PCNT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.75419337
2nuclear pore organization (GO:0006999)5.38261381
3actin-myosin filament sliding (GO:0033275)5.21954313
4muscle filament sliding (GO:0030049)5.21954313
5protein localization to kinetochore (GO:0034501)4.84287617
6sarcoplasmic reticulum calcium ion transport (GO:0070296)4.75588430
7response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.57102018
8skeletal muscle contraction (GO:0003009)4.52163068
9mitotic chromosome condensation (GO:0007076)4.47468170
10pore complex assembly (GO:0046931)4.35339962
11actin-mediated cell contraction (GO:0070252)4.34495507
12protein localization to chromosome, centromeric region (GO:0071459)4.23762980
13mitotic sister chromatid segregation (GO:0000070)4.19716501
14sister chromatid segregation (GO:0000819)4.17124175
15mitotic nuclear envelope disassembly (GO:0007077)4.16888996
16pre-miRNA processing (GO:0031054)4.16755997
17negative regulation of histone methylation (GO:0031061)4.13345456
18DNA unwinding involved in DNA replication (GO:0006268)4.11567636
19myofibril assembly (GO:0030239)4.08950971
20histone H3-K4 trimethylation (GO:0080182)4.08268954
21regulation of histone H3-K9 methylation (GO:0051570)4.07337766
22mitotic sister chromatid cohesion (GO:0007064)4.04547254
23regulation of DNA endoreduplication (GO:0032875)3.91990946
24nuclear envelope disassembly (GO:0051081)3.89355710
25membrane disassembly (GO:0030397)3.89355710
26skeletal muscle adaptation (GO:0043501)3.84378844
27regulation of skeletal muscle contraction (GO:0014819)3.83249086
28histone H3-K4 methylation (GO:0051568)3.70965022
29response to inactivity (GO:0014854)3.70582465
30actin filament-based movement (GO:0030048)3.66462896
31DNA duplex unwinding (GO:0032508)3.64662933
32DNA geometric change (GO:0032392)3.64529391
33sarcomere organization (GO:0045214)3.64246596
34regulation of posttranscriptional gene silencing (GO:0060147)3.62725693
35regulation of gene silencing by miRNA (GO:0060964)3.62725693
36regulation of gene silencing by RNA (GO:0060966)3.62725693
37regulation of RNA export from nucleus (GO:0046831)3.60628841
38regulation of mitotic spindle organization (GO:0060236)3.60426827
39positive regulation of chromosome segregation (GO:0051984)3.60385456
40DNA replication-dependent nucleosome assembly (GO:0006335)3.60343543
41DNA replication-dependent nucleosome organization (GO:0034723)3.60343543
42chromatin assembly (GO:0031497)3.59257684
43regulation of relaxation of muscle (GO:1901077)3.57429624
44dosage compensation (GO:0007549)3.55966644
45heterochromatin organization (GO:0070828)3.53657998
46regulation of spindle organization (GO:0090224)3.52943985
47positive regulation of mitotic sister chromatid separation (GO:1901970)3.51797024
48positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.51797024
49positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.51797024
50negative regulation of cell cycle G2/M phase transition (GO:1902750)3.50035446
51mitotic metaphase plate congression (GO:0007080)3.46477506
52regulation of sister chromatid cohesion (GO:0007063)3.46194687
53striated muscle contraction (GO:0006941)3.46123321
54negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.45305355
55histone-serine phosphorylation (GO:0035404)3.44889722
56regulation of histone H3-K4 methylation (GO:0051569)3.41854657
57regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.41212414
58DNA topological change (GO:0006265)3.39851264
59histone lysine methylation (GO:0034968)3.36711168
60sister chromatid cohesion (GO:0007062)3.34327435
61peptidyl-lysine trimethylation (GO:0018023)3.32946239
62regulation of NFAT protein import into nucleus (GO:0051532)3.32487421
63cardiac myofibril assembly (GO:0055003)3.32137563
64IMP biosynthetic process (GO:0006188)3.29400997
65negative regulation of cell size (GO:0045792)3.28289416
66metaphase plate congression (GO:0051310)3.25293099
67interkinetic nuclear migration (GO:0022027)3.23648298
68mRNA stabilization (GO:0048255)3.22499440
69RNA stabilization (GO:0043489)3.22499440
70glucocorticoid receptor signaling pathway (GO:0042921)3.21945295
71actomyosin structure organization (GO:0031032)3.19287873
72regulation of translational fidelity (GO:0006450)3.17117551
73chromatin assembly or disassembly (GO:0006333)3.16636359
74nuclear envelope organization (GO:0006998)3.15561766
75chromosome condensation (GO:0030261)3.14843434
76DNA replication initiation (GO:0006270)3.13626131
77creatine metabolic process (GO:0006600)3.13540270
78DNA replication checkpoint (GO:0000076)3.12787481
79plasma membrane repair (GO:0001778)3.12098109
80DNA conformation change (GO:0071103)3.11501167
81kinetochore organization (GO:0051383)3.11393037
82protein localization to chromosome (GO:0034502)3.09968382
83DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.09904316
84folic acid-containing compound biosynthetic process (GO:0009396)3.08715849
85IMP metabolic process (GO:0046040)3.07810041
86histone H2A monoubiquitination (GO:0035518)3.04501870
87DNA synthesis involved in DNA repair (GO:0000731)3.04396245
88regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.00955247
89cardiac muscle hypertrophy (GO:0003300)2.98751732
90establishment of spindle localization (GO:0051293)2.98284194
91histone phosphorylation (GO:0016572)2.97780890
92striated muscle atrophy (GO:0014891)2.97561595
93positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.97480862
94regulation of histone H3-K27 methylation (GO:0061085)2.96628331
95striated muscle adaptation (GO:0014888)2.93266640
96nucleus localization (GO:0051647)2.92948585
97meiotic chromosome segregation (GO:0045132)2.92654185
98trophectodermal cell differentiation (GO:0001829)2.91514065
99determination of adult lifespan (GO:0008340)2.90228377
100peptidyl-lysine methylation (GO:0018022)2.89048705
101NLS-bearing protein import into nucleus (GO:0006607)2.88014709
102histone methylation (GO:0016571)2.87954436
103establishment of chromosome localization (GO:0051303)2.87164187
104positive regulation of SMAD protein import into nucleus (GO:0060391)2.85670510
105regulation of gene silencing (GO:0060968)2.84277907
106DNA packaging (GO:0006323)2.83450147
107DNA strand elongation involved in DNA replication (GO:0006271)2.83241331
108histone H3-K36 demethylation (GO:0070544)2.82306760
109positive regulation of DNA-dependent DNA replication (GO:2000105)2.82066846
110regulation of histone methylation (GO:0031060)2.81051858
111regulation of centriole replication (GO:0046599)2.80846733
112intracellular estrogen receptor signaling pathway (GO:0030520)2.80677246
113striated muscle hypertrophy (GO:0014897)2.80297470
114establishment of mitotic spindle localization (GO:0040001)2.79519983
115regulation of chromosome segregation (GO:0051983)2.79352658
116corticosteroid receptor signaling pathway (GO:0031958)2.77979557
117carnitine shuttle (GO:0006853)2.77644231
118spindle assembly involved in mitosis (GO:0090307)2.77361175
119regulation of nucleobase-containing compound transport (GO:0032239)2.75020333
120regulation of telomere maintenance via telomerase (GO:0032210)2.74639785
121attachment of spindle microtubules to kinetochore (GO:0008608)2.74499085
122gene silencing (GO:0016458)2.73695334
123DNA damage response, signal transduction resulting in transcription (GO:0042772)2.72988198
124negative regulation of histone modification (GO:0031057)2.72538970
125mitotic G1 DNA damage checkpoint (GO:0031571)2.72462962
126regulation of centrosome cycle (GO:0046605)2.72227983
127TOR signaling (GO:0031929)2.70457869
128translesion synthesis (GO:0019985)2.68732230
129spliceosomal tri-snRNP complex assembly (GO:0000244)2.68611848
130negative regulation of chromatin modification (GO:1903309)2.68316841
131spindle assembly (GO:0051225)2.68028949
132chromatin silencing (GO:0006342)2.67891081
133somatic hypermutation of immunoglobulin genes (GO:0016446)2.67144244
134somatic diversification of immune receptors via somatic mutation (GO:0002566)2.67144244
135regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.66688475
136gene silencing by RNA (GO:0031047)2.66209907
137DNA strand elongation (GO:0022616)2.66100437
138negative regulation of gene expression, epigenetic (GO:0045814)2.65803308
139positive regulation of histone deacetylation (GO:0031065)2.65180362
140DNA replication-independent nucleosome organization (GO:0034724)2.65133309
141DNA replication-independent nucleosome assembly (GO:0006336)2.65133309
142positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.64877108
143paraxial mesoderm development (GO:0048339)2.63892876
144cardiac muscle contraction (GO:0060048)2.63669860
145muscle atrophy (GO:0014889)2.63457348
146N-terminal protein amino acid acetylation (GO:0006474)2.62931344
147chromosome segregation (GO:0007059)2.62131646
148regulation of centrosome duplication (GO:0010824)2.61730475
1493-UTR-mediated mRNA stabilization (GO:0070935)2.61634559
150regulation of mRNA stability (GO:0043488)2.61516605
151peptidyl-lysine dimethylation (GO:0018027)2.60376565
152negative regulation of potassium ion transmembrane transport (GO:1901380)2.60301886
153protein K6-linked ubiquitination (GO:0085020)2.60196347
154regulation of translational termination (GO:0006449)2.59793461
155positive regulation of gene expression, epigenetic (GO:0045815)2.59738797
156positive regulation of histone H3-K4 methylation (GO:0051571)2.59209591
157cytoplasmic mRNA processing body assembly (GO:0033962)2.57474461
158regulation of hippo signaling (GO:0035330)2.57419644
159mRNA transport (GO:0051028)2.56882212
160ATP-dependent chromatin remodeling (GO:0043044)2.56819683
161nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.56242678
162mitotic recombination (GO:0006312)2.55661151

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.56425985
2* FOXM1_23109430_ChIP-Seq_U2OS_Human5.77273254
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.68631544
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.40503611
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.05637968
6MYC_22102868_ChIP-Seq_BL_Human2.85656748
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.37877380
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.33061910
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.20614250
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.18553725
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.16872996
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.16135950
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.15824278
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.06979094
15AR_21909140_ChIP-Seq_LNCAP_Human2.06283359
16* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.04528590
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.99669411
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.98360008
19PKCTHETA_26484144_Chip-Seq_BREAST_Human1.93531704
20VDR_21846776_ChIP-Seq_THP-1_Human1.87762739
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.81014844
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.77615842
23DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.71046626
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.70817128
25TCF7_22412390_ChIP-Seq_EML_Mouse1.70764331
26CIITA_25753668_ChIP-Seq_RAJI_Human1.70351598
27STAT3_1855785_ChIP-Seq_MESCs_Mouse1.69121273
28* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.67160402
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.66922045
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63710338
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.56679323
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.55949399
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55486053
34POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53666806
35ZNF263_19887448_ChIP-Seq_K562_Human1.53072166
36FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.52630976
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50644633
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.49478950
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44797383
40BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.43118389
41* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42880305
42KDM2B_26808549_Chip-Seq_JURKAT_Human1.39505490
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39063709
44* KDM2B_26808549_Chip-Seq_DND41_Human1.38758634
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37198944
46KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.36554281
47KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.36554281
48KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.36554281
49* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35312360
50TBX20_22080862_ChIP-Seq_HEART_Mouse1.34934722
51TBX20_22328084_ChIP-Seq_HEART_Mouse1.34934722
52ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.34703057
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34369409
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33415348
55MAF_26560356_Chip-Seq_TH1_Human1.32268776
56XRN2_22483619_ChIP-Seq_HELA_Human1.30953501
57RARB_27405468_Chip-Seq_BRAIN_Mouse1.29424357
58GATA4_21415370_ChIP-Seq_HL-1_Mouse1.29165626
59GATA1_19941826_ChIP-Seq_K562_Human1.28484114
60UTX_26944678_Chip-Seq_JUKART_Human1.28116087
61CTNNB1_20460455_ChIP-Seq_HCT116_Human1.28032298
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.27091147
63CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.25686268
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23722923
65MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22291712
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.22132505
67KDM5A_27292631_Chip-Seq_BREAST_Human1.21963368
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20401392
69P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19981122
70* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19097668
71* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18917357
72ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18638902
73NANOG_21062744_ChIP-ChIP_HESCs_Human1.18626012
74STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.16433477
75CREB1_26743006_Chip-Seq_LNCaP_Human1.15924783
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15861246
77ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15398979
78SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.14824100
79GATA1_22025678_ChIP-Seq_K562_Human1.14645215
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.13988481
81NCOR1_26117541_ChIP-Seq_K562_Human1.13599745
82RACK7_27058665_Chip-Seq_MCF-7_Human1.12928178
83* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12631740
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11792639
85* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11409956
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10949157
87TCF3_18692474_ChIP-Seq_MEFs_Mouse1.10317296
88STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10289268
89* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10239199
90NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09987761
91KDM2B_26808549_Chip-Seq_K562_Human1.09627796
92KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09411315
93MYB_26560356_Chip-Seq_TH1_Human1.09266092
94PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09216537
95SCL_19346495_ChIP-Seq_HPC-7_Human1.09137195
96TCF3_18692474_ChIP-Seq_MESCs_Mouse1.08140799
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07849552
98KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05965039
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05844557
100DROSHA_22980978_ChIP-Seq_HELA_Human1.05534566
101* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04742679
102ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04409469
103RUNX1_27514584_Chip-Seq_MCF-7_Human1.03928450
104BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03875136
105TFEB_21752829_ChIP-Seq_HELA_Human1.03514280
106NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.01253267
107MYB_26560356_Chip-Seq_TH2_Human1.00646306
108TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00035635
109MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.99972695
110SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99098779
111SMC4_20622854_ChIP-Seq_HELA_Human0.98212887
112GATA2_19941826_ChIP-Seq_K562_Human0.97596310
113NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97521788
114FOXP3_21729870_ChIP-Seq_TREG_Human0.96587684
115* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96180878
116NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.95710801
117ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95560460
118ATF3_27146783_Chip-Seq_COLON_Human0.95321563
119GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95140105
120CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92491515
121KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91700119
122* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90768318
123* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90064137
124CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89441060
125VDR_23849224_ChIP-Seq_CD4+_Human0.88868950
126MYB_21317192_ChIP-Seq_ERMYB_Mouse0.88144126
127E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87978002
128RUNX1_22412390_ChIP-Seq_EML_Mouse0.87642230
129TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87028349
130HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86801756
131CHD1_26751641_Chip-Seq_LNCaP_Human0.86080857
132NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.85762191
133E2F1_17053090_ChIP-ChIP_MCF-7_Human0.85434758
134P68_20966046_ChIP-Seq_HELA_Human0.85177341
135MAF_26560356_Chip-Seq_TH2_Human0.84268480
136SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.84205903
137NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84070670
138PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83920514
139SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.83334730
140SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82724165
141GATA6_25053715_ChIP-Seq_YYC3_Human0.82295464
142TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.82289067
143SOX2_18692474_ChIP-Seq_MESCs_Mouse0.82192081
144E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.81825546
145NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.81584409
146FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.81533026
147VDR_24763502_ChIP-Seq_THP-1_Human0.81285651
148MITF_21258399_ChIP-Seq_MELANOMA_Human0.79327022

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.33974398
2MP0003111_abnormal_nucleus_morphology3.33755060
3MP0003693_abnormal_embryo_hatching3.11246229
4MP0008057_abnormal_DNA_replication3.02159582
5MP0005451_abnormal_body_composition2.97221745
6MP0003077_abnormal_cell_cycle2.89784804
7MP0004957_abnormal_blastocyst_morpholog2.78371385
8MP0003705_abnormal_hypodermis_morpholog2.78026307
9MP0010352_gastrointestinal_tract_polyps2.75779060
10MP0000747_muscle_weakness2.43021054
11MP0005076_abnormal_cell_differentiation2.37203835
12MP0010307_abnormal_tumor_latency2.21971085
13MP0001730_embryonic_growth_arrest2.15591124
14MP0002396_abnormal_hematopoietic_system2.06729404
15MP0002332_abnormal_exercise_endurance2.01368103
16MP0000350_abnormal_cell_proliferation2.00371841
17MP0004130_abnormal_muscle_cell1.95159824
18MP0002009_preneoplasia1.92844739
19MP0005380_embryogenesis_phenotype1.92369175
20MP0001672_abnormal_embryogenesis/_devel1.92369175
21MP0009278_abnormal_bone_marrow1.91592802
22MP0003984_embryonic_growth_retardation1.83898640
23MP0004084_abnormal_cardiac_muscle1.83525825
24MP0002088_abnormal_embryonic_growth/wei1.80767021
25MP0004808_abnormal_hematopoietic_stem1.76035857
26MP0001661_extended_life_span1.73227742
27MP0008877_abnormal_DNA_methylation1.71839804
28MP0002086_abnormal_extraembryonic_tissu1.68651090
29MP0003566_abnormal_cell_adhesion1.68229057
30MP0008058_abnormal_DNA_repair1.67117907
31MP0002084_abnormal_developmental_patter1.66828470
32MP0004197_abnormal_fetal_growth/weight/1.64094420
33MP0001697_abnormal_embryo_size1.63724161
34MP0008007_abnormal_cellular_replicative1.56583682
35MP0003646_muscle_fatigue1.54709490
36MP0002085_abnormal_embryonic_tissue1.54070637
37MP0010630_abnormal_cardiac_muscle1.52082340
38MP0003656_abnormal_erythrocyte_physiolo1.51790313
39MP0002080_prenatal_lethality1.45570976
40MP0003567_abnormal_fetal_cardiomyocyte1.45201874
41MP0000003_abnormal_adipose_tissue1.42164401
42MP0005266_abnormal_metabolism1.40180513
43MP0004087_abnormal_muscle_fiber1.40010925
44MP0002108_abnormal_muscle_morphology1.38294068
45MP0000733_abnormal_muscle_development1.36751251
46MP0005620_abnormal_muscle_contractility1.34967018
47MP0003828_pulmonary_edema1.34782636
48MP0004185_abnormal_adipocyte_glucose1.32588226
49MP0001545_abnormal_hematopoietic_system1.32408271
50MP0005397_hematopoietic_system_phenotyp1.32408271
51MP0000569_abnormal_digit_pigmentation1.28089154
52MP0000013_abnormal_adipose_tissue1.27217203
53MP0009780_abnormal_chondrocyte_physiolo1.25874427
54MP0008932_abnormal_embryonic_tissue1.25602627
55MP0002269_muscular_atrophy1.24975206
56MP0000750_abnormal_muscle_regeneration1.24375845
57MP0003300_gastrointestinal_ulcer1.22268252
58MP0004264_abnormal_extraembryonic_tissu1.22246612
59MP0000751_myopathy1.21408687
60MP0004145_abnormal_muscle_electrophysio1.21340003
61MP0002877_abnormal_melanocyte_morpholog1.18384245
62MP0000313_abnormal_cell_death1.16392478
63MP0000490_abnormal_crypts_of1.15376662
64MP0000703_abnormal_thymus_morphology1.14706320
65MP0002019_abnormal_tumor_incidence1.13273644
66MP0002925_abnormal_cardiovascular_devel1.13012404
67MP0001849_ear_inflammation1.09464159
68MP0003123_paternal_imprinting1.09458899
69MP0002106_abnormal_muscle_physiology1.08966656
70MP0000266_abnormal_heart_morphology1.08347837
71MP0003121_genomic_imprinting1.08004816
72MP0005330_cardiomyopathy1.07256040
73MP0004272_abnormal_basement_membrane1.05972541
74MP0005023_abnormal_wound_healing1.03940011
75MP0003763_abnormal_thymus_physiology1.03273540
76MP0004233_abnormal_muscle_weight1.03270767
77MP0003786_premature_aging1.03170769
78MP0003279_aneurysm1.02682933
79MP0001915_intracranial_hemorrhage1.00750686
80MP0003045_fibrosis0.99755887
81MP0002127_abnormal_cardiovascular_syste0.99420764
82MP0005375_adipose_tissue_phenotype0.97530874
83MP0002398_abnormal_bone_marrow0.95892982
84MP0000749_muscle_degeneration0.95856044
85MP0004270_analgesia0.95730018
86MP0006138_congestive_heart_failure0.95170751
87MP0002166_altered_tumor_susceptibility0.94289197
88MP0003890_abnormal_embryonic-extraembry0.93798693
89MP0004036_abnormal_muscle_relaxation0.92834355
90MP0006036_abnormal_mitochondrial_physio0.92025334
91MP0009672_abnormal_birth_weight0.91036622
92MP0001293_anophthalmia0.90943520
93MP0005666_abnormal_adipose_tissue0.90290903
94MP0009703_decreased_birth_body0.89920164
95MP0005623_abnormal_meninges_morphology0.89044041
96MP0008995_early_reproductive_senescence0.89033889
97MP0000759_abnormal_skeletal_muscle0.88248640
98MP0002722_abnormal_immune_system0.87931191
99MP0010368_abnormal_lymphatic_system0.87548968
100MP0005621_abnormal_cell_physiology0.86536051
101MP0002114_abnormal_axial_skeleton0.84469893
102MP0003787_abnormal_imprinting0.82924171
103MP0002972_abnormal_cardiac_muscle0.81515990
104MP0003221_abnormal_cardiomyocyte_apopto0.80585053
105MP0002837_dystrophic_cardiac_calcinosis0.80567387
106MP0000689_abnormal_spleen_morphology0.79446987
107MP0003091_abnormal_cell_migration0.78772683
108MP0003115_abnormal_respiratory_system0.78624426
109MP0001346_abnormal_lacrimal_gland0.78585585
110MP0004215_abnormal_myocardial_fiber0.77953808
111MP0003941_abnormal_skin_development0.77885739
112MP0003119_abnormal_digestive_system0.77604245
113MP0002971_abnormal_brown_adipose0.75963303
114MP0008961_abnormal_basal_metabolism0.75479121
115MP0000428_abnormal_craniofacial_morphol0.75116459
116MP0001784_abnormal_fluid_regulation0.74969517
117MP0005369_muscle_phenotype0.74627202
118MP0004133_heterotaxia0.74501149
119MP0000371_diluted_coat_color0.74270534
120MP0003950_abnormal_plasma_membrane0.73970610
121MP0003935_abnormal_craniofacial_develop0.73642612
122MP0005384_cellular_phenotype0.72982806
123MP0010234_abnormal_vibrissa_follicle0.72360378
124MP0001544_abnormal_cardiovascular_syste0.71867648
125MP0002970_abnormal_white_adipose0.71831743
126MP0000015_abnormal_ear_pigmentation0.67161591
127MP0001348_abnormal_lacrimal_gland0.65845645
128MP0005645_abnormal_hypothalamus_physiol0.64484421
129MP0005670_abnormal_white_adipose0.63833304
130MP0009697_abnormal_copulation0.63421553
131MP0002249_abnormal_larynx_morphology0.63164797
132MP0004381_abnormal_hair_follicle0.62180135
133MP0005409_darkened_coat_color0.61419408
134MP0005187_abnormal_penis_morphology0.60597113
135MP0000383_abnormal_hair_follicle0.57190326

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)7.62732205
2Nemaline bodies (HP:0003798)7.58619779
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.52326102
4Exercise-induced myalgia (HP:0003738)6.25562950
5Type 1 muscle fiber predominance (HP:0003803)5.60367391
6Myopathic facies (HP:0002058)4.64910922
7Muscle hypertrophy of the lower extremities (HP:0008968)3.87213271
8Distal arthrogryposis (HP:0005684)3.81818736
9Ependymoma (HP:0002888)3.79838599
10Centrally nucleated skeletal muscle fibers (HP:0003687)3.76468697
11EMG: myopathic abnormalities (HP:0003458)3.67548563
12Calf muscle hypertrophy (HP:0008981)3.62024428
13Neoplasm of the oral cavity (HP:0100649)3.57169691
14Abnormality of the fingertips (HP:0001211)3.37339110
15Calcaneovalgus deformity (HP:0001848)3.30768676
16Chromsome breakage (HP:0040012)3.18459159
17Increased connective tissue (HP:0009025)3.16210837
18Round ear (HP:0100830)3.00300620
19Abnormality of skeletal muscle fiber size (HP:0012084)2.99056803
20Long eyelashes (HP:0000527)2.97643362
21Abnormality of the calf musculature (HP:0001430)2.96276612
22Frequent falls (HP:0002359)2.92728713
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.90322593
24Ulnar deviation of the wrist (HP:0003049)2.88092511
25Neck muscle weakness (HP:0000467)2.87637222
26Hyperkalemia (HP:0002153)2.78626073
27Abnormality of the astrocytes (HP:0100707)2.77931198
28Astrocytoma (HP:0009592)2.77931198
29Deformed tarsal bones (HP:0008119)2.77908116
30Myoglobinuria (HP:0002913)2.76025876
31Increased variability in muscle fiber diameter (HP:0003557)2.75467257
32Volvulus (HP:0002580)2.71154742
33Dysmetric saccades (HP:0000641)2.70412216
34Rimmed vacuoles (HP:0003805)2.70370907
35Rhabdomyolysis (HP:0003201)2.69681777
36Skull defect (HP:0001362)2.68884237
37Medulloblastoma (HP:0002885)2.61310922
38Hyporeflexia of lower limbs (HP:0002600)2.61002560
39Wrist flexion contracture (HP:0001239)2.54420460
40Areflexia of lower limbs (HP:0002522)2.49572080
41Selective tooth agenesis (HP:0001592)2.48278717
42Increased nuchal translucency (HP:0010880)2.47638561
43Difficulty running (HP:0009046)2.46704809
44Biliary tract neoplasm (HP:0100574)2.45692646
45Ventricular tachycardia (HP:0004756)2.44726727
46Progressive muscle weakness (HP:0003323)2.44543332
47Generalized muscle weakness (HP:0003324)2.41738393
48* Truncal obesity (HP:0001956)2.39632201
49Rhabdomyosarcoma (HP:0002859)2.38330485
50* Prominent nose (HP:0000448)2.38192694
51Hyperacusis (HP:0010780)2.36557474
52Muscle fiber splitting (HP:0003555)2.36428878
53* High pitched voice (HP:0001620)2.35025739
54Impulsivity (HP:0100710)2.34285201
55Protrusio acetabuli (HP:0003179)2.31176625
56Short 4th metacarpal (HP:0010044)2.28256086
57Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.28256086
58Fetal akinesia sequence (HP:0001989)2.27233344
59Glioma (HP:0009733)2.26020977
60Abnormality of chromosome stability (HP:0003220)2.25289591
61Ectopic kidney (HP:0000086)2.24520930
62Urethral obstruction (HP:0000796)2.23505676
63Basal cell carcinoma (HP:0002671)2.21885867
64Hypoplastic ischia (HP:0003175)2.21589672
65Subaortic stenosis (HP:0001682)2.21113383
66Abnormality of the left ventricular outflow tract (HP:0011103)2.21113383
67Bundle branch block (HP:0011710)2.20635029
68Heterotopia (HP:0002282)2.20507378
69Lower limb amyotrophy (HP:0007210)2.20488769
70Neoplasm of striated muscle (HP:0009728)2.19906159
71Deviation of the thumb (HP:0009603)2.19842738
72Exercise-induced muscle cramps (HP:0003710)2.18327353
73Proximal placement of thumb (HP:0009623)2.16073016
74Difficulty climbing stairs (HP:0003551)2.15484008
75Gastrointestinal carcinoma (HP:0002672)2.14580035
76Malignant gastrointestinal tract tumors (HP:0006749)2.14580035
77Malignant hyperthermia (HP:0002047)2.12339247
78Muscle stiffness (HP:0003552)2.11892981
79Broad palm (HP:0001169)2.09873317
80Distal lower limb muscle weakness (HP:0009053)2.09673887
81Mildly elevated creatine phosphokinase (HP:0008180)2.07857444
82Abnormality of the ischium (HP:0003174)2.07552063
83Colon cancer (HP:0003003)2.07438169
84* Cafe-au-lait spot (HP:0000957)1.99759153
85Myelodysplasia (HP:0002863)1.96246720
86Low anterior hairline (HP:0000294)1.96116805
87Abnormality of the labia minora (HP:0012880)1.95094004
88Trismus (HP:0000211)1.94902030
89Shallow orbits (HP:0000586)1.94036071
90Obsessive-compulsive behavior (HP:0000722)1.91645278
91Vertebral arch anomaly (HP:0008438)1.90943779
92Sudden death (HP:0001699)1.90650836
93Ankle contracture (HP:0006466)1.90341931
94Proximal amyotrophy (HP:0007126)1.90132529
95* Sandal gap (HP:0001852)1.90032491
96Absent phalangeal crease (HP:0006109)1.88339053
97Anal stenosis (HP:0002025)1.88205773
98Macroorchidism (HP:0000053)1.85177829
99Neonatal death (HP:0003811)1.84535978
100Patellar aplasia (HP:0006443)1.84517499
101Rib fusion (HP:0000902)1.84181764
102Aplasia/Hypoplasia of the uvula (HP:0010293)1.83706736
103Abnormality of the salivary glands (HP:0010286)1.82323470
104Agnosia (HP:0010524)1.81945314
105Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.81663370
106Hip contracture (HP:0003273)1.80858661
107Lip pit (HP:0100267)1.80579198
108Acute myeloid leukemia (HP:0004808)1.79070186
109Aplasia/Hypoplasia of the sternum (HP:0006714)1.78874714
110Skin tags (HP:0010609)1.77241107
111Meckel diverticulum (HP:0002245)1.76702133
112Scapular winging (HP:0003691)1.76237620
113Birth length less than 3rd percentile (HP:0003561)1.75956558
114Supernumerary ribs (HP:0005815)1.75584494
115Ragged-red muscle fibers (HP:0003200)1.74664165
116Vertebral clefting (HP:0008428)1.74275628
117Increased density of long bones (HP:0006392)1.73716704
118Facial hemangioma (HP:0000329)1.72096484
119Dislocated radial head (HP:0003083)1.71650520
120Abnormality of the preputium (HP:0100587)1.70850779
121Broad face (HP:0000283)1.70622095
122Abnormality of the 4th metacarpal (HP:0010012)1.70346420
123Abnormality of the carotid arteries (HP:0005344)1.70082540
124Myotonia (HP:0002486)1.70065812
125Muscular dystrophy (HP:0003560)1.69042156
126Short humerus (HP:0005792)1.67467627
127Amaurosis fugax (HP:0100576)1.67419869
128Abnormality of the ileum (HP:0001549)1.67140597
129EMG: neuropathic changes (HP:0003445)1.67129873
130Missing ribs (HP:0000921)1.66942880
131Sparse lateral eyebrow (HP:0005338)1.66935083
132Abnormal number of incisors (HP:0011064)1.66720995
133Cutis marmorata (HP:0000965)1.66706373
134Aplasia/Hypoplasia of the patella (HP:0006498)1.66201058
135Hematochezia (HP:0002573)1.65683934
136Small intestinal stenosis (HP:0012848)1.64832666
137Duodenal stenosis (HP:0100867)1.64832666
138Abnormality of the calcaneus (HP:0008364)1.64448706
139Shawl scrotum (HP:0000049)1.64156214
140Distal lower limb amyotrophy (HP:0008944)1.62381589
141Deep philtrum (HP:0002002)1.62244206
142Spinal rigidity (HP:0003306)1.61666009
143Depressed nasal tip (HP:0000437)1.59991745
144Ovarian neoplasm (HP:0100615)1.59893211
145Abnormal finger flexion creases (HP:0006143)1.59077337
146Uterine neoplasm (HP:0010784)1.58954874
147Abnormality of chromosome segregation (HP:0002916)1.58824971
148Lipoatrophy (HP:0100578)1.58767009
149Renovascular hypertension (HP:0100817)1.58697616
150High anterior hairline (HP:0009890)1.57848112
151Dilated cardiomyopathy (HP:0001644)1.57830892
152Obstructive sleep apnea (HP:0002870)1.57476866
153Preauricular skin tag (HP:0000384)1.57250395
154Spinal muscular atrophy (HP:0007269)1.56794246
155Asymmetric septal hypertrophy (HP:0001670)1.56229382
156Abnormality of the foot musculature (HP:0001436)1.56073521
157Duplicated collecting system (HP:0000081)1.55877200
158Abnormality of the parathyroid morphology (HP:0011766)1.55165675
159Abnormality of the radial head (HP:0003995)1.53841566
160Foot dorsiflexor weakness (HP:0009027)1.53182844
161Hypopigmentation of the fundus (HP:0007894)1.52557856
162Abnormality of DNA repair (HP:0003254)1.51566569
163Abnormality of the columella (HP:0009929)1.51348677
164Paralysis (HP:0003470)1.51332194
165Congenital hip dislocation (HP:0001374)1.50356912
166Fatigable weakness (HP:0003473)1.50002697
167Abnormality of the neuromuscular junction (HP:0003398)1.50002697
168Germ cell neoplasia (HP:0100728)1.48619576
169Bowel incontinence (HP:0002607)1.48095473
170Narrow palate (HP:0000189)1.47352808
171Bulbar palsy (HP:0001283)1.47049734
172Cystic hygroma (HP:0000476)1.46926240

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.93548310
2EEF2K3.35799820
3CDC73.33569666
4NEK23.11369306
5PHKG13.06883188
6PHKG23.06883188
7TTN3.03657706
8MAP3K102.70234424
9SCYL22.55004866
10PKN22.54011320
11TTK2.23745802
12TRIB32.15396171
13STK102.06939864
14SMG11.86158297
15RPS6KB21.84401432
16LATS11.74017053
17WEE11.73559482
18CDK41.71469128
19NEK11.70136334
20MAP3K91.69928558
21STK41.67687105
22MAP4K11.63963218
23BRD41.61647921
24PIK3CG1.51020484
25MTOR1.35479275
26AURKB1.29856668
27ATR1.29240806
28ICK1.27723959
29MAP3K81.23804730
30CCNB11.23380913
31EPHA21.23264366
32CDK71.23111991
33ALK1.22541295
34CHEK11.21532416
35DMPK1.21489555
36BUB11.20313718
37CAMK1D1.18695787
38* PLK11.15829260
39STK31.14541892
40CDK61.13950104
41SGK31.13074424
42SIK21.11881308
43CHEK21.10371875
44PTK61.07008398
45MARK21.05246320
46MAP2K31.04312440
47RIPK11.03472121
48PRKAA21.01537684
49TIE11.00033593
50MARK10.99912389
51FLT30.99147319
52PDK30.96698187
53PDK40.96698187
54SGK20.96411520
55LRRK20.95765336
56PAK40.93831154
57ATM0.93307589
58MAPK120.91384133
59CAMK40.88269008
60PRPF4B0.87437793
61PIM10.86316935
62MAPKAPK30.85785151
63CDK20.83859127
64ZAK0.83363381
65GRK60.82067120
66CAMK1G0.80719245
67PASK0.80163263
68STK390.79467507
69CLK10.78182879
70OBSCN0.77407674
71MELK0.77087934
72SRPK10.72605600
73TNK20.71678311
74PDGFRA0.71292635
75CDK90.70987785
76TSSK60.70810171
77MAPK100.70064045
78WNK10.67469290
79GSK3B0.66260856
80WNK40.66182221
81TGFBR10.65091678
82TLK10.64052573
83MAP3K130.63422612
84MAP2K40.63020299
85FGFR20.62519689
86MAP3K70.61778126
87RPS6KA40.61649261
88KSR20.60768185
89PLK40.59483467
90LATS20.58034439
91CDK10.57363072
92FGFR30.57267632
93RPS6KB10.56538233
94BRAF0.55781341
95AKT20.54852487
96RPS6KC10.54664220
97RPS6KL10.54664220
98TYK20.54335926
99PDGFRB0.54082048
100JAK30.52855461
101CSNK1D0.52169965
102TRPM70.51906628
103CSF1R0.51617725
104TGFBR20.51039219
105CHUK0.51015081
106DYRK30.50876016
107SGK10.50796210
108MKNK20.50421030
109EIF2AK10.49432306
110MAP2K10.49100671
111BRSK20.48396445
112RPS6KA30.48381510
113MARK30.48017432
114PRKDC0.46699412
115RAF10.46296491
116FGFR40.46263910
117PAK20.45414892
118MAPK80.45378174
119PLK30.44475412
120TAOK30.44288863
121RPS6KA60.44128215
122STK240.43739828
123SGK4940.43034590
124SGK2230.43034590
125FRK0.42906898
126MAPK140.42555331
127NEK90.42515875
128BRSK10.42402094
129BMX0.41915630
130MUSK0.41846701
131PRKAA10.41636891
132HIPK20.39788877
133NME10.39066407
134CAMK10.38924719
135RPS6KA10.38484116
136MAPK10.38041604
137SIK10.37693934
138NEK60.37323495
139AURKA0.37144245
140TYRO30.36897042
141MKNK10.36895656
142ZAP700.36581707
143RPS6KA20.36530085
144AKT10.35833177
145PNCK0.35360514
146ITK0.34247041
147MAPK110.33669010
148CSK0.33237176

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.32666430
2Mismatch repair_Homo sapiens_hsa034303.16953351
3RNA transport_Homo sapiens_hsa030132.52087086
4Cell cycle_Homo sapiens_hsa041102.49471577
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.33318258
6Spliceosome_Homo sapiens_hsa030402.16114875
7Base excision repair_Homo sapiens_hsa034102.11848565
8One carbon pool by folate_Homo sapiens_hsa006702.08440684
9Homologous recombination_Homo sapiens_hsa034402.07582776
10Fanconi anemia pathway_Homo sapiens_hsa034601.96030529
11mRNA surveillance pathway_Homo sapiens_hsa030151.95509293
12Non-homologous end-joining_Homo sapiens_hsa034501.87180720
13Small cell lung cancer_Homo sapiens_hsa052221.76667313
14Systemic lupus erythematosus_Homo sapiens_hsa053221.73033299
15Lysine degradation_Homo sapiens_hsa003101.69862684
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.64033138
17Nucleotide excision repair_Homo sapiens_hsa034201.58108992
18p53 signaling pathway_Homo sapiens_hsa041151.54610147
19RNA degradation_Homo sapiens_hsa030181.52320441
20MicroRNAs in cancer_Homo sapiens_hsa052061.48069269
21Viral carcinogenesis_Homo sapiens_hsa052031.47098375
22Glioma_Homo sapiens_hsa052141.44498504
23Viral myocarditis_Homo sapiens_hsa054161.42107334
24Circadian rhythm_Homo sapiens_hsa047101.38486054
25mTOR signaling pathway_Homo sapiens_hsa041501.34364795
26Chronic myeloid leukemia_Homo sapiens_hsa052201.32063966
27Notch signaling pathway_Homo sapiens_hsa043301.29727293
28Adherens junction_Homo sapiens_hsa045201.23665784
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.22717675
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.21803838
31HTLV-I infection_Homo sapiens_hsa051661.21224032
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19829845
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.17973174
34Herpes simplex infection_Homo sapiens_hsa051681.15368569
35Antigen processing and presentation_Homo sapiens_hsa046121.12931465
36Long-term potentiation_Homo sapiens_hsa047201.12392363
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09699956
38Type II diabetes mellitus_Homo sapiens_hsa049301.09623360
39Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08520903
40ErbB signaling pathway_Homo sapiens_hsa040121.05467119
41Oxytocin signaling pathway_Homo sapiens_hsa049211.05290016
42Adipocytokine signaling pathway_Homo sapiens_hsa049201.05073625
43ECM-receptor interaction_Homo sapiens_hsa045121.01213709
44Primary immunodeficiency_Homo sapiens_hsa053401.00557546
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.00158632
46Renal cell carcinoma_Homo sapiens_hsa052111.00129316
47Pentose phosphate pathway_Homo sapiens_hsa000300.99745985
48Epstein-Barr virus infection_Homo sapiens_hsa051690.98712116
49Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.97630443
50GnRH signaling pathway_Homo sapiens_hsa049120.97035235
51Acute myeloid leukemia_Homo sapiens_hsa052210.96737503
52Calcium signaling pathway_Homo sapiens_hsa040200.96009117
53Fructose and mannose metabolism_Homo sapiens_hsa000510.95619875
54Oocyte meiosis_Homo sapiens_hsa041140.95614647
55B cell receptor signaling pathway_Homo sapiens_hsa046620.94409246
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.93692139
57Focal adhesion_Homo sapiens_hsa045100.93238391
58Non-small cell lung cancer_Homo sapiens_hsa052230.92226453
59Toxoplasmosis_Homo sapiens_hsa051450.91742365
60Proteoglycans in cancer_Homo sapiens_hsa052050.90406087
61Dilated cardiomyopathy_Homo sapiens_hsa054140.90375304
62Insulin resistance_Homo sapiens_hsa049310.89918790
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.86822721
64Colorectal cancer_Homo sapiens_hsa052100.85257285
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84349242
66Choline metabolism in cancer_Homo sapiens_hsa052310.83605252
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82594846
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82430684
69Apoptosis_Homo sapiens_hsa042100.82202549
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81380348
71Thyroid cancer_Homo sapiens_hsa052160.80797373
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80783672
73HIF-1 signaling pathway_Homo sapiens_hsa040660.80700472
74Prolactin signaling pathway_Homo sapiens_hsa049170.80204522
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80047226
76RNA polymerase_Homo sapiens_hsa030200.79334537
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.79313147
78Dorso-ventral axis formation_Homo sapiens_hsa043200.77887931
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76413204
80Pathways in cancer_Homo sapiens_hsa052000.75963523
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75876710
82Estrogen signaling pathway_Homo sapiens_hsa049150.75577701
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75474811
84Pancreatic cancer_Homo sapiens_hsa052120.74929617
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73864842
86Hippo signaling pathway_Homo sapiens_hsa043900.73769400
87Selenocompound metabolism_Homo sapiens_hsa004500.73706398
88Hepatitis B_Homo sapiens_hsa051610.73535891
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72924829
90Pyrimidine metabolism_Homo sapiens_hsa002400.72827575
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72651849
92FoxO signaling pathway_Homo sapiens_hsa040680.70556287
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70481839
94Tight junction_Homo sapiens_hsa045300.70326970
95AMPK signaling pathway_Homo sapiens_hsa041520.69666563
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69090036
97Basal cell carcinoma_Homo sapiens_hsa052170.68059872
98Measles_Homo sapiens_hsa051620.67573767
99Basal transcription factors_Homo sapiens_hsa030220.67103236
100Endometrial cancer_Homo sapiens_hsa052130.64675652
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64345367
102Melanogenesis_Homo sapiens_hsa049160.63588516
103TGF-beta signaling pathway_Homo sapiens_hsa043500.63506666
104Insulin signaling pathway_Homo sapiens_hsa049100.63468569
105Insulin secretion_Homo sapiens_hsa049110.62370518
106Influenza A_Homo sapiens_hsa051640.62296072
107Biosynthesis of amino acids_Homo sapiens_hsa012300.61581963
108Cholinergic synapse_Homo sapiens_hsa047250.61575942
109VEGF signaling pathway_Homo sapiens_hsa043700.61199708
110Platelet activation_Homo sapiens_hsa046110.60726374
111T cell receptor signaling pathway_Homo sapiens_hsa046600.60314014
112ABC transporters_Homo sapiens_hsa020100.57393680
113Long-term depression_Homo sapiens_hsa047300.57123069
114Melanoma_Homo sapiens_hsa052180.56981605
115Amoebiasis_Homo sapiens_hsa051460.56277248
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56025860
117Glucagon signaling pathway_Homo sapiens_hsa049220.55933974
118Inositol phosphate metabolism_Homo sapiens_hsa005620.55894163
119Prostate cancer_Homo sapiens_hsa052150.55658841
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55279424
121Wnt signaling pathway_Homo sapiens_hsa043100.54314535
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.53979994
123MAPK signaling pathway_Homo sapiens_hsa040100.53192882
124Gastric acid secretion_Homo sapiens_hsa049710.52755392
125Bladder cancer_Homo sapiens_hsa052190.51269811
126Alcoholism_Homo sapiens_hsa050340.50525924
127Osteoclast differentiation_Homo sapiens_hsa043800.49776503
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.49285867
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48815624
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.47625079
131Carbon metabolism_Homo sapiens_hsa012000.47415415
132Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47017903
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.46442053
134Ribosome_Homo sapiens_hsa030100.45956642
135NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43608705
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42996763

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