PCOLCE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)8.37870461
2cartilage development involved in endochondral bone morphogenesis (GO:0060351)8.25011618
3keratan sulfate catabolic process (GO:0042340)7.88085906
4chondrocyte development (GO:0002063)7.77730272
5cartilage condensation (GO:0001502)7.04549689
6cell aggregation (GO:0098743)7.04549689
7triglyceride catabolic process (GO:0019433)7.02851335
8collagen fibril organization (GO:0030199)6.51163049
9regulation of sequestering of triglyceride (GO:0010889)6.44147893
10neutral lipid catabolic process (GO:0046461)6.31139020
11acylglycerol catabolic process (GO:0046464)6.31139020
12notochord development (GO:0030903)6.10466330
13positive regulation of endothelial cell differentiation (GO:0045603)5.85243142
14sensory perception of smell (GO:0007608)5.72617604
15fatty acid homeostasis (GO:0055089)5.50371091
16limb bud formation (GO:0060174)5.41740121
17endothelial cell morphogenesis (GO:0001886)5.22881060
18negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)4.81028298
19regulation of endothelial cell differentiation (GO:0045601)4.79343937
20NADH metabolic process (GO:0006734)4.65591243
21glycerolipid catabolic process (GO:0046503)4.44074517
22positive regulation of extracellular matrix organization (GO:1903055)4.25355727
23embryonic skeletal joint morphogenesis (GO:0060272)4.13378749
24plasma lipoprotein particle clearance (GO:0034381)4.10536441
25regulation of integrin-mediated signaling pathway (GO:2001044)4.09029411
26collagen catabolic process (GO:0030574)4.07378154
27blood vessel maturation (GO:0001955)4.07125690
28collagen metabolic process (GO:0032963)4.02503118
29positive regulation of chondrocyte differentiation (GO:0032332)4.02312972
30nucleotide-sugar biosynthetic process (GO:0009226)4.01733179
31regulation of cholesterol storage (GO:0010885)4.00106976
32cartilage development (GO:0051216)3.93843249
33regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.93363230
34lipid particle organization (GO:0034389)3.89686928
35protein heterotrimerization (GO:0070208)3.88516017
36cell migration involved in heart development (GO:0060973)3.86422670
37ovulation from ovarian follicle (GO:0001542)3.85684670
38biotin metabolic process (GO:0006768)3.85193941
39multicellular organismal macromolecule metabolic process (GO:0044259)3.84209575
40endochondral ossification (GO:0001958)3.81914358
41replacement ossification (GO:0036075)3.81914358
42response to BMP (GO:0071772)3.79652027
43cellular response to BMP stimulus (GO:0071773)3.79652027
44multicellular organismal catabolic process (GO:0044243)3.78760378
45protein retention in ER lumen (GO:0006621)3.77104959
46brown fat cell differentiation (GO:0050873)3.75044071
47lipid storage (GO:0019915)3.74681838
48negative regulation of smooth muscle cell migration (GO:0014912)3.72560874
49connective tissue development (GO:0061448)3.71955838
50retina vasculature morphogenesis in camera-type eye (GO:0061299)3.71795635
51wound healing, spreading of epidermal cells (GO:0035313)3.70436644
52white fat cell differentiation (GO:0050872)3.70232576
53sphingomyelin metabolic process (GO:0006684)3.69925508
54negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.69547698
55proteoglycan metabolic process (GO:0006029)3.64581535
56barbed-end actin filament capping (GO:0051016)3.64048773
57diacylglycerol metabolic process (GO:0046339)3.63314321
58multicellular organismal metabolic process (GO:0044236)3.62415758
59positive regulation of cartilage development (GO:0061036)3.61608166
60ethanol oxidation (GO:0006069)3.60149961
61keratan sulfate biosynthetic process (GO:0018146)3.58923997
62transcytosis (GO:0045056)3.58635969
63response to gravity (GO:0009629)3.57986119
64triglyceride biosynthetic process (GO:0019432)3.56082547
65maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.55140098
66response to dietary excess (GO:0002021)3.54882041
67chondroitin sulfate biosynthetic process (GO:0030206)3.52071866
68chondrocyte proliferation (GO:0035988)3.49064725
69peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.46629506
70iron ion import (GO:0097286)3.45187164
71polyol transport (GO:0015791)3.45035302
72endodermal cell differentiation (GO:0035987)3.44484174
73apoptotic cell clearance (GO:0043277)3.42044361
74extracellular matrix disassembly (GO:0022617)3.41780609
75regulation of cAMP-dependent protein kinase activity (GO:2000479)3.40979261
76sensory perception of chemical stimulus (GO:0007606)3.38682084
77regulation of metalloenzyme activity (GO:0048552)3.37811778
78neutral lipid biosynthetic process (GO:0046460)3.37385584
79acylglycerol biosynthetic process (GO:0046463)3.37385584
80extracellular fibril organization (GO:0043206)3.35467536
81cellular response to epinephrine stimulus (GO:0071872)3.32470099
82positive regulation of lipid storage (GO:0010884)3.32057118
83extracellular matrix assembly (GO:0085029)3.31409655
84fatty acid transmembrane transport (GO:1902001)3.31375908
85triglyceride metabolic process (GO:0006641)3.29710252
86cGMP-mediated signaling (GO:0019934)3.22023762
87bone trabecula formation (GO:0060346)3.21382557
88lymphangiogenesis (GO:0001946)3.19375434
89alpha-linolenic acid metabolic process (GO:0036109)3.18977511
90negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.16542518
91negative regulation of granulocyte differentiation (GO:0030853)3.16232316
92hypotonic response (GO:0006971)3.16113241
93short-term memory (GO:0007614)3.14237063
94extracellular matrix organization (GO:0030198)3.13962796
95extracellular structure organization (GO:0043062)3.13344455
96skeletal system development (GO:0001501)3.13262520
97endocardial cushion morphogenesis (GO:0003203)3.11417560
98regulation of chondrocyte differentiation (GO:0032330)3.10797600
99protein localization to cell surface (GO:0034394)3.09144762
100positive regulation of cholesterol efflux (GO:0010875)3.06383280
101oxaloacetate metabolic process (GO:0006107)3.06381373
102negative regulation of DNA biosynthetic process (GO:2000279)3.05395987
103primary alcohol metabolic process (GO:0034308)3.04877060
104positive regulation of glucose import (GO:0046326)3.04141741
105negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.03684569
106negative regulation of macrophage differentiation (GO:0045650)3.03341097
107negative regulation of endothelial cell proliferation (GO:0001937)3.03148687
108myelin assembly (GO:0032288)3.02564099
109artery development (GO:0060840)3.01584962
110acylglycerol metabolic process (GO:0006639)3.01541646
111tricarboxylic acid metabolic process (GO:0072350)3.01427071
112daunorubicin metabolic process (GO:0044597)3.01302617
113polyketide metabolic process (GO:0030638)3.01302617
114doxorubicin metabolic process (GO:0044598)3.01302617
115CDP-diacylglycerol metabolic process (GO:0046341)2.97807217
116positive regulation of cellular response to insulin stimulus (GO:1900078)2.95274582
117neutral lipid metabolic process (GO:0006638)2.95170546
118negative regulation of cartilage development (GO:0061037)2.94196140
119keratan sulfate metabolic process (GO:0042339)2.93864585
120CDP-diacylglycerol biosynthetic process (GO:0016024)2.93523985
121positive regulation of glomerulus development (GO:0090193)2.92556532
122regulation of gonadotropin secretion (GO:0032276)2.92243941
123peptidyl-proline hydroxylation (GO:0019511)2.91995819
124chemical homeostasis within a tissue (GO:0048875)2.91257817
125negative regulation of heart growth (GO:0061117)2.89366818
126negative regulation of cardiac muscle tissue growth (GO:0055022)2.89366818
127cyclooxygenase pathway (GO:0019371)2.89294655
128negative regulation of chondrocyte differentiation (GO:0032331)2.89134447
129regulation of macrophage derived foam cell differentiation (GO:0010743)2.88317862
130response to epinephrine (GO:0071871)2.87363782
131membrane raft organization (GO:0031579)2.86444830
132regulation of cartilage development (GO:0061035)2.85986509
133positive regulation of triglyceride lipase activity (GO:0061365)2.85260020
134positive regulation of lipoprotein lipase activity (GO:0051006)2.85260020
135skin morphogenesis (GO:0043589)2.84175329
136phagocytosis, recognition (GO:0006910)2.84121114
137lymph vessel development (GO:0001945)2.82029381
138negative regulation of smooth muscle cell differentiation (GO:0051151)2.81101691
139surfactant homeostasis (GO:0043129)2.79614935
140negative regulation of homotypic cell-cell adhesion (GO:0034111)2.79548171
141aminoglycan biosynthetic process (GO:0006023)2.79243884
142vascular endothelial growth factor signaling pathway (GO:0038084)2.79135298
143glycosaminoglycan biosynthetic process (GO:0006024)2.79130561
144sequestering of extracellular ligand from receptor (GO:0035581)2.78633636
145negative regulation of smooth muscle cell proliferation (GO:0048662)2.78343675
146regulation of glycogen (starch) synthase activity (GO:2000465)2.78080043
147negative regulation of metanephros development (GO:0072217)2.77225874
148positive regulation of vascular permeability (GO:0043117)2.75551475
149phosphatidic acid metabolic process (GO:0046473)2.74811574
150phosphatidic acid biosynthetic process (GO:0006654)2.74811574
151endocrine hormone secretion (GO:0060986)2.74291625
152ethanol metabolic process (GO:0006067)2.73655227
153aminoglycoside antibiotic metabolic process (GO:0030647)2.73080232
154cellular response to vitamin (GO:0071295)2.72733811
155negative regulation of protein autophosphorylation (GO:0031953)2.72321532
156positive regulation of endothelial cell apoptotic process (GO:2000353)2.72080684
157lung vasculature development (GO:0060426)2.71866298
158thioester biosynthetic process (GO:0035384)2.71755218
159acyl-CoA biosynthetic process (GO:0071616)2.71755218
160regulation of lipoprotein metabolic process (GO:0050746)2.71510678
161acylglycerol homeostasis (GO:0055090)2.70695872
162triglyceride homeostasis (GO:0070328)2.70695872
163mesenchyme morphogenesis (GO:0072132)2.70601715
164regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393)2.68858519
165response to phenylpropanoid (GO:0080184)2.68845795
166central nervous system myelination (GO:0022010)2.68348927
167axon ensheathment in central nervous system (GO:0032291)2.68348927
168positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.68243287
169regulation of plasminogen activation (GO:0010755)2.67629327
170dermatan sulfate biosynthetic process (GO:0030208)2.66887756
171stress fiber assembly (GO:0043149)2.66646028
172fatty-acyl-CoA biosynthetic process (GO:0046949)2.66364605
173carnitine shuttle (GO:0006853)2.65990164
174fibril organization (GO:0097435)2.65092091
175glycosaminoglycan catabolic process (GO:0006027)2.65006330
176positive regulation of osteoblast proliferation (GO:0033690)2.64281116
177chondrocyte differentiation (GO:0002062)2.63586886
178wound healing, spreading of cells (GO:0044319)2.63531401
179hyperosmotic salinity response (GO:0042538)2.63298525
180prostaglandin biosynthetic process (GO:0001516)2.61824647
181prostanoid biosynthetic process (GO:0046457)2.61824647
182regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.60259068
183UDP-N-acetylglucosamine metabolic process (GO:0006047)2.58648052
184positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.55665754
185regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.52889559
186regulation of extracellular matrix disassembly (GO:0010715)2.51338261
187cardiac epithelial to mesenchymal transition (GO:0060317)2.47043717

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human7.94954427
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.32530468
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.80292697
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.62522108
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.47078526
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.08383413
7GATA1_22025678_ChIP-Seq_K562_Human2.87746223
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.68074611
9CLOCK_20551151_ChIP-Seq_293T_Human2.60055676
10NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.57768515
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.46023759
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.45924816
13RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.44304739
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.42275730
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.40339853
16CJUN_26792858_Chip-Seq_BT549_Human2.40095030
17TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.39827507
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.36281203
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.36281203
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.36281203
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.30866226
22SMAD_19615063_ChIP-ChIP_OVARY_Human2.30659879
23WT1_19549856_ChIP-ChIP_CCG9911_Human2.09079790
24AR_21572438_ChIP-Seq_LNCaP_Human2.05301516
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.02364294
26PPARA_22158963_ChIP-Seq_LIVER_Mouse2.01628273
27LXR_22158963_ChIP-Seq_LIVER_Mouse1.99989459
28PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.88009910
29PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.87719136
30ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.86247396
31CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.84187252
32CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.76500303
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.72734855
34* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.64712931
35* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.63544385
36SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.62891359
37FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.62519566
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.61197886
39SALL4_18804426_ChIP-ChIP_XEN_Mouse1.61038061
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.60393925
41TP53_18474530_ChIP-ChIP_U2OS_Human1.59753605
42NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.59005898
43ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.58213994
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57706388
45SOX2_20726797_ChIP-Seq_SW620_Human1.55744287
46TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55291450
47* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54636821
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.52840310
49NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.49614451
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48734832
51ZNF263_19887448_ChIP-Seq_K562_Human1.48719076
52SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.48267413
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46984542
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.44044756
55TBX20_22080862_ChIP-Seq_HEART_Mouse1.43643040
56TBX20_22328084_ChIP-Seq_HEART_Mouse1.43643040
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.43145660
58BRD4_25478319_ChIP-Seq_HGPS_Human1.41856742
59NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40473550
60NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40473550
61* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.39738678
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38501511
63NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.36649402
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36230773
65NFIB_24661679_ChIP-Seq_LUNG_Mouse1.33654754
66GATA3_24758297_ChIP-Seq_MCF-7_Human1.29510325
67ESR1_20079471_ChIP-ChIP_T-47D_Human1.29480058
68POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23367575
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21776155
70* EP300_21415370_ChIP-Seq_HL-1_Mouse1.21328869
71SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.19985439
72SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.19985439
73AR_21909140_ChIP-Seq_LNCAP_Human1.17316977
74P63_26484246_Chip-Seq_KERATINOCYTES_Human1.16519375
75P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15759711
76SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.15714615
77HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15369255
78ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14246064
79TCF3_18692474_ChIP-Seq_MEFs_Mouse1.13681888
80NANOG_18692474_ChIP-Seq_MEFs_Mouse1.13614139
81SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12835808
82SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10634676
83SMC1_22415368_ChIP-Seq_MEFs_Mouse1.10226981
84EZH2_18974828_ChIP-Seq_MESCs_Mouse1.08591904
85RNF2_18974828_ChIP-Seq_MESCs_Mouse1.08591904
86TP53_20018659_ChIP-ChIP_R1E_Mouse1.08063989
87TCF3_18692474_ChIP-Seq_MESCs_Mouse1.07624635
88* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06267495
89EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06127980
90MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05880699
91* CSB_26484114_Chip-Seq_FIBROBLAST_Human1.05876577
92ELK1_22589737_ChIP-Seq_MCF10A_Human1.02864986
93* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.01742525
94RAD21_21589869_ChIP-Seq_MESCs_Mouse1.01263154
95SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00912745
96TP53_22127205_ChIP-Seq_IMR90_Human1.00817058
97RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00539903
98MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.00027612
99SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99132697
100* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98741282
101PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98312662
102TP53_23651856_ChIP-Seq_MEFs_Mouse0.98207488
103SA1_22415368_ChIP-Seq_MEFs_Mouse0.97716694
104NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97243060
105ATF3_27146783_Chip-Seq_COLON_Human0.96651182
106* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95355979
107PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94927495
108NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93477767
109* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.92728919
110RACK7_27058665_Chip-Seq_MCF-7_Human0.92432942
111STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92422522
112CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92383934
113SOX2_18692474_ChIP-Seq_MEFs_Mouse0.92256744
114TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92009416
115UBF1/2_26484160_Chip-Seq_HMECs_Human0.91659033
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91402117
117* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90816688
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89542088
119KDM2B_26808549_Chip-Seq_K562_Human0.88093309
120SMC3_22415368_ChIP-Seq_MEFs_Mouse0.88044672
121UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.88021088
122EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.87983916
123FOXO3_23340844_ChIP-Seq_DLD1_Human0.87420968
124TP63_23658742_ChIP-Seq_EP156T_Human0.87350438
125SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.85491375
126ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.84992161
127KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.84957520
128PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.84164661
129SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83703289
130AHR_22903824_ChIP-Seq_MCF-7_Human0.83314832
131SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.83220876
132EOMES_21245162_ChIP-Seq_HESCs_Human0.83208120
133HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82881613
134KLF5_25053715_ChIP-Seq_YYC3_Human0.81472541
135TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.81329250
136FOXM1_26456572_ChIP-Seq_MCF-7_Human0.81183509
137PIAS1_25552417_ChIP-Seq_VCAP_Human0.81133410
138MTF2_20144788_ChIP-Seq_MESCs_Mouse0.80540470
139OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80409236
140KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.79471917
141STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.77716415
142TET1_21490601_ChIP-Seq_MESCs_Mouse0.76932062
143EGR1_23403033_ChIP-Seq_LIVER_Mouse0.75014582
144SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.74074853
145ERG_21242973_ChIP-ChIP_JURKAT_Human0.70620130

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose6.10417236
2MP0008438_abnormal_cutaneous_collagen5.36345135
3MP0005503_abnormal_tendon_morphology4.82844611
4MP0005275_abnormal_skin_tensile4.01512259
5MP0005666_abnormal_adipose_tissue3.93276147
6MP0004134_abnormal_chest_morphology3.55671278
7MP0001958_emphysema3.44802498
8MP0002933_joint_inflammation3.42240996
9MP0002282_abnormal_trachea_morphology3.20881333
10MP0004130_abnormal_muscle_cell3.17193263
11MP0005375_adipose_tissue_phenotype2.95024468
12MP0003705_abnormal_hypodermis_morpholog2.88815046
13MP0004185_abnormal_adipocyte_glucose2.87339210
14MP0002971_abnormal_brown_adipose2.80956836
15MP0009250_abnormal_appendicular_skeleto2.78181339
16MP0001542_abnormal_bone_strength2.66048060
17MP0000163_abnormal_cartilage_morphology2.64920727
18MP0005508_abnormal_skeleton_morphology2.54359832
19MP0010030_abnormal_orbit_morphology2.48708737
20MP0001984_abnormal_olfaction2.46494297
21MP0003279_aneurysm2.34684903
22MP0006138_congestive_heart_failure2.30245541
23MP0008004_abnormal_stomach_pH2.23612034
24MP0004272_abnormal_basement_membrane2.11809968
25MP0000762_abnormal_tongue_morphology2.11717635
26MP0002115_abnormal_skeleton_extremities2.05159943
27MP0003646_muscle_fatigue2.03379243
28MP0010368_abnormal_lymphatic_system2.02698873
29MP0001299_abnormal_eye_distance/1.98103562
30MP0009115_abnormal_fat_cell1.92508824
31MP0002896_abnormal_bone_mineralization1.88314558
32MP0003806_abnormal_nucleotide_metabolis1.85261758
33MP0003011_delayed_dark_adaptation1.84156442
34MP0003566_abnormal_cell_adhesion1.81153306
35MP0003283_abnormal_digestive_organ1.80798854
36MP0009384_cardiac_valve_regurgitation1.79266284
37MP0002113_abnormal_skeleton_development1.75741431
38MP0001661_extended_life_span1.73250334
39MP0002108_abnormal_muscle_morphology1.72774979
40MP0002295_abnormal_pulmonary_circulatio1.69429201
41MP0000751_myopathy1.69291473
42MP0003959_abnormal_lean_body1.67125339
43MP0005390_skeleton_phenotype1.66887988
44MP0002970_abnormal_white_adipose1.65433796
45MP0003828_pulmonary_edema1.63220387
46MP0002877_abnormal_melanocyte_morpholog1.62791626
47MP0005623_abnormal_meninges_morphology1.56839457
48MP0000013_abnormal_adipose_tissue1.54616400
49MP0002233_abnormal_nose_morphology1.53711142
50MP0005334_abnormal_fat_pad1.49211105
51MP0003950_abnormal_plasma_membrane1.48867209
52MP0010329_abnormal_lipoprotein_level1.48742596
53MP0001879_abnormal_lymphatic_vessel1.48551218
54MP0003755_abnormal_palate_morphology1.47322920
55MP0001544_abnormal_cardiovascular_syste1.43212502
56MP0005385_cardiovascular_system_phenoty1.43212502
57MP0005023_abnormal_wound_healing1.42677329
58MP0004087_abnormal_muscle_fiber1.37543701
59MP0000343_altered_response_to1.36229014
60MP0002109_abnormal_limb_morphology1.36136806
61MP0000049_abnormal_middle_ear1.29081645
62MP0001533_abnormal_skeleton_physiology1.26822040
63MP0004215_abnormal_myocardial_fiber1.24724181
64MP0003868_abnormal_feces_composition1.23515910
65MP0002060_abnormal_skin_morphology1.22850753
66MP0008789_abnormal_olfactory_epithelium1.22529794
67MP0004036_abnormal_muscle_relaxation1.21948835
68MP0002138_abnormal_hepatobiliary_system1.21162633
69MP0004782_abnormal_surfactant_physiolog1.20047570
70MP0002876_abnormal_thyroid_physiology1.17922291
71MP0003091_abnormal_cell_migration1.15844117
72MP0002116_abnormal_craniofacial_bone1.15461525
73MP0002972_abnormal_cardiac_muscle1.13168958
74MP0000432_abnormal_head_morphology1.12741236
75MP0003795_abnormal_bone_structure1.11234680
76MP0005535_abnormal_body_temperature1.10254102
77MP0002249_abnormal_larynx_morphology1.09965514
78MP0009780_abnormal_chondrocyte_physiolo1.08137789
79MP0003937_abnormal_limbs/digits/tail_de1.04201951
80MP0002089_abnormal_postnatal_growth/wei1.04114146
81MP0005330_cardiomyopathy1.03912939
82MP0002118_abnormal_lipid_homeostasis1.03873242
83MP0000749_muscle_degeneration1.03084765
84MP0001270_distended_abdomen1.02838730
85MP0002111_abnormal_tail_morphology1.01951565
86MP0003935_abnormal_craniofacial_develop1.00701676
87MP0002653_abnormal_ependyma_morphology0.99488231
88MP0005452_abnormal_adipose_tissue0.97190089
89MP0003191_abnormal_cellular_cholesterol0.96857756
90MP0005164_abnormal_response_to0.96344967
91MP0010630_abnormal_cardiac_muscle0.95486125
92MP0002932_abnormal_joint_morphology0.94932246
93MP0003941_abnormal_skin_development0.94170446
94MP0005367_renal/urinary_system_phenotyp0.94060872
95MP0000516_abnormal_urinary_system0.94060872
96MP0004084_abnormal_cardiac_muscle0.93685195
97MP0000747_muscle_weakness0.92645377
98MP0000750_abnormal_muscle_regeneration0.92440526
99MP0002133_abnormal_respiratory_system0.91462454
100MP0005388_respiratory_system_phenotype0.91462454
101MP0004133_heterotaxia0.91162724
102MP0004484_altered_response_of0.89630924
103MP0000767_abnormal_smooth_muscle0.89132346
104MP0005620_abnormal_muscle_contractility0.88952075
105MP0005171_absent_coat_pigmentation0.88912051
106MP0003385_abnormal_body_wall0.86271870
107MP0003942_abnormal_urinary_system0.83525616
108MP0002114_abnormal_axial_skeleton0.82156030
109MP0005595_abnormal_vascular_smooth0.81850648
110MP0005165_increased_susceptibility_to0.81784151
111MP0001177_atelectasis0.81736477
112MP0000566_synostosis0.80168480
113MP0005448_abnormal_energy_balance0.80039952
114MP0002909_abnormal_adrenal_gland0.79834794
115MP0003123_paternal_imprinting0.79333821
116MP0000534_abnormal_ureter_morphology0.78425332
117MP0005647_abnormal_sex_gland0.77753150
118MP0003690_abnormal_glial_cell0.76991513
119MP0005499_abnormal_olfactory_system0.76149492
120MP0005394_taste/olfaction_phenotype0.76149492
121MP0002269_muscular_atrophy0.74396280
122MP0005257_abnormal_intraocular_pressure0.74249495
123MP0004233_abnormal_muscle_weight0.73358143
124MP0002332_abnormal_exercise_endurance0.72531172
125MP0000733_abnormal_muscle_development0.70222793
126MP0001175_abnormal_lung_morphology0.69754513
127MP0002998_abnormal_bone_remodeling0.69570850
128MP0000249_abnormal_blood_vessel0.69379173
129MP0005365_abnormal_bile_salt0.68965088
130MP0008775_abnormal_heart_ventricle0.68087129
131MP0003137_abnormal_impulse_conducting0.68030737
132MP0006036_abnormal_mitochondrial_physio0.66286862
133MP0001881_abnormal_mammary_gland0.64345875
134MP0004858_abnormal_nervous_system0.63506839
135MP0000003_abnormal_adipose_tissue0.63444859
136MP0002168_other_aberrant_phenotype0.63053558
137MP0010352_gastrointestinal_tract_polyps0.62484693
138MP0002638_abnormal_pupillary_reflex0.61916868
139MP0003724_increased_susceptibility_to0.61525142
140MP0001614_abnormal_blood_vessel0.60746283
141MP0003186_abnormal_redox_activity0.60707392
142MP0001293_anophthalmia0.60090016
143MP0000759_abnormal_skeletal_muscle0.59430994
144MP0005584_abnormal_enzyme/coenzyme_acti0.58415210
145MP0003948_abnormal_gas_homeostasis0.57766595
146MP0005369_muscle_phenotype0.57562808
147MP0001243_abnormal_dermal_layer0.57450607
148MP0002128_abnormal_blood_circulation0.55501474

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)8.25131080
2Irregular epiphyses (HP:0010582)8.10443242
3Vitreoretinal degeneration (HP:0000655)6.68110107
4Hypoplastic ischia (HP:0003175)5.81152866
5Small epiphyses (HP:0010585)5.55356671
6Cupped ribs (HP:0000887)5.39332982
7Abnormality of the ischium (HP:0003174)5.17014110
8Abnormal tarsal ossification (HP:0008369)5.02355366
9Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.87728198
10Flat capital femoral epiphysis (HP:0003370)4.87364445
11Genu varum (HP:0002970)4.67676758
12Flat acetabular roof (HP:0003180)4.52664678
13Oligomenorrhea (HP:0000876)4.48190393
14Delayed epiphyseal ossification (HP:0002663)4.23792226
15Acanthosis nigricans (HP:0000956)4.15380744
16Aortic aneurysm (HP:0004942)4.15309207
17Vertebral compression fractures (HP:0002953)4.14303140
18Neonatal short-limb short stature (HP:0008921)4.13914533
19Increased variability in muscle fiber diameter (HP:0003557)4.05007896
20Abnormality of femoral epiphyses (HP:0006499)4.01610238
21Abnormality involving the epiphyses of the lower limbs (HP:0006500)4.01610238
22Osteoarthritis (HP:0002758)3.83501209
23Flattened epiphyses (HP:0003071)3.80390812
24Absent epiphyses (HP:0010577)3.77102765
25Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.77102765
26Mild short stature (HP:0003502)3.76046555
27Hypertriglyceridemia (HP:0002155)3.75186981
28Metaphyseal cupping (HP:0003021)3.66452832
29Abnormal foot bone ossification (HP:0010675)3.62900479
30Arthropathy (HP:0003040)3.59374567
31Abnormality of the epiphysis of the femoral head (HP:0010574)3.58480234
32Abnormality of the vertebral endplates (HP:0005106)3.58175953
33Complement deficiency (HP:0004431)3.56182071
34Shallow orbits (HP:0000586)3.53272838
35Broad metatarsal (HP:0001783)3.45744975
36Abnormality of skeletal muscle fiber size (HP:0012084)3.44686391
37Abnormality of the femoral head (HP:0003368)3.33593246
38Vascular tortuosity (HP:0004948)3.28188660
39Coxa vara (HP:0002812)3.27432040
40Premature rupture of membranes (HP:0001788)3.26547533
41Soft skin (HP:0000977)3.25893949
42Cervical subluxation (HP:0003308)3.25785950
43Abnormality of complement system (HP:0005339)3.24430255
44Short femoral neck (HP:0100864)3.21663100
45Irregular vertebral endplates (HP:0003301)3.18617845
46Myocardial infarction (HP:0001658)3.18235534
47Aortic dissection (HP:0002647)3.08025359
48Reduced subcutaneous adipose tissue (HP:0003758)3.06993072
49Lipoatrophy (HP:0100578)3.05856563
50Pulmonary artery stenosis (HP:0004415)2.97867314
51Beaking of vertebral bodies (HP:0004568)2.96464790
52Protrusio acetabuli (HP:0003179)2.94771036
53Platyspondyly (HP:0000926)2.93452171
54Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.91347823
55Abnormality of the proximal phalanges of the hand (HP:0009834)2.86391518
56Mitral stenosis (HP:0001718)2.85673753
57Wrist flexion contracture (HP:0001239)2.82553322
58Abnormality of the pubic bones (HP:0003172)2.80353094
59Metaphyseal irregularity (HP:0003025)2.79389737
60Abnormal vertebral ossification (HP:0100569)2.78527803
61Abnormality of the phalanges of the 2nd finger (HP:0009541)2.77092075
62Ectopia lentis (HP:0001083)2.76103682
63Systemic lupus erythematosus (HP:0002725)2.73319291
64Carpal bone hypoplasia (HP:0001498)2.73183257
65Metaphyseal dysplasia (HP:0100255)2.71000507
66Bladder diverticulum (HP:0000015)2.68361480
67Abnormality of carpal bone ossification (HP:0006257)2.65843331
68Insulin resistance (HP:0000855)2.65281368
69Skin nodule (HP:0200036)2.64369556
70Overgrowth (HP:0001548)2.63702860
71Thoracolumbar scoliosis (HP:0002944)2.63364110
72Barrel-shaped chest (HP:0001552)2.62496164
73Type 1 muscle fiber predominance (HP:0003803)2.62037029
74Back pain (HP:0003418)2.60339786
75Stillbirth (HP:0003826)2.59231341
76Arterial tortuosity (HP:0005116)2.58796408
77Protuberant abdomen (HP:0001538)2.58447452
78Vertebral clefting (HP:0008428)2.55437180
79Broad ribs (HP:0000885)2.53076312
80Ulnar bowing (HP:0003031)2.52581792
81Hypoplasia of the odontoid process (HP:0003311)2.50452587
82Limited elbow extension (HP:0001377)2.50184143
83Limited hip movement (HP:0008800)2.49488715
84Waddling gait (HP:0002515)2.47983208
85Aortic valve stenosis (HP:0001650)2.47922915
86Biconcave vertebral bodies (HP:0004586)2.46644557
87Dilatation of the ascending aorta (HP:0005111)2.45688784
88Ovoid vertebral bodies (HP:0003300)2.44904836
89Thin ribs (HP:0000883)2.44437472
90Striae distensae (HP:0001065)2.43195547
91Osteolytic defects of the phalanges of the hand (HP:0009771)2.40269541
92Osteolytic defects of the hand bones (HP:0009699)2.40269541
93Cerebral aneurysm (HP:0004944)2.39856295
94Abnormality of incisor morphology (HP:0011063)2.39143346
95Aplasia/hypoplasia of the femur (HP:0005613)2.38471538
96Mitral valve prolapse (HP:0001634)2.37565671
97Long clavicles (HP:0000890)2.37150393
98Hip contracture (HP:0003273)2.35432689
99Spinal cord compression (HP:0002176)2.35428828
100Blue sclerae (HP:0000592)2.30235261
101Abnormality of the acetabulum (HP:0003170)2.28775843
102Absent frontal sinuses (HP:0002688)2.28493874
103Round ear (HP:0100830)2.27731022
104Increased serum pyruvate (HP:0003542)2.25075485
105Hyperlipoproteinemia (HP:0010980)2.22576005
106Patent foramen ovale (HP:0001655)2.22553304
107Asymmetric septal hypertrophy (HP:0001670)2.22099643
108Glossoptosis (HP:0000162)2.20455876
109Coronal craniosynostosis (HP:0004440)2.20452164
110Mesomelia (HP:0003027)2.20174073
111Abnormality of the vitreous humor (HP:0004327)2.19638885
112Hypoalphalipoproteinemia (HP:0003233)2.18723766
113Abnormality of the odontoid process (HP:0003310)2.18516461
114Enlarged epiphyses (HP:0010580)2.18325015
115Difficulty running (HP:0009046)2.17160983
116Wormian bones (HP:0002645)2.15739745
117Mitral regurgitation (HP:0001653)2.14557205
118Genu recurvatum (HP:0002816)2.12999784
119Lumbar hyperlordosis (HP:0002938)2.12033459
120Joint stiffness (HP:0001387)2.11795542
121Hypercortisolism (HP:0001578)2.09067859
122Neck muscle weakness (HP:0000467)2.08401329
123Vertebral hypoplasia (HP:0008417)2.07974064
124Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.07974064
125Atrioventricular block (HP:0001678)2.07836693
126Abnormal ossification of hand bones (HP:0005921)2.07552370
127Axonal loss (HP:0003447)2.07239229
128Exostoses (HP:0100777)2.06159717
129Micromelia (HP:0002983)2.04967906
130Polycythemia (HP:0001901)2.04924643
131Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.04909978
132Joint laxity (HP:0001388)2.04847552
133Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.03937872
134Cardiovascular calcification (HP:0011915)2.03587908
135Infantile muscular hypotonia (HP:0008947)2.03056489
136Fibular hypoplasia (HP:0003038)2.02665328
137Abnormal hand bone ossification (HP:0010660)2.02272456
138Mildly elevated creatine phosphokinase (HP:0008180)2.02172857
139Nausea (HP:0002018)2.01482979
140Abnormality of the 2nd finger (HP:0004100)2.01001672
141Hyporeflexia of lower limbs (HP:0002600)2.00915563
142Distal lower limb muscle weakness (HP:0009053)2.00775076
143Muscle fiber splitting (HP:0003555)2.00435682
144Broad phalanx (HP:0006009)1.99751758
145Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.99684218
146Abnormality of glycolysis (HP:0004366)1.99280566
147Aneurysm (HP:0002617)1.98652047
148Radial bowing (HP:0002986)1.98451304
149Nuclear cataract (HP:0100018)1.98397619
150Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.96435257
151Follicular hyperkeratosis (HP:0007502)1.95582599
152Broad long bones (HP:0005622)1.95582440
153Spinal cord lesions (HP:0100561)1.95134503
154Syringomyelia (HP:0003396)1.95134503
155Abnormality of the distal phalanges of the toes (HP:0010182)1.93758820
156Hypercholesterolemia (HP:0003124)1.93501867
157Hypoplasia of the iris (HP:0007676)1.93178132
158Spinal rigidity (HP:0003306)1.92832316
159Insulin-resistant diabetes mellitus (HP:0000831)1.91953048
160Abnormality of dentin (HP:0010299)1.91904239
161Ankle contracture (HP:0006466)1.90062017
162Abnormality of alanine metabolism (HP:0010916)1.89680741
163Hyperalaninemia (HP:0003348)1.89680741
164Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89680741
165Xanthomatosis (HP:0000991)1.87347561
166Hyperextensible skin (HP:0000974)1.87085977
167Disproportionate short-trunk short stature (HP:0003521)1.87011684
168Severe Myopia (HP:0011003)1.86011100
169Short nail (HP:0001799)1.85765909
170Ventricular tachycardia (HP:0004756)1.85363063
171Hemorrhage of the eye (HP:0011885)1.85145443
172Venous abnormality (HP:0002624)1.84874851
173Dilated cardiomyopathy (HP:0001644)1.84385673
174Delayed cranial suture closure (HP:0000270)1.83032835
175Abnormal delivery (HP:0001787)1.82888074
176Sudden death (HP:0001699)1.81899325
177Abnormal atrioventricular conduction (HP:0005150)1.79902324
178Increased connective tissue (HP:0009025)1.79767577
179Subcapsular cataract (HP:0000523)1.79656675
180Short middle phalanx of finger (HP:0005819)1.79216952
181Hypoplastic scapulae (HP:0000882)1.79211966
182Elbow flexion contracture (HP:0002987)1.78970284
183Atrial fibrillation (HP:0005110)1.78779139

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR26.09679090
2MAP3K34.71883046
3MYLK4.37620097
4STK38L4.05418002
5ERBB33.89155946
6TIE13.31582451
7STK243.27655451
8PRKG22.44036680
9TGFBR22.33198686
10PHKG22.29945191
11PHKG12.29945191
12TRPM72.22544770
13ARAF2.08128317
14ERN12.01329869
15PRKAA21.98036188
16ABL21.91083542
17TTN1.85170554
18MAP3K61.82319061
19MAPKAPK31.67455778
20PLK21.66746428
21MST41.63206281
22STK391.55596603
23MET1.55578708
24TRIB31.54145644
25LIMK11.50621788
26LATS21.48558671
27PIM21.47371599
28EPHA21.45917928
29FER1.45036205
30CAMK11.42923021
31EEF2K1.37695436
32LATS11.34285752
33PDK21.32900181
34DMPK1.30787927
35PAK31.23884780
36EPHB21.23838102
37MAPK151.15022074
38MOS1.13246518
39ERBB41.12610223
40CAMK1G1.11578552
41STK31.11551836
42CDK91.10273117
43EIF2AK31.09645408
44PRPF4B1.08961359
45NME11.08226277
46CAMK2D1.06363413
47NME21.03925304
48TESK11.03082290
49PRKAA10.99568103
50ILK0.97037263
51MAPK40.95469041
52PDGFRB0.95088160
53STK100.87085621
54BRAF0.86972302
55GRK10.86430879
56MTOR0.85293622
57GSK3A0.82582856
58BCR0.81807872
59ICK0.79055997
60PRKD30.77917028
61PDPK10.77116446
62PKN20.76600625
63DAPK30.75945357
64RPS6KA40.74285736
65PLK40.72757017
66PKN10.72569376
67ROCK10.72394152
68MAP2K10.71139987
69AKT30.71110945
70AKT20.70859627
71MAP3K130.70006222
72CAMK2B0.69493236
73ROCK20.68992781
74PRKACG0.67908234
75CSK0.67149588
76TTK0.66776026
77CDK40.64883011
78BMPR20.64573074
79PRKD10.63071706
80CDC42BPA0.62462023
81EPHB10.62409179
82GRK50.62367937
83PDGFRA0.62164812
84DYRK1A0.60776889
85PAK20.58881626
86STK40.58559010
87MAP3K110.56511609
88PTK2B0.55023338
89CAMK2G0.51923737
90LMTK20.50734245
91STK160.50392761
92NUAK10.49902365
93MAPK120.49816951
94PAK40.49763561
95PRKD20.47211507
96KSR20.46009173
97LRRK20.44746577
98OXSR10.43841980
99MAP2K30.42751646
100PINK10.42386348
101MAPKAPK50.41759948
102FLT30.41584744
103NEK10.41581599
104WNK10.40979385
105MUSK0.40018352
106NEK90.39443949
107ADRBK10.39168251
108PAK10.38684706
109MKNK20.38684161
110SCYL20.38545087
111EIF2AK10.38108044
112MAPK70.37495000
113AURKA0.37404972
114PBK0.37378165
115DYRK20.37300754
116CDK120.37197309
117CAMKK20.37174367
118PRKACB0.37000827
119FGFR10.36658161
120BUB10.35230337
121TESK20.34562766
122MAPKAPK20.34128838
123AURKB0.33923152
124WNK40.33645701
125PTK20.33643399
126EPHA30.33378150
127BMX0.33255880
128CSNK1A1L0.33005258
129INSR0.32898594
130GRK70.32663973
131CDK60.31887754
132SIK10.31554344
133IGF1R0.30934684
134STK380.30918468
135RIPK10.30714147
136NLK0.30705250
137MKNK10.30573954
138NEK20.29289473
139MST1R0.29109757
140RPS6KB20.28567222
141TGFBR10.28532427
142PRKCE0.28523177
143CAMK1D0.28339526
144PRKG10.27967220
145MAPK30.26499879
146MAPK10.26465843
147NTRK10.26437064
148EIF2AK20.25715155
149CSNK1G10.25420494
150MELK0.24299235
151PLK30.23242994

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045125.54402139
2Olfactory transduction_Homo sapiens_hsa047404.86716400
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.83913289
4Protein digestion and absorption_Homo sapiens_hsa049744.08581578
5PPAR signaling pathway_Homo sapiens_hsa033204.01684398
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.26210597
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.16503535
8Phenylalanine metabolism_Homo sapiens_hsa003603.14135197
9Sphingolipid metabolism_Homo sapiens_hsa006002.67285590
10Focal adhesion_Homo sapiens_hsa045102.56085275
11Fatty acid degradation_Homo sapiens_hsa000712.55745322
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.44556232
13Propanoate metabolism_Homo sapiens_hsa006402.33328835
14Fatty acid metabolism_Homo sapiens_hsa012122.28469429
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.28293645
16Glycerolipid metabolism_Homo sapiens_hsa005612.20850119
17TGF-beta signaling pathway_Homo sapiens_hsa043502.17147592
18Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.01403344
19Sulfur metabolism_Homo sapiens_hsa009201.94946878
20Tyrosine metabolism_Homo sapiens_hsa003501.90991572
21Steroid biosynthesis_Homo sapiens_hsa001001.89072638
22PI3K-Akt signaling pathway_Homo sapiens_hsa041511.88309942
23Malaria_Homo sapiens_hsa051441.86878184
24Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.81076335
25Sulfur relay system_Homo sapiens_hsa041221.75178000
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.74177037
27Arachidonic acid metabolism_Homo sapiens_hsa005901.67350293
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.64559274
29Other glycan degradation_Homo sapiens_hsa005111.58997854
30Hippo signaling pathway_Homo sapiens_hsa043901.55799057
31Tryptophan metabolism_Homo sapiens_hsa003801.54788450
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.53807802
33Carbon metabolism_Homo sapiens_hsa012001.50520719
34Adipocytokine signaling pathway_Homo sapiens_hsa049201.48951547
35Dilated cardiomyopathy_Homo sapiens_hsa054141.48798538
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.48563960
37Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.46159675
38Ovarian steroidogenesis_Homo sapiens_hsa049131.41306011
39Arginine and proline metabolism_Homo sapiens_hsa003301.32262754
40Proteoglycans in cancer_Homo sapiens_hsa052051.25867134
41Adherens junction_Homo sapiens_hsa045201.24450981
42Fat digestion and absorption_Homo sapiens_hsa049751.23643480
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22222695
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.18460718
45Tight junction_Homo sapiens_hsa045301.15868899
46Arginine biosynthesis_Homo sapiens_hsa002201.15397395
47Protein export_Homo sapiens_hsa030601.12523941
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.12167430
49Vibrio cholerae infection_Homo sapiens_hsa051101.06068015
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05035436
51Phagosome_Homo sapiens_hsa041451.04805067
52Selenocompound metabolism_Homo sapiens_hsa004501.00099025
53Hedgehog signaling pathway_Homo sapiens_hsa043400.97621552
54Biosynthesis of amino acids_Homo sapiens_hsa012300.97209083
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93633040
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92774676
57Bladder cancer_Homo sapiens_hsa052190.91595890
58Basal cell carcinoma_Homo sapiens_hsa052170.90933669
59Folate biosynthesis_Homo sapiens_hsa007900.89272917
60Lysine degradation_Homo sapiens_hsa003100.82237897
61Starch and sucrose metabolism_Homo sapiens_hsa005000.80711460
62Melanoma_Homo sapiens_hsa052180.79510945
63Amoebiasis_Homo sapiens_hsa051460.79232854
64Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78120255
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76139287
66Vitamin B6 metabolism_Homo sapiens_hsa007500.75976225
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75719520
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74559897
69Gap junction_Homo sapiens_hsa045400.73503722
70Insulin signaling pathway_Homo sapiens_hsa049100.73373216
71Retinol metabolism_Homo sapiens_hsa008300.72404994
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71554422
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71544187
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.71386484
75Rap1 signaling pathway_Homo sapiens_hsa040150.69258972
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69224273
77Histidine metabolism_Homo sapiens_hsa003400.69190471
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66832176
79Phototransduction_Homo sapiens_hsa047440.66075758
80Pentose phosphate pathway_Homo sapiens_hsa000300.66053828
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63978089
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63907742
83Glutathione metabolism_Homo sapiens_hsa004800.61449843
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60636661
85Fatty acid elongation_Homo sapiens_hsa000620.59222719
86Renin-angiotensin system_Homo sapiens_hsa046140.59144157
87Small cell lung cancer_Homo sapiens_hsa052220.59091591
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58811030
89Ras signaling pathway_Homo sapiens_hsa040140.58443493
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57701235
91Galactose metabolism_Homo sapiens_hsa000520.56197235
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55365547
93Pathways in cancer_Homo sapiens_hsa052000.54541906
94MicroRNAs in cancer_Homo sapiens_hsa052060.53448085
95Axon guidance_Homo sapiens_hsa043600.52793413
96Thyroid hormone synthesis_Homo sapiens_hsa049180.52021823
97Melanogenesis_Homo sapiens_hsa049160.49235770
98Wnt signaling pathway_Homo sapiens_hsa043100.49176365
99Insulin resistance_Homo sapiens_hsa049310.48119157
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.47550363
101Butanoate metabolism_Homo sapiens_hsa006500.47488460
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.45938500
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44947637
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44544584
105Peroxisome_Homo sapiens_hsa041460.44489971
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43523015
107Prostate cancer_Homo sapiens_hsa052150.43480239
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42253653
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.42084028
110Renin secretion_Homo sapiens_hsa049240.38949037
111Renal cell carcinoma_Homo sapiens_hsa052110.38832586
112Mineral absorption_Homo sapiens_hsa049780.38520679
113Nitrogen metabolism_Homo sapiens_hsa009100.37806521
114Ether lipid metabolism_Homo sapiens_hsa005650.37354312
115Salivary secretion_Homo sapiens_hsa049700.36737249
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.35583214
117Prion diseases_Homo sapiens_hsa050200.33779881
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33704937
119Purine metabolism_Homo sapiens_hsa002300.33220238
120Fatty acid biosynthesis_Homo sapiens_hsa000610.33200353
121Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33015347
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.32651302
123Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32179896
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.32154743
125cAMP signaling pathway_Homo sapiens_hsa040240.32151497
126Notch signaling pathway_Homo sapiens_hsa043300.31918896
127Glucagon signaling pathway_Homo sapiens_hsa049220.30996246
128Cyanoamino acid metabolism_Homo sapiens_hsa004600.30579033
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30557152
130Taste transduction_Homo sapiens_hsa047420.29184492
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.29171162
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.27938798
133Viral myocarditis_Homo sapiens_hsa054160.27367296
134AMPK signaling pathway_Homo sapiens_hsa041520.26543710
135Apoptosis_Homo sapiens_hsa042100.26523805
136Metabolic pathways_Homo sapiens_hsa011000.25763504
137Chemical carcinogenesis_Homo sapiens_hsa052040.24969263
138One carbon pool by folate_Homo sapiens_hsa006700.24947120
139Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24507774
140HIF-1 signaling pathway_Homo sapiens_hsa040660.24193175
141Thyroid cancer_Homo sapiens_hsa052160.24005828
142Bile secretion_Homo sapiens_hsa049760.22837516
143Dorso-ventral axis formation_Homo sapiens_hsa043200.21938723
144Circadian rhythm_Homo sapiens_hsa047100.21607473
145Complement and coagulation cascades_Homo sapiens_hsa046100.19683943
146beta-Alanine metabolism_Homo sapiens_hsa004100.19371285
147Pyruvate metabolism_Homo sapiens_hsa006200.16271409
148Steroid hormone biosynthesis_Homo sapiens_hsa001400.15750992
149Cardiac muscle contraction_Homo sapiens_hsa042600.14135773

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