PCSK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endocrine pancreas development (GO:0031018)7.30822639
2protein maturation by protein folding (GO:0022417)7.29568506
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.19154432
4retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.38888366
5COPII vesicle coating (GO:0048208)6.13948285
6protein retention in ER lumen (GO:0006621)6.09707960
7regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.96687509
8regulation of type B pancreatic cell apoptotic process (GO:2000674)5.70479564
9glandular epithelial cell differentiation (GO:0002067)5.64136931
10activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.52953203
11* peptide hormone processing (GO:0016486)5.44628432
12signal peptide processing (GO:0006465)5.42443733
13insulin secretion (GO:0030073)5.38591433
14sequestering of metal ion (GO:0051238)5.29767792
15positive regulation of nuclease activity (GO:0032075)5.28159329
16type B pancreatic cell development (GO:0003323)5.27985866
17ER overload response (GO:0006983)5.21710759
18exocrine pancreas development (GO:0031017)5.17030948
19glandular epithelial cell development (GO:0002068)4.96559738
20positive regulation of insulin secretion (GO:0032024)4.88626090
21vesicle coating (GO:0006901)4.88491480
22negative regulation of hormone biosynthetic process (GO:0032353)4.84200860
23regulation of nuclease activity (GO:0032069)4.81617401
24negative regulation of gluconeogenesis (GO:0045721)4.78937061
25synaptic vesicle docking involved in exocytosis (GO:0016081)4.73140331
26endoplasmic reticulum unfolded protein response (GO:0030968)4.63143694
27* regulation of insulin secretion (GO:0050796)4.61702381
28cellular response to unfolded protein (GO:0034620)4.52776882
29ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.40165670
30cellular response to topologically incorrect protein (GO:0035967)4.39386467
31ER-nucleus signaling pathway (GO:0006984)4.38085382
32negative regulation of hormone metabolic process (GO:0032351)4.31506547
33detection of calcium ion (GO:0005513)4.23941642
34intra-Golgi vesicle-mediated transport (GO:0006891)4.23460012
35* regulation of peptide hormone secretion (GO:0090276)4.21079856
36negative regulation of norepinephrine secretion (GO:0010700)4.20269950
37dendritic spine morphogenesis (GO:0060997)4.17066842
38negative regulation of catecholamine secretion (GO:0033604)4.16362397
39synaptic vesicle maturation (GO:0016188)4.14153338
40* regulation of peptide secretion (GO:0002791)4.13879331
41nitric oxide mediated signal transduction (GO:0007263)4.11593649
42negative regulation of insulin secretion (GO:0046676)4.11165326
43negative regulation of glycoprotein biosynthetic process (GO:0010561)3.99146929
44regulation of short-term neuronal synaptic plasticity (GO:0048172)3.98587780
45positive regulation of peptide hormone secretion (GO:0090277)3.97324253
46columnar/cuboidal epithelial cell development (GO:0002066)3.92741206
47peptide hormone secretion (GO:0030072)3.92280217
48toxin metabolic process (GO:0009404)3.85672783
49positive regulation of peptide secretion (GO:0002793)3.85563257
50peptide secretion (GO:0002790)3.83693152
51positive regulation of respiratory burst (GO:0060267)3.78825694
52protein N-linked glycosylation via asparagine (GO:0018279)3.78624173
53positive regulation of growth hormone secretion (GO:0060124)3.77829613
54response to endoplasmic reticulum stress (GO:0034976)3.77239660
55negative regulation of protein oligomerization (GO:0032460)3.76126516
56peptidyl-asparagine modification (GO:0018196)3.75914296
57response to dietary excess (GO:0002021)3.73814191
58positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.73132137
59cellular response to vitamin D (GO:0071305)3.69683969
60negative regulation of acute inflammatory response (GO:0002674)3.67318975
61* regulation of hormone secretion (GO:0046883)3.64925286
62ER to Golgi vesicle-mediated transport (GO:0006888)3.64908453
63negative regulation of peptide hormone secretion (GO:0090278)3.61320198
64protein localization to Golgi apparatus (GO:0034067)3.59686902
65negative regulation of glycogen metabolic process (GO:0070874)3.59427826
66response to unfolded protein (GO:0006986)3.57313545
67positive regulation of neurotransmitter transport (GO:0051590)3.49855820
68negative regulation of peptide secretion (GO:0002792)3.48167011
69response to topologically incorrect protein (GO:0035966)3.46747136
70protein N-linked glycosylation (GO:0006487)3.45706771
71cerebellar Purkinje cell layer development (GO:0021680)3.44078261
72negative regulation of cytosolic calcium ion concentration (GO:0051481)3.41726715
73cellular zinc ion homeostasis (GO:0006882)3.41637298
74response to lipoprotein particle (GO:0055094)3.40405147
75fatty acid homeostasis (GO:0055089)3.39745888
76* regulation of peptide transport (GO:0090087)3.38561823
77astrocyte differentiation (GO:0048708)3.37555686
78macroautophagy (GO:0016236)3.36733413
79regulation of glucocorticoid secretion (GO:2000849)3.34987661
80negative regulation of bone resorption (GO:0045779)3.34813104
81regulation of feeding behavior (GO:0060259)3.33984606
82protein targeting to Golgi (GO:0000042)3.32230322
83cellular response to glucagon stimulus (GO:0071377)3.31626606
84urinary tract smooth muscle contraction (GO:0014848)3.30834735
85positive regulation of glycogen biosynthetic process (GO:0045725)3.24373735
86Golgi organization (GO:0007030)3.23637107
87response to hexose (GO:0009746)3.22628713
88regulation of glucocorticoid metabolic process (GO:0031943)3.20368945
89neurotransmitter secretion (GO:0007269)3.19883480
90glutamate secretion (GO:0014047)3.19789496
91response to glucose (GO:0009749)3.18845386
92proline transport (GO:0015824)3.17905275
93positive regulation of hormone secretion (GO:0046887)3.15168214
94inositol phosphate catabolic process (GO:0071545)3.15048357
95cAMP-mediated signaling (GO:0019933)3.11768437
96epithelial cell fate commitment (GO:0072148)3.10606127
97glycerophospholipid catabolic process (GO:0046475)3.10409957
98inner ear receptor cell development (GO:0060119)3.08961873
99cellular ketone body metabolic process (GO:0046950)3.06843932
100hormone secretion (GO:0046879)3.06554355
101response to monosaccharide (GO:0034284)3.06127958
102positive regulation of glycolytic process (GO:0045821)3.04237287
103L-alpha-amino acid transmembrane transport (GO:1902475)3.03677998
104peptide transport (GO:0015833)3.03599909
105calcium ion import (GO:0070509)3.01308736
106Golgi vesicle transport (GO:0048193)2.96775712
107hormone transport (GO:0009914)2.96605760
108chemosensory behavior (GO:0007635)2.96429067
109regulation of glucokinase activity (GO:0033131)2.94856892
110regulation of hexokinase activity (GO:1903299)2.94856892
111establishment of protein localization to Golgi (GO:0072600)2.94545325
112negative regulation of glycoprotein metabolic process (GO:1903019)2.94360500
113positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.94094400
114cellular response to hepatocyte growth factor stimulus (GO:0035729)2.94051758
115response to hepatocyte growth factor (GO:0035728)2.94051758
116nucleoside diphosphate catabolic process (GO:0009134)2.93957800
117positive regulation of exocytosis (GO:0045921)2.92307838
118regulation of growth hormone secretion (GO:0060123)2.91867588
119negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.90166695
120carbohydrate homeostasis (GO:0033500)2.89163067
121glucose homeostasis (GO:0042593)2.89163067
122lactate metabolic process (GO:0006089)2.88506475
123membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.87315383
124adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.86254111
125positive regulation of glycogen metabolic process (GO:0070875)2.85332580
126positive regulation of neurotransmitter secretion (GO:0001956)2.85125700
127regulation of steroid hormone biosynthetic process (GO:0090030)2.84924555
128retrograde transport, vesicle recycling within Golgi (GO:0000301)2.84855950
129positive regulation of insulin receptor signaling pathway (GO:0046628)2.84713306
130regulation of calcium ion-dependent exocytosis (GO:0017158)2.83415590
131regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.83066159
132regulation of oxidative phosphorylation (GO:0002082)2.82285707
133purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.82039364
1343-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.82039364
135righting reflex (GO:0060013)2.80962449
136regulation of glycolytic process (GO:0006110)2.80768268
137regulation of synaptic vesicle exocytosis (GO:2000300)2.80544564
138signal release (GO:0023061)2.80360443
139axonal fasciculation (GO:0007413)2.75405734
140positive regulation of nitric-oxide synthase activity (GO:0051000)2.75193163
141positive regulation of macroautophagy (GO:0016239)2.74554927
142cellular potassium ion homeostasis (GO:0030007)2.74100220
143positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.70605521
144calcium ion-dependent exocytosis (GO:0017156)2.70283159
145startle response (GO:0001964)2.68649268
146ketone body metabolic process (GO:1902224)2.68044078
147phosphorylated carbohydrate dephosphorylation (GO:0046838)2.66801130
148inositol phosphate dephosphorylation (GO:0046855)2.66801130
149protein localization to cilium (GO:0061512)2.65222890
150negative regulation of neurological system process (GO:0031645)2.64149945
151regulation of synaptic vesicle transport (GO:1902803)2.62207759
152dendritic spine organization (GO:0097061)2.61872712
153presynaptic membrane assembly (GO:0097105)2.60405946
154regulation of energy homeostasis (GO:2000505)2.58702137
155regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.56949460
156COPI coating of Golgi vesicle (GO:0048205)10.5216939
157Golgi transport vesicle coating (GO:0048200)10.5216939

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse9.19921526
2GATA1_22025678_ChIP-Seq_K562_Human3.95227008
3DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.74306762
4PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.55507535
5IGF1R_20145208_ChIP-Seq_DFB_Human2.46086510
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.33128718
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.32139565
8NR3C1_23031785_ChIP-Seq_PC12_Mouse2.26524377
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.93877316
10CDX2_19796622_ChIP-Seq_MESCs_Mouse1.92178952
11* REST_18959480_ChIP-ChIP_MESCs_Mouse1.89096932
12PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.87446747
13SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83437010
14GBX2_23144817_ChIP-Seq_PC3_Human1.83061302
15CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.82497117
16CBX2_27304074_Chip-Seq_ESCs_Mouse1.81413861
17ZNF274_21170338_ChIP-Seq_K562_Hela1.80697070
18EZH2_22144423_ChIP-Seq_EOC_Human1.79433522
19JARID2_20064375_ChIP-Seq_MESCs_Mouse1.73989611
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.70558550
21REST_19997604_ChIP-ChIP_NEURONS_Mouse1.70014308
22P300_19829295_ChIP-Seq_ESCs_Human1.69600961
23* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.63690375
24MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.62176528
25* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60307824
26OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.58157457
27TAF15_26573619_Chip-Seq_HEK293_Human1.57901910
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56493354
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54845847
30* EED_16625203_ChIP-ChIP_MESCs_Mouse1.54735612
31FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.52065835
32STAT3_23295773_ChIP-Seq_U87_Human1.49406024
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.48801139
34SOX2_27498859_Chip-Seq_STOMACH_Mouse1.47123292
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46650379
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.45495914
37* AR_25329375_ChIP-Seq_VCAP_Human1.45456316
38* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45185736
39SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43655170
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43384272
41RARB_27405468_Chip-Seq_BRAIN_Mouse1.39304279
42BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.39031915
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.38962032
44SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.38218047
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37029997
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36057376
47FUS_26573619_Chip-Seq_HEK293_Human1.36042827
48RNF2_27304074_Chip-Seq_NSC_Mouse1.35878866
49CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.35035018
50AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.32474025
51ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31747034
52VDR_22108803_ChIP-Seq_LS180_Human1.31642925
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31058074
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27074474
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26624608
56FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.25553792
57EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23859183
58PKCTHETA_26484144_Chip-Seq_BREAST_Human1.22656905
59CBP_20019798_ChIP-Seq_JUKART_Human1.22508201
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22508201
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.20240166
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20125101
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19688840
64P53_22387025_ChIP-Seq_ESCs_Mouse1.19628726
65* SMAD4_21799915_ChIP-Seq_A2780_Human1.19492606
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18956733
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17493991
68FOXA1_25552417_ChIP-Seq_VCAP_Human1.16819766
69ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16508948
70SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16468411
71YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15484630
72CMYC_18555785_Chip-Seq_ESCs_Mouse1.15200605
73TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14278643
74TP53_22573176_ChIP-Seq_HFKS_Human1.13366729
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.13171958
76TFEB_21752829_ChIP-Seq_HELA_Human1.13100810
77* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12947255
78CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.12857085
79EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12668380
80RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12668380
81ER_23166858_ChIP-Seq_MCF-7_Human1.10554857
82LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09992599
83DROSHA_22980978_ChIP-Seq_HELA_Human1.09905591
84ERG_20517297_ChIP-Seq_VCAP_Human1.08829243
85* HTT_18923047_ChIP-ChIP_STHdh_Human1.08554147
86* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.08426680
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07980679
88RING1B_27294783_Chip-Seq_ESCs_Mouse1.07388699
89* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07133996
90* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07107374
91WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06449585
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06160726
93MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05979309
94CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05142679
95GATA1_19941826_ChIP-Seq_K562_Human1.04833057
96RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04581501
97BCAT_22108803_ChIP-Seq_LS180_Human1.04433004
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.03910929
99CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03596126
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.03476427
101DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03207290
102* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03083565
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03049585
104* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03038320
105SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02586052
106* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01896845
107* FLI1_21867929_ChIP-Seq_TH2_Mouse1.00863316
108SMAD3_21741376_ChIP-Seq_ESCs_Human1.00287893
109* PIAS1_25552417_ChIP-Seq_VCAP_Human1.00022138
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99862671
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99862671
112ESR1_21235772_ChIP-Seq_MCF-7_Human0.99469429
113* TCF4_23295773_ChIP-Seq_U87_Human0.98807020
114TAL1_26923725_Chip-Seq_HPCs_Mouse0.98575491
115MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98380272
116PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97950396
117NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97768927
118PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97748291
119SOX2_18555785_Chip-Seq_ESCs_Mouse0.97135359
120STAT3_18555785_Chip-Seq_ESCs_Mouse0.96911838
121SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.96556814
122EZH2_27294783_Chip-Seq_ESCs_Mouse0.96440344
123STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95681198
124CTCF_18555785_Chip-Seq_ESCs_Mouse0.95551054
125EZH2_27294783_Chip-Seq_NPCs_Mouse0.95494071
126EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95005269
127FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94357943
128TDRD3_21172665_ChIP-Seq_MCF-7_Human0.91605256
129STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91147807
130BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89794189
131RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89714985
132FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.89478638
133FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.88900522
134PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88289661
135WT1_19549856_ChIP-ChIP_CCG9911_Human0.87757232
136BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.87170481
137TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87080923
138TET1_21490601_ChIP-Seq_MESCs_Mouse0.86681648
139TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85815053
140* AR_19668381_ChIP-Seq_PC3_Human0.85508767
141SUZ12_27294783_Chip-Seq_ESCs_Mouse0.84672436
142CLOCK_20551151_ChIP-Seq_293T_Human0.84203188
143NANOG_18555785_Chip-Seq_ESCs_Mouse0.84185543
144ETV2_25802403_ChIP-Seq_MESCs_Mouse0.83552717
145JARID2_20075857_ChIP-Seq_MESCs_Mouse0.82630964
146EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.81582641
147GF1B_26923725_Chip-Seq_HPCs_Mouse0.80744364
148GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.79305275
149FOXA1_27270436_Chip-Seq_PROSTATE_Human0.77703361
150FOXA1_25329375_ChIP-Seq_VCAP_Human0.77703361
151RUNX2_22187159_ChIP-Seq_PCA_Human0.77690935
152VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.77076788
153ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.76641032
154FOXA1_21572438_ChIP-Seq_LNCaP_Human0.75788821

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog5.64087267
2MP0003283_abnormal_digestive_organ5.15654133
3MP0009780_abnormal_chondrocyte_physiolo4.63977881
4MP0002909_abnormal_adrenal_gland4.60618125
5MP0002693_abnormal_pancreas_physiology4.41034195
6MP0004043_abnormal_pH_regulation4.10516449
7MP0001944_abnormal_pancreas_morphology3.87744479
8MP0002822_catalepsy3.70024011
9MP0000013_abnormal_adipose_tissue3.61427512
10MP0003195_calcinosis3.44658086
11MP0010386_abnormal_urinary_bladder3.25295881
12MP0000678_abnormal_parathyroid_gland3.20037923
13MP0005379_endocrine/exocrine_gland_phen3.18565158
14MP0003183_abnormal_peptide_metabolism3.00842124
15MP0005646_abnormal_pituitary_gland2.79907097
16MP0002837_dystrophic_cardiac_calcinosis2.75318511
17MP0005220_abnormal_exocrine_pancreas2.54436329
18MP0009046_muscle_twitch2.51132694
19MP0008877_abnormal_DNA_methylation2.36708243
20* MP0002078_abnormal_glucose_homeostasis2.34984857
21MP0006072_abnormal_retinal_apoptosis2.07807983
22MP0003122_maternal_imprinting2.06679074
23MP0010234_abnormal_vibrissa_follicle2.06454548
24MP0003880_abnormal_central_pattern2.04211020
25MP0004264_abnormal_extraembryonic_tissu1.93870748
26MP0002064_seizures1.83828741
27MP0005645_abnormal_hypothalamus_physiol1.82907017
28MP0002638_abnormal_pupillary_reflex1.80274790
29MP0001986_abnormal_taste_sensitivity1.79326483
30MP0002234_abnormal_pharynx_morphology1.78166540
31MP0000003_abnormal_adipose_tissue1.78020386
32MP0004270_analgesia1.76816984
33MP0009745_abnormal_behavioral_response1.76721505
34MP0000462_abnormal_digestive_system1.75726304
35MP0004510_myositis1.69478471
36MP0002896_abnormal_bone_mineralization1.55886141
37MP0002928_abnormal_bile_duct1.55062074
38MP0001984_abnormal_olfaction1.52160313
39MP0003300_gastrointestinal_ulcer1.51993682
40MP0001765_abnormal_ion_homeostasis1.50744454
41* MP0003953_abnormal_hormone_level1.43534371
42MP0003172_abnormal_lysosome_physiology1.35497935
43MP0008961_abnormal_basal_metabolism1.31599041
44MP0000613_abnormal_salivary_gland1.28388938
45MP0002102_abnormal_ear_morphology1.27364949
46MP0002876_abnormal_thyroid_physiology1.27011278
47MP0000631_abnormal_neuroendocrine_gland1.26994305
48MP0005535_abnormal_body_temperature1.26779885
49MP0003868_abnormal_feces_composition1.20703567
50MP0001440_abnormal_grooming_behavior1.20297145
51MP0002090_abnormal_vision1.18937710
52MP0005386_behavior/neurological_phenoty1.13757889
53MP0004924_abnormal_behavior1.13757889
54MP0003787_abnormal_imprinting1.12519508
55MP0005310_abnormal_salivary_gland1.11463784
56MP0005257_abnormal_intraocular_pressure1.10033721
57MP0009643_abnormal_urine_homeostasis1.09722069
58MP0002184_abnormal_innervation1.08040160
59MP0001188_hyperpigmentation1.06255877
60MP0005058_abnormal_lysosome_morphology1.05803141
61MP0003890_abnormal_embryonic-extraembry1.04953049
62MP0005551_abnormal_eye_electrophysiolog1.04610672
63MP0002067_abnormal_sensory_capabilities1.04551124
64MP0001270_distended_abdomen1.03697266
65MP0003119_abnormal_digestive_system1.03160108
66MP0001486_abnormal_startle_reflex1.02776987
67MP0003879_abnormal_hair_cell1.02049303
68MP0004885_abnormal_endolymph1.01006043
69MP0000778_abnormal_nervous_system0.99569267
70MP0001502_abnormal_circadian_rhythm0.98815345
71MP0002163_abnormal_gland_morphology0.97039493
72MP0002733_abnormal_thermal_nociception0.95425033
73MP0002734_abnormal_mechanical_nocicepti0.95106050
74MP0000639_abnormal_adrenal_gland0.93008571
75MP0003252_abnormal_bile_duct0.92387442
76MP0006054_spinal_hemorrhage0.89281954
77MP0001905_abnormal_dopamine_level0.88498115
78MP0003959_abnormal_lean_body0.88231155
79MP0002735_abnormal_chemical_nociception0.87979708
80MP0001299_abnormal_eye_distance/0.87757973
81MP0005365_abnormal_bile_salt0.87169467
82MP0002882_abnormal_neuron_morphology0.86896884
83MP0001756_abnormal_urination0.84984971
84MP0004145_abnormal_muscle_electrophysio0.83148058
85MP0005187_abnormal_penis_morphology0.82974856
86MP0000569_abnormal_digit_pigmentation0.82267792
87MP0005636_abnormal_mineral_homeostasis0.81696464
88MP0005423_abnormal_somatic_nervous0.81124020
89MP0000230_abnormal_systemic_arterial0.80905783
90MP0000681_abnormal_thyroid_gland0.80458431
91MP0003635_abnormal_synaptic_transmissio0.78640274
92MP0003045_fibrosis0.78306163
93MP0004142_abnormal_muscle_tone0.77185689
94MP0002066_abnormal_motor_capabilities/c0.76317416
95MP0003631_nervous_system_phenotype0.76234764
96MP0005253_abnormal_eye_physiology0.75974976
97MP0002138_abnormal_hepatobiliary_system0.75259541
98MP0001968_abnormal_touch/_nociception0.74593946
99MP0010329_abnormal_lipoprotein_level0.73088563
100MP0001970_abnormal_pain_threshold0.72935003
101MP0009672_abnormal_birth_weight0.72792329
102MP0008872_abnormal_physiological_respon0.71553357
103MP0000538_abnormal_urinary_bladder0.69180000
104MP0005375_adipose_tissue_phenotype0.68261759
105MP0001529_abnormal_vocalization0.66844254
106MP0000955_abnormal_spinal_cord0.66494629
107MP0008004_abnormal_stomach_pH0.66340825
108MP0002295_abnormal_pulmonary_circulatio0.65038833
109MP0002168_other_aberrant_phenotype0.64862153
110MP0006276_abnormal_autonomic_nervous0.64760560
111MP0003690_abnormal_glial_cell0.64650987
112MP0003011_delayed_dark_adaptation0.64558798
113MP0005332_abnormal_amino_acid0.64020908
114MP0002572_abnormal_emotion/affect_behav0.63797217
115MP0009703_decreased_birth_body0.62996221
116MP0001666_abnormal_nutrient_absorption0.62494117
117MP0002229_neurodegeneration0.59889806
118MP0002272_abnormal_nervous_system0.59771302
119MP0004085_abnormal_heartbeat0.58547348
120MP0001501_abnormal_sleep_pattern0.57633990
121* MP0005448_abnormal_energy_balance0.57471499
122MP0001664_abnormal_digestion0.55361921
123MP0005076_abnormal_cell_differentiation0.55231733
124* MP0002069_abnormal_eating/drinking_beha0.54860825
125MP0002118_abnormal_lipid_homeostasis0.54543610
126MP0001661_extended_life_span0.53187792
127MP0002139_abnormal_hepatobiliary_system0.53170436
128MP0003123_paternal_imprinting0.53058678
129MP0003633_abnormal_nervous_system0.53051379
130MP0002557_abnormal_social/conspecific_i0.51394752
131MP0002063_abnormal_learning/memory/cond0.51354053
132MP0002751_abnormal_autonomic_nervous0.50300469
133MP0004811_abnormal_neuron_physiology0.49997282
134MP0002177_abnormal_outer_ear0.48874805
135* MP0009642_abnormal_blood_homeostasis0.48431194
136MP0003795_abnormal_bone_structure0.46735227
137MP0003121_genomic_imprinting0.45875906
138* MP0005452_abnormal_adipose_tissue0.45836102
139MP0004859_abnormal_synaptic_plasticity0.45091565

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)8.51942013
2Hypoglycemic seizures (HP:0002173)7.64158219
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)7.08805514
4Symptomatic seizures (HP:0011145)6.96330091
5Hypoglycemic coma (HP:0001325)6.51546930
6Insulin-resistant diabetes mellitus (HP:0000831)5.33488448
7Hyperglycemia (HP:0003074)5.13309539
8Abnormality of endocrine pancreas physiology (HP:0012093)4.80901173
9Abnormality of the pancreatic islet cells (HP:0006476)4.80901173
10Pancreatic islet-cell hyperplasia (HP:0004510)4.67560470
11Abnormality of calcium-phosphate metabolism (HP:0100530)4.52912639
12Ketoacidosis (HP:0001993)4.48651505
13Large for gestational age (HP:0001520)4.32598650
14Abnormal pancreas size (HP:0012094)4.12002978
15Decreased circulating renin level (HP:0003351)4.03477459
16Late onset (HP:0003584)3.98710829
17Generalized aminoaciduria (HP:0002909)3.74365651
18Mucopolysacchariduria (HP:0008155)3.62639486
19Urinary glycosaminoglycan excretion (HP:0003541)3.62639486
20Hypokalemia (HP:0002900)3.47082911
21Agitation (HP:0000713)3.45762391
22Osteomalacia (HP:0002749)3.45069009
23Abnormality of polysaccharide metabolism (HP:0011012)3.33493596
24Abnormality of glycosaminoglycan metabolism (HP:0004371)3.33493596
25Abnormality of mucopolysaccharide metabolism (HP:0011020)3.33493596
26Hypomagnesemia (HP:0002917)3.21238555
27Dysostosis multiplex (HP:0000943)3.17873033
28Enlarged penis (HP:0000040)3.13841282
29Insulin resistance (HP:0000855)3.05730202
30Febrile seizures (HP:0002373)3.05185520
31Hyperparathyroidism (HP:0000843)2.99379986
32Epileptic encephalopathy (HP:0200134)2.99087651
33Conjugated hyperbilirubinemia (HP:0002908)2.95861144
34Abnormality of the intrinsic pathway (HP:0010989)2.90144993
35Prominent metopic ridge (HP:0005487)2.86590163
36EEG with generalized epileptiform discharges (HP:0011198)2.78602866
37Hypothermia (HP:0002045)2.76200694
38Hypsarrhythmia (HP:0002521)2.75105504
39Pheochromocytoma (HP:0002666)2.73782866
40Epileptiform EEG discharges (HP:0011182)2.71634433
41Abnormality of renin-angiotensin system (HP:0000847)2.71465482
42Visual hallucinations (HP:0002367)2.68990847
43Type I diabetes mellitus (HP:0100651)2.65219632
44Abnormality of potassium homeostasis (HP:0011042)2.63391972
45Retinal atrophy (HP:0001105)2.58908570
46Abnormality of magnesium homeostasis (HP:0004921)2.55916276
47Thoracolumbar scoliosis (HP:0002944)2.52390737
48Papilledema (HP:0001085)2.52143030
49Hyperthyroidism (HP:0000836)2.52093572
50Ketosis (HP:0001946)2.49351460
51Hemiparesis (HP:0001269)2.46309603
52Menstrual irregularities (HP:0000858)2.45857137
53Abnormality of the metopic suture (HP:0005556)2.44451276
54Aplasia/Hypoplasia of the fovea (HP:0008060)2.44204742
55Hypoplasia of the fovea (HP:0007750)2.44204742
56Focal seizures (HP:0007359)2.44059896
57Hypercortisolism (HP:0001578)2.42718290
58Dysautonomia (HP:0002459)2.41031727
59Abnormal sex determination (HP:0012244)2.36715119
60Sex reversal (HP:0012245)2.36715119
61Unilateral renal agenesis (HP:0000122)2.32347986
62Neuroendocrine neoplasm (HP:0100634)2.32168723
63Hyperactive renin-angiotensin system (HP:0000841)2.31896211
64Limb hypertonia (HP:0002509)2.29746326
65Abnormal drinking behavior (HP:0030082)2.27078287
66Polydipsia (HP:0001959)2.27078287
67Myokymia (HP:0002411)2.26316852
68Tetany (HP:0001281)2.25176386
69Chronic bronchitis (HP:0004469)2.24154536
70Downturned corners of mouth (HP:0002714)2.23005040
71Abdominal distention (HP:0003270)2.22877329
72Abnormality of the fovea (HP:0000493)2.20617861
73Abnormality of aromatic amino acid family metabolism (HP:0004338)2.19196357
74Exocrine pancreatic insufficiency (HP:0001738)2.17878571
75Dialeptic seizures (HP:0011146)2.16934575
76Gout (HP:0001997)2.14780803
77Progressive neurologic deterioration (HP:0002344)2.14577736
78Restlessness (HP:0000711)2.13340078
79Hyperkalemia (HP:0002153)2.12150237
80Anxiety (HP:0000739)2.11646432
81Diminished movement (HP:0002374)2.11484354
82Generalized tonic-clonic seizures (HP:0002069)2.11445416
83Akinesia (HP:0002304)2.10346288
84Hyperphosphatemia (HP:0002905)2.09278071
85Double outlet right ventricle (HP:0001719)2.08477510
86Congenital malformation of the right heart (HP:0011723)2.08477510
87Hypophosphatemia (HP:0002148)2.07516408
88Abnormal glycosylation (HP:0012345)2.06411086
89Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.06411086
90Abnormal protein N-linked glycosylation (HP:0012347)2.06411086
91Abnormal protein glycosylation (HP:0012346)2.06411086
92Absence seizures (HP:0002121)2.05845527
93Cortical visual impairment (HP:0100704)2.04311063
94Poor suck (HP:0002033)2.03508317
95Congenital glaucoma (HP:0001087)2.01031523
96Hypokinesia (HP:0002375)1.99887019
97Resting tremor (HP:0002322)1.98664189
98Increased circulating renin level (HP:0000848)1.95759195
99Intestinal atresia (HP:0011100)1.94386995
100Hypotension (HP:0002615)1.92721826
101Hyperphosphaturia (HP:0003109)1.92191295
102Intention tremor (HP:0002080)1.91672651
103Oligomenorrhea (HP:0000876)1.90339794
104Protuberant abdomen (HP:0001538)1.89043576
105Adrenal overactivity (HP:0002717)1.88928099
106Hyperventilation (HP:0002883)1.88164476
107Amblyopia (HP:0000646)1.86818954
108Irregular vertebral endplates (HP:0003301)1.86166106
109Metaphyseal dysplasia (HP:0100255)1.85350012
110Failure to thrive in infancy (HP:0001531)1.85277453
111Fetal akinesia sequence (HP:0001989)1.85248386
112Polyphagia (HP:0002591)1.81128250
113Atonic seizures (HP:0010819)1.79104741
114Papillary thyroid carcinoma (HP:0002895)1.78422976
115Tachypnea (HP:0002789)1.76873588
116Macroorchidism (HP:0000053)1.76191816
117Abnormal eating behavior (HP:0100738)1.75298213
118Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.74715021
119Broad-based gait (HP:0002136)1.74279332
120Drooling (HP:0002307)1.72950591
121Hypoplastic labia majora (HP:0000059)1.72830262
122Muscular hypotonia of the trunk (HP:0008936)1.71830871
123Abnormality of purine metabolism (HP:0004352)1.71586925
124Limb dystonia (HP:0002451)1.71439463
125Hypokalemic alkalosis (HP:0001949)1.70935927
126Elevated alkaline phosphatase (HP:0003155)1.70236345
127Gait imbalance (HP:0002141)1.69187164
128Ventricular fibrillation (HP:0001663)1.68741973
129Postural tremor (HP:0002174)1.68731246
130Abnormal biliary tract morphology (HP:0012440)1.68716673
131Growth hormone excess (HP:0000845)1.67726643
132Disproportionate short-trunk short stature (HP:0003521)1.66810186
133Focal motor seizures (HP:0011153)1.66461570
134Generalized hyperpigmentation (HP:0007440)1.66057572
135Acute hepatic failure (HP:0006554)1.65516254
136Medial flaring of the eyebrow (HP:0010747)1.65228861
137Testicular neoplasm (HP:0010788)1.63894436
138Gaze-evoked nystagmus (HP:0000640)1.63701680
139Basal ganglia calcification (HP:0002135)1.63433598
140Type I transferrin isoform profile (HP:0003642)1.63279572
141Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.62841080
142Skin nodule (HP:0200036)1.62166549
143Hamartoma of the eye (HP:0010568)1.62139822
144Severe short stature (HP:0003510)1.61631512
145Neoplasm of the adrenal cortex (HP:0100641)1.61437851
146Hepatoblastoma (HP:0002884)1.61090788
147Abnormality of the common coagulation pathway (HP:0010990)1.60764221
148Ankle clonus (HP:0011448)1.60191098
149Status epilepticus (HP:0002133)1.58630627
150Depression (HP:0000716)1.55838812
151Excessive salivation (HP:0003781)1.55732383
152Aqueductal stenosis (HP:0002410)1.53352591
153Tongue fasciculations (HP:0001308)1.51779282
154Truncal ataxia (HP:0002078)1.49158633
155Steatorrhea (HP:0002570)1.47927545
156Congenital primary aphakia (HP:0007707)1.44720816
157Small for gestational age (HP:0001518)1.42474164
158Thyroid carcinoma (HP:0002890)1.42105267

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR7.53551840
2PASK6.42439074
3MAPK153.96952954
4TAOK33.79782761
5HIPK23.36413888
6PRKD33.19844094
7MAP3K23.01418166
8FGFR22.55027207
9NTRK32.36390241
10MARK12.34060637
11FRK2.29815495
12MAP4K22.20500500
13SCYL22.16845542
14NTRK12.14891789
15FLT32.13249295
16ERN11.94633145
17UHMK11.90929627
18CAMKK21.84836365
19MAP3K91.75812886
20MAP3K11.74960923
21AKT31.70621416
22TNIK1.61180629
23WNK41.56335160
24PHKG21.56253902
25PHKG11.56253902
26PINK11.54368763
27EPHA31.51541023
28PDGFRA1.45461511
29IRAK31.43951616
30CDC42BPA1.39320354
31ACVR1B1.35669934
32IRAK11.35640918
33BRSK21.34781212
34LMTK21.32910989
35PRKCH1.25730757
36CSNK1G21.22753658
37PNCK1.21759896
38CSNK1G11.19927431
39PTK21.19097467
40CSNK1G31.13145896
41TRPM71.13119766
42ERBB31.05653151
43PAK31.00210964
44STK38L0.97984390
45EIF2AK30.97219185
46DYRK1B0.96410842
47BMPR1B0.95497498
48PTK60.91968115
49PLK20.91853325
50BRSK10.90114975
51TRIM280.89954308
52MET0.87514855
53WNK30.86250851
54STK110.86025498
55IRAK20.84324884
56PRKCE0.82879387
57PRKD20.82236749
58CAMK1G0.82059151
59ADRBK20.81570572
60STK390.79053039
61RET0.78974196
62BRAF0.77885949
63EPHA40.77806641
64EPHB10.74837897
65CCNB10.74696623
66TRIB30.73975953
67CAMK10.73891651
68GRK10.72965512
69NTRK20.72731952
70OXSR10.70312746
71LIMK10.69883502
72MAPK130.69283008
73DAPK10.68982254
74CAMKK10.68853990
75MAP2K60.67292719
76FER0.65877820
77SIK10.65182279
78MINK10.62706376
79JAK20.62683499
80PRKAA20.62465814
81CAMK2D0.62196463
82MAP3K40.61176846
83MAP3K120.60837508
84MAP2K40.59737602
85ITK0.58799461
86MAP2K20.57791248
87DYRK20.57700872
88PTK2B0.56967578
89PRKCI0.51853080
90WNK10.51753360
91PAK60.50326645
92CDK50.49214333
93MARK20.49032355
94RPS6KA20.48469035
95PRKAA10.48376362
96CSNK1A1L0.48116856
97SGK2230.47411714
98SGK4940.47411714
99FGFR40.47349537
100STK380.47117357
101BCKDK0.46907184
102CAMK2B0.45707116
103SGK20.45629566
104GRK50.44660867
105CASK0.44563133
106BRD40.44511372
107CDK30.44385349
108YES10.43002457
109PRKACG0.42253870
110STK30.40927740
111JAK10.40319893
112CSNK1A10.39526373
113MAP3K30.38967510
114BCR0.38904843
115KSR20.36253529
116PRKACA0.35829110
117FGFR30.35661965
118PRKCG0.35312030
119CSNK1E0.33916139
120PRKD10.33646703
121GSK3A0.32861407
122PIK3CG0.32830063
123ALK0.32087127
124ADRBK10.31107178
125MAP2K70.30352219
126PRKCZ0.30278043
127PRKDC0.30236135
128NLK0.29691680
129IGF1R0.28881459
130RPS6KB10.28093398
131RIPK10.28009559
132SGK30.27278321
133NEK60.26202919
134MAPK140.24788793
135PRKCA0.23446873
136DAPK20.23066164
137RPS6KA30.22338942
138TESK10.22232444
139PRKCB0.22205619
140MAP2K10.21893132
141CAMK2A0.20942220
142PDGFRB0.20641238
143SGK10.18343320
144PRKG10.18149142
145TSSK60.17690141
146BMPR20.17685459
147DYRK1A0.17579064
148LATS10.17017578

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049509.00476443
2Protein export_Homo sapiens_hsa030605.14713260
3Insulin secretion_Homo sapiens_hsa049113.39834972
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.32724320
5Sulfur metabolism_Homo sapiens_hsa009203.29085590
6Type II diabetes mellitus_Homo sapiens_hsa049302.57653058
7Vibrio cholerae infection_Homo sapiens_hsa051102.31519986
8Type I diabetes mellitus_Homo sapiens_hsa049402.25873302
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.09239616
10Carbohydrate digestion and absorption_Homo sapiens_hsa049731.96850565
11Nicotine addiction_Homo sapiens_hsa050331.90875206
12Cocaine addiction_Homo sapiens_hsa050301.87150885
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.85304241
14N-Glycan biosynthesis_Homo sapiens_hsa005101.73158541
15Amphetamine addiction_Homo sapiens_hsa050311.56042658
16Selenocompound metabolism_Homo sapiens_hsa004501.53344672
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45728957
18Taste transduction_Homo sapiens_hsa047421.40837282
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.36554116
20Synaptic vesicle cycle_Homo sapiens_hsa047211.32161835
21Lysosome_Homo sapiens_hsa041421.27100396
22Vitamin B6 metabolism_Homo sapiens_hsa007501.19089102
23Pancreatic secretion_Homo sapiens_hsa049721.17488778
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.16079615
25Fatty acid elongation_Homo sapiens_hsa000621.13074555
26Dopaminergic synapse_Homo sapiens_hsa047281.12009081
27Circadian rhythm_Homo sapiens_hsa047101.11911394
28Thyroid hormone synthesis_Homo sapiens_hsa049181.11552932
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.10927113
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.10745452
31Collecting duct acid secretion_Homo sapiens_hsa049661.09561629
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09417616
33Long-term potentiation_Homo sapiens_hsa047201.07499064
34Glucagon signaling pathway_Homo sapiens_hsa049221.07287345
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04010840
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.01818000
37Circadian entrainment_Homo sapiens_hsa047130.98483748
38GABAergic synapse_Homo sapiens_hsa047270.97933224
39Serotonergic synapse_Homo sapiens_hsa047260.95511096
40Insulin resistance_Homo sapiens_hsa049310.95498568
41Regulation of autophagy_Homo sapiens_hsa041400.95143484
42Cholinergic synapse_Homo sapiens_hsa047250.94380256
43Prolactin signaling pathway_Homo sapiens_hsa049170.87937684
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87852472
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83581203
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80624264
47Phototransduction_Homo sapiens_hsa047440.80408070
48Prion diseases_Homo sapiens_hsa050200.79982123
49Estrogen signaling pathway_Homo sapiens_hsa049150.79625886
50Tryptophan metabolism_Homo sapiens_hsa003800.78504013
51ABC transporters_Homo sapiens_hsa020100.76811035
52Other glycan degradation_Homo sapiens_hsa005110.72592768
53Morphine addiction_Homo sapiens_hsa050320.70909804
54Galactose metabolism_Homo sapiens_hsa000520.70809225
55Butanoate metabolism_Homo sapiens_hsa006500.69850180
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69252599
57Fatty acid metabolism_Homo sapiens_hsa012120.66091752
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66001828
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65666742
60Folate biosynthesis_Homo sapiens_hsa007900.61417124
61Ether lipid metabolism_Homo sapiens_hsa005650.61068389
62Oxidative phosphorylation_Homo sapiens_hsa001900.60971244
63Renin secretion_Homo sapiens_hsa049240.60789247
64Alcoholism_Homo sapiens_hsa050340.60193925
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58794625
66Cardiac muscle contraction_Homo sapiens_hsa042600.55529047
67Oxytocin signaling pathway_Homo sapiens_hsa049210.54217077
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52416390
69Insulin signaling pathway_Homo sapiens_hsa049100.51555868
70beta-Alanine metabolism_Homo sapiens_hsa004100.51547311
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51507536
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.51271479
73Phenylalanine metabolism_Homo sapiens_hsa003600.49069181
74Sphingolipid metabolism_Homo sapiens_hsa006000.48740726
75Glutamatergic synapse_Homo sapiens_hsa047240.48530042
76Mineral absorption_Homo sapiens_hsa049780.47294249
77Bile secretion_Homo sapiens_hsa049760.46241597
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45164250
79Starch and sucrose metabolism_Homo sapiens_hsa005000.43890738
80Calcium signaling pathway_Homo sapiens_hsa040200.43091231
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42726191
82cAMP signaling pathway_Homo sapiens_hsa040240.41168561
83mTOR signaling pathway_Homo sapiens_hsa041500.40701770
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38480909
85Axon guidance_Homo sapiens_hsa043600.35810397
86Inositol phosphate metabolism_Homo sapiens_hsa005620.35727063
87Gastric acid secretion_Homo sapiens_hsa049710.35246522
88Oocyte meiosis_Homo sapiens_hsa041140.34318317
89Long-term depression_Homo sapiens_hsa047300.33863380
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32611588
91Ras signaling pathway_Homo sapiens_hsa040140.32027193
92Antigen processing and presentation_Homo sapiens_hsa046120.32001748
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31376730
94Dorso-ventral axis formation_Homo sapiens_hsa043200.31151064
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30695601
96Gap junction_Homo sapiens_hsa045400.30624800
97Peroxisome_Homo sapiens_hsa041460.30574886
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27323444
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27119932
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26807304
101AMPK signaling pathway_Homo sapiens_hsa041520.26805068
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25473036
103Olfactory transduction_Homo sapiens_hsa047400.25440756
104Thyroid cancer_Homo sapiens_hsa052160.25434285
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25274884
106Phagosome_Homo sapiens_hsa041450.24811701
107Melanogenesis_Homo sapiens_hsa049160.24700457
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23680513
109Prostate cancer_Homo sapiens_hsa052150.23087442
110Salivary secretion_Homo sapiens_hsa049700.22053912
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.21829440
112Histidine metabolism_Homo sapiens_hsa003400.20805367
113GnRH signaling pathway_Homo sapiens_hsa049120.20357397
114Tyrosine metabolism_Homo sapiens_hsa003500.20036146
115Fat digestion and absorption_Homo sapiens_hsa049750.19856241
116Linoleic acid metabolism_Homo sapiens_hsa005910.19585668
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18498964
118Fructose and mannose metabolism_Homo sapiens_hsa000510.18397674
119Ovarian steroidogenesis_Homo sapiens_hsa049130.17966209
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15530660
121Protein digestion and absorption_Homo sapiens_hsa049740.15320791
122Bladder cancer_Homo sapiens_hsa052190.14631046
123Alzheimers disease_Homo sapiens_hsa050100.14570979
124Lysine degradation_Homo sapiens_hsa003100.13777340

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