PCYOX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Prenylcysteine is released during the degradation of prenylated proteins. PCYOX1 catalyzes the degradation of prenylcysteine to yield free cysteines and a hydrophobic isoprenoid product (Tschantz et al., 1999 [PubMed 10585463]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)5.46650872
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.46650872
3L-phenylalanine metabolic process (GO:0006558)5.20682182
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.20682182
5alpha-linolenic acid metabolic process (GO:0036109)5.10120422
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.73256014
7aromatic amino acid family catabolic process (GO:0009074)4.53260892
8negative regulation of fibrinolysis (GO:0051918)4.38615489
9bile acid biosynthetic process (GO:0006699)4.28818392
10glyoxylate metabolic process (GO:0046487)4.26118346
11peptidyl-glutamic acid carboxylation (GO:0017187)4.26032669
12protein carboxylation (GO:0018214)4.26032669
13complement activation, alternative pathway (GO:0006957)4.17048429
14high-density lipoprotein particle remodeling (GO:0034375)4.13127030
15regulation of protein activation cascade (GO:2000257)4.05749397
16regulation of fibrinolysis (GO:0051917)4.03932604
17lysine metabolic process (GO:0006553)4.02077685
18lysine catabolic process (GO:0006554)4.02077685
19kynurenine metabolic process (GO:0070189)4.00694204
20* sulfur amino acid catabolic process (GO:0000098)3.97786653
21cysteine metabolic process (GO:0006534)3.94012232
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.90196402
23urea cycle (GO:0000050)3.88263557
24urea metabolic process (GO:0019627)3.88263557
25reverse cholesterol transport (GO:0043691)3.86863062
26regulation of complement activation (GO:0030449)3.85793707
27plasma lipoprotein particle clearance (GO:0034381)3.80657060
28regulation of triglyceride catabolic process (GO:0010896)3.76912366
29tryptophan catabolic process (GO:0006569)3.72362090
30indole-containing compound catabolic process (GO:0042436)3.72362090
31indolalkylamine catabolic process (GO:0046218)3.72362090
32cellular ketone body metabolic process (GO:0046950)3.69330811
33bile acid metabolic process (GO:0008206)3.65321492
34positive regulation of fatty acid beta-oxidation (GO:0032000)3.63694224
35plasma lipoprotein particle remodeling (GO:0034369)3.60711160
36protein-lipid complex remodeling (GO:0034368)3.60711160
37macromolecular complex remodeling (GO:0034367)3.60711160
38tryptophan metabolic process (GO:0006568)3.59374911
39tyrosine metabolic process (GO:0006570)3.56455418
40nitrogen cycle metabolic process (GO:0071941)3.56098195
41homocysteine metabolic process (GO:0050667)3.55194718
42triglyceride homeostasis (GO:0070328)3.53550909
43acylglycerol homeostasis (GO:0055090)3.53550909
44amino-acid betaine metabolic process (GO:0006577)3.52868422
45phospholipid efflux (GO:0033700)3.41892925
46ethanol oxidation (GO:0006069)3.39412957
47positive regulation of lipid catabolic process (GO:0050996)3.39010453
48glutamate metabolic process (GO:0006536)3.38543355
49regulation of cholesterol esterification (GO:0010872)3.34254972
50short-chain fatty acid metabolic process (GO:0046459)3.31007052
51acetyl-CoA metabolic process (GO:0006084)3.29654737
52dicarboxylic acid biosynthetic process (GO:0043650)3.28636981
53alpha-amino acid catabolic process (GO:1901606)3.28521240
54cholesterol efflux (GO:0033344)3.26885485
55aromatic amino acid family metabolic process (GO:0009072)3.26296658
56serine family amino acid catabolic process (GO:0009071)3.23914602
57ketone body metabolic process (GO:1902224)3.23261068
58phospholipid homeostasis (GO:0055091)3.22971661
59coenzyme catabolic process (GO:0009109)3.22919779
60regulation of cholesterol homeostasis (GO:2000188)3.22900188
61negative regulation of lipase activity (GO:0060192)3.22394248
62regulation of fatty acid beta-oxidation (GO:0031998)3.22024719
63fatty acid beta-oxidation (GO:0006635)3.19780191
64very-low-density lipoprotein particle assembly (GO:0034379)3.18535555
65fibrinolysis (GO:0042730)3.17836022
66* cellular modified amino acid catabolic process (GO:0042219)3.16909180
67fatty acid oxidation (GO:0019395)3.15224211
68aspartate family amino acid catabolic process (GO:0009068)3.14377811
69positive regulation of fatty acid oxidation (GO:0046321)3.14042549
70negative regulation of sterol transport (GO:0032372)3.14023552
71negative regulation of cholesterol transport (GO:0032375)3.14023552
72* cellular amino acid catabolic process (GO:0009063)3.13016650
73epoxygenase P450 pathway (GO:0019373)3.12715453
74low-density lipoprotein particle clearance (GO:0034383)3.09258355
75lipid oxidation (GO:0034440)3.09248400
762-oxoglutarate metabolic process (GO:0006103)3.04621521
77monocarboxylic acid catabolic process (GO:0072329)3.02886458
78fatty acid catabolic process (GO:0009062)3.02399023
79intestinal cholesterol absorption (GO:0030299)2.99436210
80regulation of cholesterol biosynthetic process (GO:0045540)2.98157922
81very long-chain fatty acid metabolic process (GO:0000038)2.96966826
82plasma lipoprotein particle assembly (GO:0034377)2.94809114
83cellular glucuronidation (GO:0052695)2.94385277
84regulation of plasminogen activation (GO:0010755)2.94282827
85lipoprotein metabolic process (GO:0042157)2.94171254
86negative regulation of protein activation cascade (GO:2000258)2.93613919
87bile acid and bile salt transport (GO:0015721)2.93557136
88linoleic acid metabolic process (GO:0043651)2.92159492
89regulation of cholesterol metabolic process (GO:0090181)2.88738957
90benzene-containing compound metabolic process (GO:0042537)2.87987418
91* organic acid catabolic process (GO:0016054)2.87808962
92* carboxylic acid catabolic process (GO:0046395)2.87808962
93cholesterol homeostasis (GO:0042632)2.87620605
94drug catabolic process (GO:0042737)2.85974267
95positive regulation of triglyceride metabolic process (GO:0090208)2.85283032
96sterol homeostasis (GO:0055092)2.85103526
97fatty-acyl-CoA biosynthetic process (GO:0046949)2.85098669
98protein-lipid complex assembly (GO:0065005)2.84069669
99negative regulation of complement activation (GO:0045916)2.82059711
100regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.81260262
101positive regulation of fatty acid metabolic process (GO:0045923)2.79438538
102low-density lipoprotein particle remodeling (GO:0034374)2.78545168
103plasma lipoprotein particle organization (GO:0071827)2.78455511
104acylglycerol catabolic process (GO:0046464)2.77942066
105retina vasculature morphogenesis in camera-type eye (GO:0061299)2.70898047
106COPII vesicle coating (GO:0048208)2.70683394
107regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.64132463
108blood coagulation, intrinsic pathway (GO:0007597)2.58395473
109paraxial mesoderm development (GO:0048339)2.55572586
110cell adhesion mediated by integrin (GO:0033627)2.54495095
111fatty acid homeostasis (GO:0055089)2.44202951
112regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.40734012
113regulation of non-canonical Wnt signaling pathway (GO:2000050)2.40175075
1144-hydroxyproline metabolic process (GO:0019471)2.39870100
115neutral lipid catabolic process (GO:0046461)2.37772395
116embryonic retina morphogenesis in camera-type eye (GO:0060059)2.37579202
117intestinal absorption (GO:0050892)2.33639398
118triglyceride catabolic process (GO:0019433)2.28266836
119desmosome organization (GO:0002934)2.27610068
120collagen fibril organization (GO:0030199)2.26948209
121ethanol metabolic process (GO:0006067)2.25275450
122lipid particle organization (GO:0034389)2.24718337
123chondrocyte proliferation (GO:0035988)2.23069905
124lymphangiogenesis (GO:0001946)2.23049615
125endocardial cushion development (GO:0003197)2.21527667
126protein heterotrimerization (GO:0070208)2.21442834
127endodermal cell differentiation (GO:0035987)2.20877520
128polyketide metabolic process (GO:0030638)2.20793734
129doxorubicin metabolic process (GO:0044598)2.20793734
130daunorubicin metabolic process (GO:0044597)2.20793734
131L-serine transport (GO:0015825)2.20155178
132basement membrane organization (GO:0071711)2.19940067
133glomerular basement membrane development (GO:0032836)2.18489521
134biotin metabolic process (GO:0006768)2.18122212
135positive regulation of glycolytic process (GO:0045821)2.17905374
136hemidesmosome assembly (GO:0031581)2.17029554
137embryonic foregut morphogenesis (GO:0048617)2.16962465
138regulation of apoptotic cell clearance (GO:2000425)2.15467100
139peptidyl-proline hydroxylation (GO:0019511)2.13133165
140maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.12896119
141drug transmembrane transport (GO:0006855)2.11249086
142anterior/posterior axis specification, embryo (GO:0008595)2.11129427
143aminoglycoside antibiotic metabolic process (GO:0030647)2.08261570
144sequestering of extracellular ligand from receptor (GO:0035581)2.06706958
145protein hydroxylation (GO:0018126)2.05196395
146protein localization to cell surface (GO:0034394)2.04838659
147cellular response to vitamin (GO:0071295)2.04193200
148protein retention in ER lumen (GO:0006621)2.03897214
149substrate adhesion-dependent cell spreading (GO:0034446)2.03656283
150Golgi transport vesicle coating (GO:0048200)2.03200656
151COPI coating of Golgi vesicle (GO:0048205)2.03200656
152negative regulation of wound healing (GO:0061045)2.02842539
153positive regulation of blood coagulation (GO:0030194)2.02786788
154positive regulation of hemostasis (GO:1900048)2.02786788
155regulation of lipoprotein metabolic process (GO:0050746)2.01728622
156G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.00870156
157apoptotic cell clearance (GO:0043277)2.00716433
158negative regulation of blood coagulation (GO:0030195)1.98956928
159negative regulation of hemostasis (GO:1900047)1.98956928
160negative regulation of coagulation (GO:0050819)1.98417946
161cell proliferation involved in kidney development (GO:0072111)1.94871462

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.27786549
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.23297406
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.61829901
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.44352535
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.31631886
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.25438628
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.16445488
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.92894176
9CLOCK_20551151_ChIP-Seq_293T_Human2.45658046
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.19581783
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.18373308
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.17539680
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01434299
14RARG_19884340_ChIP-ChIP_MEFs_Mouse1.93289144
15WT1_19549856_ChIP-ChIP_CCG9911_Human1.92595528
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88206252
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79050003
18SALL1_21062744_ChIP-ChIP_HESCs_Human1.78903863
19RBPJ_22232070_ChIP-Seq_NCS_Mouse1.78022187
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69643738
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.69629516
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66441521
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.64168534
24FOXA2_19822575_ChIP-Seq_HepG2_Human1.57804205
25HIF1A_21447827_ChIP-Seq_MCF-7_Human1.55338102
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54041878
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.50012610
28TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.49667758
29TCF4_18268006_ChIP-ChIP_LS174T_Human1.49544081
30SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47351836
31ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.43455768
32TP53_16413492_ChIP-PET_HCT116_Human1.40924629
33SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.38797184
34NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38578361
35NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38578361
36CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.37846797
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.33934006
38HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.31560279
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.31246817
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30429320
41SMAD4_21799915_ChIP-Seq_A2780_Human1.29720750
42* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28563491
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28532836
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27166674
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26570914
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26561505
47ZNF263_19887448_ChIP-Seq_K562_Human1.26031649
48AR_21909140_ChIP-Seq_LNCAP_Human1.25922481
49TAF15_26573619_Chip-Seq_HEK293_Human1.25739417
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.23754265
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22933268
52SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.21176280
53CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20966737
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20105759
55FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18956328
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17709671
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.16779421
58BRD4_25478319_ChIP-Seq_HGPS_Human1.16357350
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15568919
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14908127
61TBX3_20139965_ChIP-Seq_ESCs_Mouse1.13371017
62TBX3_20139965_ChIP-Seq_MESCs_Mouse1.12948623
63ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12934503
64RNF2_18974828_ChIP-Seq_MESCs_Mouse1.11918837
65EZH2_18974828_ChIP-Seq_MESCs_Mouse1.11918837
66TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11427669
67FOXO3_23340844_ChIP-Seq_DLD1_Human1.11143517
68MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10146972
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09550145
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09447785
71SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07858168
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.07147759
73SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06159518
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.05644624
75ISL1_27105846_Chip-Seq_CPCs_Mouse1.05413884
76STAT3_23295773_ChIP-Seq_U87_Human1.04661559
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04615317
78PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03111897
79CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02468962
80ZNF274_21170338_ChIP-Seq_K562_Hela1.02413933
81PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02035884
82EOMES_21245162_ChIP-Seq_HESCs_Human1.01243598
83RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00773270
84SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00693015
85TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00570685
86MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.00509641
87SMAD3_21741376_ChIP-Seq_HESCs_Human1.00183330
88P300_19829295_ChIP-Seq_ESCs_Human0.99488675
89SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99408160
90SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99174639
91IGF1R_20145208_ChIP-Seq_DFB_Human0.98370046
92FLI1_27457419_Chip-Seq_LIVER_Mouse0.98176128
93YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98161179
94NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98150488
95SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.97789314
96NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97416014
97CDX2_22108803_ChIP-Seq_LS180_Human0.97143826
98MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96496019
99SOX2_20726797_ChIP-Seq_SW620_Human0.96221731
100STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96156993
101HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96059348
102AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95889197
103SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95288646
104* HNF4A_19822575_ChIP-Seq_HepG2_Human0.94661175
105DROSHA_22980978_ChIP-Seq_HELA_Human0.94425099
106LXR_22292898_ChIP-Seq_THP-1_Human0.94093202
107FUS_26573619_Chip-Seq_HEK293_Human0.93440487
108TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93271262
109EED_16625203_ChIP-ChIP_MESCs_Mouse0.93044078
110ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91279556
111JARID2_20075857_ChIP-Seq_MESCs_Mouse0.89759466
112WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88415165
113STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88264591
114BCAT_22108803_ChIP-Seq_LS180_Human0.87389428
115AHR_22903824_ChIP-Seq_MCF-7_Human0.86742048
116SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86035007
117AR_21572438_ChIP-Seq_LNCaP_Human0.85972704
118CJUN_26792858_Chip-Seq_BT549_Human0.85514378
119FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.84424768
120PIAS1_25552417_ChIP-Seq_VCAP_Human0.83591460
121TBX20_22080862_ChIP-Seq_HEART_Mouse0.83304888
122TBX20_22328084_ChIP-Seq_HEART_Mouse0.83304888
123NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.82949765
124WT1_25993318_ChIP-Seq_PODOCYTE_Human0.82693597
125KDM2B_26808549_Chip-Seq_K562_Human0.81659003
126NR3C1_23031785_ChIP-Seq_PC12_Mouse0.79589475
127P300_27058665_Chip-Seq_ZR-75-30cells_Human0.78746463
128* HTT_18923047_ChIP-ChIP_STHdh_Human0.78402233
129ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78019800
130RXR_22108803_ChIP-Seq_LS180_Human0.77696788
131ARNT_22903824_ChIP-Seq_MCF-7_Human0.77345148
132TP53_18474530_ChIP-ChIP_U2OS_Human0.77259008
133ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.76451731
134DNAJC2_21179169_ChIP-ChIP_NT2_Human0.76430135
135EZH2_27294783_Chip-Seq_ESCs_Mouse0.75459549
136GATA4_25053715_ChIP-Seq_YYC3_Human0.75219964
137AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.74511567
138TP63_23658742_ChIP-Seq_EP156T_Human0.73614543
139PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.73295910
140RACK7_27058665_Chip-Seq_MCF-7_Human0.72673533
141SUZ12_27294783_Chip-Seq_ESCs_Mouse0.72251386
142PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.71288775
143GBX2_23144817_ChIP-Seq_PC3_Human0.71280689
144Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.70485971
145EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.69914534
146GATA1_22025678_ChIP-Seq_K562_Human0.68511919
147SMAD4_21741376_ChIP-Seq_HESCs_Human0.68029992
148JARID2_20064375_ChIP-Seq_MESCs_Mouse0.67551037
149SOX2_21211035_ChIP-Seq_LN229_Gbm0.66707700
150CDX2_20551321_ChIP-Seq_CACO-2_Human0.66474608
151RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.66247803

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.24787458
2MP0005360_urolithiasis5.63550239
3MP0005365_abnormal_bile_salt4.62015792
4MP0005085_abnormal_gallbladder_physiolo4.61265649
5MP0008875_abnormal_xenobiotic_pharmacok3.64439585
6MP0010329_abnormal_lipoprotein_level3.20005958
7MP0003252_abnormal_bile_duct3.14989168
8MP0008438_abnormal_cutaneous_collagen2.83245908
9MP0009840_abnormal_foam_cell2.70814670
10MP0003705_abnormal_hypodermis_morpholog2.70035964
11MP0003941_abnormal_skin_development2.57718785
12MP0003806_abnormal_nucleotide_metabolis2.54674672
13MP0005083_abnormal_biliary_tract2.44029209
14MP0003195_calcinosis2.43373608
15MP0003191_abnormal_cellular_cholesterol2.39071952
16MP0005332_abnormal_amino_acid2.18770436
17MP0001666_abnormal_nutrient_absorption2.15604849
18MP0005275_abnormal_skin_tensile2.12372176
19MP0002118_abnormal_lipid_homeostasis2.01088572
20MP0005257_abnormal_intraocular_pressure1.92628323
21MP0003122_maternal_imprinting1.83030338
22MP0004130_abnormal_muscle_cell1.81369585
23MP0010234_abnormal_vibrissa_follicle1.80103580
24MP0003329_amyloid_beta_deposits1.70578244
25MP0000609_abnormal_liver_physiology1.64928481
26MP0003950_abnormal_plasma_membrane1.62555516
27MP0002938_white_spotting1.58135362
28MP0000604_amyloidosis1.57366826
29MP0004019_abnormal_vitamin_homeostasis1.53956869
30MP0009780_abnormal_chondrocyte_physiolo1.52973881
31MP0010030_abnormal_orbit_morphology1.50987170
32MP0001299_abnormal_eye_distance/1.49170543
33MP0002837_dystrophic_cardiac_calcinosis1.36727711
34MP0005319_abnormal_enzyme/_coenzyme1.32766181
35MP0003868_abnormal_feces_composition1.32228407
36MP0005670_abnormal_white_adipose1.31849295
37MP0002108_abnormal_muscle_morphology1.31296721
38MP0005584_abnormal_enzyme/coenzyme_acti1.29749901
39MP0003690_abnormal_glial_cell1.28576828
40MP0000566_synostosis1.28346787
41MP0005058_abnormal_lysosome_morphology1.27992433
42MP0004272_abnormal_basement_membrane1.24192561
43MP0004185_abnormal_adipocyte_glucose1.23433567
44MP0002796_impaired_skin_barrier1.22725358
45MP0009384_cardiac_valve_regurgitation1.21504580
46MP0005666_abnormal_adipose_tissue1.20006729
47MP0005409_darkened_coat_color1.19475500
48MP0000749_muscle_degeneration1.17289684
49MP0003385_abnormal_body_wall1.15514103
50MP0002876_abnormal_thyroid_physiology1.15453744
51MP0002254_reproductive_system_inflammat1.13654253
52MP0000534_abnormal_ureter_morphology1.12808981
53MP0004084_abnormal_cardiac_muscle1.10763896
54MP0009643_abnormal_urine_homeostasis1.10120720
55MP0000013_abnormal_adipose_tissue1.08878099
56MP0004215_abnormal_myocardial_fiber1.08750609
57MP0003942_abnormal_urinary_system1.06721412
58MP0002060_abnormal_skin_morphology1.03614081
59MP0006138_congestive_heart_failure1.01146182
60MP0001661_extended_life_span1.00545722
61MP0003890_abnormal_embryonic-extraembry1.00390601
62MP0005330_cardiomyopathy1.00060260
63MP0002971_abnormal_brown_adipose0.99686436
64MP0003937_abnormal_limbs/digits/tail_de0.96656392
65MP0002295_abnormal_pulmonary_circulatio0.95158175
66MP0008775_abnormal_heart_ventricle0.94576622
67MP0005375_adipose_tissue_phenotype0.93654357
68MP0010368_abnormal_lymphatic_system0.92165486
69MP0000762_abnormal_tongue_morphology0.91381655
70MP0002138_abnormal_hepatobiliary_system0.91056121
71MP0002090_abnormal_vision0.89876595
72MP0004233_abnormal_muscle_weight0.89441562
73MP0002078_abnormal_glucose_homeostasis0.88588505
74MP0001879_abnormal_lymphatic_vessel0.88478608
75MP0004858_abnormal_nervous_system0.88469284
76MP0000767_abnormal_smooth_muscle0.88032872
77MP0009053_abnormal_anal_canal0.87273488
78MP0004087_abnormal_muscle_fiber0.87091572
79MP0004133_heterotaxia0.86804314
80MP0002909_abnormal_adrenal_gland0.85482225
81MP0000579_abnormal_nail_morphology0.85132314
82MP0005451_abnormal_body_composition0.84918130
83MP0005334_abnormal_fat_pad0.84655611
84MP0003011_delayed_dark_adaptation0.84211676
85MP0004036_abnormal_muscle_relaxation0.83969885
86MP0000462_abnormal_digestive_system0.83925332
87MP0005508_abnormal_skeleton_morphology0.83588855
88MP0002697_abnormal_eye_size0.82283483
89MP0005535_abnormal_body_temperature0.81338950
90MP0002233_abnormal_nose_morphology0.80289785
91MP0005503_abnormal_tendon_morphology0.79658561
92MP0005369_muscle_phenotype0.79648738
93MP0000003_abnormal_adipose_tissue0.78866650
94MP0003283_abnormal_digestive_organ0.78857200
95MP0005620_abnormal_muscle_contractility0.78420230
96MP0000598_abnormal_liver_morphology0.78018081
97MP0003300_gastrointestinal_ulcer0.77929481
98MP0009250_abnormal_appendicular_skeleto0.77797136
99MP0005220_abnormal_exocrine_pancreas0.77788941
100MP0002896_abnormal_bone_mineralization0.77435860
101MP0001756_abnormal_urination0.77391278
102MP0001915_intracranial_hemorrhage0.76648040
103MP0000428_abnormal_craniofacial_morphol0.75391544
104MP0003755_abnormal_palate_morphology0.75190197
105MP0003656_abnormal_erythrocyte_physiolo0.74202650
106MP0003075_altered_response_to0.73557249
107MP0003566_abnormal_cell_adhesion0.72769610
108MP0005408_hypopigmentation0.72760275
109MP0002168_other_aberrant_phenotype0.72271997
110MP0005647_abnormal_sex_gland0.70993863
111MP0001958_emphysema0.69995568
112MP0000163_abnormal_cartilage_morphology0.69819827
113MP0000639_abnormal_adrenal_gland0.69554107
114MP0004782_abnormal_surfactant_physiolog0.69420684
115MP0002972_abnormal_cardiac_muscle0.69396628
116MP0005448_abnormal_energy_balance0.67433815
117MP0002106_abnormal_muscle_physiology0.66667959
118MP0002128_abnormal_blood_circulation0.66631729
119MP0000759_abnormal_skeletal_muscle0.63972807
120MP0005248_abnormal_Harderian_gland0.63695652
121MP0003935_abnormal_craniofacial_develop0.63273158
122MP0009697_abnormal_copulation0.62111159
123MP0001764_abnormal_homeostasis0.61961388
124MP0009642_abnormal_blood_homeostasis0.61761699
125MP0005197_abnormal_uvea_morphology0.61448477
126MP0005623_abnormal_meninges_morphology0.60927770
127MP0005636_abnormal_mineral_homeostasis0.59975319
128MP0005023_abnormal_wound_healing0.59908791
129MP0003959_abnormal_lean_body0.59161131
130MP0006054_spinal_hemorrhage0.59097824
131MP0002115_abnormal_skeleton_extremities0.59083856
132MP0000751_myopathy0.58780087
133MP0005187_abnormal_penis_morphology0.56097913
134MP0000427_abnormal_hair_cycle0.55603400
135MP0003172_abnormal_lysosome_physiology0.54876367
136MP0000747_muscle_weakness0.52985154
137MP0000920_abnormal_myelination0.52877950
138MP0004043_abnormal_pH_regulation0.52597685
139MP0001177_atelectasis0.52013227
140MP0009763_increased_sensitivity_to0.51742839
141MP0000538_abnormal_urinary_bladder0.51481801
142MP0003279_aneurysm0.51472863
143MP0003453_abnormal_keratinocyte_physiol0.50689986
144MP0001243_abnormal_dermal_layer0.50637728
145MP0000467_abnormal_esophagus_morphology0.49883696
146MP0000230_abnormal_systemic_arterial0.49401402
147MP0005164_abnormal_response_to0.49369094
148MP0008961_abnormal_basal_metabolism0.49305625
149MP0010678_abnormal_skin_adnexa0.49009625
150MP0003186_abnormal_redox_activity0.48683495
151MP0003953_abnormal_hormone_level0.48175810
152MP0002269_muscular_atrophy0.46572973

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.97991953
2Xanthomatosis (HP:0000991)5.25478740
3Intrahepatic cholestasis (HP:0001406)5.06788339
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.00623919
5Complement deficiency (HP:0004431)4.49086180
6Hyperlipoproteinemia (HP:0010980)4.37800277
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.33007952
8Hypobetalipoproteinemia (HP:0003563)4.08876836
9Prolonged partial thromboplastin time (HP:0003645)4.04964934
10Epidermoid cyst (HP:0200040)3.79881971
11Ketosis (HP:0001946)3.76854847
12Hypoalphalipoproteinemia (HP:0003233)3.65270711
13Hypolipoproteinemia (HP:0010981)3.61052156
14Hyperammonemia (HP:0001987)3.58415343
15Vascular tortuosity (HP:0004948)3.48985454
16Abnormality of the common coagulation pathway (HP:0010990)3.48640485
17Hypoglycemic coma (HP:0001325)3.46385898
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.41463860
19Hyperglycinemia (HP:0002154)3.26905326
20Abnormality of complement system (HP:0005339)3.24662705
21Abnormality of serine family amino acid metabolism (HP:0010894)3.24058021
22Abnormality of glycine metabolism (HP:0010895)3.24058021
23Abnormality of glutamine family amino acid metabolism (HP:0010902)3.23840447
24Ketoacidosis (HP:0001993)3.18742991
25Hyperglycinuria (HP:0003108)3.14373565
26Skin nodule (HP:0200036)3.05830835
27Joint hemorrhage (HP:0005261)3.01062987
28Abnormality of the intrinsic pathway (HP:0010989)2.92363118
29Arterial tortuosity (HP:0005116)2.91616259
30Aortic dissection (HP:0002647)2.83426715
31Fat malabsorption (HP:0002630)2.81849425
32Abnormality of sulfur amino acid metabolism (HP:0004339)2.81194185
33Abnormality of fatty-acid metabolism (HP:0004359)2.80864520
34Hypercholesterolemia (HP:0003124)2.79839093
35Aortic aneurysm (HP:0004942)2.74968474
36Type 1 muscle fiber predominance (HP:0003803)2.73179712
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.66477887
38Myocardial infarction (HP:0001658)2.61656408
39Abnormality of aspartate family amino acid metabolism (HP:0010899)2.57314350
40Protrusio acetabuli (HP:0003179)2.48163964
41Ankle contracture (HP:0006466)2.45621071
42Follicular hyperkeratosis (HP:0007502)2.45523869
43Coronal craniosynostosis (HP:0004440)2.44886549
44Soft skin (HP:0000977)2.44824588
45Turricephaly (HP:0000262)2.44346184
46Neurofibrillary tangles (HP:0002185)2.42194706
47Amyloidosis (HP:0011034)2.40843982
48Premature rupture of membranes (HP:0001788)2.38617296
49Abnormality of methionine metabolism (HP:0010901)2.38100328
50Cerebral inclusion bodies (HP:0100314)2.36239661
51Conjugated hyperbilirubinemia (HP:0002908)2.34167204
52Hepatocellular carcinoma (HP:0001402)2.33173639
53Mitral stenosis (HP:0001718)2.27490406
54Abnormality of the Achilles tendon (HP:0005109)2.26201674
55Hypoglycemic seizures (HP:0002173)2.25838050
56Abnormality of purine metabolism (HP:0004352)2.24163041
57Spinal rigidity (HP:0003306)2.24111949
58Cervical subluxation (HP:0003308)2.23969138
59Systemic lupus erythematosus (HP:0002725)2.20704286
60Peritonitis (HP:0002586)2.20277367
61Gout (HP:0001997)2.19581566
62Abnormal gallbladder physiology (HP:0012438)2.18211062
63Cholecystitis (HP:0001082)2.18211062
64Delayed CNS myelination (HP:0002188)2.17322389
65Spastic diplegia (HP:0001264)2.17122659
66Papillary thyroid carcinoma (HP:0002895)2.16742818
67Atrophic scars (HP:0001075)2.14897035
68Neonatal onset (HP:0003623)2.14303734
69Back pain (HP:0003418)2.13918722
70Hyperbilirubinemia (HP:0002904)2.09844960
71Neonatal short-limb short stature (HP:0008921)2.07408334
72Abnormal gallbladder morphology (HP:0012437)2.07175689
73Wormian bones (HP:0002645)2.06693795
74Abnormal delivery (HP:0001787)2.06543060
75Broad metatarsal (HP:0001783)2.05283263
76Sensorimotor neuropathy (HP:0007141)2.04797440
77Bladder diverticulum (HP:0000015)2.04727539
78Right ventricular cardiomyopathy (HP:0011663)2.04406781
79Cholelithiasis (HP:0001081)2.03455128
80Glomerulonephritis (HP:0000099)2.01810346
81Cardiovascular calcification (HP:0011915)2.01621709
82Abnormality of carpal bone ossification (HP:0006257)2.00185890
83Abnormality of proline metabolism (HP:0010907)1.98425522
84Hydroxyprolinuria (HP:0003080)1.98425522
85Microglossia (HP:0000171)1.98107006
86Vertebral compression fractures (HP:0002953)1.97654932
87Steatorrhea (HP:0002570)1.96566335
88Vascular calcification (HP:0004934)1.94249275
89Abnormality of nucleobase metabolism (HP:0010932)1.93594312
90Lymphangioma (HP:0100764)1.93544054
91Abnormality of dicarboxylic acid metabolism (HP:0010995)1.91828184
92Dicarboxylic aciduria (HP:0003215)1.91828184
93Vertebral arch anomaly (HP:0008438)1.91456453
94Metabolic acidosis (HP:0001942)1.90076829
95Late onset (HP:0003584)1.88820101
96Hyperinsulinemic hypoglycemia (HP:0000825)1.88614650
97Abnormality of serum amino acid levels (HP:0003112)1.87289669
98Myoglobinuria (HP:0002913)1.83929756
99Abnormal cartilage morphology (HP:0002763)1.83700289
100Abnormality of dentin (HP:0010299)1.82785062
101Esophageal varix (HP:0002040)1.82564323
102Hemorrhage of the eye (HP:0011885)1.82512313
103Aplasia of the phalanges of the hand (HP:0009802)1.78310973
104Aplasia involving bones of the extremities (HP:0009825)1.78310973
105Aplasia involving bones of the upper limbs (HP:0009823)1.78310973
106Achilles tendon contracture (HP:0001771)1.77616103
107Muscle fiber inclusion bodies (HP:0100299)1.76810197
108Malnutrition (HP:0004395)1.76623345
109Nemaline bodies (HP:0003798)1.75917932
110Protuberant abdomen (HP:0001538)1.75361032
111Irritability (HP:0000737)1.75001187
112Ovoid vertebral bodies (HP:0003300)1.74852001
113Abnormality of the acetabulum (HP:0003170)1.74078238
114Nephritis (HP:0000123)1.72782385
115Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.72461583
116Prominent supraorbital ridges (HP:0000336)1.71834866
117Hyperglycemia (HP:0003074)1.71621145
118Cerebral aneurysm (HP:0004944)1.71181078
119Abnormality of the gallbladder (HP:0005264)1.71038231
120Small epiphyses (HP:0010585)1.71016195
121Spontaneous abortion (HP:0005268)1.70798295
122Infantile muscular hypotonia (HP:0008947)1.70419289
123Torticollis (HP:0000473)1.69930257
124Stroke (HP:0001297)1.69428695
125Limited hip movement (HP:0008800)1.67456761
126Wide anterior fontanel (HP:0000260)1.67251088
127Hyporeflexia of lower limbs (HP:0002600)1.66956519
128Urinary glycosaminoglycan excretion (HP:0003541)1.65803824
129Mucopolysacchariduria (HP:0008155)1.65803824
130Increased variability in muscle fiber diameter (HP:0003557)1.62658370
131Arthropathy (HP:0003040)1.61708484
132Hypophosphatemic rickets (HP:0004912)1.61436650
133Acanthosis nigricans (HP:0000956)1.60918968
134Pancreatitis (HP:0001733)1.60431315
135Hyperextensible skin (HP:0000974)1.59419159
136Abnormal hand bone ossification (HP:0010660)1.58811160
137Proximal tubulopathy (HP:0000114)1.58212990
138Craniofacial dystonia (HP:0012179)1.57693139
139Striae distensae (HP:0001065)1.57409229
140Long toe (HP:0010511)1.57063828
141Shallow orbits (HP:0000586)1.56549701
142Exercise-induced myalgia (HP:0003738)1.55781695
143Abnormality of the calf musculature (HP:0001430)1.53995366
144Mitral valve prolapse (HP:0001634)1.53608652
145Short tibia (HP:0005736)1.51322403
146Pancreatic islet-cell hyperplasia (HP:0004510)1.49739343
147Exercise-induced muscle cramps (HP:0003710)1.48866551
148Hepatoblastoma (HP:0002884)1.47924550
149Overgrowth (HP:0001548)1.47491941
150Vaginal fistula (HP:0004320)1.47448827
151Bowel diverticulosis (HP:0005222)1.46148196
152Abnormal ossification of hand bones (HP:0005921)1.42175975
153Ulnar bowing (HP:0003031)1.41132125
154Myelomeningocele (HP:0002475)1.39056838
155Increased serum pyruvate (HP:0003542)1.38805138
156Coxa vara (HP:0002812)1.38299249
157Aplasia/Hypoplasia of the tibia (HP:0005772)1.38014317
158Blue sclerae (HP:0000592)1.38005169
159Advanced eruption of teeth (HP:0006288)1.37526380

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.88115036
2BCKDK3.34387446
3SIK13.29300949
4ERN13.05529422
5PKN22.58903757
6MYLK2.31432712
7AKT32.21873951
8OBSCN2.15484916
9PNCK2.11215758
10RIPK12.11192437
11STK38L2.09783652
12LATS12.02659985
13DDR21.91064612
14MAP4K21.88587207
15PDGFRA1.87223477
16NTRK11.84720465
17FGFR41.83339343
18FGFR21.78911378
19MAP2K41.75793496
20INSRR1.67041983
21FER1.65846174
22MAP3K21.60967602
23PTK61.58954714
24MST1R1.58825753
25MET1.58796240
26TTN1.57949085
27KSR21.54774248
28WNK31.54018893
29ERBB41.50168097
30DAPK21.49013060
31CAMK1D1.48202033
32FRK1.47258374
33PAK31.47177451
34LMTK21.35691541
35RET1.34882429
36PHKG21.33084397
37PHKG11.33084397
38EPHB11.30596244
39LATS21.30067159
40CAMK1G1.26565307
41BCR1.21104209
42ERBB31.20395820
43FGFR31.20058301
44PTK21.19643599
45STK31.13867235
46EPHB21.11561959
47ACVR1B1.11239818
48PAK61.08561958
49MAP3K91.08497403
50EPHA41.08424477
51TIE11.00110497
52MAP2K10.99537246
53CAMKK10.98054014
54CASK0.98009231
55PIK3CG0.94312569
56WNK40.91270295
57STK240.87732743
58BMX0.86353792
59GRK10.85662505
60PINK10.85308725
61TAOK30.82111857
62PRKCE0.80017031
63MINK10.79931011
64BMPR1B0.79790236
65FLT30.79504980
66PBK0.77420560
67MAP3K120.77174588
68BRSK20.76581894
69PRKD30.76422327
70PDPK10.76375106
71ERBB20.76128746
72MAPKAPK30.75604731
73WNK10.75396932
74STK390.74888620
75MAP3K70.74500297
76EPHA20.74426026
77PRKCH0.74278823
78DMPK0.74070576
79FGFR10.73036195
80LRRK20.70397085
81EPHA30.70022365
82PRKCG0.70017538
83NEK90.70008536
84SCYL20.69380187
85MARK10.68453343
86PAK20.68285917
87ABL20.68164162
88TESK10.67111475
89TGFBR20.66677287
90MAPK110.65030631
91TYRO30.63990832
92PDGFRB0.63962450
93NEK10.63796313
94DYRK1B0.63530970
95PRKD10.63343278
96NTRK30.62900188
97SGK20.62092889
98ICK0.61980125
99MAP3K40.61617554
100MAP3K10.60729995
101JAK20.60697631
102CAMK2G0.60667017
103GSK3A0.60506890
104PRKCZ0.59658788
105PDK40.58634841
106PDK30.58634841
107KSR10.57452321
108PRKAA20.57191709
109SGK4940.53500182
110SGK2230.53500182
111ROCK10.52674107
112PLK20.52623775
113ADRBK10.52522203
114OXSR10.52286021
115CSNK1G20.51608209
116CCNB10.51243906
117CAMK2D0.51141458
118PIK3CA0.51003697
119JAK10.50657199
120CDK60.50333851
121STK380.50256821
122CAMK10.49433862
123MELK0.48754539
124EIF2AK30.48372530
125PRKACG0.48281320
126PTK2B0.48123778
127CDK50.46678125
128PDK20.46108582
129MTOR0.45122269
130SGK30.44859728
131TRPM70.44623227
132CSNK1E0.44044074
133RPS6KB10.43516419
134PRKG10.42968919
135PRKACB0.42949968
136MAP3K60.42690981
137LIMK10.42599140
138MAP3K30.41016938
139PDK10.40796454
140PRKAA10.39121042
141IGF1R0.38619210
142CAMKK20.38214977
143DAPK30.37595181

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.78872166
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.57110179
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.75278644
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.68385447
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.63809404
6Fatty acid degradation_Homo sapiens_hsa000712.62812855
7Arginine biosynthesis_Homo sapiens_hsa002202.58214333
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.51048464
9Complement and coagulation cascades_Homo sapiens_hsa046102.31106414
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.28860010
11Tryptophan metabolism_Homo sapiens_hsa003802.26216522
12Butanoate metabolism_Homo sapiens_hsa006502.23122133
13Fatty acid metabolism_Homo sapiens_hsa012122.18806804
14Propanoate metabolism_Homo sapiens_hsa006402.16592157
15PPAR signaling pathway_Homo sapiens_hsa033202.06304055
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.83270041
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.78531510
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73733990
19Peroxisome_Homo sapiens_hsa041461.70508996
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.64018796
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.63898479
22beta-Alanine metabolism_Homo sapiens_hsa004101.58564533
23Histidine metabolism_Homo sapiens_hsa003401.56601686
24Bile secretion_Homo sapiens_hsa049761.54785546
25Chemical carcinogenesis_Homo sapiens_hsa052041.46555610
26Caffeine metabolism_Homo sapiens_hsa002321.45882125
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.45770298
28Sulfur metabolism_Homo sapiens_hsa009201.44809076
29Fatty acid elongation_Homo sapiens_hsa000621.44400321
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.41627820
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.41206036
32Pyruvate metabolism_Homo sapiens_hsa006201.39751475
33Staphylococcus aureus infection_Homo sapiens_hsa051501.35548466
34Phenylalanine metabolism_Homo sapiens_hsa003601.33301775
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.30560738
36* Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28661846
37Starch and sucrose metabolism_Homo sapiens_hsa005001.23638716
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21530802
39Fat digestion and absorption_Homo sapiens_hsa049751.20868370
40Tyrosine metabolism_Homo sapiens_hsa003501.20031495
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15940216
42Retinol metabolism_Homo sapiens_hsa008301.15811562
43Steroid biosynthesis_Homo sapiens_hsa001001.13473310
44Carbon metabolism_Homo sapiens_hsa012001.12610669
45Fatty acid biosynthesis_Homo sapiens_hsa000611.08235949
46Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.06757579
47ABC transporters_Homo sapiens_hsa020100.99871957
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97699213
49Selenocompound metabolism_Homo sapiens_hsa004500.96798869
50Dilated cardiomyopathy_Homo sapiens_hsa054140.95332188
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94382747
52Biosynthesis of amino acids_Homo sapiens_hsa012300.92319851
53Glycerolipid metabolism_Homo sapiens_hsa005610.88779309
54Circadian rhythm_Homo sapiens_hsa047100.88070451
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.87435348
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87320955
57TGF-beta signaling pathway_Homo sapiens_hsa043500.83289782
58Protein export_Homo sapiens_hsa030600.81338434
59Hippo signaling pathway_Homo sapiens_hsa043900.79333124
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.75993269
61Lysine degradation_Homo sapiens_hsa003100.72929040
62Arginine and proline metabolism_Homo sapiens_hsa003300.72475168
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71206987
64Adherens junction_Homo sapiens_hsa045200.68671752
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.66725134
66Basal cell carcinoma_Homo sapiens_hsa052170.66508224
67Vitamin digestion and absorption_Homo sapiens_hsa049770.61982391
68Hedgehog signaling pathway_Homo sapiens_hsa043400.57909369
69Prion diseases_Homo sapiens_hsa050200.57066463
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.56369904
71Insulin resistance_Homo sapiens_hsa049310.55453392
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.55419934
73N-Glycan biosynthesis_Homo sapiens_hsa005100.53915937
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53214098
75Sphingolipid metabolism_Homo sapiens_hsa006000.52548472
76Mineral absorption_Homo sapiens_hsa049780.52459599
77Tight junction_Homo sapiens_hsa045300.50926893
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50270012
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48129253
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47241283
81Folate biosynthesis_Homo sapiens_hsa007900.43680672
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43513568
83Axon guidance_Homo sapiens_hsa043600.42967825
84Lysosome_Homo sapiens_hsa041420.42129992
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41966681
86Glutathione metabolism_Homo sapiens_hsa004800.40803962
87Renin-angiotensin system_Homo sapiens_hsa046140.39048244
88Glucagon signaling pathway_Homo sapiens_hsa049220.38776281
89Wnt signaling pathway_Homo sapiens_hsa043100.38371223
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38275147
91Sulfur relay system_Homo sapiens_hsa041220.38083661
92AMPK signaling pathway_Homo sapiens_hsa041520.37104844
93Vitamin B6 metabolism_Homo sapiens_hsa007500.36037306
94ECM-receptor interaction_Homo sapiens_hsa045120.35147120
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34897837
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33953373
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.33203441
98Insulin signaling pathway_Homo sapiens_hsa049100.30985541
99Ovarian steroidogenesis_Homo sapiens_hsa049130.29524232
100Amoebiasis_Homo sapiens_hsa051460.29485368
101Pentose phosphate pathway_Homo sapiens_hsa000300.25500693
102Protein digestion and absorption_Homo sapiens_hsa049740.24574332
103Bladder cancer_Homo sapiens_hsa052190.23104352
104Thyroid hormone synthesis_Homo sapiens_hsa049180.21641676
105Metabolic pathways_Homo sapiens_hsa011000.21396133
106Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.20985156
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.20479493
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19257006
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.19011870
110Type II diabetes mellitus_Homo sapiens_hsa049300.18630413
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.16719072
112Focal adhesion_Homo sapiens_hsa045100.16652043
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16096621
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15970414
115Galactose metabolism_Homo sapiens_hsa000520.15819429
116Aldosterone synthesis and secretion_Homo sapiens_hsa049250.13569517
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.12763776
118GABAergic synapse_Homo sapiens_hsa047270.10365463
119Proteoglycans in cancer_Homo sapiens_hsa052050.10037284
120Insulin secretion_Homo sapiens_hsa049110.07599966
121Glioma_Homo sapiens_hsa052140.06473015
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.05942287
123Renin secretion_Homo sapiens_hsa049240.05862910

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