PCSK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. The protease is expressed only in the testis, placenta, and ovary. It plays a critical role in fertilization, fetoplacental growth, and embryonic development and processes multiple prohormones including pro-pituitary adenylate cyclase-activating protein and pro-insulin-like growth factor II. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome condensation (GO:0030261)9.25993474
2response to pheromone (GO:0019236)9.08928930
3DNA packaging (GO:0006323)9.00432782
4single strand break repair (GO:0000012)8.26062296
5spermatid nucleus differentiation (GO:0007289)8.22647995
6microtubule depolymerization (GO:0007019)7.45838055
7sexual reproduction (GO:0019953)7.37193929
8negative regulation of inclusion body assembly (GO:0090084)6.72313643
9sperm motility (GO:0030317)6.61457461
10phosphatidylethanolamine biosynthetic process (GO:0006646)6.51106273
11protein polyglutamylation (GO:0018095)6.47591519
12microtubule severing (GO:0051013)6.24206938
13fusion of sperm to egg plasma membrane (GO:0007342)6.20520700
14rRNA methylation (GO:0031167)6.08302982
15phosphatidylethanolamine metabolic process (GO:0046337)5.94312155
16microtubule polymerization or depolymerization (GO:0031109)5.87354304
17* sperm-egg recognition (GO:0035036)5.78539133
18L-phenylalanine catabolic process (GO:0006559)5.77434330
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.77434330
20cilium or flagellum-dependent cell motility (GO:0001539)5.73123361
21spermatogenesis (GO:0007283)5.68983220
22male gamete generation (GO:0048232)5.66922282
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.56979364
24L-phenylalanine metabolic process (GO:0006558)5.56979364
25cell wall macromolecule catabolic process (GO:0016998)5.53215275
26cell wall macromolecule metabolic process (GO:0044036)5.53215275
27protein targeting to Golgi (GO:0000042)5.32575767
28regulation of Rab GTPase activity (GO:0032313)5.30247264
29positive regulation of Rab GTPase activity (GO:0032851)5.30247264
30acrosome assembly (GO:0001675)5.20526585
31gamete generation (GO:0007276)5.17078158
32multicellular organism reproduction (GO:0032504)5.15691805
33* cell-cell recognition (GO:0009988)5.14252364
34axonemal dynein complex assembly (GO:0070286)5.13727192
35* binding of sperm to zona pellucida (GO:0007339)5.10404197
36chromatin silencing (GO:0006342)5.07464103
37establishment of protein localization to Golgi (GO:0072600)5.06189126
38rRNA modification (GO:0000154)5.05489784
39retrograde transport, vesicle recycling within Golgi (GO:0000301)5.00092461
40aromatic amino acid family catabolic process (GO:0009074)4.97204562
41regulation of inclusion body assembly (GO:0090083)4.90358326
42epithelial cilium movement (GO:0003351)4.89066194
43triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.76627609
44ketone body metabolic process (GO:1902224)4.72400182
45spermatid development (GO:0007286)4.66623959
46* calcium ion-dependent exocytosis (GO:0017156)4.63648630
47urea cycle (GO:0000050)4.62049387
48urea metabolic process (GO:0019627)4.62049387
49* acrosome reaction (GO:0007340)4.60778255
50regulation of microtubule-based movement (GO:0060632)4.54674948
51plasma membrane fusion (GO:0045026)4.54520587
52centriole replication (GO:0007099)4.53817291
53regulation of transcription involved in cell fate commitment (GO:0060850)4.52993458
54germ cell development (GO:0007281)4.51988532
55alpha-linolenic acid metabolic process (GO:0036109)4.50663566
56motile cilium assembly (GO:0044458)4.49501687
57reproduction (GO:0000003)4.42925096
58centriole assembly (GO:0098534)4.37682873
59RNA destabilization (GO:0050779)4.35189660
60fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.33181600
61cilium movement (GO:0003341)4.29852976
62regulation of cilium movement (GO:0003352)4.29693421
63tryptophan catabolic process (GO:0006569)4.28917257
64indole-containing compound catabolic process (GO:0042436)4.28917257
65indolalkylamine catabolic process (GO:0046218)4.28917257
66organic cation transport (GO:0015695)4.28005073
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.27395339
68nitrogen cycle metabolic process (GO:0071941)4.24411324
69bile acid biosynthetic process (GO:0006699)4.22705608
70protein-DNA complex disassembly (GO:0032986)4.22558661
71nucleosome disassembly (GO:0006337)4.22558661
72kynurenine metabolic process (GO:0070189)4.19061787
73high-density lipoprotein particle remodeling (GO:0034375)4.18905497
74multicellular organismal reproductive process (GO:0048609)4.16178383
75response to acidic pH (GO:0010447)4.12008534
76protein localization to Golgi apparatus (GO:0034067)4.09393543
77* cellular process involved in reproduction in multicellular organism (GO:0022412)4.07984545
78negative regulation of Rho protein signal transduction (GO:0035024)4.05291557
79sulfur amino acid catabolic process (GO:0000098)4.03394823
80nucleus organization (GO:0006997)4.02455541
81tryptophan metabolic process (GO:0006568)4.01799437
82glyoxylate metabolic process (GO:0046487)3.97774307
83lysine metabolic process (GO:0006553)3.95594957
84lysine catabolic process (GO:0006554)3.95594957
85regulation of somitogenesis (GO:0014807)3.91811796
86cerebral cortex neuron differentiation (GO:0021895)3.91195207
87epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.90446694
88cranial nerve morphogenesis (GO:0021602)3.89373973
89regulation of triglyceride catabolic process (GO:0010896)3.84234961
90polyamine biosynthetic process (GO:0006596)3.83595887
91amino-acid betaine metabolic process (GO:0006577)3.80649264
92cysteine metabolic process (GO:0006534)3.79164563
93fertilization (GO:0009566)3.76825428
94histone H3-K9 demethylation (GO:0033169)3.75648963
95negative regulation of sterol transport (GO:0032372)3.70815163
96negative regulation of cholesterol transport (GO:0032375)3.70815163
97bile acid metabolic process (GO:0008206)3.67843942
98cellular response to pH (GO:0071467)3.64162431
99negative regulation of fibrinolysis (GO:0051918)3.63243036
100male meiosis (GO:0007140)3.61220687
101cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.60592147
102regulation of cholesterol esterification (GO:0010872)3.60079424
103negative regulation of gene expression, epigenetic (GO:0045814)3.59448858
104regulation of interleukin-13 production (GO:0032656)3.57456928
105aromatic amino acid family metabolic process (GO:0009072)3.53456840
106protein carboxylation (GO:0018214)3.52165495
107peptidyl-glutamic acid carboxylation (GO:0017187)3.52165495
108protein-lipid complex remodeling (GO:0034368)3.52119660
109macromolecular complex remodeling (GO:0034367)3.52119660
110plasma lipoprotein particle remodeling (GO:0034369)3.52119660
111complement activation, alternative pathway (GO:0006957)3.51840039
112seminiferous tubule development (GO:0072520)3.51115987
113reverse cholesterol transport (GO:0043691)3.50804404
114regulation of fibrinolysis (GO:0051917)3.48235949
115alpha-amino acid catabolic process (GO:1901606)3.47199359
116regulation of protein activation cascade (GO:2000257)3.44394421
117acylglycerol homeostasis (GO:0055090)3.43931729
118triglyceride homeostasis (GO:0070328)3.43931729
119imidazole-containing compound metabolic process (GO:0052803)3.43312448
120single fertilization (GO:0007338)3.38358002
121DNA deamination (GO:0045006)3.37920242
122regulation of centriole replication (GO:0046599)3.37244532
123* sperm capacitation (GO:0048240)3.36535199
124synaptonemal complex organization (GO:0070193)3.36018819
125regulation of ARF GTPase activity (GO:0032312)3.34150979
126serine family amino acid catabolic process (GO:0009071)3.33751988
127phospholipid efflux (GO:0033700)3.32998257
128glycine metabolic process (GO:0006544)3.30524512
129coenzyme catabolic process (GO:0009109)3.30240036
130synaptonemal complex assembly (GO:0007130)3.29814019
131tyrosine metabolic process (GO:0006570)3.28945011
132tooth mineralization (GO:0034505)3.26650155
133membrane protein intracellular domain proteolysis (GO:0031293)3.26225438
134homocysteine metabolic process (GO:0050667)3.23815608
135piRNA metabolic process (GO:0034587)3.23590088
136aspartate family amino acid catabolic process (GO:0009068)3.22325945
137carnitine metabolic process (GO:0009437)3.20526773
138regulation of complement activation (GO:0030449)3.19943069
139drug catabolic process (GO:0042737)3.19910276
140plasma lipoprotein particle clearance (GO:0034381)3.19715541
141serine family amino acid biosynthetic process (GO:0009070)3.16611640
142cellular amino acid catabolic process (GO:0009063)3.14990704
143regulation of T-helper 2 cell differentiation (GO:0045628)3.14241973
144musculoskeletal movement (GO:0050881)3.13022559
145multicellular organismal movement (GO:0050879)3.13022559
146cell differentiation involved in metanephros development (GO:0072202)3.11887213
147ethanol oxidation (GO:0006069)3.11415261
148peptidyl-glutamic acid modification (GO:0018200)3.11391144
149blood coagulation, intrinsic pathway (GO:0007597)3.11227728
150positive regulation of triglyceride lipase activity (GO:0061365)3.10224555
151positive regulation of lipoprotein lipase activity (GO:0051006)3.10224555
152glycerol ether metabolic process (GO:0006662)3.07584114
153serine family amino acid metabolic process (GO:0009069)3.06110358
154cellular ketone body metabolic process (GO:0046950)3.05206185
155histone H4 deacetylation (GO:0070933)3.04898063
156bile acid and bile salt transport (GO:0015721)3.04430461
157pyrimidine nucleoside catabolic process (GO:0046135)3.03648794
158cofactor catabolic process (GO:0051187)3.03493408
159multicellular organismal development (GO:0007275)3.03146864
160mitotic G1 DNA damage checkpoint (GO:0031571)3.02179524
161indolalkylamine metabolic process (GO:0006586)3.01487233
162NAD biosynthetic process (GO:0009435)3.00280359
163homeostasis of number of cells within a tissue (GO:0048873)2.99709113
164drug transmembrane transport (GO:0006855)2.98491719
165peptidyl-threonine dephosphorylation (GO:0035970)2.97032582
166negative regulation of histone methylation (GO:0031061)2.95960094
167receptor recycling (GO:0001881)2.94530553
168cell-cell junction maintenance (GO:0045217)2.94401350
169axoneme assembly (GO:0035082)2.93269958
170intestinal cholesterol absorption (GO:0030299)2.92313803
171drug metabolic process (GO:0017144)2.91345104
172protein depolymerization (GO:0051261)2.90482393
173DNA conformation change (GO:0071103)2.89951100
174ether metabolic process (GO:0018904)2.82767506
175mesenchymal cell differentiation involved in renal system development (GO:2001012)2.82338369
176mesenchymal cell differentiation involved in kidney development (GO:0072161)2.82338369

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.16448631
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.30276125
3* RXR_22158963_ChIP-Seq_LIVER_Mouse5.09731611
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.98846676
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.56271396
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.45045428
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.74636967
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.72736598
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.48506204
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.14410988
11* FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.08651877
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.61307328
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.58196874
14EZH2_22144423_ChIP-Seq_EOC_Human2.46349843
15CTCF_27219007_Chip-Seq_Bcells_Human2.45429989
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.44297697
17SMC4_20622854_ChIP-Seq_HELA_Human2.29853109
18DROSHA_22980978_ChIP-Seq_HELA_Human2.25217366
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.05798198
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.05504102
21ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.05206252
22SCL_19346495_ChIP-Seq_HPC-7_Human2.04413304
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.96601463
24* ERA_21632823_ChIP-Seq_H3396_Human1.96580237
25VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.84423247
26TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83463340
27POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.83463340
28CTCF_20526341_ChIP-Seq_ESCs_Human1.82245416
29TP63_22573176_ChIP-Seq_HFKS_Human1.79554433
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.78231548
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77002410
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72480460
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.72348587
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.68660399
35WDR5_24793694_ChIP-Seq_LNCAP_Human1.64152890
36SA1_27219007_Chip-Seq_ERYTHROID_Human1.59968022
37TDRD3_21172665_ChIP-Seq_MCF-7_Human1.53896545
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.52430397
39TAF2_19829295_ChIP-Seq_ESCs_Human1.51520965
40SA1_27219007_Chip-Seq_Bcells_Human1.51511621
41P300_27268052_Chip-Seq_Bcells_Human1.50424809
42NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.50128988
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46296011
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.45929070
45OCT4_20526341_ChIP-Seq_ESCs_Human1.45848509
46* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45538551
47EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.45479973
48EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44445550
49P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.43101664
50RXRA_24833708_ChIP-Seq_LIVER_Mouse1.41481800
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41037061
52MYC_19829295_ChIP-Seq_ESCs_Human1.36191749
53MYC_18555785_ChIP-Seq_MESCs_Mouse1.35558378
54GATA3_21867929_ChIP-Seq_CD8_Mouse1.31927911
55RUNX1_27514584_Chip-Seq_MCF-7_Human1.31517162
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30919035
57CBP_20019798_ChIP-Seq_JUKART_Human1.30868627
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30868627
59RARA_24833708_ChIP-Seq_LIVER_Mouse1.30714253
60LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30076949
61OCT4_19829295_ChIP-Seq_ESCs_Human1.29153078
62* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.27568967
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26886361
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26631869
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.25996728
66* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25644864
67TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.24705792
68CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.24619492
69RUNX1_26923725_Chip-Seq_HPCs_Mouse1.24547914
70SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24311180
71SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.22193205
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21028041
73* TET1_21451524_ChIP-Seq_MESCs_Mouse1.20825119
74* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.19724969
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18952232
76KAP1_22055183_ChIP-Seq_ESCs_Mouse1.17269594
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.15450966
78KLF4_19829295_ChIP-Seq_ESCs_Human1.14460638
79KDM2B_26808549_Chip-Seq_K562_Human1.13885849
80FOXP1_21924763_ChIP-Seq_HESCs_Human1.13169135
81CTCF_21964334_Chip-Seq_Bcells_Human1.12969842
82ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12836340
83P53_21459846_ChIP-Seq_SAOS-2_Human1.12521920
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10870106
85TET1_21490601_ChIP-Seq_MESCs_Mouse1.10691067
86NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10563789
87SOX11_22085726_ChIP-Seq_ESNs_Mouse1.10530167
88FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09271172
89* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.09118687
90SPI1_20517297_ChIP-Seq_HL60_Human1.08682594
91SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08155709
92PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.08003383
93PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07682305
94BCL6_27268052_Chip-Seq_Bcells_Human1.07496163
95IRF8_22096565_ChIP-ChIP_GC-B_Human1.06915504
96PHF8_20622854_ChIP-Seq_HELA_Human1.06806151
97PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06483534
98CEBPB_22108803_ChIP-Seq_LS180_Human1.06238698
99GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06092732
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05776490
101STAT1_17558387_ChIP-Seq_HELA_Human1.05746055
102KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05539468
103KLF5_25053715_ChIP-Seq_YYC3_Human1.05406959
104TP53_22127205_ChIP-Seq_IMR90_Human1.04339790
105TP63_19390658_ChIP-ChIP_HaCaT_Human1.04236331
106HTT_18923047_ChIP-ChIP_STHdh_Human1.03504613
107RARB_24833708_ChIP-Seq_LIVER_Mouse1.03466483
108BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03255156
109YY1_22570637_ChIP-Seq_MALME-3M_Human1.03156960
110IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02824765
111KDM2B_26808549_Chip-Seq_DND41_Human1.02552314
112CTCF_26484167_Chip-Seq_Bcells_Mouse1.02059956
113RAD21_21589869_ChIP-Seq_MESCs_Mouse1.01658793
114P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00627275
115AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00422616
116SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99481824
117ERG_20517297_ChIP-Seq_VCAP_Human0.99068114
118KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.98838588
119ARNT_22903824_ChIP-Seq_MCF-7_Human0.98149574
120SMAD3_21741376_ChIP-Seq_ESCs_Human0.98020105
121BCOR_27268052_Chip-Seq_Bcells_Human0.97872534
122HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97864862
123CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97346403
124CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97312205
125ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96721042
126CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96605513
127PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96479891
128SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95138850
129CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95095334
130MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.94953729
131GATA3_21878914_ChIP-Seq_MCF-7_Human0.94633265
132E2F1_17053090_ChIP-ChIP_MCF-7_Human0.94470210
133ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93285161
134FOXP3_21729870_ChIP-Seq_TREG_Human0.93081586
135RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92913596
136SOX2_21211035_ChIP-Seq_LN229_Human0.92820524
137E2F1_20622854_ChIP-Seq_HELA_Human0.92641542
138TP53_23651856_ChIP-Seq_MEFs_Mouse0.92496253
139RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92227243
140UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92170233
141CSB_26484114_Chip-Seq_FIBROBLAST_Human0.91797849
142JARID2_20075857_ChIP-Seq_MESCs_Mouse0.91756222
143* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90668405
144SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90524815
145SPI1_26923725_Chip-Seq_HPCs_Mouse0.89777524
146FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89452903
147SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88773975
148NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.88255623
149PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88148908
150SRF_21415370_ChIP-Seq_HL-1_Mouse0.87968086
151GATA3_21867929_ChIP-Seq_TH1_Mouse0.87856849
152MYC_22102868_ChIP-Seq_BL_Human0.87777889
153DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87658443
154EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.85878913
155SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.85875370
156ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85802578
157EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85361748
158P68_20966046_ChIP-Seq_HELA_Human0.85156539
159CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84663492
160NANOG_20526341_ChIP-Seq_ESCs_Human0.84577532
161XRN2_22483619_ChIP-Seq_HELA_Human0.83948670
162LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.83922872
163GATA1_22025678_ChIP-Seq_K562_Human0.83365139
164STAT1_20625510_ChIP-Seq_HELA_Human0.82644711
165FLI1_21867929_ChIP-Seq_CD8_Mouse0.81853963
166SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81381274
167CTCF_21964334_ChIP-Seq_BJAB-B_Human0.81190428
168STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80885667
169GABP_19822575_ChIP-Seq_HepG2_Human0.80484413
170RAC3_21632823_ChIP-Seq_H3396_Human0.80331697
171ESET_19884257_ChIP-Seq_ESCs_Mouse0.79529988
172LXR_22292898_ChIP-Seq_THP-1_Human0.79307772

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.75412917
2* MP0005410_abnormal_fertilization6.14082272
3MP0005360_urolithiasis6.04063374
4MP0005365_abnormal_bile_salt5.36106095
5MP0005377_hearing/vestibular/ear_phenot5.10847888
6MP0003878_abnormal_ear_physiology5.10847888
7MP0005085_abnormal_gallbladder_physiolo5.02114491
8MP0008875_abnormal_xenobiotic_pharmacok4.63150650
9MP0001348_abnormal_lacrimal_gland3.94233126
10MP0000678_abnormal_parathyroid_gland3.51915355
11MP0003806_abnormal_nucleotide_metabolis3.51455875
12MP0010329_abnormal_lipoprotein_level3.16310243
13MP0003252_abnormal_bile_duct3.13944316
14MP0002249_abnormal_larynx_morphology2.73894415
15MP0005083_abnormal_biliary_tract2.55413846
16MP0009840_abnormal_foam_cell2.38885054
17* MP0003698_abnormal_male_reproductive2.33660081
18* MP0001929_abnormal_gametogenesis2.23667573
19MP0001764_abnormal_homeostasis2.14725681
20MP0005332_abnormal_amino_acid2.07397999
21MP0001666_abnormal_nutrient_absorption2.06052505
22MP0000609_abnormal_liver_physiology1.99525849
23MP0002234_abnormal_pharynx_morphology1.96981319
24MP0003195_calcinosis1.91714405
25MP0003191_abnormal_cellular_cholesterol1.87451543
26MP0005670_abnormal_white_adipose1.83362559
27MP0004859_abnormal_synaptic_plasticity1.78149968
28MP0002118_abnormal_lipid_homeostasis1.76061864
29MP0005319_abnormal_enzyme/_coenzyme1.71050775
30MP0004019_abnormal_vitamin_homeostasis1.66319292
31MP0002822_catalepsy1.66130617
32MP0003868_abnormal_feces_composition1.62784586
33MP0003656_abnormal_erythrocyte_physiolo1.62696875
34MP0002282_abnormal_trachea_morphology1.61321044
35MP0003646_muscle_fatigue1.60503349
36MP0003718_maternal_effect1.56893258
37MP0006036_abnormal_mitochondrial_physio1.51084634
38MP0009053_abnormal_anal_canal1.49994544
39MP0005636_abnormal_mineral_homeostasis1.44923776
40MP0000534_abnormal_ureter_morphology1.41810910
41MP0001485_abnormal_pinna_reflex1.39465683
42MP0002210_abnormal_sex_determination1.39427144
43MP0009697_abnormal_copulation1.39374324
44MP0005584_abnormal_enzyme/coenzyme_acti1.38060210
45MP0006292_abnormal_olfactory_placode1.35568872
46MP0000566_synostosis1.34756036
47MP0005647_abnormal_sex_gland1.33212656
48* MP0002161_abnormal_fertility/fecundity1.32459428
49MP0003011_delayed_dark_adaptation1.31756597
50MP0009643_abnormal_urine_homeostasis1.30844982
51MP0000049_abnormal_middle_ear1.28664767
52MP0001145_abnormal_male_reproductive1.24235254
53MP0002735_abnormal_chemical_nociception1.24206379
54MP0001486_abnormal_startle_reflex1.20864769
55MP0002653_abnormal_ependyma_morphology1.20331072
56MP0000681_abnormal_thyroid_gland1.19946074
57MP0005220_abnormal_exocrine_pancreas1.17904932
58MP0000598_abnormal_liver_morphology1.15844529
59MP0000026_abnormal_inner_ear1.13969900
60MP0005248_abnormal_Harderian_gland1.13230951
61MP0000653_abnormal_sex_gland1.13212582
62MP0000955_abnormal_spinal_cord1.12273534
63MP0005379_endocrine/exocrine_gland_phen1.11064154
64MP0001968_abnormal_touch/_nociception1.11004677
65MP0001963_abnormal_hearing_physiology1.10518457
66MP0002138_abnormal_hepatobiliary_system1.10406671
67MP0005666_abnormal_adipose_tissue1.09196938
68MP0003879_abnormal_hair_cell1.09164646
69MP0008995_early_reproductive_senescence1.03744433
70MP0005397_hematopoietic_system_phenotyp1.03277501
71MP0001545_abnormal_hematopoietic_system1.03277501
72MP0008469_abnormal_protein_level1.02938133
73MP0003186_abnormal_redox_activity1.01614297
74MP0005310_abnormal_salivary_gland0.98350740
75MP0002078_abnormal_glucose_homeostasis0.98309093
76MP0004742_abnormal_vestibular_system0.98284842
77MP0005464_abnormal_platelet_physiology0.97002327
78MP0002127_abnormal_cardiovascular_syste0.96868318
79MP0002396_abnormal_hematopoietic_system0.95791813
80MP0009642_abnormal_blood_homeostasis0.95708633
81MP0002928_abnormal_bile_duct0.95623319
82MP0002229_neurodegeneration0.93743502
83MP0003136_yellow_coat_color0.93716001
84MP0005375_adipose_tissue_phenotype0.93111610
85MP0008877_abnormal_DNA_methylation0.92549781
86MP0002132_abnormal_respiratory_system0.92485125
87MP0001944_abnormal_pancreas_morphology0.92017990
88MP0005499_abnormal_olfactory_system0.90715171
89MP0005394_taste/olfaction_phenotype0.90715171
90MP0004510_myositis0.90130465
91MP0005084_abnormal_gallbladder_morpholo0.88530029
92MP0009763_increased_sensitivity_to0.88443221
93MP0008789_abnormal_olfactory_epithelium0.87494074
94MP0002557_abnormal_social/conspecific_i0.86965907
95MP0001765_abnormal_ion_homeostasis0.86459197
96MP0000003_abnormal_adipose_tissue0.83733386
97MP0002693_abnormal_pancreas_physiology0.83469144
98MP0003942_abnormal_urinary_system0.83361576
99MP0005266_abnormal_metabolism0.81531776
100MP0005395_other_phenotype0.80843197
101MP0005376_homeostasis/metabolism_phenot0.79268534
102MP0006035_abnormal_mitochondrial_morpho0.78970909
103MP0005334_abnormal_fat_pad0.78864421
104MP0002971_abnormal_brown_adipose0.78469392
105MP0009115_abnormal_fat_cell0.78469335
106MP0002733_abnormal_thermal_nociception0.76262318
107MP0004233_abnormal_muscle_weight0.75861752
108MP0008058_abnormal_DNA_repair0.73478837
109MP0008569_lethality_at_weaning0.70113679
110MP0000685_abnormal_immune_system0.69080855
111MP0009764_decreased_sensitivity_to0.68086921
112MP0002067_abnormal_sensory_capabilities0.67674749
113MP0004264_abnormal_extraembryonic_tissu0.67549124
114MP0004147_increased_porphyrin_level0.66576465
115MP0000613_abnormal_salivary_gland0.66027705
116MP0003724_increased_susceptibility_to0.65880645
117MP0002572_abnormal_emotion/affect_behav0.64318950
118MP0005075_abnormal_melanosome_morpholog0.63904399
119MP0001970_abnormal_pain_threshold0.63786268
120MP0009765_abnormal_xenobiotic_induced0.62790363
121MP0003953_abnormal_hormone_level0.62222521
122MP0005535_abnormal_body_temperature0.60323109
123MP0003119_abnormal_digestive_system0.60023462
124MP0005451_abnormal_body_composition0.59998704
125MP0002970_abnormal_white_adipose0.59638689
126MP0005551_abnormal_eye_electrophysiolog0.59157362
127MP0003861_abnormal_nervous_system0.58893203
128MP0004043_abnormal_pH_regulation0.58314753
129MP0005448_abnormal_energy_balance0.57939256
130MP0003638_abnormal_response/metabolism_0.57916294
131MP0002734_abnormal_mechanical_nocicepti0.57401063
132MP0002882_abnormal_neuron_morphology0.57110013
133MP0003329_amyloid_beta_deposits0.57020673
134MP0000778_abnormal_nervous_system0.56990728
135MP0001984_abnormal_olfaction0.56722144
136MP0005646_abnormal_pituitary_gland0.56000941
137MP0008872_abnormal_physiological_respon0.55632602
138MP0003763_abnormal_thymus_physiology0.55118285
139MP0001905_abnormal_dopamine_level0.54619078
140MP0003122_maternal_imprinting0.53688713
141MP0008961_abnormal_basal_metabolism0.53355924
142MP0000604_amyloidosis0.53057497
143MP0005423_abnormal_somatic_nervous0.52741938
144MP0009278_abnormal_bone_marrow0.52638642
145MP0001853_heart_inflammation0.52631323
146MP0001986_abnormal_taste_sensitivity0.52594639
147MP0004085_abnormal_heartbeat0.51956163
148MP0003635_abnormal_synaptic_transmissio0.51440242
149MP0005623_abnormal_meninges_morphology0.50424220
150MP0003436_decreased_susceptibility_to0.49026889
151MP0002932_abnormal_joint_morphology0.48871110
152MP0003943_abnormal_hepatobiliary_system0.48633821
153MP0008057_abnormal_DNA_replication0.48540268
154MP0003183_abnormal_peptide_metabolism0.48121517
155MP0003172_abnormal_lysosome_physiology0.47587187
156MP0000358_abnormal_cell_content/0.47338648
157MP0003786_premature_aging0.46804134
158MP0008873_increased_physiological_sensi0.46514827
159MP0003115_abnormal_respiratory_system0.45985073
160MP0004808_abnormal_hematopoietic_stem0.45638925
161MP0001324_abnormal_eye_pigmentation0.45246298
162MP0001440_abnormal_grooming_behavior0.45097966
163MP0001270_distended_abdomen0.44891032
164MP0001661_extended_life_span0.43589214
165MP0001845_abnormal_inflammatory_respons0.42619760
166MP0002752_abnormal_somatic_nervous0.42332994
167MP0000639_abnormal_adrenal_gland0.42216812
168MP0005025_abnormal_response_to0.42185788
169MP0002272_abnormal_nervous_system0.42112655
170MP0000467_abnormal_esophagus_morphology0.41401193
171MP0001849_ear_inflammation0.40411315
172MP0009745_abnormal_behavioral_response0.39907935
173MP0004811_abnormal_neuron_physiology0.39765000
174MP0003137_abnormal_impulse_conducting0.39561565
175MP0000470_abnormal_stomach_morphology0.39386667
176MP0000516_abnormal_urinary_system0.39369034
177MP0005367_renal/urinary_system_phenotyp0.39369034
178MP0003959_abnormal_lean_body0.38243992

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.40943367
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.13288142
3Dynein arm defect of respiratory motile cilia (HP:0012255)6.20464253
4Absent/shortened dynein arms (HP:0200106)6.20464253
5Abnormality of aromatic amino acid family metabolism (HP:0004338)6.01743190
6Abnormal respiratory motile cilium physiology (HP:0012261)4.97422941
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.85580348
8Intrahepatic cholestasis (HP:0001406)4.78614367
9Nasal polyposis (HP:0100582)4.64076772
10Hypobetalipoproteinemia (HP:0003563)4.54622361
11Abnormal respiratory epithelium morphology (HP:0012253)4.52736968
12Abnormal respiratory motile cilium morphology (HP:0005938)4.52736968
13Bell-shaped thorax (HP:0001591)4.48218321
14Bony spicule pigmentary retinopathy (HP:0007737)4.36190199
15Deep venous thrombosis (HP:0002625)4.34548200
16Prolonged partial thromboplastin time (HP:0003645)4.31748770
17Xanthomatosis (HP:0000991)4.27071664
18Asymmetric septal hypertrophy (HP:0001670)4.16067596
19Abnormal ciliary motility (HP:0012262)4.11135587
20Chronic bronchitis (HP:0004469)4.06410080
21Rhinitis (HP:0012384)4.06021766
22Abnormality of the nasal mucosa (HP:0000433)4.03910726
23Hyperkalemia (HP:0002153)4.02304773
24Hyperlipoproteinemia (HP:0010980)4.01744279
25Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.01484934
26Attenuation of retinal blood vessels (HP:0007843)3.98581688
27Abnormality of the aortic arch (HP:0012303)3.83268496
28Abnormal rod and cone electroretinograms (HP:0008323)3.78446335
29Resting tremor (HP:0002322)3.74881795
30Infertility (HP:0000789)3.73001492
31Ketosis (HP:0001946)3.68763306
32Hypoplastic ischia (HP:0003175)3.66707808
33Hypercholesterolemia (HP:0003124)3.36324596
34Abnormality of pyrimidine metabolism (HP:0004353)3.34235507
35Renal dysplasia (HP:0000110)3.33144529
36Hypoglycemic coma (HP:0001325)3.30509067
37Potter facies (HP:0002009)3.26945861
38Facial shape deformation (HP:0011334)3.26945861
39Enlarged epiphyses (HP:0010580)3.25729056
40Hyperammonemia (HP:0001987)3.25050877
41Abnormality of the ischium (HP:0003174)3.21297599
42Hypolipoproteinemia (HP:0010981)3.19270769
43Hyperbilirubinemia (HP:0002904)3.08215063
44Abnormality of macular pigmentation (HP:0008002)3.07082968
45Aplasia/Hypoplasia of the earlobes (HP:0009906)3.04131461
46Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.02083005
47Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.01812713
48Bronchitis (HP:0012387)3.01015625
49Impulsivity (HP:0100710)2.99654135
50Complement deficiency (HP:0004431)2.94795193
51Congenital malformation of the right heart (HP:0011723)2.93072449
52Double outlet right ventricle (HP:0001719)2.93072449
53Atelectasis (HP:0100750)2.91167102
54Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.90502214
55Abnormal gallbladder physiology (HP:0012438)2.85847017
56Cholecystitis (HP:0001082)2.85847017
57Joint hemorrhage (HP:0005261)2.84085682
58Hyperthyroidism (HP:0000836)2.83605149
59Acanthocytosis (HP:0001927)2.82986196
60Epidermoid cyst (HP:0200040)2.81910001
61Abnormality of the intrinsic pathway (HP:0010989)2.77943156
62Abnormality of glutamine family amino acid metabolism (HP:0010902)2.77676810
63Bronchiectasis (HP:0002110)2.75646988
64Abnormality of the common coagulation pathway (HP:0010990)2.72612594
65Unilateral renal agenesis (HP:0000122)2.66623687
66Abnormal spermatogenesis (HP:0008669)2.66194009
67Hypoalphalipoproteinemia (HP:0003233)2.64443726
68Ketoacidosis (HP:0001993)2.62738826
69Fat malabsorption (HP:0002630)2.62203587
70Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.59788024
71Absent epiphyses (HP:0010577)2.59788024
72Abnormality of sulfur amino acid metabolism (HP:0004339)2.59692338
73Abnormality of fatty-acid metabolism (HP:0004359)2.57241414
74Delayed CNS myelination (HP:0002188)2.57142269
75Flattened epiphyses (HP:0003071)2.56692677
76Abnormality of methionine metabolism (HP:0010901)2.54782267
77Abnormal urine output (HP:0012590)2.53925885
78Abnormality of aspartate family amino acid metabolism (HP:0010899)2.51750522
79Hyperglycinemia (HP:0002154)2.49578771
80Recurrent sinusitis (HP:0011108)2.48933840
81Postural instability (HP:0002172)2.48172435
82Abnormality of nucleobase metabolism (HP:0010932)2.47646445
83Spontaneous abortion (HP:0005268)2.41742143
84Hyperglycinuria (HP:0003108)2.41329035
85Stage 5 chronic kidney disease (HP:0003774)2.41206935
86Abnormal biliary tract physiology (HP:0012439)2.40564149
87Bile duct proliferation (HP:0001408)2.40564149
88Abnormality of the parathyroid morphology (HP:0011766)2.40236163
89Cone-rod dystrophy (HP:0000548)2.38272072
90Myokymia (HP:0002411)2.37599205
91Dicarboxylic aciduria (HP:0003215)2.36257552
92Abnormality of dicarboxylic acid metabolism (HP:0010995)2.36257552
93Brushfield spots (HP:0001088)2.35804615
94Conjugated hyperbilirubinemia (HP:0002908)2.35142830
95Hyperinsulinemic hypoglycemia (HP:0000825)2.35012543
96Abnormality of glycine metabolism (HP:0010895)2.34719331
97Abnormality of serine family amino acid metabolism (HP:0010894)2.34719331
98Progressive sensorineural hearing impairment (HP:0000408)2.32258527
99Recurrent bronchitis (HP:0002837)2.30752654
100Late onset (HP:0003584)2.29355081
101Abnormality of the renal medulla (HP:0100957)2.29333408
102Generalized aminoaciduria (HP:0002909)2.29224327
103Occipital encephalocele (HP:0002085)2.29044033
104Renovascular hypertension (HP:0100817)2.28152248
105Abnormality of the heme biosynthetic pathway (HP:0010472)2.27986468
106Polydipsia (HP:0001959)2.26692862
107Abnormal drinking behavior (HP:0030082)2.26692862
108Recurrent otitis media (HP:0000403)2.23180498
109Abnormality of renal excretion (HP:0011036)2.19841716
110Abnormal number of erythroid precursors (HP:0012131)2.19119313
111Aplasia/Hypoplasia of the sacrum (HP:0008517)2.19107570
112Epiphyseal dysplasia (HP:0002656)2.18343367
113Hypoglycemic seizures (HP:0002173)2.17639291
114Metabolic acidosis (HP:0001942)2.17214804
115Malnutrition (HP:0004395)2.16985741
116Poikilocytosis (HP:0004447)2.14789185
117Abnormality of complement system (HP:0005339)2.13538389
118Abnormality of potassium homeostasis (HP:0011042)2.13358609
119Abnormality of the costochondral junction (HP:0000919)2.13064702
120Truncal obesity (HP:0001956)2.10812299
121Amblyopia (HP:0000646)2.08907276
122Hemorrhage of the eye (HP:0011885)2.06995451
123Bowel incontinence (HP:0002607)2.06376397
124Truncus arteriosus (HP:0001660)2.05670188
125Menorrhagia (HP:0000132)2.05645525
126Polyuria (HP:0000103)2.04968478
127Abnormality of purine metabolism (HP:0004352)2.04351914
128Abnormality of cells of the erythroid lineage (HP:0012130)2.03016402
129Gout (HP:0001997)2.02688487
130Tubulointerstitial abnormality (HP:0001969)2.01765484
131Abnormal ventriculo-arterial connection (HP:0011563)2.00076427
132Transposition of the great arteries (HP:0001669)2.00076427
133Abnormal connection of the cardiac segments (HP:0011545)2.00076427
134Abnormality of the epiphysis of the femoral head (HP:0010574)1.99339016
135Osteomalacia (HP:0002749)1.97814928
136Cerebellar dysplasia (HP:0007033)1.97813459
137Hypoparathyroidism (HP:0000829)1.97131140
138Male infertility (HP:0003251)1.96430950
139Progressive cerebellar ataxia (HP:0002073)1.91669912
140Abnormal large intestine physiology (HP:0012700)1.91298776
141Nephronophthisis (HP:0000090)1.90771168
142Abnormality of dental color (HP:0011073)1.90425954
143Azoospermia (HP:0000027)1.89196777
144Elevated hepatic transaminases (HP:0002910)1.88584089
145Amelogenesis imperfecta (HP:0000705)1.88069917
146Reticulocytosis (HP:0001923)1.88044139
147Abnormality of femoral epiphyses (HP:0006499)1.87727741
148Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.87727741
149Abnormality of the femoral head (HP:0003368)1.87530131
150Steatorrhea (HP:0002570)1.87318801
151Lethargy (HP:0001254)1.83886280
152Hyponatremia (HP:0002902)1.83568697
153Abnormality of serum amino acid levels (HP:0003112)1.82640620
154Abnormality of lateral ventricle (HP:0030047)1.81936018
155Gonadotropin excess (HP:0000837)1.81671142
156Flat capital femoral epiphysis (HP:0003370)1.81037792
157Tubulointerstitial nephritis (HP:0001970)1.81003921
158Menstrual irregularities (HP:0000858)1.78343474
159Vertebral clefting (HP:0008428)1.76298794
160Myoglobinuria (HP:0002913)1.76225377
161Abnormality of the pubic bones (HP:0003172)1.76105193
162Short ribs (HP:0000773)1.75825774
163Pancreatitis (HP:0001733)1.75200826
164Recurrent corneal erosions (HP:0000495)1.73718563
165Portal hypertension (HP:0001409)1.73117968
166Widely patent fontanelles and sutures (HP:0004492)1.71754395
167Chronic hepatic failure (HP:0100626)1.71560432
168Failure to thrive in infancy (HP:0001531)1.71445548
169Spastic paraparesis (HP:0002313)1.70797672
170Abnormality of transition element cation homeostasis (HP:0011030)1.70529377
171Skin nodule (HP:0200036)1.69762017
172Cerebral edema (HP:0002181)1.69339298
173Tubular atrophy (HP:0000092)1.68901589
174Neoplasm of the heart (HP:0100544)1.68229027
175Hypoplasia of the thymus (HP:0000778)1.67788222
176Abnormal gallbladder morphology (HP:0012437)1.66344706
177Spastic diplegia (HP:0001264)1.65279739
178Reduced antithrombin III activity (HP:0001976)1.65063239

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK46.60149129
2PDK45.18872821
3PDK35.18872821
4DDR24.88288550
5BCKDK3.46664602
6TESK13.34212069
7STK162.97087729
8ICK2.74359919
9ERN12.66462547
10PRKD32.57887620
11PDK22.56498750
12MAP4K22.54434403
13TAOK32.16007355
14FLT32.11698297
15PLK22.09268719
16EEF2K2.04432286
17PASK2.01180990
18EPHA32.00919583
19INSRR1.92709773
20MAPK151.92149344
21MST1R1.91421058
22SIK11.89816025
23WNK11.80088557
24MAP4K11.77899126
25NME21.71347313
26PDPK11.66487572
27STK38L1.53186795
28MAP2K31.47969539
29SIK21.47816940
30NEK21.46562505
31DYRK1B1.44670380
32FGFR41.39334738
33MAP2K61.37329874
34ZAP701.33754420
35DYRK31.31507606
36MARK21.29727509
37RPS6KA21.21742939
38CAMK1D1.20488920
39PKN21.19512513
40KDR1.19231055
41SCYL21.18229000
42WEE11.18224699
43TBK11.17475365
44BRAF1.15158823
45WNK41.12990801
46BTK1.08616005
47KIT1.07677355
48ACVR1B1.03261862
49TYRO31.00202132
50KSR20.98305337
51MAP3K90.97915243
52MAP3K100.97692025
53MAP2K20.97691275
54NEK60.97632731
55IKBKE0.95805732
56PIM20.94423806
57TGFBR10.91018790
58PTK2B0.90855067
59MAP3K30.90164719
60TYK20.87831432
61TEC0.86122013
62MAPK110.85714595
63CCNB10.84640446
64MUSK0.83307486
65MAP3K110.83098508
66BRD40.82935289
67AKT30.80522550
68ADRBK20.77037310
69MTOR0.76618857
70MAP2K40.76410200
71RPS6KA10.76276346
72PDK10.74443646
73VRK10.73298276
74PIK3CG0.71872730
75MAP3K60.71121982
76ATR0.70635611
77MAP3K80.70383338
78RPS6KL10.69973501
79RPS6KC10.69973501
80LATS20.69921963
81NTRK30.67313589
82MARK10.65449075
83JAK20.65334083
84SRPK10.64084403
85CSF1R0.61499773
86CDK70.61264762
87RIPK10.61141271
88RPS6KA60.61116694
89SGK4940.61006828
90SGK2230.61006828
91EPHA20.60950871
92UHMK10.60400584
93MAPKAPK50.59087333
94TRIB30.57959720
95ROCK10.57743620
96MAPKAPK30.57427301
97PRKG20.56398332
98CDC70.55245181
99CDK40.54260594
100MAPK80.54120753
101MAP2K70.53984127
102MAPK40.53913254
103BRSK20.53378004
104FRK0.53308198
105GSK3B0.53273485
106CDK20.52720565
107TNK20.51814797
108MAP3K20.51685735
109MAP3K10.51441416
110PRKG10.51265989
111GRK60.49410097
112ERBB20.48521795
113TLK10.48330959
114MET0.47804782
115TESK20.47663690
116TGFBR20.47121373
117RIPK40.46966261
118BLK0.46689279
119MAPK10.45949889
120IRAK10.45849096
121RPS6KB20.45151801
122DYRK20.44384736
123CDK190.44030461
124CDK10.43892928
125STK380.43807579
126RPS6KA40.43792689
127SYK0.42440286
128NTRK20.42048795
129PRKAA20.42020186
130CAMK1G0.41502541
131CAMK40.40494497
132CAMK10.39746831
133MAP3K70.38772289
134CHEK10.38314516
135PRKCZ0.38145888
136PAK20.36642858
137PINK10.36062653
138PNCK0.35999708
139RPS6KB10.34104782
140SGK10.34063244
141MAP3K50.33759991
142CDK30.33473025
143CSNK2A20.32450266
144PIM10.32198834
145MAPK100.31866408
146TXK0.31604911
147DAPK10.31260731
148CAMKK20.31179167
149TNIK0.30304908
150MAPK140.29730609
151LYN0.29664802
152CDK120.28749621
153PRKAA10.27604589
154AKT10.26218854
155STK390.25544623
156PTK60.25034760
157PRKCG0.24760469
158CDK11A0.23827902
159PKN10.22872711
160ARAF0.21772128
161MINK10.20879223
162LATS10.18047578
163AURKA0.17940932
164SGK30.15581770
165PRKCB0.13568441
166MAPK90.13066302
167PRKCH0.13062862

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.78356126
2Olfactory transduction_Homo sapiens_hsa047402.98984851
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.93596846
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.49529133
5Fatty acid degradation_Homo sapiens_hsa000712.48274063
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.32615622
7Arginine biosynthesis_Homo sapiens_hsa002202.30594609
8Tryptophan metabolism_Homo sapiens_hsa003802.29867661
9Propanoate metabolism_Homo sapiens_hsa006402.27952548
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.23368052
11Selenocompound metabolism_Homo sapiens_hsa004502.22519102
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.20628044
13Pyruvate metabolism_Homo sapiens_hsa006202.17377365
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.14121161
15Nitrogen metabolism_Homo sapiens_hsa009102.11938560
16Drug metabolism - other enzymes_Homo sapiens_hsa009832.04717352
17Maturity onset diabetes of the young_Homo sapiens_hsa049502.03174439
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.00803675
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.97957450
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96335033
21Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.93292597
22Peroxisome_Homo sapiens_hsa041461.93292206
23Complement and coagulation cascades_Homo sapiens_hsa046101.89672536
24PPAR signaling pathway_Homo sapiens_hsa033201.83353694
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.82444421
26Chemical carcinogenesis_Homo sapiens_hsa052041.79229786
27Caffeine metabolism_Homo sapiens_hsa002321.78915665
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.78043076
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.74410329
30Fatty acid metabolism_Homo sapiens_hsa012121.68969704
31Folate biosynthesis_Homo sapiens_hsa007901.62935179
32Biosynthesis of amino acids_Homo sapiens_hsa012301.60871207
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.59686393
34Type II diabetes mellitus_Homo sapiens_hsa049301.58138300
35Pentose phosphate pathway_Homo sapiens_hsa000301.57709680
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.56571534
37Butanoate metabolism_Homo sapiens_hsa006501.53414399
38Carbon metabolism_Homo sapiens_hsa012001.51628855
39Histidine metabolism_Homo sapiens_hsa003401.50220557
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.49400772
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47993224
42Fat digestion and absorption_Homo sapiens_hsa049751.46024698
43Retinol metabolism_Homo sapiens_hsa008301.43507783
44Endocytosis_Homo sapiens_hsa041441.42162658
45beta-Alanine metabolism_Homo sapiens_hsa004101.41867814
46Sulfur metabolism_Homo sapiens_hsa009201.40910395
47Sulfur relay system_Homo sapiens_hsa041221.39729375
48ABC transporters_Homo sapiens_hsa020101.33928085
49Dorso-ventral axis formation_Homo sapiens_hsa043201.33225923
50Bile secretion_Homo sapiens_hsa049761.31421804
51Taste transduction_Homo sapiens_hsa047421.30369267
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.30005180
53Starch and sucrose metabolism_Homo sapiens_hsa005001.21295421
54Hedgehog signaling pathway_Homo sapiens_hsa043401.20347300
55Notch signaling pathway_Homo sapiens_hsa043301.20119827
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.20032369
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.15949890
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.14757307
59Phenylalanine metabolism_Homo sapiens_hsa003601.13903991
60Vitamin B6 metabolism_Homo sapiens_hsa007501.11730070
61VEGF signaling pathway_Homo sapiens_hsa043701.10776654
62Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08065052
63Fatty acid biosynthesis_Homo sapiens_hsa000611.05448506
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04447537
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04146112
66Staphylococcus aureus infection_Homo sapiens_hsa051501.01958058
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98161774
68Tyrosine metabolism_Homo sapiens_hsa003500.97943605
69One carbon pool by folate_Homo sapiens_hsa006700.96692518
70Estrogen signaling pathway_Homo sapiens_hsa049150.95024216
71Fatty acid elongation_Homo sapiens_hsa000620.94520912
72Allograft rejection_Homo sapiens_hsa053300.92823305
73Type I diabetes mellitus_Homo sapiens_hsa049400.92146890
74Inositol phosphate metabolism_Homo sapiens_hsa005620.91864654
75Glycerolipid metabolism_Homo sapiens_hsa005610.91772316
76Lysine degradation_Homo sapiens_hsa003100.91464609
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91068781
78Autoimmune thyroid disease_Homo sapiens_hsa053200.90932906
79Acute myeloid leukemia_Homo sapiens_hsa052210.90920091
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.90583288
81Linoleic acid metabolism_Homo sapiens_hsa005910.90464707
82Pyrimidine metabolism_Homo sapiens_hsa002400.89158146
83cAMP signaling pathway_Homo sapiens_hsa040240.88986081
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87216614
85Synaptic vesicle cycle_Homo sapiens_hsa047210.83956942
86Glutathione metabolism_Homo sapiens_hsa004800.83909800
87DNA replication_Homo sapiens_hsa030300.82966167
88Arginine and proline metabolism_Homo sapiens_hsa003300.81854281
89Salivary secretion_Homo sapiens_hsa049700.81614908
90Graft-versus-host disease_Homo sapiens_hsa053320.80849672
91Morphine addiction_Homo sapiens_hsa050320.77391836
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77166428
93Vitamin digestion and absorption_Homo sapiens_hsa049770.76417168
94Phototransduction_Homo sapiens_hsa047440.75109761
95Fructose and mannose metabolism_Homo sapiens_hsa000510.74393225
96RNA transport_Homo sapiens_hsa030130.73685249
97Protein digestion and absorption_Homo sapiens_hsa049740.73268516
98Viral myocarditis_Homo sapiens_hsa054160.72415096
99Calcium signaling pathway_Homo sapiens_hsa040200.70908095
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70042604
101Circadian entrainment_Homo sapiens_hsa047130.69429558
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69106248
103Metabolic pathways_Homo sapiens_hsa011000.68789425
104Tight junction_Homo sapiens_hsa045300.68405592
105MAPK signaling pathway_Homo sapiens_hsa040100.68385907
106Ribosome_Homo sapiens_hsa030100.68368652
107Insulin secretion_Homo sapiens_hsa049110.67146437
108Cardiac muscle contraction_Homo sapiens_hsa042600.65701854
109Glucagon signaling pathway_Homo sapiens_hsa049220.64255551
110Galactose metabolism_Homo sapiens_hsa000520.63353871
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61690371
112Influenza A_Homo sapiens_hsa051640.59200191
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58976220
114Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58898600
115Protein export_Homo sapiens_hsa030600.54265554
116Gastric acid secretion_Homo sapiens_hsa049710.54070541
117Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52870345
118Cholinergic synapse_Homo sapiens_hsa047250.50940043
119Basal cell carcinoma_Homo sapiens_hsa052170.50463264
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50311908
121Oocyte meiosis_Homo sapiens_hsa041140.49590546
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48828770
123Prolactin signaling pathway_Homo sapiens_hsa049170.46597323
124Purine metabolism_Homo sapiens_hsa002300.45552501
125Glutamatergic synapse_Homo sapiens_hsa047240.44446613
126N-Glycan biosynthesis_Homo sapiens_hsa005100.42639427
127Choline metabolism in cancer_Homo sapiens_hsa052310.41438499
128mTOR signaling pathway_Homo sapiens_hsa041500.41356697
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.39349641
130Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39171817
131mRNA surveillance pathway_Homo sapiens_hsa030150.38755206
132Melanogenesis_Homo sapiens_hsa049160.37507150
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.37501109
134Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35613352
135Cocaine addiction_Homo sapiens_hsa050300.35296113
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.34980189
137Adipocytokine signaling pathway_Homo sapiens_hsa049200.34905956
138Axon guidance_Homo sapiens_hsa043600.34087256
139ErbB signaling pathway_Homo sapiens_hsa040120.32424276
140Huntingtons disease_Homo sapiens_hsa050160.31978519
141Insulin signaling pathway_Homo sapiens_hsa049100.31774011
142Mismatch repair_Homo sapiens_hsa034300.31180433
143Glycosaminoglycan degradation_Homo sapiens_hsa005310.31025255
144Oxytocin signaling pathway_Homo sapiens_hsa049210.30778307
145Nicotine addiction_Homo sapiens_hsa050330.30232978
146Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29385241
147Viral carcinogenesis_Homo sapiens_hsa052030.29180930
148Renin-angiotensin system_Homo sapiens_hsa046140.28085350
149Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25974770
150Basal transcription factors_Homo sapiens_hsa030220.24537095
151Hippo signaling pathway_Homo sapiens_hsa043900.23542242
152Thyroid hormone synthesis_Homo sapiens_hsa049180.23499860
153Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.21917800
154Insulin resistance_Homo sapiens_hsa049310.21812140
155Base excision repair_Homo sapiens_hsa034100.20988489
156Steroid biosynthesis_Homo sapiens_hsa001000.19181505
157Antigen processing and presentation_Homo sapiens_hsa046120.16891266
158Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.11187125
159Non-homologous end-joining_Homo sapiens_hsa034500.10987785
160Nucleotide excision repair_Homo sapiens_hsa034200.09368530
161AMPK signaling pathway_Homo sapiens_hsa041520.09161399
162Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.08297801
163Central carbon metabolism in cancer_Homo sapiens_hsa052300.07287435
164Systemic lupus erythematosus_Homo sapiens_hsa053220.06584582
165RNA degradation_Homo sapiens_hsa030180.06269694

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