PCNPP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous antigen (GO:0019883)9.19198232
2negative regulation of catenin import into nucleus (GO:0035414)8.83073609
3negative regulation of granulocyte differentiation (GO:0030853)8.64717424
4mitotic nuclear envelope reassembly (GO:0007084)7.85548802
5nuclear envelope reassembly (GO:0031468)7.85548802
6peptidyl-lysine dimethylation (GO:0018027)7.45380228
7proteasome assembly (GO:0043248)7.31516730
8regulation of antigen processing and presentation (GO:0002577)7.17594592
9negative regulation of bone resorption (GO:0045779)7.00283654
10positive regulation of B cell differentiation (GO:0045579)6.92252256
11adaptation of signaling pathway (GO:0023058)6.55741351
12positive regulation of protein export from nucleus (GO:0046827)6.04971726
13T cell migration (GO:0072678)5.95093012
14platelet dense granule organization (GO:0060155)5.93499544
15negative regulation of bone remodeling (GO:0046851)5.92992901
16determination of adult lifespan (GO:0008340)5.84675044
17positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc5.64158028
18establishment of protein localization to mitochondrial membrane (GO:0090151)5.44852673
19leukocyte tethering or rolling (GO:0050901)5.41047775
20negative regulation of multicellular organism growth (GO:0040015)5.24367593
21immunoglobulin mediated immune response (GO:0016064)5.23349272
22regulation of synapse maturation (GO:0090128)5.23306094
23autophagic vacuole fusion (GO:0000046)5.11933817
24regulation of monocyte differentiation (GO:0045655)5.01008464
25negative regulation of tissue remodeling (GO:0034104)4.99809582
26cell proliferation in forebrain (GO:0021846)4.99559587
27positive regulation by organism of defense response of other organism involved in symbiotic interact4.82344952
28modulation by symbiont of host immune response (GO:0052553)4.82344952
29positive regulation by symbiont of host defense response (GO:0052509)4.82344952
30modulation by symbiont of host defense response (GO:0052031)4.82344952
31modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.82344952
32modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.82344952
33regulation of interleukin-6 biosynthetic process (GO:0045408)4.79486766
34negative regulation of B cell proliferation (GO:0030889)4.70080765
35negative regulation of osteoclast differentiation (GO:0045671)4.67845469
36macrophage activation involved in immune response (GO:0002281)4.65538393
37cerebral cortex radially oriented cell migration (GO:0021799)4.55153665
38regulation of granulocyte differentiation (GO:0030852)4.39237537
39organelle membrane fusion (GO:0090174)4.28008795
40regulation of B cell differentiation (GO:0045577)4.23493864
41activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)4.11598918
42mitochondrial calcium ion homeostasis (GO:0051560)3.99084043
43B cell mediated immunity (GO:0019724)3.92520050
44neutrophil activation involved in immune response (GO:0002283)3.78118015
45microglial cell activation (GO:0001774)3.73510152
46coronary vasculature morphogenesis (GO:0060977)3.69165120
47regulation of interferon-beta biosynthetic process (GO:0045357)3.65331878
48adrenergic receptor signaling pathway (GO:0071875)3.59760011
49brown fat cell differentiation (GO:0050873)3.59616775
50peptidyl-lysine trimethylation (GO:0018023)3.58840365
51negative regulation of systemic arterial blood pressure (GO:0003085)3.56513312
52positive regulation of erythrocyte differentiation (GO:0045648)3.52119342
53peroxisome fission (GO:0016559)3.50541470
54heterotypic cell-cell adhesion (GO:0034113)3.50483592
55TOR signaling (GO:0031929)3.50041067
56oxygen transport (GO:0015671)3.49581099
57pericardium development (GO:0060039)3.49291841
58glycerol metabolic process (GO:0006071)3.42333678
59cellular response to exogenous dsRNA (GO:0071360)3.37217670
60regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:23.35643491
61negative regulation of smooth muscle contraction (GO:0045986)3.30499447
62peptidyl-lysine methylation (GO:0018022)3.27537148
63regulation of catenin import into nucleus (GO:0035412)3.22578269
64multi-organism intracellular transport (GO:1902583)3.17824804
65transport of virus (GO:0046794)3.17824804
66intracellular transport of virus (GO:0075733)3.17824804
67multi-organism transport (GO:0044766)3.17824804
68multi-organism localization (GO:1902579)3.17824804
69positive regulation of chemokine biosynthetic process (GO:0045080)3.16057786
70phosphatidylinositol dephosphorylation (GO:0046856)3.14618262
71response to host immune response (GO:0052572)3.09848605
72response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.09848605
73positive regulation of neuroblast proliferation (GO:0002052)3.07735455
74alditol metabolic process (GO:0019400)3.06714360
75thrombin receptor signaling pathway (GO:0070493)3.04258454
76lymphocyte migration (GO:0072676)2.98077831
77male meiosis I (GO:0007141)2.96667476
78negative regulation of interleukin-6 production (GO:0032715)2.94023766
79phospholipid dephosphorylation (GO:0046839)2.93895171
80regulation of protein export from nucleus (GO:0046825)2.91077557
81signal peptide processing (GO:0006465)2.87989917
82gas transport (GO:0015669)2.87173986
83positive regulation of toll-like receptor signaling pathway (GO:0034123)2.82248379
84anterograde synaptic vesicle transport (GO:0048490)2.69481688
85cellular response to interferon-beta (GO:0035458)2.63080142
86negative regulation of B cell activation (GO:0050869)2.62478001
87energy coupled proton transport, down electrochemical gradient (GO:0015985)2.62253032
88ATP synthesis coupled proton transport (GO:0015986)2.62253032
89response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.62028988
90response to host (GO:0075136)2.62028988
91response to host defenses (GO:0052200)2.62028988
92response to dietary excess (GO:0002021)2.59619133
93positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.53727161
94secretory granule organization (GO:0033363)2.53714291
95regulation of antigen processing and presentation of peptide antigen (GO:0002583)17.1176136
96DNA strand renaturation (GO:0000733)16.3442675
97antigen processing and presentation via MHC class Ib (GO:0002475)15.6864618
98antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)12.4665710
99antigen processing and presentation of endogenous peptide antigen (GO:0002483)11.1223052
100positive regulation of antigen processing and presentation (GO:0002579)10.0652274

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.79773019
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.36881280
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.22797613
4IRF8_22096565_ChIP-ChIP_GC-B_Human5.11386815
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.03487115
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.65508016
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.42036323
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.32462457
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.32120001
10IKZF1_21737484_ChIP-ChIP_HCT116_Human2.62072087
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.08530128
12BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.93026827
13ESR1_15608294_ChIP-ChIP_MCF-7_Human1.87830678
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59931629
15TRIM28_21343339_ChIP-Seq_HEK293_Human1.59517156
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.58645270
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.53630683
18PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49206058
19NANOG_18555785_Chip-Seq_ESCs_Mouse1.43037998
20BP1_19119308_ChIP-ChIP_Hs578T_Human1.42144809
21ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.37734321
22BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37336706
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36937011
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.36855970
25VDR_22108803_ChIP-Seq_LS180_Human1.36402486
26ETV1_20927104_ChIP-Seq_GIST48_Human1.36312019
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.36176232
28P53_22387025_ChIP-Seq_ESCs_Mouse1.35973755
29CMYC_18555785_Chip-Seq_ESCs_Mouse1.35515123
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33877930
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.33077506
32SOX2_18555785_Chip-Seq_ESCs_Mouse1.32922069
33SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.31637147
34TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30335344
35P300_19829295_ChIP-Seq_ESCs_Human1.29368384
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27566501
37GATA6_21074721_ChIP-Seq_CACO-2_Human1.26373175
38PHF8_20622853_ChIP-Seq_HELA_Human1.24771010
39GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.24211813
40EZH2_27304074_Chip-Seq_ESCs_Mouse1.23278822
41CBX2_22325352_ChIP-Seq_293T-Rex_Human1.22012023
42CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20231001
43CRX_20693478_ChIP-Seq_RETINA_Mouse1.18777835
44PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.17855240
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.17410961
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.17317537
47IGF1R_20145208_ChIP-Seq_DFB_Human1.17182362
48EZH2_22144423_ChIP-Seq_EOC_Human1.17065719
49SCL_19346495_ChIP-Seq_HPC-7_Human1.15003092
50E2F1_18555785_Chip-Seq_ESCs_Mouse1.14468353
51OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14337151
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12323810
53P300_18555785_Chip-Seq_ESCs_Mouse1.11747650
54ZFX_18555785_Chip-Seq_ESCs_Mouse1.10463722
55RUNX_20019798_ChIP-Seq_JUKART_Human1.10443555
56RBPJ_21746931_ChIP-Seq_IB4_Human1.10125893
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09643570
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09643570
59CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.08940671
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08670392
61TDRD3_21172665_ChIP-Seq_MCF-7_Human1.07481804
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07083945
63KLF4_18555785_Chip-Seq_ESCs_Mouse1.06346848
64GATA1_22025678_ChIP-Seq_K562_Human1.06074265
65SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05781198
66NMYC_18555785_Chip-Seq_ESCs_Mouse1.04857025
67GABP_17652178_ChIP-ChIP_JURKAT_Human1.04262180
68STAT3_18555785_Chip-Seq_ESCs_Mouse1.04068057
69IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02349208
70SOX2_19829295_ChIP-Seq_ESCs_Human1.02257720
71NANOG_19829295_ChIP-Seq_ESCs_Human1.02257720
72NCOR_22424771_ChIP-Seq_293T_Human1.01942918
73RUNX1_26923725_Chip-Seq_HPCs_Mouse1.01312323
74SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99490740
75TP53_22573176_ChIP-Seq_HFKS_Human0.99144136
76EWS_26573619_Chip-Seq_HEK293_Human0.98894247
77ESRRB_18555785_Chip-Seq_ESCs_Mouse0.98747442
78NFYA_21822215_ChIP-Seq_K562_Human0.98512200
79CBX2_27304074_Chip-Seq_ESCs_Mouse0.97930712
80FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96503775
81FOXA1_25329375_ChIP-Seq_VCAP_Human0.96503775
82RNF2_27304074_Chip-Seq_ESCs_Mouse0.96454862
83PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95883186
84FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95407154
85FOXH1_21741376_ChIP-Seq_EPCs_Human0.95043383
86OCT4_18555785_Chip-Seq_ESCs_Mouse0.94643664
87EZH2_27294783_Chip-Seq_ESCs_Mouse0.93577417
88SUZ12_27294783_Chip-Seq_ESCs_Mouse0.93000551
89CTCF_18555785_Chip-Seq_ESCs_Mouse0.92860730
90PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92600044
91RNF2_27304074_Chip-Seq_NSC_Mouse0.92474353
92CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91057515
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90997056
94FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89688899
95EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.88856867
96RUNX1_27457419_Chip-Seq_LIVER_Mouse0.88576590
97TP53_20018659_ChIP-ChIP_R1E_Mouse0.87574274
98EED_16625203_ChIP-ChIP_MESCs_Mouse0.87386634
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87152277
100SMAD1_18555785_Chip-Seq_ESCs_Mouse0.86293536

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot8.06769100
2MP0003878_abnormal_ear_physiology8.06769100
3MP0002102_abnormal_ear_morphology6.89201066
4MP0001835_abnormal_antigen_presentation6.23977736
5MP0002166_altered_tumor_susceptibility4.42250959
6MP0003879_abnormal_hair_cell4.29709868
7MP0000685_abnormal_immune_system3.76793817
8MP0005671_abnormal_response_to3.59508314
9MP0002006_tumorigenesis3.35584774
10MP0001485_abnormal_pinna_reflex2.92593876
11MP0004742_abnormal_vestibular_system2.44368206
12MP0005360_urolithiasis2.25194773
13MP0002933_joint_inflammation2.21996802
14MP0001486_abnormal_startle_reflex2.20928283
15MP0000372_irregular_coat_pigmentation1.75835554
16MP0003137_abnormal_impulse_conducting1.56763875
17MP0001545_abnormal_hematopoietic_system1.45979260
18MP0005397_hematopoietic_system_phenotyp1.45979260
19MP0005464_abnormal_platelet_physiology1.38118542
20MP0001440_abnormal_grooming_behavior1.38043636
21MP0003136_yellow_coat_color1.37336686
22MP0002396_abnormal_hematopoietic_system1.32429774
23MP0004885_abnormal_endolymph1.32329363
24MP0004142_abnormal_muscle_tone1.26843145
25MP0005075_abnormal_melanosome_morpholog1.26274001
26MP0003111_abnormal_nucleus_morphology1.24293147
27MP0005387_immune_system_phenotype1.20071544
28MP0001790_abnormal_immune_system1.20071544
29MP0002332_abnormal_exercise_endurance1.19079727
30MP0002163_abnormal_gland_morphology1.19031254
31MP0001188_hyperpigmentation1.12927464
32MP0001873_stomach_inflammation1.01584460
33MP0003866_abnormal_defecation1.00207786
34MP0009250_abnormal_appendicular_skeleto0.99039023
35MP0004381_abnormal_hair_follicle0.97940302
36MP0009764_decreased_sensitivity_to0.93585314
37MP0005025_abnormal_response_to0.93021325
38MP0001986_abnormal_taste_sensitivity0.92122277
39MP0002837_dystrophic_cardiac_calcinosis0.91274596
40MP0002822_catalepsy0.87413435
41MP0002419_abnormal_innate_immunity0.86701668
42MP0006082_CNS_inflammation0.85390913
43MP0002277_abnormal_respiratory_mucosa0.83906064
44MP0005187_abnormal_penis_morphology0.81084540
45MP0002138_abnormal_hepatobiliary_system0.80688771
46MP0005551_abnormal_eye_electrophysiolog0.80626390
47MP0009046_muscle_twitch0.76505760
48MP0005084_abnormal_gallbladder_morpholo0.75867584
49MP0001800_abnormal_humoral_immune0.74688261
50MP0002272_abnormal_nervous_system0.74047438
51MP0005379_endocrine/exocrine_gland_phen0.73702127
52MP0003252_abnormal_bile_duct0.73140263
53MP0005645_abnormal_hypothalamus_physiol0.72680951
54MP0003724_increased_susceptibility_to0.72330498
55MP0002420_abnormal_adaptive_immunity0.71675818
56MP0002452_abnormal_antigen_presenting0.71481508
57MP0001819_abnormal_immune_cell0.71153663
58MP0005220_abnormal_exocrine_pancreas0.69766973
59MP0005423_abnormal_somatic_nervous0.67010320
60MP0002998_abnormal_bone_remodeling0.66797482
61MP0005275_abnormal_skin_tensile0.64373990
62MP0001963_abnormal_hearing_physiology0.63357039
63MP0000716_abnormal_immune_system0.62371701
64MP0001968_abnormal_touch/_nociception0.61664328
65MP0006072_abnormal_retinal_apoptosis0.61411576
66MP0005000_abnormal_immune_tolerance0.59552137
67MP0004808_abnormal_hematopoietic_stem0.59361917
68MP0008872_abnormal_physiological_respon0.57889532
69MP0002148_abnormal_hypersensitivity_rea0.57745269
70MP0001119_abnormal_female_reproductive0.54600422
71MP0003638_abnormal_response/metabolism_0.53835336
72MP0002139_abnormal_hepatobiliary_system0.53491077
73MP0002928_abnormal_bile_duct0.52594874
74MP0002693_abnormal_pancreas_physiology0.52514724
75MP0003195_calcinosis0.52201726
76MP0000026_abnormal_inner_ear0.51320880
77MP0001845_abnormal_inflammatory_respons0.50828376
78MP0003011_delayed_dark_adaptation0.50148597
79MP0002723_abnormal_immune_serum0.48130627
80MP0001853_heart_inflammation0.47557213
81MP0010155_abnormal_intestine_physiology0.47550591
82MP0002067_abnormal_sensory_capabilities0.42438067
83MP0002090_abnormal_vision0.42222613
84MP0002735_abnormal_chemical_nociception0.41847248
85MP0008995_early_reproductive_senescence0.41116728
86MP0004924_abnormal_behavior0.40802196
87MP0005386_behavior/neurological_phenoty0.40802196
88MP0002572_abnormal_emotion/affect_behav0.40463109
89MP0002429_abnormal_blood_cell0.39915422
90MP0005410_abnormal_fertilization0.39247215
91MP0000230_abnormal_systemic_arterial0.38924969
92MP0008569_lethality_at_weaning0.36604823
93MP0002009_preneoplasia0.35121472
94MP0003937_abnormal_limbs/digits/tail_de0.35066930
95MP0004085_abnormal_heartbeat0.34162352
96MP0004134_abnormal_chest_morphology0.33676830
97MP0009745_abnormal_behavioral_response0.32023242
98MP0004145_abnormal_muscle_electrophysio0.31309289
99MP0000343_altered_response_to0.30050874
100MP0003183_abnormal_peptide_metabolism0.29877135

Predicted human phenotypes

RankGene SetZ-score
1Nasal polyposis (HP:0100582)8.97817851
2Elevated erythrocyte sedimentation rate (HP:0003565)8.41465110
3Chronic sinusitis (HP:0011109)8.15340987
4Large eyes (HP:0001090)7.70641092
5Abnormality of the nasal mucosa (HP:0000433)7.61810558
6Muscle fiber atrophy (HP:0100295)7.37602627
7Recurrent bronchitis (HP:0002837)6.58111550
8Shawl scrotum (HP:0000049)6.05432981
9Abnormality of the fingertips (HP:0001211)5.98802461
10Achilles tendon contracture (HP:0001771)5.98477202
11Atrioventricular block (HP:0001678)5.77909150
12Flat capital femoral epiphysis (HP:0003370)5.60346677
13Abnormality of the Achilles tendon (HP:0005109)5.50868947
14Reduced subcutaneous adipose tissue (HP:0003758)5.40453787
15Esophageal atresia (HP:0002032)5.03410897
16Basal ganglia calcification (HP:0002135)4.30740660
17Bronchitis (HP:0012387)4.02516369
18Elbow flexion contracture (HP:0002987)3.84513320
19Large earlobe (HP:0009748)3.79155904
20Heart block (HP:0012722)3.67117433
21Flexion contracture of toe (HP:0005830)3.56568594
22Joint contractures involving the joints of the feet (HP:0100492)3.56568594
23Abnormality of macular pigmentation (HP:0008002)3.47315110
24Rib fusion (HP:0000902)3.46122267
25Respiratory difficulties (HP:0002880)3.45000776
26Microcytic anemia (HP:0001935)3.40128062
27Abnormal atrioventricular conduction (HP:0005150)3.37223494
28Large for gestational age (HP:0001520)3.36538779
29Ectopia lentis (HP:0001083)3.33020910
30Overlapping toe (HP:0001845)3.32547547
31Gastrointestinal atresia (HP:0002589)3.24887509
32Patchy hypopigmentation of hair (HP:0011365)3.17771706
33Trismus (HP:0000211)3.17388170
34Midline defect of the nose (HP:0004122)2.95837337
35Prominent nose (HP:0000448)2.85940059
36Agnosia (HP:0010524)2.78233612
37Emphysema (HP:0002097)2.74153642
38Hypergammaglobulinemia (HP:0010702)2.73469406
39Erythema (HP:0010783)2.73336528
40Beaking of vertebral bodies (HP:0004568)2.73216233
41Clubbing of toes (HP:0100760)2.65517279
42Long toe (HP:0010511)2.61961849
43Hypertriglyceridemia (HP:0002155)2.47858510
44Trigonocephaly (HP:0000243)2.47229069
45Bronchiectasis (HP:0002110)2.46040040
46Deep philtrum (HP:0002002)2.38355346
47Decreased electroretinogram (ERG) amplitude (HP:0000654)2.30904507
48Severe visual impairment (HP:0001141)2.25633384
49Hemiplegia (HP:0002301)2.21145647
50Abnormality of the basal ganglia (HP:0002134)2.19882019
51Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.19105620
52Abolished electroretinogram (ERG) (HP:0000550)2.09182980
53Chronic otitis media (HP:0000389)12.8593071
54Patellar aplasia (HP:0006443)1.99115504
55Primary atrial arrhythmia (HP:0001692)1.96356275
56Growth hormone deficiency (HP:0000824)1.91567789
57Vacuolated lymphocytes (HP:0001922)1.91279896
58Abnormality of chromosome segregation (HP:0002916)1.91175959
59Abnormality of the antihelix (HP:0009738)1.89267250
60Macroglossia (HP:0000158)1.88527433
61Hypoproteinemia (HP:0003075)1.88129908
62Supraventricular tachycardia (HP:0004755)1.86137942
63Axonal loss (HP:0003447)1.84916698
64Aplasia/Hypoplasia of the patella (HP:0006498)1.83589957
65Supraventricular arrhythmia (HP:0005115)1.80314390
66Increased IgM level (HP:0003496)1.80211006
67Encephalitis (HP:0002383)1.75967489
68Abnormality of the heme biosynthetic pathway (HP:0010472)1.73085116
69Septo-optic dysplasia (HP:0100842)1.73079241
70Arthrogryposis multiplex congenita (HP:0002804)1.70664976
71Decreased central vision (HP:0007663)1.68669171
72Bone pain (HP:0002653)1.65073403
73Proximal placement of thumb (HP:0009623)1.64802606
74Blepharitis (HP:0000498)1.62354599
75Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.61471331
76Decreased activity of mitochondrial respiratory chain (HP:0008972)1.61471331
77Wide intermamillary distance (HP:0006610)1.56494150
78Overfolded helix (HP:0000396)1.52839425
79Acute hepatic failure (HP:0006554)1.50624036
80Anxiety (HP:0000739)1.50566633
81Disinhibition (HP:0000734)1.48467237
82Waddling gait (HP:0002515)1.47865827
83Arachnodactyly (HP:0001166)1.47495557
84Childhood onset (HP:0011463)1.46680742
85Increased neuronal autofluorescent lipopigment (HP:0002074)1.43587446
86Deviation of the thumb (HP:0009603)1.43278166
87Abnormal hemoglobin (HP:0011902)1.42464475
88Tetraplegia (HP:0002445)1.41924982
89Abnormality of the epiphysis of the femoral head (HP:0010574)1.40557194
90Renal cortical cysts (HP:0000803)1.37597892
91Hyponatremia (HP:0002902)1.35644488
92Camptodactyly of toe (HP:0001836)1.33847602
93Cardiomegaly (HP:0001640)1.32980718
94Abnormality of femoral epiphyses (HP:0006499)1.32306475
95Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.32306475
96Abnormally folded helix (HP:0008544)1.30723608
97Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.29264260
98Abnormality of the femoral head (HP:0003368)1.28610218
99Hypoplasia of the uterus (HP:0000013)1.26758863
100Hemivertebrae (HP:0002937)1.26575209

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK77.31121153
2MOS6.63071777
3TGFBR26.51721899
4STK104.25695494
5GRK53.92107224
6MAP3K103.18299659
7INSRR2.81150475
8AKT32.70124905
9PTK22.38839076
10EIF2AK22.27222376
11NUAK12.23584174
12KIT2.06852693
13DMPK1.65349596
14LRRK21.47161594
15ADRBK11.46092333
16HCK1.25918965
17FRK1.17765835
18PINK11.09977349
19IRAK41.05606036
20CLK11.05486319
21MAP4K20.97421008
22MUSK0.93830471
23FLT30.93537543
24MAPK130.90330327
25AURKA0.84300257
26SYK0.82104735
27PRKCG0.79447365
28TNIK0.79171526
29STK160.77570051
30RAF10.73925850
31NME20.72620641
32PLK40.67461522
33TLK10.66624282
34WNK30.66581666
35BRAF0.65580952
36IRAK20.64173810
37LCK0.63762223
38PRKCD0.63367717
39ADRBK20.62484123
40CDK40.61510538
41ABL10.61048835
42PHKG20.61027663
43PHKG10.61027663
44MAP3K40.60137639
45MAPKAPK20.59681055
46FES0.57119489
47RPS6KA50.56474550
48PDK10.55768628
49PRKG10.53506032
50PIM10.52532820
51JAK20.52131036
52PAK10.51642460
53TEC0.48391459
54ILK0.46933344
55OXSR10.46200986
56TIE10.46059135
57BMPR1B0.45454237
58PRKACA0.45307051
59OBSCN0.44651734
60LYN0.42597959
61CSF1R0.41290930
62TSSK60.40951041
63IGF1R0.40481116
64ZAK0.38254569
65BLK0.37992707
66GRK10.37712850
67DYRK30.34812244
68KDR0.33241889
69DYRK20.31267140
70PRKCB0.30933186
71MATK0.30858876
72PRKCQ0.27518406
73IRAK10.26413922
74PRKCE0.26387860
75SGK10.23339369
76TXK0.23168203
77RPS6KA40.22197896
78TNK20.21775479
79VRK10.21473711
80JAK10.21016944
81PRKACB0.20626766
82ACVR1B0.19747828
83SGK2230.19403137
84SGK4940.19403137
85BMPR20.19119070
86PRKDC0.18726915
87MINK10.18561033
88INSR0.17493569
89SGK20.16954314
90SRC0.16479329
91MAPK120.16221927
92BMX0.16207650
93CSNK2A10.16077490
94MAP2K70.15924934
95ROCK10.15455480
96BRD40.13822053
97FER0.13042959
98PRKCA0.12895061
99MAP2K60.11857703
100PRKACG0.10015894

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.98205018
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.50322903
3ABC transporters_Homo sapiens_hsa020103.43637405
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.40522462
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.08056467
6Histidine metabolism_Homo sapiens_hsa003402.81258620
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.63842214
8beta-Alanine metabolism_Homo sapiens_hsa004102.52585795
9Basal transcription factors_Homo sapiens_hsa030222.51729209
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.49566238
11Antigen processing and presentation_Homo sapiens_hsa046122.37042277
12Dilated cardiomyopathy_Homo sapiens_hsa054142.21735578
13Proteasome_Homo sapiens_hsa030502.11974054
14Ribosome_Homo sapiens_hsa030102.02018581
15Salivary secretion_Homo sapiens_hsa049701.92633836
16Asthma_Homo sapiens_hsa053101.88020403
17Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.81169335
18Graft-versus-host disease_Homo sapiens_hsa053321.75737691
19Allograft rejection_Homo sapiens_hsa053301.73432979
20Autoimmune thyroid disease_Homo sapiens_hsa053201.72053292
21Type I diabetes mellitus_Homo sapiens_hsa049401.66638756
22Cardiac muscle contraction_Homo sapiens_hsa042601.55237112
23Systemic lupus erythematosus_Homo sapiens_hsa053221.51618201
24Carbohydrate digestion and absorption_Homo sapiens_hsa049731.48509550
25Mineral absorption_Homo sapiens_hsa049781.41638153
26Viral myocarditis_Homo sapiens_hsa054161.35947226
27Arginine and proline metabolism_Homo sapiens_hsa003301.34529335
28Protein digestion and absorption_Homo sapiens_hsa049741.27804635
29Retinol metabolism_Homo sapiens_hsa008301.26539702
30Herpes simplex infection_Homo sapiens_hsa051681.23974861
31Protein export_Homo sapiens_hsa030601.22588576
32Phagosome_Homo sapiens_hsa041451.22168965
33Tyrosine metabolism_Homo sapiens_hsa003501.18925902
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.18053740
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.15170492
36Taste transduction_Homo sapiens_hsa047421.13702027
37Oxidative phosphorylation_Homo sapiens_hsa001901.13491371
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.12558823
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10676352
40Gastric acid secretion_Homo sapiens_hsa049711.06577029
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04783936
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03284075
43Hematopoietic cell lineage_Homo sapiens_hsa046400.97498066
44Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96887016
45Olfactory transduction_Homo sapiens_hsa047400.96245709
46Regulation of autophagy_Homo sapiens_hsa041400.95733644
47Pancreatic secretion_Homo sapiens_hsa049720.94845393
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.93836985
49Bile secretion_Homo sapiens_hsa049760.93622606
50Phototransduction_Homo sapiens_hsa047440.91949573
51Staphylococcus aureus infection_Homo sapiens_hsa051500.89431804
52ECM-receptor interaction_Homo sapiens_hsa045120.85743486
53Parkinsons disease_Homo sapiens_hsa050120.85551042
54Huntingtons disease_Homo sapiens_hsa050160.82551886
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79950358
56Sulfur metabolism_Homo sapiens_hsa009200.77664288
57Insulin secretion_Homo sapiens_hsa049110.74940777
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74574092
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73372526
60Nicotine addiction_Homo sapiens_hsa050330.73009797
61Linoleic acid metabolism_Homo sapiens_hsa005910.71135074
62Vitamin digestion and absorption_Homo sapiens_hsa049770.67020806
63Thyroid hormone synthesis_Homo sapiens_hsa049180.66547734
64Renin secretion_Homo sapiens_hsa049240.65679692
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64633321
66Chemical carcinogenesis_Homo sapiens_hsa052040.62432164
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60045263
68Malaria_Homo sapiens_hsa051440.58687681
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56455924
70cAMP signaling pathway_Homo sapiens_hsa040240.52849488
71Inositol phosphate metabolism_Homo sapiens_hsa005620.52348804
72Alzheimers disease_Homo sapiens_hsa050100.52275945
73Alcoholism_Homo sapiens_hsa050340.52180350
74B cell receptor signaling pathway_Homo sapiens_hsa046620.51551325
75Fatty acid degradation_Homo sapiens_hsa000710.49726419
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47377535
77RNA polymerase_Homo sapiens_hsa030200.45399177
78Rheumatoid arthritis_Homo sapiens_hsa053230.44332698
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39855491
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.38772714
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37608946
82Nitrogen metabolism_Homo sapiens_hsa009100.37390459
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36968258
84Leishmaniasis_Homo sapiens_hsa051400.36302166
85Calcium signaling pathway_Homo sapiens_hsa040200.35853201
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.35011568
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34761695
88Peroxisome_Homo sapiens_hsa041460.34328039
89Renin-angiotensin system_Homo sapiens_hsa046140.32079048
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31062597
91GABAergic synapse_Homo sapiens_hsa047270.30247640
92Tuberculosis_Homo sapiens_hsa051520.26960900
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26885532
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26749299
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.25419129
96Glycerolipid metabolism_Homo sapiens_hsa005610.24430751
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.24110993
98Morphine addiction_Homo sapiens_hsa050320.18146401
99Caffeine metabolism_Homo sapiens_hsa002320.17412065
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.16230139

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