

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | cerebellar Purkinje cell layer development (GO:0021680) | 6.70497004 |
| 2 | fructose metabolic process (GO:0006000) | 6.15035862 |
| 3 | protein heterotetramerization (GO:0051290) | 6.00976059 |
| 4 | metanephric tubule development (GO:0072170) | 5.95594590 |
| 5 | metanephric nephron tubule development (GO:0072234) | 5.95594590 |
| 6 | C4-dicarboxylate transport (GO:0015740) | 5.87176440 |
| 7 | cellular potassium ion homeostasis (GO:0030007) | 5.82991326 |
| 8 | cell differentiation in hindbrain (GO:0021533) | 5.66108977 |
| 9 | positive regulation of phosphoprotein phosphatase activity (GO:0032516) | 5.56667766 |
| 10 | neurofilament cytoskeleton organization (GO:0060052) | 5.53518948 |
| 11 | synaptic vesicle exocytosis (GO:0016079) | 5.52230342 |
| 12 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 5.49287365 |
| 13 | collecting duct development (GO:0072044) | 5.45027156 |
| 14 | metanephric nephron epithelium development (GO:0072243) | 5.41821223 |
| 15 | cellular sodium ion homeostasis (GO:0006883) | 5.41674109 |
| 16 | neuronal action potential propagation (GO:0019227) | 5.23516305 |
| 17 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.15792216 |
| 18 | inositol phosphate-mediated signaling (GO:0048016) | 5.05629631 |
| 19 | musculoskeletal movement (GO:0050881) | 4.96316448 |
| 20 | multicellular organismal movement (GO:0050879) | 4.96316448 |
| 21 | metanephric epithelium development (GO:0072207) | 4.96078569 |
| 22 | retina layer formation (GO:0010842) | 4.94302863 |
| 23 | positive regulation of muscle hypertrophy (GO:0014742) | 4.94150566 |
| 24 | positive regulation of cardiac muscle hypertrophy (GO:0010613) | 4.94150566 |
| 25 | vocalization behavior (GO:0071625) | 4.80736112 |
| 26 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.78728387 |
| 27 | locomotory exploration behavior (GO:0035641) | 4.68589679 |
| 28 | behavioral response to nicotine (GO:0035095) | 4.67080878 |
| 29 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 4.66279180 |
| 30 | aggressive behavior (GO:0002118) | 4.60440350 |
| 31 | sodium ion export (GO:0071436) | 4.58670666 |
| 32 | neuron cell-cell adhesion (GO:0007158) | 4.53292245 |
| 33 | glutamate secretion (GO:0014047) | 4.51196937 |
| 34 | relaxation of smooth muscle (GO:0044557) | 4.49942666 |
| 35 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.48337822 |
| 36 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.46478886 |
| 37 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.42579985 |
| 38 | ATP synthesis coupled proton transport (GO:0015986) | 4.42579985 |
| 39 | synaptic vesicle maturation (GO:0016188) | 4.41908932 |
| 40 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 4.38494400 |
| 41 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.36274264 |
| 42 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.23750072 |
| 43 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.20506336 |
| 44 | positive regulation of amino acid transport (GO:0051957) | 4.17379666 |
| 45 | protein localization to synapse (GO:0035418) | 4.17216287 |
| 46 | positive regulation of glomerulus development (GO:0090193) | 4.12055945 |
| 47 | retinal cone cell development (GO:0046549) | 4.11188726 |
| 48 | synaptic transmission, dopaminergic (GO:0001963) | 4.08900247 |
| 49 | negative regulation of heart rate (GO:0010459) | 4.06280477 |
| 50 | neurotransmitter secretion (GO:0007269) | 4.04337482 |
| 51 | chemosensory behavior (GO:0007635) | 4.00991429 |
| 52 | neuron-neuron synaptic transmission (GO:0007270) | 3.98409863 |
| 53 | respiratory electron transport chain (GO:0022904) | 3.92358345 |
| 54 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.88609238 |
| 55 | dopamine biosynthetic process (GO:0042416) | 3.87472768 |
| 56 | regulation of synaptic vesicle transport (GO:1902803) | 3.83782939 |
| 57 | electron transport chain (GO:0022900) | 3.83758639 |
| 58 | regulation of synapse structural plasticity (GO:0051823) | 3.83619262 |
| 59 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.79629574 |
| 60 | striatum development (GO:0021756) | 3.78976525 |
| 61 | auditory receptor cell stereocilium organization (GO:0060088) | 3.78019733 |
| 62 | negative regulation of norepinephrine secretion (GO:0010700) | 3.77919674 |
| 63 | exploration behavior (GO:0035640) | 3.77485593 |
| 64 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.75614402 |
| 65 | innervation (GO:0060384) | 3.70939854 |
| 66 | behavioral response to cocaine (GO:0048148) | 3.70525465 |
| 67 | prepulse inhibition (GO:0060134) | 3.69604792 |
| 68 | relaxation of cardiac muscle (GO:0055119) | 3.68895391 |
| 69 | glutamate receptor signaling pathway (GO:0007215) | 3.68865849 |
| 70 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.65030920 |
| 71 | regulation of potassium ion transmembrane transporter activity (GO:1901016) | 3.63750161 |
| 72 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.61960644 |
| 73 | ATP hydrolysis coupled proton transport (GO:0015991) | 3.60788840 |
| 74 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 3.60788840 |
| 75 | synaptic transmission, glutamatergic (GO:0035249) | 3.58401507 |
| 76 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.58369524 |
| 77 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.56827301 |
| 78 | transmission of nerve impulse (GO:0019226) | 3.55086685 |
| 79 | neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976) | 3.54282777 |
| 80 | serotonin metabolic process (GO:0042428) | 3.52847470 |
| 81 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.52712991 |
| 82 | endoplasmic reticulum calcium ion homeostasis (GO:0032469) | 3.51823714 |
| 83 | nephron tubule development (GO:0072080) | 3.49250145 |
| 84 | long-term synaptic potentiation (GO:0060291) | 3.49083114 |
| 85 | potassium ion homeostasis (GO:0055075) | 3.48663536 |
| 86 | long term synaptic depression (GO:0060292) | 3.45907102 |
| 87 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 3.44874759 |
| 88 | regulation of glutamate secretion (GO:0014048) | 3.42556224 |
| 89 | G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199 | 3.41495620 |
| 90 | regulation of protein kinase A signaling (GO:0010738) | 3.41087516 |
| 91 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.40742448 |
| 92 | cGMP metabolic process (GO:0046068) | 3.40137015 |
| 93 | neurotransmitter transport (GO:0006836) | 3.39933144 |
| 94 | neuron recognition (GO:0008038) | 3.39276347 |
| 95 | relaxation of muscle (GO:0090075) | 3.38796258 |
| 96 | response to histamine (GO:0034776) | 3.38203849 |
| 97 | parturition (GO:0007567) | 3.37803508 |
| 98 | regulation of potassium ion transmembrane transport (GO:1901379) | 3.36720043 |
| 99 | chaperone-mediated protein transport (GO:0072321) | 3.36530453 |
| 100 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 3.35693241 |
| 101 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.34793936 |
| 102 | neuromuscular process controlling posture (GO:0050884) | 3.31238873 |
| 103 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.30908441 |
| 104 | proline transport (GO:0015824) | 3.30622976 |
| 105 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.30008801 |
| 106 | regulation of dopamine uptake involved in synaptic transmission (GO:0051584) | 3.29228298 |
| 107 | regulation of catecholamine uptake involved in synaptic transmission (GO:0051940) | 3.29228298 |
| 108 | negative regulation of dendrite morphogenesis (GO:0050774) | 3.28523523 |
| 109 | detection of calcium ion (GO:0005513) | 3.25786892 |
| 110 | synaptic vesicle endocytosis (GO:0048488) | 3.25521933 |
| 111 | gamma-aminobutyric acid transport (GO:0015812) | 3.25220055 |
| 112 | hydrogen ion transmembrane transport (GO:1902600) | 3.23845395 |
| 113 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.22595523 |
| 114 | mating behavior (GO:0007617) | 3.22382994 |
| 115 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.22169967 |
| 116 | long-term memory (GO:0007616) | 3.21854384 |
| 117 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.21495543 |
| 118 | regulation of neurotransmitter levels (GO:0001505) | 3.21287639 |
| 119 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.20383018 |
| 120 | regulation of postsynaptic membrane potential (GO:0060078) | 3.18286129 |
| 121 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.17737056 |
| 122 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.16526226 |
| 123 | adult walking behavior (GO:0007628) | 3.16191612 |
| 124 | activation of protein kinase A activity (GO:0034199) | 3.15949904 |
| 125 | renal tubule development (GO:0061326) | 3.15034458 |
| 126 | regulation of neurotransmitter secretion (GO:0046928) | 3.14058866 |
| 127 | regulation of vesicle fusion (GO:0031338) | 3.13819959 |
| 128 | negative regulation of fatty acid transport (GO:2000192) | 3.13324792 |
| 129 | nitric oxide biosynthetic process (GO:0006809) | 3.13310065 |
| 130 | regulation of amine transport (GO:0051952) | 3.12978909 |
| 131 | cerebellar granule cell differentiation (GO:0021707) | 3.12491523 |
| 132 | calcium-mediated signaling using intracellular calcium source (GO:0035584) | 3.11409653 |
| 133 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.10056232 |
| 134 | layer formation in cerebral cortex (GO:0021819) | 3.09138565 |
| 135 | regulation of synaptic plasticity (GO:0048167) | 3.09010428 |
| 136 | regulation of dopamine secretion (GO:0014059) | 3.08220724 |
| 137 | endocrine hormone secretion (GO:0060986) | 3.06650527 |
| 138 | primary amino compound metabolic process (GO:1901160) | 3.06387664 |
| 139 | sodium ion homeostasis (GO:0055078) | 3.06350148 |
| 140 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.05269001 |
| 141 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.04921933 |
| 142 | regulation of dopamine metabolic process (GO:0042053) | 3.04837442 |
| 143 | regulation of catecholamine metabolic process (GO:0042069) | 3.04837442 |
| 144 | positive regulation of membrane potential (GO:0045838) | 3.04259907 |
| 145 | axonal fasciculation (GO:0007413) | 3.03454576 |
| 146 | regulation of neurotransmitter transport (GO:0051588) | 3.03033457 |
| 147 | behavioral defense response (GO:0002209) | 3.02268531 |
| 148 | behavioral fear response (GO:0001662) | 3.02268531 |
| 149 | response to ammonium ion (GO:0060359) | 3.00336634 |
| 150 | presynaptic membrane organization (GO:0097090) | 2.98884448 |
| 151 | negative regulation of catecholamine secretion (GO:0033604) | 2.98771213 |
| 152 | membrane depolarization (GO:0051899) | 2.96806029 |
| 153 | membrane hyperpolarization (GO:0060081) | 2.96398413 |
| 154 | inner ear receptor stereocilium organization (GO:0060122) | 2.95246883 |
| 155 | activation of protein kinase B activity (GO:0032148) | 2.93886380 |
| 156 | membrane depolarization during action potential (GO:0086010) | 2.92145548 |
| 157 | synaptic transmission (GO:0007268) | 2.91659169 |
| 158 | acidic amino acid transport (GO:0015800) | 2.90871754 |
| 159 | negative regulation of dendrite development (GO:2000171) | 2.90454686 |
| 160 | positive regulation of neurotransmitter transport (GO:0051590) | 2.90300629 |
| 161 | regulation of neurotransmitter uptake (GO:0051580) | 2.89786261 |
| 162 | transferrin transport (GO:0033572) | 2.89262199 |
| 163 | urinary tract smooth muscle contraction (GO:0014848) | 2.89226579 |
| 164 | cell migration in hindbrain (GO:0021535) | 2.88855939 |
| 165 | fear response (GO:0042596) | 2.88761363 |
| 166 | presynaptic membrane assembly (GO:0097105) | 2.88196135 |
| 167 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 2.88093343 |
| 168 | response to amphetamine (GO:0001975) | 2.86441676 |
| 169 | short-term memory (GO:0007614) | 10.0947257 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.94548272 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.73489163 |
| 3 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.40948973 |
| 4 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.32814628 |
| 5 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.24237669 |
| 6 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.91059839 |
| 7 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.82912315 |
| 8 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.82912315 |
| 9 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.81170996 |
| 10 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.78839588 |
| 11 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.77202224 |
| 12 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.75570654 |
| 13 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.60886757 |
| 14 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.60350547 |
| 15 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.59269188 |
| 16 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.56847535 |
| 17 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.56747080 |
| 18 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.48031733 |
| 19 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.40507681 |
| 20 | * CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 2.38791389 |
| 21 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.27157366 |
| 22 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.23761298 |
| 23 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.22537484 |
| 24 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.19823598 |
| 25 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.13405935 |
| 26 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.10823669 |
| 27 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.09932454 |
| 28 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.08759392 |
| 29 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.99689574 |
| 30 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.96582325 |
| 31 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.94758387 |
| 32 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.88776974 |
| 33 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.87758314 |
| 34 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.77202752 |
| 35 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.75810983 |
| 36 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.73419609 |
| 37 | P300_19829295_ChIP-Seq_ESCs_Human | 1.71483496 |
| 38 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.61074274 |
| 39 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.56541221 |
| 40 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.53242782 |
| 41 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.46276849 |
| 42 | * TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.46120849 |
| 43 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.45558315 |
| 44 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.44390717 |
| 45 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.43394263 |
| 46 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.43006448 |
| 47 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.42549662 |
| 48 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.41809907 |
| 49 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.41714955 |
| 50 | * SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.40616626 |
| 51 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.35987844 |
| 52 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.34945826 |
| 53 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.33806258 |
| 54 | VDR_22108803_ChIP-Seq_LS180_Human | 1.32702558 |
| 55 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.32699420 |
| 56 | EWS_26573619_Chip-Seq_HEK293_Human | 1.32516826 |
| 57 | FUS_26573619_Chip-Seq_HEK293_Human | 1.30025145 |
| 58 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.29943639 |
| 59 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.29000608 |
| 60 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.28451052 |
| 61 | * AR_25329375_ChIP-Seq_VCAP_Human | 1.28080902 |
| 62 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.27638680 |
| 63 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.26899799 |
| 64 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.24964895 |
| 65 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.23838004 |
| 66 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.23722153 |
| 67 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.22645048 |
| 68 | * CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.19670407 |
| 69 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.18961221 |
| 70 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.16343845 |
| 71 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.16264671 |
| 72 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.16054527 |
| 73 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.16033823 |
| 74 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.13946933 |
| 75 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.12369177 |
| 76 | STAT3_23295773_ChIP-Seq_U87_Human | 1.12199276 |
| 77 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 1.11272306 |
| 78 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.10162844 |
| 79 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.09505771 |
| 80 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.09365534 |
| 81 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.06462913 |
| 82 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.06224395 |
| 83 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.06198560 |
| 84 | * LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.04473376 |
| 85 | * PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.04343549 |
| 86 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.03682280 |
| 87 | AR_19668381_ChIP-Seq_PC3_Human | 1.02925224 |
| 88 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.02753607 |
| 89 | * TCF4_23295773_ChIP-Seq_U87_Human | 1.02500948 |
| 90 | * JUN_21703547_ChIP-Seq_K562_Human | 1.02264205 |
| 91 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.01522774 |
| 92 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.00350622 |
| 93 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.99353276 |
| 94 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.99288947 |
| 95 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.98860816 |
| 96 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.96460504 |
| 97 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.96318817 |
| 98 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.96204000 |
| 99 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.95299194 |
| 100 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.94122847 |
| 101 | * KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 0.94102152 |
| 102 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.93020872 |
| 103 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.92887404 |
| 104 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.91968453 |
| 105 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.91968453 |
| 106 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.91851240 |
| 107 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 0.91559363 |
| 108 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 0.89388432 |
| 109 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.87802419 |
| 110 | * SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.87676973 |
| 111 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.86798799 |
| 112 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.85931159 |
| 113 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.85607048 |
| 114 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.84538827 |
| 115 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.83185645 |
| 116 | * TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.82469068 |
| 117 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 0.82114966 |
| 118 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 0.81860954 |
| 119 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.81735817 |
| 120 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.81269327 |
| 121 | KDM2B_26808549_Chip-Seq_REH_Human | 0.81215195 |
| 122 | * TP53_18474530_ChIP-ChIP_U2OS_Human | 0.80870053 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.15031935 |
| 2 | MP0003880_abnormal_central_pattern | 5.08066512 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 3.87710452 |
| 4 | MP0002822_catalepsy | 3.57715773 |
| 5 | MP0009745_abnormal_behavioral_response | 3.47565072 |
| 6 | MP0009046_muscle_twitch | 3.39303320 |
| 7 | MP0001968_abnormal_touch/_nociception | 3.36525531 |
| 8 | MP0004270_analgesia | 3.32047303 |
| 9 | MP0002064_seizures | 3.27857594 |
| 10 | MP0002736_abnormal_nociception_after | 3.03132149 |
| 11 | MP0002063_abnormal_learning/memory/cond | 3.01859265 |
| 12 | MP0002572_abnormal_emotion/affect_behav | 2.77227057 |
| 13 | MP0002735_abnormal_chemical_nociception | 2.74868819 |
| 14 | MP0002272_abnormal_nervous_system | 2.70530605 |
| 15 | MP0001529_abnormal_vocalization | 2.70416637 |
| 16 | MP0002734_abnormal_mechanical_nocicepti | 2.66589694 |
| 17 | MP0001486_abnormal_startle_reflex | 2.57171686 |
| 18 | MP0001440_abnormal_grooming_behavior | 2.53037804 |
| 19 | MP0006276_abnormal_autonomic_nervous | 2.46856166 |
| 20 | MP0008875_abnormal_xenobiotic_pharmacok | 2.44170947 |
| 21 | MP0002733_abnormal_thermal_nociception | 2.39885815 |
| 22 | MP0001501_abnormal_sleep_pattern | 2.38004430 |
| 23 | MP0001970_abnormal_pain_threshold | 2.31903410 |
| 24 | MP0005423_abnormal_somatic_nervous | 2.14148216 |
| 25 | MP0002067_abnormal_sensory_capabilities | 2.12191018 |
| 26 | MP0005386_behavior/neurological_phenoty | 2.01715740 |
| 27 | MP0004924_abnormal_behavior | 2.01715740 |
| 28 | MP0002184_abnormal_innervation | 1.93201495 |
| 29 | MP0003011_delayed_dark_adaptation | 1.85490716 |
| 30 | MP0003879_abnormal_hair_cell | 1.85238876 |
| 31 | MP0008569_lethality_at_weaning | 1.77671492 |
| 32 | MP0001984_abnormal_olfaction | 1.77546776 |
| 33 | MP0001905_abnormal_dopamine_level | 1.71201397 |
| 34 | MP0002837_dystrophic_cardiac_calcinosis | 1.70305439 |
| 35 | MP0002557_abnormal_social/conspecific_i | 1.68301298 |
| 36 | MP0004811_abnormal_neuron_physiology | 1.57687923 |
| 37 | MP0004142_abnormal_muscle_tone | 1.54425978 |
| 38 | MP0000955_abnormal_spinal_cord | 1.51888371 |
| 39 | MP0000778_abnormal_nervous_system | 1.48730568 |
| 40 | MP0002909_abnormal_adrenal_gland | 1.48614474 |
| 41 | MP0003329_amyloid_beta_deposits | 1.48610083 |
| 42 | MP0000566_synostosis | 1.44205678 |
| 43 | MP0002066_abnormal_motor_capabilities/c | 1.41858217 |
| 44 | MP0004858_abnormal_nervous_system | 1.40388769 |
| 45 | MP0003122_maternal_imprinting | 1.38102275 |
| 46 | MP0006072_abnormal_retinal_apoptosis | 1.34477246 |
| 47 | MP0002882_abnormal_neuron_morphology | 1.32639024 |
| 48 | MP0005646_abnormal_pituitary_gland | 1.30003659 |
| 49 | MP0001502_abnormal_circadian_rhythm | 1.27172857 |
| 50 | MP0008872_abnormal_physiological_respon | 1.26517194 |
| 51 | MP0004043_abnormal_pH_regulation | 1.24597067 |
| 52 | MP0000751_myopathy | 1.21822586 |
| 53 | MP0001188_hyperpigmentation | 1.17205200 |
| 54 | MP0003137_abnormal_impulse_conducting | 1.16646761 |
| 55 | MP0008874_decreased_physiological_sensi | 1.12808530 |
| 56 | MP0004742_abnormal_vestibular_system | 1.11956666 |
| 57 | MP0003633_abnormal_nervous_system | 1.09191979 |
| 58 | MP0010386_abnormal_urinary_bladder | 1.07593217 |
| 59 | MP0002229_neurodegeneration | 1.07520473 |
| 60 | MP0008877_abnormal_DNA_methylation | 1.06825464 |
| 61 | MP0005535_abnormal_body_temperature | 1.06736522 |
| 62 | MP0009780_abnormal_chondrocyte_physiolo | 1.05719412 |
| 63 | MP0005410_abnormal_fertilization | 1.03884340 |
| 64 | MP0000358_abnormal_cell_content/ | 1.02283772 |
| 65 | MP0000003_abnormal_adipose_tissue | 1.02091204 |
| 66 | MP0004084_abnormal_cardiac_muscle | 0.97521326 |
| 67 | MP0005551_abnormal_eye_electrophysiolog | 0.96364319 |
| 68 | MP0003631_nervous_system_phenotype | 0.95340327 |
| 69 | MP0004145_abnormal_muscle_electrophysio | 0.94512225 |
| 70 | MP0004147_increased_porphyrin_level | 0.92055664 |
| 71 | MP0001963_abnormal_hearing_physiology | 0.91990638 |
| 72 | MP0002152_abnormal_brain_morphology | 0.89454985 |
| 73 | MP0002277_abnormal_respiratory_mucosa | 0.88577653 |
| 74 | MP0004085_abnormal_heartbeat | 0.88304445 |
| 75 | MP0004885_abnormal_endolymph | 0.87028987 |
| 76 | MP0001485_abnormal_pinna_reflex | 0.84993722 |
| 77 | MP0002069_abnormal_eating/drinking_beha | 0.84018862 |
| 78 | MP0005171_absent_coat_pigmentation | 0.83853588 |
| 79 | MP0002752_abnormal_somatic_nervous | 0.83492665 |
| 80 | MP0002876_abnormal_thyroid_physiology | 0.82926692 |
| 81 | MP0005253_abnormal_eye_physiology | 0.81614220 |
| 82 | MP0000013_abnormal_adipose_tissue | 0.81145677 |
| 83 | MP0005409_darkened_coat_color | 0.80805970 |
| 84 | MP0002090_abnormal_vision | 0.80604205 |
| 85 | MP0003123_paternal_imprinting | 0.80072178 |
| 86 | MP0001664_abnormal_digestion | 0.79663711 |
| 87 | MP0003634_abnormal_glial_cell | 0.78595410 |
| 88 | MP0005645_abnormal_hypothalamus_physiol | 0.78501854 |
| 89 | MP0006035_abnormal_mitochondrial_morpho | 0.78226815 |
| 90 | MP0004215_abnormal_myocardial_fiber | 0.75126817 |
| 91 | MP0003787_abnormal_imprinting | 0.75114156 |
| 92 | MP0005394_taste/olfaction_phenotype | 0.72714096 |
| 93 | MP0005499_abnormal_olfactory_system | 0.72714096 |
| 94 | MP0009697_abnormal_copulation | 0.71741088 |
| 95 | MP0003183_abnormal_peptide_metabolism | 0.69615878 |
| 96 | MP0000920_abnormal_myelination | 0.68475234 |
| 97 | MP0004036_abnormal_muscle_relaxation | 0.67787046 |
| 98 | MP0008775_abnormal_heart_ventricle | 0.67206579 |
| 99 | MP0004484_altered_response_of | 0.67073962 |
| 100 | MP0000538_abnormal_urinary_bladder | 0.66125747 |
| 101 | MP0001986_abnormal_taste_sensitivity | 0.66106976 |
| 102 | MP0003632_abnormal_nervous_system | 0.65398376 |
| 103 | MP0003121_genomic_imprinting | 0.65286641 |
| 104 | MP0005595_abnormal_vascular_smooth | 0.64856389 |
| 105 | MP0001299_abnormal_eye_distance/ | 0.64511437 |
| 106 | MP0002638_abnormal_pupillary_reflex | 0.63847619 |
| 107 | MP0000604_amyloidosis | 0.63697698 |
| 108 | MP0001348_abnormal_lacrimal_gland | 0.63202768 |
| 109 | MP0005623_abnormal_meninges_morphology | 0.62875305 |
| 110 | MP0003868_abnormal_feces_composition | 0.61587424 |
| 111 | MP0010329_abnormal_lipoprotein_level | 0.60610823 |
| 112 | MP0000631_abnormal_neuroendocrine_gland | 0.58279942 |
| 113 | MP0001765_abnormal_ion_homeostasis | 0.58214264 |
| 114 | MP0000534_abnormal_ureter_morphology | 0.57387509 |
| 115 | MP0000230_abnormal_systemic_arterial | 0.56721336 |
| 116 | MP0009379_abnormal_foot_pigmentation | 0.56482887 |
| 117 | MP0001756_abnormal_urination | 0.55531755 |
| 118 | MP0005620_abnormal_muscle_contractility | 0.54134864 |
| 119 | MP0001177_atelectasis | 0.53522733 |
| 120 | MP0003690_abnormal_glial_cell | 0.50874494 |
| 121 | MP0001943_abnormal_respiration | 0.50848227 |
| 122 | MP0000026_abnormal_inner_ear | 0.50175207 |
| 123 | MP0006036_abnormal_mitochondrial_physio | 0.49543002 |
| 124 | MP0005379_endocrine/exocrine_gland_phen | 0.49101404 |
| 125 | MP0005174_abnormal_tail_pigmentation | 0.48893947 |
| 126 | MP0003956_abnormal_body_size | 0.48660481 |
| 127 | MP0000569_abnormal_digit_pigmentation | 0.46154509 |
| 128 | MP0005220_abnormal_exocrine_pancreas | 0.45111938 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Myokymia (HP:0002411) | 8.57222504 |
| 2 | Focal motor seizures (HP:0011153) | 8.21670601 |
| 3 | Horizontal nystagmus (HP:0000666) | 5.93798524 |
| 4 | Focal seizures (HP:0007359) | 5.85722964 |
| 5 | Visual hallucinations (HP:0002367) | 5.56083572 |
| 6 | Atonic seizures (HP:0010819) | 5.43345607 |
| 7 | Intention tremor (HP:0002080) | 5.04630071 |
| 8 | Febrile seizures (HP:0002373) | 4.87421911 |
| 9 | Absence seizures (HP:0002121) | 4.59822946 |
| 10 | Epileptic encephalopathy (HP:0200134) | 4.32281185 |
| 11 | Dialeptic seizures (HP:0011146) | 4.13669670 |
| 12 | Generalized tonic-clonic seizures (HP:0002069) | 4.11686855 |
| 13 | Progressive cerebellar ataxia (HP:0002073) | 4.06229606 |
| 14 | Acute necrotizing encephalopathy (HP:0006965) | 3.91703479 |
| 15 | Abnormality of saccadic eye movements (HP:0000570) | 3.55742424 |
| 16 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.55187608 |
| 17 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 3.52243808 |
| 18 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 3.52243808 |
| 19 | Abnormality of ocular smooth pursuit (HP:0000617) | 3.52113817 |
| 20 | Progressive macrocephaly (HP:0004481) | 3.48311985 |
| 21 | Mitochondrial inheritance (HP:0001427) | 3.36551168 |
| 22 | Action tremor (HP:0002345) | 3.35523840 |
| 23 | Pheochromocytoma (HP:0002666) | 3.25905328 |
| 24 | Broad-based gait (HP:0002136) | 3.17851840 |
| 25 | Acute encephalopathy (HP:0006846) | 3.16296655 |
| 26 | Hyperventilation (HP:0002883) | 3.14622487 |
| 27 | Limb ataxia (HP:0002070) | 3.08992536 |
| 28 | Gaze-evoked nystagmus (HP:0000640) | 3.06791200 |
| 29 | Anxiety (HP:0000739) | 3.04976644 |
| 30 | Neuroendocrine neoplasm (HP:0100634) | 3.03075199 |
| 31 | Abnormal hair whorl (HP:0010721) | 2.99209834 |
| 32 | Truncal ataxia (HP:0002078) | 2.88093025 |
| 33 | Amblyopia (HP:0000646) | 2.83943820 |
| 34 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.80017984 |
| 35 | Abnormal eating behavior (HP:0100738) | 2.78914089 |
| 36 | Dysdiadochokinesis (HP:0002075) | 2.78167273 |
| 37 | Limb dystonia (HP:0002451) | 2.75349678 |
| 38 | Increased hepatocellular lipid droplets (HP:0006565) | 2.73703632 |
| 39 | Increased CSF lactate (HP:0002490) | 2.70487310 |
| 40 | Resting tremor (HP:0002322) | 2.69640514 |
| 41 | Supranuclear gaze palsy (HP:0000605) | 2.69531657 |
| 42 | Dysmetria (HP:0001310) | 2.68861272 |
| 43 | Gait ataxia (HP:0002066) | 2.64682494 |
| 44 | Poor eye contact (HP:0000817) | 2.62283736 |
| 45 | Sensory axonal neuropathy (HP:0003390) | 2.62261942 |
| 46 | Depression (HP:0000716) | 2.58841602 |
| 47 | Scanning speech (HP:0002168) | 2.56730335 |
| 48 | Impaired vibratory sensation (HP:0002495) | 2.54861281 |
| 49 | Progressive inability to walk (HP:0002505) | 2.54115099 |
| 50 | Impaired social interactions (HP:0000735) | 2.52886839 |
| 51 | Abnormal social behavior (HP:0012433) | 2.52886839 |
| 52 | Focal dystonia (HP:0004373) | 2.51578383 |
| 53 | Myotonia (HP:0002486) | 2.49297563 |
| 54 | Hepatocellular necrosis (HP:0001404) | 2.47631223 |
| 55 | Ankle clonus (HP:0011448) | 2.46462394 |
| 56 | Torticollis (HP:0000473) | 2.46364028 |
| 57 | Optic disc pallor (HP:0000543) | 2.41069203 |
| 58 | Failure to thrive in infancy (HP:0001531) | 2.39257786 |
| 59 | Craniofacial dystonia (HP:0012179) | 2.33724257 |
| 60 | Renal Fanconi syndrome (HP:0001994) | 2.31999861 |
| 61 | Polyphagia (HP:0002591) | 2.27567557 |
| 62 | Annular pancreas (HP:0001734) | 2.25143810 |
| 63 | Lipid accumulation in hepatocytes (HP:0006561) | 2.24861942 |
| 64 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.22177514 |
| 65 | Gait imbalance (HP:0002141) | 2.20558452 |
| 66 | Autoamputation (HP:0001218) | 2.18597867 |
| 67 | Spastic gait (HP:0002064) | 2.16772258 |
| 68 | Mutism (HP:0002300) | 2.16328640 |
| 69 | Excessive salivation (HP:0003781) | 2.15716123 |
| 70 | Drooling (HP:0002307) | 2.15716123 |
| 71 | Delusions (HP:0000746) | 2.15454501 |
| 72 | Hyperlipoproteinemia (HP:0010980) | 2.15416988 |
| 73 | Insidious onset (HP:0003587) | 2.15153076 |
| 74 | Termporal pattern (HP:0011008) | 2.15153076 |
| 75 | Bradykinesia (HP:0002067) | 2.14198433 |
| 76 | Cerebral inclusion bodies (HP:0100314) | 2.13969250 |
| 77 | Epileptiform EEG discharges (HP:0011182) | 2.13249458 |
| 78 | Urinary urgency (HP:0000012) | 2.13068852 |
| 79 | Fetal akinesia sequence (HP:0001989) | 2.12779216 |
| 80 | Abnormality of the anterior horn cell (HP:0006802) | 2.12314686 |
| 81 | Degeneration of anterior horn cells (HP:0002398) | 2.12314686 |
| 82 | Neoplasm of the peripheral nervous system (HP:0100007) | 2.12217765 |
| 83 | Hypoventilation (HP:0002791) | 2.11138713 |
| 84 | Status epilepticus (HP:0002133) | 2.09797562 |
| 85 | Psychosis (HP:0000709) | 2.08616734 |
| 86 | Leukodystrophy (HP:0002415) | 2.08569506 |
| 87 | EEG with generalized epileptiform discharges (HP:0011198) | 2.07724633 |
| 88 | Cerebellar atrophy (HP:0001272) | 2.07503652 |
| 89 | Increased intramyocellular lipid droplets (HP:0012240) | 2.07248433 |
| 90 | Poor suck (HP:0002033) | 2.02778046 |
| 91 | Postural instability (HP:0002172) | 2.02266875 |
| 92 | Impaired smooth pursuit (HP:0007772) | 2.00854210 |
| 93 | Incomplete penetrance (HP:0003829) | 1.99259360 |
| 94 | Inability to walk (HP:0002540) | 1.98774394 |
| 95 | X-linked dominant inheritance (HP:0001423) | 1.97042341 |
| 96 | Stereotypic behavior (HP:0000733) | 1.96969669 |
| 97 | Generalized myoclonic seizures (HP:0002123) | 1.96723895 |
| 98 | Hypothermia (HP:0002045) | 1.95793959 |
| 99 | Papilledema (HP:0001085) | 1.95656211 |
| 100 | Cerebral edema (HP:0002181) | 1.94435794 |
| 101 | Congenital primary aphakia (HP:0007707) | 1.93955061 |
| 102 | Hemiparesis (HP:0001269) | 1.93895983 |
| 103 | Hypsarrhythmia (HP:0002521) | 1.93241635 |
| 104 | Short chin (HP:0000331) | 1.92763648 |
| 105 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.91727238 |
| 106 | Increased serum pyruvate (HP:0003542) | 1.90875348 |
| 107 | Abnormality of binocular vision (HP:0011514) | 1.89843463 |
| 108 | Diplopia (HP:0000651) | 1.89843463 |
| 109 | Dysmetric saccades (HP:0000641) | 1.89476840 |
| 110 | Postural tremor (HP:0002174) | 1.85747086 |
| 111 | Agitation (HP:0000713) | 1.84296279 |
| 112 | Dysarthria (HP:0001260) | 1.83164226 |
| 113 | Slow progression (HP:0003677) | 1.82735709 |
| 114 | Medial flaring of the eyebrow (HP:0010747) | 1.81620235 |
| 115 | Abnormality of the corticospinal tract (HP:0002492) | 1.79870256 |
| 116 | Sudden death (HP:0001699) | 1.79707051 |
| 117 | Abnormality of the lower motor neuron (HP:0002366) | 1.76908350 |
| 118 | Esotropia (HP:0000565) | 1.74748119 |
| 119 | Epidermoid cyst (HP:0200040) | 1.69410232 |
| 120 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.63738937 |
| 121 | Athetosis (HP:0002305) | 1.62883269 |
| 122 | Abnormality of glycolysis (HP:0004366) | 1.60692345 |
| 123 | Choroideremia (HP:0001139) | 1.59149287 |
| 124 | Hemiplegia (HP:0002301) | 1.57215558 |
| 125 | Hepatic necrosis (HP:0002605) | 1.54569391 |
| 126 | Respiratory failure (HP:0002878) | 1.54491964 |
| 127 | Genital tract atresia (HP:0001827) | 1.50960572 |
| 128 | Exertional dyspnea (HP:0002875) | 1.49623464 |
| 129 | Syncope (HP:0001279) | 1.48215598 |
| 130 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.48011125 |
| 131 | Heterochromia iridis (HP:0001100) | 1.47867203 |
| 132 | Exercise intolerance (HP:0003546) | 1.46783747 |
| 133 | Vaginal atresia (HP:0000148) | 1.46308180 |
| 134 | Nephrogenic diabetes insipidus (HP:0009806) | 1.44851155 |
| 135 | Intellectual disability, mild (HP:0001256) | 1.44241634 |
| 136 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.43396632 |
| 137 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.43396632 |
| 138 | Aplasia involving bones of the extremities (HP:0009825) | 1.42271873 |
| 139 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.42271873 |
| 140 | Aplasia of the phalanges of the hand (HP:0009802) | 1.42271873 |
| 141 | Abnormality of renal resorption (HP:0011038) | 1.41079112 |
| 142 | Increased muscle lipid content (HP:0009058) | 1.39364784 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NTRK3 | 4.59065633 |
| 2 | MAP3K12 | 3.67347550 |
| 3 | EPHA4 | 3.59135132 |
| 4 | MAP3K9 | 3.38818586 |
| 5 | MAP3K4 | 3.34547607 |
| 6 | MAP2K7 | 2.94992657 |
| 7 | RIPK4 | 2.77421955 |
| 8 | MINK1 | 2.73790837 |
| 9 | CSNK1G3 | 2.66263490 |
| 10 | GRK5 | 2.54684993 |
| 11 | CSNK1A1L | 2.49377980 |
| 12 | MAP2K4 | 2.39078476 |
| 13 | CASK | 2.35241889 |
| 14 | PNCK | 2.32890939 |
| 15 | CSNK1G1 | 2.25637362 |
| 16 | ARAF | 2.19914515 |
| 17 | CDK19 | 2.09773295 |
| 18 | TTK | 1.94833365 |
| 19 | DAPK2 | 1.84275727 |
| 20 | MARK1 | 1.82588449 |
| 21 | CAMKK2 | 1.82077814 |
| 22 | KSR2 | 1.80916715 |
| 23 | PLK2 | 1.80682734 |
| 24 | PAK6 | 1.64840315 |
| 25 | CAMKK1 | 1.55866950 |
| 26 | TESK1 | 1.54021581 |
| 27 | PRKG2 | 1.50356567 |
| 28 | DAPK1 | 1.46795927 |
| 29 | PRKG1 | 1.45900800 |
| 30 | GRK7 | 1.41066436 |
| 31 | TNIK | 1.39455306 |
| 32 | NTRK2 | 1.34186899 |
| 33 | MAPK13 | 1.34061394 |
| 34 | PTK6 | 1.34035109 |
| 35 | CDK5 | 1.30894031 |
| 36 | NME1 | 1.28964606 |
| 37 | OXSR1 | 1.26405600 |
| 38 | NTRK1 | 1.26166504 |
| 39 | BMPR2 | 1.21032876 |
| 40 | KSR1 | 1.20664374 |
| 41 | FRK | 1.18742442 |
| 42 | MAP4K2 | 1.18179259 |
| 43 | PTK2B | 1.17679080 |
| 44 | PRKCG | 1.16193735 |
| 45 | FES | 1.09424002 |
| 46 | MAP3K2 | 1.06647197 |
| 47 | SIK2 | 1.06356393 |
| 48 | FGFR2 | 1.04627393 |
| 49 | SIK3 | 1.01861657 |
| 50 | LATS2 | 1.00901020 |
| 51 | TRIM28 | 1.00455639 |
| 52 | PAK4 | 1.00257558 |
| 53 | UHMK1 | 0.97831424 |
| 54 | CAMK2A | 0.97595504 |
| 55 | ADRBK1 | 0.96105983 |
| 56 | MUSK | 0.96043381 |
| 57 | MAP3K13 | 0.93552132 |
| 58 | FGR | 0.91174977 |
| 59 | CDK3 | 0.90564179 |
| 60 | CDK18 | 0.88425341 |
| 61 | RET | 0.87495473 |
| 62 | WNK1 | 0.85414774 |
| 63 | MYLK | 0.84526421 |
| 64 | CDK14 | 0.83512511 |
| 65 | CDK15 | 0.83062234 |
| 66 | PRKCA | 0.82906601 |
| 67 | STK38 | 0.82421066 |
| 68 | TNK2 | 0.81845355 |
| 69 | LMTK2 | 0.77075753 |
| 70 | TAF1 | 0.76264774 |
| 71 | PHKG2 | 0.74740510 |
| 72 | PHKG1 | 0.74740510 |
| 73 | CDK11A | 0.73006707 |
| 74 | PRPF4B | 0.72881288 |
| 75 | LIMK1 | 0.72438141 |
| 76 | CAMK2B | 0.72416828 |
| 77 | ADRBK2 | 0.72243064 |
| 78 | PRKD3 | 0.71368272 |
| 79 | MAP3K6 | 0.69912367 |
| 80 | SGK494 | 0.68225100 |
| 81 | SGK223 | 0.68225100 |
| 82 | CAMK1 | 0.67557297 |
| 83 | STK39 | 0.65771109 |
| 84 | BMPR1B | 0.65380400 |
| 85 | GRK6 | 0.64443742 |
| 86 | AKT3 | 0.64203668 |
| 87 | RAF1 | 0.63518692 |
| 88 | TYRO3 | 0.63448339 |
| 89 | CAMK2G | 0.61553596 |
| 90 | CSNK1G2 | 0.60821985 |
| 91 | PDK1 | 0.59869313 |
| 92 | PDPK1 | 0.59845106 |
| 93 | WNK3 | 0.59648225 |
| 94 | BRAF | 0.59140219 |
| 95 | CSNK1D | 0.58402895 |
| 96 | PRKDC | 0.57560960 |
| 97 | MAP2K1 | 0.57141259 |
| 98 | ILK | 0.57034486 |
| 99 | BCR | 0.56775363 |
| 100 | STK11 | 0.56501136 |
| 101 | DAPK3 | 0.56167759 |
| 102 | WNK4 | 0.54833460 |
| 103 | FER | 0.54658431 |
| 104 | MAP3K11 | 0.54623284 |
| 105 | DYRK1A | 0.54231134 |
| 106 | MAPKAPK5 | 0.53421672 |
| 107 | PRKCE | 0.52498389 |
| 108 | CAMK2D | 0.50321342 |
| 109 | ROCK2 | 0.49981393 |
| 110 | CSNK1E | 0.49361680 |
| 111 | PRKCH | 0.49266148 |
| 112 | GRK1 | 0.47902619 |
| 113 | SRC | 0.46956710 |
| 114 | PRKCB | 0.45518182 |
| 115 | PINK1 | 0.45329568 |
| 116 | PRKACA | 0.44038656 |
| 117 | SGK1 | 0.44003119 |
| 118 | TSSK6 | 0.43970388 |
| 119 | SGK2 | 0.43798047 |
| 120 | PAK3 | 0.43643485 |
| 121 | CAMK1G | 0.42887513 |
| 122 | MAP3K1 | 0.40082332 |
| 123 | SCYL2 | 0.38117429 |
| 124 | FYN | 0.34953333 |
| 125 | PRKACG | 0.34840774 |
| 126 | PRKCZ | 0.34566337 |
| 127 | MARK2 | 0.34375113 |
| 128 | MOS | 0.33166105 |
| 129 | RPS6KA3 | 0.32592322 |
| 130 | CSNK1A1 | 0.32093094 |
| 131 | CAMK4 | 0.32088977 |
| 132 | EIF2AK1 | 0.30837603 |
| 133 | STK16 | 0.29716390 |
| 134 | RPS6KB1 | 0.29413350 |
| 135 | INSRR | 0.26714416 |
| 136 | CHEK2 | 0.23439358 |
| 137 | PRKAA1 | 0.23034801 |
| 138 | MAPK1 | 0.22938102 |
| 139 | ITK | 0.20174375 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nitrogen metabolism_Homo sapiens_hsa00910 | 4.95471923 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.71004455 |
| 3 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.47988937 |
| 4 | Nicotine addiction_Homo sapiens_hsa05033 | 3.25692323 |
| 5 | Parkinsons disease_Homo sapiens_hsa05012 | 3.13138854 |
| 6 | Olfactory transduction_Homo sapiens_hsa04740 | 2.75445082 |
| 7 | Alzheimers disease_Homo sapiens_hsa05010 | 2.67589738 |
| 8 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.54160726 |
| 9 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.50099372 |
| 10 | Long-term potentiation_Homo sapiens_hsa04720 | 2.43700006 |
| 11 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.42697886 |
| 12 | GABAergic synapse_Homo sapiens_hsa04727 | 2.39229607 |
| 13 | Circadian entrainment_Homo sapiens_hsa04713 | 2.35393291 |
| 14 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.33379117 |
| 15 | Morphine addiction_Homo sapiens_hsa05032 | 2.29825854 |
| 16 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.16905836 |
| 17 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.06582509 |
| 18 | Huntingtons disease_Homo sapiens_hsa05016 | 2.02150498 |
| 19 | Taste transduction_Homo sapiens_hsa04742 | 1.98678359 |
| 20 | Salivary secretion_Homo sapiens_hsa04970 | 1.98024302 |
| 21 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.88099742 |
| 22 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.75200806 |
| 23 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.72465140 |
| 24 | Renin secretion_Homo sapiens_hsa04924 | 1.69556493 |
| 25 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.69250598 |
| 26 | Long-term depression_Homo sapiens_hsa04730 | 1.68276374 |
| 27 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.66012448 |
| 28 | Insulin secretion_Homo sapiens_hsa04911 | 1.59990592 |
| 29 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.57475043 |
| 30 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.52567164 |
| 31 | Cocaine addiction_Homo sapiens_hsa05030 | 1.51529481 |
| 32 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.49849803 |
| 33 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.45334420 |
| 34 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.45330964 |
| 35 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.44854253 |
| 36 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.39200891 |
| 37 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.37134470 |
| 38 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.32714014 |
| 39 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.30064885 |
| 40 | Phototransduction_Homo sapiens_hsa04744 | 1.24980763 |
| 41 | Protein export_Homo sapiens_hsa03060 | 1.23329879 |
| 42 | Gap junction_Homo sapiens_hsa04540 | 1.17016204 |
| 43 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.10639209 |
| 44 | Circadian rhythm_Homo sapiens_hsa04710 | 1.05785455 |
| 45 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 1.05331306 |
| 46 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.99975524 |
| 47 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.98130840 |
| 48 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.97272877 |
| 49 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.94751504 |
| 50 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.90000156 |
| 51 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.89312804 |
| 52 | Glioma_Homo sapiens_hsa05214 | 0.88483660 |
| 53 | Melanogenesis_Homo sapiens_hsa04916 | 0.88140366 |
| 54 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.87826216 |
| 55 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.87367777 |
| 56 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.78951297 |
| 57 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.77406017 |
| 58 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.74635401 |
| 59 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.71685130 |
| 60 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.69731662 |
| 61 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.68626004 |
| 62 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.68111276 |
| 63 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.67097725 |
| 64 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.65947775 |
| 65 | Axon guidance_Homo sapiens_hsa04360 | 0.64358280 |
| 66 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.59559077 |
| 67 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.59288799 |
| 68 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.59077412 |
| 69 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.58886333 |
| 70 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.58513344 |
| 71 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.58179172 |
| 72 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.55345553 |
| 73 | Mineral absorption_Homo sapiens_hsa04978 | 0.53469672 |
| 74 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.52078961 |
| 75 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.52018369 |
| 76 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.51745855 |
| 77 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.51273844 |
| 78 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.50661588 |
| 79 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.49868894 |
| 80 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.49577875 |
| 81 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.44513154 |
| 82 | Alcoholism_Homo sapiens_hsa05034 | 0.44180426 |
| 83 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.43410448 |
| 84 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.43056143 |
| 85 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.43042513 |
| 86 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.41694818 |
| 87 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.39498036 |
| 88 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.38948260 |
| 89 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.38430895 |
| 90 | Carbon metabolism_Homo sapiens_hsa01200 | 0.37713785 |
| 91 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.37392735 |
| 92 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.36384057 |
| 93 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.35519685 |
| 94 | Prion diseases_Homo sapiens_hsa05020 | 0.33207198 |
| 95 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.32566022 |
| 96 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.32247411 |
| 97 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.31918148 |
| 98 | Phagosome_Homo sapiens_hsa04145 | 0.30930176 |
| 99 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.30304509 |
| 100 | Bile secretion_Homo sapiens_hsa04976 | 0.30068487 |
| 101 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.30035739 |
| 102 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.29277834 |
| 103 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.25964967 |
| 104 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.25665536 |
| 105 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.23751571 |
| 106 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.23651495 |
| 107 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.21410735 |
| 108 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.20773801 |
| 109 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.18535686 |
| 110 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.18186344 |
| 111 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.17954842 |
| 112 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.17752310 |
| 113 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.17510377 |
| 114 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.17143284 |
| 115 | Endocytosis_Homo sapiens_hsa04144 | 0.16935891 |
| 116 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.16927869 |
| 117 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.16372726 |
| 118 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.16045256 |
| 119 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.15545607 |
| 120 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.13967795 |
| 121 | Metabolic pathways_Homo sapiens_hsa01100 | 0.13768970 |
| 122 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.12758925 |
| 123 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.12286049 |
| 124 | Retinol metabolism_Homo sapiens_hsa00830 | 0.11395964 |
| 125 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.09952841 |
| 126 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.09614611 |
| 127 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.07067591 |
| 128 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.05234950 |

