PCSK7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes and plays a role in the regulation of iron metabolism. A t(11;14)(q23;q32) chromosome translocation associated with B-cell lymphoma occurs between this gene and its inverted counterpart. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.36994202
2L-phenylalanine catabolic process (GO:0006559)4.36994202
3triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.28634899
4activated T cell proliferation (GO:0050798)4.27785432
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.24203422
6L-phenylalanine metabolic process (GO:0006558)4.24203422
7alpha-linolenic acid metabolic process (GO:0036109)4.23670018
8aromatic amino acid family catabolic process (GO:0009074)4.02686918
9fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.98144598
10negative T cell selection (GO:0043383)3.93912223
11kynurenine metabolic process (GO:0070189)3.89735670
12sulfur amino acid catabolic process (GO:0000098)3.88840429
13negative thymic T cell selection (GO:0045060)3.86906883
14positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.80845405
15lysine catabolic process (GO:0006554)3.77055022
16lysine metabolic process (GO:0006553)3.77055022
17complement activation, alternative pathway (GO:0006957)3.76717097
18protein carboxylation (GO:0018214)3.75434070
19peptidyl-glutamic acid carboxylation (GO:0017187)3.75434070
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.75303651
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.75303651
22indole-containing compound catabolic process (GO:0042436)3.73197189
23indolalkylamine catabolic process (GO:0046218)3.73197189
24tryptophan catabolic process (GO:0006569)3.73197189
25negative regulation of fibrinolysis (GO:0051918)3.72998254
26glyoxylate metabolic process (GO:0046487)3.67547509
27urea cycle (GO:0000050)3.67525255
28urea metabolic process (GO:0019627)3.67525255
29bile acid biosynthetic process (GO:0006699)3.67103014
30negative regulation of sterol transport (GO:0032372)3.65380953
31negative regulation of cholesterol transport (GO:0032375)3.65380953
32regulation of triglyceride catabolic process (GO:0010896)3.60164110
33tryptophan metabolic process (GO:0006568)3.59458707
34high-density lipoprotein particle remodeling (GO:0034375)3.58673437
35amino-acid betaine metabolic process (GO:0006577)3.58653728
36positive regulation of CREB transcription factor activity (GO:0032793)3.58181583
37interferon-gamma production (GO:0032609)3.57653809
38homocysteine metabolic process (GO:0050667)3.56629618
39negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.56052897
40negative regulation of cell killing (GO:0031342)3.56052897
41phospholipid homeostasis (GO:0055091)3.55408452
42regulation of cholesterol homeostasis (GO:2000188)3.54653573
43regulation of protein activation cascade (GO:2000257)3.51922109
44nitrogen cycle metabolic process (GO:0071941)3.44463813
45plasma lipoprotein particle clearance (GO:0034381)3.41460058
46positive T cell selection (GO:0043368)3.39491297
47regulation of complement activation (GO:0030449)3.35444837
48phospholipid efflux (GO:0033700)3.34108068
49cellular response to exogenous dsRNA (GO:0071360)3.32825054
50cysteine metabolic process (GO:0006534)3.32681592
51antigen processing and presentation of endogenous antigen (GO:0019883)3.31045392
52pericardium development (GO:0060039)3.26128158
53negative regulation of translation, ncRNA-mediated (GO:0040033)3.20306741
54regulation of translation, ncRNA-mediated (GO:0045974)3.20306741
55negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.20306741
56response to interleukin-15 (GO:0070672)3.20022952
57regulation of fatty acid beta-oxidation (GO:0031998)3.19505347
58L-fucose metabolic process (GO:0042354)3.18424908
59L-fucose catabolic process (GO:0042355)3.18424908
60fucose catabolic process (GO:0019317)3.18424908
61negative regulation of T cell mediated immunity (GO:0002710)3.17329232
62regulation of fibrinolysis (GO:0051917)3.17256181
63bile acid metabolic process (GO:0008206)3.16935413
64reverse cholesterol transport (GO:0043691)3.16248337
65cellular response to interleukin-15 (GO:0071350)3.13076772
66T cell selection (GO:0045058)3.12302463
67positive thymic T cell selection (GO:0045059)3.12203173
68protein-lipid complex remodeling (GO:0034368)3.11336644
69macromolecular complex remodeling (GO:0034367)3.11336644
70plasma lipoprotein particle remodeling (GO:0034369)3.11336644
71regulation of gamma-delta T cell differentiation (GO:0045586)3.11220822
72regulation of cholesterol esterification (GO:0010872)3.09217621
73positive regulation of gamma-delta T cell activation (GO:0046645)3.07165817
74thymic T cell selection (GO:0045061)3.06179162
75positive regulation of lipid catabolic process (GO:0050996)3.06040295
762-oxoglutarate metabolic process (GO:0006103)3.05097930
77tolerance induction (GO:0002507)3.04953416
78positive regulation of fatty acid beta-oxidation (GO:0032000)3.03846858
79protein-lipid complex assembly (GO:0065005)3.02021292
80plasma lipoprotein particle assembly (GO:0034377)3.01594440
81regulation of interferon-beta biosynthetic process (GO:0045357)2.98699811
82regulation of podosome assembly (GO:0071801)2.98362436
83low-density lipoprotein particle clearance (GO:0034383)2.97701816
84positive regulation of histone deacetylation (GO:0031065)2.97541605
85carnitine metabolic process (GO:0009437)2.95332219
86positive regulation of T cell mediated cytotoxicity (GO:0001916)2.93219834
87serine family amino acid catabolic process (GO:0009071)2.93176723
88mannose metabolic process (GO:0006013)2.92248333
89regulation of gamma-delta T cell activation (GO:0046643)2.89132499
90regulation of MHC class I biosynthetic process (GO:0045343)2.88336212
91regulation of cholesterol storage (GO:0010885)2.86758996
92regulation of B cell receptor signaling pathway (GO:0050855)2.86729619
93regulation of T cell mediated cytotoxicity (GO:0001914)2.85084282
94behavioral response to nicotine (GO:0035095)2.84716451
95cholesterol efflux (GO:0033344)2.84031742
96positive regulation of lipoprotein lipase activity (GO:0051006)2.83251323
97positive regulation of triglyceride lipase activity (GO:0061365)2.83251323
98aromatic amino acid family metabolic process (GO:0009072)2.82972372
99triglyceride homeostasis (GO:0070328)2.82741860
100acylglycerol homeostasis (GO:0055090)2.82741860
101cholesterol homeostasis (GO:0042632)2.82448965
102positive regulation of triglyceride metabolic process (GO:0090208)2.82101500
103regulation of hippo signaling (GO:0035330)2.82081643
104antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.81800682
105drug catabolic process (GO:0042737)2.80757002
106tyrosine metabolic process (GO:0006570)2.79966829
107positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.78694746
108sterol homeostasis (GO:0055092)2.77672340
109positive regulation of fatty acid oxidation (GO:0046321)2.77226041
110bile acid and bile salt transport (GO:0015721)2.76791535
111fatty acid beta-oxidation (GO:0006635)2.76531518
112regulation of interleukin-12 biosynthetic process (GO:0045075)2.73439454
113apoptotic cell clearance (GO:0043277)2.71896134
114dicarboxylic acid biosynthetic process (GO:0043650)2.71686419
115histone H3-K4 trimethylation (GO:0080182)2.70482913
116negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.70237652
117ethanol oxidation (GO:0006069)2.69650600
118lipoprotein metabolic process (GO:0042157)2.69335705
119positive regulation of defense response to virus by host (GO:0002230)2.68857399
120fatty acid oxidation (GO:0019395)2.67811033
121valine metabolic process (GO:0006573)2.66995618
122leukocyte aggregation (GO:0070486)2.66917202
123short-chain fatty acid metabolic process (GO:0046459)2.66344774
124intestinal cholesterol absorption (GO:0030299)2.65490929
125fibrinolysis (GO:0042730)2.64906070
126cellular modified amino acid catabolic process (GO:0042219)2.63899954
127acetyl-CoA metabolic process (GO:0006084)2.63498347
128complement activation, classical pathway (GO:0006958)2.62957009
129growth hormone receptor signaling pathway (GO:0060396)2.62682321
130complement activation (GO:0006956)2.62378685
131regulation of fatty acid oxidation (GO:0046320)2.62086329
132tricarboxylic acid metabolic process (GO:0072350)2.61985642
133benzene-containing compound metabolic process (GO:0042537)2.61791692
134cellular glucuronidation (GO:0052695)2.60982438
135lipid oxidation (GO:0034440)2.60868347
136alpha-amino acid catabolic process (GO:1901606)2.60476621
137negative regulation of lymphocyte mediated immunity (GO:0002707)2.60065816
138negative regulation of lipid transport (GO:0032369)2.59768965
139urate metabolic process (GO:0046415)2.59364082
140positive regulation of protein deacetylation (GO:0090312)2.58832802
141positive regulation of natural killer cell differentiation (GO:0032825)2.56121657
142positive regulation of developmental pigmentation (GO:0048087)2.51628562
143striated muscle atrophy (GO:0014891)2.51185962
144interkinetic nuclear migration (GO:0022027)2.50114012
145positive regulation of granulocyte differentiation (GO:0030854)2.47360443
146B cell receptor signaling pathway (GO:0050853)2.47152120
147antigen processing and presentation via MHC class Ib (GO:0002475)2.46973517
148regulation of histone deacetylation (GO:0031063)2.46528802
149monoubiquitinated protein deubiquitination (GO:0035520)2.46109466
150regulation of regulatory T cell differentiation (GO:0045589)2.45944322
151regulation of alpha-beta T cell proliferation (GO:0046640)2.45774416
152protein K48-linked deubiquitination (GO:0071108)2.37562480
153regulation of pigment cell differentiation (GO:0050932)2.36908118
154cellular extravasation (GO:0045123)2.35918890
155positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.33867650
156regulation of gene silencing by RNA (GO:0060966)2.33824330
157regulation of posttranscriptional gene silencing (GO:0060147)2.33824330
158regulation of gene silencing by miRNA (GO:0060964)2.33824330
159T cell migration (GO:0072678)2.32220625
160cellular response to ethanol (GO:0071361)2.31612212
161negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.30566398
162negative regulation of cAMP-mediated signaling (GO:0043951)2.29741928
163lipid translocation (GO:0034204)2.29247957
164phospholipid translocation (GO:0045332)2.29247957
165regulation of leukocyte mediated cytotoxicity (GO:0001910)2.27411337
166urinary tract smooth muscle contraction (GO:0014848)2.27406473
167negative regulation of interleukin-6 production (GO:0032715)2.27292193
168negative regulation of myotube differentiation (GO:0010832)2.26693776
169regulation of establishment of cell polarity (GO:2000114)2.26478951
170positive regulation of calcium-mediated signaling (GO:0050850)2.26047544
171negative regulation of leukocyte chemotaxis (GO:0002689)2.25730163
172establishment of protein localization to Golgi (GO:0072600)2.25247582
173macroautophagy (GO:0016236)2.21519728
174endocardial cushion development (GO:0003197)2.21130697
175cardiovascular system development (GO:0072358)2.20801382
176regulation of establishment or maintenance of cell polarity (GO:0032878)2.20515438
177positive regulation of antigen processing and presentation (GO:0002579)2.18152332
178positive regulation of cell killing (GO:0031343)2.13804057
179regulation of dendritic cell antigen processing and presentation (GO:0002604)2.13140831
180endosome to melanosome transport (GO:0035646)2.13021382
181endosome to pigment granule transport (GO:0043485)2.13021382
182negative regulation of leukocyte mediated immunity (GO:0002704)2.12763011
183positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.11762108
184regulation of cell killing (GO:0031341)2.11388275
185phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.11382265
186regulation of antigen processing and presentation (GO:0002577)2.10409370
187response to type I interferon (GO:0034340)2.10081742

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.46327576
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.72981376
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.36062864
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.88466607
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.76255561
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.35302985
7EGR1_23403033_ChIP-Seq_LIVER_Mouse2.89393789
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.87414535
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.52286234
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.48920387
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.48872803
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.35596163
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.30891892
14DROSHA_22980978_ChIP-Seq_HELA_Human2.29699832
15CLOCK_20551151_ChIP-Seq_293T_Human2.26686043
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.26252887
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.24989010
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.22757315
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.17771350
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.10797050
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.06006159
22IRF8_27001747_Chip-Seq_BMDM_Mouse2.02265749
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95904487
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93442592
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92753661
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.84141037
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.83806081
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.82591484
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.81653002
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79983712
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.78999392
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.74494312
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.72504447
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.72125140
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.72091917
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.71867345
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.70441675
38RUNX_20019798_ChIP-Seq_JUKART_Human1.69153597
39MAF_26560356_Chip-Seq_TH1_Human1.66489159
40LXR_22292898_ChIP-Seq_THP-1_Human1.65326257
41ZNF274_21170338_ChIP-Seq_K562_Hela1.59904475
42MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.59896766
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.58799460
44VDR_21846776_ChIP-Seq_THP-1_Human1.58442662
45TP53_16413492_ChIP-PET_HCT116_Human1.57136866
46GATA1_22025678_ChIP-Seq_K562_Human1.54774030
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.54502156
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50203521
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.48703849
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.47841272
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.46604717
52MYC_22102868_ChIP-Seq_BL_Human1.46017134
53EZH2_22144423_ChIP-Seq_EOC_Human1.44954977
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42750339
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.41421469
56KDM2B_26808549_Chip-Seq_DND41_Human1.38247421
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38061390
58UTX_26944678_Chip-Seq_JUKART_Human1.37907366
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.37168891
60TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.36490661
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34435790
62STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.33649880
63TCF7_22412390_ChIP-Seq_EML_Mouse1.32688209
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32460427
65SPI1_23127762_ChIP-Seq_K562_Human1.31777488
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31075627
67FOXO3_23340844_ChIP-Seq_DLD1_Human1.29164128
68VDR_24763502_ChIP-Seq_THP-1_Human1.28496721
69SOX2_27498859_Chip-Seq_STOMACH_Mouse1.27367684
70FOXA2_19822575_ChIP-Seq_HepG2_Human1.26919637
71KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24936984
72TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.24702680
73* GATA1_19941826_ChIP-Seq_K562_Human1.24655425
74RACK7_27058665_Chip-Seq_MCF-7_Human1.24456540
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23620117
76CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23128088
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23113326
78* MYB_26560356_Chip-Seq_TH2_Human1.19765956
79VDR_22108803_ChIP-Seq_LS180_Human1.19308384
80AHR_22903824_ChIP-Seq_MCF-7_Human1.19298375
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15676639
82AR_21572438_ChIP-Seq_LNCaP_Human1.15648102
83FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15456295
84STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15404108
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.13277415
86TRIM28_21343339_ChIP-Seq_HEK293_Human1.13030842
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12969575
88* GATA2_19941826_ChIP-Seq_K562_Human1.12404024
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11403257
90ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10954856
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10337076
92* MYB_26560356_Chip-Seq_TH1_Human1.10261404
93HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09472742
94ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09167867
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07841021
96KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07511645
97ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06003198
98EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05946867
99RUNX1_22412390_ChIP-Seq_EML_Mouse1.04978315
100GATA3_26560356_Chip-Seq_TH2_Human1.04803198
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.04610870
102GBX2_23144817_ChIP-Seq_PC3_Human1.03841840
103ESR1_21235772_ChIP-Seq_MCF-7_Human1.03740391
104MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03675466
105TBX20_22080862_ChIP-Seq_HEART_Mouse1.02285468
106TBX20_22328084_ChIP-Seq_HEART_Mouse1.02285468
107BCAT_22108803_ChIP-Seq_LS180_Human1.02041793
108GATA4_25053715_ChIP-Seq_YYC3_Human1.01727875
109ZNF263_19887448_ChIP-Seq_K562_Human1.01270456
110GATA1_19941827_ChIP-Seq_MEL_Mouse1.00309278
111SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99934256
112GATA2_21666600_ChIP-Seq_HMVEC_Human0.99004491
113* MAF_26560356_Chip-Seq_TH2_Human0.98519159
114PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96330350
115VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95801812
116RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95408629
117GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94899325
118CDX2_20551321_ChIP-Seq_CACO-2_Human0.94838372
119SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94571723
120PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94496100
121PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94403476
122GATA3_27048872_Chip-Seq_THYMUS_Human0.94367164
123GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92714441
124ESR1_20079471_ChIP-ChIP_T-47D_Human0.92493697
125GATA6_25053715_ChIP-Seq_YYC3_Human0.92044250
126PRDM14_20953172_ChIP-Seq_ESCs_Human0.91401615
127SCL_19346495_ChIP-Seq_HPC-7_Human0.90510304
128EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90396913
129STAT3_23295773_ChIP-Seq_U87_Human0.90183053
130FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90116533
131RXR_22108803_ChIP-Seq_LS180_Human0.87925654
132PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.87306947
133PU_27001747_Chip-Seq_BMDM_Mouse0.87023327
134ATF3_27146783_Chip-Seq_COLON_Human0.86577251
135HNF4A_19822575_ChIP-Seq_HepG2_Human0.86574627
136P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86356665
137TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86005896
138ER_23166858_ChIP-Seq_MCF-7_Human0.85981990
139FLI1_27457419_Chip-Seq_LIVER_Mouse0.85863350
140CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85733413
141JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85355457
142POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85236180
143TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85236180
144SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85162395
145ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85073506
146EZH2_27294783_Chip-Seq_ESCs_Mouse0.84602455
147VDR_24787735_ChIP-Seq_THP-1_Human0.84263123
148JARID2_20075857_ChIP-Seq_MESCs_Mouse0.84004688
149* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.83731568
150GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83306639
151RNF2_27304074_Chip-Seq_ESCs_Mouse0.82979637
152SMRT_27268052_Chip-Seq_Bcells_Human0.82687473
153PCGF2_27294783_Chip-Seq_ESCs_Mouse0.81337030
154TCF4_23295773_ChIP-Seq_U87_Human0.80338174
155KDM2B_26808549_Chip-Seq_REH_Human0.79979629
156SUZ12_27294783_Chip-Seq_ESCs_Mouse0.79929303
157PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79681998
158WT1_25993318_ChIP-Seq_PODOCYTE_Human0.79434286
159ERA_21632823_ChIP-Seq_H3396_Human0.79302253
160GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78814046
161FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78698709
162AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78610978
163NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.78522621

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.18015574
2MP0002139_abnormal_hepatobiliary_system4.36993909
3MP0005365_abnormal_bile_salt3.69678476
4MP0005085_abnormal_gallbladder_physiolo3.57549945
5MP0009840_abnormal_foam_cell2.88268404
6MP0003705_abnormal_hypodermis_morpholog2.68629588
7MP0003300_gastrointestinal_ulcer2.64992716
8MP0003252_abnormal_bile_duct2.57697061
9MP0008875_abnormal_xenobiotic_pharmacok2.49518539
10MP0000569_abnormal_digit_pigmentation2.47895135
11MP0001958_emphysema2.39577289
12MP0003279_aneurysm2.37258364
13MP0010329_abnormal_lipoprotein_level2.35066886
14MP0003191_abnormal_cellular_cholesterol2.23299416
15MP0004043_abnormal_pH_regulation2.16052368
16MP0001666_abnormal_nutrient_absorption2.01969719
17MP0005083_abnormal_biliary_tract2.01425941
18MP0005503_abnormal_tendon_morphology1.99666619
19MP0003436_decreased_susceptibility_to1.98167729
20MP0008961_abnormal_basal_metabolism1.96280538
21MP0003646_muscle_fatigue1.93410269
22MP0003303_peritoneal_inflammation1.91876620
23MP0009384_cardiac_valve_regurgitation1.87667120
24MP0005310_abnormal_salivary_gland1.85649547
25MP0003195_calcinosis1.84827158
26MP0000609_abnormal_liver_physiology1.80416722
27MP0003806_abnormal_nucleotide_metabolis1.77918885
28MP0001348_abnormal_lacrimal_gland1.77682427
29MP0005332_abnormal_amino_acid1.77410813
30MP0005058_abnormal_lysosome_morphology1.74368521
31MP0001986_abnormal_taste_sensitivity1.71822580
32MP0001835_abnormal_antigen_presentation1.62708657
33MP0002166_altered_tumor_susceptibility1.60927420
34MP0000685_abnormal_immune_system1.53356884
35MP0005464_abnormal_platelet_physiology1.52686072
36MP0001790_abnormal_immune_system1.51151467
37MP0005387_immune_system_phenotype1.51151467
38MP0004947_skin_inflammation1.51123202
39MP0004381_abnormal_hair_follicle1.49635089
40MP0001501_abnormal_sleep_pattern1.46905507
41MP0010386_abnormal_urinary_bladder1.43674281
42MP0002118_abnormal_lipid_homeostasis1.43656108
43MP0002419_abnormal_innate_immunity1.41607913
44MP0009643_abnormal_urine_homeostasis1.40561144
45MP0005319_abnormal_enzyme/_coenzyme1.39296137
46MP0003724_increased_susceptibility_to1.38001454
47MP0000230_abnormal_systemic_arterial1.37992045
48MP0002138_abnormal_hepatobiliary_system1.34705461
49MP0001800_abnormal_humoral_immune1.30909228
50MP0005174_abnormal_tail_pigmentation1.30322405
51MP0005025_abnormal_response_to1.30253903
52MP0000538_abnormal_urinary_bladder1.29725855
53MP0004130_abnormal_muscle_cell1.29367367
54MP0008469_abnormal_protein_level1.28811312
55MP0003172_abnormal_lysosome_physiology1.27634115
56MP0010155_abnormal_intestine_physiology1.27465199
57MP0000604_amyloidosis1.24856513
58MP0004019_abnormal_vitamin_homeostasis1.23423798
59MP0006082_CNS_inflammation1.21865733
60MP0005670_abnormal_white_adipose1.21790916
61MP0001873_stomach_inflammation1.21681598
62MP0005595_abnormal_vascular_smooth1.21539538
63MP0002452_abnormal_antigen_presenting1.21385317
64MP0004142_abnormal_muscle_tone1.21358037
65MP0003566_abnormal_cell_adhesion1.21133283
66MP0005000_abnormal_immune_tolerance1.19950472
67MP0009278_abnormal_bone_marrow1.19818171
68MP0010234_abnormal_vibrissa_follicle1.19373702
69MP0005584_abnormal_enzyme/coenzyme_acti1.19168428
70MP0008438_abnormal_cutaneous_collagen1.18585541
71MP0000767_abnormal_smooth_muscle1.18576574
72MP0009785_altered_susceptibility_to1.16368509
73MP0009333_abnormal_splenocyte_physiolog1.13773181
74MP0002723_abnormal_immune_serum1.13127898
75MP0001845_abnormal_inflammatory_respons1.12942234
76MP0000598_abnormal_liver_morphology1.11866700
77MP0000470_abnormal_stomach_morphology1.11495456
78MP0005023_abnormal_wound_healing1.11298798
79MP0005381_digestive/alimentary_phenotyp1.10775436
80MP0002928_abnormal_bile_duct1.10447880
81MP0002876_abnormal_thyroid_physiology1.09849463
82MP0002168_other_aberrant_phenotype1.08992101
83MP0001533_abnormal_skeleton_physiology1.08140238
84MP0009764_decreased_sensitivity_to1.07237459
85MP0001851_eye_inflammation1.06989721
86MP0001664_abnormal_digestion1.06856408
87MP0005666_abnormal_adipose_tissue1.05820096
88MP0003075_altered_response_to1.05733384
89MP0004185_abnormal_adipocyte_glucose1.05586258
90MP0005451_abnormal_body_composition1.05129076
91MP0001764_abnormal_homeostasis1.03705888
92MP0002396_abnormal_hematopoietic_system1.03433707
93MP0000703_abnormal_thymus_morphology1.03056262
94MP0001819_abnormal_immune_cell1.01750827
95MP0009763_increased_sensitivity_to1.01588772
96MP0002420_abnormal_adaptive_immunity1.01468516
97MP0005275_abnormal_skin_tensile1.00731219
98MP0005671_abnormal_response_to0.98433027
99MP0000427_abnormal_hair_cycle0.97700399
100MP0002006_tumorigenesis0.95935253
101MP0003283_abnormal_digestive_organ0.94884222
102MP0002998_abnormal_bone_remodeling0.94636282
103MP0002254_reproductive_system_inflammat0.94517610
104MP0001756_abnormal_urination0.94218555
105MP0004883_abnormal_blood_vessel0.94067207
106MP0002136_abnormal_kidney_physiology0.94002792
107MP0002933_joint_inflammation0.92544311
108MP0008872_abnormal_physiological_respon0.92396065
109MP0003656_abnormal_erythrocyte_physiolo0.91215690
110MP0003763_abnormal_thymus_physiology0.90561045
111MP0010352_gastrointestinal_tract_polyps0.90008783
112MP0010368_abnormal_lymphatic_system0.88376993
113MP0002429_abnormal_blood_cell0.88336081
114MP0000465_gastrointestinal_hemorrhage0.88202049
115MP0002148_abnormal_hypersensitivity_rea0.87528906
116MP0003866_abnormal_defecation0.87234986
117MP0003045_fibrosis0.87197678
118MP0000015_abnormal_ear_pigmentation0.85881274
119MP0001765_abnormal_ion_homeostasis0.85727080
120MP0004510_myositis0.85456764
121MP0005166_decreased_susceptibility_to0.85435202
122MP0003453_abnormal_keratinocyte_physiol0.84309009
123MP0005390_skeleton_phenotype0.83905186
124MP0003950_abnormal_plasma_membrane0.82594769
125MP0003091_abnormal_cell_migration0.82533256
126MP0002722_abnormal_immune_system0.82479308
127MP0009115_abnormal_fat_cell0.81317654
128MP0000716_abnormal_immune_system0.81312533
129MP0005636_abnormal_mineral_homeostasis0.80531495
130MP0005448_abnormal_energy_balance0.79716754
131MP0005164_abnormal_response_to0.78952104
132MP0001853_heart_inflammation0.78044072
133MP0001502_abnormal_circadian_rhythm0.77946011
134MP0003828_pulmonary_edema0.77624741
135MP0001881_abnormal_mammary_gland0.77469701
136MP0000249_abnormal_blood_vessel0.76964260
137MP0009642_abnormal_blood_homeostasis0.76594001
138MP0000689_abnormal_spleen_morphology0.76530733
139MP0002405_respiratory_system_inflammati0.76401387
140MP0005551_abnormal_eye_electrophysiolog0.76282889
141MP0000013_abnormal_adipose_tissue0.76078159
142MP0002398_abnormal_bone_marrow0.75796768
143MP0001243_abnormal_dermal_layer0.72958821
144MP0002971_abnormal_brown_adipose0.72738350
145MP0001663_abnormal_digestive_system0.72116334
146MP0003868_abnormal_feces_composition0.71805290
147MP0005167_abnormal_blood-brain_barrier0.71492007
148MP0000343_altered_response_to0.71026355
149MP0002108_abnormal_muscle_morphology0.64340007

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)4.71202241
2Deep venous thrombosis (HP:0002625)4.71105699
3Xanthomatosis (HP:0000991)4.10857287
4Complement deficiency (HP:0004431)3.82125564
5Abnormal delayed hypersensitivity skin test (HP:0002963)3.78012044
6Intrahepatic cholestasis (HP:0001406)3.68565632
7Abnormality of monocarboxylic acid metabolism (HP:0010996)3.63443112
8Clumsiness (HP:0002312)3.53303246
9Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.51716956
10Abnormality of aromatic amino acid family metabolism (HP:0004338)3.44500599
11Neonatal hypoglycemia (HP:0001998)3.36130367
12Protruding tongue (HP:0010808)3.23085676
13Hyperventilation (HP:0002883)3.18904205
14Systemic lupus erythematosus (HP:0002725)3.16351249
15Hypobetalipoproteinemia (HP:0003563)3.15227448
16Myositis (HP:0100614)3.11354757
17Hyperlipoproteinemia (HP:0010980)3.04590489
18Abnormality of the common coagulation pathway (HP:0010990)3.03338941
19Myocardial infarction (HP:0001658)3.03149907
20Decreased circulating renin level (HP:0003351)3.00410330
21Retrobulbar optic neuritis (HP:0100654)3.00010380
22Optic neuritis (HP:0100653)3.00010380
23Congenital stationary night blindness (HP:0007642)2.97579290
24Abnormality of complement system (HP:0005339)2.94860823
25Progressive cerebellar ataxia (HP:0002073)2.93243673
26Orchitis (HP:0100796)2.89415621
27Recurrent fungal infections (HP:0002841)2.87575057
28Elevated erythrocyte sedimentation rate (HP:0003565)2.87254166
29Joint hemorrhage (HP:0005261)2.85853117
30Abnormality of glutamine family amino acid metabolism (HP:0010902)2.85253280
31Chronic mucocutaneous candidiasis (HP:0002728)2.84789633
32Recurrent cutaneous fungal infections (HP:0011370)2.84789633
33Hypoplastic ischia (HP:0003175)2.79255141
34Abnormality of sulfur amino acid metabolism (HP:0004339)2.78719638
35Long foot (HP:0001833)2.76960437
36Prolonged partial thromboplastin time (HP:0003645)2.75315387
37Vacuolated lymphocytes (HP:0001922)2.75100041
38Abnormality of T cell number (HP:0011839)2.72047049
39Recurrent gram-negative bacterial infections (HP:0005420)2.70007679
40Hepatoblastoma (HP:0002884)2.68338521
41Ketosis (HP:0001946)2.67788192
42Hyperammonemia (HP:0001987)2.67568697
43Hypolipoproteinemia (HP:0010981)2.64735006
44Broad metatarsal (HP:0001783)2.64697605
45Aortic dissection (HP:0002647)2.60504215
46Hypoalphalipoproteinemia (HP:0003233)2.58636305
47Panhypogammaglobulinemia (HP:0003139)2.55551746
48Increased neuronal autofluorescent lipopigment (HP:0002074)2.54267690
49T lymphocytopenia (HP:0005403)2.54169770
50Eczematoid dermatitis (HP:0000976)2.50943193
51Neoplasm of the adrenal cortex (HP:0100641)2.49981058
52Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.47210000
53Fat malabsorption (HP:0002630)2.38349520
54Abnormality of fatty-acid metabolism (HP:0004359)2.38223776
55Periodontitis (HP:0000704)2.37899173
56Hypercholesterolemia (HP:0003124)2.37343668
57Stomach cancer (HP:0012126)2.36429521
58Abnormality of the fingertips (HP:0001211)2.36003757
59Esophageal varix (HP:0002040)2.35832299
60Pustule (HP:0200039)2.34227541
61Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.33727232
62Pancreatic cysts (HP:0001737)2.32525220
63Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.31377865
64Hemoptysis (HP:0002105)2.31372988
65Recurrent bronchitis (HP:0002837)2.30183828
66Abnormality of purine metabolism (HP:0004352)2.27984726
67Abnormal glucose tolerance (HP:0001952)2.27930322
68Gingival bleeding (HP:0000225)2.26803313
69Epidermoid cyst (HP:0200040)2.25257019
70Encephalitis (HP:0002383)2.24827791
71Ketoacidosis (HP:0001993)2.24469668
72Abnormality of the ischium (HP:0003174)2.22574326
73Abnormality of the intrinsic pathway (HP:0010989)2.20115355
74Large for gestational age (HP:0001520)2.19074756
75Vascular calcification (HP:0004934)2.19074600
76Impaired platelet aggregation (HP:0003540)2.18903376
77Abnormal platelet function (HP:0011869)2.18903376
78Pulmonary infiltrates (HP:0002113)2.18690063
79Hypoglycemic coma (HP:0001325)2.18381676
80Molar tooth sign on MRI (HP:0002419)2.17085889
81Abnormality of midbrain morphology (HP:0002418)2.17085889
82Stomatitis (HP:0010280)2.15903216
83Abnormality of aspartate family amino acid metabolism (HP:0010899)2.15802165
84Autoimmune thrombocytopenia (HP:0001973)2.15359486
85Abnormal pancreas size (HP:0012094)2.15351845
86Hyperglycinuria (HP:0003108)2.14906453
87Abnormality of serine family amino acid metabolism (HP:0010894)2.14230571
88Abnormality of glycine metabolism (HP:0010895)2.14230571
89Gaze-evoked nystagmus (HP:0000640)2.14069591
90Attenuation of retinal blood vessels (HP:0007843)2.13507181
91Cardiomegaly (HP:0001640)2.13369254
92Mitral stenosis (HP:0001718)2.12913146
93Fair hair (HP:0002286)2.12410347
94Cardiovascular calcification (HP:0011915)2.12319660
95Abnormality of nucleobase metabolism (HP:0010932)2.11816108
96Aortic regurgitation (HP:0001659)2.11324652
97Abnormality of T cells (HP:0002843)2.11063626
98Patellar aplasia (HP:0006443)2.10667384
99Keratoconjunctivitis (HP:0001096)2.10601029
100Diastasis recti (HP:0001540)2.10343311
101Bulbous nose (HP:0000414)2.10102353
102Recurrent bacterial skin infections (HP:0005406)2.09127473
103Axonal loss (HP:0003447)2.06939723
104Gout (HP:0001997)2.06792254
105Spontaneous hematomas (HP:0007420)2.04304350
106Amyloidosis (HP:0011034)2.03824652
107Polycythemia (HP:0001901)2.03457735
108Prolonged QT interval (HP:0001657)2.03274636
109Right ventricular cardiomyopathy (HP:0011663)2.03196146
110Hyperglycinemia (HP:0002154)2.03050212
111Glomerulonephritis (HP:0000099)2.01234000
112Abnormality of iron homeostasis (HP:0011031)2.01052582
113Nephritis (HP:0000123)1.99972374
114Persistence of primary teeth (HP:0006335)1.99885825
115Mucopolysacchariduria (HP:0008155)1.99644579
116Urinary glycosaminoglycan excretion (HP:0003541)1.99644579
117Gastrointestinal infarctions (HP:0005244)1.99564349
118Nonimmune hydrops fetalis (HP:0001790)1.98539711
119Chronic hepatic failure (HP:0100626)1.97212709
120Keratoconjunctivitis sicca (HP:0001097)1.96761532
121Increased mean platelet volume (HP:0011877)1.95297834
122Hemiplegia (HP:0002301)1.95234613
123Aplasia/Hypoplasia of the patella (HP:0006498)1.95138978
124Increased connective tissue (HP:0009025)1.94570122
125Abnormality of transition element cation homeostasis (HP:0011030)1.93989924
126Hematochezia (HP:0002573)1.93435672
127Abnormality of methionine metabolism (HP:0010901)1.93405452
128Emphysema (HP:0002097)1.93404063
129Conjugated hyperbilirubinemia (HP:0002908)1.93311355
130Spastic diplegia (HP:0001264)1.92813072
131Abnormal platelet volume (HP:0011876)1.91580121
132Vasculitis (HP:0002633)1.91098050
133Aortic aneurysm (HP:0004942)1.91093676
134Tubular atrophy (HP:0000092)1.91000189
135Increased cerebral lipofuscin (HP:0011813)1.90597726
136Menorrhagia (HP:0000132)1.90190180
137Osteolytic defects of the phalanges of the hand (HP:0009771)1.89552912
138Osteolytic defects of the hand bones (HP:0009699)1.89552912
139Generalized hypopigmentation of hair (HP:0011358)1.88342215
140Inability to walk (HP:0002540)1.86924730
141Peritonitis (HP:0002586)1.86694743
142Alopecia of scalp (HP:0002293)1.86104756
143Abnormality of T cell physiology (HP:0011840)1.85918439
144Nephronophthisis (HP:0000090)1.85902706
145Recurrent abscess formation (HP:0002722)1.84710395
146Hypoplastic nipples (HP:0002557)1.84665930
147Upper limb amyotrophy (HP:0009129)1.84402424
148Distal upper limb amyotrophy (HP:0007149)1.84402424
149Abnormality of mucopolysaccharide metabolism (HP:0011020)1.84367083
150Abnormality of polysaccharide metabolism (HP:0011012)1.84367083
151Abnormality of glycosaminoglycan metabolism (HP:0004371)1.84367083
152Hemorrhage of the eye (HP:0011885)1.83682714
153Increased serum ferritin (HP:0003281)1.83192345
154IgG deficiency (HP:0004315)1.82397134
155Abnormality of the renal medulla (HP:0100957)1.81524817
156Hand muscle atrophy (HP:0009130)1.80830102
157Abnormality of the nasal mucosa (HP:0000433)1.80724588
158Macroglossia (HP:0000158)1.79576354
159Abnormality of pyrimidine metabolism (HP:0004353)1.79478873
160Diplopia (HP:0000651)1.78718119
161Abnormality of binocular vision (HP:0011514)1.78718119
162Widely spaced teeth (HP:0000687)1.77664728
163Protuberant abdomen (HP:0001538)1.77647946
164Cervical subluxation (HP:0003308)1.77411272
165Stroke (HP:0001297)1.76972317
166Obstructive sleep apnea (HP:0002870)1.76357809
167Malnutrition (HP:0004395)1.75783593
168Abnormality of macrophages (HP:0004311)1.75635562
169Hyperbilirubinemia (HP:0002904)1.75173770
170Hypertriglyceridemia (HP:0002155)1.74968000
171Abnormality of the renal cortex (HP:0011035)1.73404829
172Bicuspid aortic valve (HP:0001647)1.71529800
173Progressive inability to walk (HP:0002505)1.71471050
174Meningitis (HP:0001287)1.71110931
175Colitis (HP:0002583)1.70726554
176Chronic otitis media (HP:0000389)1.70561636
177Abnormality of the pericardium (HP:0001697)1.69462479
178Hypochromic anemia (HP:0001931)1.69276715
179Neoplasm of the heart (HP:0100544)1.69259711
180Tented upper lip vermilion (HP:0010804)1.68297295
181Increased corneal curvature (HP:0100692)1.68239167
182Keratoconus (HP:0000563)1.68239167
183Congenital sensorineural hearing impairment (HP:0008527)1.68087424
184Radial bowing (HP:0002986)1.67392898
185Cystic liver disease (HP:0006706)1.67129254
186Gingivitis (HP:0000230)1.66982311
187Agammaglobulinemia (HP:0004432)1.66614747
188Impaired smooth pursuit (HP:0007772)1.66238566
189Spondylolisthesis (HP:0003302)1.64198685
190Broad ribs (HP:0000885)1.64151749
191Long eyelashes (HP:0000527)1.64000299
192Abnormal drinking behavior (HP:0030082)1.63490693
193Polydipsia (HP:0001959)1.63490693
194Inflammation of the large intestine (HP:0002037)1.62768550
195Aneurysm (HP:0002617)1.62531550

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.31045452
2ERN13.86153159
3PKN23.21605808
4FGFR43.04414669
5SIK12.90485900
6ACVR1B2.86056714
7MAP4K12.80721372
8RIPK12.54383928
9EPHB12.53023488
10PRKG22.31244429
11TTN2.23939071
12AKT32.06389059
13TYK22.03994482
14PDK22.03705197
15TBK11.99543479
16PTK61.86381562
17ADRBK21.76364322
18JAK11.72163636
19KDR1.71727232
20BCKDK1.71160195
21MAP3K101.68825123
22BMPR1B1.67511679
23CDC42BPA1.65085343
24STK101.64965725
25ZAP701.52380744
26TNK21.49723374
27CAMK1D1.47887051
28KIT1.45072728
29JAK31.42829169
30EPHA31.42271434
31BLK1.41301678
32PRKD21.39097292
33MAP3K71.36465982
34TAOK31.36105363
35LRRK21.33690372
36LMTK21.33313478
37PIK3CG1.31090060
38MST1R1.30638179
39ITK1.30301397
40GRK61.28688016
41EEF2K1.22809261
42IKBKE1.21781811
43ADRBK11.20139060
44CSK1.17256193
45WNK41.15878155
46MARK21.15782403
47SIK21.15481070
48CAMKK21.13011676
49TGFBR21.09219146
50FES1.08071411
51HIPK21.06773418
52MAP2K61.06724184
53STK381.04793178
54GRK11.04318765
55MAPK151.03195719
56CAMK1G1.02561775
57CSF1R1.02395993
58JAK21.01536406
59MAP3K140.99023843
60TLK10.98441432
61FLT30.98431241
62MAPKAPK30.97603055
63MELK0.97129982
64STK160.96045588
65WNK10.94885300
66RPS6KA60.92219013
67NEK90.91473971
68TGFBR10.90928842
69MAPK110.89087709
70PAK30.87235334
71MARK30.86167409
72DAPK20.86086737
73FGFR30.83983769
74TYRO30.83912587
75SGK20.82953827
76PDPK10.78674099
77RIPK40.78390726
78PDK10.77664563
79MAP2K30.77254182
80MAPK120.76509349
81BTK0.75880777
82MAP3K30.74906475
83FER0.74144526
84MYLK0.73970984
85RET0.73716084
86HCK0.71629121
87FRK0.71085099
88TIE10.70107144
89BMX0.69977124
90IRAK10.69854965
91CAMK10.68437541
92NLK0.68107371
93STK110.67643918
94PTK20.66995894
95PDGFRA0.65884502
96LYN0.63510489
97MAPK130.62423632
98PDGFRB0.62061811
99SYK0.60796289
100LCK0.60642481
101CDK120.60571865
102RPS6KA20.60544262
103MAP3K130.60506818
104PRKAA20.59130782
105IRAK40.58261065
106MAP2K20.57728235
107TRPM70.54800082
108PAK40.54544152
109CDK40.53909238
110MET0.53784172
111SGK4940.52681875
112SGK2230.52681875
113MAPK70.52639010
114MAP2K10.51862064
115TESK10.51083011
116PIK3CA0.50258436
117RPS6KC10.49038175
118RPS6KL10.49038175
119FGFR20.47600069
120CDK60.47092149
121CHUK0.46852761
122TXK0.44350671
123PRKCH0.44152833
124MTOR0.43235949
125IKBKB0.42656158
126EGFR0.41804368
127ERBB20.41326437
128PRKCQ0.41260662
129SGK30.41136627
130ICK0.41021998
131MAPK40.40677429
132INSRR0.39706737
133PTK2B0.39494361
134DMPK0.38503689
135CAMKK10.38140019
136IGF1R0.37851840
137PRKAA10.37795145
138MAP3K20.36258934
139TEC0.35998239
140TESK20.35376429
141DYRK1B0.35317293
142CAMK2G0.34227779

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.54574388
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.06977063
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.93532080
4Staphylococcus aureus infection_Homo sapiens_hsa051502.59235759
5Fatty acid degradation_Homo sapiens_hsa000712.55350015
6Nitrogen metabolism_Homo sapiens_hsa009102.53231785
7Caffeine metabolism_Homo sapiens_hsa002322.45531216
8Complement and coagulation cascades_Homo sapiens_hsa046102.42980728
9Arginine biosynthesis_Homo sapiens_hsa002202.33883286
10Tryptophan metabolism_Homo sapiens_hsa003802.27032244
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.07309125
12PPAR signaling pathway_Homo sapiens_hsa033202.06130383
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.88519069
14Pentose and glucuronate interconversions_Homo sapiens_hsa000401.87623937
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.87376875
16Graft-versus-host disease_Homo sapiens_hsa053321.84209848
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.78118238
18Fatty acid metabolism_Homo sapiens_hsa012121.70995875
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.66963253
20Linoleic acid metabolism_Homo sapiens_hsa005911.65672692
21Bile secretion_Homo sapiens_hsa049761.65232530
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.62595252
23T cell receptor signaling pathway_Homo sapiens_hsa046601.62549578
24Allograft rejection_Homo sapiens_hsa053301.60249172
25Autoimmune thyroid disease_Homo sapiens_hsa053201.57855168
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.53950610
27Peroxisome_Homo sapiens_hsa041461.52862775
28Vascular smooth muscle contraction_Homo sapiens_hsa042701.52223469
29Lysine degradation_Homo sapiens_hsa003101.47499756
30Histidine metabolism_Homo sapiens_hsa003401.46981577
31Butanoate metabolism_Homo sapiens_hsa006501.45634580
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.45098212
33ABC transporters_Homo sapiens_hsa020101.41618484
34Propanoate metabolism_Homo sapiens_hsa006401.40127953
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.38795082
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37669815
37Dorso-ventral axis formation_Homo sapiens_hsa043201.36546172
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.35344120
39Fat digestion and absorption_Homo sapiens_hsa049751.33177769
40Selenocompound metabolism_Homo sapiens_hsa004501.29741024
41Chemical carcinogenesis_Homo sapiens_hsa052041.27553610
42Starch and sucrose metabolism_Homo sapiens_hsa005001.22363734
43Pyruvate metabolism_Homo sapiens_hsa006201.20787401
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18764569
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18749728
46beta-Alanine metabolism_Homo sapiens_hsa004101.18717393
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.17988447
48Drug metabolism - other enzymes_Homo sapiens_hsa009831.16790920
49Carbon metabolism_Homo sapiens_hsa012001.16149052
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.14388669
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13889100
52Glycerolipid metabolism_Homo sapiens_hsa005611.10450599
53Hematopoietic cell lineage_Homo sapiens_hsa046401.09293949
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08038928
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07420773
56Sulfur metabolism_Homo sapiens_hsa009201.06338370
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05396122
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04894758
59Vitamin digestion and absorption_Homo sapiens_hsa049771.02506839
60Type I diabetes mellitus_Homo sapiens_hsa049400.98986485
61Ether lipid metabolism_Homo sapiens_hsa005650.97740445
62Pentose phosphate pathway_Homo sapiens_hsa000300.95925794
63Phototransduction_Homo sapiens_hsa047440.95454698
64Phenylalanine metabolism_Homo sapiens_hsa003600.95300230
65Insulin resistance_Homo sapiens_hsa049310.94920665
66Asthma_Homo sapiens_hsa053100.94420316
67Chemokine signaling pathway_Homo sapiens_hsa040620.93565219
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.92509376
69Acute myeloid leukemia_Homo sapiens_hsa052210.92440341
70Biosynthesis of amino acids_Homo sapiens_hsa012300.90095901
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89463966
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.89268687
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89174768
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88688019
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87805886
76Viral myocarditis_Homo sapiens_hsa054160.87704026
77MAPK signaling pathway_Homo sapiens_hsa040100.86279586
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86209260
79Calcium signaling pathway_Homo sapiens_hsa040200.84729543
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83675660
81Osteoclast differentiation_Homo sapiens_hsa043800.83220516
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82010470
83VEGF signaling pathway_Homo sapiens_hsa043700.81540610
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81295755
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.80820460
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80202819
87FoxO signaling pathway_Homo sapiens_hsa040680.79464147
88Ovarian steroidogenesis_Homo sapiens_hsa049130.78991156
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78904899
90Cholinergic synapse_Homo sapiens_hsa047250.78007304
91Morphine addiction_Homo sapiens_hsa050320.77916127
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77756536
93Fatty acid biosynthesis_Homo sapiens_hsa000610.77361248
94Retinol metabolism_Homo sapiens_hsa008300.77292596
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.77264715
96Lysosome_Homo sapiens_hsa041420.76641219
97Oxytocin signaling pathway_Homo sapiens_hsa049210.75242728
98Leishmaniasis_Homo sapiens_hsa051400.74972404
99Galactose metabolism_Homo sapiens_hsa000520.73583027
100Choline metabolism in cancer_Homo sapiens_hsa052310.73403170
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71818429
102Primary immunodeficiency_Homo sapiens_hsa053400.70176212
103Prolactin signaling pathway_Homo sapiens_hsa049170.69806313
104Intestinal immune network for IgA production_Homo sapiens_hsa046720.68973880
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67011565
106GnRH signaling pathway_Homo sapiens_hsa049120.66537603
107Focal adhesion_Homo sapiens_hsa045100.66056519
108Circadian entrainment_Homo sapiens_hsa047130.65306946
109Gastric acid secretion_Homo sapiens_hsa049710.65239865
110Ras signaling pathway_Homo sapiens_hsa040140.64408067
111Other glycan degradation_Homo sapiens_hsa005110.63512017
112ECM-receptor interaction_Homo sapiens_hsa045120.63227439
113B cell receptor signaling pathway_Homo sapiens_hsa046620.63010187
114Arachidonic acid metabolism_Homo sapiens_hsa005900.62877103
115cAMP signaling pathway_Homo sapiens_hsa040240.62351070
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62005102
117Insulin secretion_Homo sapiens_hsa049110.61854830
118Tyrosine metabolism_Homo sapiens_hsa003500.61723485
119Fructose and mannose metabolism_Homo sapiens_hsa000510.61317329
120Notch signaling pathway_Homo sapiens_hsa043300.61091657
121African trypanosomiasis_Homo sapiens_hsa051430.60503472
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60017683
123Arginine and proline metabolism_Homo sapiens_hsa003300.58174794
124Serotonergic synapse_Homo sapiens_hsa047260.58077599
125Leukocyte transendothelial migration_Homo sapiens_hsa046700.57337782
126Salivary secretion_Homo sapiens_hsa049700.57303324
127Glutamatergic synapse_Homo sapiens_hsa047240.56933454
128Renin secretion_Homo sapiens_hsa049240.56876273
129Measles_Homo sapiens_hsa051620.56773689
130Circadian rhythm_Homo sapiens_hsa047100.55512925
131Protein digestion and absorption_Homo sapiens_hsa049740.54584857
132Pertussis_Homo sapiens_hsa051330.54490633
133Taste transduction_Homo sapiens_hsa047420.53870551
134Type II diabetes mellitus_Homo sapiens_hsa049300.53341472
135Long-term depression_Homo sapiens_hsa047300.53160714
136Amoebiasis_Homo sapiens_hsa051460.52277916
137Hepatitis C_Homo sapiens_hsa051600.51848952
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.51422760
139Toll-like receptor signaling pathway_Homo sapiens_hsa046200.51104657
140Toxoplasmosis_Homo sapiens_hsa051450.50547193
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50493171
142NF-kappa B signaling pathway_Homo sapiens_hsa040640.49862011
143Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49037863
144RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48633059
145Cysteine and methionine metabolism_Homo sapiens_hsa002700.46337071
146Platelet activation_Homo sapiens_hsa046110.43830324
147Antigen processing and presentation_Homo sapiens_hsa046120.40381281
148Mineral absorption_Homo sapiens_hsa049780.39892051
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39182434
150Folate biosynthesis_Homo sapiens_hsa007900.36875062
151Fatty acid elongation_Homo sapiens_hsa000620.35935576
152Influenza A_Homo sapiens_hsa051640.35114906
153Glutathione metabolism_Homo sapiens_hsa004800.34291355
154Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34126613
155Glucagon signaling pathway_Homo sapiens_hsa049220.33959376
156Malaria_Homo sapiens_hsa051440.32831942
157Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31253057
158Tuberculosis_Homo sapiens_hsa051520.31128405
159Legionellosis_Homo sapiens_hsa051340.30304193
160Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30072797
161Sulfur relay system_Homo sapiens_hsa041220.29968457
162AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.29326151
163TNF signaling pathway_Homo sapiens_hsa046680.29007520
164Small cell lung cancer_Homo sapiens_hsa052220.28692936
165Apoptosis_Homo sapiens_hsa042100.28531171
166Glycerophospholipid metabolism_Homo sapiens_hsa005640.28251003

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