PCMTD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.78535984
2L-phenylalanine catabolic process (GO:0006559)4.78535984
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.34500309
4L-phenylalanine metabolic process (GO:0006558)4.34500309
5aromatic amino acid family catabolic process (GO:0009074)3.89705454
6establishment of protein localization to Golgi (GO:0072600)3.84802326
7keratinocyte development (GO:0003334)3.80423573
8protein targeting to Golgi (GO:0000042)3.78943749
9positive regulation of glycolytic process (GO:0045821)3.77607879
10retrograde transport, vesicle recycling within Golgi (GO:0000301)3.65492969
11bile acid biosynthetic process (GO:0006699)3.51750051
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.45938080
13alpha-linolenic acid metabolic process (GO:0036109)3.30579209
14indole-containing compound catabolic process (GO:0042436)3.28196616
15indolalkylamine catabolic process (GO:0046218)3.28196616
16tryptophan catabolic process (GO:0006569)3.28196616
17kynurenine metabolic process (GO:0070189)3.18571702
18complement activation, alternative pathway (GO:0006957)3.08530218
19short-chain fatty acid metabolic process (GO:0046459)3.07858327
20tryptophan metabolic process (GO:0006568)3.06357335
21cysteine metabolic process (GO:0006534)3.06212098
22regulation of skeletal muscle contraction (GO:0014819)3.04546789
23high-density lipoprotein particle remodeling (GO:0034375)3.04153837
24coenzyme catabolic process (GO:0009109)3.00928537
25glutamate metabolic process (GO:0006536)3.00175660
26bile acid metabolic process (GO:0008206)2.98185084
27regulation of protein activation cascade (GO:2000257)2.95621094
28neural tube formation (GO:0001841)2.95383929
29regulation of protein glycosylation (GO:0060049)2.91216505
30phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.91089942
31cellular ketone body metabolic process (GO:0046950)2.89718811
32peptidyl-glutamic acid carboxylation (GO:0017187)2.88435641
33protein carboxylation (GO:0018214)2.88435641
34dicarboxylic acid biosynthetic process (GO:0043650)2.85740839
35regulation of fibrinolysis (GO:0051917)2.85044371
36glyoxylate metabolic process (GO:0046487)2.84616467
37protein localization to Golgi apparatus (GO:0034067)2.83606156
38regulation of glucokinase activity (GO:0033131)2.81620134
39regulation of hexokinase activity (GO:1903299)2.81620134
40dopamine transport (GO:0015872)2.80983767
41regulation of complement activation (GO:0030449)2.79361183
42reverse cholesterol transport (GO:0043691)2.78340470
43sulfur amino acid catabolic process (GO:0000098)2.76751240
44urea cycle (GO:0000050)2.75066195
45urea metabolic process (GO:0019627)2.75066195
46regulation of energy homeostasis (GO:2000505)2.74952066
47regulation of relaxation of muscle (GO:1901077)2.74536133
48homocysteine metabolic process (GO:0050667)2.73364334
49regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.73286251
50regulation of triglyceride catabolic process (GO:0010896)2.73011462
51tyrosine metabolic process (GO:0006570)2.72409124
52negative regulation of fibrinolysis (GO:0051918)2.70775078
53triglyceride homeostasis (GO:0070328)2.68926803
54acylglycerol homeostasis (GO:0055090)2.68926803
55alpha-amino acid catabolic process (GO:1901606)2.67524995
56aromatic amino acid family metabolic process (GO:0009072)2.66518249
57macroautophagy (GO:0016236)2.65981782
58fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.64682156
59cellular modified amino acid catabolic process (GO:0042219)2.62674097
60nitric oxide mediated signal transduction (GO:0007263)2.62626957
61regulation of germinal center formation (GO:0002634)2.62414854
62Golgi to endosome transport (GO:0006895)2.61500480
63actin-myosin filament sliding (GO:0033275)2.61380032
64muscle filament sliding (GO:0030049)2.61380032
65early endosome to late endosome transport (GO:0045022)2.60392042
66negative regulation of lipase activity (GO:0060192)2.60208346
67negative regulation of protein activation cascade (GO:2000258)2.59822858
68dicarboxylic acid catabolic process (GO:0043649)2.59587853
69protein-lipid complex remodeling (GO:0034368)2.58759555
70macromolecular complex remodeling (GO:0034367)2.58759555
71plasma lipoprotein particle remodeling (GO:0034369)2.58759555
72phospholipid efflux (GO:0033700)2.58343259
73protein K11-linked deubiquitination (GO:0035871)2.57522788
74positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.57223900
75regulation of lipoprotein metabolic process (GO:0050746)2.56350842
76cellular amino acid catabolic process (GO:0009063)2.56236058
77nitrogen cycle metabolic process (GO:0071941)2.54871898
78regulation of bile acid biosynthetic process (GO:0070857)2.53995966
79lysine catabolic process (GO:0006554)2.53918674
80lysine metabolic process (GO:0006553)2.53918674
81regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.53384539
82negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.52780834
83negative regulation of T-helper cell differentiation (GO:0045623)2.52780834
84negative regulation of protein oligomerization (GO:0032460)2.51489536
85positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.51286447
86skeletal muscle tissue regeneration (GO:0043403)2.50351562
87relaxation of cardiac muscle (GO:0055119)2.50230146
88acetyl-CoA metabolic process (GO:0006084)2.50128966
89ketone body metabolic process (GO:1902224)2.50073304
90negative regulation of cytosolic calcium ion concentration (GO:0051481)2.49183083
91prostate gland growth (GO:0060736)2.48875760
92regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.48526523
93epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.47849944
94actin-mediated cell contraction (GO:0070252)2.47237026
95cholesterol efflux (GO:0033344)2.46843644
96intra-Golgi vesicle-mediated transport (GO:0006891)2.45859257
97positive regulation of fatty acid beta-oxidation (GO:0032000)2.45041007
98plasma lipoprotein particle clearance (GO:0034381)2.44091718
99polyol catabolic process (GO:0046174)2.44021359
100negative regulation of neurotransmitter transport (GO:0051589)2.43944027
101amino-acid betaine metabolic process (GO:0006577)2.43571495
102regulation of cholesterol esterification (GO:0010872)2.42711492
103serine family amino acid catabolic process (GO:0009071)2.42693360
104myofibril assembly (GO:0030239)2.42365491
105opsonization (GO:0008228)2.41188727
106very long-chain fatty acid metabolic process (GO:0000038)2.41102933
107neuronal action potential propagation (GO:0019227)2.40602070
108positive regulation of insulin receptor signaling pathway (GO:0046628)2.40460236
109prenylation (GO:0097354)2.38933735
110protein prenylation (GO:0018342)2.38933735
111positive regulation of lipid catabolic process (GO:0050996)2.38807520
112aspartate family amino acid catabolic process (GO:0009068)2.37021791
113fatty acid elongation (GO:0030497)2.36829194
114cellular response to ethanol (GO:0071361)2.36397872
115regulation of memory T cell differentiation (GO:0043380)2.36246558
116indolalkylamine metabolic process (GO:0006586)2.34894795
117cellular biogenic amine catabolic process (GO:0042402)2.34703870
118amine catabolic process (GO:0009310)2.34703870
119regulation of type B pancreatic cell apoptotic process (GO:2000674)2.34189270
120oocyte development (GO:0048599)2.33203212
121monocarboxylic acid catabolic process (GO:0072329)2.32866099
122cytolysis (GO:0019835)2.32666178
123positive regulation of protein autophosphorylation (GO:0031954)2.31472223
124fatty acid oxidation (GO:0019395)2.31041868
125inositol phosphate catabolic process (GO:0071545)2.30892777
126locomotory exploration behavior (GO:0035641)2.30647146
127glutamate secretion (GO:0014047)2.30233487
128carboxylic acid catabolic process (GO:0046395)2.29626125
129organic acid catabolic process (GO:0016054)2.29626125
130fatty acid catabolic process (GO:0009062)2.28635765
131lipid oxidation (GO:0034440)2.28204282
132gamma-aminobutyric acid transport (GO:0015812)2.28180846
133neurotransmitter-gated ion channel clustering (GO:0072578)2.28140076
134fatty acid beta-oxidation (GO:0006635)2.27996836
135negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.27842147
136fatty-acyl-CoA biosynthetic process (GO:0046949)2.26871079
137drug catabolic process (GO:0042737)2.26648528
138positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.26511285
139positive regulation of fatty acid oxidation (GO:0046321)2.26264914
140bile acid and bile salt transport (GO:0015721)2.26239037
141fatty acid transmembrane transport (GO:1902001)2.26107716
142negative regulation of complement activation (GO:0045916)2.24666126
143regulation of sequestering of triglyceride (GO:0010889)2.24128166
144regulation of cholesterol homeostasis (GO:2000188)2.24108671
145positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.23730548
146regulation of meiosis I (GO:0060631)2.23001214
147interkinetic nuclear migration (GO:0022027)2.22108693
148phospholipid homeostasis (GO:0055091)2.21732758
149relaxation of muscle (GO:0090075)2.20630107
150fibrinolysis (GO:0042730)2.20431660
151negative regulation of alpha-beta T cell differentiation (GO:0046639)2.20213125
152drug transmembrane transport (GO:0006855)2.19804467
153valine metabolic process (GO:0006573)2.19700312
154sarcoplasmic reticulum calcium ion transport (GO:0070296)2.19319464
1552-oxoglutarate metabolic process (GO:0006103)2.19153489
156thioester biosynthetic process (GO:0035384)2.19051476
157acyl-CoA biosynthetic process (GO:0071616)2.19051476
158parental behavior (GO:0060746)2.18912949
159transcytosis (GO:0045056)2.18342512
160ethanol oxidation (GO:0006069)2.18304218
161phosphorylated carbohydrate dephosphorylation (GO:0046838)2.18227798
162inositol phosphate dephosphorylation (GO:0046855)2.18227798
163regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.16855858
164kidney morphogenesis (GO:0060993)2.15814740
165positive regulation of glycoprotein biosynthetic process (GO:0010560)2.15553430
166magnesium ion transport (GO:0015693)2.11806854
167adenosine metabolic process (GO:0046085)2.10018207
168intestinal epithelial cell development (GO:0060576)2.10017763
169negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.07812913
170dentate gyrus development (GO:0021542)2.07600680
171negative regulation of heart rate (GO:0010459)2.07431452
172positive regulation of respiratory burst (GO:0060267)2.06681856
173antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.06418603
174regulation of sarcomere organization (GO:0060297)2.06241934
175positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.04748860
176regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.04727014
177xenobiotic catabolic process (GO:0042178)2.04193162
178growth hormone receptor signaling pathway (GO:0060396)2.03435435
179negative regulation of humoral immune response (GO:0002921)2.01660772
180detection of calcium ion (GO:0005513)2.01385899
181regulation of glycolytic process (GO:0006110)2.01362774
182negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)1.99527289
183positive regulation of cardiac muscle hypertrophy (GO:0010613)1.99235876
184positive regulation of muscle hypertrophy (GO:0014742)1.99235876
185positive regulation of glycogen biosynthetic process (GO:0045725)1.99137604
186negative regulation of gluconeogenesis (GO:0045721)1.99048680
187positive regulation of inositol phosphate biosynthetic process (GO:0060732)1.98647460
188microglial cell activation (GO:0001774)1.97684180
189endocrine pancreas development (GO:0031018)1.97291053
190endothelium development (GO:0003158)1.96717267
191negative regulation of cAMP-mediated signaling (GO:0043951)1.96698549
192negative regulation of blood circulation (GO:1903523)1.96570151
193cornea development in camera-type eye (GO:0061303)1.95899777
194protein localization to cilium (GO:0061512)1.95679093
195regulation of membrane repolarization (GO:0060306)1.95669853
196regulation of regulatory T cell differentiation (GO:0045589)1.94679250
197insulin secretion (GO:0030073)1.94511155

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.63600224
2RXR_22158963_ChIP-Seq_LIVER_Mouse2.69445821
3GBX2_23144817_ChIP-Seq_PC3_Human2.55262548
4LXR_22158963_ChIP-Seq_LIVER_Mouse2.46351792
5EZH2_22144423_ChIP-Seq_EOC_Human2.34451988
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.23395193
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.08817653
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.07705219
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.04295890
10* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.03617953
11TAF15_26573619_Chip-Seq_HEK293_Human2.03185654
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.00222538
13* FLI1_27457419_Chip-Seq_LIVER_Mouse1.99595276
14IGF1R_20145208_ChIP-Seq_DFB_Human1.89933765
15JARID2_20064375_ChIP-Seq_MESCs_Mouse1.79045653
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.77782782
17FUS_26573619_Chip-Seq_HEK293_Human1.76473662
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.76399282
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.76267383
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.74383620
21MTF2_20144788_ChIP-Seq_MESCs_Mouse1.73691757
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.73568737
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.72855431
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.69534644
25EZH2_18974828_ChIP-Seq_MESCs_Mouse1.69497741
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.69497741
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.67563027
28* EZH2_27294783_Chip-Seq_NPCs_Mouse1.65842430
29AR_21572438_ChIP-Seq_LNCaP_Human1.60616747
30ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60388020
31* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60089743
32* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60081064
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.59576332
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.57627659
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.55046579
36EWS_26573619_Chip-Seq_HEK293_Human1.45270825
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45090118
38DROSHA_22980978_ChIP-Seq_HELA_Human1.45003440
39* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.44106498
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43642145
41P300_19829295_ChIP-Seq_ESCs_Human1.43363009
42* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42550357
43* NFE2_27457419_Chip-Seq_LIVER_Mouse1.42429576
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41254187
45SMAD4_21799915_ChIP-Seq_A2780_Human1.41088905
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.40978907
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38755487
48* P53_22387025_ChIP-Seq_ESCs_Mouse1.38597956
49* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.38550778
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38169794
51NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38169794
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37235210
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36959337
54EZH2_27294783_Chip-Seq_ESCs_Mouse1.36703007
55STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.35928035
56* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35679526
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34816207
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34283069
59* E2F1_18555785_Chip-Seq_ESCs_Mouse1.31607834
60* CRX_20693478_ChIP-Seq_RETINA_Mouse1.30535620
61CDX2_22108803_ChIP-Seq_LS180_Human1.30212538
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30131304
63CBP_20019798_ChIP-Seq_JUKART_Human1.29532131
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29532131
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28997699
66RNF2_27304074_Chip-Seq_ESCs_Mouse1.27069525
67BCAT_22108803_ChIP-Seq_LS180_Human1.26529691
68* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26355628
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.24730360
70ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23993791
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23190846
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.22902084
73* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.22808902
74FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22273142
75* CMYC_18555785_Chip-Seq_ESCs_Mouse1.22054813
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.21741406
77BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21121482
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21011167
79AR_25329375_ChIP-Seq_VCAP_Human1.20769560
80REST_21632747_ChIP-Seq_MESCs_Mouse1.20372782
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20273608
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19899980
83* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19600393
84TCF4_22108803_ChIP-Seq_LS180_Human1.18886722
85AHR_22903824_ChIP-Seq_MCF-7_Human1.18230465
86Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.17456789
87NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16803169
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16591054
89SOX2_19829295_ChIP-Seq_ESCs_Human1.16310318
90NANOG_19829295_ChIP-Seq_ESCs_Human1.16310318
91CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16309943
92TP53_16413492_ChIP-PET_HCT116_Human1.16150261
93SMAD_19615063_ChIP-ChIP_OVARY_Human1.16141892
94* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15908898
95PRDM14_20953172_ChIP-Seq_ESCs_Human1.15729010
96* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.15704831
97IRF8_22096565_ChIP-ChIP_GC-B_Human1.14582688
98* STAT3_18555785_Chip-Seq_ESCs_Mouse1.13213866
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12320821
100IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12111191
101* FOXA2_19822575_ChIP-Seq_HepG2_Human1.11751787
102* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11590426
103STAT3_23295773_ChIP-Seq_U87_Human1.10879916
104TP53_18474530_ChIP-ChIP_U2OS_Human1.10429569
105* RARB_27405468_Chip-Seq_BRAIN_Mouse1.09790292
106* SOX2_21211035_ChIP-Seq_LN229_Gbm1.09045390
107EP300_21415370_ChIP-Seq_HL-1_Mouse1.08502318
108TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08203646
109* P300_18555785_Chip-Seq_ESCs_Mouse1.08057235
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07422057
111ESR1_20079471_ChIP-ChIP_T-47D_Human1.07383963
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07238776
113GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06592658
114* OCT4_18555785_Chip-Seq_ESCs_Mouse1.05745491
115TAL1_26923725_Chip-Seq_HPCs_Mouse1.05532943
116TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05127587
117* SOX2_18555785_Chip-Seq_ESCs_Mouse1.04998711
118TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04704529
119RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03081570
120RUNX_20019798_ChIP-Seq_JUKART_Human1.02173375
121RXR_22108803_ChIP-Seq_LS180_Human1.00681586
122TRIM28_21343339_ChIP-Seq_HEK293_Human1.00535604
123ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99263090
124ZNF274_21170338_ChIP-Seq_K562_Hela0.97019379
125FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.96577564
126ERG_21242973_ChIP-ChIP_JURKAT_Human0.95614899
127RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95461050
128VDR_22108803_ChIP-Seq_LS180_Human0.94904550
129* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93306388
130GATA1_22025678_ChIP-Seq_K562_Human0.92766707
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91479920
132SMAD4_21741376_ChIP-Seq_HESCs_Human0.91389708
133REST_18959480_ChIP-ChIP_MESCs_Mouse0.91190830
134* TCF4_23295773_ChIP-Seq_U87_Human0.91118727
135SMAD3_21741376_ChIP-Seq_HESCs_Human0.91067284
136* RUNX2_22187159_ChIP-Seq_PCA_Human0.89524764
137NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.88256124
138ESR2_21235772_ChIP-Seq_MCF-7_Human0.88117006
139SMAD4_21741376_ChIP-Seq_EPCs_Human0.87707293
140* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87657780
141ER_23166858_ChIP-Seq_MCF-7_Human0.86541426
142* NANOG_18555785_Chip-Seq_ESCs_Mouse0.86158000
143* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85990952
144* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84711548
145AR_19668381_ChIP-Seq_PC3_Human0.83053948
146PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.82971578
147TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.82688135
148TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82581805

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.77871014
2MP0005085_abnormal_gallbladder_physiolo4.21623950
3MP0005360_urolithiasis4.12642637
4MP0003787_abnormal_imprinting3.87139222
5MP0005365_abnormal_bile_salt3.86902660
6MP0000569_abnormal_digit_pigmentation3.36240025
7MP0008875_abnormal_xenobiotic_pharmacok3.06043253
8MP0003724_increased_susceptibility_to2.89161192
9MP0004859_abnormal_synaptic_plasticity2.70654047
10MP0006054_spinal_hemorrhage2.61687692
11MP0003646_muscle_fatigue2.57714406
12MP0008877_abnormal_DNA_methylation2.57540982
13MP0003252_abnormal_bile_duct2.40513674
14MP0003880_abnormal_central_pattern2.38638386
15MP0010329_abnormal_lipoprotein_level2.36954705
16MP0002638_abnormal_pupillary_reflex2.36313331
17MP0003195_calcinosis2.31028236
18MP0004484_altered_response_of2.25064499
19MP0002822_catalepsy2.19313496
20MP0004215_abnormal_myocardial_fiber2.09558627
21MP0005083_abnormal_biliary_tract2.07741562
22MP0004270_analgesia2.06786968
23MP0001666_abnormal_nutrient_absorption2.03547541
24MP0004036_abnormal_muscle_relaxation2.00441662
25MP0003635_abnormal_synaptic_transmissio1.97667651
26MP0005332_abnormal_amino_acid1.91565768
27MP0004084_abnormal_cardiac_muscle1.88399027
28MP0010234_abnormal_vibrissa_follicle1.86857692
29MP0009745_abnormal_behavioral_response1.82723760
30MP0002118_abnormal_lipid_homeostasis1.73331647
31MP0009780_abnormal_chondrocyte_physiolo1.72977236
32MP0003690_abnormal_glial_cell1.70115234
33MP0002837_dystrophic_cardiac_calcinosis1.69428544
34MP0002064_seizures1.67720032
35MP0003329_amyloid_beta_deposits1.67662827
36MP0005620_abnormal_muscle_contractility1.67343352
37MP0004130_abnormal_muscle_cell1.67063419
38MP0002009_preneoplasia1.66474764
39MP0005464_abnormal_platelet_physiology1.65254913
40MP0003806_abnormal_nucleotide_metabolis1.60175857
41MP0003868_abnormal_feces_composition1.60092280
42MP0002063_abnormal_learning/memory/cond1.54307359
43MP0001501_abnormal_sleep_pattern1.54097260
44MP0002254_reproductive_system_inflammat1.53459667
45MP0000427_abnormal_hair_cycle1.52871903
46MP0002166_altered_tumor_susceptibility1.49185809
47MP0000383_abnormal_hair_follicle1.48866041
48MP0001486_abnormal_startle_reflex1.45873726
49MP0009046_muscle_twitch1.43673628
50MP0000013_abnormal_adipose_tissue1.39780888
51MP0008004_abnormal_stomach_pH1.39770819
52MP0002272_abnormal_nervous_system1.38944178
53MP0003191_abnormal_cellular_cholesterol1.37655449
54MP0003656_abnormal_erythrocyte_physiolo1.35613915
55MP0002572_abnormal_emotion/affect_behav1.34313404
56MP0005645_abnormal_hypothalamus_physiol1.32557292
57MP0002876_abnormal_thyroid_physiology1.30917101
58MP0005646_abnormal_pituitary_gland1.30293729
59MP0008775_abnormal_heart_ventricle1.30070355
60MP0000465_gastrointestinal_hemorrhage1.29798854
61MP0003045_fibrosis1.29368609
62MP0002972_abnormal_cardiac_muscle1.27186698
63MP0005535_abnormal_body_temperature1.26648215
64MP0001968_abnormal_touch/_nociception1.26537633
65MP0003011_delayed_dark_adaptation1.26219183
66MP0000920_abnormal_myelination1.25652169
67MP0001756_abnormal_urination1.25408167
68MP0002909_abnormal_adrenal_gland1.24943531
69MP0000749_muscle_degeneration1.23319849
70MP0000604_amyloidosis1.22585911
71MP0002102_abnormal_ear_morphology1.22272305
72MP0004885_abnormal_endolymph1.19829986
73MP0003121_genomic_imprinting1.19675306
74MP0004510_myositis1.18344047
75MP0004019_abnormal_vitamin_homeostasis1.17196854
76MP0003633_abnormal_nervous_system1.16856472
77MP0002106_abnormal_muscle_physiology1.14340269
78MP0001440_abnormal_grooming_behavior1.13344215
79MP0002163_abnormal_gland_morphology1.10782929
80MP0006276_abnormal_autonomic_nervous1.10082732
81MP0005584_abnormal_enzyme/coenzyme_acti1.09995200
82MP0002693_abnormal_pancreas_physiology1.09797448
83MP0000372_irregular_coat_pigmentation1.09527719
84MP0005174_abnormal_tail_pigmentation1.08861495
85MP0005253_abnormal_eye_physiology1.08659857
86MP0002067_abnormal_sensory_capabilities1.04708601
87MP0005369_muscle_phenotype1.02703853
88MP0000609_abnormal_liver_physiology1.02071309
89MP0004085_abnormal_heartbeat1.01937739
90MP0002734_abnormal_mechanical_nocicepti1.01121413
91MP0002090_abnormal_vision1.00500306
92MP0004147_increased_porphyrin_level0.99836517
93MP0005187_abnormal_penis_morphology0.99581416
94MP0002078_abnormal_glucose_homeostasis0.98218154
95MP0002796_impaired_skin_barrier0.96823499
96MP0005167_abnormal_blood-brain_barrier0.95478226
97MP0002736_abnormal_nociception_after0.95304447
98MP0004043_abnormal_pH_regulation0.95134635
99MP0002127_abnormal_cardiovascular_syste0.94983943
100MP0004883_abnormal_blood_vessel0.94840583
101MP0008874_decreased_physiological_sensi0.94449295
102MP0002138_abnormal_hepatobiliary_system0.92769616
103MP0010386_abnormal_urinary_bladder0.92408427
104MP0008872_abnormal_physiological_respon0.92235373
105MP0005084_abnormal_gallbladder_morpholo0.91485099
106MP0002277_abnormal_respiratory_mucosa0.90764177
107MP0002332_abnormal_exercise_endurance0.90452089
108MP0004924_abnormal_behavior0.89527556
109MP0005386_behavior/neurological_phenoty0.89527556
110MP0002971_abnormal_brown_adipose0.88965789
111MP0002108_abnormal_muscle_morphology0.88860361
112MP0003631_nervous_system_phenotype0.88299180
113MP0002168_other_aberrant_phenotype0.88216083
114MP0001661_extended_life_span0.85980404
115MP0001502_abnormal_circadian_rhythm0.84776473
116MP0009840_abnormal_foam_cell0.84158833
117MP0003828_pulmonary_edema0.83441852
118MP0010678_abnormal_skin_adnexa0.82936884
119MP0003122_maternal_imprinting0.82510800
120MP0005319_abnormal_enzyme/_coenzyme0.81459619
121MP0005220_abnormal_exocrine_pancreas0.81331161
122MP0008961_abnormal_basal_metabolism0.81208427
123MP0006072_abnormal_retinal_apoptosis0.80391011
124MP0001544_abnormal_cardiovascular_syste0.80331850
125MP0005385_cardiovascular_system_phenoty0.80331850
126MP0005075_abnormal_melanosome_morpholog0.80177157
127MP0001984_abnormal_olfaction0.79596067
128MP0002557_abnormal_social/conspecific_i0.79369794
129MP0002733_abnormal_thermal_nociception0.79226631
130MP0003283_abnormal_digestive_organ0.79212469
131MP0002928_abnormal_bile_duct0.79115828
132MP0001765_abnormal_ion_homeostasis0.78600917
133MP0003137_abnormal_impulse_conducting0.78451193
134MP0010368_abnormal_lymphatic_system0.77970889
135MP0009643_abnormal_urine_homeostasis0.76974643
136MP0002735_abnormal_chemical_nociception0.76788290
137MP0005666_abnormal_adipose_tissue0.75966658
138MP0000778_abnormal_nervous_system0.75287238
139MP0000516_abnormal_urinary_system0.74963906
140MP0005367_renal/urinary_system_phenotyp0.74963906
141MP0005670_abnormal_white_adipose0.73854770
142MP0001970_abnormal_pain_threshold0.72600970
143MP0008569_lethality_at_weaning0.72564065
144MP0005248_abnormal_Harderian_gland0.72383124
145MP0001177_atelectasis0.72217835
146MP0005379_endocrine/exocrine_gland_phen0.72091367
147MP0003183_abnormal_peptide_metabolism0.70984065
148MP0001764_abnormal_homeostasis0.69988312
149MP0000230_abnormal_systemic_arterial0.69689956
150MP0004134_abnormal_chest_morphology0.69483638
151MP0003075_altered_response_to0.69458415
152MP0005334_abnormal_fat_pad0.69280168
153MP0002066_abnormal_motor_capabilities/c0.68888190
154MP0004381_abnormal_hair_follicle0.67620761
155MP0005551_abnormal_eye_electrophysiolog0.67503132
156MP0001944_abnormal_pancreas_morphology0.67396071
157MP0005647_abnormal_sex_gland0.67202885
158MP0002229_neurodegeneration0.67093651
159MP0004142_abnormal_muscle_tone0.66958824
160MP0002069_abnormal_eating/drinking_beha0.66609359
161MP0003632_abnormal_nervous_system0.66507266
162MP0004145_abnormal_muscle_electrophysio0.65081946
163MP0004185_abnormal_adipocyte_glucose0.65022467

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.83955220
2Intrahepatic cholestasis (HP:0001406)4.76101625
3Deep venous thrombosis (HP:0002625)4.56119548
4Xanthomatosis (HP:0000991)4.33333955
5Prolonged partial thromboplastin time (HP:0003645)4.27974427
6Hyperlipoproteinemia (HP:0010980)4.22614323
7Complement deficiency (HP:0004431)3.86622921
8Ketosis (HP:0001946)3.78207587
9Focal motor seizures (HP:0011153)3.74927303
10Muscle fiber inclusion bodies (HP:0100299)3.74838589
11Nemaline bodies (HP:0003798)3.69459851
12Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.54612148
13Hypothermia (HP:0002045)3.52679580
14Ketoacidosis (HP:0001993)3.44026301
15Muscle hypertrophy of the lower extremities (HP:0008968)3.40149135
16Hypoglycemic coma (HP:0001325)3.39255684
17Hyperglycinemia (HP:0002154)3.38815681
18Calf muscle hypertrophy (HP:0008981)3.38784050
19Abnormality of monocarboxylic acid metabolism (HP:0010996)3.37654749
20Hyperventilation (HP:0002883)3.33837400
21Epidermoid cyst (HP:0200040)3.16087108
22Hematochezia (HP:0002573)3.14498785
23Neurofibrillary tangles (HP:0002185)3.12819023
24Papillary thyroid carcinoma (HP:0002895)3.10274532
25Hypobetalipoproteinemia (HP:0003563)3.01932728
26Abnormality of the common coagulation pathway (HP:0010990)3.00291702
27Abnormality of glycine metabolism (HP:0010895)2.99491802
28Abnormality of serine family amino acid metabolism (HP:0010894)2.99491802
29Abnormality of the renal cortex (HP:0011035)2.96131120
30Hypoalphalipoproteinemia (HP:0003233)2.93558456
31Thyroiditis (HP:0100646)2.91591275
32Hyperammonemia (HP:0001987)2.90637420
33Prolonged bleeding time (HP:0003010)2.89020882
34Hyperglycinuria (HP:0003108)2.88121791
35Metaphyseal dysplasia (HP:0100255)2.82375652
36Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.76986438
37Hypolipoproteinemia (HP:0010981)2.73454748
38Fat malabsorption (HP:0002630)2.69878489
39Cerebral inclusion bodies (HP:0100314)2.68740377
40Hypoglycemic seizures (HP:0002173)2.68290800
41Conjugated hyperbilirubinemia (HP:0002908)2.65610995
42Renal cortical cysts (HP:0000803)2.64261713
43Atonic seizures (HP:0010819)2.56795444
44Abnormality of glutamine family amino acid metabolism (HP:0010902)2.56638412
45Thyroid carcinoma (HP:0002890)2.56233247
46Focal seizures (HP:0007359)2.56135869
47Difficulty running (HP:0009046)2.55662103
48Hyporeflexia of lower limbs (HP:0002600)2.55373746
49Joint hemorrhage (HP:0005261)2.54608194
50Abnormality of aspartate family amino acid metabolism (HP:0010899)2.53825289
51Hyperinsulinemic hypoglycemia (HP:0000825)2.47457780
52Abnormality of methionine metabolism (HP:0010901)2.47095614
53Abnormality of the intrinsic pathway (HP:0010989)2.44686858
54Action tremor (HP:0002345)2.43819814
55Status epilepticus (HP:0002133)2.43714886
56Myokymia (HP:0002411)2.40762942
57Abnormality of complement system (HP:0005339)2.38802280
58Medial flaring of the eyebrow (HP:0010747)2.35801564
59Exercise-induced muscle cramps (HP:0003710)2.35059375
60Delayed CNS myelination (HP:0002188)2.35045205
61Intention tremor (HP:0002080)2.34534828
62Gingival bleeding (HP:0000225)2.33477501
63Abnormality of the calf musculature (HP:0001430)2.33135086
64Ventricular fibrillation (HP:0001663)2.32815501
65Abnormality of the axillary hair (HP:0100134)2.31657427
66Abnormality of secondary sexual hair (HP:0009888)2.31657427
67Scanning speech (HP:0002168)2.30916976
68Abnormality of sulfur amino acid metabolism (HP:0004339)2.29957981
69Gaze-evoked nystagmus (HP:0000640)2.28914659
70Amyloidosis (HP:0011034)2.27388540
71Generalized tonic-clonic seizures (HP:0002069)2.24875951
72Skin nodule (HP:0200036)2.24288112
73Type 1 muscle fiber predominance (HP:0003803)2.21200389
74Abnormal biliary tract morphology (HP:0012440)2.20761733
75Mitral stenosis (HP:0001718)2.20149878
76Biliary tract neoplasm (HP:0100574)2.16904430
77Absence seizures (HP:0002121)2.16276203
78Epileptic encephalopathy (HP:0200134)2.15957889
79Conjunctival hamartoma (HP:0100780)2.14299064
80Hyperglycemia (HP:0003074)2.11703731
81Distal arthrogryposis (HP:0005684)2.11662296
82Hypomagnesemia (HP:0002917)2.11549833
83Stomatitis (HP:0010280)2.08894776
84Spontaneous hematomas (HP:0007420)2.07801239
85Hypercholesterolemia (HP:0003124)2.07289834
86Bundle branch block (HP:0011710)2.07190329
87Abnormality of fatty-acid metabolism (HP:0004359)2.06504053
88Pancreatic cysts (HP:0001737)2.04573462
89Insulin-resistant diabetes mellitus (HP:0000831)2.04276150
90Gout (HP:0001997)2.02315385
91Abnormality of the left ventricular outflow tract (HP:0011103)2.02154883
92Subaortic stenosis (HP:0001682)2.02154883
93Cerebral hemorrhage (HP:0001342)2.02083520
94Abnormality of the pancreatic islet cells (HP:0006476)2.01460490
95Abnormality of endocrine pancreas physiology (HP:0012093)2.01460490
96Dysmetria (HP:0001310)2.01360402
97Abnormality of purine metabolism (HP:0004352)1.99699058
98Steatorrhea (HP:0002570)1.98645217
99Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.97357588
100Dialeptic seizures (HP:0011146)1.97326084
101Hamartoma of the eye (HP:0010568)1.97247119
102Hypoplasia of the fovea (HP:0007750)1.96795233
103Aplasia/Hypoplasia of the fovea (HP:0008060)1.96795233
104Spontaneous abortion (HP:0005268)1.96066566
105Sensorimotor neuropathy (HP:0007141)1.95763919
106Facial diplegia (HP:0001349)1.95657554
107Rimmed vacuoles (HP:0003805)1.95292640
108Curly hair (HP:0002212)1.95019336
109Symptomatic seizures (HP:0011145)1.94411737
110Aplasia/Hypoplasia affecting the retina (HP:0008061)1.94122325
111Progressive cerebellar ataxia (HP:0002073)1.93429369
112Testicular neoplasm (HP:0010788)1.92744661
113Poikilocytosis (HP:0004447)1.92331472
114Widely spaced teeth (HP:0000687)1.92318526
115Muscle fiber splitting (HP:0003555)1.92127405
116Dysdiadochokinesis (HP:0002075)1.91975528
117Anxiety (HP:0000739)1.91160313
118Methylmalonic acidemia (HP:0002912)1.91080422
119Confusion (HP:0001289)1.90898395
120Blue irides (HP:0000635)1.90545848
121Fair hair (HP:0002286)1.90534878
122Abnormal pancreas size (HP:0012094)1.90278759
123Exercise-induced myalgia (HP:0003738)1.90171553
124Metabolic alkalosis (HP:0200114)1.89836383
125Abnormality of the renal medulla (HP:0100957)1.89228041
126Myocardial infarction (HP:0001658)1.88161990
127Vascular calcification (HP:0004934)1.88131109
128Polydipsia (HP:0001959)1.87880702
129Abnormal drinking behavior (HP:0030082)1.87880702
130Abnormality of serum amino acid levels (HP:0003112)1.87256400
131Metabolic acidosis (HP:0001942)1.86941096
132Visual hallucinations (HP:0002367)1.86391939
133Impaired social interactions (HP:0000735)1.85709001
134Abnormal social behavior (HP:0012433)1.85709001
135Generalized hypopigmentation of hair (HP:0011358)1.85618935
136Increased mean platelet volume (HP:0011877)1.85277287
137Febrile seizures (HP:0002373)1.84459547
138Neoplasm of the tracheobronchial system (HP:0100552)1.83686247
139Hypochromic microcytic anemia (HP:0004840)1.83617510
140Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.83270924
141Stomach cancer (HP:0012126)1.82587094
142Pancreatic fibrosis (HP:0100732)1.82285709
143Papilledema (HP:0001085)1.81008657
144Degeneration of the lateral corticospinal tracts (HP:0002314)1.79988124
145Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79988124
146Abnormality of the corticospinal tract (HP:0002492)1.79455539
147Disproportionate short-trunk short stature (HP:0003521)1.79205008
148Abnormality of the fovea (HP:0000493)1.78913064
149Abnormality of T cell number (HP:0011839)1.78497224
150Drooling (HP:0002307)1.75404865
151Excessive salivation (HP:0003781)1.75404865
152Abnormality of potassium homeostasis (HP:0011042)1.75303453
153Epileptiform EEG discharges (HP:0011182)1.75053189
154Abolished electroretinogram (ERG) (HP:0000550)1.74988313
155Decreased circulating renin level (HP:0003351)1.74111050
156Frequent falls (HP:0002359)1.74011128
157Hypokalemia (HP:0002900)1.73542545
158Spastic gait (HP:0002064)1.73132096
159Irritability (HP:0000737)1.72712773
160Hypophosphatemic rickets (HP:0004912)1.72694286
161Areflexia of lower limbs (HP:0002522)1.72361615
162Hyperbilirubinemia (HP:0002904)1.71756069
163Abnormality of vitamin B metabolism (HP:0004340)1.71384744
164Pancreatitis (HP:0001733)1.71293855
165Poor eye contact (HP:0000817)1.71007676
166Arthropathy (HP:0003040)1.70824283
167T lymphocytopenia (HP:0005403)1.70402459
168Nephronophthisis (HP:0000090)1.69912278
169Cardiovascular calcification (HP:0011915)1.69561957
170Epistaxis (HP:0000421)1.68926112
171EEG with generalized epileptiform discharges (HP:0011198)1.68701488
172Abnormal gallbladder morphology (HP:0012437)1.66953340
173Cerebral edema (HP:0002181)1.66720341
174Increased circulating renin level (HP:0000848)1.66522251
175Hyperkalemia (HP:0002153)1.65904988
176Syncope (HP:0001279)1.65336775
177Abnormal platelet volume (HP:0011876)1.65251999
178Acanthocytosis (HP:0001927)1.65081064
179Insidious onset (HP:0003587)1.64598055
180Termporal pattern (HP:0011008)1.64598055
181Enlarged penis (HP:0000040)1.62106990
182EMG: myopathic abnormalities (HP:0003458)1.61862207
183Proximal tubulopathy (HP:0000114)1.60278986
184Long clavicles (HP:0000890)1.60221442
185Increased CSF protein (HP:0002922)1.59289451

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.46783565
2OBSCN3.45410266
3NTRK32.79484203
4INSRR2.76198967
5STK242.47802250
6MAP2K42.43618041
7ACVR1B2.38676624
8BCKDK2.35572791
9MAP3K42.06517411
10BMPR1B2.03389124
11CASK1.98942397
12ERBB31.86168602
13DAPK21.84052512
14FRK1.82998898
15FGFR21.76484499
16STK391.75491511
17MST41.74938812
18MAP4K21.74777901
19MAP2K71.71066595
20NLK1.67392102
21OXSR11.65602526
22NTRK11.60530432
23MAP3K21.54139850
24NUAK11.53926587
25PNCK1.51087469
26NTRK21.50261418
27SIK11.42052840
28WNK31.41037216
29FGFR31.38531624
30STK31.38116192
31MAPK151.36415315
32PLK21.35641461
33TRPM71.30380415
34MAP3K91.29430150
35FER1.24922974
36SGK4941.22129435
37SGK2231.22129435
38RIPK41.19617800
39TEC1.18471932
40CAMK1G1.15573497
41MAP3K121.14747237
42TXK1.11755182
43MAP3K131.10594882
44PAK31.09894177
45PAK61.08734605
46MAP3K71.06814408
47TNIK1.06810542
48KSR21.06749588
49RET1.05622425
50PIK3CA1.05247129
51EPHA31.03457081
52MAPK131.02913687
53CDK51.02563259
54SGK21.01289837
55IRAK11.00357157
56TAOK30.98060711
57MARK10.97110791
58MINK10.95910194
59WNK40.95795694
60ADRBK20.94123560
61GRK50.92792449
62FGFR40.92238754
63CAMKK20.91920159
64NEK60.91243143
65STK38L0.90986986
66PRKCH0.89735554
67SIK20.89291889
68MAPK120.88795073
69PHKG20.88345520
70PHKG10.88345520
71CAMK2A0.88035723
72PKN10.87393331
73SGK30.86633493
74AKT30.86396357
75YES10.86371453
76MYLK0.86168772
77WNK10.85772474
78PDPK10.81670191
79PINK10.81432545
80STK110.81315975
81PRKCE0.80565631
82CAMK2B0.80531979
83CAMKK10.80402172
84MARK30.79816321
85JAK10.78414295
86PIK3CG0.78409735
87BRSK20.76725811
88BMPR20.75870162
89PTK60.75808858
90MUSK0.74576161
91MAP2K10.74475300
92CSNK1G20.74130122
93BCR0.73809749
94FES0.73397359
95MST1R0.72925663
96PRKCQ0.72789849
97PRKAA20.72418301
98CAMK2D0.71455702
99SGK10.71427937
100MAP3K10.70668870
101PDK10.70035118
102PRKCG0.69726373
103PRKD30.67756901
104PDK20.67118297
105FGR0.66561688
106GRK70.66256938
107TIE10.65653766
108LATS10.65620234
109ADRBK10.64731582
110ERBB40.64033442
111CAMK2G0.63803677
112STK380.63626903
113PTK2B0.63387777
114ITK0.63339957
115SYK0.63073334
116MET0.62773847
117MAPK70.61553685
118PRKCZ0.60802775
119BTK0.60170000
120TYRO30.60048716
121KIT0.58684480
122TRIM280.57374089
123GRK10.55956020
124KSR10.55495470
125CSNK1G10.54228702
126CAMK1D0.54057502
127EPHB10.53459373
128PRKD10.52877838
129ERBB20.52768813
130HIPK20.52416884
131CSK0.51754949
132PDGFRA0.49877077
133TGFBR10.49826441
134TNK20.49674902
135MAP2K60.49615408
136PRKG10.49336148
137MARK20.48587999
138GSK3A0.48183157
139CAMK10.48117838
140TGFBR20.48059845
141GRK60.47670870
142HCK0.47430332
143MAPKAPK30.46999838
144PRKACG0.46907316
145PRKAA10.45792299
146IKBKE0.45737479
147NEK90.45400844
148BLK0.44425469
149IKBKB0.43305381
150DMPK0.43109534
151DYRK1A0.41472165
152MAP3K60.40559279
153LYN0.39808917
154TYK20.39207299

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.40274767
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.18008974
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.41765779
4Arginine biosynthesis_Homo sapiens_hsa002202.36869950
5Circadian rhythm_Homo sapiens_hsa047102.25841178
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.10981007
7Butanoate metabolism_Homo sapiens_hsa006502.03051796
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.02495276
9Propanoate metabolism_Homo sapiens_hsa006401.94086544
10Tryptophan metabolism_Homo sapiens_hsa003801.89102987
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.85894502
12Fatty acid degradation_Homo sapiens_hsa000711.79897017
13Regulation of autophagy_Homo sapiens_hsa041401.74906966
14Complement and coagulation cascades_Homo sapiens_hsa046101.72066099
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66993933
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.62101697
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.60080026
18Platelet activation_Homo sapiens_hsa046111.56507792
19PPAR signaling pathway_Homo sapiens_hsa033201.55078564
20Linoleic acid metabolism_Homo sapiens_hsa005911.53749659
21Fatty acid metabolism_Homo sapiens_hsa012121.51502509
22Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48735551
23Peroxisome_Homo sapiens_hsa041461.44047309
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.43806823
25Bile secretion_Homo sapiens_hsa049761.43452409
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.39494445
27Histidine metabolism_Homo sapiens_hsa003401.38018855
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.36677308
29Fatty acid elongation_Homo sapiens_hsa000621.36126867
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.35912516
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33448139
32Nicotine addiction_Homo sapiens_hsa050331.33138232
33Sulfur metabolism_Homo sapiens_hsa009201.32448302
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.31573731
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30230586
36Type I diabetes mellitus_Homo sapiens_hsa049401.26567777
37beta-Alanine metabolism_Homo sapiens_hsa004101.23603537
38GABAergic synapse_Homo sapiens_hsa047271.18303323
39Phototransduction_Homo sapiens_hsa047441.13875849
40Ether lipid metabolism_Homo sapiens_hsa005651.12531860
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09967205
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.09820485
43Chemical carcinogenesis_Homo sapiens_hsa052041.09436668
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.08454445
45Glutamatergic synapse_Homo sapiens_hsa047241.08227830
46ABC transporters_Homo sapiens_hsa020101.08158821
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06606133
48Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.06521972
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05183635
50Retinol metabolism_Homo sapiens_hsa008301.03202868
51Phenylalanine metabolism_Homo sapiens_hsa003601.03077111
52Caffeine metabolism_Homo sapiens_hsa002321.01682579
53Renin secretion_Homo sapiens_hsa049241.00333868
54Ovarian steroidogenesis_Homo sapiens_hsa049130.99869254
55Circadian entrainment_Homo sapiens_hsa047130.97872935
56Amphetamine addiction_Homo sapiens_hsa050310.97375409
57FoxO signaling pathway_Homo sapiens_hsa040680.96850913
58Insulin secretion_Homo sapiens_hsa049110.94245552
59Salivary secretion_Homo sapiens_hsa049700.94152152
60Long-term potentiation_Homo sapiens_hsa047200.94047002
61Fat digestion and absorption_Homo sapiens_hsa049750.93145868
62Tyrosine metabolism_Homo sapiens_hsa003500.91370565
63Arachidonic acid metabolism_Homo sapiens_hsa005900.91105774
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90325109
65Morphine addiction_Homo sapiens_hsa050320.89850768
66Staphylococcus aureus infection_Homo sapiens_hsa051500.89415251
67Fatty acid biosynthesis_Homo sapiens_hsa000610.88490064
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87890869
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86761963
70Taste transduction_Homo sapiens_hsa047420.84952116
71Pyruvate metabolism_Homo sapiens_hsa006200.83124579
72Pancreatic secretion_Homo sapiens_hsa049720.82990105
73Glycerolipid metabolism_Homo sapiens_hsa005610.82783935
74Starch and sucrose metabolism_Homo sapiens_hsa005000.80213706
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79615659
76Hematopoietic cell lineage_Homo sapiens_hsa046400.79581175
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77307930
78Protein export_Homo sapiens_hsa030600.76056730
79Gastric acid secretion_Homo sapiens_hsa049710.74904501
80Dilated cardiomyopathy_Homo sapiens_hsa054140.74658888
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.73901315
82Dopaminergic synapse_Homo sapiens_hsa047280.72547696
83Steroid biosynthesis_Homo sapiens_hsa001000.72508397
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71244576
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70883969
86mTOR signaling pathway_Homo sapiens_hsa041500.70496075
87Cocaine addiction_Homo sapiens_hsa050300.70067983
88Synaptic vesicle cycle_Homo sapiens_hsa047210.69757749
89Mineral absorption_Homo sapiens_hsa049780.68256061
90Serotonergic synapse_Homo sapiens_hsa047260.68200048
91Long-term depression_Homo sapiens_hsa047300.66708981
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65718607
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65120520
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64235577
95Calcium signaling pathway_Homo sapiens_hsa040200.64080613
96Inositol phosphate metabolism_Homo sapiens_hsa005620.62717090
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61220166
98Olfactory transduction_Homo sapiens_hsa047400.59962854
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59327475
100Chemokine signaling pathway_Homo sapiens_hsa040620.58460160
101Type II diabetes mellitus_Homo sapiens_hsa049300.58178213
102Cholinergic synapse_Homo sapiens_hsa047250.57665867
103Arginine and proline metabolism_Homo sapiens_hsa003300.57437692
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56959387
105Vitamin digestion and absorption_Homo sapiens_hsa049770.56197744
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54447702
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54221377
108Prolactin signaling pathway_Homo sapiens_hsa049170.52459599
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52380302
110Oxytocin signaling pathway_Homo sapiens_hsa049210.51992882
111Sphingolipid metabolism_Homo sapiens_hsa006000.51860759
112Prion diseases_Homo sapiens_hsa050200.51308002
113Glucagon signaling pathway_Homo sapiens_hsa049220.51104530
114Ras signaling pathway_Homo sapiens_hsa040140.51101788
115cAMP signaling pathway_Homo sapiens_hsa040240.47887096
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.47812275
117Insulin resistance_Homo sapiens_hsa049310.46692679
118Osteoclast differentiation_Homo sapiens_hsa043800.45198483
119AMPK signaling pathway_Homo sapiens_hsa041520.44419561
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.44101676
121T cell receptor signaling pathway_Homo sapiens_hsa046600.43273154
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43230182
123Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43047497
124GnRH signaling pathway_Homo sapiens_hsa049120.42881801
125Thyroid hormone synthesis_Homo sapiens_hsa049180.39433049
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39136114
127Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38896472
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36788377
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36482025
130Carbon metabolism_Homo sapiens_hsa012000.36094288
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.35671459
132Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34651474
133Lysine degradation_Homo sapiens_hsa003100.34486039
134cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34353714
135Dorso-ventral axis formation_Homo sapiens_hsa043200.34261026
136Axon guidance_Homo sapiens_hsa043600.34122867
137Collecting duct acid secretion_Homo sapiens_hsa049660.33788137

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »