PCNX4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.89087533
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.76376854
3synaptic vesicle maturation (GO:0016188)5.40384463
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.27679404
5neuron cell-cell adhesion (GO:0007158)5.24613267
6glutamate secretion (GO:0014047)5.16726370
7response to pheromone (GO:0019236)5.04928910
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.99877853
9regulation of synaptic vesicle exocytosis (GO:2000300)4.98585008
10protein localization to synapse (GO:0035418)4.97224496
11vocalization behavior (GO:0071625)4.89980514
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.67230898
13locomotory exploration behavior (GO:0035641)4.59956578
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.49870633
15regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.43657790
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.40209290
17regulation of glutamate receptor signaling pathway (GO:1900449)4.38895983
18regulation of synaptic vesicle transport (GO:1902803)4.35318811
19synaptic transmission, glutamatergic (GO:0035249)4.31248806
20glutamate receptor signaling pathway (GO:0007215)4.30923763
21neuron-neuron synaptic transmission (GO:0007270)4.27448778
22neurotransmitter secretion (GO:0007269)4.21708272
23gamma-aminobutyric acid signaling pathway (GO:0007214)4.12536186
24G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.09217372
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.09148724
26layer formation in cerebral cortex (GO:0021819)4.08332552
27pyrimidine nucleobase catabolic process (GO:0006208)4.01087994
28neuron recognition (GO:0008038)4.00832121
29exploration behavior (GO:0035640)3.98636824
30neurotransmitter-gated ion channel clustering (GO:0072578)3.97176575
31axonal fasciculation (GO:0007413)3.90130984
32neural tube formation (GO:0001841)3.87436654
33regulation of long-term neuronal synaptic plasticity (GO:0048169)3.83862458
34neuronal action potential propagation (GO:0019227)3.78528439
35synaptic vesicle endocytosis (GO:0048488)3.77019943
36positive regulation of synapse maturation (GO:0090129)3.75892310
37transmission of nerve impulse (GO:0019226)3.75353800
38proline transport (GO:0015824)3.71665513
39cellular potassium ion homeostasis (GO:0030007)3.67357767
40regulation of synapse structural plasticity (GO:0051823)3.63446952
41regulation of neuronal synaptic plasticity (GO:0048168)3.61371594
42innervation (GO:0060384)3.59532030
43long-term synaptic potentiation (GO:0060291)3.58861145
44regulation of excitatory postsynaptic membrane potential (GO:0060079)3.57757475
45regulation of postsynaptic membrane potential (GO:0060078)3.56952917
46neurotransmitter transport (GO:0006836)3.56783193
47startle response (GO:0001964)3.55829888
48epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.47544173
49gamma-aminobutyric acid transport (GO:0015812)3.46841246
50long-term memory (GO:0007616)3.45301091
51positive regulation of membrane potential (GO:0045838)3.42207659
52negative regulation of synaptic transmission, GABAergic (GO:0032229)3.38104806
53postsynaptic membrane organization (GO:0001941)3.37492562
54nonmotile primary cilium assembly (GO:0035058)3.37426919
55membrane hyperpolarization (GO:0060081)3.36564302
56mating behavior (GO:0007617)3.35109604
57synapse assembly (GO:0007416)3.34928448
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.34688054
59regulation of vesicle fusion (GO:0031338)3.31615058
60regulation of synaptic transmission, glutamatergic (GO:0051966)3.31309184
61presynaptic membrane assembly (GO:0097105)3.31023929
62behavioral defense response (GO:0002209)3.29962317
63behavioral fear response (GO:0001662)3.29962317
64regulation of neurotransmitter secretion (GO:0046928)3.29566463
65cilium or flagellum-dependent cell motility (GO:0001539)3.29529607
66regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.28031851
67epithelial cilium movement (GO:0003351)3.26362049
68response to histamine (GO:0034776)3.26098949
69establishment of protein localization to Golgi (GO:0072600)3.26093637
70dendritic spine morphogenesis (GO:0060997)3.25861510
71positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.25547647
72negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.24729328
73cerebellar granule cell differentiation (GO:0021707)3.22392408
74activation of protein kinase A activity (GO:0034199)3.21624766
75fear response (GO:0042596)3.18222809
76regulation of synaptic plasticity (GO:0048167)3.17335237
77positive regulation of synaptic transmission, GABAergic (GO:0032230)3.16902374
78regulation of neurotransmitter levels (GO:0001505)3.15943764
79cilium morphogenesis (GO:0060271)3.15149043
80nucleobase catabolic process (GO:0046113)3.12645420
81behavioral response to nicotine (GO:0035095)3.12487192
82striatum development (GO:0021756)3.10825827
83intraciliary transport (GO:0042073)3.09690768
84positive regulation of synapse assembly (GO:0051965)3.08729755
85cilium organization (GO:0044782)3.08102528
86cilium movement (GO:0003341)3.08044382
87synaptic vesicle transport (GO:0048489)3.08025254
88establishment of synaptic vesicle localization (GO:0097480)3.08025254
89microtubule anchoring (GO:0034453)3.07650233
90cilium assembly (GO:0042384)3.07539780
91neuromuscular process controlling posture (GO:0050884)3.06838273
92dendrite development (GO:0016358)3.05148530
93regulation of neurotransmitter transport (GO:0051588)3.04827965
94dendrite morphogenesis (GO:0048813)3.03196574
95presynaptic membrane organization (GO:0097090)3.02648178
96regulation of dendritic spine morphogenesis (GO:0061001)3.02070186
97membrane depolarization (GO:0051899)2.98620981
98cerebellar Purkinje cell differentiation (GO:0021702)2.98345795
99establishment of nucleus localization (GO:0040023)2.98081628
100sodium ion export (GO:0071436)2.97613120
101synaptic transmission (GO:0007268)2.96312461
102membrane depolarization during action potential (GO:0086010)2.95281631
103behavioral response to cocaine (GO:0048148)2.94540506
104limb development (GO:0060173)2.94464538
105appendage development (GO:0048736)2.94464538
106behavioral response to ethanol (GO:0048149)2.91715589
107regulation of female receptivity (GO:0045924)2.91670126
108central nervous system projection neuron axonogenesis (GO:0021952)2.90185525
109learning (GO:0007612)2.89513388
110synapse organization (GO:0050808)2.88915987
111regulation of synapse maturation (GO:0090128)2.88517789
112central nervous system neuron axonogenesis (GO:0021955)2.87080177
113positive regulation of dendritic spine morphogenesis (GO:0061003)2.86939317
114positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.85983944
115regulation of respiratory system process (GO:0044065)2.85147525
116regulation of protein kinase A signaling (GO:0010738)2.80613722
117protein targeting to Golgi (GO:0000042)2.80455516
118calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.80048728
119regulation of synaptic transmission, GABAergic (GO:0032228)2.79699592
120establishment of vesicle localization (GO:0051650)2.79052701
121social behavior (GO:0035176)2.78952534
122intraspecies interaction between organisms (GO:0051703)2.78952534
123regulation of hippo signaling (GO:0035330)2.78839725
124cytoplasmic mRNA processing body assembly (GO:0033962)2.77389437
125interkinetic nuclear migration (GO:0022027)2.74806434
126protein localization to cilium (GO:0061512)2.72395710
127protein prenylation (GO:0018342)2.71988069
128prenylation (GO:0097354)2.71988069
129negative regulation of axon guidance (GO:1902668)2.71171057
130retinal ganglion cell axon guidance (GO:0031290)2.69429593
131limb bud formation (GO:0060174)2.67260639
132nucleus localization (GO:0051647)2.67212422
133negative regulation of translation, ncRNA-mediated (GO:0040033)2.64311064
134regulation of translation, ncRNA-mediated (GO:0045974)2.64311064
135negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.64311064
136olfactory bulb development (GO:0021772)2.63568603
137negative regulation of cytosolic calcium ion concentration (GO:0051481)2.62747771
138monoubiquitinated protein deubiquitination (GO:0035520)2.62587136
139hindbrain development (GO:0030902)2.61531291
140retrograde transport, vesicle recycling within Golgi (GO:0000301)2.55361375
141cellular component assembly involved in morphogenesis (GO:0010927)2.52331101
142smoothened signaling pathway (GO:0007224)2.51573607
143regulation of pigment cell differentiation (GO:0050932)2.49542717
144somite development (GO:0061053)2.47043256
145protein localization to Golgi apparatus (GO:0034067)2.46953283
146positive regulation of developmental pigmentation (GO:0048087)2.46916989
147cerebral cortex radially oriented cell migration (GO:0021799)2.44717403
148forebrain neuron differentiation (GO:0021879)2.41042990
149photoreceptor cell maintenance (GO:0045494)2.39708912
150regulation of telomere maintenance (GO:0032204)2.37694032
151detection of light stimulus involved in visual perception (GO:0050908)2.34480711
152detection of light stimulus involved in sensory perception (GO:0050962)2.34480711
153inner ear receptor stereocilium organization (GO:0060122)2.34362203
154regulation of axon guidance (GO:1902667)2.34132697
155artery development (GO:0060840)2.33287256
156axonemal dynein complex assembly (GO:0070286)2.32219321
157cerebral cortex cell migration (GO:0021795)2.31921790
158pericardium development (GO:0060039)2.31517492
159regulation of cilium movement (GO:0003352)2.31161213
160sympathetic nervous system development (GO:0048485)2.31129909
161snRNA transcription (GO:0009301)2.30783454
162microtubule depolymerization (GO:0007019)2.29132529
163DNA double-strand break processing (GO:0000729)2.25889197
164positive regulation of mRNA processing (GO:0050685)2.25461676
165negative regulation of oligodendrocyte differentiation (GO:0048715)2.25382891
166homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.23852030
167regulation of DNA endoreduplication (GO:0032875)2.23466713
168negative regulation of axon extension involved in axon guidance (GO:0048843)2.23367580
169retina layer formation (GO:0010842)2.23007400
170regulation of synapse assembly (GO:0051963)2.22937546
171spinal cord development (GO:0021510)2.22779127
172L-fucose catabolic process (GO:0042355)2.22655573
173fucose catabolic process (GO:0019317)2.22655573
174L-fucose metabolic process (GO:0042354)2.22655573
175axoneme assembly (GO:0035082)2.21919707
176spinal cord motor neuron differentiation (GO:0021522)2.21806045
177kidney morphogenesis (GO:0060993)2.18776938
178retinal cone cell development (GO:0046549)2.17893865
179auditory behavior (GO:0031223)2.16107951
180embryonic foregut morphogenesis (GO:0048617)2.16072028
181positive regulation of mitochondrial fission (GO:0090141)2.15082932
182positive regulation of cardiac muscle cell differentiation (GO:2000727)2.14692435
183hippocampus development (GO:0021766)2.14591587
184histone H3-K9 methylation (GO:0051567)2.14505603

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.07785720
2GBX2_23144817_ChIP-Seq_PC3_Human3.89688143
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.31714329
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.99163081
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.92879341
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89696954
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.88238336
8REST_21632747_ChIP-Seq_MESCs_Mouse2.57726796
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51330707
10TAF15_26573619_Chip-Seq_HEK293_Human2.46323667
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43960952
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.42455957
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42325948
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42325948
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.38003336
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37855081
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.33404170
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.23016884
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.23003080
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.22088112
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21025118
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.19411874
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19033466
24RARB_27405468_Chip-Seq_BRAIN_Mouse2.14074349
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.13118396
26CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11463990
27ZFP57_27257070_Chip-Seq_ESCs_Mouse2.03643570
28RNF2_27304074_Chip-Seq_ESCs_Mouse2.01531906
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01407546
30EZH2_27294783_Chip-Seq_ESCs_Mouse2.00181771
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97064201
32AR_21572438_ChIP-Seq_LNCaP_Human1.95726942
33DROSHA_22980978_ChIP-Seq_HELA_Human1.93728061
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.90401331
35FUS_26573619_Chip-Seq_HEK293_Human1.87620823
36SMAD4_21799915_ChIP-Seq_A2780_Human1.85403254
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82368161
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81212414
39P300_19829295_ChIP-Seq_ESCs_Human1.76303728
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.73662350
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70493935
42IGF1R_20145208_ChIP-Seq_DFB_Human1.69207080
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.64183094
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61728134
45ZNF274_21170338_ChIP-Seq_K562_Hela1.61568372
46VDR_22108803_ChIP-Seq_LS180_Human1.61532445
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.59855371
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59726358
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53197394
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52868296
51RNF2_27304074_Chip-Seq_NSC_Mouse1.49020310
52TP53_16413492_ChIP-PET_HCT116_Human1.48685114
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48132969
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47131726
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.46749219
56AR_25329375_ChIP-Seq_VCAP_Human1.46257649
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43328626
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43278255
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43228167
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.42480318
61P53_22127205_ChIP-Seq_FIBROBLAST_Human1.37528399
62SOX2_21211035_ChIP-Seq_LN229_Gbm1.37495748
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.34827007
64STAT3_23295773_ChIP-Seq_U87_Human1.33861175
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.31682513
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28396539
67TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26946257
68POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26946257
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24786969
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24704796
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23125424
72JUN_21703547_ChIP-Seq_K562_Human1.22601829
73TCF4_23295773_ChIP-Seq_U87_Human1.22154184
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21614637
75NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21298158
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21051769
77KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.20554152
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.20317353
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.19601706
80IRF1_19129219_ChIP-ChIP_H3396_Human1.19425085
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19198328
82EWS_26573619_Chip-Seq_HEK293_Human1.18864567
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18587325
84STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.18383497
85P53_22387025_ChIP-Seq_ESCs_Mouse1.17068419
86AR_19668381_ChIP-Seq_PC3_Human1.16392953
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16029026
88KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15482931
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15038636
90RING1B_27294783_Chip-Seq_ESCs_Mouse1.14419170
91NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14396122
92NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14396122
93ERG_21242973_ChIP-ChIP_JURKAT_Human1.14311558
94KDM2B_26808549_Chip-Seq_REH_Human1.14068968
95TCF4_22108803_ChIP-Seq_LS180_Human1.13899923
96RUNX2_22187159_ChIP-Seq_PCA_Human1.13477519
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13411595
98ER_23166858_ChIP-Seq_MCF-7_Human1.13293769
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13211712
100E2F1_18555785_Chip-Seq_ESCs_Mouse1.13048366
101FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12828856
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11948675
103MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11464912
104AHR_22903824_ChIP-Seq_MCF-7_Human1.11178941
105TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10777242
106CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08114029
107CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.07315253
108TAL1_26923725_Chip-Seq_HPCs_Mouse1.06119331
109MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05655113
110NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04508466
111YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04159504
112EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03892300
113POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03813767
114NFE2_27457419_Chip-Seq_LIVER_Mouse1.03315469
115SOX9_26525672_Chip-Seq_HEART_Mouse1.03219909
116CMYC_18555785_Chip-Seq_ESCs_Mouse1.02534213
117ARNT_22903824_ChIP-Seq_MCF-7_Human1.02476293
118RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01447645
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98693638
120CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98292555
121SMAD3_21741376_ChIP-Seq_ESCs_Human0.97284401
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95791777
123RING1B_27294783_Chip-Seq_NPCs_Mouse0.95756670
124BCAT_22108803_ChIP-Seq_LS180_Human0.95221401
125PRDM14_20953172_ChIP-Seq_ESCs_Human0.93362548
126TP53_18474530_ChIP-ChIP_U2OS_Human0.93004020
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92743122
128TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91776667
129CBP_20019798_ChIP-Seq_JUKART_Human0.91774859
130IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91774859
131ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91670279
132FLI1_21867929_ChIP-Seq_TH2_Mouse0.89839451
133TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89219693
134NANOG_18555785_Chip-Seq_ESCs_Mouse0.88105154
135RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87370545
136GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86871863
137MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86851602

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.23764148
2MP0003880_abnormal_central_pattern4.49305187
3MP0003635_abnormal_synaptic_transmissio3.81445583
4MP0005423_abnormal_somatic_nervous3.13140906
5MP0009046_muscle_twitch3.10426437
6MP0004270_analgesia3.09215988
7MP0009745_abnormal_behavioral_response3.07010213
8MP0002063_abnormal_learning/memory/cond3.04069419
9MP0001968_abnormal_touch/_nociception3.01515480
10MP0002064_seizures2.95715194
11MP0002572_abnormal_emotion/affect_behav2.59571871
12MP0002734_abnormal_mechanical_nocicepti2.58815298
13MP0001984_abnormal_olfaction2.49542971
14MP0002736_abnormal_nociception_after2.46039436
15MP0002272_abnormal_nervous_system2.44834319
16MP0001486_abnormal_startle_reflex2.29863408
17MP0001440_abnormal_grooming_behavior2.24061934
18MP0006276_abnormal_autonomic_nervous2.22487558
19MP0002102_abnormal_ear_morphology2.16245627
20MP0002735_abnormal_chemical_nociception2.09679934
21MP0002184_abnormal_innervation1.99440197
22MP0003122_maternal_imprinting1.98624291
23MP0002067_abnormal_sensory_capabilities1.97661869
24MP0005551_abnormal_eye_electrophysiolog1.94592730
25MP0001501_abnormal_sleep_pattern1.93987881
26MP0000778_abnormal_nervous_system1.87890894
27MP0002234_abnormal_pharynx_morphology1.86802194
28MP0001529_abnormal_vocalization1.83400514
29MP0002733_abnormal_thermal_nociception1.76195932
30MP0001970_abnormal_pain_threshold1.73991767
31MP0004924_abnormal_behavior1.72145129
32MP0005386_behavior/neurological_phenoty1.72145129
33MP0002557_abnormal_social/conspecific_i1.69866211
34MP0009780_abnormal_chondrocyte_physiolo1.68296318
35MP0000427_abnormal_hair_cycle1.67379042
36MP0003937_abnormal_limbs/digits/tail_de1.65414479
37MP0008057_abnormal_DNA_replication1.62876108
38MP0008569_lethality_at_weaning1.59523231
39MP0002009_preneoplasia1.58429638
40MP0002822_catalepsy1.55409429
41MP0004811_abnormal_neuron_physiology1.54751118
42MP0005646_abnormal_pituitary_gland1.54019199
43MP0002882_abnormal_neuron_morphology1.52841915
44MP0002909_abnormal_adrenal_gland1.51084243
45MP0000955_abnormal_spinal_cord1.49040306
46MP0003329_amyloid_beta_deposits1.47454827
47MP0001502_abnormal_circadian_rhythm1.47185938
48MP0001905_abnormal_dopamine_level1.46230157
49MP0004133_heterotaxia1.42937622
50MP0000383_abnormal_hair_follicle1.40864713
51MP0002066_abnormal_motor_capabilities/c1.34771888
52MP0004885_abnormal_endolymph1.34612949
53MP0004142_abnormal_muscle_tone1.34112432
54MP0003123_paternal_imprinting1.33909759
55MP0005248_abnormal_Harderian_gland1.32484530
56MP0003879_abnormal_hair_cell1.32238838
57MP0005645_abnormal_hypothalamus_physiol1.31618409
58MP0001293_anophthalmia1.30314606
59MP0003385_abnormal_body_wall1.29655373
60MP0005499_abnormal_olfactory_system1.28825131
61MP0005394_taste/olfaction_phenotype1.28825131
62MP0002090_abnormal_vision1.24967798
63MP0000631_abnormal_neuroendocrine_gland1.24791662
64MP0002152_abnormal_brain_morphology1.21865804
65MP0002233_abnormal_nose_morphology1.21537637
66MP0002938_white_spotting1.21357385
67MP0006072_abnormal_retinal_apoptosis1.21257693
68MP0001188_hyperpigmentation1.20466995
69MP0003950_abnormal_plasma_membrane1.19877309
70MP0003755_abnormal_palate_morphology1.19439772
71MP0000013_abnormal_adipose_tissue1.18797536
72MP0004043_abnormal_pH_regulation1.18614751
73MP0003119_abnormal_digestive_system1.18316081
74MP0002928_abnormal_bile_duct1.15339735
75MP0004858_abnormal_nervous_system1.14943853
76MP0003787_abnormal_imprinting1.14705676
77MP0001286_abnormal_eye_development1.14685610
78MP0003283_abnormal_digestive_organ1.13676144
79MP0005391_vision/eye_phenotype1.12453135
80MP0003935_abnormal_craniofacial_develop1.11641045
81MP0002876_abnormal_thyroid_physiology1.10018914
82MP0000647_abnormal_sebaceous_gland1.09885219
83MP0003121_genomic_imprinting1.09324099
84MP0002229_neurodegeneration1.07165286
85MP0000537_abnormal_urethra_morphology1.06305103
86MP0006292_abnormal_olfactory_placode1.04100499
87MP0005171_absent_coat_pigmentation1.03620817
88MP0005367_renal/urinary_system_phenotyp1.03080422
89MP0000516_abnormal_urinary_system1.03080422
90MP0003633_abnormal_nervous_system1.02709164
91MP0009697_abnormal_copulation1.02312154
92MP0002752_abnormal_somatic_nervous1.02088692
93MP0002638_abnormal_pupillary_reflex1.01652194
94MP0002837_dystrophic_cardiac_calcinosis1.00866310
95MP0005503_abnormal_tendon_morphology1.00742832
96MP0000428_abnormal_craniofacial_morphol0.96520182
97MP0006054_spinal_hemorrhage0.96000019
98MP0003567_abnormal_fetal_cardiomyocyte0.95825778
99MP0002697_abnormal_eye_size0.95545642
100MP0000569_abnormal_digit_pigmentation0.95140338
101MP0001177_atelectasis0.94243526
102MP0003631_nervous_system_phenotype0.91266592
103MP0001963_abnormal_hearing_physiology0.90417197
104MP0005253_abnormal_eye_physiology0.89801158
105MP0002069_abnormal_eating/drinking_beha0.87455211
106MP0000751_myopathy0.86540346
107MP0004742_abnormal_vestibular_system0.86469180
108MP0003942_abnormal_urinary_system0.86205221
109MP0008789_abnormal_olfactory_epithelium0.85428984
110MP0002109_abnormal_limb_morphology0.85231233
111MP0010386_abnormal_urinary_bladder0.84945818
112MP0010678_abnormal_skin_adnexa0.83950886
113MP0001324_abnormal_eye_pigmentation0.83359610
114MP0002084_abnormal_developmental_patter0.82742731
115MP0004197_abnormal_fetal_growth/weight/0.82500272
116MP0000049_abnormal_middle_ear0.82321276
117MP0003634_abnormal_glial_cell0.81922500
118MP0003943_abnormal_hepatobiliary_system0.81723051
119MP0004085_abnormal_heartbeat0.81251681
120MP0005623_abnormal_meninges_morphology0.81221176
121MP0010094_abnormal_chromosome_stability0.80929994
122MP0001299_abnormal_eye_distance/0.79731759
123MP0002177_abnormal_outer_ear0.79204047
124MP0002653_abnormal_ependyma_morphology0.78575419
125MP0008872_abnormal_physiological_respon0.78179781
126MP0003861_abnormal_nervous_system0.77670477
127MP0005195_abnormal_posterior_eye0.76373099
128MP0004233_abnormal_muscle_weight0.72918645
129MP0002751_abnormal_autonomic_nervous0.72447795
130MP0005187_abnormal_penis_morphology0.71349927
131MP0001485_abnormal_pinna_reflex0.70830220
132MP0000534_abnormal_ureter_morphology0.69089147
133MP0004145_abnormal_muscle_electrophysio0.68827605
134MP0003632_abnormal_nervous_system0.68151225
135MP0001348_abnormal_lacrimal_gland0.64560078
136MP0000026_abnormal_inner_ear0.63417322
137MP0008877_abnormal_DNA_methylation0.60804679
138MP0001943_abnormal_respiration0.60796511
139MP0003137_abnormal_impulse_conducting0.60774976
140MP0003890_abnormal_embryonic-extraembry0.60677362
141MP0001664_abnormal_digestion0.59650811
142MP0001986_abnormal_taste_sensitivity0.58926534
143MP0003698_abnormal_male_reproductive0.58553712

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.53741187
2Atonic seizures (HP:0010819)5.13662108
3Myokymia (HP:0002411)4.75091124
4Focal seizures (HP:0007359)4.69533558
5Epileptic encephalopathy (HP:0200134)4.69330980
6Absence seizures (HP:0002121)4.52184973
7Visual hallucinations (HP:0002367)4.43686402
8Progressive cerebellar ataxia (HP:0002073)4.13718496
9Febrile seizures (HP:0002373)4.00648345
10Dialeptic seizures (HP:0011146)3.96258943
11Pancreatic fibrosis (HP:0100732)3.37767958
12Pancreatic cysts (HP:0001737)3.36419188
13Generalized tonic-clonic seizures (HP:0002069)3.36308497
14Congenital stationary night blindness (HP:0007642)3.21843201
15Nephronophthisis (HP:0000090)3.18191617
16Gait imbalance (HP:0002141)3.09957312
17True hermaphroditism (HP:0010459)3.09584820
18Truncal ataxia (HP:0002078)3.05340967
19Broad-based gait (HP:0002136)3.04740543
20Chronic hepatic failure (HP:0100626)2.85052234
21Ankle clonus (HP:0011448)2.82057354
22Abnormality of the renal medulla (HP:0100957)2.78436760
23Excessive salivation (HP:0003781)2.72080412
24Drooling (HP:0002307)2.72080412
25Congenital primary aphakia (HP:0007707)2.66078416
26Epileptiform EEG discharges (HP:0011182)2.64980969
27Hyperventilation (HP:0002883)2.64520423
28Scanning speech (HP:0002168)2.59061657
29Gaze-evoked nystagmus (HP:0000640)2.58339986
30Nephrogenic diabetes insipidus (HP:0009806)2.56754866
31Impaired vibration sensation in the lower limbs (HP:0002166)2.55047983
32Aplasia/Hypoplasia of the tibia (HP:0005772)2.55000123
33EEG with generalized epileptiform discharges (HP:0011198)2.54597581
34Medial flaring of the eyebrow (HP:0010747)2.53906547
35Progressive inability to walk (HP:0002505)2.52607607
36Mutism (HP:0002300)2.51429004
37Impaired smooth pursuit (HP:0007772)2.50850626
38Genetic anticipation (HP:0003743)2.50511097
39Dysdiadochokinesis (HP:0002075)2.48057784
40Protruding tongue (HP:0010808)2.43001252
41Aplasia/Hypoplasia of the tongue (HP:0010295)2.40570768
42Absent speech (HP:0001344)2.40177059
43Depression (HP:0000716)2.39612504
44Volvulus (HP:0002580)2.38313105
45Hemiparesis (HP:0001269)2.36108324
46Abnormality of the corticospinal tract (HP:0002492)2.34969292
47Abnormality of the renal cortex (HP:0011035)2.34216490
48Postaxial foot polydactyly (HP:0001830)2.32917369
49Central scotoma (HP:0000603)2.32019590
50Anxiety (HP:0000739)2.31860276
51Hypsarrhythmia (HP:0002521)2.31206937
52Postaxial hand polydactyly (HP:0001162)2.31161356
53Abnormal hair whorl (HP:0010721)2.31112128
54Urinary bladder sphincter dysfunction (HP:0002839)2.30674843
55Abnormal eating behavior (HP:0100738)2.30652353
56Poor eye contact (HP:0000817)2.30324453
57Amblyopia (HP:0000646)2.30198358
58Dysmetria (HP:0001310)2.29671410
59Tubular atrophy (HP:0000092)2.28362361
60Tented upper lip vermilion (HP:0010804)2.28359718
61Cystic liver disease (HP:0006706)2.26715069
62Retinal dysplasia (HP:0007973)2.26593789
63Supranuclear gaze palsy (HP:0000605)2.26380072
64Diplopia (HP:0000651)2.25776908
65Abnormality of binocular vision (HP:0011514)2.25776908
66Limb dystonia (HP:0002451)2.24115926
67Inability to walk (HP:0002540)2.21869383
68Pheochromocytoma (HP:0002666)2.21455560
69Abnormal respiratory motile cilium physiology (HP:0012261)2.21355895
70Type II lissencephaly (HP:0007260)2.20312493
71Abnormality of macular pigmentation (HP:0008002)2.19913334
72Action tremor (HP:0002345)2.18625139
73Abnormality of ocular smooth pursuit (HP:0000617)2.18090159
74Supernumerary spleens (HP:0009799)2.17530769
75Abnormal ciliary motility (HP:0012262)2.16953161
76Severe visual impairment (HP:0001141)2.16584461
77Genital tract atresia (HP:0001827)2.15651484
78Spastic gait (HP:0002064)2.15099828
79Small hand (HP:0200055)2.13798164
80Polyphagia (HP:0002591)2.12586943
81Agitation (HP:0000713)2.11655578
82Intestinal atresia (HP:0011100)2.10468132
83Status epilepticus (HP:0002133)2.08099615
84Short foot (HP:0001773)2.07908883
85Impaired social interactions (HP:0000735)2.07857736
86Abnormal social behavior (HP:0012433)2.07857736
87Vaginal atresia (HP:0000148)2.07610073
88Patellar aplasia (HP:0006443)2.05945538
89Abnormal respiratory epithelium morphology (HP:0012253)2.04426821
90Abnormal respiratory motile cilium morphology (HP:0005938)2.04426821
91Pachygyria (HP:0001302)2.04385906
92Papilledema (HP:0001085)2.03931449
93Abnormality of the ischium (HP:0003174)2.03848908
94Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.01977928
95Short 4th metacarpal (HP:0010044)2.01977928
96Cerebellar dysplasia (HP:0007033)2.01929260
97Specific learning disability (HP:0001328)1.99352671
98Fetal akinesia sequence (HP:0001989)1.98672595
99Blue irides (HP:0000635)1.98184527
100Molar tooth sign on MRI (HP:0002419)1.97883948
101Abnormality of midbrain morphology (HP:0002418)1.97883948
102Postural instability (HP:0002172)1.96777136
103Astigmatism (HP:0000483)1.96529797
104Degeneration of the lateral corticospinal tracts (HP:0002314)1.95852094
105Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.95852094
106Poor coordination (HP:0002370)1.95194839
107Narrow forehead (HP:0000341)1.95159054
108Tubulointerstitial nephritis (HP:0001970)1.94080876
109Megalencephaly (HP:0001355)1.94003360
110Micropenis (HP:0000054)1.93461131
111Hypoplastic ischia (HP:0003175)1.92020763
112Bifid tongue (HP:0010297)1.91815938
113Preaxial hand polydactyly (HP:0001177)1.91262079
114Generalized myoclonic seizures (HP:0002123)1.91047083
115Urinary urgency (HP:0000012)1.90025332
116Oligodactyly (hands) (HP:0001180)1.89401392
117Chorioretinal atrophy (HP:0000533)1.89312167
118Abnormal rod and cone electroretinograms (HP:0008323)1.88783085
119Sclerocornea (HP:0000647)1.88652136
120Highly arched eyebrow (HP:0002553)1.87442702
121Abnormality of the labia minora (HP:0012880)1.87048521
122Occipital encephalocele (HP:0002085)1.86394159
123Neuroendocrine neoplasm (HP:0100634)1.86363429
124Fair hair (HP:0002286)1.85711981
125Lower limb muscle weakness (HP:0007340)1.85547680
126Poor suck (HP:0002033)1.85312907
127Termporal pattern (HP:0011008)1.85299274
128Insidious onset (HP:0003587)1.85299274
129Lissencephaly (HP:0001339)1.85210730
130Abnormality of the lower motor neuron (HP:0002366)1.84705740
131Delusions (HP:0000746)1.84085775
132Absent/shortened dynein arms (HP:0200106)1.83155199
133Dynein arm defect of respiratory motile cilia (HP:0012255)1.83155199
134Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.79946582
135Bradykinesia (HP:0002067)1.79904580
136Hyperthyroidism (HP:0000836)1.79878359
137Aplasia/Hypoplasia of the patella (HP:0006498)1.79398288
138Anencephaly (HP:0002323)1.79274154
139Widely spaced teeth (HP:0000687)1.79143755
140Congenital hepatic fibrosis (HP:0002612)1.79006669
141Hypothermia (HP:0002045)1.78860670
142Torticollis (HP:0000473)1.77819128
143Short tibia (HP:0005736)1.77727259
144Broad foot (HP:0001769)1.77674162
145Scotoma (HP:0000575)1.76871240
146Unsteady gait (HP:0002317)1.75956765
147Aplasia/Hypoplasia of the lens (HP:0008063)1.74756492
148Prominent nasal bridge (HP:0000426)1.72902078
149Amyotrophic lateral sclerosis (HP:0007354)1.69808130
150Dandy-Walker malformation (HP:0001305)1.69707182
151Astrocytoma (HP:0009592)1.68795983
152Abnormality of the astrocytes (HP:0100707)1.68795983
153Renal cortical cysts (HP:0000803)1.68585910
154Hypoplastic labia majora (HP:0000059)1.67200390
155Abnormality of the 4th metacarpal (HP:0010012)1.65677060
156Cutaneous finger syndactyly (HP:0010554)1.64556585
157Preaxial foot polydactyly (HP:0001841)1.64478270
158Absent frontal sinuses (HP:0002688)1.63977375
159Optic nerve hypoplasia (HP:0000609)1.63467028
160Tubulointerstitial abnormality (HP:0001969)1.62981427
161Rhinitis (HP:0012384)1.62562953
162Fibular hypoplasia (HP:0003038)1.59181933
163Aganglionic megacolon (HP:0002251)1.58822139
164Abnormality of the labia majora (HP:0012881)1.58040768
165Aplasia/Hypoplasia of the fibula (HP:0006492)1.56152140

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.73156639
2MARK14.23050253
3NTRK34.15533053
4MAP3K43.57108608
5MAP3K93.47167392
6BMPR1B3.39495567
7MAP2K73.38570493
8EPHA43.07653506
9MINK12.86240570
10CASK2.59776219
11NTRK22.40462843
12MKNK22.26823847
13MAP3K122.19968003
14PLK22.04301486
15PNCK1.99862438
16MAP2K41.93565031
17PAK61.88239342
18BRD41.87905906
19ACVR1B1.87139652
20LATS11.77700865
21NTRK11.77663088
22TRIM281.75599853
23MAPK131.71738880
24DAPK21.66483577
25LATS21.62623762
26SCYL21.60192297
27KSR11.59956718
28CDK191.58187964
29TNIK1.54695651
30ARAF1.52746893
31BRSK21.51042474
32TGFBR11.44202482
33MKNK11.41538401
34KSR21.41072346
35CDK51.40374440
36SIK21.37241879
37PRPF4B1.30389059
38DAPK11.29675326
39CSNK1A1L1.28276568
40PRKCG1.23559211
41CCNB11.23286019
42PRKD31.22470881
43NUAK11.22304338
44CAMKK11.20977653
45EPHA31.12838298
46MAP4K21.10957557
47GRK51.08260800
48CAMK2A1.07664703
49MAP3K131.06305073
50PAK31.05838240
51ERBB31.05073877
52NME11.04811401
53PHKG21.04564147
54PHKG11.04564147
55CSNK1G11.02975288
56SRPK11.00665180
57AKT31.00375329
58WEE11.00124511
59UHMK10.99543403
60CDK80.99393326
61ADRBK20.98577615
62DYRK1A0.98526607
63GRK10.98251407
64ZAK0.94594845
65STK30.93354683
66CAMKK20.92291690
67CAMK2B0.92122667
68CSNK1G20.91900504
69STK390.91111500
70CDK140.90287330
71CDK180.89999460
72CDK150.85858910
73FES0.84097871
74CAMK1G0.83982313
75FGFR20.81600410
76EPHB20.81482738
77STK380.79641926
78CAMK10.78876597
79BRAF0.78125543
80NEK10.77767142
81PIK3CA0.77722256
82NEK20.76880686
83CDK11A0.75538494
84SGK2230.74092598
85SGK4940.74092598
86MET0.73020188
87PLK40.71409302
88MARK20.71316533
89RIPK40.71179090
90RAF10.70410115
91PTK2B0.70191784
92RET0.70086847
93MAP3K60.69557906
94BRSK10.68435179
95PLK30.68418197
96WNK40.67833469
97PINK10.64890790
98DYRK20.64863913
99PRKCE0.64762078
100CAMK1D0.62410396
101SIK30.61773127
102RPS6KA40.60899014
103MAPK150.60555755
104CAMK2D0.60240910
105ATM0.58360991
106SGK20.57574261
107PLK10.56268654
108BMPR20.55810600
109OXSR10.54546819
110NEK90.54387354
111FER0.53326300
112INSRR0.53195399
113CDK30.51608212
114ROCK20.50963173
115ADRBK10.50477179
116MAP3K20.48896091
117BCR0.47652548
118DYRK30.47457105
119TAOK30.46812814
120CAMK2G0.46728286
121CSNK1G30.46530335
122ERBB40.46170843
123PKN10.46098965
124PDGFRB0.44613829
125EIF2AK30.43816645
126SGK10.43186235
127CSNK1D0.41700078
128STK110.41371824
129MAPK100.40630554
130RPS6KA30.39570658
131MAP2K10.38573738
132PRKAA10.38310454
133PRKCH0.37785999
134CDC42BPA0.37708640
135TSSK60.37515070
136CDC70.37459786
137BUB10.36040918
138PRKCB0.35336606
139ERBB20.35132309
140PRKCZ0.34989724
141DYRK1B0.34880771
142ATR0.34796629
143TYRO30.34549172
144STK38L0.34182690
145CDK90.34012660
146WNK30.33919991
147MELK0.33110989
148CHEK20.32728865
149WNK10.32653846
150MAPK90.32481841
151CSNK1E0.32219148
152FYN0.31964607
153PRKACA0.31561289
154FGR0.31177327
155PRKG10.29987043

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.45761610
2Synaptic vesicle cycle_Homo sapiens_hsa047213.67945221
3GABAergic synapse_Homo sapiens_hsa047273.08366443
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.96418229
5Olfactory transduction_Homo sapiens_hsa047402.76283648
6Morphine addiction_Homo sapiens_hsa050322.68816567
7Circadian entrainment_Homo sapiens_hsa047132.67258631
8Glutamatergic synapse_Homo sapiens_hsa047242.50695403
9Long-term potentiation_Homo sapiens_hsa047202.35836116
10Amphetamine addiction_Homo sapiens_hsa050312.25012774
11Dopaminergic synapse_Homo sapiens_hsa047282.19771316
12Taste transduction_Homo sapiens_hsa047422.03167824
13Fanconi anemia pathway_Homo sapiens_hsa034602.00630838
14Insulin secretion_Homo sapiens_hsa049111.99400141
15Salivary secretion_Homo sapiens_hsa049701.94404582
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.90241277
17Collecting duct acid secretion_Homo sapiens_hsa049661.87354213
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.87258942
19Long-term depression_Homo sapiens_hsa047301.86240261
20Serotonergic synapse_Homo sapiens_hsa047261.84837285
21Cholinergic synapse_Homo sapiens_hsa047251.80907629
22Renin secretion_Homo sapiens_hsa049241.78985839
23Hippo signaling pathway_Homo sapiens_hsa043901.71796400
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.70997355
25Phototransduction_Homo sapiens_hsa047441.68750729
26Cocaine addiction_Homo sapiens_hsa050301.62904619
27Basal transcription factors_Homo sapiens_hsa030221.60760611
28Non-homologous end-joining_Homo sapiens_hsa034501.59180153
29Butanoate metabolism_Homo sapiens_hsa006501.58445298
30Oxytocin signaling pathway_Homo sapiens_hsa049211.56520962
31Gastric acid secretion_Homo sapiens_hsa049711.52957485
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52440395
33Vibrio cholerae infection_Homo sapiens_hsa051101.50982016
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50137282
35Calcium signaling pathway_Homo sapiens_hsa040201.49216666
36Gap junction_Homo sapiens_hsa045401.38713233
37TGF-beta signaling pathway_Homo sapiens_hsa043501.37982104
38Protein export_Homo sapiens_hsa030601.36708522
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.35727411
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31027949
41Selenocompound metabolism_Homo sapiens_hsa004501.28502894
42Steroid biosynthesis_Homo sapiens_hsa001001.28429480
43Cardiac muscle contraction_Homo sapiens_hsa042601.25657412
44Axon guidance_Homo sapiens_hsa043601.24077213
45GnRH signaling pathway_Homo sapiens_hsa049121.23760487
46Basal cell carcinoma_Homo sapiens_hsa052171.22461402
47Oocyte meiosis_Homo sapiens_hsa041141.21627815
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16900659
49Homologous recombination_Homo sapiens_hsa034401.16276790
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16223687
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.16074898
52Lysine degradation_Homo sapiens_hsa003101.15735410
53cAMP signaling pathway_Homo sapiens_hsa040241.14994211
54Propanoate metabolism_Homo sapiens_hsa006401.14003273
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12896819
56Ether lipid metabolism_Homo sapiens_hsa005651.09804011
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03631591
58Estrogen signaling pathway_Homo sapiens_hsa049151.03511730
59Linoleic acid metabolism_Homo sapiens_hsa005911.03266915
60Nitrogen metabolism_Homo sapiens_hsa009100.99280361
61RNA degradation_Homo sapiens_hsa030180.99163382
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99107851
63Oxidative phosphorylation_Homo sapiens_hsa001900.97387480
64p53 signaling pathway_Homo sapiens_hsa041150.96908882
65mRNA surveillance pathway_Homo sapiens_hsa030150.95158521
66Melanogenesis_Homo sapiens_hsa049160.95030476
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94984439
68Fatty acid biosynthesis_Homo sapiens_hsa000610.94152981
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93587574
70ErbB signaling pathway_Homo sapiens_hsa040120.90854852
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.90009377
72Cell cycle_Homo sapiens_hsa041100.88446876
73Melanoma_Homo sapiens_hsa052180.88163798
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85957802
75Type II diabetes mellitus_Homo sapiens_hsa049300.84920778
76Glioma_Homo sapiens_hsa052140.84525911
77Alzheimers disease_Homo sapiens_hsa050100.83224312
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82426298
79Parkinsons disease_Homo sapiens_hsa050120.79510777
80MicroRNAs in cancer_Homo sapiens_hsa052060.76420144
81Alcoholism_Homo sapiens_hsa050340.76301085
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75713191
83Dilated cardiomyopathy_Homo sapiens_hsa054140.72813445
84RNA transport_Homo sapiens_hsa030130.72713468
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71925466
86Nucleotide excision repair_Homo sapiens_hsa034200.70006978
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69618378
88Circadian rhythm_Homo sapiens_hsa047100.68221187
89Thyroid hormone synthesis_Homo sapiens_hsa049180.68107313
90ABC transporters_Homo sapiens_hsa020100.65954432
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65566918
92ECM-receptor interaction_Homo sapiens_hsa045120.65477916
93Huntingtons disease_Homo sapiens_hsa050160.64812235
94Sphingolipid metabolism_Homo sapiens_hsa006000.63665094
95Adherens junction_Homo sapiens_hsa045200.63133111
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60080879
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57302953
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.55914095
99MAPK signaling pathway_Homo sapiens_hsa040100.54877168
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53818822
101Tight junction_Homo sapiens_hsa045300.53748279
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52962436
103Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52923673
104Pancreatic secretion_Homo sapiens_hsa049720.52720847
105Ovarian steroidogenesis_Homo sapiens_hsa049130.52148160
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51374042
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51061517
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50984487
109Dorso-ventral axis formation_Homo sapiens_hsa043200.50627025
110Glucagon signaling pathway_Homo sapiens_hsa049220.48350785
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48196614
112Pathways in cancer_Homo sapiens_hsa052000.47816680
113Type I diabetes mellitus_Homo sapiens_hsa049400.47788520
114Regulation of autophagy_Homo sapiens_hsa041400.47710522
115Ras signaling pathway_Homo sapiens_hsa040140.47063868
116Tryptophan metabolism_Homo sapiens_hsa003800.46593858
117Focal adhesion_Homo sapiens_hsa045100.46387207
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45102969
119Colorectal cancer_Homo sapiens_hsa052100.44363116
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44270431
121Wnt signaling pathway_Homo sapiens_hsa043100.43831535
122Inositol phosphate metabolism_Homo sapiens_hsa005620.43776874
123FoxO signaling pathway_Homo sapiens_hsa040680.43682794
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43093490
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.42445185
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39768550
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37475510
128Choline metabolism in cancer_Homo sapiens_hsa052310.37164702
129mTOR signaling pathway_Homo sapiens_hsa041500.37159244
130Rap1 signaling pathway_Homo sapiens_hsa040150.35868210
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.35109003
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34803977
133Renal cell carcinoma_Homo sapiens_hsa052110.34739603
134Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34279492
135Endometrial cancer_Homo sapiens_hsa052130.33392468
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33032127
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31423223
138Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30802304
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29997559
140Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27672736
141Insulin signaling pathway_Homo sapiens_hsa049100.26900194
142Hedgehog signaling pathway_Homo sapiens_hsa043400.26240302
143N-Glycan biosynthesis_Homo sapiens_hsa005100.24914802
144VEGF signaling pathway_Homo sapiens_hsa043700.24155909

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