PCNP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cullin deneddylation (GO:0010388)5.81743246
2protein deneddylation (GO:0000338)5.26151659
3negative regulation of dendrite morphogenesis (GO:0050774)5.03020503
4chromatin remodeling at centromere (GO:0031055)4.34502216
5signal peptide processing (GO:0006465)4.27368290
6ribosome assembly (GO:0042255)4.21225676
7lactate metabolic process (GO:0006089)4.17188348
8establishment of integrated proviral latency (GO:0075713)4.02006931
9histone exchange (GO:0043486)3.93589181
10inositol phosphate catabolic process (GO:0071545)3.88637633
11protein neddylation (GO:0045116)3.84812031
12viral protein processing (GO:0019082)3.75355767
13positive regulation of mitochondrial fission (GO:0090141)3.73599528
14ER overload response (GO:0006983)3.62418026
15protein complex biogenesis (GO:0070271)3.55337863
16regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.49413137
17DNA double-strand break processing (GO:0000729)3.45832041
18intraciliary transport (GO:0042073)3.43858377
19presynaptic membrane assembly (GO:0097105)3.42004073
20protein-cofactor linkage (GO:0018065)3.37772941
21negative regulation of mast cell activation (GO:0033004)3.34968482
22cytochrome complex assembly (GO:0017004)3.32141432
23negative regulation of DNA-dependent DNA replication (GO:2000104)3.30442471
24replication fork processing (GO:0031297)3.28839014
25deoxyribose phosphate biosynthetic process (GO:0046385)3.27274739
262-deoxyribonucleotide biosynthetic process (GO:0009265)3.27274739
27positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.26660813
28DNA replication-independent nucleosome assembly (GO:0006336)3.26040082
29DNA replication-independent nucleosome organization (GO:0034724)3.26040082
30somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.24997504
31somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.24997504
32isotype switching (GO:0045190)3.24997504
33mitochondrial respiratory chain complex I assembly (GO:0032981)3.23922598
34NADH dehydrogenase complex assembly (GO:0010257)3.23922598
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.23922598
36rRNA methylation (GO:0031167)3.23314825
37regulation of coenzyme metabolic process (GO:0051196)3.20422636
38regulation of cofactor metabolic process (GO:0051193)3.20422636
39negative regulation of dendrite development (GO:2000171)3.20252357
40regulation of acyl-CoA biosynthetic process (GO:0050812)3.19875369
41histamine secretion (GO:0001821)3.19586687
42regulation of meiosis I (GO:0060631)3.19175743
43L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.16887158
44rRNA modification (GO:0000154)3.16600738
45anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.16575254
46regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.15665608
47regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.14401164
48regulation of mitotic spindle checkpoint (GO:1903504)3.14401164
49DNA replication checkpoint (GO:0000076)3.13350502
50negative regulation of DNA recombination (GO:0045910)3.12339371
51mitochondrial respiratory chain complex assembly (GO:0033108)3.10563783
52cell differentiation involved in metanephros development (GO:0072202)3.09871859
53purine nucleobase biosynthetic process (GO:0009113)3.08311094
54respiratory chain complex IV assembly (GO:0008535)3.07338962
55positive regulation of protein autophosphorylation (GO:0031954)3.06871462
56heart contraction (GO:0060047)3.06065227
57heart process (GO:0003015)3.06065227
58ether lipid metabolic process (GO:0046485)3.05937550
59mitotic G2/M transition checkpoint (GO:0044818)3.05107182
60non-recombinational repair (GO:0000726)3.01179522
61double-strand break repair via nonhomologous end joining (GO:0006303)3.01179522
62response to X-ray (GO:0010165)3.00150548
63viral mRNA export from host cell nucleus (GO:0046784)2.99823781
64negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.97396805
65negative regulation of ligase activity (GO:0051352)2.97396805
66peripheral nervous system neuron development (GO:0048935)2.97308562
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.96007150
68tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.96007150
69spindle checkpoint (GO:0031577)2.95408054
70positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.94694727
71negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.93587482
72deoxyribonucleotide biosynthetic process (GO:0009263)2.92764403
73presynaptic membrane organization (GO:0097090)2.92664680
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.92131842
75IMP metabolic process (GO:0046040)2.92105564
76regulation of cellular amino acid metabolic process (GO:0006521)2.89959280
77DNA ligation (GO:0006266)2.88272555
78regulation of DNA endoreduplication (GO:0032875)2.87887382
79positive regulation of ligase activity (GO:0051351)2.87219166
80mannosylation (GO:0097502)2.86565079
81mitotic spindle checkpoint (GO:0071174)2.86128388
82metaphase plate congression (GO:0051310)2.84845207
83telomere maintenance via telomerase (GO:0007004)2.84528957
84protein localization to kinetochore (GO:0034501)2.82881292
85somatic diversification of immune receptors via somatic mutation (GO:0002566)2.82842542
86somatic hypermutation of immunoglobulin genes (GO:0016446)2.82842542
87mitochondrial DNA replication (GO:0006264)2.82375936
88mitotic metaphase plate congression (GO:0007080)2.80784740
89nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.80165269
90DNA replication-dependent nucleosome assembly (GO:0006335)2.79923054
91DNA replication-dependent nucleosome organization (GO:0034723)2.79923054
92postsynaptic membrane organization (GO:0001941)2.79663321
93positive regulation of protein homodimerization activity (GO:0090073)2.78644196
94mitotic sister chromatid cohesion (GO:0007064)2.77527749
95GMP metabolic process (GO:0046037)2.77515461
96intra-S DNA damage checkpoint (GO:0031573)2.77316660
97negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.76996547
98regulation of sulfur metabolic process (GO:0042762)2.76639455
99prenylation (GO:0097354)2.76386942
100protein prenylation (GO:0018342)2.76386942
101microtubule depolymerization (GO:0007019)2.75822117
102postreplication repair (GO:0006301)2.75008250
103protein localization to microtubule (GO:0035372)2.74539094
104regulation of helicase activity (GO:0051095)2.73769570
105regulation of ubiquitin-protein transferase activity (GO:0051438)2.72683407
106kinetochore organization (GO:0051383)2.72526562
107establishment of viral latency (GO:0019043)2.71560468
1087-methylguanosine mRNA capping (GO:0006370)2.70626108
109histone H2A ubiquitination (GO:0033522)2.70163751
110RNA capping (GO:0036260)2.69618819
1117-methylguanosine RNA capping (GO:0009452)2.69618819
112mitotic G2 DNA damage checkpoint (GO:0007095)2.68713720
113peptidyl-cysteine modification (GO:0018198)2.67964629
114negative regulation of mitotic sister chromatid separation (GO:2000816)2.67413539
115negative regulation of sister chromatid segregation (GO:0033046)2.67413539
116negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.67413539
117negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.67413539
118negative regulation of mitotic sister chromatid segregation (GO:0033048)2.67413539
119regulation of ligase activity (GO:0051340)2.67354253
120RNA-dependent DNA replication (GO:0006278)2.67340581
121regulation of Golgi to plasma membrane protein transport (GO:0042996)2.66927083
122negative regulation of synaptic transmission, GABAergic (GO:0032229)2.66533011
123transferrin transport (GO:0033572)2.66500586
124mismatch repair (GO:0006298)2.64307693
125poly(A)+ mRNA export from nucleus (GO:0016973)2.63128678
126signal transduction involved in DNA integrity checkpoint (GO:0072401)2.63095033
127signal transduction involved in DNA damage checkpoint (GO:0072422)2.63095033
128somatic recombination of immunoglobulin gene segments (GO:0016447)2.62825901
129mesenchymal cell differentiation involved in renal system development (GO:2001012)2.62011630
130mesenchymal cell differentiation involved in kidney development (GO:0072161)2.62011630
131protein localization to microtubule cytoskeleton (GO:0072698)2.61640335
132RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.60613118
133microtubule polymerization or depolymerization (GO:0031109)2.60492637
134inositol phosphate dephosphorylation (GO:0046855)2.59353346
135phosphorylated carbohydrate dephosphorylation (GO:0046838)2.59353346
136negative regulation of signal transduction by p53 class mediator (GO:1901797)2.58414982
137positive regulation of amino acid transport (GO:0051957)2.58367992
138regulation of mitochondrial fission (GO:0090140)2.58261223
139chaperone-mediated protein transport (GO:0072321)2.57870842
140nucleobase biosynthetic process (GO:0046112)2.57664035
141IMP biosynthetic process (GO:0006188)2.55723502
142serotonin receptor signaling pathway (GO:0007210)2.54598788
143negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.54239096
144proteasome assembly (GO:0043248)2.53487776
145adenosine metabolic process (GO:0046085)2.52662336
146DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.49798860
147histamine transport (GO:0051608)2.48916497
148signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.48783330
149signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.48783330
150signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.48783330
151negative regulation of glycogen biosynthetic process (GO:0045719)2.47215573
152protein refolding (GO:0042026)2.47079006
153ferric iron transport (GO:0015682)2.46622723
154trivalent inorganic cation transport (GO:0072512)2.46622723
155dentate gyrus development (GO:0021542)2.46554146
156signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.45886509
157intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.45886509
158positive regulation of myoblast differentiation (GO:0045663)2.44016124
159positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.43706776
160CENP-A containing nucleosome assembly (GO:0034080)2.42887072
161deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.41912163
162negative regulation of myoblast differentiation (GO:0045662)2.41409891
163regulation of amino acid transport (GO:0051955)2.40861004
164maturation of 5.8S rRNA (GO:0000460)2.40096854
165metanephric mesenchyme development (GO:0072075)2.39398235
166regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.39030546
167deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.38720338
168dopamine transport (GO:0015872)2.38671287
169protein localization to cytoskeleton (GO:0044380)2.38168315
170protein K11-linked ubiquitination (GO:0070979)2.37559082
171regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.37469083
172protein localization to cilium (GO:0061512)2.36180024
173generation of neurons (GO:0048699)2.36125779
174signal transduction involved in cell cycle checkpoint (GO:0072395)2.32566389
175DNA catabolic process, exonucleolytic (GO:0000738)2.32270803
176negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.31786195

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.34622153
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.43150849
3GBX2_23144817_ChIP-Seq_PC3_Human3.32312796
4E2F7_22180533_ChIP-Seq_HELA_Human3.07610337
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.84380258
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.64359373
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.62010397
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.48120590
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.45489201
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.40009894
11TAF15_26573619_Chip-Seq_HEK293_Human2.36614735
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.36356609
13* EST1_17652178_ChIP-ChIP_JURKAT_Human2.26816752
14EWS_26573619_Chip-Seq_HEK293_Human2.19534361
15FUS_26573619_Chip-Seq_HEK293_Human2.16657299
16PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.11383999
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10574520
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.08829316
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.06771446
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.02551928
21* ELK1_19687146_ChIP-ChIP_HELA_Human1.99918803
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97093601
23P300_19829295_ChIP-Seq_ESCs_Human1.93125096
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92055482
25* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.90937629
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85545141
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.81812837
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80774463
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78051763
30AR_21909140_ChIP-Seq_LNCAP_Human1.72239429
31VDR_22108803_ChIP-Seq_LS180_Human1.71581590
32* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66818999
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.66081513
34* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64412499
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.64355559
36* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.62056598
37FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.61306574
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.61286734
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60383503
40IGF1R_20145208_ChIP-Seq_DFB_Human1.59531688
41OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51857690
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.51383840
43* FOXP3_21729870_ChIP-Seq_TREG_Human1.51361373
44RNF2_27304074_Chip-Seq_NSC_Mouse1.50047304
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.47443078
46ZNF274_21170338_ChIP-Seq_K562_Hela1.47087375
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.45978480
48* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44692858
49FOXM1_23109430_ChIP-Seq_U2OS_Human1.44181776
50MYC_18940864_ChIP-ChIP_HL60_Human1.43466923
51ER_23166858_ChIP-Seq_MCF-7_Human1.42757782
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42497482
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42274542
54SMAD4_21799915_ChIP-Seq_A2780_Human1.41854631
55* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41158557
56E2F1_18555785_Chip-Seq_ESCs_Mouse1.40735171
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39639729
58E2F4_17652178_ChIP-ChIP_JURKAT_Human1.39138869
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.38353414
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35991086
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.34785076
62P53_22387025_ChIP-Seq_ESCs_Mouse1.34524473
63STAT3_18555785_Chip-Seq_ESCs_Mouse1.34217739
64* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33995458
65* ETS1_20019798_ChIP-Seq_JURKAT_Human1.32529228
66PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.32435011
67SUZ12_18555785_Chip-Seq_ESCs_Mouse1.30848470
68IRF1_19129219_ChIP-ChIP_H3396_Human1.30814147
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29887761
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29044324
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.28599254
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28377816
73* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.28320480
74JUN_21703547_ChIP-Seq_K562_Human1.28026270
75WT1_19549856_ChIP-ChIP_CCG9911_Human1.27920705
76RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.27059802
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26857209
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24219244
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23616144
80VDR_23849224_ChIP-Seq_CD4+_Human1.21399773
81* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20770836
82P300_18555785_Chip-Seq_ESCs_Mouse1.19996842
83NANOG_16153702_ChIP-ChIP_HESCs_Human1.19292524
84CMYC_18555785_Chip-Seq_ESCs_Mouse1.18627222
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.18574361
86NMYC_18555785_Chip-Seq_ESCs_Mouse1.18349369
87EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16828221
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13911586
89SOX2_18555785_Chip-Seq_ESCs_Mouse1.13879902
90SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13654139
91CRX_20693478_ChIP-Seq_RETINA_Mouse1.13305140
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.13070088
93E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12656378
94PIAS1_25552417_ChIP-Seq_VCAP_Human1.12423726
95* SOX9_26525672_Chip-Seq_HEART_Mouse1.11819396
96RUNX1_27457419_Chip-Seq_LIVER_Mouse1.09781077
97E2F1_21310950_ChIP-Seq_MCF-7_Human1.08185333
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08011239
99ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07301969
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06203015
101MYC_19079543_ChIP-ChIP_MESCs_Mouse1.04734743
102CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04560920
103* NANOG_19829295_ChIP-Seq_ESCs_Human1.03965921
104* SOX2_19829295_ChIP-Seq_ESCs_Human1.03965921
105SMAD3_21741376_ChIP-Seq_EPCs_Human1.01628528
106CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01505058
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01273127
108TAL1_26923725_Chip-Seq_HPCs_Mouse1.00354486
109HTT_18923047_ChIP-ChIP_STHdh_Human1.00268501
110CBX2_27304074_Chip-Seq_ESCs_Mouse1.00149055
111PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99534016
112OCT4_18555785_Chip-Seq_ESCs_Mouse0.99291563
113ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98264503
114NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97595566
115CDX2_22108803_ChIP-Seq_LS180_Human0.97321234
116FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96342383
117TP63_19390658_ChIP-ChIP_HaCaT_Human0.96024859
118DCP1A_22483619_ChIP-Seq_HELA_Human0.95846990
119* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.95140977
120TCF4_22108803_ChIP-Seq_LS180_Human0.94679340
121TTF2_22483619_ChIP-Seq_HELA_Human0.93690814
122AR_25329375_ChIP-Seq_VCAP_Human0.93643636
123ZFX_18555785_Chip-Seq_ESCs_Mouse0.93526877
124STAT3_23295773_ChIP-Seq_U87_Human0.92917760
125SALL4_22934838_ChIP-ChIP_CD34+_Human0.92877530
126CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92611618
127PU1_27457419_Chip-Seq_LIVER_Mouse0.92108042
128* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91663195

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity3.59926489
2MP0001188_hyperpigmentation3.40713407
3MP0003787_abnormal_imprinting3.33578075
4MP0009697_abnormal_copulation3.18214793
5MP0004957_abnormal_blastocyst_morpholog2.97327009
6MP0005646_abnormal_pituitary_gland2.90211846
7MP0003122_maternal_imprinting2.85252448
8MP0002876_abnormal_thyroid_physiology2.69040343
9MP0002102_abnormal_ear_morphology2.57860296
10MP0000566_synostosis2.56711596
11MP0003111_abnormal_nucleus_morphology2.37649202
12MP0003121_genomic_imprinting2.36632803
13MP0002735_abnormal_chemical_nociception2.22506175
14MP0005171_absent_coat_pigmentation2.21098888
15MP0004215_abnormal_myocardial_fiber2.10640381
16MP0004147_increased_porphyrin_level2.05589648
17MP0005367_renal/urinary_system_phenotyp2.03739043
18MP0000516_abnormal_urinary_system2.03739043
19MP0000015_abnormal_ear_pigmentation1.99930965
20MP0003123_paternal_imprinting1.97165930
21MP0008007_abnormal_cellular_replicative1.91762614
22MP0003718_maternal_effect1.89133405
23MP0004782_abnormal_surfactant_physiolog1.86983972
24MP0002009_preneoplasia1.82885444
25MP0008058_abnormal_DNA_repair1.79777932
26MP0006072_abnormal_retinal_apoptosis1.78339908
27MP0001984_abnormal_olfaction1.78132451
28MP0002163_abnormal_gland_morphology1.76271525
29MP0006036_abnormal_mitochondrial_physio1.73892484
30MP0002736_abnormal_nociception_after1.73486229
31MP0010352_gastrointestinal_tract_polyps1.70659002
32MP0001177_atelectasis1.68576995
33MP0003880_abnormal_central_pattern1.67904110
34MP0002751_abnormal_autonomic_nervous1.67332819
35MP0006292_abnormal_olfactory_placode1.63798877
36MP0008877_abnormal_DNA_methylation1.60773598
37MP0008789_abnormal_olfactory_epithelium1.59393138
38MP0002160_abnormal_reproductive_system1.59338569
39MP0002090_abnormal_vision1.57918413
40MP0001529_abnormal_vocalization1.57561926
41MP0003567_abnormal_fetal_cardiomyocyte1.57092864
42MP0000372_irregular_coat_pigmentation1.52370428
43MP0001968_abnormal_touch/_nociception1.49908968
44MP0005499_abnormal_olfactory_system1.48052584
45MP0005394_taste/olfaction_phenotype1.48052584
46MP0003943_abnormal_hepatobiliary_system1.47725714
47MP0003941_abnormal_skin_development1.45857518
48MP0005503_abnormal_tendon_morphology1.45069901
49MP0005645_abnormal_hypothalamus_physiol1.43607242
50MP0003195_calcinosis1.41559093
51MP0006276_abnormal_autonomic_nervous1.41430119
52MP0002837_dystrophic_cardiac_calcinosis1.41398460
53MP0001293_anophthalmia1.40097456
54MP0002734_abnormal_mechanical_nocicepti1.40043330
55MP0000681_abnormal_thyroid_gland1.37678304
56MP0004084_abnormal_cardiac_muscle1.37601185
57MP0010094_abnormal_chromosome_stability1.34622371
58MP0003786_premature_aging1.34424479
59MP0005464_abnormal_platelet_physiology1.33352377
60MP0005409_darkened_coat_color1.31424535
61MP0008872_abnormal_physiological_respon1.31259674
62MP0000678_abnormal_parathyroid_gland1.27552368
63MP0006054_spinal_hemorrhage1.26055238
64MP0001730_embryonic_growth_arrest1.24332970
65MP0005389_reproductive_system_phenotype1.23952304
66MP0001919_abnormal_reproductive_system1.23714564
67MP0001542_abnormal_bone_strength1.23651232
68MP0005253_abnormal_eye_physiology1.22269446
69MP0001905_abnormal_dopamine_level1.22134918
70MP0003119_abnormal_digestive_system1.20380324
71MP0003937_abnormal_limbs/digits/tail_de1.20150845
72MP0001697_abnormal_embryo_size1.18621265
73MP0003942_abnormal_urinary_system1.17608838
74MP0008057_abnormal_DNA_replication1.16120246
75MP0000647_abnormal_sebaceous_gland1.15163248
76MP0005408_hypopigmentation1.14969372
77MP0002084_abnormal_developmental_patter1.14341560
78MP0003950_abnormal_plasma_membrane1.13664649
79MP0008775_abnormal_heart_ventricle1.13404254
80MP0000049_abnormal_middle_ear1.11559127
81MP0002132_abnormal_respiratory_system1.10466921
82MP0000350_abnormal_cell_proliferation1.09236325
83MP0005187_abnormal_penis_morphology1.09109313
84MP0009745_abnormal_behavioral_response1.08412108
85MP0002233_abnormal_nose_morphology1.07958215
86MP0005551_abnormal_eye_electrophysiolog1.07695090
87MP0006035_abnormal_mitochondrial_morpho1.06637204
88MP0009250_abnormal_appendicular_skeleto1.06229023
89MP0009046_muscle_twitch1.05421903
90MP0005379_endocrine/exocrine_gland_phen1.04046125
91MP0001879_abnormal_lymphatic_vessel1.03951042
92MP0002272_abnormal_nervous_system1.03431620
93MP0003693_abnormal_embryo_hatching1.01444010
94MP0008995_early_reproductive_senescence0.98854096
95MP0000749_muscle_degeneration0.98785665
96MP0000631_abnormal_neuroendocrine_gland0.98641305
97MP0009703_decreased_birth_body0.97590404
98MP0008932_abnormal_embryonic_tissue0.95716695
99MP0001929_abnormal_gametogenesis0.95312364
100MP0002210_abnormal_sex_determination0.95161201
101MP0003385_abnormal_body_wall0.95035530
102MP0000653_abnormal_sex_gland0.94604641
103MP0001286_abnormal_eye_development0.94599087
104MP0002638_abnormal_pupillary_reflex0.94433970
105MP0008260_abnormal_autophagy0.94324610
106MP0003315_abnormal_perineum_morphology0.94209107
107MP0009672_abnormal_birth_weight0.93528775
108MP0002063_abnormal_learning/memory/cond0.93137531
109MP0004085_abnormal_heartbeat0.92919231
110MP0004134_abnormal_chest_morphology0.90890207
111MP0000358_abnormal_cell_content/0.90474818
112MP0005084_abnormal_gallbladder_morpholo0.90046279
113MP0002572_abnormal_emotion/affect_behav0.88985443
114MP0010678_abnormal_skin_adnexa0.88330459
115MP0001119_abnormal_female_reproductive0.87988242
116MP0002938_white_spotting0.87679472
117MP0001672_abnormal_embryogenesis/_devel0.86492605
118MP0005380_embryogenesis_phenotype0.86492605
119MP0002085_abnormal_embryonic_tissue0.85608096
120MP0001764_abnormal_homeostasis0.85426975
121MP0005075_abnormal_melanosome_morpholog0.84927743
122MP0009053_abnormal_anal_canal0.84612517
123MP0001145_abnormal_male_reproductive0.84046485
124MP0003283_abnormal_digestive_organ0.83654146
125MP0003011_delayed_dark_adaptation0.83367406
126MP0004270_analgesia0.83133258
127MP0002095_abnormal_skin_pigmentation0.81416146
128MP0002234_abnormal_pharynx_morphology0.81358637
129MP0003186_abnormal_redox_activity0.81289128
130MP0010386_abnormal_urinary_bladder0.80769563
131MP0010030_abnormal_orbit_morphology0.80744446
132MP0001186_pigmentation_phenotype0.78487314
133MP0010234_abnormal_vibrissa_follicle0.78098025
134MP0001963_abnormal_hearing_physiology0.78043035
135MP0005410_abnormal_fertilization0.77374541
136MP0002080_prenatal_lethality0.77234128
137MP0002067_abnormal_sensory_capabilities0.76211223
138MP0003755_abnormal_palate_morphology0.74904271
139MP0002877_abnormal_melanocyte_morpholog0.74602301
140MP0005220_abnormal_exocrine_pancreas0.73794451
141MP0003806_abnormal_nucleotide_metabolis0.73547818
142MP0003077_abnormal_cell_cycle0.73517433
143MP0009780_abnormal_chondrocyte_physiolo0.72416248
144MP0000026_abnormal_inner_ear0.72278053
145MP0002064_seizures0.72201429
146MP0008004_abnormal_stomach_pH0.71643062
147MP0003984_embryonic_growth_retardation0.71444137
148MP0002088_abnormal_embryonic_growth/wei0.71278983
149MP0000778_abnormal_nervous_system0.69216160
150MP0004142_abnormal_muscle_tone0.68931163
151MP0003698_abnormal_male_reproductive0.68061826
152MP0003136_yellow_coat_color0.66565918
153MP0002822_catalepsy0.61501389
154MP0003890_abnormal_embryonic-extraembry0.61215515
155MP0003635_abnormal_synaptic_transmissio0.60455823

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hair whorl (HP:0010721)4.58492928
2Hypothermia (HP:0002045)4.04637815
3Pancreatic islet-cell hyperplasia (HP:0004510)3.67857837
4Type I transferrin isoform profile (HP:0003642)3.56455752
5Hypoglycemic seizures (HP:0002173)3.53025063
6Hypoglycemic coma (HP:0001325)3.43600169
7True hermaphroditism (HP:0010459)3.39792965
8Hyperinsulinemic hypoglycemia (HP:0000825)3.30178773
9Medial flaring of the eyebrow (HP:0010747)3.29750285
10Abnormality of methionine metabolism (HP:0010901)3.25518037
11Nephrogenic diabetes insipidus (HP:0009806)3.19520037
12Acute necrotizing encephalopathy (HP:0006965)3.14839181
13Congenital primary aphakia (HP:0007707)3.14740017
14Gait imbalance (HP:0002141)3.03712896
15Abnormality of the pancreatic islet cells (HP:0006476)2.94506545
16Abnormality of endocrine pancreas physiology (HP:0012093)2.94506545
17Dyschromatopsia (HP:0007641)2.90676893
18Abnormal mitochondria in muscle tissue (HP:0008316)2.87770686
19Pancreatic fibrosis (HP:0100732)2.86788793
20Progressive macrocephaly (HP:0004481)2.85029361
21Abnormality of aspartate family amino acid metabolism (HP:0010899)2.83502521
22Poor coordination (HP:0002370)2.82717274
23Febrile seizures (HP:0002373)2.80601737
24Biliary tract neoplasm (HP:0100574)2.72786474
25Increased mean platelet volume (HP:0011877)2.71342603
26Genital tract atresia (HP:0001827)2.70378600
27Embryonal renal neoplasm (HP:0011794)2.69890899
28Absent eyebrow (HP:0002223)2.68976796
29Alveolar cell carcinoma (HP:0006519)2.68874922
30Methylmalonic acidemia (HP:0002912)2.66215323
31Vaginal atresia (HP:0000148)2.66028233
32Abnormality of incisor morphology (HP:0011063)2.65208458
33Increased hepatocellular lipid droplets (HP:0006565)2.59419068
34Nephroblastoma (Wilms tumor) (HP:0002667)2.56204574
35Abnormal lung lobation (HP:0002101)2.54058532
36Colon cancer (HP:0003003)2.53458478
37Abnormality of chromosome stability (HP:0003220)2.50610835
38Syringomyelia (HP:0003396)2.45289766
39Spinal cord lesions (HP:0100561)2.45289766
40Neoplasm of the adrenal gland (HP:0100631)2.45116740
41Mitochondrial inheritance (HP:0001427)2.42761926
42Meckel diverticulum (HP:0002245)2.39815157
43Symptomatic seizures (HP:0011145)2.38975537
44Increased CSF lactate (HP:0002490)2.35646751
45Abnormal auditory evoked potentials (HP:0006958)2.35046508
46Abnormality of the anterior horn cell (HP:0006802)2.34925716
47Degeneration of anterior horn cells (HP:0002398)2.34925716
48Thyroid carcinoma (HP:0002890)2.34811852
49Tongue fasciculations (HP:0001308)2.33954160
50Aplasia/Hypoplasia of the tibia (HP:0005772)2.33238183
51Lipid accumulation in hepatocytes (HP:0006561)2.33088021
52Asymmetry of the thorax (HP:0001555)2.31797859
53Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.30464125
54Abnormal protein N-linked glycosylation (HP:0012347)2.30464125
55Abnormal protein glycosylation (HP:0012346)2.30464125
56Abnormal glycosylation (HP:0012345)2.30464125
57Neuroendocrine neoplasm (HP:0100634)2.29876929
58Acute encephalopathy (HP:0006846)2.28138956
59Papillary thyroid carcinoma (HP:0002895)2.26875954
60Pheochromocytoma (HP:0002666)2.26212130
61Volvulus (HP:0002580)2.25658881
62Ovarian neoplasm (HP:0100615)2.25440602
63Sensory axonal neuropathy (HP:0003390)2.24044193
64Abnormality of the ileum (HP:0001549)2.20784959
65Focal motor seizures (HP:0011153)2.19582126
66Atonic seizures (HP:0010819)2.19446531
67Neoplasm of the small intestine (HP:0100833)2.18740802
68Epileptic encephalopathy (HP:0200134)2.18559223
69Abnormal platelet volume (HP:0011876)2.18327488
70Neoplasm of the colon (HP:0100273)2.17938331
71Reduced antithrombin III activity (HP:0001976)2.17614870
72Preaxial hand polydactyly (HP:0001177)2.16806157
73Aplasia/Hypoplasia of the fovea (HP:0008060)2.16767201
74Hypoplasia of the fovea (HP:0007750)2.16767201
75Neoplasm of the adrenal cortex (HP:0100641)2.16253904
76Ependymoma (HP:0002888)2.14500402
77Abnormality of the fovea (HP:0000493)2.14418047
78Deep philtrum (HP:0002002)2.12510049
79Postaxial foot polydactyly (HP:0001830)2.12144569
80Abnormal biliary tract morphology (HP:0012440)2.12108525
81Birth length less than 3rd percentile (HP:0003561)2.11269175
82Hypoplastic left heart (HP:0004383)2.10763833
83Adrenal hypoplasia (HP:0000835)2.10245724
84Chromosomal breakage induced by crosslinking agents (HP:0003221)2.09218421
85Neoplasm of the tracheobronchial system (HP:0100552)2.09166437
86Hyperglycemia (HP:0003074)2.09155404
87Pancreatic cysts (HP:0001737)2.08313830
88Aplasia/Hypoplasia of the uvula (HP:0010293)2.08210160
89Short tibia (HP:0005736)2.07434531
90Submucous cleft hard palate (HP:0000176)2.06992650
91Renal Fanconi syndrome (HP:0001994)2.06585524
92Broad foot (HP:0001769)2.05886773
93Exertional dyspnea (HP:0002875)2.05745866
94Bifid tongue (HP:0010297)2.04812648
95Abnormality of glycolysis (HP:0004366)2.03630430
96Increased serum pyruvate (HP:0003542)2.03630430
97Absent eyelashes (HP:0000561)2.01819883
98Hepatoblastoma (HP:0002884)2.01160529
99Chromsome breakage (HP:0040012)2.00088492
100Long foot (HP:0001833)1.99739286
101Prominent metopic ridge (HP:0005487)1.97859361
102Diastasis recti (HP:0001540)1.97304075
103Megaloblastic anemia (HP:0001889)1.97302737
104Duodenal stenosis (HP:0100867)1.96856496
105Small intestinal stenosis (HP:0012848)1.96856496
106Abnormality of vitamin B metabolism (HP:0004340)1.96555250
107Abnormality of the preputium (HP:0100587)1.96493275
108Rhabdomyosarcoma (HP:0002859)1.96365476
109Tubulointerstitial nephritis (HP:0001970)1.95540754
110Abnormality of the labia minora (HP:0012880)1.95275133
111Neoplasm of the rectum (HP:0100743)1.95046376
112Abnormality of the duodenum (HP:0002246)1.94403014
113Heterochromia iridis (HP:0001100)1.94292168
114Postnatal microcephaly (HP:0005484)1.94249188
115Microvesicular hepatic steatosis (HP:0001414)1.93514276
116Occipital encephalocele (HP:0002085)1.93169856
117Hyperventilation (HP:0002883)1.92115886
118Palpitations (HP:0001962)1.91261814
119Hepatocellular necrosis (HP:0001404)1.90218531
120Protruding tongue (HP:0010808)1.89976985
121Metaphyseal dysplasia (HP:0100255)1.89290875
122Myelodysplasia (HP:0002863)1.86897557
123Abnormality of serum amino acid levels (HP:0003112)1.86525089
124Hypoplastic heart (HP:0001961)1.86195485
125Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85026775
126Abnormality of alanine metabolism (HP:0010916)1.85026775
127Hyperalaninemia (HP:0003348)1.85026775
128Renal cortical cysts (HP:0000803)1.84379856
129Irregular epiphyses (HP:0010582)1.84157487
130Abnormality of the metopic suture (HP:0005556)1.83559088
131Uterine neoplasm (HP:0010784)1.83248149
13211 pairs of ribs (HP:0000878)1.83156026
133Cerebral edema (HP:0002181)1.83036183
134Patchy hypopigmentation of hair (HP:0011365)1.82079001
135Hypomagnesemia (HP:0002917)1.81855780
136Glioma (HP:0009733)1.79473371
137Curly hair (HP:0002212)1.79221159
138Facial cleft (HP:0002006)1.78672222
139Short middle phalanx of the 5th finger (HP:0004220)1.78430303
140Aplasia/Hypoplasia of the lens (HP:0008063)1.78022326
141Failure to thrive in infancy (HP:0001531)1.76539966
142Muscle fibrillation (HP:0010546)1.75646265
143Abnormality of the vitamin B12 metabolism (HP:0004341)1.75565602
144Breast carcinoma (HP:0003002)1.75312866
145Cystic hygroma (HP:0000476)1.73680678
146Intestinal atresia (HP:0011100)1.73243676
147Type 2 muscle fiber atrophy (HP:0003554)1.73018662
148Exercise intolerance (HP:0003546)1.72265369
149Posterior subcapsular cataract (HP:0007787)1.72211333
150Meningioma (HP:0002858)1.72155302
151Abnormality of sulfur amino acid metabolism (HP:0004339)1.71721549
152Cutaneous melanoma (HP:0012056)1.71548963
153Congenital, generalized hypertrichosis (HP:0004540)1.71186694
154Increased serum lactate (HP:0002151)1.70278941
155Median cleft lip (HP:0000161)1.68811533
156Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.67835517
157Enlarged kidneys (HP:0000105)1.67652296
158Aganglionic megacolon (HP:0002251)1.67161427
159Postaxial hand polydactyly (HP:0001162)1.66813050
160Sloping forehead (HP:0000340)1.66168481
161Hepatic necrosis (HP:0002605)1.66107983
1623-Methylglutaconic aciduria (HP:0003535)1.65811277
163Chronic hepatic failure (HP:0100626)1.63037837
164Fetal akinesia sequence (HP:0001989)1.62753173
165Central scotoma (HP:0000603)1.62632648
166Muscular hypotonia of the trunk (HP:0008936)1.62575635
167Long clavicles (HP:0000890)1.62440678
168Molar tooth sign on MRI (HP:0002419)1.62306219
169Abnormality of midbrain morphology (HP:0002418)1.62306219
170Progressive inability to walk (HP:0002505)1.62276240
171Abnormality of the nasolacrimal system (HP:0000614)1.60255835

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.67949219
2AKT34.00588369
3TRIM283.98439334
4PRPF4B3.51563108
5SIK33.31691200
6ERBB32.79458485
7MAP3K122.63803914
8ZAK2.48689016
9SGK22.37490572
10TNIK2.22917557
11BMPR22.19355416
12CCNB12.18013925
13PLK22.14845648
14BCR2.11449912
15WEE12.11369449
16TSSK62.09198228
17ACVR1B2.08850507
18MAP3K142.00550437
19MAP2K71.95062868
20MKNK21.88223089
21YES11.87797881
22TTK1.82379915
23MKNK11.80746366
24WNK31.75563374
25STK31.74497939
26SGK2231.66695553
27SGK4941.66695553
28PLK31.60146205
29BMPR1B1.46056875
30STK38L1.44900561
31CDK81.44860047
32EIF2AK11.42106689
33FRK1.39778864
34MYLK1.39738881
35SRPK11.37678067
36NEK61.37314836
37SGK31.33685339
38MAPK131.31547943
39MAP4K21.31242147
40STK161.30454732
41VRK11.26356791
42NEK91.25493605
43BRAF1.25414803
44STK241.23805209
45EIF2AK31.21077491
46VRK21.19534628
47BRSK21.15730536
48LATS11.09651789
49ADRBK21.06816052
50MST41.05847499
51PLK41.04446903
52NUAK11.03167892
53TXK1.03078754
54TAF10.97583452
55BUB10.90716582
56PNCK0.86253082
57EIF2AK20.86180135
58TGFBR10.83292640
59DAPK10.82484083
60BRSK10.81403648
61CSNK1G10.79861847
62MINK10.78563642
63NLK0.78422669
64TRPM70.75424676
65IRAK40.74926384
66RPS6KB10.74917981
67LIMK10.72839171
68FGFR10.71982738
69CSNK1G20.70960625
70PINK10.70729426
71FGFR20.69052905
72PRKD30.67419596
73CLK10.65107069
74CDK30.65038490
75RPS6KC10.64705489
76RPS6KL10.64705489
77CSNK1G30.63660757
78RPS6KA60.62226825
79PIK3CA0.61461270
80PAK30.61226447
81PRKCE0.60968461
82OBSCN0.57262948
83RPS6KA20.56477673
84ATM0.56107780
85EPHA30.55888258
86MAP3K40.55588184
87PBK0.55453816
88STK390.55447999
89PIM20.54161777
90STK40.52218528
91ALK0.51440118
92NTRK30.49926626
93FLT30.48812441
94PRKCG0.48216496
95OXSR10.47619351
96PDK20.45408065
97TAOK20.44103558
98RPS6KA40.43927704
99CAMKK20.42328048
100FER0.42216728
101TESK10.41972960
102NEK10.39657136
103STK100.39109605
104BRD40.37854201
105TNK20.37544149
106GRK10.36798228
107CSNK1E0.36471127
108CSNK1A1L0.36425167
109CHUK0.36375538
110TEC0.36079706
111ILK0.36069402
112CSNK2A10.34923758
113PLK10.34904143
114GRK70.34902422
115GRK50.33558432
116DYRK20.33478484
117PHKG10.32778677
118PHKG20.32778677
119PASK0.32342501
120CDC70.31557397
121ATR0.31505612
122PRKCH0.31416668
123AURKB0.30221997
124NME10.30136308
125ERBB40.29545684
126CSNK2A20.29168236
127MAP2K40.28508714
128PIM10.27244983
129IRAK30.26738719
130MUSK0.26560353
131SGK10.25788459
132CAMK2B0.25718320
133CAMK2A0.25678450
134CHEK20.24987838
135MAPK70.24901804
136PAK10.24777926
137INSRR0.24141320
138CHEK10.23645887
139PDK30.23528419
140CAMK2D0.22566804
141ROCK20.22207140
142ADRBK10.20349790
143PAK40.20277806
144BMX0.19900796
145PRKCB0.19462811
146CDK60.19025989

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.47384202
2Proteasome_Homo sapiens_hsa030503.41988617
3SNARE interactions in vesicular transport_Homo sapiens_hsa041302.72674059
4Collecting duct acid secretion_Homo sapiens_hsa049662.51707920
5Propanoate metabolism_Homo sapiens_hsa006402.41335583
6Oxidative phosphorylation_Homo sapiens_hsa001902.27096204
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.23579905
8Mismatch repair_Homo sapiens_hsa034302.23507381
9Base excision repair_Homo sapiens_hsa034102.16853006
10RNA polymerase_Homo sapiens_hsa030202.14641596
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.03544185
12Basal transcription factors_Homo sapiens_hsa030221.98777514
13Vibrio cholerae infection_Homo sapiens_hsa051101.98496521
14Synaptic vesicle cycle_Homo sapiens_hsa047211.97340463
15DNA replication_Homo sapiens_hsa030301.93869893
16Parkinsons disease_Homo sapiens_hsa050121.83249909
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.81866956
18Non-homologous end-joining_Homo sapiens_hsa034501.80702241
19Homologous recombination_Homo sapiens_hsa034401.80012429
20RNA degradation_Homo sapiens_hsa030181.72097309
21Nucleotide excision repair_Homo sapiens_hsa034201.70469595
22Vitamin B6 metabolism_Homo sapiens_hsa007501.69609520
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.66429029
24Steroid biosynthesis_Homo sapiens_hsa001001.64878012
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.64265431
26Rheumatoid arthritis_Homo sapiens_hsa053231.57092474
27Fanconi anemia pathway_Homo sapiens_hsa034601.55130814
28Cell cycle_Homo sapiens_hsa041101.54938388
29Huntingtons disease_Homo sapiens_hsa050161.54389436
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51264170
31Nicotine addiction_Homo sapiens_hsa050331.39633916
32Phagosome_Homo sapiens_hsa041451.38058577
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37166545
34Purine metabolism_Homo sapiens_hsa002301.32836193
35Pyrimidine metabolism_Homo sapiens_hsa002401.32813693
36Selenocompound metabolism_Homo sapiens_hsa004501.32152630
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.30858054
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25653414
39Nitrogen metabolism_Homo sapiens_hsa009101.23544299
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.23270468
41Type I diabetes mellitus_Homo sapiens_hsa049401.23129886
42Phototransduction_Homo sapiens_hsa047441.22712353
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.22447770
44Olfactory transduction_Homo sapiens_hsa047401.21948940
45Arachidonic acid metabolism_Homo sapiens_hsa005901.21105031
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14496588
47Alzheimers disease_Homo sapiens_hsa050101.13176018
48Spliceosome_Homo sapiens_hsa030401.13059397
49Circadian rhythm_Homo sapiens_hsa047101.09741971
50Serotonergic synapse_Homo sapiens_hsa047261.09628771
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08721608
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08330831
53Glutathione metabolism_Homo sapiens_hsa004801.07883300
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07549680
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.07348025
56Butanoate metabolism_Homo sapiens_hsa006501.06361053
57Sulfur metabolism_Homo sapiens_hsa009201.01009174
58RNA transport_Homo sapiens_hsa030131.00860231
59Autoimmune thyroid disease_Homo sapiens_hsa053200.99269260
60Legionellosis_Homo sapiens_hsa051340.98301121
61mRNA surveillance pathway_Homo sapiens_hsa030150.97517641
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94354946
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93495115
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91824366
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90779558
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85495704
67Taste transduction_Homo sapiens_hsa047420.85072559
68N-Glycan biosynthesis_Homo sapiens_hsa005100.84965312
69Allograft rejection_Homo sapiens_hsa053300.84056274
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81099167
71Carbon metabolism_Homo sapiens_hsa012000.79647137
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79299327
73Morphine addiction_Homo sapiens_hsa050320.78721629
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77840810
75Melanoma_Homo sapiens_hsa052180.72513175
76Epstein-Barr virus infection_Homo sapiens_hsa051690.72080800
77Biosynthesis of amino acids_Homo sapiens_hsa012300.71083860
78Peroxisome_Homo sapiens_hsa041460.70804300
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70120559
80Dopaminergic synapse_Homo sapiens_hsa047280.68744598
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67676513
82One carbon pool by folate_Homo sapiens_hsa006700.66123033
83Galactose metabolism_Homo sapiens_hsa000520.65453051
84Amphetamine addiction_Homo sapiens_hsa050310.63703436
85Thyroid cancer_Homo sapiens_hsa052160.63511736
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63270438
87Asthma_Homo sapiens_hsa053100.61960051
88Circadian entrainment_Homo sapiens_hsa047130.61522649
89Fatty acid metabolism_Homo sapiens_hsa012120.59252578
90Folate biosynthesis_Homo sapiens_hsa007900.55582784
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54586358
92Regulation of autophagy_Homo sapiens_hsa041400.54155686
93GABAergic synapse_Homo sapiens_hsa047270.53635870
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53354377
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52040438
96beta-Alanine metabolism_Homo sapiens_hsa004100.51882535
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51525370
98Fatty acid elongation_Homo sapiens_hsa000620.51267465
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51246245
100Sphingolipid metabolism_Homo sapiens_hsa006000.47767841
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45083837
102Measles_Homo sapiens_hsa051620.44593049
103Caffeine metabolism_Homo sapiens_hsa002320.43718273
104Arginine and proline metabolism_Homo sapiens_hsa003300.43574613
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41003088
106Graft-versus-host disease_Homo sapiens_hsa053320.40657841
107Long-term potentiation_Homo sapiens_hsa047200.40386181
108Fatty acid degradation_Homo sapiens_hsa000710.39482024
109Long-term depression_Homo sapiens_hsa047300.39410976
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.39202400
111Oocyte meiosis_Homo sapiens_hsa041140.39066067
112Adherens junction_Homo sapiens_hsa045200.37754258
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37432778
114Endometrial cancer_Homo sapiens_hsa052130.35142487
115Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34988317
116Metabolic pathways_Homo sapiens_hsa011000.33877561
117Tight junction_Homo sapiens_hsa045300.33821475
118Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33721206
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33681301
120p53 signaling pathway_Homo sapiens_hsa041150.33529579
121Hedgehog signaling pathway_Homo sapiens_hsa043400.33025057
122Ether lipid metabolism_Homo sapiens_hsa005650.32434273
123Insulin secretion_Homo sapiens_hsa049110.31728700
124Influenza A_Homo sapiens_hsa051640.31689486
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30886143
126Prostate cancer_Homo sapiens_hsa052150.30816693
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29080761
128Hippo signaling pathway_Homo sapiens_hsa043900.29020450
129TGF-beta signaling pathway_Homo sapiens_hsa043500.28896703
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.28668388
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28648566
132Fructose and mannose metabolism_Homo sapiens_hsa000510.28464693
133Platelet activation_Homo sapiens_hsa046110.26684010
134Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26225103
135Pyruvate metabolism_Homo sapiens_hsa006200.25572046
136Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25391165
137Retinol metabolism_Homo sapiens_hsa008300.25333922
138Glutamatergic synapse_Homo sapiens_hsa047240.24883317
139Herpes simplex infection_Homo sapiens_hsa051680.23993155
140Starch and sucrose metabolism_Homo sapiens_hsa005000.23165915
141Wnt signaling pathway_Homo sapiens_hsa043100.22494340
142Pentose phosphate pathway_Homo sapiens_hsa000300.22050724
143Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21244099

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