PCYOX1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)7.23574231
2maintenance of protein location in nucleus (GO:0051457)6.68463808
3regulation of mammary gland epithelial cell proliferation (GO:0033599)6.57198713
4regulation of nuclear cell cycle DNA replication (GO:0033262)6.52822367
5regulation of B cell receptor signaling pathway (GO:0050855)6.48487352
6protein localization to kinetochore (GO:0034501)6.33023346
7negative regulation of telomerase activity (GO:0051974)6.12295077
8somite rostral/caudal axis specification (GO:0032525)6.07384570
9regulation of telomere maintenance via telomerase (GO:0032210)6.07250781
10negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)6.04456635
11negative regulation of epidermis development (GO:0045683)5.92552244
12negative regulation of cell killing (GO:0031342)5.86383146
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.86383146
14negative regulation of cell cycle G2/M phase transition (GO:1902750)5.77627044
15regulation of response to osmotic stress (GO:0047484)5.68473962
16rRNA transcription (GO:0009303)5.67127339
17histone H4-K12 acetylation (GO:0043983)5.48871105
18histone H4-K8 acetylation (GO:0043982)5.48647791
19histone H4-K5 acetylation (GO:0043981)5.48647791
20negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.23093165
21mitotic sister chromatid segregation (GO:0000070)5.18527833
22positive regulation of gamma-delta T cell activation (GO:0046645)5.15713736
23positive regulation of DNA-dependent DNA replication (GO:2000105)4.97880695
24regulation of MHC class I biosynthetic process (GO:0045343)4.83947120
25negative regulation of telomere maintenance (GO:0032205)4.78522620
26negative thymic T cell selection (GO:0045060)4.76767377
27response to interleukin-15 (GO:0070672)4.70756346
28negative regulation of epidermal cell differentiation (GO:0045605)4.67052375
29protein localization to chromosome, centromeric region (GO:0071459)4.66370090
30DNA replication checkpoint (GO:0000076)4.65401741
31regulation of cilium movement (GO:0003352)4.63973153
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.59803164
33muscle organ morphogenesis (GO:0048644)4.55762489
34negative T cell selection (GO:0043383)4.52527681
35DNA replication-dependent nucleosome assembly (GO:0006335)4.50995462
36DNA replication-dependent nucleosome organization (GO:0034723)4.50995462
37rRNA methylation (GO:0031167)4.49311023
38regulation of apoptotic process involved in morphogenesis (GO:1902337)4.46940281
39thymic T cell selection (GO:0045061)4.45425455
40quinone metabolic process (GO:1901661)4.39352196
41response to dietary excess (GO:0002021)4.39161593
42notochord development (GO:0030903)4.38110943
43heterochromatin organization (GO:0070828)4.36878024
44positive thymic T cell selection (GO:0045059)4.36331643
45nucleoside transmembrane transport (GO:1901642)4.31872690
46negative regulation of erythrocyte differentiation (GO:0045647)4.31621060
47sister chromatid segregation (GO:0000819)4.31009904
48positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.27827511
49positive regulation of B cell differentiation (GO:0045579)4.25015534
50cullin deneddylation (GO:0010388)4.22711878
51cytidine deamination (GO:0009972)4.20053086
52cytidine metabolic process (GO:0046087)4.20053086
53cytidine catabolic process (GO:0006216)4.20053086
54rRNA modification (GO:0000154)4.19201265
55primitive streak formation (GO:0090009)4.16486329
56regulation of translation in response to stress (GO:0043555)4.16201438
57interferon-gamma production (GO:0032609)4.13757453
58T cell selection (GO:0045058)4.09456600
59cellular response to interleukin-15 (GO:0071350)4.07309941
60phenol-containing compound catabolic process (GO:0019336)4.07254817
61histone H4-K16 acetylation (GO:0043984)4.04798014
62cell fate commitment involved in formation of primary germ layer (GO:0060795)4.00303833
63regulation of telomerase activity (GO:0051972)3.95222597
64chromatin assembly (GO:0031497)3.92827058
65antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.91372428
66positive T cell selection (GO:0043368)3.89894026
67leukocyte aggregation (GO:0070486)3.89841987
68regulation of telomere maintenance (GO:0032204)3.88683339
69branching involved in mammary gland duct morphogenesis (GO:0060444)3.83981489
70protein deneddylation (GO:0000338)3.83566848
71nuclear pore complex assembly (GO:0051292)3.82778624
72maintenance of protein localization in organelle (GO:0072595)3.80812233
73coenzyme catabolic process (GO:0009109)3.77774170
74regulation of isotype switching to IgG isotypes (GO:0048302)3.77635827
75regulation of B cell differentiation (GO:0045577)3.73942425
76negative regulation of T cell mediated immunity (GO:0002710)3.71735353
77Arp2/3 complex-mediated actin nucleation (GO:0034314)3.69906556
78cardiovascular system development (GO:0072358)3.69425085
79GDP-mannose metabolic process (GO:0019673)3.66133512
80positive regulation of protein deacetylation (GO:0090312)3.64706588
81regulation of gamma-delta T cell differentiation (GO:0045586)3.60494572
82antigen receptor-mediated signaling pathway (GO:0050851)3.60177114
83regulation of defense response to virus by virus (GO:0050690)3.59397640
84protein polyglutamylation (GO:0018095)3.58065419
85T cell migration (GO:0072678)3.57737139
86neutrophil activation involved in immune response (GO:0002283)3.56402701
87mitochondrion distribution (GO:0048311)3.51563841
88DNA damage response, detection of DNA damage (GO:0042769)3.51244291
89DNA unwinding involved in DNA replication (GO:0006268)3.51183412
90B cell receptor signaling pathway (GO:0050853)3.50707297
91pseudouridine synthesis (GO:0001522)3.50648287
92hormone catabolic process (GO:0042447)3.50378167
93ribosome biogenesis (GO:0042254)3.49133854
94regulation of gamma-delta T cell activation (GO:0046643)3.48866964
95T cell receptor signaling pathway (GO:0050852)3.47966544
96nucleoside transport (GO:0015858)3.46339200
97negative regulation of lymphocyte mediated immunity (GO:0002707)3.40264958
98RNA stabilization (GO:0043489)3.37515787
99mRNA stabilization (GO:0048255)3.37515787
100histone H3-K9 modification (GO:0061647)3.34497819
101intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.31980492
102activated T cell proliferation (GO:0050798)3.31015473
103nuclear pore organization (GO:0006999)3.30140992
104antigen processing and presentation of endogenous antigen (GO:0019883)3.29005376
105regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.28934836
106formation of translation preinitiation complex (GO:0001731)3.27697907
107negative regulation of leukocyte mediated immunity (GO:0002704)3.27095570
108intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.25948379
109regulation of double-strand break repair (GO:2000779)3.25789627
110apoptotic DNA fragmentation (GO:0006309)3.25440530
111regulation of interleukin-2 biosynthetic process (GO:0045076)3.23299967
112DNA duplex unwinding (GO:0032508)3.22900475
113detection of temperature stimulus (GO:0016048)3.22487736
114negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.22074942
115antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.21858670
116leukocyte degranulation (GO:0043299)3.20483958
117positive regulation of granulocyte differentiation (GO:0030854)3.19197973
118DNA geometric change (GO:0032392)3.17687741
119microtubule severing (GO:0051013)3.17065703
120negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.13688629
121transcription from mitochondrial promoter (GO:0006390)3.11728614
122tachykinin receptor signaling pathway (GO:0007217)3.10742740
123retinoic acid receptor signaling pathway (GO:0048384)3.10341047
124DNA replication initiation (GO:0006270)3.09317511
125regulation of microtubule-based movement (GO:0060632)3.07655037
126negative regulation of T-helper cell differentiation (GO:0045623)3.06269618
127negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.06269618
128hypothalamus development (GO:0021854)3.05627600
129regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.04706012
130regulation of type I interferon-mediated signaling pathway (GO:0060338)3.02915874
131mitochondrial DNA replication (GO:0006264)3.01774853
132pore complex assembly (GO:0046931)3.00424967
133negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.00062650
134negative regulation of interleukin-2 production (GO:0032703)2.98643258
135maternal placenta development (GO:0001893)2.97847895
136proline transport (GO:0015824)2.97292503
137calcium-mediated signaling using intracellular calcium source (GO:0035584)2.96880348
138regulation of alpha-beta T cell proliferation (GO:0046640)2.96827628
139mast cell activation (GO:0045576)2.96817292
140negative regulation of glycoprotein biosynthetic process (GO:0010561)2.96108860
141regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.95716501
142regulation of DNA-dependent DNA replication (GO:0090329)2.95417609
143response to muramyl dipeptide (GO:0032495)2.94181230
144bone trabecula formation (GO:0060346)2.92523593
145positive regulation of histone deacetylation (GO:0031065)2.91747670
146negative regulation of bone resorption (GO:0045779)2.91690621
147phagocytosis, recognition (GO:0006910)2.90012316
148type I interferon signaling pathway (GO:0060337)2.88634358
149cellular response to type I interferon (GO:0071357)2.88634358
150positive regulation of alpha-beta T cell proliferation (GO:0046641)2.88283312
151T cell homeostasis (GO:0043029)2.88082649
152histone H3-K9 methylation (GO:0051567)2.84513341
153positive regulation of digestive system process (GO:0060456)2.83987635
154response to type I interferon (GO:0034340)2.83251602
155positive regulation of interleukin-2 production (GO:0032743)2.83054937
156negative regulation of interleukin-12 production (GO:0032695)2.82187389
157tolerance induction (GO:0002507)2.80747094
158negative regulation of phagocytosis (GO:0050765)2.80159649
159positive regulation of interleukin-4 production (GO:0032753)2.79448169
160actin nucleation (GO:0045010)2.78346429
161regulation of interleukin-4 production (GO:0032673)2.76219769
162antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.74259505
163histone H3-K4 trimethylation (GO:0080182)2.73117447
164negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.72750203
165T cell proliferation (GO:0042098)2.68924711
166purinergic nucleotide receptor signaling pathway (GO:0035590)2.68815005
167negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.68731229
168G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.67923058
169megakaryocyte development (GO:0035855)2.64549442
170negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.64351605
171detection of bacterium (GO:0016045)2.62887329
172positive regulation of isotype switching (GO:0045830)2.62658415
173mannose metabolic process (GO:0006013)2.62539727
174T cell costimulation (GO:0031295)2.61554285
175cellular extravasation (GO:0045123)2.60196199
176mast cell activation involved in immune response (GO:0002279)2.59491480
177mast cell degranulation (GO:0043303)2.59491480
178negative regulation of adaptive immune response (GO:0002820)2.59064853
179histone H3-K36 demethylation (GO:0070544)2.58295115
180lymphocyte costimulation (GO:0031294)2.57560862
181regulation of regulatory T cell differentiation (GO:0045589)2.56834877
182detection of other organism (GO:0098543)2.53782489
183histone H4 deacetylation (GO:0070933)2.52903751
184regulation of granulocyte differentiation (GO:0030852)2.52764775
185positive regulation of interleukin-1 beta secretion (GO:0050718)2.51806964
186immune response-activating cell surface receptor signaling pathway (GO:0002429)2.51710874
187positive regulation of steroid hormone secretion (GO:2000833)2.51594161
188regulation of histone H3-K27 methylation (GO:0061085)2.50370206
189neutrophil activation (GO:0042119)2.49437613
190poly(A)+ mRNA export from nucleus (GO:0016973)2.49329456
191positive regulation by symbiont of host defense response (GO:0052509)2.47795890
192modulation by symbiont of host defense response (GO:0052031)2.47795890
193modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.47795890
194positive regulation by organism of defense response of other organism involved in symbiotic interact2.47795890
195modulation by symbiont of host immune response (GO:0052553)2.47795890
196daunorubicin metabolic process (GO:0044597)11.3026349
197polyketide metabolic process (GO:0030638)11.3026349
198doxorubicin metabolic process (GO:0044598)11.3026349

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.10248816
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.10248816
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.10248816
4BP1_19119308_ChIP-ChIP_Hs578T_Human5.92134919
5E2F7_22180533_ChIP-Seq_HELA_Human5.29288059
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.85684462
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.75628142
8VDR_21846776_ChIP-Seq_THP-1_Human3.43063068
9IRF8_22096565_ChIP-ChIP_GC-B_Human3.30503110
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.28144794
11NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.06023542
12TP63_19390658_ChIP-ChIP_HaCaT_Human3.03609779
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.99526346
14RUNX_20019798_ChIP-Seq_JUKART_Human2.90040080
15POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.82487959
16MAF_26560356_Chip-Seq_TH1_Human2.77354438
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.72936272
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.71060984
19SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.68119338
20UTX_26944678_Chip-Seq_JUKART_Human2.65209702
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.60862228
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.60261053
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.59589241
24* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.55082543
25MYB_26560356_Chip-Seq_TH2_Human2.52192045
26MAF_26560356_Chip-Seq_TH2_Human2.48271836
27MYB_26560356_Chip-Seq_TH1_Human2.45955474
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.36658590
29KDM2B_26808549_Chip-Seq_DND41_Human2.32743443
30* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.30878211
31TCF3_18692474_ChIP-Seq_MESCs_Mouse2.29254687
32* SPI1_23547873_ChIP-Seq_NB4_Human2.25697132
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.24946894
34SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.24919749
35MYC_18555785_ChIP-Seq_MESCs_Mouse2.24376646
36TCF3_18692474_ChIP-Seq_MEFs_Mouse2.22966134
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.22925833
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.20783766
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.20611253
40VDR_24763502_ChIP-Seq_THP-1_Human2.19613921
41STAT4_19710469_ChIP-ChIP_TH1__Mouse2.10656599
42SPI1_23127762_ChIP-Seq_K562_Human2.06974905
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.06579063
44IRF1_19129219_ChIP-ChIP_H3396_Human2.04655229
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.03378621
46IRF8_21731497_ChIP-ChIP_J774_Mouse2.01685326
47ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.97884870
48NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.94899773
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.94284643
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.93954325
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.92209376
52RUNX1_22412390_ChIP-Seq_EML_Mouse1.91363167
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.88652481
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.85992924
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.84295709
56FOXM1_23109430_ChIP-Seq_U2OS_Human1.83770597
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80438142
58GATA3_27048872_Chip-Seq_THYMUS_Human1.80203035
59IRF8_27001747_Chip-Seq_BMDM_Mouse1.79088084
60NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79029813
61TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.78354237
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.77580985
63MYC_19030024_ChIP-ChIP_MESCs_Mouse1.76656309
64KDM2B_26808549_Chip-Seq_JURKAT_Human1.76023443
65NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.74872705
66SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74383422
67CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73638864
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.72484363
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.70635351
70* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.67509779
71GATA1_19941827_ChIP-Seq_MEL_Mouse1.67136090
72MYC_18358816_ChIP-ChIP_MESCs_Mouse1.65008841
73YY1_21170310_ChIP-Seq_MESCs_Mouse1.64240402
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59366646
75MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.58460114
76NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.57359340
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.56653559
78MYC_22102868_ChIP-Seq_BL_Human1.55110627
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54899158
80POU5F1_16518401_ChIP-PET_MESCs_Mouse1.52456872
81BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52113762
82NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50548408
83SOX2_18555785_ChIP-Seq_MESCs_Mouse1.50270969
84KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.49138829
85EZH2_22144423_ChIP-Seq_EOC_Human1.48342919
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48174382
87MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.48117524
88TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47454638
89ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.42504485
90LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.41484620
91LXR_22292898_ChIP-Seq_THP-1_Human1.40685658
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39602271
93HIF1A_21447827_ChIP-Seq_MCF-7_Human1.39399980
94STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39126660
95* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.38327082
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37854971
97CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37550215
98GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36931090
99* BCL6_27268052_Chip-Seq_Bcells_Human1.36828306
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36772088
101ELK3_25401928_ChIP-Seq_HUVEC_Human1.35784238
102POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.34254430
103P68_20966046_ChIP-Seq_HELA_Human1.34097530
104CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34020048
105SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33878709
106ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33613941
107GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33140199
108NANOG_18692474_ChIP-Seq_MEFs_Mouse1.32204110
109E2F1_17053090_ChIP-ChIP_MCF-7_Human1.31477197
110EST1_17652178_ChIP-ChIP_JURKAT_Human1.30974298
111LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30586296
112CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30088949
113NANOG_18692474_ChIP-Seq_MESCs_Mouse1.29958475
114* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.29865987
115TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28572065
116SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28002822
117RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23059217
118OCT4_18692474_ChIP-Seq_MEFs_Mouse1.20270373
119EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20119452
120NOTCH1_21737748_ChIP-Seq_TLL_Human1.18644449
121GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17684456
122PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17668808
123SOX2_18692474_ChIP-Seq_MESCs_Mouse1.17086516
124ELF1_20517297_ChIP-Seq_JURKAT_Human1.16115002
125* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.15886992
126PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15479738
127ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15286769
128SOX2_18692474_ChIP-Seq_MEFs_Mouse1.13958620
129CTCF_21964334_ChIP-Seq_BJAB-B_Human1.09771823
130SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.08074197
131CDX2_20551321_ChIP-Seq_CACO-2_Human1.07629170
132NANOG_16153702_ChIP-ChIP_HESCs_Human1.07343772
133SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07154942
134PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06823349
135SCL_19346495_ChIP-Seq_HPC-7_Human1.06752204
136* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06594405
137* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06439120
138GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06209715
139CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04260252
140SPI1_20517297_ChIP-Seq_HL60_Human1.02443407
141JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.02315823
142FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02027245
143ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01233694
144NANOG_21062744_ChIP-ChIP_HESCs_Human0.99756296
145NANOG_16518401_ChIP-PET_MESCs_Mouse0.99393757
146XRN2_22483619_ChIP-Seq_HELA_Human0.98736614
147KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98006182
148BCOR_27268052_Chip-Seq_Bcells_Human0.97858116
149TP53_22127205_ChIP-Seq_IMR90_Human0.96758943
150CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96512943
151* FOXP3_21729870_ChIP-Seq_TREG_Human0.96025515
152GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95273602
153EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95269623
154PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93661568
155CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93423714
156SA1_27219007_Chip-Seq_ERYTHROID_Human0.93393420
157ELK4_26923725_Chip-Seq_MESODERM_Mouse0.93145567
158HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.92982201
159ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92835808
160GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92747924
161CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92492332
162POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90834390
163SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90576212
164GATA3_26560356_Chip-Seq_TH2_Human0.88290804
165KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.87405947
166POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.87023460
167YY1_22570637_ChIP-Seq_MALME-3M_Human0.86736332
168ETS1_20019798_ChIP-Seq_JURKAT_Human0.86720687
169NCOR1_26117541_ChIP-Seq_K562_Human0.85483455
170SOX2_16153702_ChIP-ChIP_HESCs_Human0.84471256
171TCF7_22412390_ChIP-Seq_EML_Mouse0.84418819
172KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83007691
173NELFA_20434984_ChIP-Seq_ESCs_Mouse0.82025799
174KDM5A_27292631_Chip-Seq_BREAST_Human0.80255891
175SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.78097187
176HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.77623689
177E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.77192782
178KDM2B_26808549_Chip-Seq_SUP-B15_Human0.76939020
179CIITA_25753668_ChIP-Seq_RAJI_Human0.76922734
180SRY_22984422_ChIP-ChIP_TESTIS_Rat0.76566687
181GABP_19822575_ChIP-Seq_HepG2_Human0.75725905
182ESR1_15608294_ChIP-ChIP_MCF-7_Human0.75300580
183* TTF2_22483619_ChIP-Seq_HELA_Human0.75114797
184MYCN_18555785_ChIP-Seq_MESCs_Mouse0.74641387
185THAP11_20581084_ChIP-Seq_MESCs_Mouse0.73956853
186IGF1R_20145208_ChIP-Seq_DFB_Human0.72790376
187ZFX_18555785_ChIP-Seq_MESCs_Mouse0.72652659
188PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.71091926
189TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.70609553

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.64470040
2MP0003011_delayed_dark_adaptation4.31806498
3MP0002254_reproductive_system_inflammat4.08097703
4MP0004264_abnormal_extraembryonic_tissu4.04207177
5MP0005075_abnormal_melanosome_morpholog3.77711697
6MP0004858_abnormal_nervous_system3.53077146
7MP0005394_taste/olfaction_phenotype3.44168862
8MP0005499_abnormal_olfactory_system3.44168862
9MP0008057_abnormal_DNA_replication3.41382657
10MP0003890_abnormal_embryonic-extraembry3.40707969
11MP0003763_abnormal_thymus_physiology3.30513113
12MP0003122_maternal_imprinting3.23815098
13MP0004957_abnormal_blastocyst_morpholog2.89119324
14MP0005671_abnormal_response_to2.87986260
15MP0003436_decreased_susceptibility_to2.75387335
16MP0008877_abnormal_DNA_methylation2.73181690
17MP0005464_abnormal_platelet_physiology2.66809547
18MP0009278_abnormal_bone_marrow2.59983776
19MP0001800_abnormal_humoral_immune2.59012788
20MP0001835_abnormal_antigen_presentation2.58120393
21MP0003121_genomic_imprinting2.53389270
22MP0002332_abnormal_exercise_endurance2.49067621
23MP0002398_abnormal_bone_marrow2.35248898
24MP0002009_preneoplasia2.32076322
25MP0002653_abnormal_ependyma_morphology2.29615018
26MP0003183_abnormal_peptide_metabolism2.27916798
27MP0002723_abnormal_immune_serum2.27710106
28MP0005000_abnormal_immune_tolerance2.27297313
29MP0006035_abnormal_mitochondrial_morpho2.27008558
30MP0002420_abnormal_adaptive_immunity2.23610403
31MP0003303_peritoneal_inflammation2.22241005
32MP0001819_abnormal_immune_cell2.22126629
33MP0000703_abnormal_thymus_morphology2.20005438
34MP0000678_abnormal_parathyroid_gland2.12188054
35MP0005025_abnormal_response_to2.05031374
36MP0002452_abnormal_antigen_presenting2.00796161
37MP0003938_abnormal_ear_development2.00224615
38MP0000716_abnormal_immune_system1.96214543
39MP0005257_abnormal_intraocular_pressure1.93661900
40MP0003724_increased_susceptibility_to1.93655785
41MP0000689_abnormal_spleen_morphology1.92223528
42MP0004859_abnormal_synaptic_plasticity1.87169653
43MP0010030_abnormal_orbit_morphology1.87039324
44MP0000015_abnormal_ear_pigmentation1.82501068
45MP0010352_gastrointestinal_tract_polyps1.80899991
46MP0002722_abnormal_immune_system1.80135789
47MP0005397_hematopoietic_system_phenotyp1.79329579
48MP0001545_abnormal_hematopoietic_system1.79329579
49MP0001790_abnormal_immune_system1.78774505
50MP0005387_immune_system_phenotype1.78774505
51MP0005380_embryogenesis_phenotype1.77508199
52MP0001672_abnormal_embryogenesis/_devel1.77508199
53MP0002405_respiratory_system_inflammati1.76718561
54MP0008789_abnormal_olfactory_epithelium1.74320703
55MP0002419_abnormal_innate_immunity1.68843081
56MP0000049_abnormal_middle_ear1.66938203
57MP0002429_abnormal_blood_cell1.66697838
58MP0002088_abnormal_embryonic_growth/wei1.63850227
59MP0008260_abnormal_autophagy1.63728400
60MP0003984_embryonic_growth_retardation1.62890644
61MP0003077_abnormal_cell_cycle1.58092439
62MP0002396_abnormal_hematopoietic_system1.57548106
63MP0004947_skin_inflammation1.56687687
64MP0000350_abnormal_cell_proliferation1.56592441
65MP0001986_abnormal_taste_sensitivity1.54810265
66MP0005058_abnormal_lysosome_morphology1.54719413
67MP0009333_abnormal_splenocyte_physiolog1.52808816
68MP0000685_abnormal_immune_system1.52087551
69MP0003123_paternal_imprinting1.50949480
70MP0002127_abnormal_cardiovascular_syste1.47686475
71MP0005310_abnormal_salivary_gland1.45871556
72MP0002751_abnormal_autonomic_nervous1.43143641
73MP0001293_anophthalmia1.40563998
74MP0003705_abnormal_hypodermis_morpholog1.37297094
75MP0003866_abnormal_defecation1.36364587
76MP0003111_abnormal_nucleus_morphology1.35947490
77MP0008961_abnormal_basal_metabolism1.35010829
78MP0001849_ear_inflammation1.32975067
79MP0004808_abnormal_hematopoietic_stem1.32083293
80MP0002166_altered_tumor_susceptibility1.32015528
81MP0002277_abnormal_respiratory_mucosa1.31541192
82MP0009785_altered_susceptibility_to1.30494727
83MP0010094_abnormal_chromosome_stability1.29822790
84MP0004133_heterotaxia1.29714032
85MP0008932_abnormal_embryonic_tissue1.28323033
86MP0002932_abnormal_joint_morphology1.28321251
87MP0001873_stomach_inflammation1.27755747
88MP0002085_abnormal_embryonic_tissue1.26375488
89MP0002822_catalepsy1.24488317
90MP0000762_abnormal_tongue_morphology1.23792642
91MP0005266_abnormal_metabolism1.19863527
92MP0003300_gastrointestinal_ulcer1.19742525
93MP0002086_abnormal_extraembryonic_tissu1.18792390
94MP0002092_abnormal_eye_morphology1.18019482
95MP0000490_abnormal_crypts_of1.17824881
96MP0010155_abnormal_intestine_physiology1.16953291
97MP0000465_gastrointestinal_hemorrhage1.15303793
98MP0001348_abnormal_lacrimal_gland1.13967998
99MP0002114_abnormal_axial_skeleton1.13152433
100MP0002233_abnormal_nose_morphology1.12770173
101MP0000569_abnormal_digit_pigmentation1.12257944
102MP0001845_abnormal_inflammatory_respons1.11602862
103MP0002084_abnormal_developmental_patter1.09807734
104MP0008007_abnormal_cellular_replicative1.09654600
105MP0000428_abnormal_craniofacial_morphol1.09014622
106MP0000313_abnormal_cell_death1.05286564
107MP0003119_abnormal_digestive_system1.04842486
108MP0003787_abnormal_imprinting1.03735777
109MP0001533_abnormal_skeleton_physiology0.99502988
110MP0004043_abnormal_pH_regulation0.97700483
111MP0003137_abnormal_impulse_conducting0.96970849
112MP0001663_abnormal_digestive_system0.96612559
113MP0003283_abnormal_digestive_organ0.95668388
114MP0004197_abnormal_fetal_growth/weight/0.95048401
115MP0003315_abnormal_perineum_morphology0.94866216
116MP0000432_abnormal_head_morphology0.94542827
117MP0009379_abnormal_foot_pigmentation0.93504238
118MP0006082_CNS_inflammation0.93186370
119MP0003690_abnormal_glial_cell0.92265863
120MP0003755_abnormal_palate_morphology0.91048979
121MP0003136_yellow_coat_color0.90773151
122MP0008569_lethality_at_weaning0.89868199
123MP0003935_abnormal_craniofacial_develop0.89841575
124MP0002970_abnormal_white_adipose0.89386804
125MP0003635_abnormal_synaptic_transmissio0.87417625
126MP0001697_abnormal_embryo_size0.86948398
127MP0002148_abnormal_hypersensitivity_rea0.86504520
128MP0001730_embryonic_growth_arrest0.86040744
129MP0006276_abnormal_autonomic_nervous0.85503945
130MP0008770_decreased_survivor_rate0.84623899
131MP0002132_abnormal_respiratory_system0.84155774
132MP0005391_vision/eye_phenotype0.83834762
133MP0002249_abnormal_larynx_morphology0.82340775
134MP0002080_prenatal_lethality0.81975946
135MP0002006_tumorigenesis0.79968614
136MP0005174_abnormal_tail_pigmentation0.79701645
137MP0003329_amyloid_beta_deposits0.78274994
138MP0002116_abnormal_craniofacial_bone0.77795055
139MP0003828_pulmonary_edema0.77388127
140MP0005508_abnormal_skeleton_morphology0.76683410
141MP0004381_abnormal_hair_follicle0.75070919
142MP0002925_abnormal_cardiovascular_devel0.74888813
143MP0000358_abnormal_cell_content/0.73932724
144MP0000750_abnormal_muscle_regeneration0.73909445
145MP0003693_abnormal_embryo_hatching0.72992867
146MP0002210_abnormal_sex_determination0.71382222
147MP0009703_decreased_birth_body0.71169959
148MP0002928_abnormal_bile_duct0.70741983
149MP0002081_perinatal_lethality0.69404631
150MP0000749_muscle_degeneration0.68856849
151MP0003861_abnormal_nervous_system0.68777041
152MP0002063_abnormal_learning/memory/cond0.68636912
153MP0002019_abnormal_tumor_incidence0.67522059
154MP0005645_abnormal_hypothalamus_physiol0.66366127
155MP0001929_abnormal_gametogenesis0.66348454
156MP0004142_abnormal_muscle_tone0.64798524
157MP0001286_abnormal_eye_development0.63636277
158MP0003878_abnormal_ear_physiology0.62839264
159MP0005377_hearing/vestibular/ear_phenot0.62839264
160MP0005423_abnormal_somatic_nervous0.62494554
161MP0005384_cellular_phenotype0.62456783
162MP0002083_premature_death0.62252457
163MP0001270_distended_abdomen0.61954933
164MP0001145_abnormal_male_reproductive0.61680057
165MP0005197_abnormal_uvea_morphology0.61258328
166MP0001919_abnormal_reproductive_system0.61193486
167MP0001970_abnormal_pain_threshold0.60415898
168MP0000858_altered_metastatic_potential0.60304411
169MP0003172_abnormal_lysosome_physiology0.59712186
170MP0002752_abnormal_somatic_nervous0.59625247
171MP0002064_seizures0.59399701
172MP0001851_eye_inflammation0.58441767
173MP0001502_abnormal_circadian_rhythm0.58159861
174MP0003786_premature_aging0.57979882
175MP0008058_abnormal_DNA_repair0.57797943
176MP0000631_abnormal_neuroendocrine_gland0.57229814
177MP0002229_neurodegeneration0.57045851
178MP0005248_abnormal_Harderian_gland0.56361265
179MP0004811_abnormal_neuron_physiology0.55720428
180MP0008469_abnormal_protein_level0.54269902

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)7.49060592
2Hypochromic microcytic anemia (HP:0004840)5.69411578
3Hepatoblastoma (HP:0002884)5.39844588
4Papilledema (HP:0001085)5.19452722
5Elevated erythrocyte sedimentation rate (HP:0003565)4.96566015
6Panhypogammaglobulinemia (HP:0003139)4.87707638
7Multiple enchondromatosis (HP:0005701)4.78467881
8Rib fusion (HP:0000902)4.71382786
9Abnormality of the lower motor neuron (HP:0002366)4.46515456
10Ependymoma (HP:0002888)4.28905769
11Autoimmune hemolytic anemia (HP:0001890)4.26559415
12Nephroblastoma (Wilms tumor) (HP:0002667)4.02430165
13Gastrointestinal infarctions (HP:0005244)3.93536483
14Neoplasm of striated muscle (HP:0009728)3.87655724
15Rhabdomyosarcoma (HP:0002859)3.87492551
16Chromosomal breakage induced by crosslinking agents (HP:0003221)3.83007872
17Embryonal renal neoplasm (HP:0011794)3.73734907
18Aplasia/Hypoplasia of the fovea (HP:0008060)3.65414789
19Hypoplasia of the fovea (HP:0007750)3.65414789
20Chronic obstructive pulmonary disease (HP:0006510)3.62285728
21Obstructive lung disease (HP:0006536)3.62285728
22Stomatitis (HP:0010280)3.49794692
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.47525479
24Prolonged bleeding time (HP:0003010)3.40523832
25Recurrent abscess formation (HP:0002722)3.34493553
26Chromsome breakage (HP:0040012)3.27444398
27Abnormality of the fingertips (HP:0001211)3.20482325
28Rectovaginal fistula (HP:0000143)3.17195954
29Rectal fistula (HP:0100590)3.17195954
30Reduced antithrombin III activity (HP:0001976)3.15983389
31Testicular atrophy (HP:0000029)3.13131150
32Abnormal lung lobation (HP:0002101)3.11577182
33Fused cervical vertebrae (HP:0002949)3.11093334
34Partial duplication of thumb phalanx (HP:0009944)3.05887592
35Recurrent bacterial skin infections (HP:0005406)3.04820959
36Amyotrophic lateral sclerosis (HP:0007354)3.04086840
37Abnormality of the astrocytes (HP:0100707)3.01177006
38Astrocytoma (HP:0009592)3.01177006
39Bifid tongue (HP:0010297)2.98271199
40T lymphocytopenia (HP:0005403)2.98165718
41Horizontal nystagmus (HP:0000666)2.97787548
42Ragged-red muscle fibers (HP:0003200)2.97377518
43Abnormality of the prostate (HP:0008775)2.96548386
44Meningitis (HP:0001287)2.92684210
45Abnormality of the salivary glands (HP:0010286)2.91655252
46Intestinal fistula (HP:0100819)2.87739515
47Recurrent fungal infections (HP:0002841)2.86629962
48Anomalous pulmonary venous return (HP:0010772)2.85328615
49Chest pain (HP:0100749)2.85217234
50Eczematoid dermatitis (HP:0000976)2.82671323
51Amaurosis fugax (HP:0100576)2.81542072
52Recurrent viral infections (HP:0004429)2.80002461
53Abnormality of the fovea (HP:0000493)2.77803006
54Slow saccadic eye movements (HP:0000514)2.75779238
55Hyperinsulinemic hypoglycemia (HP:0000825)2.72390488
56Trismus (HP:0000211)2.70176933
57Diplopia (HP:0000651)2.69406495
58Abnormality of binocular vision (HP:0011514)2.69406495
59Type I transferrin isoform profile (HP:0003642)2.67375381
60Generalized hypotonia (HP:0001290)2.66482139
61Aplasia/hypoplasia of the humerus (HP:0006507)2.64664825
62Partial duplication of the phalanx of hand (HP:0009999)2.64192016
63Vaginal fistula (HP:0004320)2.63985286
64Epistaxis (HP:0000421)2.61929948
65Myokymia (HP:0002411)2.57957071
66Abnormality of T cells (HP:0002843)2.57187882
67Myositis (HP:0100614)2.56913550
68Short humerus (HP:0005792)2.56491904
69Preauricular skin tag (HP:0000384)2.55808133
70Abnormality of chromosome segregation (HP:0002916)2.54579423
71Vasculitis (HP:0002633)2.54305755
72Absent rod-and cone-mediated responses on ERG (HP:0007688)2.52234902
73Pendular nystagmus (HP:0012043)2.50547597
74Large earlobe (HP:0009748)2.50476132
75Agammaglobulinemia (HP:0004432)2.50057684
76Recurrent cutaneous fungal infections (HP:0011370)2.49664306
77Chronic mucocutaneous candidiasis (HP:0002728)2.49664306
78Meckel diverticulum (HP:0002245)2.49350386
79Abnormality of T cell number (HP:0011839)2.49268243
80Sensory axonal neuropathy (HP:0003390)2.49002836
81Nasolacrimal duct obstruction (HP:0000579)2.46052474
82Personality changes (HP:0000751)2.45623854
83Mediastinal lymphadenopathy (HP:0100721)2.44769983
84Supernumerary spleens (HP:0009799)2.42231632
85Spontaneous hematomas (HP:0007420)2.41984716
86Progressive muscle weakness (HP:0003323)2.41398052
87Aplasia/Hypoplasia of the uvula (HP:0010293)2.40694233
88Gastrointestinal inflammation (HP:0004386)2.40529879
89Hypochromic anemia (HP:0001931)2.40428990
90Abnormality of the pulmonary veins (HP:0011718)2.39994948
91Short 5th finger (HP:0009237)2.37840898
92IgG deficiency (HP:0004315)2.35590608
93Scanning speech (HP:0002168)2.35334364
94Abnormality of the ileum (HP:0001549)2.35068991
95Atrophy/Degeneration involving motor neurons (HP:0007373)2.33995594
96Encephalitis (HP:0002383)2.33372364
97Tongue fasciculations (HP:0001308)2.33130011
98Severe combined immunodeficiency (HP:0004430)2.31223339
99Shawl scrotum (HP:0000049)2.31188128
100Aplasia/Hypoplasia of the macula (HP:0008059)2.29586614
101Hyperventilation (HP:0002883)2.28183562
102Recurrent skin infections (HP:0001581)2.28162942
103Impulsivity (HP:0100710)2.27188291
104Abnormality of macrophages (HP:0004311)2.26347551
105Colitis (HP:0002583)2.24681198
106Cellulitis (HP:0100658)2.24555465
107Periauricular skin pits (HP:0100277)2.23321530
108Preauricular pit (HP:0004467)2.23321530
109Malignant neoplasm of the central nervous system (HP:0100836)2.22645238
110Aplasia/Hypoplasia of the sternum (HP:0006714)2.22613446
111Inflammation of the large intestine (HP:0002037)2.22343400
112Skin tags (HP:0010609)2.22213685
113Missing ribs (HP:0000921)2.21714002
114Glioma (HP:0009733)2.21519006
115Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.21383675
116Basal cell carcinoma (HP:0002671)2.20339821
117Microretrognathia (HP:0000308)2.20107277
118Abnormal cartilage morphology (HP:0002763)2.19347014
119Spinal canal stenosis (HP:0003416)2.19042496
120Supranuclear gaze palsy (HP:0000605)2.18360742
121Abnormality of the phalanges of the hallux (HP:0010057)2.17382945
122Amblyopia (HP:0000646)2.16954542
123Medulloblastoma (HP:0002885)2.14976775
124Short middle phalanx of the 5th finger (HP:0004220)2.13885154
125Tented upper lip vermilion (HP:0010804)2.12311919
126Microvesicular hepatic steatosis (HP:0001414)2.12247567
127Acute hepatic failure (HP:0006554)2.11522882
128Hip dysplasia (HP:0001385)2.11225438
129Spondylolisthesis (HP:0003302)2.11224686
130Glossoptosis (HP:0000162)2.11068488
131Aplastic anemia (HP:0001915)2.09338054
132Long palpebral fissure (HP:0000637)2.07398132
133Duodenal stenosis (HP:0100867)2.06707836
134Small intestinal stenosis (HP:0012848)2.06707836
135Abnormality of glycolipid metabolism (HP:0010969)2.06549810
136Abnormality of liposaccharide metabolism (HP:0010968)2.06549810
137Abnormality of glycosphingolipid metabolism (HP:0004343)2.06549810
138Abnormality of saccadic eye movements (HP:0000570)2.06373272
139Aplasia/Hypoplasia affecting the retina (HP:0008061)2.06069995
140Renal duplication (HP:0000075)2.06051455
141Thrombocytosis (HP:0001894)2.05683876
142Abnormality of small intestinal villus morphology (HP:0011472)2.05464693
143Villous atrophy (HP:0011473)2.05464693
144Muscle fibrillation (HP:0010546)2.04532246
145Granulocytopenia (HP:0001913)2.04517319
146Neoplasm of the heart (HP:0100544)2.04500029
147Arterial thrombosis (HP:0004420)2.03382734
148Urinary bladder sphincter dysfunction (HP:0002839)2.02712026
149Tetraplegia (HP:0002445)2.02331567
150Supernumerary nipples (HP:0002558)2.00881266
151Menstrual irregularities (HP:0000858)2.00201404
152Increased IgM level (HP:0003496)1.99018240
153Embryonal neoplasm (HP:0002898)1.98453883
154Abnormality of T cell physiology (HP:0011840)1.98323978
155Abnormality of the musculature of the hand (HP:0001421)1.97229381
156Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.96809985
157Broad alveolar ridges (HP:0000187)1.96641973
158Pseudobulbar signs (HP:0002200)1.96324551
159Cheilitis (HP:0100825)1.95843668
160Aplasia/Hypoplasia of the thymus (HP:0010515)1.94863859
161Pustule (HP:0200039)1.94225777
1623-Methylglutaconic aciduria (HP:0003535)1.94101508
163Petechiae (HP:0000967)1.92197786
164Abnormality of the distal phalanx of the thumb (HP:0009617)1.89229591
165Abnormality of male internal genitalia (HP:0000022)1.87958681
166Neuroblastoma (HP:0003006)1.87060629
167Primitive neuroectodermal tumor (HP:0030065)1.87060629
168Neuroblastic tumors (HP:0004376)1.87060629
169Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.87060629
170Thickened calvaria (HP:0002684)1.86679292
171Lymphopenia (HP:0001888)1.86095631
172Combined immunodeficiency (HP:0005387)1.85619115
173Self-mutilation (HP:0000742)1.84301880
174Ankyloglossia (HP:0010296)1.81424840
175Degeneration of the lateral corticospinal tracts (HP:0002314)1.79598191
176Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79598191
177Leukocytosis (HP:0001974)1.77220946
178B lymphocytopenia (HP:0010976)1.76941129
179Abnormality of lateral ventricle (HP:0030047)1.75810119
180Abnormal platelet volume (HP:0011876)1.75761334
181Upper motor neuron abnormality (HP:0002127)1.74956719
182Pulmonary fibrosis (HP:0002206)1.74412497
183Abnormality of the thymus (HP:0000777)1.74130640
184Recurrent sinusitis (HP:0011108)1.72103904
185Abnormality of oral frenula (HP:0000190)1.71746205
186Acute lymphatic leukemia (HP:0006721)1.71120446
187Ureteral stenosis (HP:0000071)1.70045169
188Disinhibition (HP:0000734)1.69457379
189Episodic fever (HP:0001954)1.69153493
190Annular pancreas (HP:0001734)1.69096772
191Thoracolumbar scoliosis (HP:0002944)1.67652111
192Increased IgE level (HP:0003212)1.67441329
193Pulmonary embolism (HP:0002204)1.65751340
194Hemoptysis (HP:0002105)1.64163151
195Orchitis (HP:0100796)1.63439788
196Metaphyseal cupping (HP:0003021)1.63322613

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.94476085
2GRK55.34036913
3RIPK44.57639393
4MAP4K14.37848438
5GRK64.35822520
6ERN14.32418223
7TXK3.31222110
8ADRBK23.16171710
9CSF1R2.98256390
10GRK12.90159586
11JAK32.66408938
12FES2.62768951
13MATK2.60269829
14BTK2.58863487
15TTK2.51148929
16TGFBR22.51017384
17GRK72.47658076
18TEC2.45707577
19MAPK72.44985824
20TYRO32.36961619
21STK102.16098511
22MOS1.97082106
23TYK21.96246198
24TNK21.92631745
25WNK11.88435882
26SYK1.86769426
27CDK71.78053491
28NTRK11.77056683
29SIK21.76817733
30HCK1.58565233
31LCK1.54212887
32BLK1.53161279
33CAMK41.52400669
34PRKG21.48589031
35HIPK21.48568010
36PRKD31.41488726
37CDC71.37604185
38LYN1.34271314
39MARK21.33417539
40CHEK21.33189166
41PAK41.29333875
42MAP4K21.25877743
43TRIB31.24546369
44TESK21.22384410
45ZAP701.19756302
46MAP2K41.16816449
47AKT31.15492910
48ADRBK11.14808629
49EPHA21.14487598
50PLK11.12999341
51EIF2AK21.11486655
52MAP2K31.09873402
53IKBKE1.08702839
54TAOK31.06709431
55JAK11.05479123
56CAMKK10.98329231
57SMG10.97845211
58MAP3K40.96556280
59EIF2AK30.91029823
60MAP3K130.89437881
61SGK30.89430920
62FYN0.86970137
63IRAK40.86728527
64SGK20.85460151
65BRD40.85418036
66WEE10.84232984
67FGFR30.82935068
68MAP2K60.82502097
69EIF2AK10.80857318
70JAK20.79128704
71AKT20.78262900
72TBK10.76703652
73CDK30.75234235
74PASK0.74758768
75MAP3K100.74499195
76CHEK10.74219391
77SIK10.72348256
78RET0.71036716
79MAPK120.70873108
80EEF2K0.69491302
81PRKCH0.68783210
82PKN20.67365276
83AURKA0.64848985
84MAP3K110.64599387
85CDK190.64384908
86LRRK20.64011917
87STK110.63495695
88CDK80.62681163
89ALK0.62281019
90CDK90.61286256
91BUB10.61000841
92PRPF4B0.60966688
93MARK30.56731148
94FGFR40.56542388
95BMPR20.54418726
96NEK20.54233219
97PDK10.54102219
98DYRK20.52655425
99NLK0.52486414
100RPS6KB20.52343327
101SGK4940.51885848
102SGK2230.51885848
103MAP3K60.51769676
104CDK20.50650733
105MAP2K70.49625070
106DYRK1A0.48979876
107BMX0.47728348
108TAOK10.46308745
109MAPKAPK30.45802767
110PAK10.45467335
111MAP3K140.45426053
112MAP3K70.45396621
113PTK60.44463060
114PRKCI0.44369554
115STK240.44140447
116BCKDK0.43119626
117CSK0.42099784
118NTRK30.41137441
119SIK30.40474174
120SRPK10.40450033
121DYRK30.39925523
122YES10.39866443
123FGR0.39369040
124MAPK130.38243665
125CAMK10.38107166
126CDK40.38030620
127KSR20.37486087
128UHMK10.36743264
129PIM20.35324465
130LATS20.33890910
131CDK180.33755080
132PRKCD0.33482418
133FGFR20.33260465
134CDK150.33194499
135CDK11A0.33136830
136MTOR0.31987453
137MAPK40.30488969
138CSNK1E0.28934049
139TAOK20.28683522
140IGF1R0.28652975
141ATM0.28352830
142ITK0.26592072
143AURKB0.26168374
144CDK10.25930592
145CDK140.25732968
146MKNK10.25512656
147NTRK20.25449662
148MAP3K90.23906751
149NEK10.22292649
150MAPK100.21651985
151PTK20.21328184
152MAPK140.20878003
153GSK3B0.20712869
154ERBB20.19796756
155MAPK10.18631874
156DYRK1B0.18176484
157PRKD20.17820565
158KIT0.17407622
159MKNK20.16978489
160PRKCG0.16632129
161MAPKAPK20.15073532
162SCYL20.14026284
163PIM10.13077708
164IKBKB0.13064134
165ACVR1B0.12587714
166ATR0.11353596
167PRKACB0.11006336

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.79300639
2Vitamin B6 metabolism_Homo sapiens_hsa007505.34522983
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.22867754
4Fructose and mannose metabolism_Homo sapiens_hsa000513.52906910
5Primary immunodeficiency_Homo sapiens_hsa053403.04230186
6DNA replication_Homo sapiens_hsa030302.81713324
7Galactose metabolism_Homo sapiens_hsa000522.53048446
8T cell receptor signaling pathway_Homo sapiens_hsa046602.48084889
9Arachidonic acid metabolism_Homo sapiens_hsa005902.45677310
10B cell receptor signaling pathway_Homo sapiens_hsa046622.31555150
11Mismatch repair_Homo sapiens_hsa034302.23961971
12RNA transport_Homo sapiens_hsa030132.08497875
13Thyroid cancer_Homo sapiens_hsa052161.95031636
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.91692188
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.91378620
16Measles_Homo sapiens_hsa051621.87594907
17Hematopoietic cell lineage_Homo sapiens_hsa046401.80965137
18Ribosome_Homo sapiens_hsa030101.79834563
19Fanconi anemia pathway_Homo sapiens_hsa034601.78225155
20Cell cycle_Homo sapiens_hsa041101.77747581
21Osteoclast differentiation_Homo sapiens_hsa043801.74735755
22Homologous recombination_Homo sapiens_hsa034401.73040427
23Graft-versus-host disease_Homo sapiens_hsa053321.68027663
24mRNA surveillance pathway_Homo sapiens_hsa030151.67026891
25Linoleic acid metabolism_Homo sapiens_hsa005911.63605414
26Base excision repair_Homo sapiens_hsa034101.62257790
27Allograft rejection_Homo sapiens_hsa053301.60683027
28Spliceosome_Homo sapiens_hsa030401.60563338
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57538016
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.57356712
31Chemokine signaling pathway_Homo sapiens_hsa040621.53539604
32Leishmaniasis_Homo sapiens_hsa051401.50601066
33Autoimmune thyroid disease_Homo sapiens_hsa053201.49792255
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.49036839
35Platelet activation_Homo sapiens_hsa046111.48965572
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.44364125
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.44160882
38RNA degradation_Homo sapiens_hsa030181.42726604
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.32478585
40One carbon pool by folate_Homo sapiens_hsa006701.30559694
41Antigen processing and presentation_Homo sapiens_hsa046121.28170373
42Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.26162010
43mTOR signaling pathway_Homo sapiens_hsa041501.25030493
44Type I diabetes mellitus_Homo sapiens_hsa049401.23546625
45Other glycan degradation_Homo sapiens_hsa005111.21138397
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.21038757
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.20330610
48Transcriptional misregulation in cancer_Homo sapiens_hsa052021.18737618
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11278836
50Chronic myeloid leukemia_Homo sapiens_hsa052201.07853096
51p53 signaling pathway_Homo sapiens_hsa041151.07421366
52Hepatitis B_Homo sapiens_hsa051611.06901843
53Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05778536
54NF-kappa B signaling pathway_Homo sapiens_hsa040641.02934422
55Tuberculosis_Homo sapiens_hsa051521.02491602
56RNA polymerase_Homo sapiens_hsa030201.01669282
57Influenza A_Homo sapiens_hsa051641.01043030
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00575817
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.97958205
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95488967
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.95392481
62Viral myocarditis_Homo sapiens_hsa054160.94439539
63Dorso-ventral axis formation_Homo sapiens_hsa043200.93345543
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92584068
65Hepatitis C_Homo sapiens_hsa051600.91861981
66Ether lipid metabolism_Homo sapiens_hsa005650.90545652
67Basal transcription factors_Homo sapiens_hsa030220.89920374
68Endocytosis_Homo sapiens_hsa041440.87322392
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86136872
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86012160
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85486302
72Nucleotide excision repair_Homo sapiens_hsa034200.83839914
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83408655
74Shigellosis_Homo sapiens_hsa051310.83156562
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.83126411
76Pathways in cancer_Homo sapiens_hsa052000.80167373
77Pyrimidine metabolism_Homo sapiens_hsa002400.79279034
78Endometrial cancer_Homo sapiens_hsa052130.78192692
79Basal cell carcinoma_Homo sapiens_hsa052170.78088764
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77529533
81Inositol phosphate metabolism_Homo sapiens_hsa005620.76602765
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76536314
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75780766
84Prolactin signaling pathway_Homo sapiens_hsa049170.75509190
85MicroRNAs in cancer_Homo sapiens_hsa052060.75424672
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75282295
87Acute myeloid leukemia_Homo sapiens_hsa052210.75087456
88Pentose phosphate pathway_Homo sapiens_hsa000300.74401466
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73538606
90Glioma_Homo sapiens_hsa052140.73180557
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72645980
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72202990
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71263077
94Long-term potentiation_Homo sapiens_hsa047200.70911741
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70899557
96Morphine addiction_Homo sapiens_hsa050320.70487488
97Cholinergic synapse_Homo sapiens_hsa047250.70218846
98Toxoplasmosis_Homo sapiens_hsa051450.70192294
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69257474
100Hedgehog signaling pathway_Homo sapiens_hsa043400.68720504
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68685723
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67599365
103Ovarian steroidogenesis_Homo sapiens_hsa049130.65052503
104Non-small cell lung cancer_Homo sapiens_hsa052230.64502243
105Synaptic vesicle cycle_Homo sapiens_hsa047210.64490518
106Sulfur relay system_Homo sapiens_hsa041220.63384478
107Choline metabolism in cancer_Homo sapiens_hsa052310.62529612
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62128985
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61080513
110Phagosome_Homo sapiens_hsa041450.60732617
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59566711
112Non-homologous end-joining_Homo sapiens_hsa034500.59359545
113ErbB signaling pathway_Homo sapiens_hsa040120.59134344
114Dopaminergic synapse_Homo sapiens_hsa047280.58650120
115Notch signaling pathway_Homo sapiens_hsa043300.56645963
116MAPK signaling pathway_Homo sapiens_hsa040100.56238874
117Rap1 signaling pathway_Homo sapiens_hsa040150.55772801
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54137854
119Serotonergic synapse_Homo sapiens_hsa047260.53642050
120Herpes simplex infection_Homo sapiens_hsa051680.52630359
121Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52579674
122GnRH signaling pathway_Homo sapiens_hsa049120.51670812
123Estrogen signaling pathway_Homo sapiens_hsa049150.51501325
124Bladder cancer_Homo sapiens_hsa052190.50837091
125Type II diabetes mellitus_Homo sapiens_hsa049300.50624124
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50285181
127Epstein-Barr virus infection_Homo sapiens_hsa051690.50270249
128Wnt signaling pathway_Homo sapiens_hsa043100.49580294
129Colorectal cancer_Homo sapiens_hsa052100.46273130
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45127879
131Apoptosis_Homo sapiens_hsa042100.44839701
132Gap junction_Homo sapiens_hsa045400.44671613
133Hippo signaling pathway_Homo sapiens_hsa043900.42590607
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.37664010
135Taste transduction_Homo sapiens_hsa047420.37370663
136Folate biosynthesis_Homo sapiens_hsa007900.36445855
137Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36203283
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.35861144
139VEGF signaling pathway_Homo sapiens_hsa043700.34147769
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32822807
141Oocyte meiosis_Homo sapiens_hsa041140.32600595
142Renin-angiotensin system_Homo sapiens_hsa046140.31445841
143Long-term depression_Homo sapiens_hsa047300.31108516
144Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31094731
145African trypanosomiasis_Homo sapiens_hsa051430.30380782
146Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30125646
147Neurotrophin signaling pathway_Homo sapiens_hsa047220.30125134
148Pancreatic cancer_Homo sapiens_hsa052120.29729160
149Glutamatergic synapse_Homo sapiens_hsa047240.29612170
150Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28462478
151GABAergic synapse_Homo sapiens_hsa047270.25476700
152Ras signaling pathway_Homo sapiens_hsa040140.25181002
153HTLV-I infection_Homo sapiens_hsa051660.24637716
154Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24436495
155AMPK signaling pathway_Homo sapiens_hsa041520.24376313
156Viral carcinogenesis_Homo sapiens_hsa052030.23323568
157Leukocyte transendothelial migration_Homo sapiens_hsa046700.22727121
158Regulation of autophagy_Homo sapiens_hsa041400.22406680
159Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.20156336
160Proteoglycans in cancer_Homo sapiens_hsa052050.19440789
161Metabolic pathways_Homo sapiens_hsa011000.18344107

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