PCP4L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of DNA methylation (GO:0044030)8.98747621
2regulation of female gonad development (GO:2000194)7.72701192
3regulation of acrosome reaction (GO:0060046)6.82250839
4piRNA metabolic process (GO:0034587)6.78381056
5negative regulation of retinoic acid receptor signaling pathway (GO:0048387)6.65917505
6retinal cone cell development (GO:0046549)6.57930879
7meiotic cell cycle (GO:0051321)6.32518245
8regulation of meiosis I (GO:0060631)5.94893514
9regulation of retinoic acid receptor signaling pathway (GO:0048385)5.73227674
10positive regulation of histone H3-K4 methylation (GO:0051571)5.55917997
11multicellular organism reproduction (GO:0032504)5.34203801
12DNA methylation involved in gamete generation (GO:0043046)5.19201998
13phosphorelay signal transduction system (GO:0000160)5.17219528
14L-amino acid import (GO:0043092)5.17139138
15oocyte development (GO:0048599)5.08832966
16positive regulation of gastrulation (GO:2000543)4.93131515
17regulation of synapse structural plasticity (GO:0051823)4.77048908
18striatum development (GO:0021756)4.76911080
19regulation of histone H3-K9 methylation (GO:0051570)4.74896419
20synaptic vesicle maturation (GO:0016188)4.72474768
21regulation of steroid hormone secretion (GO:2000831)4.69680962
22protein kinase C signaling (GO:0070528)4.66405892
23membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.65065845
24vocalization behavior (GO:0071625)4.63507530
25regulation of short-term neuronal synaptic plasticity (GO:0048172)4.58391457
26negative regulation of reproductive process (GO:2000242)4.53970248
27locomotory exploration behavior (GO:0035641)4.47700299
28female gamete generation (GO:0007292)4.35359359
29synaptic transmission, dopaminergic (GO:0001963)4.31060052
30positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.29530019
31neuronal action potential propagation (GO:0019227)4.28204246
32synaptic vesicle exocytosis (GO:0016079)4.27425253
33regulation of cell maturation (GO:1903429)4.24178394
34prepulse inhibition (GO:0060134)4.08883559
35positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.04935557
36negative regulation of histone methylation (GO:0031061)4.04114632
37adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.01744281
38amino acid import (GO:0043090)4.00992836
39regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.92289904
40regulation of glutamate receptor signaling pathway (GO:1900449)3.91312947
41neurotransmitter secretion (GO:0007269)3.85888799
42regulation of calcium ion-dependent exocytosis (GO:0017158)3.82599173
43regulation of meiosis (GO:0040020)3.82244817
44regulation of synaptic vesicle exocytosis (GO:2000300)3.78858539
45positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.78519673
46behavioral response to cocaine (GO:0048148)3.77612789
47negative regulation of cytosolic calcium ion concentration (GO:0051481)3.74196168
48gene silencing by RNA (GO:0031047)3.67598551
49activation of protein kinase A activity (GO:0034199)3.67526247
50positive regulation of humoral immune response (GO:0002922)3.65687509
51regulation of neuronal synaptic plasticity (GO:0048168)3.64310862
52negative regulation of dendrite morphogenesis (GO:0050774)3.62675379
53regulation of long-term neuronal synaptic plasticity (GO:0048169)3.62019212
54neurotransmitter-gated ion channel clustering (GO:0072578)3.61838410
55regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.61225046
56phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.58409551
57gamma-aminobutyric acid signaling pathway (GO:0007214)3.56270393
58regulation of steroid hormone biosynthetic process (GO:0090030)3.55154835
59regulation of membrane repolarization (GO:0060306)3.54372583
60positive regulation of uterine smooth muscle contraction (GO:0070474)3.54280790
61regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.53450751
62gamma-aminobutyric acid transport (GO:0015812)3.52919875
63cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.48191156
64synaptic vesicle docking involved in exocytosis (GO:0016081)3.47750547
65glutamate secretion (GO:0014047)3.47593344
66reproduction (GO:0000003)3.47245854
67protein localization to synapse (GO:0035418)3.46572541
68regulation of synaptic vesicle transport (GO:1902803)3.44298890
69response to amphetamine (GO:0001975)3.43618702
70primitive streak formation (GO:0090009)3.41066834
71negative regulation of hormone biosynthetic process (GO:0032353)3.38986000
72exploration behavior (GO:0035640)3.38663834
73neuron-neuron synaptic transmission (GO:0007270)3.38595334
74positive regulation of reproductive process (GO:2000243)3.37225350
75centriole replication (GO:0007099)3.35619692
76neuromuscular process controlling posture (GO:0050884)3.34228592
77regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.33116148
78regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.33116148
79positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.31590999
80membrane depolarization during action potential (GO:0086010)3.29829353
81neuron cell-cell adhesion (GO:0007158)3.29450702
82positive regulation of meiosis (GO:0045836)3.29418961
83negative regulation of dendrite development (GO:2000171)3.28430430
84regulation of voltage-gated calcium channel activity (GO:1901385)3.28177620
85positive regulation of synaptic transmission, GABAergic (GO:0032230)3.27738833
86cellular potassium ion homeostasis (GO:0030007)3.27617035
87dopamine receptor signaling pathway (GO:0007212)3.27403908
88detection of calcium ion (GO:0005513)3.25004468
89regulation of female receptivity (GO:0045924)3.22520716
90negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.21925644
91regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.21895069
92stress granule assembly (GO:0034063)3.20978812
93female mating behavior (GO:0060180)3.20836424
94regulation of meiotic cell cycle (GO:0051445)3.20704736
95mitotic chromosome condensation (GO:0007076)3.20694630
96neuronal action potential (GO:0019228)3.19503365
97negative regulation of hormone metabolic process (GO:0032351)3.18379143
98cell communication by electrical coupling (GO:0010644)3.17611084
99regulation of corticosteroid hormone secretion (GO:2000846)3.16339442
100drinking behavior (GO:0042756)3.15304814
101neuromuscular process controlling balance (GO:0050885)3.14781723
102regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.11564855
103positive regulation of meiotic cell cycle (GO:0051446)3.11491461
104positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.11226745
105regulation of synaptic transmission, glutamatergic (GO:0051966)3.10820143
106long-chain fatty acid biosynthetic process (GO:0042759)3.10802246
107auditory behavior (GO:0031223)3.10746519
108cellular response to pH (GO:0071467)3.10703238
109regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.10573000
110response to auditory stimulus (GO:0010996)3.09777000
111transmission of nerve impulse (GO:0019226)3.09305906
112regulation of synaptic transmission, dopaminergic (GO:0032225)3.09254564
113neuronal ion channel clustering (GO:0045161)3.08288960
114DNA alkylation (GO:0006305)3.08245133
115DNA methylation (GO:0006306)3.08245133
116sensory perception of smell (GO:0007608)3.08156020
117regulation of protein kinase A signaling (GO:0010738)3.07971183
118positive regulation of histone methylation (GO:0031062)3.06175877
119cell communication involved in cardiac conduction (GO:0086065)3.05763694
120calcium-mediated signaling using intracellular calcium source (GO:0035584)3.05126807
121long-term memory (GO:0007616)3.04966651
122neuron fate determination (GO:0048664)3.04950857
123positive regulation of neurotransmitter transport (GO:0051590)3.04856717
124neurotransmitter transport (GO:0006836)3.03418113
125ionotropic glutamate receptor signaling pathway (GO:0035235)3.02417624
126response to acidic pH (GO:0010447)3.02358890
127long-term synaptic potentiation (GO:0060291)3.01532731
128positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.98868197
129sleep (GO:0030431)2.98669587
130regulation of glutamate secretion (GO:0014048)2.98335215
131mating behavior (GO:0007617)2.98113802
132regulation of excitatory postsynaptic membrane potential (GO:0060079)2.97351428
133regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.97018018
134regulation of histone H3-K4 methylation (GO:0051569)2.96976101
135layer formation in cerebral cortex (GO:0021819)2.95980119
136regulation of dendritic spine morphogenesis (GO:0061001)2.94664222
137synaptic transmission, glutamatergic (GO:0035249)2.93893560
138regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.92847598
139positive regulation of potassium ion transmembrane transport (GO:1901381)2.92039514
140aggressive behavior (GO:0002118)2.91982881
141regulation of neurotransmitter levels (GO:0001505)2.91953344
142pyrimidine nucleobase catabolic process (GO:0006208)2.91602001
143regulation of neurotransmitter uptake (GO:0051580)2.91566482
144regulation of sodium ion transmembrane transporter activity (GO:2000649)2.91248580
145regulation of calcium ion transmembrane transport (GO:1903169)2.90696368
146regulation of calcium ion transmembrane transporter activity (GO:1901019)2.90696368
147membrane repolarization (GO:0086009)2.90636410
148cardiac conduction (GO:0061337)2.90013150
149regulation of heart rate by cardiac conduction (GO:0086091)2.89942229
150vesicle transport along microtubule (GO:0047496)2.89610915
151G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.89496376
152positive regulation of dendritic spine morphogenesis (GO:0061003)2.88855786
153glycine transport (GO:0015816)2.88830277
154positive regulation of membrane potential (GO:0045838)2.88698669
155membrane hyperpolarization (GO:0060081)2.88668814
156regulation of synaptic plasticity (GO:0048167)2.88310770
157male meiosis I (GO:0007141)2.87903745
158negative regulation of synaptic transmission, GABAergic (GO:0032229)2.85728081
159neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.83790804
160calcium ion-dependent exocytosis (GO:0017156)2.82481597
161relaxation of smooth muscle (GO:0044557)2.82412660
162presynaptic membrane assembly (GO:0097105)2.81894283
163hyperosmotic salinity response (GO:0042538)2.78770436
164fertilization (GO:0009566)2.77181267
165pyrimidine dimer repair (GO:0006290)2.76617774
166attachment of spindle microtubules to kinetochore (GO:0008608)2.75382494
167cerebral cortex neuron differentiation (GO:0021895)2.74095759
168binding of sperm to zona pellucida (GO:0007339)2.73878773
169negative regulation of execution phase of apoptosis (GO:1900118)2.73114211
170regulation of reproductive process (GO:2000241)2.71506345
171regulation of feeding behavior (GO:0060259)2.70435211
172positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.67651591
173synapsis (GO:0007129)2.66261387
174regulation of penile erection (GO:0060405)2.64988057
175regulation of uterine smooth muscle contraction (GO:0070472)2.64961625
176male meiosis (GO:0007140)2.64199642
177single fertilization (GO:0007338)2.63401635
178citrulline biosynthetic process (GO:0019240)2.62620880
179regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.62210485
180somite rostral/caudal axis specification (GO:0032525)2.61937324
181short-term memory (GO:0007614)2.60373116
182microtubule severing (GO:0051013)2.60031794
183developmental cell growth (GO:0048588)2.59862370

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.93644633
2GBX2_23144817_ChIP-Seq_PC3_Human3.21080785
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.16877151
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.11526614
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09661564
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.94477514
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.89942087
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.86385082
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.79497470
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66930772
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66930772
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63721341
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.59702594
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53520632
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49921480
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49489477
17DROSHA_22980978_ChIP-Seq_HELA_Human2.46126032
18REST_21632747_ChIP-Seq_MESCs_Mouse2.36286915
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33308421
20TAF15_26573619_Chip-Seq_HEK293_Human2.25068682
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.20067139
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.20038009
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18566593
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.14203989
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.10450596
26KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.10450596
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.10450596
28ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.10220545
29REST_18959480_ChIP-ChIP_MESCs_Mouse2.04981410
30GATA1_26923725_Chip-Seq_HPCs_Mouse2.04490735
31EED_16625203_ChIP-ChIP_MESCs_Mouse2.04352979
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.94009367
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.85746230
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74948005
35AR_21572438_ChIP-Seq_LNCaP_Human1.73493529
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.67142680
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.63761244
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62594021
39SMAD4_21799915_ChIP-Seq_A2780_Human1.56620479
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52113029
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47445626
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45983655
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44695064
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38317626
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37467291
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35560591
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35038019
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33413317
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30743460
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28913805
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28401795
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28121801
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23568819
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.22943509
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.22525128
56MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.22426656
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22038339
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19986982
59HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19879751
60LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19533134
61P300_19829295_ChIP-Seq_ESCs_Human1.19072208
62RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17886699
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17861986
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.17071369
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15489032
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.15386132
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14472462
68CBP_20019798_ChIP-Seq_JUKART_Human1.14472462
69EP300_21415370_ChIP-Seq_HL-1_Mouse1.13490727
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12605431
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12162042
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12162042
73P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11800734
74ZNF274_21170338_ChIP-Seq_K562_Hela1.10648535
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10021709
76TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09282450
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.08070481
78AHR_22903824_ChIP-Seq_MCF-7_Human1.06734488
79STAT3_23295773_ChIP-Seq_U87_Human1.06424957
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06382727
81AR_19668381_ChIP-Seq_PC3_Human1.06248584
82AR_25329375_ChIP-Seq_VCAP_Human1.06099891
83BCAT_22108803_ChIP-Seq_LS180_Human1.04679995
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04241684
85KDM2B_26808549_Chip-Seq_K562_Human1.03649832
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02940748
87MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02937888
88EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02597251
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.02375875
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01687538
91* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01470618
92ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01417672
93TAL1_26923725_Chip-Seq_HPCs_Mouse1.01148181
94IRF1_19129219_ChIP-ChIP_H3396_Human1.00657078
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99817805
96MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98614461
97ARNT_22903824_ChIP-Seq_MCF-7_Human0.98304009
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98182190
99ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98025090
100CTCF_27219007_Chip-Seq_Bcells_Human0.97707661
101OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96298797
102SMAD4_21741376_ChIP-Seq_HESCs_Human0.95723724
103SMAD_19615063_ChIP-ChIP_OVARY_Human0.93003143
104SMAD3_21741376_ChIP-Seq_HESCs_Human0.92730378
105SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90813156
106NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90637355
107WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90393012
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89610079
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89527665
110ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89135979
111SMAD4_21741376_ChIP-Seq_EPCs_Human0.89106404
112RING1B_27294783_Chip-Seq_NPCs_Mouse0.88412108
113SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88106678
114GF1_26923725_Chip-Seq_HPCs_Mouse0.88001566
115PRDM14_20953172_ChIP-Seq_ESCs_Human0.87686227
116CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87482914
117TCF4_23295773_ChIP-Seq_U87_Human0.87337410
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87087307
119RUNX2_22187159_ChIP-Seq_PCA_Human0.86387195
120FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.85481839
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84263214
122GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83595928
123TP53_22573176_ChIP-Seq_HFKS_Human0.83237747
124ZFP281_18757296_ChIP-ChIP_E14_Mouse0.83022455
125CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.82680674
126CBX2_27304074_Chip-Seq_ESCs_Mouse0.82527089
127RNF2_27304074_Chip-Seq_NSC_Mouse0.82431656
128TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82389218
129YAP1_20516196_ChIP-Seq_MESCs_Mouse0.82280130
130IGF1R_20145208_ChIP-Seq_DFB_Human0.82088985
131SMAD3_21741376_ChIP-Seq_ESCs_Human0.81978014
132TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.81796746
133TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.81745286
134KLF4_19829295_ChIP-Seq_ESCs_Human0.81534200
135POU3F2_20337985_ChIP-ChIP_501MEL_Human0.81245661
136CBP_21632823_ChIP-Seq_H3396_Human0.80297074
137RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.79243915
138STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.78055864
139JUN_21703547_ChIP-Seq_K562_Human0.77884633

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy5.97169679
2MP0003718_maternal_effect5.89109712
3MP0004859_abnormal_synaptic_plasticity4.83922580
4MP0008877_abnormal_DNA_methylation3.89709867
5MP0006292_abnormal_olfactory_placode3.77536624
6MP0003880_abnormal_central_pattern3.73764780
7MP0008789_abnormal_olfactory_epithelium3.55991609
8MP0003635_abnormal_synaptic_transmissio3.42540987
9MP0009745_abnormal_behavioral_response3.15820868
10MP0009046_muscle_twitch3.14908757
11MP0004270_analgesia3.03819627
12MP0001984_abnormal_olfaction2.97627722
13MP0002063_abnormal_learning/memory/cond2.76518286
14MP0002064_seizures2.76273869
15MP0002735_abnormal_chemical_nociception2.72267192
16MP0002272_abnormal_nervous_system2.55799468
17MP0001486_abnormal_startle_reflex2.45035283
18MP0001968_abnormal_touch/_nociception2.43372296
19MP0002734_abnormal_mechanical_nocicepti2.36529356
20MP0003121_genomic_imprinting2.36143581
21MP0002572_abnormal_emotion/affect_behav2.33218008
22MP0003890_abnormal_embryonic-extraembry2.31706193
23MP0002837_dystrophic_cardiac_calcinosis2.28682705
24MP0005395_other_phenotype2.24746982
25MP0000751_myopathy2.18397166
26MP0002909_abnormal_adrenal_gland2.11925036
27MP0002736_abnormal_nociception_after2.05185856
28MP0002234_abnormal_pharynx_morphology2.03277642
29MP0001529_abnormal_vocalization2.02234666
30MP0001501_abnormal_sleep_pattern1.96035580
31MP0001970_abnormal_pain_threshold1.95848111
32MP0003646_muscle_fatigue1.92885269
33MP0008569_lethality_at_weaning1.84692335
34MP0005646_abnormal_pituitary_gland1.82794961
35MP0006276_abnormal_autonomic_nervous1.82002834
36MP0002733_abnormal_thermal_nociception1.76422834
37MP0002067_abnormal_sensory_capabilities1.76240855
38MP0002139_abnormal_hepatobiliary_system1.72938486
39MP0005423_abnormal_somatic_nervous1.71965566
40MP0004215_abnormal_myocardial_fiber1.68342380
41MP0010030_abnormal_orbit_morphology1.67056720
42MP0004858_abnormal_nervous_system1.66161927
43MP0005386_behavior/neurological_phenoty1.65983622
44MP0004924_abnormal_behavior1.65983622
45MP0003699_abnormal_female_reproductive1.63491997
46MP0004147_increased_porphyrin_level1.62562835
47MP0002184_abnormal_innervation1.61085534
48MP0001440_abnormal_grooming_behavior1.57022616
49MP0004036_abnormal_muscle_relaxation1.55241423
50MP0004085_abnormal_heartbeat1.53171326
51MP0003879_abnormal_hair_cell1.52221673
52MP0002557_abnormal_social/conspecific_i1.50800858
53MP0001929_abnormal_gametogenesis1.49958570
54MP0002138_abnormal_hepatobiliary_system1.47755971
55MP0004811_abnormal_neuron_physiology1.46126384
56MP0003137_abnormal_impulse_conducting1.43575692
57MP0003122_maternal_imprinting1.41852221
58MP0002210_abnormal_sex_determination1.38564466
59MP0001188_hyperpigmentation1.37886264
60MP0000631_abnormal_neuroendocrine_gland1.36520645
61MP0008057_abnormal_DNA_replication1.33337069
62MP0000566_synostosis1.33238121
63MP0003693_abnormal_embryo_hatching1.32497415
64MP0003329_amyloid_beta_deposits1.31654862
65MP0004142_abnormal_muscle_tone1.31065274
66MP0003787_abnormal_imprinting1.30872320
67MP0010234_abnormal_vibrissa_follicle1.30826482
68MP0002161_abnormal_fertility/fecundity1.27025917
69MP0000013_abnormal_adipose_tissue1.26359431
70MP0008874_decreased_physiological_sensi1.25671341
71MP0004084_abnormal_cardiac_muscle1.24981014
72MP0003633_abnormal_nervous_system1.24947874
73MP0004484_altered_response_of1.24594278
74MP0009780_abnormal_chondrocyte_physiolo1.24180213
75MP0000955_abnormal_spinal_cord1.21259289
76MP0005360_urolithiasis1.21063495
77MP0002066_abnormal_motor_capabilities/c1.20873558
78MP0001293_anophthalmia1.16096940
79MP0000749_muscle_degeneration1.15655131
80MP0002882_abnormal_neuron_morphology1.14558788
81MP0001905_abnormal_dopamine_level1.10946650
82MP0005410_abnormal_fertilization1.10066287
83MP0000653_abnormal_sex_gland1.10055593
84MP0005620_abnormal_muscle_contractility1.09985543
85MP0005167_abnormal_blood-brain_barrier1.09752555
86MP0004145_abnormal_muscle_electrophysio1.08079065
87MP0003183_abnormal_peptide_metabolism1.06825692
88MP0002160_abnormal_reproductive_system1.05562646
89MP0008872_abnormal_physiological_respon1.03258089
90MP0002229_neurodegeneration1.03204130
91MP0002972_abnormal_cardiac_muscle1.02348881
92MP0004885_abnormal_endolymph1.01877726
93MP0002233_abnormal_nose_morphology1.01171238
94MP0005330_cardiomyopathy1.00942870
95MP0005535_abnormal_body_temperature1.00909089
96MP0001485_abnormal_pinna_reflex0.99673065
97MP0008995_early_reproductive_senescence0.99296822
98MP0008058_abnormal_DNA_repair0.98466069
99MP0000427_abnormal_hair_cycle0.93767699
100MP0003075_altered_response_to0.92558613
101MP0004130_abnormal_muscle_cell0.92351693
102MP0003631_nervous_system_phenotype0.92348643
103MP0005409_darkened_coat_color0.91680559
104MP0003698_abnormal_male_reproductive0.91469891
105MP0002102_abnormal_ear_morphology0.91338067
106MP0009840_abnormal_foam_cell0.89247926
107MP0001502_abnormal_circadian_rhythm0.88362412
108MP0002638_abnormal_pupillary_reflex0.85824043
109MP0005187_abnormal_penis_morphology0.85462103
110MP0005551_abnormal_eye_electrophysiolog0.84686377
111MP0000778_abnormal_nervous_system0.84187775
112MP0005394_taste/olfaction_phenotype0.83661206
113MP0005499_abnormal_olfactory_system0.83661206
114MP0010386_abnormal_urinary_bladder0.81807281
115MP0001145_abnormal_male_reproductive0.80132552
116MP0001986_abnormal_taste_sensitivity0.80087956
117MP0003634_abnormal_glial_cell0.78838430
118MP0003119_abnormal_digestive_system0.78746164
119MP0000049_abnormal_middle_ear0.78460446
120MP0008775_abnormal_heart_ventricle0.77818873
121MP0004087_abnormal_muscle_fiber0.76494050
122MP0005385_cardiovascular_system_phenoty0.75913424
123MP0001544_abnormal_cardiovascular_syste0.75913424
124MP0001177_atelectasis0.75869343
125MP0002090_abnormal_vision0.75705326
126MP0005623_abnormal_meninges_morphology0.74985373
127MP0002069_abnormal_eating/drinking_beha0.74931083
128MP0002751_abnormal_autonomic_nervous0.72361042
129MP0000747_muscle_weakness0.71788500
130MP0005645_abnormal_hypothalamus_physiol0.71185610
131MP0002752_abnormal_somatic_nervous0.70236266
132MP0003690_abnormal_glial_cell0.70061308
133MP0001119_abnormal_female_reproductive0.69382485
134MP0001324_abnormal_eye_pigmentation0.69185548
135MP0004233_abnormal_muscle_weight0.68889686
136MP0002152_abnormal_brain_morphology0.68638084
137MP0000230_abnormal_systemic_arterial0.68522766
138MP0001664_abnormal_digestion0.68025882
139MP0006036_abnormal_mitochondrial_physio0.67451853
140MP0001963_abnormal_hearing_physiology0.65602076
141MP0006138_congestive_heart_failure0.64931017
142MP0003077_abnormal_cell_cycle0.63870127
143MP0000762_abnormal_tongue_morphology0.63259884
144MP0003861_abnormal_nervous_system0.61740569
145MP0000026_abnormal_inner_ear0.61619848
146MP0002332_abnormal_exercise_endurance0.61005548
147MP0006035_abnormal_mitochondrial_morpho0.60773960
148MP0004742_abnormal_vestibular_system0.60029693
149MP0005389_reproductive_system_phenotype0.59527257

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.29013241
2Focal motor seizures (HP:0011153)6.92118461
3Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)5.38648512
4Abnormal gallbladder physiology (HP:0012438)4.70317944
5Cholecystitis (HP:0001082)4.70317944
6Focal seizures (HP:0007359)4.68624284
7Atonic seizures (HP:0010819)4.53017816
8Apathy (HP:0000741)4.39009358
9Abdominal situs inversus (HP:0003363)4.35933284
10Abnormality of abdominal situs (HP:0011620)4.35933284
11Febrile seizures (HP:0002373)4.32848361
12Osteomalacia (HP:0002749)4.21398269
13Diminished motivation (HP:0000745)4.20699428
14Male infertility (HP:0003251)3.92399562
15Anterior segment dysgenesis (HP:0007700)3.88297628
16Prolonged QT interval (HP:0001657)3.81342925
17Septo-optic dysplasia (HP:0100842)3.77132927
18Absence seizures (HP:0002121)3.74040738
19Supernumerary spleens (HP:0009799)3.72315555
20Impulsivity (HP:0100710)3.71769646
21Visual hallucinations (HP:0002367)3.62085116
22Action tremor (HP:0002345)3.61045886
23Abnormality of the labia minora (HP:0012880)3.57299515
24Ventricular fibrillation (HP:0001663)3.51635791
25Hypophosphatemic rickets (HP:0004912)3.50005115
26Papillary thyroid carcinoma (HP:0002895)3.37425680
27Annular pancreas (HP:0001734)3.36903750
28Epileptic encephalopathy (HP:0200134)3.36634903
29Generalized tonic-clonic seizures (HP:0002069)3.32459369
30Atrial fibrillation (HP:0005110)3.31019432
31Lip pit (HP:0100267)3.30301285
32Sudden death (HP:0001699)3.30252092
33Hypoplasia of the fovea (HP:0007750)3.28411379
34Aplasia/Hypoplasia of the fovea (HP:0008060)3.28411379
35Anxiety (HP:0000739)3.28379374
36Dialeptic seizures (HP:0011146)3.23908217
37Absent septum pellucidum (HP:0001331)3.21469659
38Primary atrial arrhythmia (HP:0001692)3.18345740
39Torticollis (HP:0000473)3.17597300
40Pheochromocytoma (HP:0002666)3.17165117
41Oligodactyly (hands) (HP:0001180)3.17031704
42Progressive inability to walk (HP:0002505)3.13173825
43Infertility (HP:0000789)3.12866497
44Abnormal EKG (HP:0003115)3.08145442
45Supraventricular tachycardia (HP:0004755)3.03153136
46Ankle clonus (HP:0011448)3.00871281
47Atrioventricular block (HP:0001678)2.99822838
48Depression (HP:0000716)2.99560456
49Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.98980903
50Syncope (HP:0001279)2.98680538
51Supraventricular arrhythmia (HP:0005115)2.94277346
52Abnormality of the fovea (HP:0000493)2.93871828
53Hypokinesia (HP:0002375)2.90425171
54Facial hemangioma (HP:0000329)2.89307635
55Progressive cerebellar ataxia (HP:0002073)2.87026476
56Impaired social interactions (HP:0000735)2.83663413
57Abnormal social behavior (HP:0012433)2.83663413
58Heart block (HP:0012722)2.83655309
59Neuroendocrine neoplasm (HP:0100634)2.83380528
60Resting tremor (HP:0002322)2.81841900
61Bundle branch block (HP:0011710)2.78610186
62Craniofacial dystonia (HP:0012179)2.77669973
63Focal dystonia (HP:0004373)2.77660983
64Supranuclear gaze palsy (HP:0000605)2.76537140
65Exercise-induced myalgia (HP:0003738)2.75465255
66Poor eye contact (HP:0000817)2.69590107
67Short tibia (HP:0005736)2.66736519
68Abnormality of the septum pellucidum (HP:0007375)2.61683274
69Gaze-evoked nystagmus (HP:0000640)2.61225357
70Dysdiadochokinesis (HP:0002075)2.60499108
71Abnormal atrioventricular conduction (HP:0005150)2.58840310
72Impaired vibration sensation in the lower limbs (HP:0002166)2.56491492
73Palpitations (HP:0001962)2.55391703
74Hyperventilation (HP:0002883)2.51781236
75Truncal obesity (HP:0001956)2.49233669
76Postural instability (HP:0002172)2.48155753
77Abnormal respiratory motile cilium physiology (HP:0012261)2.46029624
78Truncal ataxia (HP:0002078)2.44509710
79Muscle stiffness (HP:0003552)2.43457753
80Dysmetric saccades (HP:0000641)2.43096374
81Myotonia (HP:0002486)2.41306248
82Abnormal ciliary motility (HP:0012262)2.40375577
83Malnutrition (HP:0004395)2.39886694
84Abnormal mitochondria in muscle tissue (HP:0008316)2.39871714
85Abnormal eating behavior (HP:0100738)2.38215884
86Broad-based gait (HP:0002136)2.37985320
87Scanning speech (HP:0002168)2.37636082
88Aplasia/Hypoplasia of the tibia (HP:0005772)2.37335792
89Acute necrotizing encephalopathy (HP:0006965)2.35929714
90Peripheral hypomyelination (HP:0007182)2.34664414
91Gonadotropin excess (HP:0000837)2.34034864
92Hypercortisolism (HP:0001578)2.32607998
93Central scotoma (HP:0000603)2.32225644
94Calf muscle hypertrophy (HP:0008981)2.30005008
95Urinary bladder sphincter dysfunction (HP:0002839)2.28601562
96Limb dystonia (HP:0002451)2.27747445
97Median cleft lip (HP:0000161)2.27670369
98Urinary urgency (HP:0000012)2.26159200
99Abnormality of pain sensation (HP:0010832)2.21580141
100Impaired pain sensation (HP:0007328)2.21580141
101Oligodactyly (HP:0012165)2.19819621
102Progressive macrocephaly (HP:0004481)2.19076301
103Neurofibrillary tangles (HP:0002185)2.18956063
104Spinal cord compression (HP:0002176)2.17256884
105Neoplasm of the peripheral nervous system (HP:0100007)2.15827443
106Striae distensae (HP:0001065)2.14893148
107Dysmetria (HP:0001310)2.14850791
108Azoospermia (HP:0000027)2.11699980
109Amblyopia (HP:0000646)2.11291458
110Abnormality of calcium-phosphate metabolism (HP:0100530)2.10235824
111Bradykinesia (HP:0002067)2.10002022
112Abnormality of the corticospinal tract (HP:0002492)2.09277778
113Premature ovarian failure (HP:0008209)2.08973664
114Rhinitis (HP:0012384)2.08040983
115Muscle hypertrophy of the lower extremities (HP:0008968)2.07950748
116Exercise-induced muscle cramps (HP:0003710)2.07255917
117Wrist flexion contracture (HP:0001239)2.06854384
118Left ventricular hypertrophy (HP:0001712)2.05990778
119Mutism (HP:0002300)2.05641443
120Aplasia of the musculature (HP:0100854)2.04153463
121Abnormality of the calf musculature (HP:0001430)2.03599669
122Inability to walk (HP:0002540)2.02717792
123Status epilepticus (HP:0002133)2.02660909
124Bradycardia (HP:0001662)2.02247009
125Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.00512415
126Foot dorsiflexor weakness (HP:0009027)2.00382366
127Esotropia (HP:0000565)2.00053285
128Ventricular arrhythmia (HP:0004308)1.99809987
129Proximal tubulopathy (HP:0000114)1.98483266
130Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.98439613
131Acute encephalopathy (HP:0006846)1.97698577
132Polyphagia (HP:0002591)1.95783610
133Broad alveolar ridges (HP:0000187)1.94472466
134Spastic gait (HP:0002064)1.93631228
135Hemiplegia (HP:0002301)1.93338718
136Stereotypic behavior (HP:0000733)1.92788380
137Optic nerve hypoplasia (HP:0000609)1.92656089
138Diminished movement (HP:0002374)1.92446572
139Ulnar claw (HP:0001178)1.90382003
140Increased circulating renin level (HP:0000848)1.90261735
141Aplasia/Hypoplasia of the macula (HP:0008059)1.88440831
142Gait imbalance (HP:0002141)1.88238236
143Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.87131228
144Thyroid carcinoma (HP:0002890)1.86719070
145Lower limb amyotrophy (HP:0007210)1.85762443
146Insidious onset (HP:0003587)1.84172299
147Termporal pattern (HP:0011008)1.84172299
148Generalized aminoaciduria (HP:0002909)1.84152585
149Abnormality of the foot musculature (HP:0001436)1.83568602
150Drooling (HP:0002307)1.83140596
151Abnormal respiratory epithelium morphology (HP:0012253)1.83058481
152Abnormal respiratory motile cilium morphology (HP:0005938)1.83058481
153Rapidly progressive (HP:0003678)1.83035053
154Aplasia/Hypoplasia of the tongue (HP:0010295)1.82670439
155Intention tremor (HP:0002080)1.82603400
156Skin pits (HP:0100276)1.82492980
157Heterotopia (HP:0002282)1.82365492
158Mitochondrial inheritance (HP:0001427)1.81901418
159Spinal canal stenosis (HP:0003416)1.81295259
160Retinal dysplasia (HP:0007973)1.80641411
161Abnormality of the labia (HP:0000058)1.80501929
162Fetal akinesia sequence (HP:0001989)1.79837879
163Hepatocellular necrosis (HP:0001404)1.74922541
164Lower limb muscle weakness (HP:0007340)1.73888366
165Intrahepatic cholestasis (HP:0001406)1.73887710
166Generalized myoclonic seizures (HP:0002123)1.73333552
167Hand muscle atrophy (HP:0009130)1.73240631
168Aplasia/Hypoplasia affecting the retina (HP:0008061)1.72318740
169Sensory axonal neuropathy (HP:0003390)1.70876058
170Hypohidrosis (HP:0000966)1.70742083
171Postural tremor (HP:0002174)1.70172969
172Adrenal overactivity (HP:0002717)1.69740407
173Neuronal loss in central nervous system (HP:0002529)1.69263407
174Medial flaring of the eyebrow (HP:0010747)1.68797522
175Epileptiform EEG discharges (HP:0011182)1.67583878

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.63793326
2NTRK34.32418587
3NEK63.02997479
4MINK12.91524393
5LMTK22.72940190
6MAP3K92.62276319
7TRIM282.59161202
8MAP3K42.46575412
9MAP2K72.25404520
10STK242.17163235
11PHKG12.13179325
12PHKG22.13179325
13MAP3K122.12949397
14KSR22.09657747
15EPHA32.04625930
16TAOK32.03091198
17CAMKK12.02508192
18NTRK11.97321262
19BRAF1.92108304
20PINK11.85968637
21ARAF1.78685370
22CAMKK21.77328969
23DAPK21.76866442
24PRKD31.75965260
25MAP2K41.73529392
26AURKA1.72788728
27MUSK1.72458432
28MOS1.66842228
29FES1.56168318
30PAK61.54339102
31MYLK1.50880855
32RIPK41.44923476
33NEK11.43336939
34PRKCI1.41402401
35TNIK1.32267766
36CASK1.30044126
37CDK51.29729799
38TTK1.29243662
39CDK91.28746580
40CSNK1G21.20259045
41NTRK21.19180243
42MET1.18943101
43STK381.18435113
44SIK21.16856297
45CSNK1G11.16750162
46CSNK1G31.16619455
47SGK4941.16485389
48SGK2231.16485389
49MARK11.16197575
50GRK71.16022390
51GRK51.14064179
52SGK21.13626654
53MAP4K21.08318646
54WNK11.08088186
55DAPK11.07437553
56PRKCH1.07132778
57PDK31.06854036
58PDK41.06854036
59CSNK1A1L1.05538009
60PRKCG1.02891227
61KSR11.02225516
62MAP3K20.94416895
63SGK30.92946885
64BRSK10.92491338
65TAOK10.92423804
66SRPK10.91328691
67CAMK2A0.91137975
68CAMK2D0.89665053
69PLK10.88949196
70MAPK130.88899683
71TNK20.87660144
72EIF2AK30.87022093
73CAMK10.86326255
74SIK30.85420944
75RET0.81651944
76CAMK2G0.79592118
77BCR0.79510629
78MAP3K130.79339714
79PDPK10.78477242
80TIE10.76928935
81DYRK20.76867869
82PRPF4B0.76412325
83RIPK10.76399032
84PTK2B0.75527642
85NEK20.74984527
86RAF10.72327625
87CDK190.72112463
88MAP3K50.71774792
89PRKCE0.70306014
90PRKCZ0.69744885
91CDK70.69571669
92MAPKAPK30.69462901
93CDK11A0.69106964
94PDK10.68786099
95PKN10.67772582
96CSNK1E0.67270381
97CSNK1D0.66776983
98CAMK2B0.66269109
99MAP3K10.65738079
100MAP2K10.65699574
101CDK120.64794805
102TTN0.64667614
103PAK30.64096761
104WNK30.61527315
105PRKG10.61261552
106TYRO30.60792232
107UHMK10.60573386
108CDC70.58955127
109PLK20.58858209
110RPS6KA20.58520499
111LATS20.58456270
112PDK20.57725706
113SCYL20.56635228
114OXSR10.56592915
115TRIB30.55396670
116PTK20.55068021
117CDK140.54066324
118CDK20.53525068
119BMPR20.52571232
120DMPK0.52226840
121DAPK30.51560632
122ROCK10.51551882
123STK110.51456064
124PRKG20.51042686
125CAMK40.50908438
126CDK180.50743610
127MAPK150.49924630
128MARK20.48869013
129ROCK20.47820066
130SGK10.47398414
131FER0.46643882
132PRKACA0.46010105
133CDK150.45463027
134RPS6KA30.45258227
135PNCK0.45098195
136PRKAA10.44983226
137CDK80.44220830
138MELK0.43649380
139CDC42BPA0.43572816
140PAK10.42442478
141ADRBK10.41844608
142PRKACG0.41830576
143CHEK10.41091929
144STK390.39749606
145MAPK100.39189476
146PIM10.39100849
147PLK30.38480909
148CDK10.37240765
149STK30.36683586
150DYRK1A0.34354427
151GSK3B0.34290420
152TESK20.34049429
153PRKACB0.30390794
154AKT20.29513981

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.95914663
2Basal transcription factors_Homo sapiens_hsa030223.45141416
3Synaptic vesicle cycle_Homo sapiens_hsa047212.98439364
4GABAergic synapse_Homo sapiens_hsa047272.58477300
5Nicotine addiction_Homo sapiens_hsa050332.57342489
6Morphine addiction_Homo sapiens_hsa050322.45179161
7Circadian entrainment_Homo sapiens_hsa047132.37542523
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.20988205
9Cell cycle_Homo sapiens_hsa041102.17696595
10Amphetamine addiction_Homo sapiens_hsa050312.08237428
11Dopaminergic synapse_Homo sapiens_hsa047282.07374513
12Caffeine metabolism_Homo sapiens_hsa002321.98508456
13Glutamatergic synapse_Homo sapiens_hsa047241.97697964
14Long-term potentiation_Homo sapiens_hsa047201.90789035
15Cardiac muscle contraction_Homo sapiens_hsa042601.87507920
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.85509741
17Cholinergic synapse_Homo sapiens_hsa047251.83449490
18Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.81294473
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.78887068
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.78623077
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78551925
22Salivary secretion_Homo sapiens_hsa049701.78348929
23Gastric acid secretion_Homo sapiens_hsa049711.74770268
24Insulin secretion_Homo sapiens_hsa049111.71308924
25Renin secretion_Homo sapiens_hsa049241.69520942
26Cocaine addiction_Homo sapiens_hsa050301.68981711
27Taste transduction_Homo sapiens_hsa047421.68113921
28Calcium signaling pathway_Homo sapiens_hsa040201.63878432
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.63397729
30Parkinsons disease_Homo sapiens_hsa050121.61454806
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57757237
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.55219431
33RNA degradation_Homo sapiens_hsa030181.51083654
34Collecting duct acid secretion_Homo sapiens_hsa049661.50453999
35Oxytocin signaling pathway_Homo sapiens_hsa049211.50412510
36Oxidative phosphorylation_Homo sapiens_hsa001901.44406056
37Base excision repair_Homo sapiens_hsa034101.38712051
38Serotonergic synapse_Homo sapiens_hsa047261.36772731
39Nitrogen metabolism_Homo sapiens_hsa009101.33716185
40cAMP signaling pathway_Homo sapiens_hsa040241.25766995
41Dilated cardiomyopathy_Homo sapiens_hsa054141.24767048
42Gap junction_Homo sapiens_hsa045401.23311981
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23220164
44GnRH signaling pathway_Homo sapiens_hsa049121.19530303
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19371970
46Alzheimers disease_Homo sapiens_hsa050101.18734843
47Mismatch repair_Homo sapiens_hsa034301.13310466
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.12960594
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11283829
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.10512165
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09393332
52Phototransduction_Homo sapiens_hsa047441.06137655
53cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05450588
54Vascular smooth muscle contraction_Homo sapiens_hsa042701.02931482
55Long-term depression_Homo sapiens_hsa047301.02844621
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02481647
57p53 signaling pathway_Homo sapiens_hsa041151.02215291
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94712629
59Butanoate metabolism_Homo sapiens_hsa006500.94451689
60mRNA surveillance pathway_Homo sapiens_hsa030150.91095510
61Vibrio cholerae infection_Homo sapiens_hsa051100.90908566
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85351331
63Folate biosynthesis_Homo sapiens_hsa007900.84549873
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83382112
65Huntingtons disease_Homo sapiens_hsa050160.83098643
66Estrogen signaling pathway_Homo sapiens_hsa049150.80395392
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79473248
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78875851
69Glioma_Homo sapiens_hsa052140.76541373
70Fatty acid elongation_Homo sapiens_hsa000620.75346515
71Melanogenesis_Homo sapiens_hsa049160.74861713
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74666555
73Glucagon signaling pathway_Homo sapiens_hsa049220.73899623
74Bile secretion_Homo sapiens_hsa049760.73680113
75Pyruvate metabolism_Homo sapiens_hsa006200.69968565
76Type II diabetes mellitus_Homo sapiens_hsa049300.69887829
77Regulation of autophagy_Homo sapiens_hsa041400.68749440
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67553770
79Steroid biosynthesis_Homo sapiens_hsa001000.66633511
80Arginine and proline metabolism_Homo sapiens_hsa003300.66174673
81ABC transporters_Homo sapiens_hsa020100.64009899
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63136988
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62321031
84RNA transport_Homo sapiens_hsa030130.61128704
85Thyroid hormone synthesis_Homo sapiens_hsa049180.60967444
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59343129
87Pancreatic secretion_Homo sapiens_hsa049720.59180177
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.58404015
89Nucleotide excision repair_Homo sapiens_hsa034200.57414704
90Propanoate metabolism_Homo sapiens_hsa006400.57224359
91Rap1 signaling pathway_Homo sapiens_hsa040150.56640610
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56331441
93ErbB signaling pathway_Homo sapiens_hsa040120.56273700
94Arginine biosynthesis_Homo sapiens_hsa002200.55466415
95Dorso-ventral axis formation_Homo sapiens_hsa043200.54029984
96Oocyte meiosis_Homo sapiens_hsa041140.52944298
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50327723
98Insulin signaling pathway_Homo sapiens_hsa049100.50037224
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.50024112
100Type I diabetes mellitus_Homo sapiens_hsa049400.49197546
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47768999
102Fanconi anemia pathway_Homo sapiens_hsa034600.47136130
103MAPK signaling pathway_Homo sapiens_hsa040100.45629995
104Alcoholism_Homo sapiens_hsa050340.45629718
105Axon guidance_Homo sapiens_hsa043600.45362636
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43554552
107Ras signaling pathway_Homo sapiens_hsa040140.43513819
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43020492
109Hippo signaling pathway_Homo sapiens_hsa043900.42995977
110Ovarian steroidogenesis_Homo sapiens_hsa049130.42905446
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38026659
112mTOR signaling pathway_Homo sapiens_hsa041500.36478338
113Carbon metabolism_Homo sapiens_hsa012000.35776006
114RNA polymerase_Homo sapiens_hsa030200.35393983
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33636123
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32352222
117Inositol phosphate metabolism_Homo sapiens_hsa005620.32304534
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.31822187
119Wnt signaling pathway_Homo sapiens_hsa043100.31570806
120VEGF signaling pathway_Homo sapiens_hsa043700.31492973
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31248100
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.30540014
123Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30406927
124Prion diseases_Homo sapiens_hsa050200.30253400
125Endocytosis_Homo sapiens_hsa041440.30073203
126Circadian rhythm_Homo sapiens_hsa047100.30059956
127Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29547030
128Choline metabolism in cancer_Homo sapiens_hsa052310.28131775
129Non-small cell lung cancer_Homo sapiens_hsa052230.27259947
130Ether lipid metabolism_Homo sapiens_hsa005650.27257259
131Phagosome_Homo sapiens_hsa041450.22917383
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22813289

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