PCNX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene contains coding mononucleotide repeats that are associated with tumors of high mcrosatellite instability (MSI-H). Defects in this gene are involved in the tumorigenesis of MSI-H colorectal carcinomas. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sulfation (GO:0051923)7.02938921
2behavioral response to nicotine (GO:0035095)6.93616671
3cellular response to ATP (GO:0071318)6.81846279
4regulation of short-term neuronal synaptic plasticity (GO:0048172)6.32718140
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.05680882
6synaptic vesicle maturation (GO:0016188)6.05076467
7regulation of glomerulus development (GO:0090192)6.03903151
8locomotory exploration behavior (GO:0035641)5.93227247
9cell proliferation in forebrain (GO:0021846)5.91046096
10positive regulation of fatty acid beta-oxidation (GO:0032000)5.76388186
11vocalization behavior (GO:0071625)5.66598756
12regulation of cell proliferation involved in kidney development (GO:1901722)5.63682804
13synaptic vesicle exocytosis (GO:0016079)5.50267327
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.50083132
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.47020088
16glutamate secretion (GO:0014047)5.41022233
17synaptic vesicle docking involved in exocytosis (GO:0016081)5.40978855
18neuronal action potential propagation (GO:0019227)5.15104356
19ionotropic glutamate receptor signaling pathway (GO:0035235)5.12429586
20regulation of glutamate receptor signaling pathway (GO:1900449)5.07423716
21regulation of synaptic vesicle exocytosis (GO:2000300)5.05359698
22regulation of phospholipid biosynthetic process (GO:0071071)5.02429328
23positive regulation of fatty acid oxidation (GO:0046321)5.00472028
24protein localization to synapse (GO:0035418)4.87265941
25opsonization (GO:0008228)4.86397269
26regulation of posttranscriptional gene silencing (GO:0060147)4.78892277
27regulation of gene silencing by miRNA (GO:0060964)4.78892277
28regulation of gene silencing by RNA (GO:0060966)4.78892277
29negative regulation of hormone biosynthetic process (GO:0032353)4.69979823
30cellular anion homeostasis (GO:0030002)4.64808497
31positive regulation of metanephros development (GO:0072216)4.64468727
32regulation of neuronal synaptic plasticity (GO:0048168)4.63364912
33regulation of long-term neuronal synaptic plasticity (GO:0048169)4.62590998
34synaptic transmission, glutamatergic (GO:0035249)4.57363355
35regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.56872217
363-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.55550470
37purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.55550470
38tooth mineralization (GO:0034505)4.55078946
39regulation of synaptic vesicle transport (GO:1902803)4.54588336
40serotonin metabolic process (GO:0042428)4.52384971
41glutamate receptor signaling pathway (GO:0007215)4.50433524
42exploration behavior (GO:0035640)4.49762223
43neurotransmitter secretion (GO:0007269)4.48709339
44neuron cell-cell adhesion (GO:0007158)4.41315949
45negative regulation of systemic arterial blood pressure (GO:0003085)4.33946038
46pharyngeal system development (GO:0060037)4.28044504
47neuron-neuron synaptic transmission (GO:0007270)4.26050752
48neurotransmitter-gated ion channel clustering (GO:0072578)4.25322577
49regulation of synapse structural plasticity (GO:0051823)4.25207394
50regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.24190586
51negative regulation of appetite (GO:0032099)4.23973830
52negative regulation of response to food (GO:0032096)4.23973830
53long-term memory (GO:0007616)4.20420030
54membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.13034533
55response to UV-C (GO:0010225)4.13004271
56regulation of excitatory postsynaptic membrane potential (GO:0060079)4.12774477
57multicellular organismal movement (GO:0050879)4.12068262
58musculoskeletal movement (GO:0050881)4.12068262
59dendritic spine morphogenesis (GO:0060997)4.10402619
60positive regulation of membrane potential (GO:0045838)4.07911874
61flavonoid metabolic process (GO:0009812)4.07012571
62negative regulation of hormone metabolic process (GO:0032351)4.05915726
63layer formation in cerebral cortex (GO:0021819)4.00896001
64cellular potassium ion homeostasis (GO:0030007)3.97849798
65water-soluble vitamin biosynthetic process (GO:0042364)3.97064884
66gamma-aminobutyric acid transport (GO:0015812)3.94708778
67regulation of postsynaptic membrane potential (GO:0060078)3.90802701
68negative regulation of transcription regulatory region DNA binding (GO:2000678)3.87974941
69primary amino compound metabolic process (GO:1901160)3.87673311
70regulation of dendritic spine morphogenesis (GO:0061001)3.85701593
71positive regulation of cAMP-mediated signaling (GO:0043950)3.85554389
72regulation of sequestering of triglyceride (GO:0010889)3.85114032
73regulation of synaptic plasticity (GO:0048167)3.78665731
74plasma membrane repair (GO:0001778)3.78561074
75epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.75653699
76proline transport (GO:0015824)3.73462192
77kynurenine metabolic process (GO:0070189)3.68434196
78otic vesicle formation (GO:0030916)3.65216586
79cerebellar Purkinje cell differentiation (GO:0021702)3.62096479
80sodium ion export (GO:0071436)3.60858640
81activation of protein kinase A activity (GO:0034199)3.60624952
82neurotransmitter transport (GO:0006836)3.60236288
83regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.60091562
84neuromuscular process controlling balance (GO:0050885)3.60001504
85positive regulation of synapse maturation (GO:0090129)3.56881668
86long-term synaptic potentiation (GO:0060291)3.53722227
87transmission of nerve impulse (GO:0019226)3.53120944
88regulation of neurotransmitter secretion (GO:0046928)3.52829470
89positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.50979863
90synaptic vesicle endocytosis (GO:0048488)3.50907999
91positive regulation of cardiac muscle cell differentiation (GO:2000727)3.49726104
92regulation of DNA endoreduplication (GO:0032875)3.49645744
93positive regulation of neurotransmitter secretion (GO:0001956)3.49621056
94regulation of synaptic transmission, glutamatergic (GO:0051966)3.49376737
95gamma-aminobutyric acid signaling pathway (GO:0007214)3.48963800
96neuromuscular process controlling posture (GO:0050884)3.48019975
97neuronal ion channel clustering (GO:0045161)3.47827446
98positive regulation of neurotransmitter transport (GO:0051590)3.46367782
99regulation of fatty acid beta-oxidation (GO:0031998)3.46263850
100positive regulation of synaptic transmission, GABAergic (GO:0032230)3.46032686
101indole-containing compound metabolic process (GO:0042430)3.42966600
102tryptophan catabolic process (GO:0006569)3.42845672
103indole-containing compound catabolic process (GO:0042436)3.42845672
104indolalkylamine catabolic process (GO:0046218)3.42845672
105auditory behavior (GO:0031223)3.42368859
106membrane depolarization during action potential (GO:0086010)3.41933045
107neuron recognition (GO:0008038)3.41518863
108membrane depolarization (GO:0051899)3.40699675
109G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.37959274
110positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.36540154
111regulation of collateral sprouting (GO:0048670)3.36524690
112regulation of neurotransmitter levels (GO:0001505)3.35504972
113G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.35371147
114cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.35185987
115regulation of hippo signaling (GO:0035330)3.34182493
116negative chemotaxis (GO:0050919)3.32721418
117regulation of DNA damage checkpoint (GO:2000001)3.30445253
118regulation of metanephros development (GO:0072215)3.30246164
119prepulse inhibition (GO:0060134)3.28691666
120negative regulation of synaptic transmission, GABAergic (GO:0032229)3.28440015
121negative regulation of gene silencing (GO:0060969)3.28421679
122regulation of neurotransmitter transport (GO:0051588)3.28081383
123regulation of dendritic spine development (GO:0060998)3.26514901
124response to auditory stimulus (GO:0010996)3.25939600
125regulation of vesicle fusion (GO:0031338)3.25241229
126glycine transport (GO:0015816)3.25195845
127reflex (GO:0060004)3.24056072
128postsynaptic membrane organization (GO:0001941)3.23703950
129negative regulation of platelet activation (GO:0010544)3.23339636
130dorsal/ventral axis specification (GO:0009950)3.22622010
131positive regulation of dendritic spine development (GO:0060999)3.21940705
132membrane hyperpolarization (GO:0060081)3.21861705
133somite development (GO:0061053)3.21313961
134dendritic spine organization (GO:0097061)3.19974708
135negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.17647075
136regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.17397454
137lateral sprouting from an epithelium (GO:0060601)3.16499415
138learning (GO:0007612)3.16488015
139behavioral fear response (GO:0001662)3.16214642
140behavioral defense response (GO:0002209)3.16214642
141cell communication by electrical coupling (GO:0010644)3.14734096
142positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.14718251
143axonal fasciculation (GO:0007413)3.14456391
144cell differentiation in hindbrain (GO:0021533)3.13941123
145peristalsis (GO:0030432)3.12511686
146neuronal action potential (GO:0019228)3.12354008
147chemosensory behavior (GO:0007635)3.12123167
148positive regulation of synaptic transmission (GO:0050806)3.10441593
149protein polyglutamylation (GO:0018095)3.08849532
150spinal cord motor neuron differentiation (GO:0021522)3.08445527
151innervation (GO:0060384)3.07851742
152negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.07757956
153response to histamine (GO:0034776)3.07689649
154regulation of synaptic transmission (GO:0050804)3.07562681
155positive regulation of dendritic spine morphogenesis (GO:0061003)3.07220589
156regulation of voltage-gated calcium channel activity (GO:1901385)3.06927936
157synaptic transmission (GO:0007268)3.06876166
158neuromuscular process (GO:0050905)3.05696967
159dentate gyrus development (GO:0021542)3.05616532
160behavioral response to cocaine (GO:0048148)3.05091581
161lung morphogenesis (GO:0060425)3.04639882
162L-amino acid import (GO:0043092)3.03888793
163regulation of female receptivity (GO:0045924)3.00589615
164intraspecies interaction between organisms (GO:0051703)3.00448811
165social behavior (GO:0035176)3.00448811
166regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.99840559
167behavioral response to pain (GO:0048266)2.97049718
168negative regulation of axon extension involved in axon guidance (GO:0048843)2.95852804
169negative regulation of cardiac muscle tissue development (GO:0055026)2.94328371
170indolalkylamine metabolic process (GO:0006586)2.92905820
171presynaptic membrane assembly (GO:0097105)2.91360618
172embryonic hindlimb morphogenesis (GO:0035116)2.89149188
173neuromuscular synaptic transmission (GO:0007274)2.86853661
174regulation of response to food (GO:0032095)2.86112544
175angiogenesis involved in wound healing (GO:0060055)2.85991211
176renal system development (GO:0072001)2.82841343
177negative regulation by host of viral transcription (GO:0043922)2.80521688
178positive regulation of protein autophosphorylation (GO:0031954)2.79320496
179pituitary gland development (GO:0021983)2.79264477
180regulation of neurotransmitter uptake (GO:0051580)2.78737697
181startle response (GO:0001964)2.74196656
182positive regulation of gluconeogenesis (GO:0045722)2.74125820
183negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.73233609
184tryptophan metabolic process (GO:0006568)2.73142684
185N-acetylglucosamine metabolic process (GO:0006044)2.71919205
186positive regulation of glomerulus development (GO:0090193)2.71760463
187prostate gland growth (GO:0060736)2.69645211
188limb bud formation (GO:0060174)2.68744566
189regulation of calcium ion-dependent exocytosis (GO:0017158)2.68222940
190aorta morphogenesis (GO:0035909)2.65765971
191regulation of transcription regulatory region DNA binding (GO:2000677)2.64092938

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.23174946
2GBX2_23144817_ChIP-Seq_PC3_Human3.52718719
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.47387647
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.19219319
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.17186375
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12439786
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.86039755
8REST_21632747_ChIP-Seq_MESCs_Mouse2.84455808
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.82373412
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.82373412
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.74044113
12DROSHA_22980978_ChIP-Seq_HELA_Human2.72759749
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.65727202
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.58785150
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.58205122
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51819576
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49722298
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.49339475
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.33304567
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.32609303
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.30278266
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.28081679
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.27914168
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.24803845
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.15938299
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13912779
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.03506518
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.02689412
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01662114
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95983790
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.94997327
32FUS_26573619_Chip-Seq_HEK293_Human1.94611702
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.93080062
34AR_21572438_ChIP-Seq_LNCaP_Human1.73615699
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.70243467
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66751684
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65832191
38EWS_26573619_Chip-Seq_HEK293_Human1.64869612
39TAF15_26573619_Chip-Seq_HEK293_Human1.61915694
40SMAD4_21799915_ChIP-Seq_A2780_Human1.59678582
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59449689
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57131833
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49284071
44RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.38225567
45TDRD3_21172665_ChIP-Seq_MCF-7_Human1.35133669
46KDM2B_26808549_Chip-Seq_REH_Human1.34082196
47RING1B_27294783_Chip-Seq_ESCs_Mouse1.32415897
48IRF1_19129219_ChIP-ChIP_H3396_Human1.30675903
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30317573
50AUTS2_25519132_ChIP-Seq_293T-REX_Human1.28534538
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27786355
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27713015
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27226538
54VDR_22108803_ChIP-Seq_LS180_Human1.26605280
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.26190681
56ZNF274_21170338_ChIP-Seq_K562_Hela1.25675715
57P300_19829295_ChIP-Seq_ESCs_Human1.23993150
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23172301
59AR_19668381_ChIP-Seq_PC3_Human1.22673043
60TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.22488904
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22153112
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22062551
63CBP_20019798_ChIP-Seq_JUKART_Human1.22062551
64TP53_20018659_ChIP-ChIP_R1E_Mouse1.21832007
65SMAD4_21741376_ChIP-Seq_EPCs_Human1.20766375
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.19006063
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18664262
68AR_25329375_ChIP-Seq_VCAP_Human1.18595200
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18359162
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18140789
71STAT3_23295773_ChIP-Seq_U87_Human1.17800303
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.17047095
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16848470
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16396228
75ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16296067
76ER_23166858_ChIP-Seq_MCF-7_Human1.12937250
77HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12897875
78STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.12336499
79KDM2B_26808549_Chip-Seq_K562_Human1.11521065
80EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10289654
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.09909455
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.08689607
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08611342
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08411015
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07099580
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06787104
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06298873
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04991865
89P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04644581
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04057717
91TCF4_23295773_ChIP-Seq_U87_Human1.03877674
92BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03869469
93ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02976699
94MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02788370
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02652677
96BCAT_22108803_ChIP-Seq_LS180_Human1.02560728
97RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02177701
98WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01134666
99GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00991909
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.00473012
101PIAS1_25552417_ChIP-Seq_VCAP_Human1.00026951
102FLI1_21867929_ChIP-Seq_TH2_Mouse0.99787656
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99598798
104ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98650477
105TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98486941
106TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97944393
107LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97265689
108AHR_22903824_ChIP-Seq_MCF-7_Human0.97208076
109YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97010129
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96053647
111SMAD3_21741376_ChIP-Seq_HESCs_Human0.94647386
112TP53_16413492_ChIP-PET_HCT116_Human0.93689444
113SMAD3_21741376_ChIP-Seq_ESCs_Human0.93517792
114RNF2_27304074_Chip-Seq_NSC_Mouse0.93008705
115PRDM14_20953172_ChIP-Seq_ESCs_Human0.92727145
116CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90130945
117RUNX2_22187159_ChIP-Seq_PCA_Human0.89960473
118NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89685590
119SMAD4_21741376_ChIP-Seq_HESCs_Human0.89582708
120CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89339778
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88527019
122CTCF_27219007_Chip-Seq_Bcells_Human0.87223899
123TET1_21490601_ChIP-Seq_MESCs_Mouse0.85543160
124UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85327088
125RXR_22108803_ChIP-Seq_LS180_Human0.84906555
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83986619
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83986619
128VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.82798022
129TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82139108
130IGF1R_20145208_ChIP-Seq_DFB_Human0.81247522

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.01433367
2MP0003880_abnormal_central_pattern5.01718073
3MP0003635_abnormal_synaptic_transmissio4.32778567
4MP0004270_analgesia3.97068586
5MP0009745_abnormal_behavioral_response3.57132920
6MP0004134_abnormal_chest_morphology3.50965321
7MP0002063_abnormal_learning/memory/cond3.46626214
8MP0002064_seizures3.28188454
9MP0009046_muscle_twitch3.27871741
10MP0001968_abnormal_touch/_nociception3.20861688
11MP0002822_catalepsy3.14703767
12MP0002572_abnormal_emotion/affect_behav2.93598014
13MP0002272_abnormal_nervous_system2.78109332
14MP0006292_abnormal_olfactory_placode2.77042223
15MP0002734_abnormal_mechanical_nocicepti2.73718550
16MP0001486_abnormal_startle_reflex2.73493235
17MP0005423_abnormal_somatic_nervous2.62855726
18MP0000049_abnormal_middle_ear2.61700561
19MP0004130_abnormal_muscle_cell2.52475391
20MP0002736_abnormal_nociception_after2.46533380
21MP0001501_abnormal_sleep_pattern2.44805268
22MP0002735_abnormal_chemical_nociception2.34969386
23MP0002160_abnormal_reproductive_system2.29247041
24MP0009250_abnormal_appendicular_skeleto2.25069208
25MP0003195_calcinosis2.23607063
26MP0003646_muscle_fatigue2.17991076
27MP0001440_abnormal_grooming_behavior2.17588629
28MP0002733_abnormal_thermal_nociception2.06640461
29MP0002067_abnormal_sensory_capabilities2.02730690
30MP0001970_abnormal_pain_threshold2.02065646
31MP0008569_lethality_at_weaning1.99792319
32MP0000678_abnormal_parathyroid_gland1.99520216
33MP0002089_abnormal_postnatal_growth/wei1.90649317
34MP0004133_heterotaxia1.90498391
35MP0003329_amyloid_beta_deposits1.89618378
36MP0003879_abnormal_hair_cell1.88478158
37MP0004858_abnormal_nervous_system1.82227422
38MP0002184_abnormal_innervation1.77420875
39MP0004811_abnormal_neuron_physiology1.75976534
40MP0002249_abnormal_larynx_morphology1.75512150
41MP0009780_abnormal_chondrocyte_physiolo1.74189257
42MP0002557_abnormal_social/conspecific_i1.73380154
43MP0002876_abnormal_thyroid_physiology1.70139058
44MP0005386_behavior/neurological_phenoty1.68278582
45MP0004924_abnormal_behavior1.68278582
46MP0003938_abnormal_ear_development1.66590892
47MP0002909_abnormal_adrenal_gland1.66169117
48MP0000537_abnormal_urethra_morphology1.61257735
49MP0002138_abnormal_hepatobiliary_system1.60392181
50MP0003638_abnormal_response/metabolism_1.59007539
51MP0000778_abnormal_nervous_system1.56908851
52MP0005646_abnormal_pituitary_gland1.55740313
53MP0003119_abnormal_digestive_system1.55214197
54MP0001984_abnormal_olfaction1.54341412
55MP0000955_abnormal_spinal_cord1.52518230
56MP0009053_abnormal_anal_canal1.47415037
57MP0005389_reproductive_system_phenotype1.46871867
58MP0006276_abnormal_autonomic_nervous1.45061152
59MP0002066_abnormal_motor_capabilities/c1.44027279
60MP0003633_abnormal_nervous_system1.40538125
61MP0002882_abnormal_neuron_morphology1.38967004
62MP0003937_abnormal_limbs/digits/tail_de1.37376734
63MP0005670_abnormal_white_adipose1.36573074
64MP0004885_abnormal_endolymph1.33276631
65MP0003787_abnormal_imprinting1.33056019
66MP0001529_abnormal_vocalization1.30937823
67MP0003890_abnormal_embryonic-extraembry1.29627656
68MP0009384_cardiac_valve_regurgitation1.28616616
69MP0008877_abnormal_DNA_methylation1.28595710
70MP0003942_abnormal_urinary_system1.26713539
71MP0004142_abnormal_muscle_tone1.24261119
72MP0000026_abnormal_inner_ear1.22953457
73MP0005645_abnormal_hypothalamus_physiol1.21156422
74MP0001502_abnormal_circadian_rhythm1.19662404
75MP0003631_nervous_system_phenotype1.18504963
76MP0000013_abnormal_adipose_tissue1.18474761
77MP0009379_abnormal_foot_pigmentation1.13567824
78MP0001905_abnormal_dopamine_level1.13545420
79MP0002282_abnormal_trachea_morphology1.12345565
80MP0008872_abnormal_physiological_respon1.11569793
81MP0000613_abnormal_salivary_gland1.11170324
82MP0004145_abnormal_muscle_electrophysio1.09320818
83MP0000733_abnormal_muscle_development1.06896050
84MP0002928_abnormal_bile_duct1.05865119
85MP0002152_abnormal_brain_morphology1.05317369
86MP0002102_abnormal_ear_morphology1.04031514
87MP0002277_abnormal_respiratory_mucosa1.03978503
88MP0000534_abnormal_ureter_morphology1.03759085
89MP0000751_myopathy1.03509523
90MP0002653_abnormal_ependyma_morphology1.03215341
91MP0008874_decreased_physiological_sensi1.00976054
92MP0000569_abnormal_digit_pigmentation0.99613941
93MP0002229_neurodegeneration0.98973863
94MP0002116_abnormal_craniofacial_bone0.97254823
95MP0002163_abnormal_gland_morphology0.97183244
96MP0003075_altered_response_to0.96492106
97MP0000681_abnormal_thyroid_gland0.94667020
98MP0004742_abnormal_vestibular_system0.94233272
99MP0003283_abnormal_digestive_organ0.94205778
100MP0002069_abnormal_eating/drinking_beha0.93720510
101MP0001986_abnormal_taste_sensitivity0.92230123
102MP0008961_abnormal_basal_metabolism0.91160875
103MP0005448_abnormal_energy_balance0.90210318
104MP0001485_abnormal_pinna_reflex0.89371138
105MP0003122_maternal_imprinting0.88882718
106MP0001177_atelectasis0.88247968
107MP0001188_hyperpigmentation0.87915024
108MP0005551_abnormal_eye_electrophysiolog0.87275355
109MP0002751_abnormal_autonomic_nervous0.86521292
110MP0010386_abnormal_urinary_bladder0.85174367
111MP0005535_abnormal_body_temperature0.84702880
112MP0000604_amyloidosis0.84631997
113MP0003011_delayed_dark_adaptation0.83195567
114MP0003632_abnormal_nervous_system0.82736577
115MP0003936_abnormal_reproductive_system0.82080517
116MP0000920_abnormal_myelination0.81955770
117MP0001963_abnormal_hearing_physiology0.81569175
118MP0004085_abnormal_heartbeat0.80127978
119MP0003690_abnormal_glial_cell0.79536938
120MP0005174_abnormal_tail_pigmentation0.78898214
121MP0001853_heart_inflammation0.77418147
122MP0002932_abnormal_joint_morphology0.77340612
123MP0004510_myositis0.73674444
124MP0003634_abnormal_glial_cell0.73431977
125MP0005167_abnormal_blood-brain_barrier0.72754099
126MP0005394_taste/olfaction_phenotype0.70967636
127MP0005499_abnormal_olfactory_system0.70967636
128MP0000428_abnormal_craniofacial_morphol0.70842339
129MP0002837_dystrophic_cardiac_calcinosis0.70280610
130MP0005195_abnormal_posterior_eye0.69873033
131MP0002752_abnormal_somatic_nervous0.69546695
132MP0004215_abnormal_myocardial_fiber0.68720010
133MP0006072_abnormal_retinal_apoptosis0.68479534
134MP0001664_abnormal_digestion0.63928495
135MP0005409_darkened_coat_color0.63780306
136MP0003137_abnormal_impulse_conducting0.63226058
137MP0004484_altered_response_of0.61934476
138MP0000631_abnormal_neuroendocrine_gland0.58762719
139MP0002090_abnormal_vision0.57371549
140MP0002638_abnormal_pupillary_reflex0.54043251
141MP0010769_abnormal_survival0.52044396
142MP0001943_abnormal_respiration0.51455692
143MP0005623_abnormal_meninges_morphology0.50934393
144MP0003956_abnormal_body_size0.49816770
145MP0004233_abnormal_muscle_weight0.49269487
146MP0010770_preweaning_lethality0.49229825
147MP0002082_postnatal_lethality0.49229825
148MP0010768_mortality/aging0.48941586
149MP0004043_abnormal_pH_regulation0.48632163
150MP0003861_abnormal_nervous_system0.46120519

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.26502739
2Myokymia (HP:0002411)7.96118369
3Focal seizures (HP:0007359)6.16290029
4Visual hallucinations (HP:0002367)5.44532173
5Atonic seizures (HP:0010819)5.00777325
6Epileptic encephalopathy (HP:0200134)4.96916440
7Febrile seizures (HP:0002373)4.90627315
8Progressive cerebellar ataxia (HP:0002073)4.67516206
9Pendular nystagmus (HP:0012043)4.51884006
10Action tremor (HP:0002345)4.44354661
11Absence seizures (HP:0002121)4.30560722
12Generalized tonic-clonic seizures (HP:0002069)4.02890095
13Confusion (HP:0001289)4.00230337
14Dialeptic seizures (HP:0011146)3.93460121
15Gaze-evoked nystagmus (HP:0000640)3.82437527
16Poor eye contact (HP:0000817)3.80761844
17Porencephaly (HP:0002132)3.79720205
18Broad-based gait (HP:0002136)3.72472116
19Impaired vibration sensation in the lower limbs (HP:0002166)3.64465880
20Morphological abnormality of the middle ear (HP:0008609)3.58045590
21Supranuclear gaze palsy (HP:0000605)3.54574136
22Dysdiadochokinesis (HP:0002075)3.45040678
23Short 1st metacarpal (HP:0010034)3.44583760
24Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.44583760
25Ankle clonus (HP:0011448)3.43140843
26Dysmetria (HP:0001310)3.39391305
27Impaired social interactions (HP:0000735)3.37510044
28Abnormal social behavior (HP:0012433)3.37510044
29Depression (HP:0000716)3.35701136
30Abnormality of the nasal septum (HP:0000419)3.33733509
31Pancreatic cysts (HP:0001737)3.26945859
32Pancreatic fibrosis (HP:0100732)3.24150898
33Urinary bladder sphincter dysfunction (HP:0002839)3.20920578
34Abolished electroretinogram (ERG) (HP:0000550)3.18903442
35Anxiety (HP:0000739)3.15482855
36Hyperventilation (HP:0002883)3.15283075
37Absent rod-and cone-mediated responses on ERG (HP:0007688)3.12408023
38Truncal ataxia (HP:0002078)3.08411816
39True hermaphroditism (HP:0010459)3.03752364
40Impaired smooth pursuit (HP:0007772)3.03057202
41Postural instability (HP:0002172)3.02627105
42Congenital sensorineural hearing impairment (HP:0008527)3.01455272
43Amblyopia (HP:0000646)3.01283036
44Methylmalonic acidemia (HP:0002912)2.99665464
45Abnormality of the 1st metacarpal (HP:0010009)2.99117848
46Abnormality of the lower motor neuron (HP:0002366)2.98089715
47Abnormal eating behavior (HP:0100738)2.97235376
48Increased corneal curvature (HP:0100692)2.92573594
49Keratoconus (HP:0000563)2.92573594
50Scanning speech (HP:0002168)2.91794801
51Conjunctival hamartoma (HP:0100780)2.90734125
52Severe visual impairment (HP:0001141)2.88854793
53Genetic anticipation (HP:0003743)2.82933108
54Abnormality of cochlea (HP:0000375)2.82189802
55Abnormality of the proximal phalanges of the hand (HP:0009834)2.81822412
56Asplenia (HP:0001746)2.80145293
57Torticollis (HP:0000473)2.79933072
58Hamartoma of the eye (HP:0010568)2.79095149
59Papilledema (HP:0001085)2.78914729
60Abnormality of the phalanges of the 2nd finger (HP:0009541)2.77652577
61Urinary urgency (HP:0000012)2.76701222
62Abnormality of homocysteine metabolism (HP:0010919)2.76647118
63Homocystinuria (HP:0002156)2.76647118
64Short hallux (HP:0010109)2.75123015
65Annular pancreas (HP:0001734)2.71671315
66Mutism (HP:0002300)2.70394059
67Stereotypic behavior (HP:0000733)2.68015185
68Decreased central vision (HP:0007663)2.67537236
69Intention tremor (HP:0002080)2.66271807
70Hemiplegia (HP:0002301)2.65871992
71Ventricular fibrillation (HP:0001663)2.64287422
72Abnormality of ocular smooth pursuit (HP:0000617)2.63687078
73Focal dystonia (HP:0004373)2.63620594
74Spastic gait (HP:0002064)2.63321780
75Aplasia/Hypoplasia of the spleen (HP:0010451)2.63288623
76Dysmetric saccades (HP:0000641)2.63286091
77Abnormality of secondary sexual hair (HP:0009888)2.63192875
78Abnormality of the axillary hair (HP:0100134)2.63192875
79Short phalanx of the thumb (HP:0009660)2.60812063
80Hemiparesis (HP:0001269)2.60515665
81Long nose (HP:0003189)2.60165161
82Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.59091398
83Furrowed tongue (HP:0000221)2.59069999
84Diplopia (HP:0000651)2.56630808
85Abnormality of binocular vision (HP:0011514)2.56630808
86Impaired vibratory sensation (HP:0002495)2.54216872
87Short 4th metacarpal (HP:0010044)2.53151808
88Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.53151808
89Aplasia/Hypoplasia of the hallux (HP:0008362)2.51590852
90Goiter (HP:0000853)2.50197365
91Status epilepticus (HP:0002133)2.50038609
92Septo-optic dysplasia (HP:0100842)2.49916064
93Progressive inability to walk (HP:0002505)2.49601484
94Excessive salivation (HP:0003781)2.49574857
95Drooling (HP:0002307)2.49574857
96Bone cyst (HP:0012062)2.49510762
97Insidious onset (HP:0003587)2.48814731
98Termporal pattern (HP:0011008)2.48814731
99Bradykinesia (HP:0002067)2.47151114
100Abnormality of the middle phalanges of the toes (HP:0010183)2.45129780
101Epileptiform EEG discharges (HP:0011182)2.43763723
102Carpal bone hypoplasia (HP:0001498)2.43026853
103Abnormality of the phalanges of the 5th finger (HP:0004213)2.39250681
104Fetal akinesia sequence (HP:0001989)2.38973056
105Abnormality of the renal collecting system (HP:0004742)2.38005366
106Cerebral inclusion bodies (HP:0100314)2.37666000
107Restlessness (HP:0000711)2.36558681
108Morphological abnormality of the inner ear (HP:0011390)2.36301691
109Stenosis of the external auditory canal (HP:0000402)2.35547225
110Neurofibrillary tangles (HP:0002185)2.34265018
111Meningioma (HP:0002858)2.30755062
112Methylmalonic aciduria (HP:0012120)2.30393728
113Craniofacial dystonia (HP:0012179)2.29834763
114EEG with generalized epileptiform discharges (HP:0011198)2.29390618
115Synostosis of carpal bones (HP:0005048)2.28066956
116Megalencephaly (HP:0001355)2.26882156
117Absent speech (HP:0001344)2.23075190
118Short femoral neck (HP:0100864)2.22975417
119Nephronophthisis (HP:0000090)2.22000117
120Cystic liver disease (HP:0006706)2.21671490
121Congenital, generalized hypertrichosis (HP:0004540)2.20921013
122Truncal obesity (HP:0001956)2.20473147
123Chorioretinal atrophy (HP:0000533)2.20257708
124Tinnitus (HP:0000360)2.18024284
125Abnormal rod and cone electroretinograms (HP:0008323)2.17508159
126Hypsarrhythmia (HP:0002521)2.16723958
127Pheochromocytoma (HP:0002666)2.15051822
128Pointed chin (HP:0000307)2.13874088
129Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.13586752
130Lower limb muscle weakness (HP:0007340)2.13234724
131Inability to walk (HP:0002540)2.13089940
1323-Methylglutaconic aciduria (HP:0003535)2.12510872
133Incomplete penetrance (HP:0003829)2.11990581
134Abnormality of the corticospinal tract (HP:0002492)2.11952306
135Abnormality of DNA repair (HP:0003254)2.11068197
136Aplasia/Hypoplasia of the tibia (HP:0005772)2.09980794
137Gait ataxia (HP:0002066)2.07571327
138Congenital stationary night blindness (HP:0007642)2.07261335
139Myotonia (HP:0002486)2.06168797
140Optic nerve hypoplasia (HP:0000609)2.05999249
141Irregular vertebral endplates (HP:0003301)2.03493324
142Hypoplastic pelvis (HP:0008839)2.02623164
143Limb dystonia (HP:0002451)2.02069246
144Type II lissencephaly (HP:0007260)2.01587846
145Generalized myoclonic seizures (HP:0002123)2.01331270
146Bundle branch block (HP:0011710)2.00433806
147Clumsiness (HP:0002312)2.00293635
148Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.98901792
149Lower limb asymmetry (HP:0100559)1.97024385
150Resting tremor (HP:0002322)1.95643486
151Insomnia (HP:0100785)1.95288799
152Abnormality of saccadic eye movements (HP:0000570)1.95084739
153Small hand (HP:0200055)1.94682638
154Synostosis involving the elbow (HP:0003938)1.93371866
155Humeroradial synostosis (HP:0003041)1.93371866
156Neuronal loss in central nervous system (HP:0002529)1.92192616
157Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.91142620
158Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.91137771
159Gonadotropin excess (HP:0000837)1.90820288
160Lower limb amyotrophy (HP:0007210)1.90531251
161Mesomelia (HP:0003027)1.88979044
162Abnormality of the 4th metacarpal (HP:0010012)1.88169293
163Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.88143816
164Clonus (HP:0002169)1.87702471
165Fused cervical vertebrae (HP:0002949)1.87113233
166Thyroid-stimulating hormone excess (HP:0002925)1.86556709
167Abnormal EKG (HP:0003115)1.85378505
168Symphalangism affecting the phalanges of the hand (HP:0009773)1.84551085
169Short tibia (HP:0005736)1.84212988
170Delusions (HP:0000746)1.83880674
171Absent thumb (HP:0009777)1.82591625
172Abnormality of the columella (HP:0009929)1.82420534
173Agitation (HP:0000713)1.82338164
174Neuroendocrine neoplasm (HP:0100634)1.81126015
175Obstructive sleep apnea (HP:0002870)1.80643119
176Polyphagia (HP:0002591)1.79708910
177Psychosis (HP:0000709)1.79257044
178Blue irides (HP:0000635)1.79033478
179Rigidity (HP:0002063)1.76378236
180Amyotrophic lateral sclerosis (HP:0007354)1.76313777
181Rapidly progressive (HP:0003678)1.71291704
182Abnormality of salivation (HP:0100755)1.69671719
183Failure to thrive in infancy (HP:0001531)1.68975635
184Limb ataxia (HP:0002070)1.67259810
185Protruding tongue (HP:0010808)1.65028056
186Deeply set eye (HP:0000490)1.64561728

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.93197918
2FRK4.71128871
3NTRK34.55663010
4GRK14.44460393
5MAP3K93.93226431
6ADRBK23.93011438
7DAPK22.94076127
8MAP3K42.79877118
9MINK12.63129267
10RIPK42.47581040
11PRKD32.29317197
12PAK62.27142347
13MAP2K72.23640573
14KSR22.22408202
15TAOK32.18548857
16MARK12.16344976
17TLK12.04980217
18CAMKK12.01365318
19NTRK11.93512114
20NTRK21.85717056
21TAF11.83452484
22DAPK11.82665723
23MAP3K121.81796966
24MAP2K41.79893971
25BMPR1B1.75530474
26NUAK11.73352651
27ACVR1B1.70686548
28CASK1.68292208
29SIK21.61149334
30CDK51.60172523
31INSRR1.59289172
32GRK61.58274478
33TNIK1.56184045
34CDK191.53650064
35KSR11.53580329
36STK381.50480238
37ARAF1.49961336
38GRK51.46607771
39PRPF4B1.39118198
40CDC71.38253405
41PLK21.35891543
42MAP3K131.33416307
43ZAK1.32332541
44FES1.29160122
45PRKCG1.26657557
46CAMKK21.25290967
47TAOK11.23873787
48TYRO31.21064669
49MAP4K21.19318101
50MAP3K21.19205014
51MAPK131.16737435
52PNCK1.16619694
53ERBB21.15479084
54PINK11.05784863
55UHMK11.03444354
56CAMK11.00245470
57CAMK2A0.98236331
58WNK30.95956304
59AKT30.95312223
60STK110.94941516
61ADRBK10.93845722
62BMPR20.92882657
63SGK2230.92211292
64SGK4940.92211292
65PTK2B0.91976103
66FGFR20.91813798
67BLK0.91627898
68RAF10.90644245
69CDK180.90415494
70CDK150.89096995
71CSNK1G10.87817782
72PRKCH0.85562280
73CDK140.84565046
74CAMK2B0.84555261
75PHKG10.83720930
76PHKG20.83720930
77CSNK1A1L0.82367445
78OXSR10.82031530
79TXK0.79120780
80CSNK1G30.79069052
81PDK10.78321728
82RET0.78114649
83CDK11A0.77570814
84SGK20.76305319
85CSNK1A10.76123220
86DYRK20.75714261
87SGK10.74993432
88LATS20.74916115
89MAPKAPK50.74444797
90TNK20.74269238
91LMTK20.73278484
92PDPK10.73129838
93MAPK150.72882123
94TIE10.72277549
95GRK70.70441033
96ALK0.68289811
97RPS6KA60.67180453
98VRK10.67038795
99SGK30.66853799
100MAPK40.65002692
101PAK30.62467027
102WNK40.60497006
103MARK20.60382818
104DYRK1A0.60041123
105RPS6KA50.59677716
106STK240.59595208
107CDK90.59002035
108BRAF0.57876281
109PRKD10.57549526
110WNK10.57371780
111FLT30.57183956
112RIPK10.56983300
113STK390.56587268
114VRK20.56536230
115MKNK20.56067660
116TEC0.54881089
117CAMK40.54189924
118IKBKB0.53661673
119MAP3K10.53475118
120CLK10.52820650
121NEK60.52729092
122RPS6KA30.50454132
123CAMK2D0.50162886
124CDC42BPA0.50110833
125PKN10.50069593
126MAP3K70.49059762
127IGF1R0.48819833
128PRKCZ0.48692202
129DAPK30.47798733
130CAMK2G0.47174198
131NME10.46184745
132MAPK100.45474574
133CDK30.45102645
134STK38L0.44855826
135PRKACA0.44775348
136CAMK1D0.44241539
137FYN0.44110925
138CAMK1G0.44102113
139FGR0.43782032
140CSNK1G20.43337496
141BRSK10.43258824
142MAP2K60.42692459
143CCNB10.42599068
144CSNK1D0.42593192
145NLK0.40463497
146SIK30.40229098
147PRKCE0.39952438
148DMPK0.38847317
149MAP2K20.36638942
150MAP2K10.36630767
151NEK90.35782246
152ROCK20.34517104
153FER0.32245245
154PRKCB0.32119425
155PRKD20.31999039
156PRKCA0.30348575

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.77950201
2Synaptic vesicle cycle_Homo sapiens_hsa047213.28701780
3Olfactory transduction_Homo sapiens_hsa047402.94354505
4Long-term potentiation_Homo sapiens_hsa047202.83882985
5Circadian entrainment_Homo sapiens_hsa047132.76944546
6Glutamatergic synapse_Homo sapiens_hsa047242.70193944
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.68232404
8GABAergic synapse_Homo sapiens_hsa047272.64024031
9Amphetamine addiction_Homo sapiens_hsa050312.55406653
10Morphine addiction_Homo sapiens_hsa050322.54986558
11Salivary secretion_Homo sapiens_hsa049702.32001291
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.26410754
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.19110079
14Dopaminergic synapse_Homo sapiens_hsa047282.16955589
15Melanoma_Homo sapiens_hsa052182.06010926
16Insulin secretion_Homo sapiens_hsa049112.04094454
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.03340286
18Gastric acid secretion_Homo sapiens_hsa049711.97804092
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.94790062
20Cholinergic synapse_Homo sapiens_hsa047251.93992956
21Taste transduction_Homo sapiens_hsa047421.82600876
22Long-term depression_Homo sapiens_hsa047301.74786986
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.74756220
24Oxytocin signaling pathway_Homo sapiens_hsa049211.72914363
25Homologous recombination_Homo sapiens_hsa034401.72146654
26Calcium signaling pathway_Homo sapiens_hsa040201.70498355
27Renin secretion_Homo sapiens_hsa049241.66491684
28Cocaine addiction_Homo sapiens_hsa050301.60901802
29Serotonergic synapse_Homo sapiens_hsa047261.55682658
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.54799696
31GnRH signaling pathway_Homo sapiens_hsa049121.48799189
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45472365
33Basal cell carcinoma_Homo sapiens_hsa052171.42500333
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38388361
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.37218998
36cAMP signaling pathway_Homo sapiens_hsa040241.35063739
37Collecting duct acid secretion_Homo sapiens_hsa049661.34561854
38Gap junction_Homo sapiens_hsa045401.34557938
39Selenocompound metabolism_Homo sapiens_hsa004501.33718786
40Vitamin digestion and absorption_Homo sapiens_hsa049771.28315686
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28204549
42Sulfur metabolism_Homo sapiens_hsa009201.28071199
43Hedgehog signaling pathway_Homo sapiens_hsa043401.24948289
44Glycerolipid metabolism_Homo sapiens_hsa005611.24023550
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23971872
46Linoleic acid metabolism_Homo sapiens_hsa005911.23186806
47Type II diabetes mellitus_Homo sapiens_hsa049301.19974889
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15420737
49Tryptophan metabolism_Homo sapiens_hsa003801.14909866
50Estrogen signaling pathway_Homo sapiens_hsa049151.14581089
51Nitrogen metabolism_Homo sapiens_hsa009101.14379980
52Glioma_Homo sapiens_hsa052141.14110587
53Renin-angiotensin system_Homo sapiens_hsa046141.12445835
54Chemical carcinogenesis_Homo sapiens_hsa052041.11938604
55cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08226526
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03827284
57Melanogenesis_Homo sapiens_hsa049161.03130685
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01049555
59Cardiac muscle contraction_Homo sapiens_hsa042601.00301206
60ErbB signaling pathway_Homo sapiens_hsa040120.98931682
61Axon guidance_Homo sapiens_hsa043600.97050232
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.96235256
63Pancreatic secretion_Homo sapiens_hsa049720.94955003
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92383551
65Oocyte meiosis_Homo sapiens_hsa041140.90183864
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.89645727
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87600221
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83774093
69Thyroid hormone synthesis_Homo sapiens_hsa049180.82090113
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80627578
71Vibrio cholerae infection_Homo sapiens_hsa051100.79338503
72Phototransduction_Homo sapiens_hsa047440.77117057
73Dorso-ventral axis formation_Homo sapiens_hsa043200.75825103
74Choline metabolism in cancer_Homo sapiens_hsa052310.74256189
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73886489
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.72661566
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72433069
78Dilated cardiomyopathy_Homo sapiens_hsa054140.72001106
79Ether lipid metabolism_Homo sapiens_hsa005650.70630539
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69171829
81VEGF signaling pathway_Homo sapiens_hsa043700.69063354
82Primary immunodeficiency_Homo sapiens_hsa053400.68499731
83MAPK signaling pathway_Homo sapiens_hsa040100.68127783
84DNA replication_Homo sapiens_hsa030300.67582642
85Fanconi anemia pathway_Homo sapiens_hsa034600.66808213
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66010833
87Systemic lupus erythematosus_Homo sapiens_hsa053220.64574986
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62781487
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62379264
90Inositol phosphate metabolism_Homo sapiens_hsa005620.60034280
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.59821077
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.59141713
93Retinol metabolism_Homo sapiens_hsa008300.58655978
94Rap1 signaling pathway_Homo sapiens_hsa040150.58469400
95Glucagon signaling pathway_Homo sapiens_hsa049220.58402145
96Hippo signaling pathway_Homo sapiens_hsa043900.55475658
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.54772556
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54553850
99Ras signaling pathway_Homo sapiens_hsa040140.53963389
100TGF-beta signaling pathway_Homo sapiens_hsa043500.53760512
101Bile secretion_Homo sapiens_hsa049760.53685400
102Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52368723
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52260801
104mTOR signaling pathway_Homo sapiens_hsa041500.49311871
105ECM-receptor interaction_Homo sapiens_hsa045120.48554507
106Basal transcription factors_Homo sapiens_hsa030220.48004244
107Fatty acid biosynthesis_Homo sapiens_hsa000610.46715093
108Endocytosis_Homo sapiens_hsa041440.46509430
109Non-small cell lung cancer_Homo sapiens_hsa052230.46045441
110Alcoholism_Homo sapiens_hsa050340.44778318
111MicroRNAs in cancer_Homo sapiens_hsa052060.44430242
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.44278699
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43312834
114African trypanosomiasis_Homo sapiens_hsa051430.43280419
115Type I diabetes mellitus_Homo sapiens_hsa049400.42558902
116ABC transporters_Homo sapiens_hsa020100.42431991
117RNA degradation_Homo sapiens_hsa030180.42148906
118Circadian rhythm_Homo sapiens_hsa047100.41758349
119Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40495386
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40291744
121Asthma_Homo sapiens_hsa053100.39851524
122Prion diseases_Homo sapiens_hsa050200.39553187
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39045964
124Protein digestion and absorption_Homo sapiens_hsa049740.37888293
125Ovarian steroidogenesis_Homo sapiens_hsa049130.37830200
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37500041
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37428400
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37384177
129Insulin signaling pathway_Homo sapiens_hsa049100.35551444
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35155270
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34929037
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34928578
133Endometrial cancer_Homo sapiens_hsa052130.34515671
134Chemokine signaling pathway_Homo sapiens_hsa040620.34200923
135Wnt signaling pathway_Homo sapiens_hsa043100.34187638
136Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34099347
137Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33971534
138Renal cell carcinoma_Homo sapiens_hsa052110.32887451
139Alzheimers disease_Homo sapiens_hsa050100.30915520
140Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30344932
141Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28205337
142Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27288883
143Glycerophospholipid metabolism_Homo sapiens_hsa005640.25509173

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