PCSK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The protein undergoes an initial autocatalytic processing event and interacts with a neuroendocrine secretory protein in the ER, exits the ER and sorts to secretory granules, where it is cleaved and catalytically activated during intracellular transport. The encoded protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)9.13019166
2COPI coating of Golgi vesicle (GO:0048205)9.13019166
3endocrine pancreas development (GO:0031018)6.01010090
4retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.81036948
5protein maturation by protein folding (GO:0022417)5.67069849
6maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.57528706
7COPII vesicle coating (GO:0048208)5.30675902
8* peptide hormone processing (GO:0016486)5.29176792
9insulin secretion (GO:0030073)5.09101033
10positive regulation of insulin secretion (GO:0032024)5.06824192
11glandular epithelial cell differentiation (GO:0002067)5.01339277
12protein retention in ER lumen (GO:0006621)4.89751966
13regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.86834242
14regulation of type B pancreatic cell apoptotic process (GO:2000674)4.78038506
15glycerophospholipid catabolic process (GO:0046475)4.72746146
16detection of calcium ion (GO:0005513)4.69281098
17regulation of insulin secretion (GO:0050796)4.47946750
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.44518961
19type B pancreatic cell development (GO:0003323)4.39201529
20negative regulation of execution phase of apoptosis (GO:1900118)4.35027081
21vesicle coating (GO:0006901)4.33456997
22L-alpha-amino acid transmembrane transport (GO:1902475)4.30780595
23signal peptide processing (GO:0006465)4.29351684
24activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.21966604
25glandular epithelial cell development (GO:0002068)4.20472359
26positive regulation of peptide hormone secretion (GO:0090277)4.15506956
27inositol phosphate catabolic process (GO:0071545)4.11463246
28sequestering of metal ion (GO:0051238)4.10121428
29regulation of peptide hormone secretion (GO:0090276)4.09147866
30positive regulation of peptide secretion (GO:0002793)4.05983707
31regulation of peptide secretion (GO:0002791)4.03070562
32positive regulation of nuclease activity (GO:0032075)3.96947248
33ER overload response (GO:0006983)3.95452714
34peptide hormone secretion (GO:0030072)3.93487312
35positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.90953476
36inositol phosphate dephosphorylation (GO:0046855)3.88613740
37phosphorylated carbohydrate dephosphorylation (GO:0046838)3.88613740
38intra-Golgi vesicle-mediated transport (GO:0006891)3.83994368
39dendritic spine morphogenesis (GO:0060997)3.83856566
40exocrine pancreas development (GO:0031017)3.83413996
41peptide secretion (GO:0002790)3.83117464
42cellular ketone body metabolic process (GO:0046950)3.81690928
43toxin metabolic process (GO:0009404)3.74337111
44positive regulation of gluconeogenesis (GO:0045722)3.71601373
45auditory receptor cell differentiation (GO:0042491)3.69572104
46response to dietary excess (GO:0002021)3.63874683
47nitric oxide mediated signal transduction (GO:0007263)3.63610749
48negative regulation of cytosolic calcium ion concentration (GO:0051481)3.59077139
49regulation of nuclease activity (GO:0032069)3.58903088
50regulation of hormone secretion (GO:0046883)3.58892459
51nitric oxide biosynthetic process (GO:0006809)3.58297573
52cellular response to glucagon stimulus (GO:0071377)3.54545392
53positive regulation of vesicle fusion (GO:0031340)3.41595504
54endoplasmic reticulum unfolded protein response (GO:0030968)3.40582923
55regulation of calcium ion-dependent exocytosis (GO:0017158)3.38678715
56ketone body metabolic process (GO:1902224)3.38322337
57nodal signaling pathway (GO:0038092)3.38114564
58cellular response to unfolded protein (GO:0034620)3.35756981
59protein localization to Golgi apparatus (GO:0034067)3.33074929
60positive regulation of histone H3-K4 methylation (GO:0051571)3.32036011
61ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.31770352
62regulation of glucocorticoid secretion (GO:2000849)3.30883932
63cellular response to topologically incorrect protein (GO:0035967)3.30684485
64regulation of peptide transport (GO:0090087)3.28387431
65regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)3.27648552
66positive regulation of hormone secretion (GO:0046887)3.27172462
67chemosensory behavior (GO:0007635)3.25720156
68epithelial cell fate commitment (GO:0072148)3.25195010
69cellular response to vitamin D (GO:0071305)3.24621229
70regulation of hexokinase activity (GO:1903299)3.20768192
71regulation of glucokinase activity (GO:0033131)3.20768192
72negative regulation of catecholamine secretion (GO:0033604)3.20607672
73ER-nucleus signaling pathway (GO:0006984)3.20538349
74columnar/cuboidal epithelial cell development (GO:0002066)3.18723207
75macroautophagy (GO:0016236)3.18323604
76negative regulation of glycoprotein biosynthetic process (GO:0010561)3.17367223
77protein targeting to Golgi (GO:0000042)3.15928589
78regulation of synaptic vesicle exocytosis (GO:2000300)3.15685649
79cerebellar Purkinje cell layer development (GO:0021680)3.14306398
80water-soluble vitamin biosynthetic process (GO:0042364)3.12628272
81polyol catabolic process (GO:0046174)3.12524524
82proline transport (GO:0015824)3.11739872
83hormone secretion (GO:0046879)3.11660744
84ER to Golgi vesicle-mediated transport (GO:0006888)3.11280718
85positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.09940079
86negative regulation of insulin secretion (GO:0046676)3.09257370
87respiratory chain complex IV assembly (GO:0008535)3.09177885
88negative regulation of JUN kinase activity (GO:0043508)3.05706202
89inner ear receptor cell development (GO:0060119)3.05371331
90membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.05075082
91peptide transport (GO:0015833)3.04533194
92astrocyte differentiation (GO:0048708)3.00521848
93negative regulation of norepinephrine secretion (GO:0010700)2.99734900
94growth hormone secretion (GO:0030252)2.99452850
95positive regulation of exocytosis (GO:0045921)2.98403627
96regulation of neurotransmitter uptake (GO:0051580)2.97936654
97positive regulation of synaptic transmission, GABAergic (GO:0032230)2.97518247
98regulation of norepinephrine secretion (GO:0014061)2.96133024
99hormone transport (GO:0009914)2.95676548
100cytochrome complex assembly (GO:0017004)2.94883833
101protein N-linked glycosylation via asparagine (GO:0018279)2.94163277
102positive regulation of neurotransmitter transport (GO:0051590)2.93793110
103positive regulation of calcium ion import (GO:0090280)2.93074622
104peptidyl-asparagine modification (GO:0018196)2.91926877
105glutamate secretion (GO:0014047)2.85869992
106cellular zinc ion homeostasis (GO:0006882)2.85087058
107L-phenylalanine catabolic process (GO:0006559)2.84850094
108erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.84850094
109response to endoplasmic reticulum stress (GO:0034976)2.83683989
110alanine transport (GO:0032328)2.82509346
111regulation of extracellular matrix disassembly (GO:0010715)2.80110812
112activation of protein kinase A activity (GO:0034199)2.79374246
113regulation of short-term neuronal synaptic plasticity (GO:0048172)2.78232305
114regulation of synaptic vesicle transport (GO:1902803)2.77153355
115L-phenylalanine metabolic process (GO:0006558)2.76284725
116erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.76284725
117negative regulation of peptide hormone secretion (GO:0090278)2.75649286
118regulation of Rac protein signal transduction (GO:0035020)2.75497078
119phenylpropanoid metabolic process (GO:0009698)2.75277190
120establishment of protein localization to Golgi (GO:0072600)2.74170892
121Golgi organization (GO:0007030)2.72504169
122regulation of vesicle fusion (GO:0031338)2.71314660
123membrane repolarization during action potential (GO:0086011)2.70937566
124neuromuscular process controlling posture (GO:0050884)2.70278943
125Golgi vesicle transport (GO:0048193)2.70105146
126synaptic vesicle maturation (GO:0016188)2.70090906
127regulation of beta-amyloid formation (GO:1902003)2.68090650
128response to ischemia (GO:0002931)2.67933214
129protein N-linked glycosylation (GO:0006487)2.67900458
130response to hexose (GO:0009746)2.67747293
131response to hepatocyte growth factor (GO:0035728)2.67488745
132cellular response to hepatocyte growth factor stimulus (GO:0035729)2.67488745
133regulation of execution phase of apoptosis (GO:1900117)2.67154562
134magnesium ion transport (GO:0015693)2.66702289
135negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.65934994
136response to glucose (GO:0009749)2.64654063
137retrograde transport, vesicle recycling within Golgi (GO:0000301)2.64617652
138axoneme assembly (GO:0035082)2.63374289
139regulation of autophagic vacuole assembly (GO:2000785)2.61435825
140positive regulation of macroautophagy (GO:0016239)2.60801751
141neurotransmitter secretion (GO:0007269)2.60709074
142synaptic vesicle docking involved in exocytosis (GO:0016081)2.59880385
143brain morphogenesis (GO:0048854)2.59648652
144calcium ion import (GO:0070509)2.59306418
145zinc ion homeostasis (GO:0055069)2.53770955
146positive regulation of glycolytic process (GO:0045821)2.50131156
147retinol metabolic process (GO:0042572)2.49927098
148regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.49794292
149regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.49794292
150protein localization to cilium (GO:0061512)2.49366755
151regulation of heart rate by cardiac conduction (GO:0086091)2.48504369
152potassium ion export (GO:0071435)2.48216385
153negative regulation of hormone biosynthetic process (GO:0032353)2.48148375
154dentate gyrus development (GO:0021542)2.47413267
155regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.47094294
156phospholipid catabolic process (GO:0009395)2.46256581
157catecholamine transport (GO:0051937)2.42017905
158positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.40541406
159regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.39967365
160nephron tubule morphogenesis (GO:0072078)2.37726897
161nephron epithelium morphogenesis (GO:0072088)2.37726897
162positive regulation of meiosis (GO:0045836)2.37699225
163renal tubule morphogenesis (GO:0061333)2.36838407
164inositol phosphate-mediated signaling (GO:0048016)2.36227051
165basic amino acid transport (GO:0015802)2.35550721
166signal release (GO:0023061)2.35294626
167regulation of vacuole organization (GO:0044088)2.34165110

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.27120687
2GATA1_22025678_ChIP-Seq_K562_Human3.16209923
3DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.73580740
4* REST_21632747_ChIP-Seq_MESCs_Mouse2.69602893
5* FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.68847205
6PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.66009556
7IGF1R_20145208_ChIP-Seq_DFB_Human2.39055752
8* REST_18959480_ChIP-ChIP_MESCs_Mouse2.29005110
9NR3C1_23031785_ChIP-Seq_PC12_Mouse2.11790363
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11752089
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.09778835
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.05988264
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.98545047
14* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.96707686
15FLI1_27457419_Chip-Seq_LIVER_Mouse1.96439198
16TAF15_26573619_Chip-Seq_HEK293_Human1.92195735
17* RARB_27405468_Chip-Seq_BRAIN_Mouse1.91804663
18* GBX2_23144817_ChIP-Seq_PC3_Human1.89016228
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85255233
20* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.80554457
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.80371779
22FUS_26573619_Chip-Seq_HEK293_Human1.77933506
23ZNF274_21170338_ChIP-Seq_K562_Hela1.75058680
24VDR_22108803_ChIP-Seq_LS180_Human1.74946698
25EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.70170605
26HTT_18923047_ChIP-ChIP_STHdh_Human1.68471458
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66223047
28* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.65762525
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.64264888
30DROSHA_22980978_ChIP-Seq_HELA_Human1.64191400
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.63058545
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60146508
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59103281
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.57245209
35OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.56113147
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55155505
37STAT3_23295773_ChIP-Seq_U87_Human1.54536148
38CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.53836495
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53042038
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52847709
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52552321
42ER_23166858_ChIP-Seq_MCF-7_Human1.49692970
43* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49536199
44SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.47636377
45* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47355982
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.45246426
47REST_19997604_ChIP-ChIP_NEURONS_Mouse1.44233392
48* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44074349
49* SMAD4_21799915_ChIP-Seq_A2780_Human1.43518557
50JARID2_20064375_ChIP-Seq_MESCs_Mouse1.39921491
51* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37312669
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36595225
53* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35167714
54PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.32029953
55* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31261303
56GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30775973
57SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.30584390
58* P53_22387025_ChIP-Seq_ESCs_Mouse1.30272194
59* SOX2_21211035_ChIP-Seq_LN229_Gbm1.29748545
60ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29039500
61SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.28277996
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25999496
63EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.25533676
64RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23742304
65RNF2_27304074_Chip-Seq_ESCs_Mouse1.23726449
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23227897
67CBP_20019798_ChIP-Seq_JUKART_Human1.23227897
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22695021
69CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22542762
70* STAT3_18555785_Chip-Seq_ESCs_Mouse1.21945411
71RNF2_27304074_Chip-Seq_NSC_Mouse1.19879677
72* SOX2_18555785_Chip-Seq_ESCs_Mouse1.19400045
73YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18905882
74* CMYC_18555785_Chip-Seq_ESCs_Mouse1.18865159
75* FOXA1_25329375_ChIP-Seq_VCAP_Human1.18858942
76* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18858942
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.18647859
78CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.18338594
79* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17795022
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.17483595
81NANOG_19829295_ChIP-Seq_ESCs_Human1.17369587
82SOX2_19829295_ChIP-Seq_ESCs_Human1.17369587
83* E2F1_18555785_Chip-Seq_ESCs_Mouse1.17245727
84* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17015806
85TP53_22573176_ChIP-Seq_HFKS_Human1.16419170
86SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16273090
87ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15965351
88TCF4_22108803_ChIP-Seq_LS180_Human1.15873996
89TCF4_23295773_ChIP-Seq_U87_Human1.14181483
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12835615
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12614325
92FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.12128496
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10807767
94LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10364707
95EED_16625203_ChIP-ChIP_MESCs_Mouse1.10259076
96PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10033384
97EWS_26573619_Chip-Seq_HEK293_Human1.10020725
98CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09599447
99* AR_19668381_ChIP-Seq_PC3_Human1.09112622
100* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08052424
101BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07989110
102TAL1_26923725_Chip-Seq_HPCs_Mouse1.07522897
103CDX2_22108803_ChIP-Seq_LS180_Human1.07141903
104SMAD3_21741376_ChIP-Seq_ESCs_Human1.07135239
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06768597
106SMAD4_21741376_ChIP-Seq_EPCs_Human1.06529169
107FLI1_21867929_ChIP-Seq_TH2_Mouse1.06203275
108ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05062252
109* NMYC_18555785_Chip-Seq_ESCs_Mouse1.04950316
110* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04607964
111* CTCF_18555785_Chip-Seq_ESCs_Mouse1.03965925
112* P300_18555785_Chip-Seq_ESCs_Mouse1.03872282
113CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03025282
114EZH2_18974828_ChIP-Seq_MESCs_Mouse1.02966591
115RNF2_18974828_ChIP-Seq_MESCs_Mouse1.02966591
116ARNT_22903824_ChIP-Seq_MCF-7_Human1.02635131
117FOXA1_25552417_ChIP-Seq_VCAP_Human1.02381480
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02370417
119BCAT_22108803_ChIP-Seq_LS180_Human1.01587000
120ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01119728
121SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00106640
122DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99122751
123* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98873577
124* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.98713090
125RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96704611
126RUNX2_22187159_ChIP-Seq_PCA_Human0.96322351
127SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95974093
128* P300_19829295_ChIP-Seq_ESCs_Human0.95714412
129AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95444216
130* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93847704
131IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92806320
132ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90694591
133* NANOG_18555785_Chip-Seq_ESCs_Mouse0.89734272
134AR_25329375_ChIP-Seq_VCAP_Human0.88121230
135ETV2_25802403_ChIP-Seq_MESCs_Mouse0.86212930
136STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85553935
137GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82929260
138TDRD3_21172665_ChIP-Seq_MCF-7_Human0.82524515
139EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.82279287
140NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81941581
141TET1_21490601_ChIP-Seq_MESCs_Mouse0.81536323
142FOXA1_21572438_ChIP-Seq_LNCaP_Human0.80336788
143FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.80166636
144* SMAD3_21741376_ChIP-Seq_EPCs_Human0.79423512
145PKCTHETA_26484144_Chip-Seq_BREAST_Human0.77942986
146FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77765224

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000013_abnormal_adipose_tissue4.89613549
2MP0002909_abnormal_adrenal_gland4.46993167
3MP0003283_abnormal_digestive_organ4.05423732
4MP0002877_abnormal_melanocyte_morpholog4.01617332
5MP0003183_abnormal_peptide_metabolism3.94542674
6MP0003195_calcinosis3.76171169
7MP0009780_abnormal_chondrocyte_physiolo3.73378963
8MP0004043_abnormal_pH_regulation3.66249735
9* MP0002693_abnormal_pancreas_physiology3.50848854
10MP0010386_abnormal_urinary_bladder3.32600027
11* MP0001944_abnormal_pancreas_morphology3.26486508
12MP0002837_dystrophic_cardiac_calcinosis3.09921522
13MP0005645_abnormal_hypothalamus_physiol2.89907812
14MP0000678_abnormal_parathyroid_gland2.88437382
15MP0000003_abnormal_adipose_tissue2.47747045
16MP0003122_maternal_imprinting2.38070967
17MP0008877_abnormal_DNA_methylation2.36510024
18MP0005220_abnormal_exocrine_pancreas2.23693693
19MP0001986_abnormal_taste_sensitivity2.11139313
20* MP0002078_abnormal_glucose_homeostasis2.07880891
21MP0006072_abnormal_retinal_apoptosis2.04210519
22MP0005646_abnormal_pituitary_gland2.00537739
23MP0002638_abnormal_pupillary_reflex1.98772772
24MP0002139_abnormal_hepatobiliary_system1.96267443
25MP0010234_abnormal_vibrissa_follicle1.94047502
26* MP0005379_endocrine/exocrine_gland_phen1.73776071
27MP0001765_abnormal_ion_homeostasis1.66349873
28MP0004019_abnormal_vitamin_homeostasis1.66132743
29MP0002163_abnormal_gland_morphology1.63401777
30MP0004859_abnormal_synaptic_plasticity1.60166919
31MP0008961_abnormal_basal_metabolism1.59754995
32MP0010329_abnormal_lipoprotein_level1.59636218
33MP0003011_delayed_dark_adaptation1.58558341
34MP0002254_reproductive_system_inflammat1.58149844
35MP0004133_heterotaxia1.57290743
36MP0002234_abnormal_pharynx_morphology1.56089144
37MP0004264_abnormal_extraembryonic_tissu1.56059134
38MP0005551_abnormal_eye_electrophysiolog1.55480049
39MP0003172_abnormal_lysosome_physiology1.55134887
40MP0003635_abnormal_synaptic_transmissio1.51531689
41MP0005332_abnormal_amino_acid1.51103852
42MP0004885_abnormal_endolymph1.45721586
43MP0003787_abnormal_imprinting1.38950195
44* MP0003953_abnormal_hormone_level1.32470262
45MP0001502_abnormal_circadian_rhythm1.30304895
46MP0002896_abnormal_bone_mineralization1.30189016
47MP0001905_abnormal_dopamine_level1.30060057
48MP0000631_abnormal_neuroendocrine_gland1.27570636
49MP0002928_abnormal_bile_duct1.25191527
50MP0001968_abnormal_touch/_nociception1.23733150
51MP0002572_abnormal_emotion/affect_behav1.23558990
52MP0003879_abnormal_hair_cell1.20632068
53MP0003959_abnormal_lean_body1.20547925
54MP0005535_abnormal_body_temperature1.19259909
55MP0002272_abnormal_nervous_system1.14896107
56MP0001756_abnormal_urination1.14882808
57MP0002063_abnormal_learning/memory/cond1.14197609
58MP0004145_abnormal_muscle_electrophysio1.11099335
59MP0000462_abnormal_digestive_system1.10349154
60MP0002876_abnormal_thyroid_physiology1.07521886
61* MP0002734_abnormal_mechanical_nocicepti1.06825677
62MP0000613_abnormal_salivary_gland1.05684197
63MP0002064_seizures1.05625649
64MP0003300_gastrointestinal_ulcer1.04743573
65MP0009745_abnormal_behavioral_response1.04553007
66MP0003868_abnormal_feces_composition1.04469845
67MP0004142_abnormal_muscle_tone1.03908016
68* MP0002733_abnormal_thermal_nociception1.00233813
69MP0005375_adipose_tissue_phenotype0.98993617
70MP0000427_abnormal_hair_cycle0.98603592
71MP0005248_abnormal_Harderian_gland0.98279810
72MP0002557_abnormal_social/conspecific_i0.97006953
73MP0005058_abnormal_lysosome_morphology0.96719613
74MP0000955_abnormal_spinal_cord0.93620764
75MP0005257_abnormal_intraocular_pressure0.92865700
76MP0005174_abnormal_tail_pigmentation0.92627192
77MP0005636_abnormal_mineral_homeostasis0.92538117
78MP0005448_abnormal_energy_balance0.91436087
79MP0000639_abnormal_adrenal_gland0.90954828
80* MP0001970_abnormal_pain_threshold0.90823030
81MP0006276_abnormal_autonomic_nervous0.90290270
82MP0002938_white_spotting0.88952992
83MP0008872_abnormal_physiological_respon0.88305332
84MP0002118_abnormal_lipid_homeostasis0.85981901
85MP0001501_abnormal_sleep_pattern0.85971942
86MP0002069_abnormal_eating/drinking_beha0.85332366
87MP0002184_abnormal_innervation0.85327431
88MP0009643_abnormal_urine_homeostasis0.84509780
89MP0003045_fibrosis0.84396805
90MP0001270_distended_abdomen0.84028200
91MP0004085_abnormal_heartbeat0.83594381
92MP0002138_abnormal_hepatobiliary_system0.83561442
93MP0001299_abnormal_eye_distance/0.83054819
94MP0003633_abnormal_nervous_system0.82611039
95MP0002090_abnormal_vision0.82320380
96MP0000569_abnormal_digit_pigmentation0.82119265
97MP0000372_irregular_coat_pigmentation0.81827916
98MP0003880_abnormal_central_pattern0.81671226
99MP0005253_abnormal_eye_physiology0.81299018
100MP0005084_abnormal_gallbladder_morpholo0.80868959
101MP0005310_abnormal_salivary_gland0.80478168
102MP0003119_abnormal_digestive_system0.79588806
103MP0001485_abnormal_pinna_reflex0.79211800
104MP0006036_abnormal_mitochondrial_physio0.79119150
105MP0002751_abnormal_autonomic_nervous0.78474881
106MP0006292_abnormal_olfactory_placode0.78392533
107MP0001188_hyperpigmentation0.77830509
108MP0003121_genomic_imprinting0.76433848
109MP0004215_abnormal_myocardial_fiber0.76028260
110* MP0004270_analgesia0.75911408
111MP0005423_abnormal_somatic_nervous0.73749964
112MP0002735_abnormal_chemical_nociception0.72993863
113MP0001984_abnormal_olfaction0.72704672
114MP0003631_nervous_system_phenotype0.72094060
115MP0004811_abnormal_neuron_physiology0.72076549
116MP0000538_abnormal_urinary_bladder0.71589723
117MP0005187_abnormal_penis_morphology0.71468782
118MP0005389_reproductive_system_phenotype0.71327316
119MP0001529_abnormal_vocalization0.71020418
120MP0002822_catalepsy0.70686606
121MP0002067_abnormal_sensory_capabilities0.70026885
122MP0001664_abnormal_digestion0.69649354
123MP0002066_abnormal_motor_capabilities/c0.67084927
124MP0002229_neurodegeneration0.66656714
125MP0005365_abnormal_bile_salt0.66563848
126MP0009046_muscle_twitch0.65762191
127MP0003123_paternal_imprinting0.65288392
128MP0000681_abnormal_thyroid_gland0.64103730
129MP0005386_behavior/neurological_phenoty0.63897748
130MP0004924_abnormal_behavior0.63897748
131MP0005452_abnormal_adipose_tissue0.62957831
132* MP0000230_abnormal_systemic_arterial0.62686209
133MP0001486_abnormal_startle_reflex0.62517061
134MP0008569_lethality_at_weaning0.61329704

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)7.73848414
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)7.38386616
3Hypoglycemic seizures (HP:0002173)6.89451144
4Symptomatic seizures (HP:0011145)6.26339462
5Hypoglycemic coma (HP:0001325)5.63216439
6Hyperglycemia (HP:0003074)5.06901864
7Abnormality of calcium-phosphate metabolism (HP:0100530)5.03203647
8Insulin-resistant diabetes mellitus (HP:0000831)4.84938498
9Pancreatic islet-cell hyperplasia (HP:0004510)4.81332910
10Abnormality of the pancreatic islet cells (HP:0006476)4.80687376
11Abnormality of endocrine pancreas physiology (HP:0012093)4.80687376
12Congenital malformation of the right heart (HP:0011723)4.50450578
13Double outlet right ventricle (HP:0001719)4.50450578
14Large for gestational age (HP:0001520)4.48469282
15Ketoacidosis (HP:0001993)4.39526965
16Late onset (HP:0003584)4.15483324
17Decreased circulating renin level (HP:0003351)3.82979177
18Agitation (HP:0000713)3.82730816
19Retinal atrophy (HP:0001105)3.49943587
20Dysostosis multiplex (HP:0000943)3.28232635
21Abnormal pancreas size (HP:0012094)3.25072800
22Mucopolysacchariduria (HP:0008155)3.17605976
23Urinary glycosaminoglycan excretion (HP:0003541)3.17605976
24Hyperparathyroidism (HP:0000843)3.15488884
25Hypokalemia (HP:0002900)3.08897346
26EEG with generalized epileptiform discharges (HP:0011198)3.06538747
27Dysautonomia (HP:0002459)3.03353911
28Abnormality of vitamin B metabolism (HP:0004340)3.02861138
29Epileptiform EEG discharges (HP:0011182)2.99954927
30Hypsarrhythmia (HP:0002521)2.99197542
31Visual hallucinations (HP:0002367)2.96478547
32Increased CSF protein (HP:0002922)2.94800261
33Abnormality of mucopolysaccharide metabolism (HP:0011020)2.93079845
34Abnormality of polysaccharide metabolism (HP:0011012)2.93079845
35Abnormality of glycosaminoglycan metabolism (HP:0004371)2.93079845
36Enlarged penis (HP:0000040)2.90455803
37Prominent metopic ridge (HP:0005487)2.89120673
38Menstrual irregularities (HP:0000858)2.80434992
39Papilledema (HP:0001085)2.78145557
40Pheochromocytoma (HP:0002666)2.77413959
41Medial flaring of the eyebrow (HP:0010747)2.71814456
42Insulin resistance (HP:0000855)2.71172577
43Abnormality of renin-angiotensin system (HP:0000847)2.70745145
44Progressive cerebellar ataxia (HP:0002073)2.70692247
45Unilateral renal agenesis (HP:0000122)2.64580825
46Abnormality of potassium homeostasis (HP:0011042)2.59768367
47Osteomalacia (HP:0002749)2.59700128
48Hyperthyroidism (HP:0000836)2.58794476
49Abnormality of vitamin metabolism (HP:0100508)2.56011855
50Hyperkalemia (HP:0002153)2.55142168
51Polyphagia (HP:0002591)2.51091391
52Hyperphosphatemia (HP:0002905)2.47572647
53Abnormality of the metopic suture (HP:0005556)2.46944880
54Neuroendocrine neoplasm (HP:0100634)2.44052885
55Congenital sensorineural hearing impairment (HP:0008527)2.41659730
56Conjugated hyperbilirubinemia (HP:0002908)2.41547783
57Progressive macrocephaly (HP:0004481)2.40806357
58Methylmalonic acidemia (HP:0002912)2.40096007
59Hypothermia (HP:0002045)2.39692364
60Increased circulating renin level (HP:0000848)2.36289070
61Hypercortisolism (HP:0001578)2.34365710
62Generalized aminoaciduria (HP:0002909)2.32361716
63Poor suck (HP:0002033)2.28594318
64Ketosis (HP:0001946)2.27750318
65Limb dystonia (HP:0002451)2.27290169
66Restlessness (HP:0000711)2.26927904
67Abnormality of the intrinsic pathway (HP:0010989)2.26464598
68Hyperventilation (HP:0002883)2.23693394
69Nephronophthisis (HP:0000090)2.23402925
70Abnormality of aromatic amino acid family metabolism (HP:0004338)2.21639259
71Hypotension (HP:0002615)2.20194937
72Pancreatic fibrosis (HP:0100732)2.19548812
73Gaze-evoked nystagmus (HP:0000640)2.19472176
74Abnormality of the renal cortex (HP:0011035)2.19394793
75Polydipsia (HP:0001959)2.19071197
76Abnormal drinking behavior (HP:0030082)2.19071197
77Progressive neurologic deterioration (HP:0002344)2.17534477
78Hyperactive renin-angiotensin system (HP:0000841)2.16886544
79Pancreatic cysts (HP:0001737)2.16787140
80Hypoplasia of the fovea (HP:0007750)2.14850303
81Aplasia/Hypoplasia of the fovea (HP:0008060)2.14850303
82Gait imbalance (HP:0002141)2.14642189
83Cortical visual impairment (HP:0100704)2.13461248
84Acute necrotizing encephalopathy (HP:0006965)2.11954363
85Abnormality of the fovea (HP:0000493)2.11499292
86Glycosuria (HP:0003076)2.09972409
87Abnormality of urine glucose concentration (HP:0011016)2.09972409
88Abnormality of midbrain morphology (HP:0002418)2.06811494
89Molar tooth sign on MRI (HP:0002419)2.06811494
90Congenital glaucoma (HP:0001087)2.04700818
91Congenital primary aphakia (HP:0007707)2.03703227
92Methylmalonic aciduria (HP:0012120)2.02748449
93Hypokinesia (HP:0002375)2.02334223
94Tubular atrophy (HP:0000092)2.01807288
95Macroorchidism (HP:0000053)2.01458395
96Congenital stationary night blindness (HP:0007642)2.01161315
97Orthostatic hypotension (HP:0001278)2.00613790
98Growth hormone excess (HP:0000845)2.00086608
99Hypomagnesemia (HP:0002917)1.95952019
100Chronic bronchitis (HP:0004469)1.95732633
101Type II lissencephaly (HP:0007260)1.95602350
102Anxiety (HP:0000739)1.95349443
103Abnormal albumin level (HP:0012116)1.95272891
104Hypoalbuminemia (HP:0003073)1.95272891
105Vascular calcification (HP:0004934)1.95270750
106Abnormality of abdominal situs (HP:0011620)1.94672480
107Abdominal situs inversus (HP:0003363)1.94672480
108Limb hypertonia (HP:0002509)1.93104290
109Furrowed tongue (HP:0000221)1.91812606
110True hermaphroditism (HP:0010459)1.91504046
111Neoplasm of the adrenal cortex (HP:0100641)1.91295220
1123-Methylglutaconic aciduria (HP:0003535)1.91089476
113Adrenal overactivity (HP:0002717)1.90302828
114Vacuolated lymphocytes (HP:0001922)1.90065561
115Syncope (HP:0001279)1.88927519
116Abnormal sex determination (HP:0012244)1.88798621
117Sex reversal (HP:0012245)1.88798621
118Depression (HP:0000716)1.88664912
119Hypophosphatemia (HP:0002148)1.86656825
120Intestinal atresia (HP:0011100)1.86651766
121Abnormality of the renal medulla (HP:0100957)1.86587366
122Diminished movement (HP:0002374)1.86466967
123Nephrogenic diabetes insipidus (HP:0009806)1.86372388
124Aqueductal stenosis (HP:0002410)1.85997048
125Febrile seizures (HP:0002373)1.85942332
126Renal cortical cysts (HP:0000803)1.84987426
127Abnormal rod and cone electroretinograms (HP:0008323)1.84875697
128Focal motor seizures (HP:0011153)1.84583535
129Abnormal eating behavior (HP:0100738)1.84157605
130Prolonged QT interval (HP:0001657)1.81815309
131Abnormality of chloride homeostasis (HP:0011422)1.80997507
132Exocrine pancreatic insufficiency (HP:0001738)1.80444866
133Failure to thrive in infancy (HP:0001531)1.79977267
134Fetal akinesia sequence (HP:0001989)1.79074148
135Hyperphosphaturia (HP:0003109)1.78052822
136Muscular hypotonia of the trunk (HP:0008936)1.77669732
137Generalized hyperpigmentation (HP:0007440)1.76951909
138Abdominal distention (HP:0003270)1.76532992
139Gout (HP:0001997)1.76120187
140Abnormal autonomic nervous system physiology (HP:0012332)1.73481084
141Neoplasm of the heart (HP:0100544)1.72003545
142Atonic seizures (HP:0010819)1.70467806
143Thoracolumbar scoliosis (HP:0002944)1.69864576
144Hemiparesis (HP:0001269)1.68076943
145Postural tremor (HP:0002174)1.66796640
146Testicular neoplasm (HP:0010788)1.66699925
147Abnormality of glycolipid metabolism (HP:0010969)1.64141136
148Abnormality of liposaccharide metabolism (HP:0010968)1.64141136
149Abnormality of glycosphingolipid metabolism (HP:0004343)1.64141136
150Impaired smooth pursuit (HP:0007772)1.61365684
151Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.61321268
152Abnormal protein N-linked glycosylation (HP:0012347)1.61321268
153Abnormal protein glycosylation (HP:0012346)1.61321268
154Abnormal glycosylation (HP:0012345)1.61321268
155Blue irides (HP:0000635)1.60703008
156Absence seizures (HP:0002121)1.59246924
157Disproportionate short-trunk short stature (HP:0003521)1.58961104
158Hypocalcemia (HP:0002901)1.57227887

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.07733094
2MAPK155.87961120
3WNK34.42473869
4PASK4.03865009
5TAOK33.36563394
6PRKD33.31204276
7FRK3.02271097
8MAP3K22.96845089
9PHKG22.72187886
10PHKG12.72187886
11FGFR22.67375492
12WNK42.65647399
13HIPK22.63994456
14MAP4K22.61964286
15NTRK32.58464077
16PINK12.55946748
17UHMK12.42983231
18PIK3CG2.28981123
19GRK12.21917614
20MST42.19934283
21NTRK12.05997795
22MAP2K62.04519346
23MAP3K11.77648830
24CAMKK21.70098127
25SCYL21.50969622
26MAP3K121.43545879
27FGFR31.38745543
28ERBB31.37634781
29CSNK1G11.37246650
30BMPR1B1.33578692
31FLT31.28439569
32ACVR1B1.26801065
33CDC42BPA1.25987952
34CSNK1G31.25771456
35ERN11.24213644
36CSNK1G21.23874669
37PLK21.22027478
38TRPM71.20777195
39PRKCH1.18965172
40PAK31.15649225
41EPHA31.15462120
42KSR21.09772155
43MAP3K91.07964851
44WNK11.06580682
45IRAK11.03728810
46STK31.02839422
47PDGFRA0.98098858
48PRKD20.96883114
49PTK20.94851164
50STK110.92981024
51IRAK30.92693757
52AKT30.90536964
53CSNK1A1L0.87886965
54MAP3K40.87450867
55DYRK1B0.81873136
56PTK2B0.79195053
57OXSR10.76001780
58DAPK20.75605351
59TAOK10.75237637
60FER0.75006217
61TNK20.73424741
62CAMKK10.73348325
63STK38L0.72798457
64BMPR20.72588413
65TRIM280.72289992
66BRAF0.72030052
67EPHB10.71700304
68MAP2K70.71683102
69RET0.69862773
70CDK50.69617637
71BRSK20.67091240
72PRKCE0.66007330
73CAMK2D0.65181089
74STK390.63857286
75EIF2AK30.62524156
76PTK60.60801340
77GRK50.60178428
78YES10.57938418
79EPHA40.57801135
80DAPK10.57295808
81ARAF0.56885596
82PAK60.56401560
83MET0.54220850
84SGK2230.53513721
85SGK4940.53513721
86MKNK20.52629176
87CASK0.52627656
88MINK10.52485364
89PRKG10.52408276
90CAMK2B0.52070482
91MARK10.49332570
92MAP2K20.49068772
93LIMK10.48890276
94PRKCG0.48570086
95BRD40.48382857
96PRKAA20.46054067
97CAMK1G0.45690354
98DYRK20.45646226
99NUAK10.44513078
100PRKAA10.43450501
101MARK20.43350794
102NEK60.43168085
103ZAK0.43145758
104BRSK10.42901070
105DYRK1A0.42656425
106IRAK20.42592693
107SGK20.42541054
108CAMK10.42262951
109PNCK0.41625902
110CSNK1D0.39477200
111PRKCZ0.38660682
112PRKCI0.37803794
113JAK20.37219167
114CSNK1A10.36858162
115MAP2K40.35230485
116RPS6KA20.35037638
117SGK10.35002413
118CAMK2A0.34919741
119BCKDK0.34494668
120MAP2K10.33097577
121TRIB30.32326633
122PRKACA0.31905561
123STK240.31781515
124PRKG20.30919641
125RIPK40.30730136
126PRKACG0.30564187
127MUSK0.30464802
128MAPK130.30083874
129MAPK100.29349446
130PRKACB0.29300399
131RPS6KB10.28952901
132RPS6KA30.28629751
133SGK30.27505797
134CSNK1E0.27460695
135PRKD10.26878353
136STK160.26837333
137BCR0.26421498
138ADRBK10.25707007
139TESK10.25457058
140PRKDC0.24351760
141ADRBK20.24256727
142PRKCA0.23999043
143ITK0.21266064
144TNIK0.19961058
145PDPK10.19865208
146NLK0.19486853
147NTRK20.19206113

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.87660815
2Protein export_Homo sapiens_hsa030604.40676171
3Insulin secretion_Homo sapiens_hsa049113.70072389
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.58268112
5Type I diabetes mellitus_Homo sapiens_hsa049402.45729989
6Type II diabetes mellitus_Homo sapiens_hsa049302.40905476
7Sulfur metabolism_Homo sapiens_hsa009202.35551072
8Vibrio cholerae infection_Homo sapiens_hsa051102.18349067
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.14632341
10Vitamin B6 metabolism_Homo sapiens_hsa007502.08581423
11Cocaine addiction_Homo sapiens_hsa050301.97630331
12Amphetamine addiction_Homo sapiens_hsa050311.92898854
13Synaptic vesicle cycle_Homo sapiens_hsa047211.80168985
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.69707907
15Phototransduction_Homo sapiens_hsa047441.69263758
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.69071998
17Carbohydrate digestion and absorption_Homo sapiens_hsa049731.64632918
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.64592629
19Taste transduction_Homo sapiens_hsa047421.60395148
20Circadian entrainment_Homo sapiens_hsa047131.54778322
21GABAergic synapse_Homo sapiens_hsa047271.51840084
22Long-term potentiation_Homo sapiens_hsa047201.48993420
23Dopaminergic synapse_Homo sapiens_hsa047281.47704162
24Ether lipid metabolism_Homo sapiens_hsa005651.45425373
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43563471
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42313025
27N-Glycan biosynthesis_Homo sapiens_hsa005101.38784119
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.38502640
29Collecting duct acid secretion_Homo sapiens_hsa049661.27482433
30Circadian rhythm_Homo sapiens_hsa047101.26783786
31Pancreatic secretion_Homo sapiens_hsa049721.26362651
32Lysosome_Homo sapiens_hsa041421.24006438
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.23883324
34Morphine addiction_Homo sapiens_hsa050321.22858414
35Cholinergic synapse_Homo sapiens_hsa047251.22470707
36Serotonergic synapse_Homo sapiens_hsa047261.21319399
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.19386440
38Glucagon signaling pathway_Homo sapiens_hsa049221.19175750
39Parkinsons disease_Homo sapiens_hsa050121.18322205
40Peroxisome_Homo sapiens_hsa041461.14220869
41Thyroid hormone synthesis_Homo sapiens_hsa049181.13654514
42Regulation of autophagy_Homo sapiens_hsa041401.09215207
43Renin secretion_Homo sapiens_hsa049241.08010156
44Cardiac muscle contraction_Homo sapiens_hsa042601.07662166
45SNARE interactions in vesicular transport_Homo sapiens_hsa041301.06804495
46Arginine biosynthesis_Homo sapiens_hsa002201.02423130
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02245405
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02042428
49Glutamatergic synapse_Homo sapiens_hsa047241.01821958
50Fatty acid elongation_Homo sapiens_hsa000620.98377871
51Estrogen signaling pathway_Homo sapiens_hsa049150.97080695
52Prion diseases_Homo sapiens_hsa050200.93318995
53Other glycan degradation_Homo sapiens_hsa005110.92590848
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90058364
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.86462638
56Mineral absorption_Homo sapiens_hsa049780.86086491
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84434333
58Propanoate metabolism_Homo sapiens_hsa006400.84164861
59Olfactory transduction_Homo sapiens_hsa047400.82937357
60Nicotine addiction_Homo sapiens_hsa050330.81567287
61beta-Alanine metabolism_Homo sapiens_hsa004100.80366576
62Gastric acid secretion_Homo sapiens_hsa049710.79771578
63Long-term depression_Homo sapiens_hsa047300.79362421
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78917165
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78061929
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76082832
67Selenocompound metabolism_Homo sapiens_hsa004500.75632786
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74370197
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74092151
70cAMP signaling pathway_Homo sapiens_hsa040240.72375412
71Salivary secretion_Homo sapiens_hsa049700.72024811
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71101793
73ABC transporters_Homo sapiens_hsa020100.70556308
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.70041005
75Prolactin signaling pathway_Homo sapiens_hsa049170.67619945
76Insulin resistance_Homo sapiens_hsa049310.66608230
77Nitrogen metabolism_Homo sapiens_hsa009100.65290657
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63992411
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63325805
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63119655
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61895428
82Alcoholism_Homo sapiens_hsa050340.61199884
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61121959
84GnRH signaling pathway_Homo sapiens_hsa049120.61081487
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58501764
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57506017
87Retinol metabolism_Homo sapiens_hsa008300.57288574
88Oxytocin signaling pathway_Homo sapiens_hsa049210.57278706
89Gap junction_Homo sapiens_hsa045400.56975304
90Huntingtons disease_Homo sapiens_hsa050160.56125683
91Dorso-ventral axis formation_Homo sapiens_hsa043200.56114327
92Fatty acid metabolism_Homo sapiens_hsa012120.55198924
93Melanogenesis_Homo sapiens_hsa049160.54793179
94Metabolic pathways_Homo sapiens_hsa011000.54690358
95Sphingolipid metabolism_Homo sapiens_hsa006000.53670210
96Insulin signaling pathway_Homo sapiens_hsa049100.53147950
97Calcium signaling pathway_Homo sapiens_hsa040200.53130996
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52021598
99Inositol phosphate metabolism_Homo sapiens_hsa005620.48198982
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47476616
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46953761
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.45102464
103Folate biosynthesis_Homo sapiens_hsa007900.44952157
104Galactose metabolism_Homo sapiens_hsa000520.44242637
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43951334
106Arachidonic acid metabolism_Homo sapiens_hsa005900.42490152
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41641228
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39977417
109Linoleic acid metabolism_Homo sapiens_hsa005910.39784464
110Renin-angiotensin system_Homo sapiens_hsa046140.39517863
111Alzheimers disease_Homo sapiens_hsa050100.39130855
112mTOR signaling pathway_Homo sapiens_hsa041500.38414737
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38247928
114Caffeine metabolism_Homo sapiens_hsa002320.37895479
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34763588
116Bile secretion_Homo sapiens_hsa049760.34413094
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30323164
118Ovarian steroidogenesis_Homo sapiens_hsa049130.30302143
119Butanoate metabolism_Homo sapiens_hsa006500.29551701
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29446206
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.28924653
122Glioma_Homo sapiens_hsa052140.27806240
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.26336568
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26314355
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26183817
126Oxidative phosphorylation_Homo sapiens_hsa001900.24682073
127Protein digestion and absorption_Homo sapiens_hsa049740.24138967
128ErbB signaling pathway_Homo sapiens_hsa040120.21132898
129Starch and sucrose metabolism_Homo sapiens_hsa005000.20849066
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20044927
131AMPK signaling pathway_Homo sapiens_hsa041520.18814067
132Phagosome_Homo sapiens_hsa041450.18738613
133Thyroid cancer_Homo sapiens_hsa052160.17728768
134Tryptophan metabolism_Homo sapiens_hsa003800.17066817

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