PCSK6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)6.85560842
2L-phenylalanine catabolic process (GO:0006559)6.80619113
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.80619113
4L-phenylalanine metabolic process (GO:0006558)6.51843410
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.51843410
6blood coagulation, intrinsic pathway (GO:0007597)6.19687154
7aromatic amino acid family catabolic process (GO:0009074)5.93369916
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.69937188
9epoxygenase P450 pathway (GO:0019373)5.63823897
10alpha-linolenic acid metabolic process (GO:0036109)5.50019869
11kynurenine metabolic process (GO:0070189)5.32081486
12bile acid biosynthetic process (GO:0006699)5.28795740
13glyoxylate metabolic process (GO:0046487)5.26886025
14omega-hydroxylase P450 pathway (GO:0097267)5.21036972
15tryptophan catabolic process (GO:0006569)5.19692773
16indole-containing compound catabolic process (GO:0042436)5.19692773
17indolalkylamine catabolic process (GO:0046218)5.19692773
18sulfur amino acid catabolic process (GO:0000098)5.11431790
19protein carboxylation (GO:0018214)5.10542080
20peptidyl-glutamic acid carboxylation (GO:0017187)5.10542080
21regulation of protein activation cascade (GO:2000257)5.09584960
22negative regulation of fibrinolysis (GO:0051918)5.03229686
23complement activation, alternative pathway (GO:0006957)5.02296961
24tryptophan metabolic process (GO:0006568)4.87033446
25regulation of fibrinolysis (GO:0051917)4.86830043
26urea metabolic process (GO:0019627)4.85194465
27urea cycle (GO:0000050)4.85194465
28regulation of complement activation (GO:0030449)4.84749904
29cysteine metabolic process (GO:0006534)4.82253732
30negative regulation of hemostasis (GO:1900047)4.77827970
31negative regulation of blood coagulation (GO:0030195)4.77827970
32high-density lipoprotein particle remodeling (GO:0034375)4.75272449
33regulation of plasminogen activation (GO:0010755)4.75202922
34intestinal cholesterol absorption (GO:0030299)4.75145412
35serine family amino acid catabolic process (GO:0009071)4.71738407
36homocysteine metabolic process (GO:0050667)4.68797656
37very-low-density lipoprotein particle assembly (GO:0034379)4.63159870
38bile acid metabolic process (GO:0008206)4.56785433
39lysine metabolic process (GO:0006553)4.51839679
40lysine catabolic process (GO:0006554)4.51839679
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.49802419
42regulation of triglyceride catabolic process (GO:0010896)4.49773225
43nitrogen cycle metabolic process (GO:0071941)4.44454300
44amino-acid betaine metabolic process (GO:0006577)4.42140710
45positive regulation of hemostasis (GO:1900048)4.40354363
46positive regulation of blood coagulation (GO:0030194)4.40354363
47protein activation cascade (GO:0072376)4.32563939
48negative regulation of coagulation (GO:0050819)4.32457258
49low-density lipoprotein particle remodeling (GO:0034374)4.31016305
50alpha-amino acid catabolic process (GO:1901606)4.30457337
51acylglycerol homeostasis (GO:0055090)4.28016525
52triglyceride homeostasis (GO:0070328)4.28016525
53aromatic amino acid family metabolic process (GO:0009072)4.27264732
54reverse cholesterol transport (GO:0043691)4.24726946
55drug metabolic process (GO:0017144)4.22403888
56coenzyme catabolic process (GO:0009109)4.20336826
57cellular ketone body metabolic process (GO:0046950)4.20045583
58positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.15350732
59negative regulation of wound healing (GO:0061045)4.15031146
60tyrosine metabolic process (GO:0006570)4.11770515
61regulation of cholesterol esterification (GO:0010872)4.11515553
62protein-lipid complex remodeling (GO:0034368)4.10542264
63macromolecular complex remodeling (GO:0034367)4.10542264
64plasma lipoprotein particle remodeling (GO:0034369)4.10542264
65cellular amino acid catabolic process (GO:0009063)4.05036136
66plasma lipoprotein particle clearance (GO:0034381)4.03302119
67positive regulation of coagulation (GO:0050820)4.02581957
68ethanol oxidation (GO:0006069)4.01646148
69oxidative demethylation (GO:0070989)4.00671842
70negative regulation of cholesterol transport (GO:0032375)3.97990319
71negative regulation of sterol transport (GO:0032372)3.97990319
72cellular modified amino acid catabolic process (GO:0042219)3.95980145
73glutamate metabolic process (GO:0006536)3.95130940
74plasma lipoprotein particle organization (GO:0071827)3.94814880
75glycine metabolic process (GO:0006544)3.93581223
76positive regulation of fatty acid beta-oxidation (GO:0032000)3.93580880
77cellular glucuronidation (GO:0052695)3.88094272
78flavonoid metabolic process (GO:0009812)3.87992061
79bile acid and bile salt transport (GO:0015721)3.87924568
80phospholipid efflux (GO:0033700)3.86970708
81acetyl-CoA metabolic process (GO:0006084)3.86540813
82positive regulation of triglyceride lipase activity (GO:0061365)3.85314996
83positive regulation of lipoprotein lipase activity (GO:0051006)3.85314996
84acute-phase response (GO:0006953)3.83170270
85dicarboxylic acid biosynthetic process (GO:0043650)3.82330620
86fibrinolysis (GO:0042730)3.81506876
87serine family amino acid metabolic process (GO:0009069)3.76119718
88short-chain fatty acid metabolic process (GO:0046459)3.75902734
89protein-lipid complex subunit organization (GO:0071825)3.74620107
90negative regulation of protein activation cascade (GO:2000258)3.72797617
91regulation of humoral immune response (GO:0002920)3.72090221
92regulation of cholesterol homeostasis (GO:2000188)3.70042937
93aspartate family amino acid catabolic process (GO:0009068)3.69835752
94fatty acid beta-oxidation (GO:0006635)3.69542424
95positive regulation of lipid catabolic process (GO:0050996)3.67236314
96organic acid catabolic process (GO:0016054)3.63394730
97carboxylic acid catabolic process (GO:0046395)3.63394730
98cholesterol efflux (GO:0033344)3.62697729
99regulation of apoptotic cell clearance (GO:2000425)3.61983815
100protein-lipid complex assembly (GO:0065005)3.61950056
101phospholipid homeostasis (GO:0055091)3.60807597
102indolalkylamine metabolic process (GO:0006586)3.60712380
103imidazole-containing compound metabolic process (GO:0052803)3.60665375
104benzene-containing compound metabolic process (GO:0042537)3.60154857
105ketone body metabolic process (GO:1902224)3.59932464
106fatty acid oxidation (GO:0019395)3.58244248
107amine catabolic process (GO:0009310)3.56370665
108cellular biogenic amine catabolic process (GO:0042402)3.56370665
109heme transport (GO:0015886)3.55721545
110arginine metabolic process (GO:0006525)3.53066764
111lipid oxidation (GO:0034440)3.52385271
112monocarboxylic acid catabolic process (GO:0072329)3.52263415
1132-oxoglutarate metabolic process (GO:0006103)3.51112597
114serine family amino acid biosynthetic process (GO:0009070)3.51096871
115fatty acid catabolic process (GO:0009062)3.49988571
116positive regulation of fatty acid oxidation (GO:0046321)3.49521891
117cholesterol homeostasis (GO:0042632)3.48110686
118drug catabolic process (GO:0042737)3.47100630
119negative regulation of lipase activity (GO:0060192)3.45525649
120regulation of bile acid biosynthetic process (GO:0070857)3.44105655
121complement activation (GO:0006956)3.42629823
122sterol homeostasis (GO:0055092)3.42367710
123phenylpropanoid metabolic process (GO:0009698)3.42071015
124carnitine metabolic process (GO:0009437)3.40536683
125plasma lipoprotein particle assembly (GO:0034377)3.40082646
126opsonization (GO:0008228)3.40081391
127complement activation, classical pathway (GO:0006958)3.39616419
128uronic acid metabolic process (GO:0006063)3.37595989
129glucuronate metabolic process (GO:0019585)3.37595989
130ethanol metabolic process (GO:0006067)3.36008437
131lipoprotein metabolic process (GO:0042157)3.33013090
132cytolysis (GO:0019835)3.30709993
133regulation of cholesterol biosynthetic process (GO:0045540)3.29486650
134sodium-independent organic anion transport (GO:0043252)3.27187332
135response to mercury ion (GO:0046689)3.24925444
136negative regulation of lipid transport (GO:0032369)3.20084403
137S-adenosylmethionine metabolic process (GO:0046500)3.18564236
138cholesterol transport (GO:0030301)3.16888377
139sterol transport (GO:0015918)3.16888377

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.29745694
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.26345501
3* LXR_22158963_ChIP-Seq_LIVER_Mouse5.79495885
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.44472074
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.32765263
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.61516758
7* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.97083878
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.79082562
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.73933167
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33580591
11CLOCK_20551151_ChIP-Seq_293T_Human2.25387508
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.2148640
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.91147946
14RARG_19884340_ChIP-ChIP_MEFs_Mouse1.86620258
15TRIM28_21343339_ChIP-Seq_HEK293_Human1.84090609
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.81701931
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.70657987
18* FOXA2_19822575_ChIP-Seq_HepG2_Human1.68346220
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62574401
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.54186914
21* ESR2_21235772_ChIP-Seq_MCF-7_Human1.49302327
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40876364
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40819673
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.30444797
25* HNF4A_19822575_ChIP-Seq_HepG2_Human1.27341624
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.22802775
27ZNF263_19887448_ChIP-Seq_K562_Human1.20732561
28HTT_18923047_ChIP-ChIP_STHdh_Human1.18686783
29* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16075598
30GBX2_23144817_ChIP-Seq_PC3_Human1.14864591
31SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14648171
32* ESR1_21235772_ChIP-Seq_MCF-7_Human1.14156025
33SALL4_18804426_ChIP-ChIP_XEN_Mouse1.13522748
34DROSHA_22980978_ChIP-Seq_HELA_Human1.12447583
35TP63_17297297_ChIP-ChIP_HaCaT_Human1.12407917
36ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12191918
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09683159
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08827399
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07350245
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06367280
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06280765
42* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03708016
43GATA1_22025678_ChIP-Seq_K562_Human1.02626630
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02515158
45NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00299425
46* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00073991
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99671424
48ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99612928
49CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98856210
50EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97962931
51RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97962931
52RXRA_24833708_ChIP-Seq_LIVER_Mouse0.96455509
53NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95929320
54NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95929320
55ESR1_20079471_ChIP-ChIP_T-47D_Human0.94306564
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93569673
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92184143
58SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.92155430
59EP300_21415370_ChIP-Seq_HL-1_Mouse0.90828828
60SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.90394639
61EED_16625203_ChIP-ChIP_MESCs_Mouse0.89898481
62ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89680827
63EZH2_27294783_Chip-Seq_ESCs_Mouse0.89048899
64TBX20_22080862_ChIP-Seq_HEART_Mouse0.88367787
65TBX20_22328084_ChIP-Seq_HEART_Mouse0.88367787
66* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88005659
67JARID2_20075857_ChIP-Seq_MESCs_Mouse0.87839729
68GATA4_25053715_ChIP-Seq_YYC3_Human0.87395002
69FOXO3_23340844_ChIP-Seq_DLD1_Human0.86855013
70* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86512382
71GATA1_19941827_ChIP-Seq_MEL_Mouse0.86447724
72AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86399716
73AHR_22903824_ChIP-Seq_MCF-7_Human0.83933375
74SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.81654606
75CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.81458157
76SUZ12_27294783_Chip-Seq_ESCs_Mouse0.81254713
77STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80020402
78* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.79610324
79AR_21572438_ChIP-Seq_LNCaP_Human0.77110879
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.77039502
81SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76808658
82CTNNB1_20460455_ChIP-Seq_HCT116_Human0.76050631
83GATA2_21666600_ChIP-Seq_HMVEC_Human0.75900496
84SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.75152563
85SMAD4_21741376_ChIP-Seq_HESCs_Human0.74134798
86* ERG_21242973_ChIP-ChIP_JURKAT_Human0.74001904
87* LXR_22292898_ChIP-Seq_THP-1_Human0.73227979
88TCF3_18692474_ChIP-Seq_MEFs_Mouse0.72510330
89NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.72215509
90EZH2_22144423_ChIP-Seq_EOC_Human0.71415074
91* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.71049799
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70995129
93PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.70946904
94GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.70116328
95SOX2_21211035_ChIP-Seq_LN229_Human0.69893419
96SMC4_20622854_ChIP-Seq_HELA_Human0.69828340
97* GATA2_19941826_ChIP-Seq_K562_Human0.69733532
98EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.68822321
99JARID2_20064375_ChIP-Seq_MESCs_Mouse0.67967209
100ARNT_22903824_ChIP-Seq_MCF-7_Human0.67553337
101TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.67243262
102DNAJC2_21179169_ChIP-ChIP_NT2_Human0.67087421
103POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.66666946
104RACK7_27058665_Chip-Seq_MCF-7_Human0.65234454
105SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.65230781
106GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.64939603
107KAP1_22055183_ChIP-Seq_ESCs_Mouse0.64866742
108PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.64467954
109FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.64116679
110ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.63595944
111TP53_16413492_ChIP-PET_HCT116_Human0.63586888
112RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63581504
113FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.63296974
114SRY_22984422_ChIP-ChIP_TESTIS_Rat0.63211395
115SOX9_24532713_ChIP-Seq_HFSC_Mouse0.61773784
116CJUN_26792858_Chip-Seq_BT549_Human0.60292326
117NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.60201357
118PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.59865261
119RARA_24833708_ChIP-Seq_LIVER_Mouse0.59054215
120BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.58733342
121CDX2_20551321_ChIP-Seq_CACO-2_Human0.58229740
122GATA3_24758297_ChIP-Seq_MCF-7_Human0.58047819
123BCAT_22108803_ChIP-Seq_LS180_Human0.56607594
124GATA1_19941826_ChIP-Seq_K562_Human0.55201887
125FOXA1_25552417_ChIP-Seq_VCAP_Human0.54867664
126STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.54789103
127P63_26484246_Chip-Seq_KERATINOCYTES_Human0.54779970
128* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.54448453
129* SOX2_20726797_ChIP-Seq_SW620_Human0.54284377
130PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.54177790
131RARB_24833708_ChIP-Seq_LIVER_Mouse0.54021358
132CEBPB_22108803_ChIP-Seq_LS180_Human0.53826261
133GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.52560102
134* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.51895529
135CTCF_27219007_Chip-Seq_Bcells_Human0.51774869
136SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.51287626
137CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.50731843
138PIAS1_25552417_ChIP-Seq_VCAP_Human0.50014883
139CSB_26484114_Chip-Seq_FIBROBLAST_Human0.50013954
140ESET_19884257_ChIP-Seq_ESCs_Mouse0.48665414
141GATA6_25053715_ChIP-Seq_YYC3_Human0.48389630
142KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.47878693
143KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.47878693
144KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.47878693
145SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.47718267

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.36067999
2MP0005360_urolithiasis6.51560624
3MP0005085_abnormal_gallbladder_physiolo5.72282079
4MP0005365_abnormal_bile_salt5.50008090
5MP0008875_abnormal_xenobiotic_pharmacok4.44485303
6MP0003806_abnormal_nucleotide_metabolis4.34036744
7MP0003252_abnormal_bile_duct3.73428257
8MP0010329_abnormal_lipoprotein_level3.28444714
9MP0009840_abnormal_foam_cell2.94645752
10MP0003195_calcinosis2.77513856
11MP0005332_abnormal_amino_acid2.71491977
12MP0005083_abnormal_biliary_tract2.71253282
13MP0008438_abnormal_cutaneous_collagen2.37313957
14MP0003705_abnormal_hypodermis_morpholog2.30621645
15MP0001666_abnormal_nutrient_absorption2.15949976
16MP0002118_abnormal_lipid_homeostasis2.07013760
17MP0005275_abnormal_skin_tensile1.93984436
18MP0000609_abnormal_liver_physiology1.90655227
19MP0004019_abnormal_vitamin_homeostasis1.87949629
20MP0003191_abnormal_cellular_cholesterol1.83949159
21MP0000566_synostosis1.68251271
22MP0005319_abnormal_enzyme/_coenzyme1.67629807
23MP0002138_abnormal_hepatobiliary_system1.55967928
24MP0005464_abnormal_platelet_physiology1.53212631
25MP0003879_abnormal_hair_cell1.49609288
26MP0002837_dystrophic_cardiac_calcinosis1.49592050
27MP0005451_abnormal_body_composition1.48412557
28MP0003868_abnormal_feces_composition1.43142144
29MP0010368_abnormal_lymphatic_system1.34972426
30MP0005670_abnormal_white_adipose1.33619849
31MP0009780_abnormal_chondrocyte_physiolo1.33316161
32MP0005584_abnormal_enzyme/coenzyme_acti1.33301490
33MP0005646_abnormal_pituitary_gland1.33272125
34MP0005058_abnormal_lysosome_morphology1.31446634
35MP0005503_abnormal_tendon_morphology1.29485108
36MP0005167_abnormal_blood-brain_barrier1.29198722
37MP0003011_delayed_dark_adaptation1.27360480
38MP0003122_maternal_imprinting1.23582424
39MP0001764_abnormal_homeostasis1.19259920
40MP0009643_abnormal_urine_homeostasis1.16635443
41MP0004130_abnormal_muscle_cell1.14537580
42MP0001661_extended_life_span1.14211069
43MP0002089_abnormal_postnatal_growth/wei1.14005255
44MP0005666_abnormal_adipose_tissue1.13659381
45MP0002254_reproductive_system_inflammat1.12740019
46MP0003186_abnormal_redox_activity1.06927118
47MP0004272_abnormal_basement_membrane1.06343755
48MP0004185_abnormal_adipocyte_glucose1.02054296
49MP0003638_abnormal_response/metabolism_0.98754925
50MP0000920_abnormal_myelination0.96061768
51MP0005647_abnormal_sex_gland0.95425479
52MP0000598_abnormal_liver_morphology0.94531403
53MP0002060_abnormal_skin_morphology0.93567884
54MP0009697_abnormal_copulation0.90856885
55MP0003690_abnormal_glial_cell0.89645915
56MP0001915_intracranial_hemorrhage0.88931319
57MP0000604_amyloidosis0.87542277
58MP0002796_impaired_skin_barrier0.87400046
59MP0002971_abnormal_brown_adipose0.83612336
60MP0009384_cardiac_valve_regurgitation0.83173018
61MP0005330_cardiomyopathy0.82878837
62MP0003656_abnormal_erythrocyte_physiolo0.80788177
63MP0003329_amyloid_beta_deposits0.80070619
64MP0005409_darkened_coat_color0.79204629
65MP0005187_abnormal_penis_morphology0.78813210
66MP0006036_abnormal_mitochondrial_physio0.77810614
67MP0008872_abnormal_physiological_respon0.75345273
68MP0009763_increased_sensitivity_to0.75202320
69MP0002282_abnormal_trachea_morphology0.74526372
70MP0000579_abnormal_nail_morphology0.74418950
71MP0009053_abnormal_anal_canal0.71427552
72MP0002078_abnormal_glucose_homeostasis0.71424467
73* MP0003632_abnormal_nervous_system0.70830509
74MP0005376_homeostasis/metabolism_phenot0.69949540
75MP0005375_adipose_tissue_phenotype0.68417334
76MP0005334_abnormal_fat_pad0.67424101
77MP0003633_abnormal_nervous_system0.67094445
78MP0005266_abnormal_metabolism0.66728476
79MP0005551_abnormal_eye_electrophysiolog0.66365139
80MP0002295_abnormal_pulmonary_circulatio0.66290193
81MP0001756_abnormal_urination0.65644234
82MP0009642_abnormal_blood_homeostasis0.65581833
83MP0002269_muscular_atrophy0.64956991
84MP0002108_abnormal_muscle_morphology0.64695674
85MP0003123_paternal_imprinting0.64546774
86MP0002064_seizures0.63134085
87MP0000751_myopathy0.62866432
88MP0005636_abnormal_mineral_homeostasis0.61633507
89MP0001243_abnormal_dermal_layer0.61144542
90MP0002132_abnormal_respiratory_system0.60685969
91MP0005023_abnormal_wound_healing0.58596728
92MP0005410_abnormal_fertilization0.58472421
93* MP0003631_nervous_system_phenotype0.58235588
94MP0004043_abnormal_pH_regulation0.57992459
95MP0003953_abnormal_hormone_level0.57484936
96MP0009764_decreased_sensitivity_to0.56107114
97MP0004084_abnormal_cardiac_muscle0.54572957
98MP0006138_congestive_heart_failure0.54468221
99MP0005248_abnormal_Harderian_gland0.53754721
100MP0003646_muscle_fatigue0.53436832
101MP0005220_abnormal_exocrine_pancreas0.53383327
102MP0004036_abnormal_muscle_relaxation0.53009557
103MP0006035_abnormal_mitochondrial_morpho0.52638120
104MP0005535_abnormal_body_temperature0.51845891
105MP0000639_abnormal_adrenal_gland0.51230713
106MP0002168_other_aberrant_phenotype0.51023122
107MP0001542_abnormal_bone_strength0.50744911
108MP0005448_abnormal_energy_balance0.50229875
109MP0008004_abnormal_stomach_pH0.50147935
110MP0005395_other_phenotype0.50013204
111MP0002249_abnormal_larynx_morphology0.49621778
112MP0002909_abnormal_adrenal_gland0.48336261
113MP0003566_abnormal_cell_adhesion0.48214245
114MP0008874_decreased_physiological_sensi0.47658504
115MP0009115_abnormal_fat_cell0.47342344
116MP0005408_hypopigmentation0.47191967
117MP0002160_abnormal_reproductive_system0.45441178
118MP0004270_analgesia0.44788707
119MP0000230_abnormal_systemic_arterial0.44322757
120MP0001544_abnormal_cardiovascular_syste0.44051207
121MP0005385_cardiovascular_system_phenoty0.44051207
122MP0004087_abnormal_muscle_fiber0.43830996
123MP0000003_abnormal_adipose_tissue0.43425081
124MP0002876_abnormal_thyroid_physiology0.42830449
125MP0002136_abnormal_kidney_physiology0.42076145
126MP0009765_abnormal_xenobiotic_induced0.42012207
127MP0005084_abnormal_gallbladder_morpholo0.41861433
128MP0004142_abnormal_muscle_tone0.41733433
129MP0003279_aneurysm0.41681228
130MP0003075_altered_response_to0.41478108
131MP0004134_abnormal_chest_morphology0.41428096
132MP0008775_abnormal_heart_ventricle0.40834291
133MP0010234_abnormal_vibrissa_follicle0.40732780
134MP0000249_abnormal_blood_vessel0.38935694
135MP0001486_abnormal_startle_reflex0.38122462
136MP0002272_abnormal_nervous_system0.36381730
137MP0002128_abnormal_blood_circulation0.36012881
138MP0002735_abnormal_chemical_nociception0.35183574
139MP0001440_abnormal_grooming_behavior0.32005146
140MP0003942_abnormal_urinary_system0.31338919
141MP0003718_maternal_effect0.31151865

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.78923627
2Deep venous thrombosis (HP:0002625)6.72819175
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.30702908
4Xanthomatosis (HP:0000991)5.94270267
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.86081223
6Hypobetalipoproteinemia (HP:0003563)5.35713193
7Prolonged partial thromboplastin time (HP:0003645)5.34544812
8Hyperlipoproteinemia (HP:0010980)5.28463039
9Complement deficiency (HP:0004431)4.93091278
10Menorrhagia (HP:0000132)4.52199365
11Hyperammonemia (HP:0001987)4.50508759
12Hypolipoproteinemia (HP:0010981)4.39077888
13Hyperglycinemia (HP:0002154)4.33571330
14Hyperglycinuria (HP:0003108)4.25130625
15Epidermoid cyst (HP:0200040)4.21870317
16Hypoalphalipoproteinemia (HP:0003233)4.19404949
17Ketosis (HP:0001946)4.18411712
18Abnormality of glycine metabolism (HP:0010895)4.17053238
19Abnormality of serine family amino acid metabolism (HP:0010894)4.17053238
20Purpura (HP:0000979)4.10832664
21Hypoglycemic coma (HP:0001325)4.06317882
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.06000206
23Gingival bleeding (HP:0000225)3.89828261
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.87034332
25Abnormality of sulfur amino acid metabolism (HP:0004339)3.79795622
26Abnormality of the common coagulation pathway (HP:0010990)3.73556227
27Abnormality of methionine metabolism (HP:0010901)3.72909516
28Joint hemorrhage (HP:0005261)3.66903252
29Abnormality of aspartate family amino acid metabolism (HP:0010899)3.65275552
30Abnormality of fatty-acid metabolism (HP:0004359)3.63173663
31Fat malabsorption (HP:0002630)3.58671124
32Abnormality of complement system (HP:0005339)3.53269719
33Abnormality of the intrinsic pathway (HP:0010989)3.38961392
34Ketoacidosis (HP:0001993)3.26034777
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.25048349
36Skin nodule (HP:0200036)3.20784102
37Hypercholesterolemia (HP:0003124)3.18617858
38Delayed CNS myelination (HP:0002188)3.08087730
39Conjugated hyperbilirubinemia (HP:0002908)2.94902045
40Increased mean platelet volume (HP:0011877)2.86279867
41Abnormality of pyrimidine metabolism (HP:0004353)2.85995758
42Hyperbilirubinemia (HP:0002904)2.85767416
43Mitral stenosis (HP:0001718)2.84607700
44Abnormality of serum amino acid levels (HP:0003112)2.81480124
45Myocardial infarction (HP:0001658)2.78604680
46Abnormality of dicarboxylic acid metabolism (HP:0010995)2.75989730
47Dicarboxylic aciduria (HP:0003215)2.75989730
48Arthropathy (HP:0003040)2.69257326
49Steatorrhea (HP:0002570)2.64236942
50Hepatocellular carcinoma (HP:0001402)2.61892991
51Abnormality of nucleobase metabolism (HP:0010932)2.60929414
52Metabolic acidosis (HP:0001942)2.53171567
53Hypochromic microcytic anemia (HP:0004840)2.51397448
54Lethargy (HP:0001254)2.48941382
55Abnormality of purine metabolism (HP:0004352)2.48396242
56Osteomalacia (HP:0002749)2.47692149
57Poikilocytosis (HP:0004447)2.47427917
58Vascular calcification (HP:0004934)2.46060986
59Cardiovascular calcification (HP:0011915)2.44691615
60Abnormal platelet volume (HP:0011876)2.44689170
61Epistaxis (HP:0000421)2.44139277
62Abnormal gallbladder morphology (HP:0012437)2.43730633
63Systemic lupus erythematosus (HP:0002725)2.41046042
64Recurrent gram-negative bacterial infections (HP:0005420)2.37612779
65Hypoglycemic seizures (HP:0002173)2.37468242
66Gout (HP:0001997)2.37407248
67Cholelithiasis (HP:0001081)2.35586604
68Hyperinsulinemic hypoglycemia (HP:0000825)2.32870077
69Thrombophlebitis (HP:0004418)2.30888856
70Spontaneous abortion (HP:0005268)2.28818817
71Glomerulonephritis (HP:0000099)2.27626855
72Facial shape deformation (HP:0011334)2.27051773
73Potter facies (HP:0002009)2.27051773
74Abnormality of proline metabolism (HP:0010907)2.26711234
75Hydroxyprolinuria (HP:0003080)2.26711234
76Cerebral edema (HP:0002181)2.24782951
77Spastic diplegia (HP:0001264)2.24456524
78Malnutrition (HP:0004395)2.22515472
79Abnormal cartilage morphology (HP:0002763)2.22073347
80Prolonged bleeding time (HP:0003010)2.21816406
81Amyloidosis (HP:0011034)2.20574198
82Abnormal gallbladder physiology (HP:0012438)2.20269175
83Cholecystitis (HP:0001082)2.20269175
84Right ventricular cardiomyopathy (HP:0011663)2.16779906
85Esophageal varix (HP:0002040)2.15389956
86Irritability (HP:0000737)2.14911933
87Rickets (HP:0002748)2.14368838
88Hypophosphatemic rickets (HP:0004912)2.13679763
89Bifid scrotum (HP:0000048)2.13584175
90Generalized aminoaciduria (HP:0002909)2.11522163
91Protrusio acetabuli (HP:0003179)2.11288893
92Neonatal onset (HP:0003623)2.07715485
93Vomiting (HP:0002013)2.05311706
94Enlarged kidneys (HP:0000105)2.03489060
95Joint swelling (HP:0001386)1.98199440
96Late onset (HP:0003584)1.98113271
97Hyperglycemia (HP:0003074)1.97949789
98Broad metatarsal (HP:0001783)1.95362844
99Abnormal tarsal ossification (HP:0008369)1.92967249
100Turricephaly (HP:0000262)1.92618079
101Pulmonary embolism (HP:0002204)1.91545182
102Hemorrhage of the eye (HP:0011885)1.91230660
103Myoglobinuria (HP:0002913)1.89827936
104Abnormality of the gallbladder (HP:0005264)1.88321429
105Impaired platelet aggregation (HP:0003540)1.87921713
106Abnormal platelet function (HP:0011869)1.87921713
107Nephritis (HP:0000123)1.87901790
108Back pain (HP:0003418)1.87700358
109Abnormality of the Achilles tendon (HP:0005109)1.86169354
110Pancreatitis (HP:0001733)1.79752993
111Retinal atrophy (HP:0001105)1.79359700
112Abnormal enzyme/coenzyme activity (HP:0012379)1.78226609
113Sensorimotor neuropathy (HP:0007141)1.78074207
114Hyperuricemia (HP:0002149)1.76722313
115Increased purine levels (HP:0004368)1.76722313
116Submucous cleft hard palate (HP:0000176)1.75861530
117Brushfield spots (HP:0001088)1.74832191
118Abnormal delivery (HP:0001787)1.74091768
119Premature rupture of membranes (HP:0001788)1.74086413
120Alkalosis (HP:0001948)1.73268118
121Glycosuria (HP:0003076)1.72524603
122Abnormality of urine glucose concentration (HP:0011016)1.72524603
123Abnormality of transition element cation homeostasis (HP:0011030)1.71380863
124Acanthocytosis (HP:0001927)1.70870569
125Abnormality of carpal bone ossification (HP:0006257)1.69626916
126Opisthotonus (HP:0002179)1.68324712
127Abnormality of vitamin metabolism (HP:0100508)1.66796840
128Fair hair (HP:0002286)1.64853760
129Increased serum ferritin (HP:0003281)1.64153819
130Pigmentary retinal degeneration (HP:0001146)1.60406431
131Abnormality of the nasal septum (HP:0000419)1.60261256
132Abnormality of iron homeostasis (HP:0011031)1.57119802
133Mucopolysacchariduria (HP:0008155)1.52200284
134Urinary glycosaminoglycan excretion (HP:0003541)1.52200284
135Scanning speech (HP:0002168)1.49300650
136Hyperphosphaturia (HP:0003109)1.46221111
137Neonatal death (HP:0003811)1.45803288

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.06939242
2SIK14.17991976
3ERN13.36918789
4FGFR43.12771435
5TRIB33.08826468
6LATS12.88487293
7NTRK32.73187497
8INSRR2.25041842
9FGFR32.10075888
10ERBB42.10006197
11PKN22.06599721
12MAPKAPK32.01857282
13PINK11.85439829
14MET1.79128764
15STK38L1.78406214
16MST1R1.75513508
17DDR21.65723565
18RIPK11.61543273
19MAP2K41.58677210
20EPHB11.52160550
21PDGFRA1.49385521
22FGFR21.46816747
23EPHA21.46235623
24PTK61.45245843
25LATS21.44165644
26PDK31.35428579
27PDK41.35428579
28GRK11.34340225
29TTN1.33844605
30EIF2AK11.33623233
31IRAK31.30222644
32CAMK1D1.27251155
33MAPK111.21042805
34FLT31.16562599
35TAOK31.16275716
36ADRBK21.15297329
37MAP3K21.13740050
38ICK1.13504385
39PHKG21.12279078
40PHKG11.12279078
41PRKCG1.11929742
42TIE11.10496984
43MAP3K71.09807275
44PDK11.08797643
45LMTK21.03705641
46PRKAA21.03702387
47TGFBR21.02935424
48PDK21.02709592
49FER1.01493966
50EPHB21.00088167
51PIK3CG0.98574895
52DAPK20.98303700
53ABL20.94898686
54NEK90.94346420
55PAK30.92808021
56EPHA30.90895569
57GSK3A0.90733845
58PTK20.90178126
59MUSK0.89812486
60AKT30.88389211
61WNK40.87972217
62EEF2K0.87604972
63CAMKK20.84771420
64MAPK150.84668791
65MAP3K30.84658543
66ERBB20.82867115
67CAMK2G0.78791343
68MAPKAPK50.78701891
69CAMK2B0.78105490
70CAMK1G0.77823918
71MAPK120.77693806
72MYLK0.76789661
73KSR20.76597796
74PRKAA10.75834507
75GRK50.75479290
76MTOR0.73971169
77PRKD10.73900454
78PKN10.72093247
79NTRK20.71974481
80OBSCN0.71120675
81DAPK30.69946360
82PRKACG0.69172251
83SGK10.68321545
84SGK30.66454453
85MAPK70.66302126
86SGK2230.65944077
87SGK4940.65944077
88BMX0.65836063
89GRK60.65496224
90STK390.64695336
91STK380.64347560
92JAK20.64256050
93CAMKK10.63167696
94CDK120.62086188
95CSNK1D0.61858187
96ACVR1B0.61082309
97MAP2K60.60381285
98MAP3K10.59886584
99MAP2K20.57455705
100PRKG10.56140404
101PRKCZ0.55350279
102CDK60.55036535
103NTRK10.54969558
104WNK30.54751608
105KDR0.54118034
106PRKACA0.53539538
107TYRO30.53200393
108ILK0.52519270
109MAP2K10.51945496
110CSK0.51586485
111RPS6KB10.50226070
112JAK10.49867127
113TAOK20.49834580
114MAPK40.49729964
115DYRK1B0.48999835
116CSF1R0.48918601
117BMPR1B0.48820058
118RPS6KA30.48787105
119PDPK10.48623873
120FRK0.48612834
121FGFR10.47690688
122EPHA40.46834045
123OXSR10.46008275
124MAP2K30.45181314
125RET0.44945115
126PDGFRB0.44875992
127PIK3CA0.44696100
128CAMK40.44423209
129STK30.44187014
130NEK10.44097194
131PRKCA0.43542585
132SGK20.41132211
133WNK10.39957816
134MAP3K60.36445088
135TYK20.33800415
136PRKACB0.32959964
137IGF1R0.31590511
138CAMK2D0.30844005

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.01724100
2Nitrogen metabolism_Homo sapiens_hsa009103.68479802
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.11082557
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.02707068
5Arginine biosynthesis_Homo sapiens_hsa002202.89893491
6Fatty acid degradation_Homo sapiens_hsa000712.73218215
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.73048132
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.66927138
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.64425427
10Tryptophan metabolism_Homo sapiens_hsa003802.56678436
11Complement and coagulation cascades_Homo sapiens_hsa046102.47811295
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.40087077
13Propanoate metabolism_Homo sapiens_hsa006402.32028845
14Butanoate metabolism_Homo sapiens_hsa006502.26952933
15Fatty acid metabolism_Homo sapiens_hsa012122.15597325
16PPAR signaling pathway_Homo sapiens_hsa033202.04018137
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99517836
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.98023509
19Peroxisome_Homo sapiens_hsa041461.97180141
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.89739539
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88341602
22Chemical carcinogenesis_Homo sapiens_hsa052041.85132785
23Histidine metabolism_Homo sapiens_hsa003401.80526800
24beta-Alanine metabolism_Homo sapiens_hsa004101.76866218
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74795519
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74455108
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.69481561
28Fatty acid elongation_Homo sapiens_hsa000621.63671949
29Retinol metabolism_Homo sapiens_hsa008301.60681851
30Caffeine metabolism_Homo sapiens_hsa002321.54913684
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53129291
32Pyruvate metabolism_Homo sapiens_hsa006201.49329642
33Bile secretion_Homo sapiens_hsa049761.47651160
34Phenylalanine metabolism_Homo sapiens_hsa003601.45545422
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.42553773
36Staphylococcus aureus infection_Homo sapiens_hsa051501.38044016
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36216444
38Selenocompound metabolism_Homo sapiens_hsa004501.32959404
39Carbon metabolism_Homo sapiens_hsa012001.31979221
40Sulfur metabolism_Homo sapiens_hsa009201.31351613
41Tyrosine metabolism_Homo sapiens_hsa003501.30498989
42Starch and sucrose metabolism_Homo sapiens_hsa005001.26224665
43Biosynthesis of amino acids_Homo sapiens_hsa012301.22029100
44Steroid biosynthesis_Homo sapiens_hsa001001.19146631
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.16994794
46Fat digestion and absorption_Homo sapiens_hsa049751.15115282
47ABC transporters_Homo sapiens_hsa020101.13416127
48Arginine and proline metabolism_Homo sapiens_hsa003301.08286029
49Folate biosynthesis_Homo sapiens_hsa007901.07680961
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04967519
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04455455
52Vitamin B6 metabolism_Homo sapiens_hsa007501.01907818
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99836663
54Fatty acid biosynthesis_Homo sapiens_hsa000610.93208222
55Lysine degradation_Homo sapiens_hsa003100.92738204
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.91997247
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.81385662
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77274060
59Vitamin digestion and absorption_Homo sapiens_hsa049770.76996925
60Glycerolipid metabolism_Homo sapiens_hsa005610.75179738
61Sulfur relay system_Homo sapiens_hsa041220.75053904
62Glutathione metabolism_Homo sapiens_hsa004800.73284014
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69765456
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66763772
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.61964240
66Pentose phosphate pathway_Homo sapiens_hsa000300.52547448
67One carbon pool by folate_Homo sapiens_hsa006700.45866285
68Metabolic pathways_Homo sapiens_hsa011000.44192563
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40194536
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37636001
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.37353061
72Insulin resistance_Homo sapiens_hsa049310.36028339
73Prion diseases_Homo sapiens_hsa050200.34387962
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32367412
75Fructose and mannose metabolism_Homo sapiens_hsa000510.32324291
76Linoleic acid metabolism_Homo sapiens_hsa005910.32011132
77Galactose metabolism_Homo sapiens_hsa000520.30358954
78ECM-receptor interaction_Homo sapiens_hsa045120.27689954
79Other glycan degradation_Homo sapiens_hsa005110.25711624
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.23594742
81Sphingolipid metabolism_Homo sapiens_hsa006000.23113632
82Mineral absorption_Homo sapiens_hsa049780.19834238
83AMPK signaling pathway_Homo sapiens_hsa041520.19476873
84Glucagon signaling pathway_Homo sapiens_hsa049220.19346097
85Renin-angiotensin system_Homo sapiens_hsa046140.17705520
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.17365221
87Protein digestion and absorption_Homo sapiens_hsa049740.15811224
88Pertussis_Homo sapiens_hsa051330.14912606
89Serotonergic synapse_Homo sapiens_hsa047260.14615671
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.07830532
91Platelet activation_Homo sapiens_hsa046110.06811989
92Ovarian steroidogenesis_Homo sapiens_hsa049130.03953785
93Insulin signaling pathway_Homo sapiens_hsa049100.03231806
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.03219048
95GABAergic synapse_Homo sapiens_hsa047270.03033360
96Amoebiasis_Homo sapiens_hsa051460.02814868
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.1192568
98Ether lipid metabolism_Homo sapiens_hsa00565-0.1139269
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.1069347
100Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0969787
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410-0.0964509
102Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0915850
103Dilated cardiomyopathy_Homo sapiens_hsa05414-0.0905090
104Focal adhesion_Homo sapiens_hsa04510-0.0898507
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0866538
106Bladder cancer_Homo sapiens_hsa05219-0.0651082
107Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0642130
108Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0636797
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0636539
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.0475417
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412-0.0432461
112Glutamatergic synapse_Homo sapiens_hsa04724-0.0293010
113N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0205284
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0188480
115Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0091590
116Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0091062
117Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0035229

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