64048456
137Supernumerary bones of the axial skeleton (HP:0009144)1.63389393
138Embryonal renal neoplasm (HP:0011794)1.62843927
139Broad palm (HP:0001169)1.62424295
140Rhabdomyosarcoma (HP:0002859)1.61617052
141Biliary tract neoplasm (HP:0100574)1.60150809
142Broad phalanx (HP:0006009)1.59584142
143Hypoplastic ischia (HP:0003175)1.59103424
144Lip pit (HP:0100267)1.57988640
145Genetic anticipation (HP:0003743)1.56866620
146Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.56044479
147Low anterior hairline (HP:0000294)1.55793009
148Smooth philtrum (HP:0000319)1.55520000
149Thick eyebrow (HP:0000574)1.55481166
150Bell-shaped thorax (HP:0001591)1.55414203
151Overriding aorta (HP:0002623)1.54754449
152Cutaneous finger syndactyly (HP:0010554)1.54136203
153Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.53501841
154Oligodactyly (HP:0012165)1.53392225
155Transitional cell carcinoma of the bladder (HP:0006740)1.53235151
156Abnormality of the distal phalanx of the thumb (HP:0009617)1.52879932
157Anal stenosis (HP:0002025)1.52725463
158Insidious onset (HP:0003587)1.51715577
159Termporal pattern (HP:0011008)1.51715577
160Vesicoureteral reflux (HP:0000076)1.51410562
161Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.50806182
162Broad long bones (HP:0005622)1.50362737
163Oligodactyly (hands) (HP:0001180)1.48994222
164Selective tooth agenesis (HP:0001592)1.48691670
165Bifid tongue (HP:0010297)1.47898044
166Missing ribs (HP:0000921)1.47628691
167Hypopigmentation of the fundus (HP:0007894)1.47367970
168Dislocated radial head (HP:0003083)1.46762366
169Dental malocclusion (HP:0000689)1.46647385
170Sacral dimple (HP:0000960)1.46323359
171Pelvic girdle muscle weakness (HP:0003749)1.45595320
172Abnormality of the carotid arteries (HP:0005344)1.45494876
173Hypospadias (HP:0000047)1.45212173

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.28261361
2CDC73.72736456
3LATS13.33925227
4OBSCN2.73167874
5CASK2.60337808
6BRD42.58970356
7TNIK2.13581818
8PRKD32.09675616
9NEK21.98902933
10CAMK1G1.97509357
11PNCK1.93635564
12ERBB31.93549886
13NEK11.84059466
14CAMK1D1.74089278
15MKNK11.68519781
16STK31.62002033
17FRK1.57304401
18PASK1.56950464
19BMPR1B1.54969166
20SRPK11.54684956
21PLK31.50247411
22MAPK131.50151731
23ATR1.50131241
24MKNK21.39268385
25PDK31.37048047
26PDK41.37048047
27TTK1.36246228
28PDGFRA1.34162091
29NUAK11.33411837
30DMPK1.31902416
31NTRK31.31877890
32CHEK11.30866689
33MAP3K41.30801085
34RIPK11.30721254
35PLK41.27701610
36MTOR1.27507514
37SCYL21.26785179
38ATM1.26485621
39NLK1.26381025
40MAP4K21.24917779
41FGFR21.24322999
42AKT31.20293425
43CHEK21.19944936
44ACVR1B1.16938670
45CDK61.13926923
46ICK1.11560341
47CCNB11.11253703
48WNK31.09490226
49STK391.09487073
50PLK21.07464961
51WNK11.06776592
52EIF2AK31.06082801
53BRSK21.04892199
54FGFR11.02740814
55PKN20.98778956
56SGK20.97325127
57PTK60.95839537
58MAP2K70.94344031
59MAP3K70.93376368
60NTRK20.92905726
61PLK10.92767881
62CSNK1A1L0.92492194
63LATS20.92102734
64PIK3CA0.91689517
65KSR10.91064743
66NEK90.90635169
67CDK20.89394510
68DDR20.88146443
69SGK30.88025682
70TAF10.87279021
71CDK10.86282553
72DYRK1A0.85894087
73ALK0.83735529
74PAK30.83695175
75EPHA40.83440878
76TRPM70.82789183
77AURKB0.81809657
78MELK0.81065774
79CDC42BPA0.78505008
80PDGFRB0.78335537
81PDK20.77202653
82MAP3K100.77086856
83EEF2K0.76373206
84TYRO30.75944233
85MAP2K40.75714269
86STK38L0.75650210
87PRKDC0.75426411
88TEC0.74667743
89CSNK1D0.72895028
90SIK20.72610556
91CDK30.70636885
92FGFR30.70387505
93CDK90.69915628
94MAPK140.67838860
95STK110.66507786
96CDK70.66208740
97PRKAA20.65890626
98CSNK1E0.65406132
99MARK10.64982869
100ZAK0.64976928
101WEE10.64164214
102TSSK60.63822531
103GSK3B0.62712982
104MAPK100.62352901
105CAMK40.62122751
106PIK3CG0.60713168
107OXSR10.60574974
108RET0.60237387
109TTN0.58684835
110MAPK150.57482269
111FER0.57342534
112ERBB20.53854402
113PTK20.53810045
114BCR0.52692362
115PHKG20.52343632
116PHKG10.52343632
117BRSK10.52187629
118STK40.51977478
119AKT10.51956294
120SGK10.50356368
121YES10.49916637
122CSNK1G20.49654028
123CDK40.49235863
124NEK60.48946804
125PRKACB0.48687252
126RPS6KA30.48549006
127MAP3K20.48381676
128TGFBR10.48238041
129SGK2230.47934727
130SGK4940.47934727
131MAPK80.46499636
132CSNK1G10.45732867
133CAMKK20.45287341
134RPS6KB10.45015168
135PAK20.44676989
136EPHB20.44631114
137MET0.41029784
138INSRR0.40538616
139MAPK10.40413106
140PRKAA10.38397944

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.18677211
2mRNA surveillance pathway_Homo sapiens_hsa030152.00939474
3Adherens junction_Homo sapiens_hsa045201.79442136
4RNA transport_Homo sapiens_hsa030131.78973869
5Propanoate metabolism_Homo sapiens_hsa006401.78676182
6Basal cell carcinoma_Homo sapiens_hsa052171.77420958
7Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.76939715
8Nicotine addiction_Homo sapiens_hsa050331.76914041
9Oocyte meiosis_Homo sapiens_hsa041141.63334171
10MicroRNAs in cancer_Homo sapiens_hsa052061.62487668
11Hippo signaling pathway_Homo sapiens_hsa043901.61344422
12Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.59785917
13Dorso-ventral axis formation_Homo sapiens_hsa043201.55432958
14Fanconi anemia pathway_Homo sapiens_hsa034601.54423016
15Lysine degradation_Homo sapiens_hsa003101.48696102
16Taste transduction_Homo sapiens_hsa047421.46413575
17mTOR signaling pathway_Homo sapiens_hsa041501.46186518
18Endometrial cancer_Homo sapiens_hsa052131.44127011
19Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.43342852
20Hedgehog signaling pathway_Homo sapiens_hsa043401.41657042
21Colorectal cancer_Homo sapiens_hsa052101.39181344
22Thyroid hormone signaling pathway_Homo sapiens_hsa049191.37304744
23TGF-beta signaling pathway_Homo sapiens_hsa043501.36521401
24Wnt signaling pathway_Homo sapiens_hsa043101.36279939
25Prostate cancer_Homo sapiens_hsa052151.27596455
26Mismatch repair_Homo sapiens_hsa034301.26176863
27Non-homologous end-joining_Homo sapiens_hsa034501.25552725
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24045446
29Spliceosome_Homo sapiens_hsa030401.20792585
30RNA degradation_Homo sapiens_hsa030181.17907938
31Type II diabetes mellitus_Homo sapiens_hsa049301.17172573
32Chronic myeloid leukemia_Homo sapiens_hsa052201.15805270
33Proteoglycans in cancer_Homo sapiens_hsa052051.15639296
34Glutamatergic synapse_Homo sapiens_hsa047241.15360430
35Small cell lung cancer_Homo sapiens_hsa052221.13215271
36Basal transcription factors_Homo sapiens_hsa030221.12908744
37Inositol phosphate metabolism_Homo sapiens_hsa005621.12686749
38Glioma_Homo sapiens_hsa052141.12552868
39Long-term potentiation_Homo sapiens_hsa047201.12320425
40Butanoate metabolism_Homo sapiens_hsa006501.11770286
41Axon guidance_Homo sapiens_hsa043601.08946220
42Thyroid cancer_Homo sapiens_hsa052161.08192353
43Tight junction_Homo sapiens_hsa045301.07984612
44Alcoholism_Homo sapiens_hsa050341.07661109
45Focal adhesion_Homo sapiens_hsa045101.07305452
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.07125483
47ABC transporters_Homo sapiens_hsa020101.04021997
48Viral carcinogenesis_Homo sapiens_hsa052031.02837055
49Estrogen signaling pathway_Homo sapiens_hsa049151.02728666
50Melanogenesis_Homo sapiens_hsa049161.01466001
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.01191070
52Calcium signaling pathway_Homo sapiens_hsa040200.99613861
53Notch signaling pathway_Homo sapiens_hsa043300.99612991
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.98679271
55Glucagon signaling pathway_Homo sapiens_hsa049220.97346054
56HTLV-I infection_Homo sapiens_hsa051660.96847101
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96805365
58Salivary secretion_Homo sapiens_hsa049700.95318536
59Olfactory transduction_Homo sapiens_hsa047400.95019413
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.93443475
61FoxO signaling pathway_Homo sapiens_hsa040680.92831894
62Systemic lupus erythematosus_Homo sapiens_hsa053220.91383758
63DNA replication_Homo sapiens_hsa030300.91310052
64Pathways in cancer_Homo sapiens_hsa052000.90668264
65Pancreatic cancer_Homo sapiens_hsa052120.90604149
66ErbB signaling pathway_Homo sapiens_hsa040120.90431059
67Non-small cell lung cancer_Homo sapiens_hsa052230.90219818
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89824778
69Homologous recombination_Homo sapiens_hsa034400.89627190
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89429888
71Insulin secretion_Homo sapiens_hsa049110.89311811
72Renal cell carcinoma_Homo sapiens_hsa052110.88171584
73Circadian rhythm_Homo sapiens_hsa047100.87887007
74Dilated cardiomyopathy_Homo sapiens_hsa054140.87320180
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.87221360
76p53 signaling pathway_Homo sapiens_hsa041150.87117765
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86428289
78Phototransduction_Homo sapiens_hsa047440.86167841
79ECM-receptor interaction_Homo sapiens_hsa045120.85586526
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85206780
81Dopaminergic synapse_Homo sapiens_hsa047280.85098550
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84861835
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.81986903
84Prolactin signaling pathway_Homo sapiens_hsa049170.81839096
85Amphetamine addiction_Homo sapiens_hsa050310.81788980
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79958502
87Gap junction_Homo sapiens_hsa045400.79807302
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79512669
89Melanoma_Homo sapiens_hsa052180.79363556
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78713318
91Viral myocarditis_Homo sapiens_hsa054160.78322134
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77981853
93Nucleotide excision repair_Homo sapiens_hsa034200.76372054
94GABAergic synapse_Homo sapiens_hsa047270.76294558
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74035253
96Circadian entrainment_Homo sapiens_hsa047130.72004910
97AMPK signaling pathway_Homo sapiens_hsa041520.71462563
98Regulation of autophagy_Homo sapiens_hsa041400.71455641
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.71427207
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70896773
101Insulin signaling pathway_Homo sapiens_hsa049100.69639094
102Renin secretion_Homo sapiens_hsa049240.68997211
103Choline metabolism in cancer_Homo sapiens_hsa052310.67990923
104MAPK signaling pathway_Homo sapiens_hsa040100.67530760
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66387255
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.65968205
107Morphine addiction_Homo sapiens_hsa050320.65820086
108Thyroid hormone synthesis_Homo sapiens_hsa049180.65434740
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64789746
110cAMP signaling pathway_Homo sapiens_hsa040240.64621347
111Serotonergic synapse_Homo sapiens_hsa047260.64445058
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64380985
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64377915
114Pancreatic secretion_Homo sapiens_hsa049720.64276764
115Ether lipid metabolism_Homo sapiens_hsa005650.64122663
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64106970
117Oxytocin signaling pathway_Homo sapiens_hsa049210.63942770
118Cholinergic synapse_Homo sapiens_hsa047250.63010789
119Rap1 signaling pathway_Homo sapiens_hsa040150.62992126
120Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62491433
121Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62006272
122Long-term depression_Homo sapiens_hsa047300.61526069
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61338123
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61036735
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60788072
126Insulin resistance_Homo sapiens_hsa049310.60381689
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60127561
128Gastric acid secretion_Homo sapiens_hsa049710.60089198
129GnRH signaling pathway_Homo sapiens_hsa049120.59656619
130Cocaine addiction_Homo sapiens_hsa050300.59411090
131Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59388172

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