Rank | Gene Set | Z-score |
---|---|---|
1 | synaptic vesicle exocytosis (GO:0016079) | 5.12639934 |
2 | proteasome assembly (GO:0043248) | 4.99032108 |
3 | neuronal action potential propagation (GO:0019227) | 4.83970090 |
4 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 4.80863811 |
5 | glutamate secretion (GO:0014047) | 4.67162759 |
6 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.47981952 |
7 | protein deneddylation (GO:0000338) | 4.35024649 |
8 | neuron cell-cell adhesion (GO:0007158) | 4.21715268 |
9 | protein localization to synapse (GO:0035418) | 4.19816065 |
10 | regulation of synaptic vesicle transport (GO:1902803) | 4.13178177 |
11 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.07707541 |
12 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.07597545 |
13 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.05515701 |
14 | vocalization behavior (GO:0071625) | 4.01725677 |
15 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.97453850 |
16 | synaptic vesicle maturation (GO:0016188) | 3.95099069 |
17 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 3.93628452 |
18 | ATP hydrolysis coupled proton transport (GO:0015991) | 3.93628452 |
19 | neurotransmitter secretion (GO:0007269) | 3.83751668 |
20 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 3.80941969 |
21 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.69386681 |
22 | ATP synthesis coupled proton transport (GO:0015986) | 3.64061479 |
23 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.64061479 |
24 | chaperone-mediated protein transport (GO:0072321) | 3.62337771 |
25 | transferrin transport (GO:0033572) | 3.62164558 |
26 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 3.62151946 |
27 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.59260956 |
28 | negative regulation of dendrite morphogenesis (GO:0050774) | 3.57569184 |
29 | presynaptic membrane organization (GO:0097090) | 3.56642015 |
30 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.55228054 |
31 | respiratory electron transport chain (GO:0022904) | 3.51187447 |
32 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.50821639 |
33 | neuron-neuron synaptic transmission (GO:0007270) | 3.50702557 |
34 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.46405502 |
35 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.46078523 |
36 | electron transport chain (GO:0022900) | 3.45475686 |
37 | synaptic transmission, glutamatergic (GO:0035249) | 3.41097079 |
38 | presynaptic membrane assembly (GO:0097105) | 3.38017766 |
39 | neurotransmitter transport (GO:0006836) | 3.36727515 |
40 | oxidative phosphorylation (GO:0006119) | 3.36142104 |
41 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.34943755 |
42 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.33673424 |
43 | calcium ion-dependent exocytosis (GO:0017156) | 3.33556960 |
44 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.32652941 |
45 | ferric iron transport (GO:0015682) | 3.31397710 |
46 | trivalent inorganic cation transport (GO:0072512) | 3.31397710 |
47 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.30205211 |
48 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.29266756 |
49 | respiratory chain complex IV assembly (GO:0008535) | 3.28894539 |
50 | locomotory exploration behavior (GO:0035641) | 3.25876753 |
51 | protein targeting to mitochondrion (GO:0006626) | 3.23639352 |
52 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.22863563 |
53 | neuromuscular process controlling posture (GO:0050884) | 3.21834072 |
54 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.20149969 |
55 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.19213882 |
56 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.19037453 |
57 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.18451015 |
58 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.18442029 |
59 | glutamate receptor signaling pathway (GO:0007215) | 3.15517751 |
60 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.13274659 |
61 | negative regulation of ligase activity (GO:0051352) | 3.13274659 |
62 | regulation of neurotransmitter secretion (GO:0046928) | 3.12849246 |
63 | neurotransmitter uptake (GO:0001504) | 3.11514541 |
64 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.10884883 |
65 | protein complex biogenesis (GO:0070271) | 3.10865302 |
66 | protein localization to mitochondrion (GO:0070585) | 3.10806736 |
67 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.10007115 |
68 | proline transport (GO:0015824) | 3.08859145 |
69 | regulation of neurotransmitter levels (GO:0001505) | 3.06150654 |
70 | exploration behavior (GO:0035640) | 3.06114830 |
71 | detection of calcium ion (GO:0005513) | 3.04346975 |
72 | membrane depolarization during action potential (GO:0086010) | 3.04112471 |
73 | termination of RNA polymerase III transcription (GO:0006386) | 3.04035642 |
74 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.04035642 |
75 | DNA double-strand break processing (GO:0000729) | 3.03581648 |
76 | negative regulation of microtubule polymerization (GO:0031115) | 3.03046425 |
77 | regulation of mitochondrial translation (GO:0070129) | 3.02534290 |
78 | positive regulation of mitochondrial fission (GO:0090141) | 3.02527184 |
79 | establishment of protein localization to mitochondrion (GO:0072655) | 3.02124130 |
80 | regulation of synapse structural plasticity (GO:0051823) | 2.99495767 |
81 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 2.98306847 |
82 | calcium-mediated signaling using intracellular calcium source (GO:0035584) | 2.96333370 |
83 | positive regulation of ligase activity (GO:0051351) | 2.94366193 |
84 | regulation of neurotransmitter transport (GO:0051588) | 2.94071547 |
85 | long-term synaptic potentiation (GO:0060291) | 2.93838311 |
86 | regulation of protein kinase A signaling (GO:0010738) | 2.92592479 |
87 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 2.92353421 |
88 | CENP-A containing nucleosome assembly (GO:0034080) | 2.88720849 |
89 | negative regulation of cation channel activity (GO:2001258) | 2.88608093 |
90 | positive regulation of neurotransmitter transport (GO:0051590) | 2.88396510 |
91 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.87839738 |
92 | protein-cofactor linkage (GO:0018065) | 2.87694939 |
93 | regulation of postsynaptic membrane potential (GO:0060078) | 2.87486386 |
94 | protein neddylation (GO:0045116) | 2.87102882 |
95 | deoxyribose phosphate biosynthetic process (GO:0046385) | 2.86934027 |
96 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 2.86934027 |
97 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.85516902 |
98 | positive regulation of membrane potential (GO:0045838) | 2.85041259 |
99 | regulation of glutamate secretion (GO:0014048) | 2.83788212 |
100 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.83210493 |
101 | amino acid salvage (GO:0043102) | 2.82039773 |
102 | L-methionine salvage (GO:0071267) | 2.82039773 |
103 | L-methionine biosynthetic process (GO:0071265) | 2.82039773 |
104 | regulation of vesicle fusion (GO:0031338) | 2.81591384 |
105 | chromatin remodeling at centromere (GO:0031055) | 2.81439339 |
106 | cullin deneddylation (GO:0010388) | 2.81282777 |
107 | neuromuscular synaptic transmission (GO:0007274) | 2.80996404 |
108 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.80281900 |
109 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.80281900 |
110 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.80281900 |
111 | establishment of synaptic vesicle localization (GO:0097480) | 2.79987259 |
112 | synaptic vesicle transport (GO:0048489) | 2.79987259 |
113 | DNA damage response, detection of DNA damage (GO:0042769) | 2.79856795 |
114 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 2.79818003 |
115 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.79579879 |
116 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.79579879 |
117 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.79506085 |
118 | NADH dehydrogenase complex assembly (GO:0010257) | 2.79506085 |
119 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.79506085 |
120 | negative regulation of dendrite development (GO:2000171) | 2.79393868 |
121 | negative regulation of heart rate (GO:0010459) | 2.78329492 |
122 | synaptic vesicle endocytosis (GO:0048488) | 2.78094592 |
123 | ribonucleoprotein complex disassembly (GO:0032988) | 2.77573177 |
124 | ATP biosynthetic process (GO:0006754) | 2.77286767 |
125 | regulation of cell communication by electrical coupling (GO:0010649) | 2.77279543 |
126 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.76721334 |
127 | organelle disassembly (GO:1903008) | 2.76017984 |
128 | protein localization to cilium (GO:0061512) | 2.74945647 |
129 | hydrogen ion transmembrane transport (GO:1902600) | 2.74672930 |
130 | NADH metabolic process (GO:0006734) | 2.74546880 |
131 | membrane depolarization (GO:0051899) | 2.74241491 |
132 | de novo protein folding (GO:0006458) | 2.74117750 |
133 | regulation of voltage-gated calcium channel activity (GO:1901385) | 2.74011166 |
134 | synaptic transmission (GO:0007268) | 2.73841342 |
135 | regulation of synaptic plasticity (GO:0048167) | 2.72728298 |
136 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.72705393 |
137 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 2.72701809 |
138 | activation of protein kinase A activity (GO:0034199) | 2.72574399 |
139 | neuron recognition (GO:0008038) | 2.72225009 |
140 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 2.71496698 |
141 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.69871525 |
142 | deoxyribonucleotide biosynthetic process (GO:0009263) | 2.69098428 |
143 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 2.68904371 |
144 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.68712620 |
145 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.68712620 |
146 | neuronal action potential (GO:0019228) | 2.68051336 |
147 | de novo posttranslational protein folding (GO:0051084) | 2.67011872 |
148 | ribosome assembly (GO:0042255) | 2.66613707 |
149 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.66555915 |
150 | metallo-sulfur cluster assembly (GO:0031163) | 2.66438530 |
151 | iron-sulfur cluster assembly (GO:0016226) | 2.66438530 |
152 | behavioral response to cocaine (GO:0048148) | 2.65920345 |
153 | regulation of ligase activity (GO:0051340) | 2.64974652 |
154 | gamma-aminobutyric acid transport (GO:0015812) | 2.64830470 |
155 | cytochrome complex assembly (GO:0017004) | 2.64552785 |
156 | striatum development (GO:0021756) | 2.64387447 |
157 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.63624245 |
158 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.63417197 |
159 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 2.62281406 |
160 | regulation of coenzyme metabolic process (GO:0051196) | 2.62215481 |
161 | regulation of cofactor metabolic process (GO:0051193) | 2.62215481 |
162 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.61412148 |
163 | regulation of cellular amine metabolic process (GO:0033238) | 2.60698125 |
164 | DNA replication checkpoint (GO:0000076) | 2.56943322 |
165 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.56213447 |
166 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.56213447 |
167 | protein K11-linked ubiquitination (GO:0070979) | 2.54131382 |
168 | mitochondrial transport (GO:0006839) | 2.53436707 |
169 | protein maturation by protein folding (GO:0022417) | 2.53313157 |
170 | spliceosomal snRNP assembly (GO:0000387) | 2.52013792 |
171 | rRNA modification (GO:0000154) | 2.51779362 |
172 | tricarboxylic acid cycle (GO:0006099) | 2.49922768 |
173 | inner mitochondrial membrane organization (GO:0007007) | 2.49164878 |
174 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 2.48721830 |
175 | tRNA aminoacylation for protein translation (GO:0006418) | 2.48664908 |
176 | amino acid activation (GO:0043038) | 2.48099459 |
177 | tRNA aminoacylation (GO:0043039) | 2.48099459 |
178 | histone exchange (GO:0043486) | 2.47573006 |
179 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.47125590 |
Rank | Gene Set | Z-score |
---|---|---|
1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.72016555 |
2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.61027552 |
3 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.85165553 |
4 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.77745118 |
5 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.77639969 |
6 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.75127398 |
7 | * PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.61631965 |
8 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.51282360 |
9 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.50167319 |
10 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.46522017 |
11 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.43695355 |
12 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.38324486 |
13 | * REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.35129503 |
14 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.30592888 |
15 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.27252086 |
16 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.23347183 |
17 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.21550097 |
18 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.19029471 |
19 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 2.17207826 |
20 | VDR_22108803_ChIP-Seq_LS180_Human | 2.16511046 |
21 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.12823254 |
22 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.12679407 |
23 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.11943551 |
24 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.11773033 |
25 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.09670088 |
26 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.09142568 |
27 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.08335430 |
28 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.07771665 |
29 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.04986851 |
30 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.02094792 |
31 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.97835405 |
32 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.97835405 |
33 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.97485456 |
34 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.96721545 |
35 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.96058079 |
36 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.89327171 |
37 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.88701711 |
38 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.88350624 |
39 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.87044978 |
40 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.86114134 |
41 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.80589394 |
42 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.80537058 |
43 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.79833738 |
44 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.79391580 |
45 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.79030403 |
46 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.79010175 |
47 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.77226886 |
48 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.76635530 |
49 | P300_19829295_ChIP-Seq_ESCs_Human | 1.74936753 |
50 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.71459716 |
51 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.68730458 |
52 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.67787022 |
53 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.65207805 |
54 | EWS_26573619_Chip-Seq_HEK293_Human | 1.64763969 |
55 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.62815654 |
56 | * SMAD4_21799915_ChIP-Seq_A2780_Human | 1.62116905 |
57 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.60643543 |
58 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.55313451 |
59 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.55218626 |
60 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.53879920 |
61 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.53466218 |
62 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.51862891 |
63 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.50508830 |
64 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.48448098 |
65 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.46910024 |
66 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.46211756 |
67 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.42925240 |
68 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.42744368 |
69 | * HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.41243683 |
70 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.38498630 |
71 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.37407677 |
72 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.37158316 |
73 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.36152279 |
74 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.35633448 |
75 | FUS_26573619_Chip-Seq_HEK293_Human | 1.33331839 |
76 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.33135574 |
77 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.33082960 |
78 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 1.32465582 |
79 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.31951681 |
80 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.31498144 |
81 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.29039814 |
82 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.28996794 |
83 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.27691063 |
84 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.27437758 |
85 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.27322336 |
86 | * PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.26599912 |
87 | * AR_25329375_ChIP-Seq_VCAP_Human | 1.25257297 |
88 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.25162731 |
89 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.23800072 |
90 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.23627868 |
91 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.22818836 |
92 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.22156833 |
93 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.21227413 |
94 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.21212751 |
95 | JUN_21703547_ChIP-Seq_K562_Human | 1.19977542 |
96 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.19848503 |
97 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.17418479 |
98 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.16814449 |
99 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.16531753 |
100 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.15900903 |
101 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.13199961 |
102 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.13177284 |
103 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.12883555 |
104 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.12872797 |
105 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.11746360 |
106 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.11236236 |
107 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.10908676 |
108 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.10519820 |
109 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.09818408 |
110 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.06877351 |
111 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.06090028 |
112 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.05573901 |
113 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.05370465 |
114 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.02986343 |
115 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.01796151 |
116 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.01414334 |
117 | DROSHA_22980978_ChIP-Seq_HELA_Human | 0.97463114 |
118 | * PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.96205112 |
119 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.95931721 |
120 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.95931721 |
121 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.95327794 |
122 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.95177111 |
123 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.94918025 |
124 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.93683875 |
125 | REST_19997604_ChIP-ChIP_NEURONS_Mouse | 0.93513818 |
126 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 0.92966100 |
127 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.92561944 |
128 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.92465565 |
129 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.92172279 |
130 | * CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.91968166 |
131 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.91264216 |
132 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.90925890 |
133 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.90925890 |
134 | STAT3_23295773_ChIP-Seq_U87_Human | 0.90417258 |
135 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.89770027 |
136 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 0.89670499 |
137 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.88394159 |
138 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.87767759 |
139 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.87480931 |
140 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.86874536 |
141 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 0.86617236 |
142 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.83597606 |
143 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.83531885 |
144 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.82714756 |
145 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.82636853 |
146 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.82424506 |
147 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.82193894 |
148 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.82168863 |
149 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.79948901 |
150 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.79577219 |
151 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.79366905 |
152 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.77851305 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003880_abnormal_central_pattern | 4.69411393 |
2 | MP0004859_abnormal_synaptic_plasticity | 4.49749926 |
3 | MP0001968_abnormal_touch/_nociception | 3.63560408 |
4 | MP0003635_abnormal_synaptic_transmissio | 3.46761814 |
5 | MP0004270_analgesia | 3.33808938 |
6 | MP0002736_abnormal_nociception_after | 3.28210277 |
7 | MP0002735_abnormal_chemical_nociception | 3.22261943 |
8 | * MP0009745_abnormal_behavioral_response | 3.07968444 |
9 | * MP0002064_seizures | 2.94467122 |
10 | * MP0009046_muscle_twitch | 2.88469957 |
11 | MP0002734_abnormal_mechanical_nocicepti | 2.84110900 |
12 | MP0002063_abnormal_learning/memory/cond | 2.71246290 |
13 | * MP0002272_abnormal_nervous_system | 2.67150502 |
14 | MP0006276_abnormal_autonomic_nervous | 2.67053966 |
15 | MP0002102_abnormal_ear_morphology | 2.56171300 |
16 | MP0002572_abnormal_emotion/affect_behav | 2.47947420 |
17 | MP0005423_abnormal_somatic_nervous | 2.41758227 |
18 | MP0001529_abnormal_vocalization | 2.40598334 |
19 | MP0008058_abnormal_DNA_repair | 2.34682531 |
20 | MP0002733_abnormal_thermal_nociception | 2.27724045 |
21 | MP0001970_abnormal_pain_threshold | 2.24931090 |
22 | MP0002822_catalepsy | 2.21911267 |
23 | MP0002067_abnormal_sensory_capabilities | 2.11284142 |
24 | MP0001440_abnormal_grooming_behavior | 2.07333479 |
25 | MP0001905_abnormal_dopamine_level | 2.06197197 |
26 | MP0001501_abnormal_sleep_pattern | 2.05959038 |
27 | MP0001486_abnormal_startle_reflex | 1.97781961 |
28 | MP0010094_abnormal_chromosome_stability | 1.88015026 |
29 | MP0005646_abnormal_pituitary_gland | 1.85709722 |
30 | MP0001986_abnormal_taste_sensitivity | 1.85624121 |
31 | MP0004142_abnormal_muscle_tone | 1.81393042 |
32 | MP0005386_behavior/neurological_phenoty | 1.76418691 |
33 | MP0004924_abnormal_behavior | 1.76418691 |
34 | MP0001984_abnormal_olfaction | 1.74003950 |
35 | MP0002184_abnormal_innervation | 1.70567089 |
36 | MP0003186_abnormal_redox_activity | 1.70249823 |
37 | MP0002837_dystrophic_cardiac_calcinosis | 1.69257616 |
38 | MP0003329_amyloid_beta_deposits | 1.67830563 |
39 | MP0003693_abnormal_embryo_hatching | 1.65593309 |
40 | MP0008932_abnormal_embryonic_tissue | 1.64504007 |
41 | MP0003122_maternal_imprinting | 1.61663406 |
42 | MP0009697_abnormal_copulation | 1.55941851 |
43 | MP0003718_maternal_effect | 1.55768539 |
44 | MP0004147_increased_porphyrin_level | 1.55471323 |
45 | MP0004811_abnormal_neuron_physiology | 1.52893180 |
46 | MP0008569_lethality_at_weaning | 1.51552177 |
47 | MP0004858_abnormal_nervous_system | 1.49355134 |
48 | MP0003879_abnormal_hair_cell | 1.48722681 |
49 | MP0004145_abnormal_muscle_electrophysio | 1.47958612 |
50 | MP0000751_myopathy | 1.46404276 |
51 | MP0002557_abnormal_social/conspecific_i | 1.46286457 |
52 | MP0010386_abnormal_urinary_bladder | 1.46091136 |
53 | MP0005645_abnormal_hypothalamus_physiol | 1.44808517 |
54 | MP0004957_abnormal_blastocyst_morpholog | 1.44499241 |
55 | MP0002234_abnormal_pharynx_morphology | 1.44117590 |
56 | MP0002090_abnormal_vision | 1.42563548 |
57 | MP0003646_muscle_fatigue | 1.39467607 |
58 | MP0001188_hyperpigmentation | 1.36465520 |
59 | MP0005410_abnormal_fertilization | 1.35146441 |
60 | MP0003786_premature_aging | 1.35132204 |
61 | MP0003111_abnormal_nucleus_morphology | 1.34731809 |
62 | MP0003806_abnormal_nucleotide_metabolis | 1.34232095 |
63 | MP0000955_abnormal_spinal_cord | 1.29202275 |
64 | MP0002066_abnormal_motor_capabilities/c | 1.29134558 |
65 | MP0005187_abnormal_penis_morphology | 1.28916967 |
66 | MP0008789_abnormal_olfactory_epithelium | 1.26367258 |
67 | MP0000778_abnormal_nervous_system | 1.25451626 |
68 | * MP0002882_abnormal_neuron_morphology | 1.21946082 |
69 | MP0003121_genomic_imprinting | 1.21815030 |
70 | MP0008872_abnormal_physiological_respon | 1.21448092 |
71 | MP0006072_abnormal_retinal_apoptosis | 1.20362483 |
72 | MP0000358_abnormal_cell_content/ | 1.18802663 |
73 | MP0000013_abnormal_adipose_tissue | 1.18451129 |
74 | MP0002909_abnormal_adrenal_gland | 1.16368156 |
75 | MP0003077_abnormal_cell_cycle | 1.16238990 |
76 | MP0002876_abnormal_thyroid_physiology | 1.15007070 |
77 | MP0008007_abnormal_cellular_replicative | 1.14768798 |
78 | MP0004215_abnormal_myocardial_fiber | 1.14354390 |
79 | MP0003633_abnormal_nervous_system | 1.11402682 |
80 | MP0008995_early_reproductive_senescence | 1.10936359 |
81 | MP0000749_muscle_degeneration | 1.10339229 |
82 | MP0006035_abnormal_mitochondrial_morpho | 1.09059466 |
83 | MP0006036_abnormal_mitochondrial_physio | 1.07278652 |
84 | MP0003787_abnormal_imprinting | 1.04731006 |
85 | MP0003136_yellow_coat_color | 1.04544516 |
86 | MP0004036_abnormal_muscle_relaxation | 1.03609057 |
87 | MP0008877_abnormal_DNA_methylation | 1.02068607 |
88 | MP0005253_abnormal_eye_physiology | 1.00911348 |
89 | MP0005084_abnormal_gallbladder_morpholo | 0.99966684 |
90 | MP0002229_neurodegeneration | 0.99065300 |
91 | MP0009780_abnormal_chondrocyte_physiolo | 0.98143822 |
92 | MP0003631_nervous_system_phenotype | 0.97991586 |
93 | MP0000647_abnormal_sebaceous_gland | 0.96873680 |
94 | MP0000569_abnormal_digit_pigmentation | 0.95718210 |
95 | MP0002638_abnormal_pupillary_reflex | 0.94776079 |
96 | MP0005551_abnormal_eye_electrophysiolog | 0.93412697 |
97 | MP0008260_abnormal_autophagy | 0.93171806 |
98 | MP0002160_abnormal_reproductive_system | 0.92247270 |
99 | MP0001502_abnormal_circadian_rhythm | 0.92201295 |
100 | MP0005535_abnormal_body_temperature | 0.91438485 |
101 | MP0004885_abnormal_endolymph | 0.87925509 |
102 | MP0003656_abnormal_erythrocyte_physiolo | 0.86137381 |
103 | MP0006292_abnormal_olfactory_placode | 0.85813716 |
104 | MP0004742_abnormal_vestibular_system | 0.85297134 |
105 | MP0000631_abnormal_neuroendocrine_gland | 0.85265966 |
106 | MP0001929_abnormal_gametogenesis | 0.84725228 |
107 | MP0000747_muscle_weakness | 0.84572865 |
108 | MP0002210_abnormal_sex_determination | 0.84375017 |
109 | MP0003221_abnormal_cardiomyocyte_apopto | 0.83495142 |
110 | MP0004085_abnormal_heartbeat | 0.83151919 |
111 | MP0005075_abnormal_melanosome_morpholog | 0.82275747 |
112 | MP0003123_paternal_imprinting | 0.82213260 |
113 | MP0001963_abnormal_hearing_physiology | 0.81300467 |
114 | MP0005171_absent_coat_pigmentation | 0.80017246 |
115 | MP0004484_altered_response_of | 0.79876997 |
116 | MP0002069_abnormal_eating/drinking_beha | 0.79377572 |
117 | MP0004043_abnormal_pH_regulation | 0.79246020 |
118 | MP0001664_abnormal_digestion | 0.76865911 |
119 | MP0003567_abnormal_fetal_cardiomyocyte | 0.74675283 |
120 | MP0002752_abnormal_somatic_nervous | 0.74535279 |
121 | MP0001485_abnormal_pinna_reflex | 0.73947415 |
122 | MP0002751_abnormal_autonomic_nervous | 0.73541733 |
123 | * MP0002152_abnormal_brain_morphology | 0.72516190 |
124 | MP0002095_abnormal_skin_pigmentation | 0.71885818 |
125 | MP0003634_abnormal_glial_cell | 0.70056214 |
126 | MP0005394_taste/olfaction_phenotype | 0.67930710 |
127 | MP0005499_abnormal_olfactory_system | 0.67930710 |
128 | MP0003183_abnormal_peptide_metabolism | 0.67521608 |
129 | MP0005620_abnormal_muscle_contractility | 0.66318146 |
130 | MP0000372_irregular_coat_pigmentation | 0.65746944 |
131 | MP0000920_abnormal_myelination | 0.64106225 |
132 | MP0000604_amyloidosis | 0.63260639 |
133 | MP0003698_abnormal_male_reproductive | 0.62602440 |
134 | MP0008874_decreased_physiological_sensi | 0.61393406 |
135 | MP0002163_abnormal_gland_morphology | 0.58735642 |
136 | MP0003632_abnormal_nervous_system | 0.56167612 |
137 | MP0003137_abnormal_impulse_conducting | 0.55621069 |
138 | MP0004233_abnormal_muscle_weight | 0.55538749 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Focal motor seizures (HP:0011153) | 6.34994302 |
2 | Myokymia (HP:0002411) | 5.26332591 |
3 | Atonic seizures (HP:0010819) | 4.61358564 |
4 | Acute necrotizing encephalopathy (HP:0006965) | 4.41192558 |
5 | Focal seizures (HP:0007359) | 4.23435471 |
6 | Pheochromocytoma (HP:0002666) | 4.21568094 |
7 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.21450878 |
8 | Epileptic encephalopathy (HP:0200134) | 4.19109392 |
9 | Neuroendocrine neoplasm (HP:0100634) | 4.13212210 |
10 | Febrile seizures (HP:0002373) | 3.87967691 |
11 | Mitochondrial inheritance (HP:0001427) | 3.85999378 |
12 | Visual hallucinations (HP:0002367) | 3.79904839 |
13 | Progressive macrocephaly (HP:0004481) | 3.76012449 |
14 | Absence seizures (HP:0002121) | 3.58885435 |
15 | Hepatocellular necrosis (HP:0001404) | 3.39422320 |
16 | Increased CSF lactate (HP:0002490) | 3.38599926 |
17 | Dialeptic seizures (HP:0011146) | 3.37042828 |
18 | Acute encephalopathy (HP:0006846) | 3.36661962 |
19 | Generalized tonic-clonic seizures (HP:0002069) | 3.21271690 |
20 | Progressive cerebellar ataxia (HP:0002073) | 3.13701046 |
21 | Hyperventilation (HP:0002883) | 2.96974715 |
22 | Hypothermia (HP:0002045) | 2.96180526 |
23 | 3-Methylglutaconic aciduria (HP:0003535) | 2.87945176 |
24 | Abnormality of the anterior horn cell (HP:0006802) | 2.86374813 |
25 | Degeneration of anterior horn cells (HP:0002398) | 2.86374813 |
26 | Poor suck (HP:0002033) | 2.85455879 |
27 | Limb dystonia (HP:0002451) | 2.79819251 |
28 | Progressive inability to walk (HP:0002505) | 2.77335857 |
29 | Anxiety (HP:0000739) | 2.77188267 |
30 | Retinal dysplasia (HP:0007973) | 2.76572873 |
31 | Increased serum pyruvate (HP:0003542) | 2.74655960 |
32 | Abnormality of glycolysis (HP:0004366) | 2.74655960 |
33 | Ankle clonus (HP:0011448) | 2.74424217 |
34 | Inability to walk (HP:0002540) | 2.71763883 |
35 | Hepatic necrosis (HP:0002605) | 2.64827843 |
36 | Medial flaring of the eyebrow (HP:0010747) | 2.57823090 |
37 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.56403440 |
38 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.56403440 |
39 | Gait imbalance (HP:0002141) | 2.55621060 |
40 | Delusions (HP:0000746) | 2.55548181 |
41 | Abnormal hair whorl (HP:0010721) | 2.51121084 |
42 | Optic disc pallor (HP:0000543) | 2.50125293 |
43 | Truncal ataxia (HP:0002078) | 2.48115892 |
44 | Type I transferrin isoform profile (HP:0003642) | 2.47729870 |
45 | Broad-based gait (HP:0002136) | 2.47510639 |
46 | Hypoglycemic coma (HP:0001325) | 2.45714587 |
47 | Abnormal eating behavior (HP:0100738) | 2.43966982 |
48 | CNS hypomyelination (HP:0003429) | 2.41805217 |
49 | Lactic acidosis (HP:0003128) | 2.41356052 |
50 | Methylmalonic acidemia (HP:0002912) | 2.38643293 |
51 | Congenital primary aphakia (HP:0007707) | 2.36959955 |
52 | Absent/shortened dynein arms (HP:0200106) | 2.36216477 |
53 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.36216477 |
54 | Neoplasm of the peripheral nervous system (HP:0100007) | 2.34039340 |
55 | Polyphagia (HP:0002591) | 2.31629649 |
56 | Gaze-evoked nystagmus (HP:0000640) | 2.31217939 |
57 | Poor eye contact (HP:0000817) | 2.29496435 |
58 | Increased muscle lipid content (HP:0009058) | 2.29127935 |
59 | Abnormality of the labia minora (HP:0012880) | 2.28846949 |
60 | Exercise intolerance (HP:0003546) | 2.28742991 |
61 | Emotional lability (HP:0000712) | 2.27203620 |
62 | Increased hepatocellular lipid droplets (HP:0006565) | 2.26781843 |
63 | Action tremor (HP:0002345) | 2.23862342 |
64 | Increased serum lactate (HP:0002151) | 2.23144625 |
65 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.22881535 |
66 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.22881535 |
67 | Fetal akinesia sequence (HP:0001989) | 2.22476477 |
68 | Supranuclear gaze palsy (HP:0000605) | 2.21079779 |
69 | Respiratory failure (HP:0002878) | 2.19682209 |
70 | Leukodystrophy (HP:0002415) | 2.19658701 |
71 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.19589692 |
72 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.19589692 |
73 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.18494217 |
74 | Oligomenorrhea (HP:0000876) | 2.17581426 |
75 | Hyperglycinemia (HP:0002154) | 2.16039482 |
76 | Generalized aminoaciduria (HP:0002909) | 2.15836571 |
77 | Nephrogenic diabetes insipidus (HP:0009806) | 2.15154567 |
78 | Depression (HP:0000716) | 2.15091269 |
79 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.14927673 |
80 | Abnormality of alanine metabolism (HP:0010916) | 2.14927673 |
81 | Hyperalaninemia (HP:0003348) | 2.14927673 |
82 | CNS demyelination (HP:0007305) | 2.14098669 |
83 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.12523681 |
84 | Abnormal protein glycosylation (HP:0012346) | 2.12523681 |
85 | Abnormal glycosylation (HP:0012345) | 2.12523681 |
86 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.12523681 |
87 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 2.12426544 |
88 | Epileptiform EEG discharges (HP:0011182) | 2.12232779 |
89 | Amblyopia (HP:0000646) | 2.11640034 |
90 | Failure to thrive in infancy (HP:0001531) | 2.09995128 |
91 | Exercise-induced muscle cramps (HP:0003710) | 2.07108388 |
92 | Impaired pain sensation (HP:0007328) | 2.06688601 |
93 | Abnormality of pain sensation (HP:0010832) | 2.06688601 |
94 | Unsteady gait (HP:0002317) | 2.05730370 |
95 | Myotonia (HP:0002486) | 2.05118723 |
96 | Lethargy (HP:0001254) | 2.02616235 |
97 | Type II lissencephaly (HP:0007260) | 2.02093302 |
98 | EEG with generalized epileptiform discharges (HP:0011198) | 1.98474518 |
99 | Methylmalonic aciduria (HP:0012120) | 1.98248966 |
100 | Abnormal gallbladder physiology (HP:0012438) | 1.97999072 |
101 | Cholecystitis (HP:0001082) | 1.97999072 |
102 | Reduced antithrombin III activity (HP:0001976) | 1.97524270 |
103 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.97365695 |
104 | Muscular hypotonia of the trunk (HP:0008936) | 1.96754519 |
105 | Microvesicular hepatic steatosis (HP:0001414) | 1.96519251 |
106 | Increased intramyocellular lipid droplets (HP:0012240) | 1.95993372 |
107 | Urinary urgency (HP:0000012) | 1.94951045 |
108 | Renal cortical cysts (HP:0000803) | 1.94937244 |
109 | Cerebral hypomyelination (HP:0006808) | 1.94904872 |
110 | Hypoventilation (HP:0002791) | 1.94844354 |
111 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.93439739 |
112 | Bradykinesia (HP:0002067) | 1.93430065 |
113 | Abnormal ciliary motility (HP:0012262) | 1.92660332 |
114 | Abnormality of the corticospinal tract (HP:0002492) | 1.91375930 |
115 | Abnormality of serum amino acid levels (HP:0003112) | 1.91365692 |
116 | Exertional dyspnea (HP:0002875) | 1.91099452 |
117 | Spastic gait (HP:0002064) | 1.90938935 |
118 | Palpitations (HP:0001962) | 1.89460226 |
119 | Genital tract atresia (HP:0001827) | 1.88398066 |
120 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 1.87863664 |
121 | Esotropia (HP:0000565) | 1.86282428 |
122 | Mutism (HP:0002300) | 1.85801130 |
123 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.84999265 |
124 | X-linked dominant inheritance (HP:0001423) | 1.84949890 |
125 | Hypsarrhythmia (HP:0002521) | 1.84410701 |
126 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.84145363 |
127 | Cerebral edema (HP:0002181) | 1.84139120 |
128 | Lipid accumulation in hepatocytes (HP:0006561) | 1.82332894 |
129 | Rhinitis (HP:0012384) | 1.81202078 |
130 | Renal Fanconi syndrome (HP:0001994) | 1.81134857 |
131 | Postnatal microcephaly (HP:0005484) | 1.79758156 |
132 | Vaginal atresia (HP:0000148) | 1.79609729 |
133 | Impaired social interactions (HP:0000735) | 1.79220888 |
134 | Abnormal social behavior (HP:0012433) | 1.79220888 |
135 | Progressive microcephaly (HP:0000253) | 1.77728652 |
136 | Nausea (HP:0002018) | 1.74525102 |
137 | Abnormality of urine glucose concentration (HP:0011016) | 1.73686026 |
138 | Glycosuria (HP:0003076) | 1.73686026 |
139 | Shoulder girdle muscle weakness (HP:0003547) | 1.70275862 |
140 | Cortical dysplasia (HP:0002539) | 1.69114536 |
141 | Respiratory difficulties (HP:0002880) | 1.66114004 |
142 | Neoplasm of the adrenal gland (HP:0100631) | 1.62669549 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MAP3K12 | 3.85350336 |
2 | NTRK3 | 3.61913773 |
3 | MAP2K7 | 3.60675041 |
4 | MAP3K4 | 3.43800718 |
5 | CASK | 3.39837945 |
6 | TRIM28 | 3.34750924 |
7 | MINK1 | 2.60971239 |
8 | ARAF | 2.59902216 |
9 | SRPK1 | 2.44274097 |
10 | MAP2K4 | 2.31232911 |
11 | MAP4K2 | 2.31108655 |
12 | MAP3K9 | 2.18631374 |
13 | CCNB1 | 2.14875892 |
14 | NME1 | 2.11414206 |
15 | EPHA4 | 1.99286239 |
16 | PLK2 | 1.97535605 |
17 | MARK1 | 1.93007227 |
18 | CDK19 | 1.91262674 |
19 | PBK | 1.86215195 |
20 | GRK5 | 1.84101858 |
21 | EIF2AK3 | 1.75469752 |
22 | PDK4 | 1.75233754 |
23 | PDK3 | 1.75233754 |
24 | BCKDK | 1.73257327 |
25 | MST4 | 1.70738550 |
26 | DAPK2 | 1.70332363 |
27 | RIPK4 | 1.66784323 |
28 | PNCK | 1.65929101 |
29 | DAPK1 | 1.64055435 |
30 | PLK4 | 1.57838238 |
31 | CAMKK2 | 1.54320821 |
32 | CSNK1G1 | 1.40230042 |
33 | NTRK1 | 1.38597953 |
34 | MAPK13 | 1.37257395 |
35 | CSNK1A1L | 1.30906648 |
36 | PRKCG | 1.27424798 |
37 | KSR2 | 1.24347962 |
38 | BUB1 | 1.23571585 |
39 | WEE1 | 1.21866590 |
40 | STK16 | 1.21220053 |
41 | TTK | 1.20443399 |
42 | BMPR1B | 1.18285791 |
43 | OXSR1 | 1.15890024 |
44 | LIMK1 | 1.15616424 |
45 | ZAK | 1.10419758 |
46 | DYRK2 | 1.10335212 |
47 | PINK1 | 1.09697017 |
48 | BMPR2 | 1.07305196 |
49 | TSSK6 | 1.06870512 |
50 | BRAF | 1.06320800 |
51 | NEK1 | 1.05968516 |
52 | CDK5 | 1.05275823 |
53 | PHKG2 | 1.03582770 |
54 | PHKG1 | 1.03582770 |
55 | PLK1 | 1.02085578 |
56 | CAMK2A | 1.01914725 |
57 | EIF2AK1 | 1.01333926 |
58 | CDC7 | 0.99744127 |
59 | UHMK1 | 0.98785004 |
60 | SIK3 | 0.97806296 |
61 | RPS6KA4 | 0.96493450 |
62 | NUAK1 | 0.95726713 |
63 | CDK14 | 0.94567563 |
64 | CAMKK1 | 0.93639931 |
65 | PTK2B | 0.92324978 |
66 | NTRK2 | 0.91722156 |
67 | CDK18 | 0.89101880 |
68 | PDK2 | 0.87331758 |
69 | MYLK | 0.87028558 |
70 | SGK494 | 0.85326070 |
71 | SGK223 | 0.85326070 |
72 | MAPKAPK5 | 0.85119279 |
73 | PAK6 | 0.84056808 |
74 | PRPF4B | 0.84042447 |
75 | KSR1 | 0.83208112 |
76 | CAMK2G | 0.82793366 |
77 | CAMK2B | 0.82096988 |
78 | CSNK1G2 | 0.81594485 |
79 | CDK15 | 0.81154138 |
80 | FRK | 0.80549171 |
81 | NME2 | 0.80530273 |
82 | AKT3 | 0.78299836 |
83 | BRSK1 | 0.78082081 |
84 | BCR | 0.76937103 |
85 | GRK7 | 0.75407297 |
86 | PRKD3 | 0.74214655 |
87 | TESK1 | 0.72847322 |
88 | MAP3K2 | 0.71293504 |
89 | STK39 | 0.69888458 |
90 | VRK2 | 0.69752452 |
91 | CDK11A | 0.69420260 |
92 | BRSK2 | 0.68666911 |
93 | OBSCN | 0.68601443 |
94 | CSNK1G3 | 0.68366011 |
95 | PRKCE | 0.67445753 |
96 | FES | 0.66310150 |
97 | RAF1 | 0.65532637 |
98 | SCYL2 | 0.62683738 |
99 | TNIK | 0.62320931 |
100 | ADRBK1 | 0.62062164 |
101 | CAMK2D | 0.60260921 |
102 | TESK2 | 0.59308120 |
103 | ADRBK2 | 0.59274960 |
104 | INSRR | 0.58211334 |
105 | LMTK2 | 0.57430406 |
106 | WNK4 | 0.56809380 |
107 | MAP3K5 | 0.56606669 |
108 | SGK2 | 0.56120940 |
109 | MUSK | 0.55152823 |
110 | DYRK3 | 0.54058703 |
111 | PLK3 | 0.53488826 |
112 | WNK3 | 0.52563831 |
113 | CAMK1 | 0.51544934 |
114 | ILK | 0.49573882 |
115 | GRK1 | 0.48234447 |
116 | CSNK2A1 | 0.45945072 |
117 | MKNK1 | 0.45686686 |
118 | MAP2K1 | 0.45545511 |
119 | DAPK3 | 0.44644310 |
120 | RET | 0.44047407 |
121 | CDK8 | 0.43738149 |
122 | ERBB3 | 0.43708079 |
123 | CSNK1E | 0.42315694 |
124 | RPS6KA5 | 0.41782279 |
125 | PIM2 | 0.41261603 |
126 | AURKB | 0.41168072 |
127 | CSNK1A1 | 0.40166600 |
128 | ATR | 0.40077372 |
129 | CSNK2A2 | 0.39304127 |
130 | CDK3 | 0.38449643 |
131 | TNK2 | 0.38405623 |
132 | AURKA | 0.37162677 |
133 | VRK1 | 0.36668802 |
134 | DYRK1A | 0.36514568 |
135 | PRKACA | 0.34991478 |
136 | PAK3 | 0.33228551 |
137 | STK38 | 0.32676541 |
138 | WNK1 | 0.31387392 |
139 | MAP3K1 | 0.30714312 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 4.10470997 |
2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.72749101 |
3 | Nicotine addiction_Homo sapiens_hsa05033 | 3.50349481 |
4 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 3.21323378 |
5 | Parkinsons disease_Homo sapiens_hsa05012 | 3.20084262 |
6 | Alzheimers disease_Homo sapiens_hsa05010 | 2.49631157 |
7 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.48253102 |
8 | Olfactory transduction_Homo sapiens_hsa04740 | 2.44761683 |
9 | GABAergic synapse_Homo sapiens_hsa04727 | 2.33932286 |
10 | Huntingtons disease_Homo sapiens_hsa05016 | 2.28890710 |
11 | Proteasome_Homo sapiens_hsa03050 | 2.27594761 |
12 | Mismatch repair_Homo sapiens_hsa03430 | 2.23911311 |
13 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.23726326 |
14 | Circadian entrainment_Homo sapiens_hsa04713 | 2.21852979 |
15 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.18273220 |
16 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 2.13100422 |
17 | Morphine addiction_Homo sapiens_hsa05032 | 2.12533879 |
18 | Long-term potentiation_Homo sapiens_hsa04720 | 2.11419008 |
19 | Fatty acid elongation_Homo sapiens_hsa00062 | 2.03165947 |
20 | DNA replication_Homo sapiens_hsa03030 | 2.00312122 |
21 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.97760301 |
22 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.94889925 |
23 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.89277375 |
24 | Taste transduction_Homo sapiens_hsa04742 | 1.89195469 |
25 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.87952908 |
26 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.81773793 |
27 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.80482718 |
28 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.78018105 |
29 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.75983997 |
30 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.69750797 |
31 | Insulin secretion_Homo sapiens_hsa04911 | 1.69692236 |
32 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.65525567 |
33 | Homologous recombination_Homo sapiens_hsa03440 | 1.51422657 |
34 | Salivary secretion_Homo sapiens_hsa04970 | 1.46856579 |
35 | Phototransduction_Homo sapiens_hsa04744 | 1.45405223 |
36 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.44692410 |
37 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.43755522 |
38 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.42783590 |
39 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.40269067 |
40 | Spliceosome_Homo sapiens_hsa03040 | 1.39051515 |
41 | RNA transport_Homo sapiens_hsa03013 | 1.36857013 |
42 | Base excision repair_Homo sapiens_hsa03410 | 1.36583742 |
43 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.33825436 |
44 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.33447684 |
45 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.32551107 |
46 | Renin secretion_Homo sapiens_hsa04924 | 1.32188049 |
47 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.32102180 |
48 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.30745190 |
49 | Cocaine addiction_Homo sapiens_hsa05030 | 1.30579860 |
50 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.29347860 |
51 | Long-term depression_Homo sapiens_hsa04730 | 1.29111708 |
52 | RNA degradation_Homo sapiens_hsa03018 | 1.28328003 |
53 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 1.28288218 |
54 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.23484210 |
55 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.22599332 |
56 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.21188987 |
57 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.20288459 |
58 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.16834100 |
59 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.16262937 |
60 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.15119580 |
61 | Protein export_Homo sapiens_hsa03060 | 1.11453710 |
62 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.10382709 |
63 | Ribosome_Homo sapiens_hsa03010 | 1.03414909 |
64 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.02321547 |
65 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.02290380 |
66 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.01041882 |
67 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 1.00778644 |
68 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.96832034 |
69 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.94833237 |
70 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.87894963 |
71 | Gap junction_Homo sapiens_hsa04540 | 0.87547027 |
72 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.86362281 |
73 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.81709465 |
74 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.80937836 |
75 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.80828807 |
76 | Peroxisome_Homo sapiens_hsa04146 | 0.80197455 |
77 | Cell cycle_Homo sapiens_hsa04110 | 0.78880031 |
78 | Phagosome_Homo sapiens_hsa04145 | 0.78588430 |
79 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.74252364 |
80 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.72476994 |
81 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.71789604 |
82 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.70260393 |
83 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.70231262 |
84 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.69720812 |
85 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.69682649 |
86 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.66915810 |
87 | Sulfur relay system_Homo sapiens_hsa04122 | 0.66165435 |
88 | RNA polymerase_Homo sapiens_hsa03020 | 0.66129312 |
89 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.64471783 |
90 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.62212640 |
91 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.62185668 |
92 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.60504973 |
93 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.58081928 |
94 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.56932035 |
95 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.55378431 |
96 | Alcoholism_Homo sapiens_hsa05034 | 0.54712751 |
97 | Purine metabolism_Homo sapiens_hsa00230 | 0.54208759 |
98 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.54091834 |
99 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.50850228 |
100 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.48694431 |
101 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.48036522 |
102 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.46679394 |
103 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.46058363 |
104 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.45031658 |
105 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.44602779 |
106 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.43284619 |
107 | Melanogenesis_Homo sapiens_hsa04916 | 0.42652227 |
108 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.42260206 |
109 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.41409910 |
110 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.40500515 |
111 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.40013972 |
112 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.39982419 |
113 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.38534697 |
114 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.37685835 |
115 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.37390952 |
116 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.36582697 |
117 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.36097518 |
118 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.35410486 |
119 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.34715200 |
120 | Axon guidance_Homo sapiens_hsa04360 | 0.33938681 |
121 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.33816199 |
122 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.33486492 |
123 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.33124358 |
124 | Glioma_Homo sapiens_hsa05214 | 0.30546305 |
125 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.30497425 |
126 | Circadian rhythm_Homo sapiens_hsa04710 | 0.27072419 |
127 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.26208549 |
128 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.24762466 |
129 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.23959802 |
130 | Prion diseases_Homo sapiens_hsa05020 | 0.23903679 |
131 | Metabolic pathways_Homo sapiens_hsa01100 | 0.23549439 |
132 | Carbon metabolism_Homo sapiens_hsa01200 | 0.23113193 |
133 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.21824692 |
134 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.20645085 |
135 | Basal transcription factors_Homo sapiens_hsa03022 | 0.19457819 |
136 | Endocytosis_Homo sapiens_hsa04144 | 0.19127968 |
137 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.18896044 |
138 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.18374845 |
139 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.17495972 |
140 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.14872292 |
141 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.14361121 |
142 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.12962621 |
143 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.12566501 |
144 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.11286856 |
145 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.10075876 |