PCNX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an evolutionarily conserved transmembrane protein similar to the pecanex protein in Drosophila. The fly protein is a component of the Notch signaling pathway, which functions in several developmental processes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.08591869
2detection of molecule of bacterial origin (GO:0032490)4.53069494
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.44277907
4negative regulation of cell killing (GO:0031342)4.44277907
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.07458384
6cellular extravasation (GO:0045123)3.90590558
7regulation of gamma-delta T cell activation (GO:0046643)3.88898341
8positive regulation by symbiont of host defense response (GO:0052509)3.85887469
9modulation by symbiont of host defense response (GO:0052031)3.85887469
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.85887469
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.85887469
12positive regulation by organism of defense response of other organism involved in symbiotic interact3.85887469
13modulation by symbiont of host immune response (GO:0052553)3.85887469
14regulation of B cell receptor signaling pathway (GO:0050855)3.85210589
15regulation of gamma-delta T cell differentiation (GO:0045586)3.75541312
16positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.64871653
17macrophage activation involved in immune response (GO:0002281)3.61138989
18phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.54724502
19histone H3-K36 demethylation (GO:0070544)3.46496746
20response to interleukin-15 (GO:0070672)3.45799128
21cellular response to ethanol (GO:0071361)3.39117298
22detection of external biotic stimulus (GO:0098581)3.38986371
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.32208579
24B cell receptor signaling pathway (GO:0050853)3.22958574
25negative regulation of T cell mediated immunity (GO:0002710)3.22182362
26negative regulation of interleukin-12 production (GO:0032695)3.19506668
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.14750665
28detection of other organism (GO:0098543)3.14091510
29negative T cell selection (GO:0043383)3.10354148
30microglial cell activation (GO:0001774)3.07768050
31antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.07534401
32negative thymic T cell selection (GO:0045060)3.07393417
33positive T cell selection (GO:0043368)3.03071136
34antigen processing and presentation of endogenous antigen (GO:0019883)3.00763715
35positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.99988761
36response to muramyl dipeptide (GO:0032495)2.98545113
37detection of biotic stimulus (GO:0009595)2.98261818
38negative regulation of lymphocyte mediated immunity (GO:0002707)2.97870229
39cellular response to interleukin-15 (GO:0071350)2.96053946
40response to peptidoglycan (GO:0032494)2.94302340
41macrophage activation (GO:0042116)2.91533496
42leukocyte aggregation (GO:0070486)2.89063045
43germinal center formation (GO:0002467)2.88448511
44neutrophil mediated immunity (GO:0002446)2.86840512
45regulation of necroptotic process (GO:0060544)2.86259009
46regulation of interferon-beta biosynthetic process (GO:0045357)2.85624540
47response to host (GO:0075136)2.81853446
48response to host defenses (GO:0052200)2.81853446
49response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.81853446
50production of molecular mediator involved in inflammatory response (GO:0002532)2.81343820
51cellular response to epinephrine stimulus (GO:0071872)2.80326385
52response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.79744535
53response to host immune response (GO:0052572)2.79744535
54positive thymic T cell selection (GO:0045059)2.75576678
55regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.71045525
56regulation of interleukin-12 biosynthetic process (GO:0045075)2.67081761
57embryonic process involved in female pregnancy (GO:0060136)2.66735344
58T cell selection (GO:0045058)2.61845753
59detection of bacterium (GO:0016045)2.60605390
60myeloid leukocyte mediated immunity (GO:0002444)2.58576481
61regulation of B cell differentiation (GO:0045577)2.58392368
62negative regulation of T-helper cell differentiation (GO:0045623)2.57017453
63negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.57017453
64activated T cell proliferation (GO:0050798)2.56119001
65T cell migration (GO:0072678)2.55943934
66positive regulation of tolerance induction (GO:0002645)2.55506262
67regulation of tolerance induction (GO:0002643)2.53729987
68negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.49708089
69negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.49436927
70negative regulation of leukocyte mediated immunity (GO:0002704)2.47296938
71regulation of T cell tolerance induction (GO:0002664)2.43874288
72hypotonic response (GO:0006971)2.43612578
73tolerance induction (GO:0002507)2.38300380
74lipopolysaccharide-mediated signaling pathway (GO:0031663)2.37560072
75negative regulation of erythrocyte differentiation (GO:0045647)2.36811917
76JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.36686838
77negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.35879841
78phospholipid translocation (GO:0045332)2.35549082
79lipid translocation (GO:0034204)2.35549082
80myeloid cell activation involved in immune response (GO:0002275)2.34311389
81histone H3-K4 trimethylation (GO:0080182)2.34290706
82neutrophil activation involved in immune response (GO:0002283)2.34035272
83negative regulation of B cell proliferation (GO:0030889)2.33638345
84positive regulation of granulocyte differentiation (GO:0030854)2.33067395
85antigen processing and presentation via MHC class Ib (GO:0002475)2.32842690
86regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.31107710
87cytoplasmic mRNA processing body assembly (GO:0033962)2.30547621
88regulation of macrophage cytokine production (GO:0010935)2.29780284
89positive regulation of interferon-alpha production (GO:0032727)2.29772932
90negative regulation of adaptive immune response (GO:0002820)2.29536405
91thymic T cell selection (GO:0045061)2.28788396
92response to type I interferon (GO:0034340)2.27946202
93monoubiquitinated protein deubiquitination (GO:0035520)2.27526602
94type I interferon signaling pathway (GO:0060337)2.26945889
95cellular response to type I interferon (GO:0071357)2.26945889
96interleukin-6-mediated signaling pathway (GO:0070102)2.26268309
97cellular response to growth hormone stimulus (GO:0071378)2.25845903
98positive regulation of B cell differentiation (GO:0045579)2.25418260
99hepatocyte apoptotic process (GO:0097284)2.24946215
100T-helper cell differentiation (GO:0042093)2.24564134

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.62929299
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.92959616
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.48397077
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.39815893
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.80025563
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.71031601
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.68681355
8RUNX_20019798_ChIP-Seq_JUKART_Human2.63914015
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.43757957
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.32125490
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.31130526
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.29646200
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.23328765
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.15906014
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.08333952
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.08249895
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07424728
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.03526994
19VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.98698220
20BP1_19119308_ChIP-ChIP_Hs578T_Human1.95940789
21VDR_24787735_ChIP-Seq_THP-1_Human1.87984887
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87323876
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.87133918
24SCL_19346495_ChIP-Seq_HPC-7_Human1.79506721
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74346015
26MYB_26560356_Chip-Seq_TH2_Human1.66607789
27GATA1_22025678_ChIP-Seq_K562_Human1.65130615
28ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56899384
29SPI1_23127762_ChIP-Seq_K562_Human1.52463147
30GATA2_21666600_ChIP-Seq_HMVEC_Human1.47169065
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47163017
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43640000
33TP53_16413492_ChIP-PET_HCT116_Human1.41592304
34MYB_26560356_Chip-Seq_TH1_Human1.39153514
35ESR1_20079471_ChIP-ChIP_T-47D_Human1.37612875
36TCF7_22412390_ChIP-Seq_EML_Mouse1.36894106
37ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.35125049
38PU_27001747_Chip-Seq_BMDM_Mouse1.34047402
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32222318
40VDR_24763502_ChIP-Seq_THP-1_Human1.31906638
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28445299
42CTNNB1_20460455_ChIP-Seq_HCT116_Human1.28019005
43PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25865835
44NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.25394526
45GATA3_27048872_Chip-Seq_THYMUS_Human1.24466977
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23522286
47AHR_22903824_ChIP-Seq_MCF-7_Human1.22389914
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22163517
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21978176
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.21906308
51GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19767052
52MAF_26560356_Chip-Seq_TH1_Human1.17626090
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.16024302
54CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15928825
55RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.13347924
56SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07644936
57STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07297441
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.07156625
59TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06459641
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05525375
61DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04871505
62AR_21572438_ChIP-Seq_LNCaP_Human1.04194671
63BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03199652
64KDM2B_26808549_Chip-Seq_DND41_Human1.01732025
65SPI1_23547873_ChIP-Seq_NB4_Human1.00981455
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.00713058
67KDM2B_26808549_Chip-Seq_JURKAT_Human1.00158785
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00043989
69SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99974866
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99602995
71NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99602995
72E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99094614
73FOXA2_19822575_ChIP-Seq_HepG2_Human0.98965515
74RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98958878
75NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97242338
76RUNX1_22412390_ChIP-Seq_EML_Mouse0.96760013
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96642024
78GATA3_26560356_Chip-Seq_TH2_Human0.96275620
79SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95836524
80PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95362234
81EP300_21415370_ChIP-Seq_HL-1_Mouse0.95263583
82GATA1_19941827_ChIP-Seq_MEL86_Mouse0.94855352
83GATA2_19941826_ChIP-Seq_K562_Human0.93290916
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93030214
85CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91617625
86BRD4_25478319_ChIP-Seq_HGPS_Human0.90733697
87TP63_23658742_ChIP-Seq_EP156T_Human0.90666204
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89789703
89GATA1_19941826_ChIP-Seq_K562_Human0.89165156
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.88170305
91UTX_26944678_Chip-Seq_JUKART_Human0.87106822
92MYC_22102868_ChIP-Seq_BL_Human0.87051865
93GBX2_23144817_ChIP-Seq_PC3_Human0.86906652
94SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.86604439
95SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.86604439
96PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86314698
97PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84947611
98CJUN_26792858_Chip-Seq_BT549_Human0.84262654
99GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84044148
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82627649

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.13329607
2MP0003724_increased_susceptibility_to3.74837177
3MP0003303_peritoneal_inflammation3.21327345
4MP0003300_gastrointestinal_ulcer3.06350113
5MP0003436_decreased_susceptibility_to2.85997357
6MP0001835_abnormal_antigen_presentation2.84589345
7MP0003763_abnormal_thymus_physiology2.69972615
8MP0008057_abnormal_DNA_replication2.38859940
9MP0002009_preneoplasia2.31524306
10MP0003828_pulmonary_edema2.28454753
11MP0001800_abnormal_humoral_immune2.19713332
12MP0002419_abnormal_innate_immunity2.15576452
13MP0005000_abnormal_immune_tolerance1.95925667
14MP0000685_abnormal_immune_system1.94441572
15MP0003091_abnormal_cell_migration1.94225286
16MP0002166_altered_tumor_susceptibility1.89969227
17MP0005451_abnormal_body_composition1.88754342
18MP0004130_abnormal_muscle_cell1.84604063
19MP0008260_abnormal_autophagy1.83705834
20MP0001790_abnormal_immune_system1.82793262
21MP0005387_immune_system_phenotype1.82793262
22MP0002723_abnormal_immune_serum1.82446723
23MP0003172_abnormal_lysosome_physiology1.80386764
24MP0005025_abnormal_response_to1.76839487
25MP0002452_abnormal_antigen_presenting1.75720398
26MP0002420_abnormal_adaptive_immunity1.73936637
27MP0001819_abnormal_immune_cell1.71595204
28MP0005076_abnormal_cell_differentiation1.62835106
29MP0004947_skin_inflammation1.62272668
30MP0002396_abnormal_hematopoietic_system1.60075758
31MP0003045_fibrosis1.59224932
32MP0005671_abnormal_response_to1.59110705
33MP0001851_eye_inflammation1.59048834
34MP0001533_abnormal_skeleton_physiology1.57513874
35MP0009785_altered_susceptibility_to1.56428925
36MP0006082_CNS_inflammation1.56194477
37MP0003705_abnormal_hypodermis_morpholog1.51791820
38MP0010352_gastrointestinal_tract_polyps1.51771980
39MP0004808_abnormal_hematopoietic_stem1.51750997
40MP0002405_respiratory_system_inflammati1.51721336
41MP0004883_abnormal_blood_vessel1.51665796
42MP0002998_abnormal_bone_remodeling1.49971826
43MP0005409_darkened_coat_color1.45202130
44MP0004510_myositis1.43374982
45MP0004381_abnormal_hair_follicle1.42436090
46MP0002398_abnormal_bone_marrow1.41078237
47MP0003690_abnormal_glial_cell1.39543721
48MP0000716_abnormal_immune_system1.37002453
49MP0008004_abnormal_stomach_pH1.35972135
50MP0002332_abnormal_exercise_endurance1.35430367
51MP0001958_emphysema1.34229172
52MP0003183_abnormal_peptide_metabolism1.33945544
53MP0005164_abnormal_response_to1.32607514
54MP0000465_gastrointestinal_hemorrhage1.30943295
55MP0003191_abnormal_cellular_cholesterol1.30328970
56MP0009278_abnormal_bone_marrow1.30136559
57MP0002006_tumorigenesis1.29201192
58MP0000703_abnormal_thymus_morphology1.27551035
59MP0010155_abnormal_intestine_physiology1.26653097
60MP0005310_abnormal_salivary_gland1.24103351
61MP0006054_spinal_hemorrhage1.20721901
62MP0002148_abnormal_hypersensitivity_rea1.19732694
63MP0005464_abnormal_platelet_physiology1.18605185
64MP0003656_abnormal_erythrocyte_physiolo1.17328700
65MP0002722_abnormal_immune_system1.16590310
66MP0003566_abnormal_cell_adhesion1.13437073
67MP0001545_abnormal_hematopoietic_system1.13298891
68MP0005397_hematopoietic_system_phenotyp1.13298891
69MP0001845_abnormal_inflammatory_respons1.10886875
70MP0000689_abnormal_spleen_morphology1.10632911
71MP0000858_altered_metastatic_potential1.07075949
72MP0004484_altered_response_of1.06544798
73MP0000604_amyloidosis1.01886075
74MP0003279_aneurysm1.00899299
75MP0000015_abnormal_ear_pigmentation0.98836071
76MP0003448_altered_tumor_morphology0.98607076
77MP0002429_abnormal_blood_cell0.98036422
78MP0008438_abnormal_cutaneous_collagen0.95886689
79MP0003221_abnormal_cardiomyocyte_apopto0.95458966
80MP0004185_abnormal_adipocyte_glucose0.93786332
81MP0003866_abnormal_defecation0.93581570
82MP0004036_abnormal_muscle_relaxation0.91610065
83MP0002933_joint_inflammation0.90456268
84MP0001915_intracranial_hemorrhage0.88351076
85MP0002168_other_aberrant_phenotype0.88106707
86MP0000249_abnormal_blood_vessel0.85973387
87MP0004084_abnormal_cardiac_muscle0.85122932
88MP0005666_abnormal_adipose_tissue0.84580915
89MP0009115_abnormal_fat_cell0.84184211
90MP0005174_abnormal_tail_pigmentation0.83393746
91MP0000733_abnormal_muscle_development0.82659888
92MP0000767_abnormal_smooth_muscle0.81793434
93MP0009764_decreased_sensitivity_to0.80372083
94MP0000371_diluted_coat_color0.80075399
95MP0003453_abnormal_keratinocyte_physiol0.79991871
96MP0003646_muscle_fatigue0.78387451
97MP0008469_abnormal_protein_level0.77186552
98MP0002133_abnormal_respiratory_system0.76520126
99MP0005388_respiratory_system_phenotype0.76520126
100MP0005023_abnormal_wound_healing0.74078570

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.08474660
2Recurrent bacterial skin infections (HP:0005406)3.91448007
3T lymphocytopenia (HP:0005403)3.74310345
4Orchitis (HP:0100796)3.49777006
5Recurrent abscess formation (HP:0002722)3.48431477
6Myositis (HP:0100614)3.47101734
7Retrobulbar optic neuritis (HP:0100654)3.46204137
8Optic neuritis (HP:0100653)3.46204137
9Abnormality of T cell number (HP:0011839)3.38924545
10Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.18418905
11Gingivitis (HP:0000230)3.01692390
12Gastrointestinal infarctions (HP:0005244)2.95636896
13Subacute progressive viral hepatitis (HP:0006572)2.92342094
14Spontaneous hematomas (HP:0007420)2.90016827
15Recurrent gram-negative bacterial infections (HP:0005420)2.81303522
16Peritonitis (HP:0002586)2.77731206
17Recurrent fungal infections (HP:0002841)2.75402954
18Abnormality of the fingertips (HP:0001211)2.68186741
19Absent frontal sinuses (HP:0002688)2.59703877
20Keratoconjunctivitis sicca (HP:0001097)2.59215220
21Recurrent skin infections (HP:0001581)2.54225973
22Recurrent cutaneous fungal infections (HP:0011370)2.46209758
23Chronic mucocutaneous candidiasis (HP:0002728)2.46209758
24Abnormality of macrophages (HP:0004311)2.44482123
25Mediastinal lymphadenopathy (HP:0100721)2.43836865
26Stomatitis (HP:0010280)2.43581089
27Aortic aneurysm (HP:0004942)2.39123021
28Spinal cord lesions (HP:0100561)2.36386051
29Syringomyelia (HP:0003396)2.36386051
30Difficulty running (HP:0009046)2.32514207
31Keratoconjunctivitis (HP:0001096)2.32188792
32Spondylolisthesis (HP:0003302)2.31621250
33Colitis (HP:0002583)2.31361509
34Abnormal delayed hypersensitivity skin test (HP:0002963)2.27550330
35Arterial thrombosis (HP:0004420)2.27241656
36Chest pain (HP:0100749)2.25312167
37Slow saccadic eye movements (HP:0000514)2.22928078
38Recurrent viral infections (HP:0004429)2.22282049
39Gingival bleeding (HP:0000225)2.21616507
40Papillary thyroid carcinoma (HP:0002895)2.19915553
41Periodontitis (HP:0000704)2.19130850
42Viral hepatitis (HP:0006562)2.15085039
43Hematochezia (HP:0002573)2.14733585
44Arterial tortuosity (HP:0005116)2.14283097
45Hemoptysis (HP:0002105)2.13519249
46Vasculitis (HP:0002633)2.12601154
47Elevated erythrocyte sedimentation rate (HP:0003565)2.11758939
48Pulmonary infiltrates (HP:0002113)2.05033478
49Cellulitis (HP:0100658)2.03946182
50Osteolytic defects of the hand bones (HP:0009699)2.03848025
51Osteolytic defects of the phalanges of the hand (HP:0009771)2.03848025
52Autoimmune hemolytic anemia (HP:0001890)2.03383858
53Inflammation of the large intestine (HP:0002037)2.03142940
54Meningitis (HP:0001287)2.01201388
55Dislocated radial head (HP:0003083)2.01111594
56Thoracolumbar scoliosis (HP:0002944)2.01033103
57Narrow palate (HP:0000189)1.94994352
58Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.94569746
59Vascular tortuosity (HP:0004948)1.93366660
60Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.93247593
61Cerebral aneurysm (HP:0004944)1.88438115
62Gastrointestinal inflammation (HP:0004386)1.87373397
63Subaortic stenosis (HP:0001682)1.87220970
64Abnormality of the left ventricular outflow tract (HP:0011103)1.87220970
65Overgrowth (HP:0001548)1.86683209
66Leukocytosis (HP:0001974)1.84623388
67Abnormality of T cells (HP:0002843)1.83933230
68Vertebral arch anomaly (HP:0008438)1.83505982
69Genetic anticipation (HP:0003743)1.82020073
70Persistence of primary teeth (HP:0006335)1.81409667
71Mitral valve prolapse (HP:0001634)1.81077974
72Encephalitis (HP:0002383)1.80954696
73Abnormality of the peritoneum (HP:0002585)1.80059897
74Dilatation of the ascending aorta (HP:0005111)1.79734386
75Aneurysm (HP:0002617)1.79313955
76Abnormality of the radial head (HP:0003995)1.78284193
77Abnormality of the endocardium (HP:0004306)1.78115076
78Broad face (HP:0000283)1.77992625
79Pulmonary embolism (HP:0002204)1.76158731
80Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.74995412
81Dysmetric saccades (HP:0000641)1.73005427
82Abnormality of the vasculature of the conjunctiva (HP:0008054)1.71432970
83Osteomyelitis (HP:0002754)1.71431807
84Conjunctival telangiectasia (HP:0000524)1.68705400
85Neonatal hypoglycemia (HP:0001998)1.68040599
86Acute myeloid leukemia (HP:0004808)1.67516618
87Aortic dissection (HP:0002647)1.67409950
88Epistaxis (HP:0000421)1.67209600
89Coarse hair (HP:0002208)1.65992391
90Recurrent bronchitis (HP:0002837)1.64862089
91Asymmetric septal hypertrophy (HP:0001670)1.64798833
92Thickened calvaria (HP:0002684)1.64688219
93Truncal obesity (HP:0001956)1.60785382
94Relative macrocephaly (HP:0004482)1.60425902
95Large earlobe (HP:0009748)1.59728007
96Interstitial pulmonary disease (HP:0006530)1.59641812
97Hyporeflexia of lower limbs (HP:0002600)1.57650849
98Pustule (HP:0200039)1.56120111
99Amyloidosis (HP:0011034)1.55638935
100Prolonged bleeding time (HP:0003010)1.55173002

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B2.70559684
2BLK2.39601522
3MAP2K32.25343612
4JAK12.21689221
5RIPK42.20447551
6CDK122.07139761
7TYK22.06738251
8MAP4K11.87691948
9AKT31.83410552
10CSK1.78752975
11MAP3K141.77131197
12TTN1.72812278
13FGFR31.71719766
14ZAP701.70661125
15BRD41.57286291
16JAK31.51047330
17MAP3K61.46324889
18IKBKE1.46283119
19PIK3CG1.45127043
20RIPK11.44649722
21SGK21.44230489
22BTK1.42791930
23TRIB31.41958697
24MAP3K21.41949079
25FES1.40142368
26IRAK41.39684306
27TXK1.37049931
28SGK31.35523512
29WNK11.34414830
30FGFR41.30690557
31HCK1.28006003
32YES11.27688700
33JAK21.25604948
34PDGFRB1.25005874
35NEK91.23445916
36NLK1.23107285
37FRK1.21345849
38CAMK1D1.19098458
39TAOK31.18840095
40SYK1.17353013
41CAMKK21.17133190
42CAMK1G1.16586086
43FGR1.16461993
44TEC1.15356036
45EPHB11.14897387
46KSR21.13945680
47ITK1.12591950
48TGFBR21.12435321
49MELK1.12191387
50TRPM71.11976684
51MAP3K131.10738433
52MARK21.10189996
53RET1.06250703
54GRK61.05395601
55MAP3K71.04990004
56BMPR21.02494254
57PDGFRA1.01242786
58EPHA31.00421757
59IRAK11.00416200
60CDK61.00374176
61LATS10.96006023
62MAP3K100.95862671
63STK380.94931917
64LCK0.93944439
65CDC42BPA0.89831820
66PDK10.87696872
67MAP3K30.84639256
68MAP3K10.83631643
69OBSCN0.82612189
70MAPK70.80841068
71SGK2230.77188066
72SGK4940.77188066
73PKN20.75198237
74LYN0.74895297
75IRAK20.73863449
76CAMK40.73320172
77CSF1R0.71822998
78MAP3K50.71413512
79PDPK10.70857124
80KSR10.70019089
81MAPK120.67819680
82ERN10.67343761
83HIPK20.66718740
84KIT0.66407953
85ICK0.64638772
86STK110.64288417
87PRKAA20.64157696
88MAP2K40.62666728
89TBK10.59795455
90PTK2B0.59285438
91ACVR1B0.58537735
92NEK60.57946521
93PIM10.57663794
94TAOK10.56479450
95MTOR0.56473475
96EEF2K0.56050342
97SGK10.55711827
98CAMKK10.55063678
99CHUK0.51527153
100MARK30.47353041

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.05591981
2Leishmaniasis_Homo sapiens_hsa051401.87463953
3B cell receptor signaling pathway_Homo sapiens_hsa046621.87072527
4T cell receptor signaling pathway_Homo sapiens_hsa046601.63525414
5Non-small cell lung cancer_Homo sapiens_hsa052231.60736634
6Toll-like receptor signaling pathway_Homo sapiens_hsa046201.57766504
7Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.57163926
8Acute myeloid leukemia_Homo sapiens_hsa052211.56822438
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.50583004
10Chronic myeloid leukemia_Homo sapiens_hsa052201.48551346
11NOD-like receptor signaling pathway_Homo sapiens_hsa046211.48150577
12Dorso-ventral axis formation_Homo sapiens_hsa043201.48073506
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.46507158
14TNF signaling pathway_Homo sapiens_hsa046681.42823963
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.42711137
16Measles_Homo sapiens_hsa051621.41663284
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.39035243
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.38448847
19Prolactin signaling pathway_Homo sapiens_hsa049171.36955766
20Pancreatic cancer_Homo sapiens_hsa052121.35414350
21Toxoplasmosis_Homo sapiens_hsa051451.35160043
22Malaria_Homo sapiens_hsa051441.32238421
23Tuberculosis_Homo sapiens_hsa051521.30132038
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.29563422
25Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28999448
26Staphylococcus aureus infection_Homo sapiens_hsa051501.27598472
27Platelet activation_Homo sapiens_hsa046111.26310191
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25262547
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.24616706
30Renal cell carcinoma_Homo sapiens_hsa052111.23133719
31Endometrial cancer_Homo sapiens_hsa052131.22710036
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.20023767
33FoxO signaling pathway_Homo sapiens_hsa040681.18394436
34VEGF signaling pathway_Homo sapiens_hsa043701.18316933
35Hepatitis B_Homo sapiens_hsa051611.16779816
36Influenza A_Homo sapiens_hsa051641.16161913
37ErbB signaling pathway_Homo sapiens_hsa040121.13247614
38Chemokine signaling pathway_Homo sapiens_hsa040621.12725002
39Inositol phosphate metabolism_Homo sapiens_hsa005621.11970396
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.11193158
41mTOR signaling pathway_Homo sapiens_hsa041501.10351542
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.07191604
43Hepatitis C_Homo sapiens_hsa051601.03590019
44Amoebiasis_Homo sapiens_hsa051461.01505278
45Glioma_Homo sapiens_hsa052141.01104829
46Choline metabolism in cancer_Homo sapiens_hsa052310.99872808
47Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98226705
48Insulin resistance_Homo sapiens_hsa049310.97801520
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97788524
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.97668653
51GnRH signaling pathway_Homo sapiens_hsa049120.96384077
52Prostate cancer_Homo sapiens_hsa052150.96376190
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.93497433
54Graft-versus-host disease_Homo sapiens_hsa053320.93305881
55Small cell lung cancer_Homo sapiens_hsa052220.91644504
56Focal adhesion_Homo sapiens_hsa045100.90508152
57Type II diabetes mellitus_Homo sapiens_hsa049300.89248267
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89071048
59Hematopoietic cell lineage_Homo sapiens_hsa046400.88802792
60Colorectal cancer_Homo sapiens_hsa052100.88578010
61Proteoglycans in cancer_Homo sapiens_hsa052050.87455974
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.84147863
63Legionellosis_Homo sapiens_hsa051340.83730443
64Allograft rejection_Homo sapiens_hsa053300.82399079
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82344267
66Primary immunodeficiency_Homo sapiens_hsa053400.82275380
67Viral myocarditis_Homo sapiens_hsa054160.81381204
68African trypanosomiasis_Homo sapiens_hsa051430.80843078
69Long-term potentiation_Homo sapiens_hsa047200.80376168
70MicroRNAs in cancer_Homo sapiens_hsa052060.79654480
71Apoptosis_Homo sapiens_hsa042100.78933348
72Autoimmune thyroid disease_Homo sapiens_hsa053200.76954372
73Estrogen signaling pathway_Homo sapiens_hsa049150.76605019
74Other glycan degradation_Homo sapiens_hsa005110.75584101
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75221500
76Notch signaling pathway_Homo sapiens_hsa043300.74206931
77Insulin signaling pathway_Homo sapiens_hsa049100.73106720
78Herpes simplex infection_Homo sapiens_hsa051680.72716301
79Adherens junction_Homo sapiens_hsa045200.72369942
80MAPK signaling pathway_Homo sapiens_hsa040100.71780417
81Pertussis_Homo sapiens_hsa051330.71483378
82Viral carcinogenesis_Homo sapiens_hsa052030.66376615
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66287793
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66202458
85Thyroid cancer_Homo sapiens_hsa052160.66200183
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64361219
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64234346
88HIF-1 signaling pathway_Homo sapiens_hsa040660.62234309
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57084798
90Renin secretion_Homo sapiens_hsa049240.57084441
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56660635
92Fatty acid biosynthesis_Homo sapiens_hsa000610.55431659
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55273093
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54418355
95Oxytocin signaling pathway_Homo sapiens_hsa049210.53049221
96Rap1 signaling pathway_Homo sapiens_hsa040150.52875990
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.52607650
98Salmonella infection_Homo sapiens_hsa051320.52589423
99Pathways in cancer_Homo sapiens_hsa052000.51660421
100HTLV-I infection_Homo sapiens_hsa051660.50608883

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