PCSK1N

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene functions as an inhibitor of prohormone convertase 1, which regulates the proteolytic cleavage of neuroendocrine peptide precursors. The proprotein is further processed into multiple short peptides. A polymorphism within this gene may be associated with obesity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.73053839
2Golgi transport vesicle coating (GO:0048200)5.58543079
3COPI coating of Golgi vesicle (GO:0048205)5.58543079
4synaptic vesicle maturation (GO:0016188)5.31153224
5postsynaptic membrane organization (GO:0001941)4.91413632
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.75774860
7regulation of synaptic vesicle exocytosis (GO:2000300)4.61169416
8positive regulation of synapse maturation (GO:0090129)4.34861682
9positive regulation of synaptic transmission, GABAergic (GO:0032230)4.29699297
10ionotropic glutamate receptor signaling pathway (GO:0035235)4.28645615
11sodium ion export (GO:0071436)4.21134346
12synaptic vesicle exocytosis (GO:0016079)4.16290068
13regulation of synaptic vesicle transport (GO:1902803)4.11617776
14locomotory exploration behavior (GO:0035641)4.08516826
15insulin secretion (GO:0030073)4.01238119
16neuronal ion channel clustering (GO:0045161)3.99211182
17positive regulation of insulin secretion (GO:0032024)3.94207019
18auditory behavior (GO:0031223)3.93499240
19negative regulation of synaptic transmission, GABAergic (GO:0032229)3.92444461
20protein maturation by protein folding (GO:0022417)3.91182502
21establishment of mitochondrion localization (GO:0051654)3.86775422
22central nervous system myelination (GO:0022010)3.86009971
23axon ensheathment in central nervous system (GO:0032291)3.86009971
24retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.84937693
25neuronal action potential propagation (GO:0019227)3.84169622
26neurotransmitter-gated ion channel clustering (GO:0072578)3.83237999
27positive regulation of dendritic spine development (GO:0060999)3.81993698
28glutamate secretion (GO:0014047)3.81009079
29pyrimidine nucleobase catabolic process (GO:0006208)3.78954703
30neuromuscular process controlling posture (GO:0050884)3.76502527
31maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.74105619
32neurotransmitter secretion (GO:0007269)3.66566242
33endocrine pancreas development (GO:0031018)3.64592192
34detection of calcium ion (GO:0005513)3.64162106
35activation of protein kinase A activity (GO:0034199)3.63169720
36cerebellar granule cell differentiation (GO:0021707)3.62879816
37glycine transport (GO:0015816)3.62419574
38* peptide hormone processing (GO:0016486)3.60179061
39protein retention in ER lumen (GO:0006621)3.60172044
40cell migration in hindbrain (GO:0021535)3.59968080
41synaptic vesicle endocytosis (GO:0048488)3.59260781
42positive regulation of vesicle fusion (GO:0031340)3.56644354
43potassium ion homeostasis (GO:0055075)3.54939793
44presynaptic membrane organization (GO:0097090)3.52280325
45regulation of vesicle fusion (GO:0031338)3.51730380
46regulation of voltage-gated calcium channel activity (GO:1901385)3.51376067
47cellular response to glucagon stimulus (GO:0071377)3.51170129
48neuron-neuron synaptic transmission (GO:0007270)3.49697752
49presynaptic membrane assembly (GO:0097105)3.48375540
50positive regulation of neurotransmitter transport (GO:0051590)3.46109752
51regulation of insulin secretion (GO:0050796)3.45994864
52regulation of type B pancreatic cell apoptotic process (GO:2000674)3.45584520
53positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.45346812
54L-amino acid import (GO:0043092)3.45002319
55regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.44957705
56regulation of calcium ion-dependent exocytosis (GO:0017158)3.44919694
57regulation of synapse maturation (GO:0090128)3.44489813
58glutamate receptor signaling pathway (GO:0007215)3.43565475
59regulation of excitatory postsynaptic membrane potential (GO:0060079)3.43464840
60positive regulation of peptide hormone secretion (GO:0090277)3.43123752
61regulation of neurotransmitter transport (GO:0051588)3.42396701
62regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.41841004
63positive regulation of peptide secretion (GO:0002793)3.41565740
64positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.40184957
65cerebellar Purkinje cell layer development (GO:0021680)3.38572045
66potassium ion import (GO:0010107)3.37483242
67regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.35070893
68response to auditory stimulus (GO:0010996)3.34380103
69nucleobase catabolic process (GO:0046113)3.32606117
70chemosensory behavior (GO:0007635)3.31157697
71regulation of postsynaptic membrane potential (GO:0060078)3.29961260
72regulation of neuronal synaptic plasticity (GO:0048168)3.29495670
73transmission of nerve impulse (GO:0019226)3.29015273
74regulation of synaptic plasticity (GO:0048167)3.28275391
75synaptic vesicle docking involved in exocytosis (GO:0016081)3.27870465
76regulation of dendritic spine morphogenesis (GO:0061001)3.25081036
77amino acid import (GO:0043090)3.24095214
78peptide hormone secretion (GO:0030072)3.21593971
79regulation of peptide hormone secretion (GO:0090276)3.19475469
80regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.19349367
81nitric oxide mediated signal transduction (GO:0007263)3.17992856
82regulation of peptide secretion (GO:0002791)3.16831959
83cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.16539468
84positive regulation of amino acid transport (GO:0051957)3.16223073
85vocalization behavior (GO:0071625)3.16189544
86neuromuscular process controlling balance (GO:0050885)3.15546469
87regulation of dendritic spine development (GO:0060998)3.14489440
88regulation of glutamate receptor signaling pathway (GO:1900449)3.14105201
89axonal fasciculation (GO:0007413)3.13164994
90neuron recognition (GO:0008038)3.12207453
91positive regulation of dendritic spine morphogenesis (GO:0061003)3.11994407
92positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.11333241
93peptide secretion (GO:0002790)3.10449950
94mitochondrion transport along microtubule (GO:0047497)3.10120615
95establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.10120615
96exploration behavior (GO:0035640)3.09899038
97positive regulation of neurotransmitter secretion (GO:0001956)3.08444964
98adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.08106456
99signal release (GO:0023061)3.05660482
100innervation (GO:0060384)3.05283183
101positive regulation of exocytosis (GO:0045921)3.04593999
102negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.03703289
103neuromuscular synaptic transmission (GO:0007274)3.01621630
104establishment of synaptic vesicle localization (GO:0097480)2.99296193
105synaptic vesicle transport (GO:0048489)2.99296193
106regulation of amyloid precursor protein catabolic process (GO:1902991)2.99113079
107acidic amino acid transport (GO:0015800)2.98427689
108positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.97787214
109response to pheromone (GO:0019236)2.97188042
110regulation of long-term neuronal synaptic plasticity (GO:0048169)2.96421630
111glandular epithelial cell differentiation (GO:0002067)2.96155082
112cerebellar Purkinje cell differentiation (GO:0021702)2.96122898
113synapse assembly (GO:0007416)2.95869398
114cell communication by electrical coupling (GO:0010644)2.95788766
115L-alpha-amino acid transmembrane transport (GO:1902475)2.95630111
116regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.95333787
117regulation of synapse structural plasticity (GO:0051823)2.93927624
118toxin metabolic process (GO:0009404)2.93616027
119membrane depolarization (GO:0051899)2.93417018
120regulation of norepinephrine secretion (GO:0014061)2.92944234
121vesicle coating (GO:0006901)2.92756858
122regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.92621989
123COPII vesicle coating (GO:0048208)2.91804466
124neuron cell-cell adhesion (GO:0007158)2.91131688
125dendritic spine morphogenesis (GO:0060997)2.91112093
126membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.90990924
127synaptic transmission (GO:0007268)2.90516840
128protein localization to synapse (GO:0035418)2.90041523
129cellular sodium ion homeostasis (GO:0006883)2.89104944
130neurotransmitter transport (GO:0006836)2.87764601
131regulation of synaptic transmission (GO:0050804)2.87632147
132vesicle transport along microtubule (GO:0047496)2.87591805
133growth hormone secretion (GO:0030252)2.87580689
134membrane hyperpolarization (GO:0060081)2.86110155
135regulation of exocytosis (GO:0017157)2.85282090
136layer formation in cerebral cortex (GO:0021819)2.83992372
137regulation of glucocorticoid secretion (GO:2000849)2.81623762
138regulation of hormone secretion (GO:0046883)2.80962665
139negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.74405023
140suckling behavior (GO:0001967)2.70651608
141regulation of beta-amyloid formation (GO:1902003)2.69397398
142positive regulation of membrane potential (GO:0045838)2.69292783
143membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.68936740
144gamma-aminobutyric acid transport (GO:0015812)2.68301721
145positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.68172854
146calcium ion-dependent exocytosis (GO:0017156)2.66416169
147regulation of neurotransmitter secretion (GO:0046928)2.65927595
148dendritic spine organization (GO:0097061)2.65606873
149cellular potassium ion homeostasis (GO:0030007)2.65321022
150synaptic transmission, glutamatergic (GO:0035249)2.65172101
151positive regulation of hormone secretion (GO:0046887)2.64121273
152organelle transport along microtubule (GO:0072384)2.61476430
153regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.60758428
154regulation of neurotransmitter levels (GO:0001505)2.60569385
155proline transport (GO:0015824)2.59763160
156membrane repolarization during action potential (GO:0086011)2.58687081
157regulation of synaptic transmission, GABAergic (GO:0032228)2.58222449
158positive regulation of amine transport (GO:0051954)2.58084982
159mechanosensory behavior (GO:0007638)2.56790239

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.64415901
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.10200393
3REST_21632747_ChIP-Seq_MESCs_Mouse2.96616862
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.82721246
5CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.76901217
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.71041205
7REST_18959480_ChIP-ChIP_MESCs_Mouse2.70824485
8SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.68858016
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.65805790
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.55779169
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50670708
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.46657357
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42748989
14EZH2_27294783_Chip-Seq_ESCs_Mouse2.38567692
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.36455232
16SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35941196
17GBX2_23144817_ChIP-Seq_PC3_Human2.33017156
18IKZF1_21737484_ChIP-ChIP_HCT116_Human2.27690637
19DROSHA_22980978_ChIP-Seq_HELA_Human2.26080436
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.20288036
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.17570215
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.15575147
23RNF2_18974828_ChIP-Seq_MESCs_Mouse2.15575147
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15574419
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06256580
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.05395107
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04105557
28CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.01611038
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.94168877
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.87936368
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.79184490
32IGF1R_20145208_ChIP-Seq_DFB_Human1.71212400
33NR3C1_23031785_ChIP-Seq_PC12_Mouse1.70578800
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69917446
35DNAJC2_21179169_ChIP-ChIP_NT2_Human1.63898697
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.60294500
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59883136
38RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.59634161
39OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.56946395
40ZNF274_21170338_ChIP-Seq_K562_Hela1.51213329
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47553517
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39447453
43ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38182810
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33692755
45TP53_20018659_ChIP-ChIP_R1E_Mouse1.25174729
46DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24897389
47EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23049154
48KDM2B_26808549_Chip-Seq_K562_Human1.22677867
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19288309
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17949164
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16907635
52* RING1B_27294783_Chip-Seq_ESCs_Mouse1.15665593
53AR_19668381_ChIP-Seq_PC3_Human1.14090220
54SMAD4_21799915_ChIP-Seq_A2780_Human1.13703387
55ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13372930
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.12445597
57SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.11155030
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10552098
59TET1_21490601_ChIP-Seq_MESCs_Mouse1.10380324
60SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10114764
61CTCF_27219007_Chip-Seq_Bcells_Human1.10008550
62CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.05626384
63STAT3_23295773_ChIP-Seq_U87_Human1.04013052
64AR_21572438_ChIP-Seq_LNCaP_Human1.03777557
65VDR_22108803_ChIP-Seq_LS180_Human1.02800694
66SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02065362
67SMAD3_21741376_ChIP-Seq_ESCs_Human1.01227133
68LXR_22292898_ChIP-Seq_THP-1_Human0.97313911
69OCT4_19829295_ChIP-Seq_ESCs_Human0.96132841
70SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93095816
71CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92781533
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92736010
73PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92693585
74DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91809691
75RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91491599
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91353444
77YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91336343
78* REST_19997604_ChIP-ChIP_NEURONS_Mouse0.89809981
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89538361
80SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89044241
81P68_20966046_ChIP-Seq_HELA_Human0.88763252
82KLF4_19829295_ChIP-Seq_ESCs_Human0.88491114
83SMC4_20622854_ChIP-Seq_HELA_Human0.88383387
84PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87177289
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87107144
86SMAD4_21741376_ChIP-Seq_HESCs_Human0.86965977
87GATA1_26923725_Chip-Seq_HPCs_Mouse0.86906415
88SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85703824
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83743190
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83343000
91RING1B_27294783_Chip-Seq_NPCs_Mouse0.83100615
92NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.82064609
93ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82036110
94TRIM28_21343339_ChIP-Seq_HEK293_Human0.81962264
95RNF2_27304074_Chip-Seq_NSC_Mouse0.81034402
96TOP2B_26459242_ChIP-Seq_MCF-7_Human0.80889925
97TET1_21451524_ChIP-Seq_MESCs_Mouse0.80466645
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.80371864
99ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.78828745
100RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.78423043
101PIAS1_25552417_ChIP-Seq_VCAP_Human0.77705413
102CBX2_27304074_Chip-Seq_ESCs_Mouse0.77277547
103DPY_21335234_ChIP-Seq_ESCs_Mouse0.77183734
104TCF4_23295773_ChIP-Seq_U87_Human0.77174379
105AR_25329375_ChIP-Seq_VCAP_Human0.76645865
106LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76191654
107ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.76058813
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75587644
109TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.75575367
110ETV2_25802403_ChIP-Seq_MESCs_Mouse0.75540673
111ZNF217_24962896_ChIP-Seq_MCF-7_Human0.75121868
112ZFP281_27345836_Chip-Seq_ESCs_Mouse0.75107682
113TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.75070687
114MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.75058517
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.74957372
116MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.74507348
117SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.74079797
118P53_22127205_ChIP-Seq_FIBROBLAST_Human0.73886688
119CREB1_26743006_Chip-Seq_LNCaP_Human0.73624880
120SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.73285386
121SMAD4_21741376_ChIP-Seq_ESCs_Human0.73140988
122P300_19829295_ChIP-Seq_ESCs_Human0.73062459
123SOX3_22085726_ChIP-Seq_NPCs_Mouse0.70175939
124KDM2B_26808549_Chip-Seq_SUP-B15_Human0.69164948
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.68622925
126SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.68036253

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.01748771
2MP0000013_abnormal_adipose_tissue4.00925003
3MP0002909_abnormal_adrenal_gland3.74566544
4MP0004270_analgesia3.55629473
5MP0003283_abnormal_digestive_organ3.43587134
6MP0005645_abnormal_hypothalamus_physiol3.17420096
7MP0005379_endocrine/exocrine_gland_phen2.98960481
8MP0003635_abnormal_synaptic_transmissio2.84888161
9MP0009780_abnormal_chondrocyte_physiolo2.79985785
10MP0003183_abnormal_peptide_metabolism2.64810163
11MP0003122_maternal_imprinting2.64397502
12MP0003880_abnormal_central_pattern2.51490315
13MP0004043_abnormal_pH_regulation2.40573291
14MP0010386_abnormal_urinary_bladder2.36047537
15MP0002734_abnormal_mechanical_nocicepti2.27143119
16MP0002837_dystrophic_cardiac_calcinosis2.21528523
17MP0009745_abnormal_behavioral_response2.20821920
18MP0002063_abnormal_learning/memory/cond2.19323563
19MP0001944_abnormal_pancreas_morphology2.18863906
20MP0002693_abnormal_pancreas_physiology2.17600848
21MP0002733_abnormal_thermal_nociception2.15175094
22MP0003195_calcinosis2.14959129
23MP0002064_seizures2.11562379
24MP0000003_abnormal_adipose_tissue1.95782362
25MP0002272_abnormal_nervous_system1.95470855
26* MP0002572_abnormal_emotion/affect_behav1.94034556
27MP0001968_abnormal_touch/_nociception1.87253705
28MP0001970_abnormal_pain_threshold1.83339425
29MP0005646_abnormal_pituitary_gland1.80049504
30MP0009046_muscle_twitch1.78407225
31MP0005423_abnormal_somatic_nervous1.77447919
32MP0002822_catalepsy1.77424157
33MP0002638_abnormal_pupillary_reflex1.74461641
34MP0002163_abnormal_gland_morphology1.73721022
35MP0008961_abnormal_basal_metabolism1.73354052
36MP0001502_abnormal_circadian_rhythm1.71080907
37MP0006276_abnormal_autonomic_nervous1.69073804
38MP0002877_abnormal_melanocyte_morpholog1.68532047
39MP0002735_abnormal_chemical_nociception1.63541109
40MP0006072_abnormal_retinal_apoptosis1.59485819
41MP0001986_abnormal_taste_sensitivity1.54003264
42MP0003787_abnormal_imprinting1.51499787
43MP0002184_abnormal_innervation1.50751999
44MP0004858_abnormal_nervous_system1.48832412
45MP0000678_abnormal_parathyroid_gland1.47972151
46MP0001486_abnormal_startle_reflex1.47934539
47MP0002557_abnormal_social/conspecific_i1.47896049
48MP0000955_abnormal_spinal_cord1.45510864
49MP0002078_abnormal_glucose_homeostasis1.44682006
50MP0001188_hyperpigmentation1.44649556
51MP0001501_abnormal_sleep_pattern1.43691050
52MP0003879_abnormal_hair_cell1.42969280
53MP0003690_abnormal_glial_cell1.39360215
54MP0003329_amyloid_beta_deposits1.39177589
55MP0004811_abnormal_neuron_physiology1.30696490
56MP0002067_abnormal_sensory_capabilities1.26494223
57MP0001529_abnormal_vocalization1.24474260
58MP0000920_abnormal_myelination1.23274199
59MP0008569_lethality_at_weaning1.22990062
60MP0004885_abnormal_endolymph1.22753231
61MP0002736_abnormal_nociception_after1.19697636
62MP0001440_abnormal_grooming_behavior1.19137491
63MP0005220_abnormal_exocrine_pancreas1.17990424
64MP0003633_abnormal_nervous_system1.15458349
65MP0001765_abnormal_ion_homeostasis1.15453664
66MP0005386_behavior/neurological_phenoty1.13934153
67MP0004924_abnormal_behavior1.13934153
68MP0004742_abnormal_vestibular_system1.09245354
69MP0003172_abnormal_lysosome_physiology1.09154264
70MP0005535_abnormal_body_temperature1.08912295
71MP0000631_abnormal_neuroendocrine_gland1.07914304
72MP0003953_abnormal_hormone_level1.04848259
73MP0004145_abnormal_muscle_electrophysio1.04413418
74MP0002882_abnormal_neuron_morphology1.02863143
75MP0001963_abnormal_hearing_physiology1.02314032
76MP0003123_paternal_imprinting1.01830335
77MP0001984_abnormal_olfaction1.01462098
78MP0003959_abnormal_lean_body1.01316407
79* MP0002066_abnormal_motor_capabilities/c1.00847018
80MP0002234_abnormal_pharynx_morphology1.00000198
81MP0002069_abnormal_eating/drinking_beha0.99910169
82MP0002751_abnormal_autonomic_nervous0.98198731
83MP0005551_abnormal_eye_electrophysiolog0.96752517
84MP0008877_abnormal_DNA_methylation0.95049341
85MP0000604_amyloidosis0.93724450
86MP0000639_abnormal_adrenal_gland0.92445046
87MP0003121_genomic_imprinting0.91672814
88MP0001177_atelectasis0.91326983
89MP0003632_abnormal_nervous_system0.89598215
90MP0004142_abnormal_muscle_tone0.89575025
91MP0002876_abnormal_thyroid_physiology0.87502872
92MP0002752_abnormal_somatic_nervous0.86075422
93MP0002229_neurodegeneration0.84427533
94MP0000462_abnormal_digestive_system0.83502677
95MP0000778_abnormal_nervous_system0.82356090
96MP0001756_abnormal_urination0.79668551
97MP0003634_abnormal_glial_cell0.79261042
98MP0001905_abnormal_dopamine_level0.79047195
99MP0002653_abnormal_ependyma_morphology0.78595418
100MP0001485_abnormal_pinna_reflex0.77609903
101MP0000026_abnormal_inner_ear0.77395790
102MP0005448_abnormal_energy_balance0.77189337
103MP0005167_abnormal_blood-brain_barrier0.75849114
104MP0002928_abnormal_bile_duct0.74790980
105MP0000230_abnormal_systemic_arterial0.73467344
106MP0001299_abnormal_eye_distance/0.73378701
107MP0003631_nervous_system_phenotype0.73113109
108MP0005253_abnormal_eye_physiology0.69049813
109MP0002249_abnormal_larynx_morphology0.68989025
110MP0005084_abnormal_gallbladder_morpholo0.68066295
111MP0005623_abnormal_meninges_morphology0.68031152
112MP0003938_abnormal_ear_development0.67989971
113MP0002152_abnormal_brain_morphology0.67869334
114MP0001664_abnormal_digestion0.67532350
115MP0003861_abnormal_nervous_system0.67497639
116MP0004085_abnormal_heartbeat0.67417600
117MP0000681_abnormal_thyroid_gland0.67023871
118MP0002896_abnormal_bone_mineralization0.66131342
119MP0005375_adipose_tissue_phenotype0.65537861
120MP0005394_taste/olfaction_phenotype0.64837786
121MP0005499_abnormal_olfactory_system0.64837786
122MP0001346_abnormal_lacrimal_gland0.64194808
123MP0003119_abnormal_digestive_system0.63703513
124MP0003137_abnormal_impulse_conducting0.62627215
125MP0008872_abnormal_physiological_respon0.62136941
126MP0004133_heterotaxia0.62132803
127MP0000566_synostosis0.60078929
128MP0001943_abnormal_respiration0.58898866
129MP0008874_decreased_physiological_sensi0.58455273
130MP0010769_abnormal_survival0.56392400
131MP0002082_postnatal_lethality0.54935482
132MP0010770_preweaning_lethality0.54935482
133MP0010768_mortality/aging0.53103177
134MP0004130_abnormal_muscle_cell0.51956672

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.69980471
2Hyperinsulinemic hypoglycemia (HP:0000825)5.66464820
3Hypoglycemic seizures (HP:0002173)5.50885265
4Symptomatic seizures (HP:0011145)4.85677134
5Abnormality of calcium-phosphate metabolism (HP:0100530)4.73553536
6Visual hallucinations (HP:0002367)4.51092954
7Agitation (HP:0000713)4.05550307
8Myokymia (HP:0002411)4.04627720
9Hypoglycemic coma (HP:0001325)4.03183050
10Polyphagia (HP:0002591)3.91181682
11Diplopia (HP:0000651)3.61997971
12Abnormality of binocular vision (HP:0011514)3.61997971
13Pheochromocytoma (HP:0002666)3.60917758
14Spastic gait (HP:0002064)3.57344063
15Late onset (HP:0003584)3.52600590
16Focal motor seizures (HP:0011153)3.51221822
17Mutism (HP:0002300)3.43471935
18Abnormality of endocrine pancreas physiology (HP:0012093)3.40825498
19Abnormality of the pancreatic islet cells (HP:0006476)3.40825498
20Hyperglycemia (HP:0003074)3.40554814
21Ketoacidosis (HP:0001993)3.38361867
22Supranuclear gaze palsy (HP:0000605)3.33674082
23Retinal atrophy (HP:0001105)3.23787468
24Large for gestational age (HP:0001520)3.20492620
25Neuroendocrine neoplasm (HP:0100634)3.15783393
26Depression (HP:0000716)3.15634090
27Menstrual irregularities (HP:0000858)3.15505299
28Hyperparathyroidism (HP:0000843)3.14158339
29Hypercortisolism (HP:0001578)3.13041901
30Urinary bladder sphincter dysfunction (HP:0002839)3.12495031
31Insulin-resistant diabetes mellitus (HP:0000831)3.11682099
32Akinesia (HP:0002304)3.09030050
33Pancreatic islet-cell hyperplasia (HP:0004510)3.08768045
34Intention tremor (HP:0002080)3.05921623
35Papilledema (HP:0001085)3.02816330
36Cerebral hypomyelination (HP:0006808)3.01424815
37Amblyopia (HP:0000646)2.99235941
38Anxiety (HP:0000739)2.98318195
39Urinary urgency (HP:0000012)2.86696775
40Impaired vibration sensation in the lower limbs (HP:0002166)2.85250975
41EEG with generalized epileptiform discharges (HP:0011198)2.84926453
42Decreased circulating renin level (HP:0003351)2.84455112
43Sleep apnea (HP:0010535)2.81846066
44Focal seizures (HP:0007359)2.81786500
45Epileptiform EEG discharges (HP:0011182)2.78495240
46Hypsarrhythmia (HP:0002521)2.78368398
47Delusions (HP:0000746)2.77013049
48Abnormality of the corticospinal tract (HP:0002492)2.76137756
49Ankle clonus (HP:0011448)2.76038708
50Atonic seizures (HP:0010819)2.75772914
51Dysautonomia (HP:0002459)2.64726061
52Dysmetria (HP:0001310)2.62516440
53Dysostosis multiplex (HP:0000943)2.62414760
54Epileptic encephalopathy (HP:0200134)2.61273904
55Hyperthyroidism (HP:0000836)2.57818766
56Hemiparesis (HP:0001269)2.55537050
57Craniofacial dystonia (HP:0012179)2.52000110
58Status epilepticus (HP:0002133)2.49636750
59Peripheral hypomyelination (HP:0007182)2.46329171
60Absence seizures (HP:0002121)2.46193780
61Ventricular fibrillation (HP:0001663)2.45669155
62Neurofibrillary tangles (HP:0002185)2.43895319
63Generalized tonic-clonic seizures (HP:0002069)2.43648682
64Restlessness (HP:0000711)2.41986701
65Growth hormone excess (HP:0000845)2.40844756
66Obstructive sleep apnea (HP:0002870)2.38189172
67Abnormal pancreas size (HP:0012094)2.37277298
68Neuronal loss in central nervous system (HP:0002529)2.37152920
69Lower limb muscle weakness (HP:0007340)2.36141404
70Congenital malformation of the right heart (HP:0011723)2.35041280
71Double outlet right ventricle (HP:0001719)2.35041280
72Action tremor (HP:0002345)2.32455469
73Annular pancreas (HP:0001734)2.32175747
74Progressive cerebellar ataxia (HP:0002073)2.31380379
75Drooling (HP:0002307)2.31241050
76Failure to thrive in infancy (HP:0001531)2.30731945
77Adrenal overactivity (HP:0002717)2.29497607
78Poor eye contact (HP:0000817)2.28082871
79Neoplasm of the heart (HP:0100544)2.26236463
80Mucopolysacchariduria (HP:0008155)2.24813119
81Urinary glycosaminoglycan excretion (HP:0003541)2.24813119
82Increased circulating renin level (HP:0000848)2.24266684
83Apathy (HP:0000741)2.21592097
84Degeneration of the lateral corticospinal tracts (HP:0002314)2.21314509
85Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.21314509
86Type II lissencephaly (HP:0007260)2.20381281
87Tetraplegia (HP:0002445)2.19689512
88Poor suck (HP:0002033)2.18495711
89Truncal ataxia (HP:0002078)2.17691383
90Hypokalemia (HP:0002900)2.17605597
91Hemiplegia (HP:0002301)2.16112806
92Limb dystonia (HP:0002451)2.14396460
93Hypotension (HP:0002615)2.14275684
94Morphological abnormality of the pyramidal tract (HP:0002062)2.13788805
95Dysdiadochokinesis (HP:0002075)2.13471982
96Dialeptic seizures (HP:0011146)2.11869293
97Abnormality of mucopolysaccharide metabolism (HP:0011020)2.11792751
98Abnormality of polysaccharide metabolism (HP:0011012)2.11792751
99Abnormality of glycosaminoglycan metabolism (HP:0004371)2.11792751
100Excessive salivation (HP:0003781)2.10680571
101Abnormality of renin-angiotensin system (HP:0000847)2.10099284
102Febrile seizures (HP:0002373)2.09971209
103Cerebral inclusion bodies (HP:0100314)2.09032136
104Diminished motivation (HP:0000745)2.07856985
105Broad-based gait (HP:0002136)2.07670050
106Amyotrophic lateral sclerosis (HP:0007354)2.07290104
107Abnormality of the lower motor neuron (HP:0002366)2.06976108
108Psychosis (HP:0000709)2.06961820
109Hypoventilation (HP:0002791)2.06167390
110Orthostatic hypotension (HP:0001278)2.04660449
111Abnormality of aromatic amino acid family metabolism (HP:0004338)2.03869038
112Fetal akinesia sequence (HP:0001989)2.03504456
113Torticollis (HP:0000473)2.02196790
114Postural tremor (HP:0002174)2.01640389
115Impaired smooth pursuit (HP:0007772)2.01382830
116Hyperphosphatemia (HP:0002905)2.01364867
117Spastic tetraplegia (HP:0002510)2.01252656
118Hypothermia (HP:0002045)2.00606440
119Hyperkalemia (HP:0002153)2.00332187
120Absent speech (HP:0001344)1.98202934
121Retinal dysplasia (HP:0007973)1.95987544
122Macroorchidism (HP:0000053)1.94552186
123Impaired social interactions (HP:0000735)1.94303466
124Abnormal social behavior (HP:0012433)1.94303466
125Focal dystonia (HP:0004373)1.94230516
126Cortical visual impairment (HP:0100704)1.93959776
127Spastic tetraparesis (HP:0001285)1.93834130
128Hyperventilation (HP:0002883)1.93231427
129Progressive neurologic deterioration (HP:0002344)1.92944363
130CNS hypomyelination (HP:0003429)1.92846344
131Gait imbalance (HP:0002141)1.92651880
132Split foot (HP:0001839)1.92240898
133Megalencephaly (HP:0001355)1.91685591
134Rigidity (HP:0002063)1.91140308
135Abnormality of potassium homeostasis (HP:0011042)1.90003400
136Truncus arteriosus (HP:0001660)1.88330669
137Clonus (HP:0002169)1.88183539
138Blue irides (HP:0000635)1.86856550
139Testicular neoplasm (HP:0010788)1.86127588
140Postural instability (HP:0002172)1.85726798
141Choreoathetosis (HP:0001266)1.85286264
142Gout (HP:0001997)1.84653903
143Hypoplasia of the corpus callosum (HP:0002079)1.84572489
144Prominent metopic ridge (HP:0005487)1.84426229
145Neoplasm of the peripheral nervous system (HP:0100007)1.84384616
146Bundle branch block (HP:0011710)1.83980773
147Prolonged QT interval (HP:0001657)1.83201429
148Insomnia (HP:0100785)1.81941033
149Congenital glaucoma (HP:0001087)1.81760737
150Abnormal eating behavior (HP:0100738)1.80985873
151Impaired vibratory sensation (HP:0002495)1.80928141
152Muscular hypotonia of the trunk (HP:0008936)1.80407627
153Incomplete penetrance (HP:0003829)1.79466935
154Specific learning disability (HP:0001328)1.79372889
155Insulin resistance (HP:0000855)1.77699579
156Bradykinesia (HP:0002067)1.77120772
157Abnormal EKG (HP:0003115)1.76793851
158Ketosis (HP:0001946)1.76727871
159Stereotypic behavior (HP:0000733)1.73577746
160Diminished movement (HP:0002374)1.73450608
161Rapidly progressive (HP:0003678)1.72544045

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.48061222
2WNK34.81272682
3INSRR3.84440673
4NTRK33.46330898
5PRKD32.78693541
6NTRK12.76658353
7MAP3K92.73281157
8UHMK12.69928943
9PASK2.45024659
10WNK42.26427741
11MAP3K22.14776855
12EPHA42.04587572
13KSR22.02100231
14PLK21.77979472
15HIPK21.77418697
16PAK61.76365043
17MINK11.76306657
18PIK3CG1.65707931
19MARK11.62891690
20DAPK21.60950549
21CAMKK21.59847671
22SIK21.54496026
23ARAF1.51430615
24MAP3K11.49323554
25MAP3K41.48610900
26FRK1.46327348
27NTRK21.36307698
28CAMKK11.35359122
29PAK31.33767153
30WNK11.30987445
31CDK51.24654919
32DYRK21.21634812
33MAP2K71.16560153
34GRK51.11975802
35PINK11.11414210
36PRKCH1.07666225
37SCYL21.07521277
38TAOK31.05567329
39PKN11.02600756
40MAP3K121.01345153
41DAPK11.01283121
42CSNK1G30.96436778
43BRAF0.93173919
44MAP3K110.92616982
45PRKCG0.91911163
46MAP2K40.91834039
47CDC42BPA0.87677734
48KSR10.86413397
49CSNK1A1L0.83660243
50STK110.83569147
51ERN10.82700089
52PRKD20.79841299
53STK380.78416953
54DYRK1B0.77619206
55FER0.77086655
56PTK20.76972509
57TAOK10.76056787
58MAPK120.74207162
59SGK20.73259716
60ALK0.71141757
61RET0.70738551
62PDGFRA0.70492436
63PHKG10.69330306
64PHKG20.69330306
65BRSK10.68364901
66SGK2230.66614263
67SGK4940.66614263
68CSNK1G10.65907679
69FGFR20.64359667
70LIMK10.64153369
71MARK20.63903571
72DYRK1A0.63252488
73CDK140.62664725
74MAP3K130.62354612
75TNK20.60773399
76CDK190.60541141
77RIPK40.60065526
78CAMK2B0.59647469
79MAPK130.57526683
80CAMK40.55493867
81PNCK0.55476377
82CAMK10.55429590
83LATS20.55043604
84TESK10.54786166
85SGK30.54308737
86CAMK2A0.53671135
87MAP4K20.52977512
88MAP2K60.52754382
89CAMK2D0.52594952
90TNIK0.52527139
91MAP2K10.52171044
92FES0.50627305
93CDK180.49733144
94PRKCE0.49482981
95CDK150.48892572
96ICK0.47932529
97CDK11A0.45441029
98PDPK10.42766389
99PDK10.42115778
100MAPK100.41090367
101ROCK20.40974739
102SGK10.40883390
103MAP2K20.40691432
104EPHA30.40080335
105LMTK20.39959887
106OXSR10.39059645
107DAPK30.38608796
108PRKAA10.38511730
109RPS6KA30.38451803
110PRKCI0.37978338
111PRKCA0.37785870
112BCR0.37744628
113RPS6KA20.36422758
114CSNK1D0.36041182
115CSNK1G20.35710884
116RIPK10.34438814
117FLT30.33858154
118CSNK1E0.33671429
119PRKACG0.32956655
120NEK60.32740725
121ADRBK10.32729775
122ERBB20.31770339
123MAPK80.31575679
124CSNK1A10.31479433
125CAMK2G0.30975453
126PRKACA0.30518008
127PRPF4B0.29933262
128CASK0.29250736
129PRKCZ0.28476892
130CAMK1G0.28363790
131TYRO30.27121762

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.20063775
2Insulin secretion_Homo sapiens_hsa049113.43709666
3Synaptic vesicle cycle_Homo sapiens_hsa047212.97645652
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.53771665
5GABAergic synapse_Homo sapiens_hsa047272.31142017
6Protein export_Homo sapiens_hsa030602.28704409
7Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.28123590
8Circadian entrainment_Homo sapiens_hsa047132.22532752
9Amphetamine addiction_Homo sapiens_hsa050312.22117257
10Cocaine addiction_Homo sapiens_hsa050302.21672390
11Vibrio cholerae infection_Homo sapiens_hsa051102.04505052
12Type II diabetes mellitus_Homo sapiens_hsa049302.03943365
13Long-term potentiation_Homo sapiens_hsa047201.99398191
14Nicotine addiction_Homo sapiens_hsa050331.95074328
15Dopaminergic synapse_Homo sapiens_hsa047281.90348222
16Type I diabetes mellitus_Homo sapiens_hsa049401.86870891
17Morphine addiction_Homo sapiens_hsa050321.81338546
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.79367187
19Olfactory transduction_Homo sapiens_hsa047401.77859071
20Taste transduction_Homo sapiens_hsa047421.74364764
21Glutamatergic synapse_Homo sapiens_hsa047241.69643632
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65463175
23Vitamin B6 metabolism_Homo sapiens_hsa007501.61923574
24Cholinergic synapse_Homo sapiens_hsa047251.60723745
25Serotonergic synapse_Homo sapiens_hsa047261.47330299
26Collecting duct acid secretion_Homo sapiens_hsa049661.44230387
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43194769
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.42666956
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.41109753
30Gastric acid secretion_Homo sapiens_hsa049711.37915323
31Salivary secretion_Homo sapiens_hsa049701.37375161
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.29123136
33Renin secretion_Homo sapiens_hsa049241.28538014
34Estrogen signaling pathway_Homo sapiens_hsa049151.17824035
35Long-term depression_Homo sapiens_hsa047301.16901068
36Pancreatic secretion_Homo sapiens_hsa049721.16607995
37Prion diseases_Homo sapiens_hsa050201.08770681
38Circadian rhythm_Homo sapiens_hsa047101.08506978
39Oxytocin signaling pathway_Homo sapiens_hsa049211.07104954
40Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.06392672
41Thyroid hormone synthesis_Homo sapiens_hsa049181.06310212
42GnRH signaling pathway_Homo sapiens_hsa049121.04931566
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03229167
44Glucagon signaling pathway_Homo sapiens_hsa049221.02071383
45cAMP signaling pathway_Homo sapiens_hsa040241.02029350
46Gap junction_Homo sapiens_hsa045401.01149954
47Sulfur metabolism_Homo sapiens_hsa009201.00443127
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98479405
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97804074
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94473901
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.94333132
52Lysosome_Homo sapiens_hsa041420.93995786
53Calcium signaling pathway_Homo sapiens_hsa040200.91569807
54SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90535685
55N-Glycan biosynthesis_Homo sapiens_hsa005100.88035585
56Regulation of autophagy_Homo sapiens_hsa041400.83402034
57Melanogenesis_Homo sapiens_hsa049160.81983750
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80209439
59Alcoholism_Homo sapiens_hsa050340.79750121
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79451751
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79163349
62Nitrogen metabolism_Homo sapiens_hsa009100.76502042
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74171503
64Dorso-ventral axis formation_Homo sapiens_hsa043200.72047475
65Cardiac muscle contraction_Homo sapiens_hsa042600.71076339
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68370545
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66517155
68Glioma_Homo sapiens_hsa052140.65322431
69Arginine and proline metabolism_Homo sapiens_hsa003300.62172026
70Insulin signaling pathway_Homo sapiens_hsa049100.61355689
71ErbB signaling pathway_Homo sapiens_hsa040120.60614246
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.58347546
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54007132
74Rap1 signaling pathway_Homo sapiens_hsa040150.53726875
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.53628504
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.53158101
77Alzheimers disease_Homo sapiens_hsa050100.52036565
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51679500
79Prolactin signaling pathway_Homo sapiens_hsa049170.51346385
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50294607
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47850017
82VEGF signaling pathway_Homo sapiens_hsa043700.47598216
83Oocyte meiosis_Homo sapiens_hsa041140.47132346
84AMPK signaling pathway_Homo sapiens_hsa041520.46896383
85Endocytosis_Homo sapiens_hsa041440.46731158
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.46347241
87beta-Alanine metabolism_Homo sapiens_hsa004100.46240351
88Oxidative phosphorylation_Homo sapiens_hsa001900.45963041
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44570197
90Other glycan degradation_Homo sapiens_hsa005110.42761931
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41674637
92Axon guidance_Homo sapiens_hsa043600.41333926
93Butanoate metabolism_Homo sapiens_hsa006500.41029783
94Arginine biosynthesis_Homo sapiens_hsa002200.38422943
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37919794
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37122424
97Bile secretion_Homo sapiens_hsa049760.35828230
98Dilated cardiomyopathy_Homo sapiens_hsa054140.35414892
99Parkinsons disease_Homo sapiens_hsa050120.35006263
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34927207
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34494492
102Histidine metabolism_Homo sapiens_hsa003400.34021206
103Choline metabolism in cancer_Homo sapiens_hsa052310.33939127
104Inositol phosphate metabolism_Homo sapiens_hsa005620.33845379
105Wnt signaling pathway_Homo sapiens_hsa043100.33475799
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.33354277
107Ovarian steroidogenesis_Homo sapiens_hsa049130.31755934
108Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31610275
109mTOR signaling pathway_Homo sapiens_hsa041500.30473676
110MAPK signaling pathway_Homo sapiens_hsa040100.30286840
111Ras signaling pathway_Homo sapiens_hsa040140.30193112
112Renal cell carcinoma_Homo sapiens_hsa052110.29817182
113Hippo signaling pathway_Homo sapiens_hsa043900.29399708
114Insulin resistance_Homo sapiens_hsa049310.28074275
115Phototransduction_Homo sapiens_hsa047440.27980076
116Folate biosynthesis_Homo sapiens_hsa007900.27605012
117ABC transporters_Homo sapiens_hsa020100.26097078
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.23245374

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