PCYT1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the cytidylyltransferase family and is involved in the regulation of phosphatidylcholine biosynthesis. Mutations in this gene are associated with spondylometaphyseal dysplasia with cone-rod dystrophy. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.98230979
2alpha-linolenic acid metabolic process (GO:0036109)4.58019661
3L-phenylalanine catabolic process (GO:0006559)4.43824391
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.43824391
5lysine metabolic process (GO:0006553)4.35660864
6lysine catabolic process (GO:0006554)4.35660864
7regulation of triglyceride catabolic process (GO:0010896)4.35344715
8fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.34100287
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.19382402
10L-phenylalanine metabolic process (GO:0006558)4.19382402
11protein carboxylation (GO:0018214)4.13706123
12peptidyl-glutamic acid carboxylation (GO:0017187)4.13706123
13regulation of sequestering of triglyceride (GO:0010889)4.10067233
14glyoxylate metabolic process (GO:0046487)4.06707840
15aromatic amino acid family catabolic process (GO:0009074)4.01794358
16urea metabolic process (GO:0019627)3.95256211
17urea cycle (GO:0000050)3.95256211
18plasma lipoprotein particle clearance (GO:0034381)3.89636344
19amino-acid betaine metabolic process (GO:0006577)3.87239635
20kynurenine metabolic process (GO:0070189)3.83510406
21positive regulation of fatty acid beta-oxidation (GO:0032000)3.80935557
22cysteine metabolic process (GO:0006534)3.76739910
23fatty acid beta-oxidation (GO:0006635)3.75798305
24complement activation, alternative pathway (GO:0006957)3.75768481
25phospholipid efflux (GO:0033700)3.73504832
26high-density lipoprotein particle remodeling (GO:0034375)3.72977795
27fatty acid transmembrane transport (GO:1902001)3.71148789
28sulfur amino acid catabolic process (GO:0000098)3.68169308
29positive regulation of lipid catabolic process (GO:0050996)3.67508620
30plasma lipoprotein particle assembly (GO:0034377)3.67097665
31low-density lipoprotein particle clearance (GO:0034383)3.66772107
32negative regulation of fibrinolysis (GO:0051918)3.64471431
33regulation of cholesterol homeostasis (GO:2000188)3.63717824
34indole-containing compound catabolic process (GO:0042436)3.63380210
35indolalkylamine catabolic process (GO:0046218)3.63380210
36tryptophan catabolic process (GO:0006569)3.63380210
37protein localization to endosome (GO:0036010)3.61761888
38phospholipid homeostasis (GO:0055091)3.59641030
39fatty acid oxidation (GO:0019395)3.58422061
40triglyceride homeostasis (GO:0070328)3.57469158
41acylglycerol homeostasis (GO:0055090)3.57469158
42homocysteine metabolic process (GO:0050667)3.56697337
43protein-lipid complex assembly (GO:0065005)3.56115833
44regulation of protein activation cascade (GO:2000257)3.55896521
45nitrogen cycle metabolic process (GO:0071941)3.55821050
46bile acid biosynthetic process (GO:0006699)3.53428608
47very-low-density lipoprotein particle assembly (GO:0034379)3.52861757
48lipid oxidation (GO:0034440)3.52373490
49plasma lipoprotein particle remodeling (GO:0034369)3.46220654
50protein-lipid complex remodeling (GO:0034368)3.46220654
51macromolecular complex remodeling (GO:0034367)3.46220654
52reverse cholesterol transport (GO:0043691)3.45565004
53tryptophan metabolic process (GO:0006568)3.42285631
54cholesterol efflux (GO:0033344)3.41992269
55carnitine shuttle (GO:0006853)3.41359724
56regulation of cholesterol esterification (GO:0010872)3.40983719
57fatty acid catabolic process (GO:0009062)3.40115825
58carnitine metabolic process (GO:0009437)3.39925441
59regulation of complement activation (GO:0030449)3.38668671
60positive regulation of fatty acid oxidation (GO:0046321)3.37961998
61regulation of fatty acid beta-oxidation (GO:0031998)3.36027156
622-oxoglutarate metabolic process (GO:0006103)3.31546711
63acetyl-CoA metabolic process (GO:0006084)3.30121275
64negative regulation of sterol transport (GO:0032372)3.29694351
65negative regulation of cholesterol transport (GO:0032375)3.29694351
66positive regulation of triglyceride lipase activity (GO:0061365)3.27789694
67positive regulation of lipoprotein lipase activity (GO:0051006)3.27789694
68short-chain fatty acid metabolic process (GO:0046459)3.26731966
69cellular ketone body metabolic process (GO:0046950)3.26364484
70antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.25561381
71regulation of fibrinolysis (GO:0051917)3.24155231
72cholesterol homeostasis (GO:0042632)3.22895777
73sterol homeostasis (GO:0055092)3.20485691
74positive regulation of lipid storage (GO:0010884)3.20193610
75monocarboxylic acid catabolic process (GO:0072329)3.15760241
76barbed-end actin filament capping (GO:0051016)3.15228555
77regulation of fatty acid oxidation (GO:0046320)3.15226569
78drug catabolic process (GO:0042737)3.14856098
79bile acid metabolic process (GO:0008206)3.13529607
80antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.12338058
81bile acid and bile salt transport (GO:0015721)3.10815706
82cellular glucuronidation (GO:0052695)3.10741808
83aspartate family amino acid catabolic process (GO:0009068)3.10471205
84ethanol oxidation (GO:0006069)3.09872740
85lipoprotein metabolic process (GO:0042157)3.07437687
86intestinal cholesterol absorption (GO:0030299)3.07374061
87plasma lipoprotein particle organization (GO:0071827)3.05774112
88regulation of cholesterol metabolic process (GO:0090181)3.05646791
89regulation of cholesterol storage (GO:0010885)3.05375871
90serine family amino acid catabolic process (GO:0009071)3.04535803
91flavonoid metabolic process (GO:0009812)3.03530559
92protein-lipid complex subunit organization (GO:0071825)3.03353923
93positive regulation of triglyceride metabolic process (GO:0090208)3.03259563
94epoxygenase P450 pathway (GO:0019373)2.99010807
95NADH metabolic process (GO:0006734)2.97310080
96modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.94935700
97positive regulation by organism of defense response of other organism involved in symbiotic interact2.94935700
98modulation by symbiont of host immune response (GO:0052553)2.94935700
99positive regulation by symbiont of host defense response (GO:0052509)2.94935700
100modulation by symbiont of host defense response (GO:0052031)2.94935700
101modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.94935700
102stress fiber assembly (GO:0043149)2.94721314
103hypotonic response (GO:0006971)2.94649425
104valine metabolic process (GO:0006573)2.94606370
105positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.94083985
106fibrinolysis (GO:0042730)2.92449075
107carnitine transmembrane transport (GO:1902603)2.92132199
108amino-acid betaine transport (GO:0015838)2.92071330
109carnitine transport (GO:0015879)2.92071330
110antigen processing and presentation of endogenous antigen (GO:0019883)2.91261985
111hemidesmosome assembly (GO:0031581)2.90898503
112desmosome organization (GO:0002934)2.89606322
113negative regulation of cell killing (GO:0031342)2.89562021
114negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.89562021
115skin morphogenesis (GO:0043589)2.87163848
116drug transmembrane transport (GO:0006855)2.86850990
117alpha-amino acid catabolic process (GO:1901606)2.86105704
118aromatic amino acid family metabolic process (GO:0009072)2.85919116
119cell-substrate junction assembly (GO:0007044)2.85178997
120negative regulation of protein localization to plasma membrane (GO:1903077)2.85044413
121positive regulation of Cdc42 GTPase activity (GO:0043089)2.83366649
122ketone body metabolic process (GO:1902224)2.83166795
123positive regulation of fatty acid metabolic process (GO:0045923)2.82751677
124macrophage activation involved in immune response (GO:0002281)2.79992135
125pinocytosis (GO:0006907)2.79988325
126response to peptidoglycan (GO:0032494)2.79155495
127positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.77773061
128positive regulation of receptor recycling (GO:0001921)2.77641680
129Golgi transport vesicle coating (GO:0048200)2.76632428
130COPI coating of Golgi vesicle (GO:0048205)2.76632428
131detection of molecule of bacterial origin (GO:0032490)2.75790936
132detection of other organism (GO:0098543)2.72747708
133positive regulation of gamma-delta T cell activation (GO:0046645)2.67928018
134negative regulation of erythrocyte differentiation (GO:0045647)2.65588939
135negative regulation of interleukin-12 production (GO:0032695)2.63630683
136antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.63016381
137cell adhesion mediated by integrin (GO:0033627)2.61413197
138positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.59101783
139regulation of T-helper 2 cell differentiation (GO:0045628)2.57264937
140regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.55984029
141germinal center formation (GO:0002467)2.55763661
142membrane raft organization (GO:0031579)2.54630869
143neutrophil activation involved in immune response (GO:0002283)2.54609566
144detection of external biotic stimulus (GO:0098581)2.53446869
145regulation of early endosome to late endosome transport (GO:2000641)2.49816832
146lipopolysaccharide-mediated signaling pathway (GO:0031663)2.49754606
147positive regulation of cellular amide metabolic process (GO:0034250)2.49057931
148detection of bacterium (GO:0016045)2.48270283
149regulation of interferon-beta biosynthetic process (GO:0045357)2.45347312
150positive regulation of extracellular matrix organization (GO:1903055)2.44028425
151response to laminar fluid shear stress (GO:0034616)2.41801089
152cellular extravasation (GO:0045123)2.41193731
153focal adhesion assembly (GO:0048041)2.41033311
154cell-substrate adherens junction assembly (GO:0007045)2.41033311
155glycosphingolipid catabolic process (GO:0046479)2.40571225
156endodermal cell differentiation (GO:0035987)2.40498908
157regulation of extracellular matrix disassembly (GO:0010715)2.38464750
158mannose metabolic process (GO:0006013)2.38322618
159regulation of necroptotic process (GO:0060544)2.36997880
160leukocyte aggregation (GO:0070486)2.35574300
161iron ion import (GO:0097286)2.35433109
162cellular response to thyroid hormone stimulus (GO:0097067)2.33110953
163negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.33033618
164positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.32595328
165regulation of macrophage cytokine production (GO:0010935)2.32376385
166positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.30352409
167apoptotic cell clearance (GO:0043277)2.29771630
168positive regulation of endothelial cell apoptotic process (GO:2000353)2.29178700
169embryonic process involved in female pregnancy (GO:0060136)2.27338497
170negative regulation of fatty acid transport (GO:2000192)2.26455051
171regulation of membrane protein ectodomain proteolysis (GO:0051043)2.25648514
172positive regulation of blood vessel endothelial cell migration (GO:0043536)2.24746412
173epithelial cell-cell adhesion (GO:0090136)2.23150587
174adherens junction assembly (GO:0034333)2.22555192
175regulation of gamma-delta T cell activation (GO:0046643)2.22161580
176cellular response to epinephrine stimulus (GO:0071872)2.21798766
177regulation of water loss via skin (GO:0033561)2.20864701
178response to muramyl dipeptide (GO:0032495)2.20203730
179production of molecular mediator involved in inflammatory response (GO:0002532)2.19964168
180epithelial cell differentiation involved in prostate gland development (GO:0060742)2.19520754
181response to vitamin D (GO:0033280)2.18738454
182regulation of leukocyte degranulation (GO:0043300)2.17963084
183regulation of type I interferon-mediated signaling pathway (GO:0060338)2.17545247
184glycolipid catabolic process (GO:0019377)2.16994321
185cortical actin cytoskeleton organization (GO:0030866)2.16097977
186JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.14237714
187response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.11463180
188response to host (GO:0075136)2.11463180
189response to host defenses (GO:0052200)2.11463180
190mammary gland epithelial cell proliferation (GO:0033598)2.10991338
191detection of biotic stimulus (GO:0009595)2.10460087
192muscle filament sliding (GO:0030049)2.08047620
193actin-myosin filament sliding (GO:0033275)2.08047620
194modulation by symbiont of host cellular process (GO:0044068)2.07818688
195membrane protein ectodomain proteolysis (GO:0006509)2.06770939
196regulation of dendritic cell antigen processing and presentation (GO:0002604)2.04892880
197positive regulation of leukocyte degranulation (GO:0043302)2.02262633
198basement membrane organization (GO:0071711)2.01585529
199regulation of gamma-delta T cell differentiation (GO:0045586)2.01447059

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.80776957
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.57955558
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.21590002
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.04878994
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.66969864
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.76112806
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.34514912
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.94005895
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.92609066
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.70282345
11CLOCK_20551151_ChIP-Seq_293T_Human2.49571630
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.26103401
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.19449355
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.16768717
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.12449211
16GATA1_22025678_ChIP-Seq_K562_Human2.10926507
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.01870838
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.98735329
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.98728269
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.94295665
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.83217164
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.78341955
23KDM2B_26808549_Chip-Seq_SUP-B15_Human1.78011293
24CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.75681760
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.75241267
26VDR_21846776_ChIP-Seq_THP-1_Human1.74914784
27TCF7_22412390_ChIP-Seq_EML_Mouse1.74032324
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66028267
29VDR_24763502_ChIP-Seq_THP-1_Human1.65133477
30STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.64447843
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.63948281
32SPI1_23127762_ChIP-Seq_K562_Human1.63381855
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.62155443
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61522263
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60633597
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60388883
37TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.58660951
38HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.57264077
39CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.55833437
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53144796
41TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51372131
42FOXA2_19822575_ChIP-Seq_HepG2_Human1.51197237
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50298680
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.49111780
45SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.48854349
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.48272661
47* RUNX1_22412390_ChIP-Seq_EML_Mouse1.47216029
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45585854
49MYC_22102868_ChIP-Seq_BL_Human1.45499241
50SOX2_27498859_Chip-Seq_STOMACH_Mouse1.45139321
51IRF8_27001747_Chip-Seq_BMDM_Mouse1.44711835
52PPAR_26484153_Chip-Seq_NCI-H1993_Human1.44152712
53FOXO3_23340844_ChIP-Seq_DLD1_Human1.43297493
54GATA1_19941826_ChIP-Seq_K562_Human1.41601019
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41536786
56STAT4_19710469_ChIP-ChIP_TH1__Mouse1.40103766
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39703719
58MAF_26560356_Chip-Seq_TH1_Human1.38684084
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38650107
60KDM2B_26808549_Chip-Seq_DND41_Human1.38233760
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.36646091
62BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32141461
63SALL4_18804426_ChIP-ChIP_XEN_Mouse1.30646883
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.29343085
65RUNX_20019798_ChIP-Seq_JUKART_Human1.29103275
66ESR1_21235772_ChIP-Seq_MCF-7_Human1.29010311
67TBX20_22080862_ChIP-Seq_HEART_Mouse1.25503241
68TBX20_22328084_ChIP-Seq_HEART_Mouse1.25503241
69GATA4_25053715_ChIP-Seq_YYC3_Human1.24895370
70PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.23632234
71GATA2_19941826_ChIP-Seq_K562_Human1.21064899
72IRF8_21731497_ChIP-ChIP_J774_Mouse1.18661224
73ZNF263_19887448_ChIP-Seq_K562_Human1.18380582
74UBF1/2_26484160_Chip-Seq_HMECs_Human1.17976588
75PU_27001747_Chip-Seq_BMDM_Mouse1.16936034
76KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16677879
77* SPI1_23547873_ChIP-Seq_NB4_Human1.15344800
78* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15256500
79KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15002415
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13742324
81* HNF4A_19822575_ChIP-Seq_HepG2_Human1.12685342
82RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12461357
83* ESR1_20079471_ChIP-ChIP_T-47D_Human1.12399656
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11453963
85E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09059424
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08809586
87CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07206409
88EP300_21415370_ChIP-Seq_HL-1_Mouse1.06357731
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04607045
90NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04607045
91* GATA1_19941827_ChIP-Seq_MEL_Mouse1.04521521
92CJUN_26792858_Chip-Seq_BT549_Human1.03091840
93FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02969876
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02145086
95NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.01566676
96SOX2_20726797_ChIP-Seq_SW620_Human1.01405098
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01193395
98KDM2B_26808549_Chip-Seq_JURKAT_Human1.01188241
99GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00813561
100PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.00679872
101KDM2B_26808549_Chip-Seq_K562_Human1.00275276
102UTX_26944678_Chip-Seq_JUKART_Human1.00217166
103* RUNX1_27514584_Chip-Seq_MCF-7_Human0.99551141
104NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98941337
105ELK3_25401928_ChIP-Seq_HUVEC_Human0.91959675
106RACK7_27058665_Chip-Seq_MCF-7_Human0.91867125
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91841492
108AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90336902
109GATA6_25053715_ChIP-Seq_YYC3_Human0.90170197
110VDR_24787735_ChIP-Seq_THP-1_Human0.89347438
111ATF3_27146783_Chip-Seq_COLON_Human0.89106715
112RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88246724
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88225518
114JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88028126
115ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87535651
116P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87247439
117ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87128743
118JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86686796
119PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86402163
120TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85012288
121SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.82078172
122MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.82059598
123LXR_22292898_ChIP-Seq_THP-1_Human0.79318510
124FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.79187318
125PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.78971349
126HIF1A_21447827_ChIP-Seq_MCF-7_Human0.78123115
127SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.76735872
128SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.76735872
129P63_26484246_Chip-Seq_KERATINOCYTES_Human0.75892714
130SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75780237
131CDX2_20551321_ChIP-Seq_CACO-2_Human0.74233789
132SCL_19346495_ChIP-Seq_HPC-7_Human0.73667226
133GATA3_24758297_ChIP-Seq_MCF-7_Human0.73624393
134FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.73461432
135CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.71948983
136FOXA1_25552417_ChIP-Seq_VCAP_Human0.71709171
137TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.69714250
138SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.68078711
139SOX9_24532713_ChIP-Seq_HFSC_Mouse0.67533501

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.66881864
2MP0002139_abnormal_hepatobiliary_system5.34434797
3MP0005085_abnormal_gallbladder_physiolo3.98276581
4MP0005365_abnormal_bile_salt3.90081478
5MP0009840_abnormal_foam_cell3.35068051
6MP0008875_abnormal_xenobiotic_pharmacok3.23576356
7MP0010329_abnormal_lipoprotein_level2.85009803
8MP0003252_abnormal_bile_duct2.83656433
9MP0004510_myositis2.73299455
10MP0003806_abnormal_nucleotide_metabolis2.63602163
11MP0003191_abnormal_cellular_cholesterol2.40773369
12MP0003705_abnormal_hypodermis_morpholog2.37825827
13MP0005083_abnormal_biliary_tract2.32668840
14MP0001666_abnormal_nutrient_absorption2.26849776
15MP0004130_abnormal_muscle_cell2.17451045
16MP0005332_abnormal_amino_acid1.95597359
17MP0003646_muscle_fatigue1.94212264
18MP0003656_abnormal_erythrocyte_physiolo1.92244364
19MP0003195_calcinosis1.91188065
20MP0002118_abnormal_lipid_homeostasis1.87811292
21MP0010234_abnormal_vibrissa_follicle1.87736882
22MP0000609_abnormal_liver_physiology1.85869302
23MP0003828_pulmonary_edema1.83270415
24MP0003091_abnormal_cell_migration1.77521203
25MP0003279_aneurysm1.73115068
26MP0002837_dystrophic_cardiac_calcinosis1.70228329
27MP0008438_abnormal_cutaneous_collagen1.65863520
28MP0008260_abnormal_autophagy1.65456250
29MP0002796_impaired_skin_barrier1.61619836
30MP0005058_abnormal_lysosome_morphology1.61172072
31MP0001835_abnormal_antigen_presentation1.60565859
32MP0004185_abnormal_adipocyte_glucose1.56130963
33MP0004233_abnormal_muscle_weight1.56076517
34MP0003172_abnormal_lysosome_physiology1.55673715
35MP0003453_abnormal_keratinocyte_physiol1.54063296
36MP0003950_abnormal_plasma_membrane1.53462238
37MP0010352_gastrointestinal_tract_polyps1.53307944
38MP0004019_abnormal_vitamin_homeostasis1.52008359
39MP0000858_altered_metastatic_potential1.49417438
40MP0005319_abnormal_enzyme/_coenzyme1.48696913
41MP0005451_abnormal_body_composition1.45031454
42MP0002138_abnormal_hepatobiliary_system1.44249157
43MP0002998_abnormal_bone_remodeling1.41415595
44MP0001851_eye_inflammation1.38973483
45MP0005666_abnormal_adipose_tissue1.38512854
46MP0005409_darkened_coat_color1.37670622
47MP0004084_abnormal_cardiac_muscle1.31732020
48MP0000685_abnormal_immune_system1.29747419
49MP0002971_abnormal_brown_adipose1.28889115
50MP0005025_abnormal_response_to1.27896663
51MP0005584_abnormal_enzyme/coenzyme_acti1.27890403
52MP0009785_altered_susceptibility_to1.27816848
53MP0003303_peritoneal_inflammation1.26280183
54MP0009643_abnormal_urine_homeostasis1.25446512
55MP0004272_abnormal_basement_membrane1.24957716
56MP0005000_abnormal_immune_tolerance1.24782817
57MP0005387_immune_system_phenotype1.22268087
58MP0001790_abnormal_immune_system1.22268087
59MP0004147_increased_porphyrin_level1.21627864
60MP0004036_abnormal_muscle_relaxation1.21160568
61MP0003436_decreased_susceptibility_to1.20615726
62MP0000343_altered_response_to1.20302657
63MP0002148_abnormal_hypersensitivity_rea1.18947758
64MP0010155_abnormal_intestine_physiology1.16371615
65MP0000751_myopathy1.15689154
66MP0010368_abnormal_lymphatic_system1.14025960
67MP0001873_stomach_inflammation1.13834024
68MP0000749_muscle_degeneration1.13176801
69MP0001849_ear_inflammation1.11005692
70MP0005330_cardiomyopathy1.10836907
71MP0005670_abnormal_white_adipose1.10089516
72MP0003448_altered_tumor_morphology1.09693418
73MP0002452_abnormal_antigen_presenting1.08800089
74MP0004087_abnormal_muscle_fiber1.07012305
75MP0005076_abnormal_cell_differentiation1.06858186
76MP0000604_amyloidosis1.05284493
77MP0002933_joint_inflammation1.04817198
78MP0003566_abnormal_cell_adhesion1.04126751
79MP0001800_abnormal_humoral_immune1.04031069
80MP0009764_decreased_sensitivity_to1.02229812
81MP0004883_abnormal_blood_vessel1.01334899
82MP0002332_abnormal_exercise_endurance1.01107552
83MP0005165_increased_susceptibility_to1.00970452
84MP0000598_abnormal_liver_morphology1.00945124
85MP0002896_abnormal_bone_mineralization1.00587260
86MP0002723_abnormal_immune_serum1.00442925
87MP0003763_abnormal_thymus_physiology0.99777781
88MP0003075_altered_response_to0.98691530
89MP0003690_abnormal_glial_cell0.98669776
90MP0009780_abnormal_chondrocyte_physiolo0.98624858
91MP0003221_abnormal_cardiomyocyte_apopto0.97238330
92MP0000759_abnormal_skeletal_muscle0.95790486
93MP0001216_abnormal_epidermal_layer0.95498418
94MP0003300_gastrointestinal_ulcer0.93862184
95MP0008469_abnormal_protein_level0.93529271
96MP0002420_abnormal_adaptive_immunity0.92862798
97MP0001819_abnormal_immune_cell0.92446545
98MP0000733_abnormal_muscle_development0.91518758
99MP0005275_abnormal_skin_tensile0.91228030
100MP0001853_heart_inflammation0.91063817
101MP0008775_abnormal_heart_ventricle0.90708836
102MP0002972_abnormal_cardiac_muscle0.90410673
103MP0003183_abnormal_peptide_metabolism0.90389844
104MP0003724_increased_susceptibility_to0.90368853
105MP0001845_abnormal_inflammatory_respons0.90173562
106MP0005501_abnormal_skin_physiology0.88318677
107MP0005464_abnormal_platelet_physiology0.87917996
108MP0001542_abnormal_bone_strength0.87223101
109MP0003045_fibrosis0.86881782
110MP0002405_respiratory_system_inflammati0.86854036
111MP0001915_intracranial_hemorrhage0.86822679
112MP0004858_abnormal_nervous_system0.86425197
113MP0001544_abnormal_cardiovascular_syste0.85886459
114MP0005385_cardiovascular_system_phenoty0.85886459
115MP0009763_increased_sensitivity_to0.85750408
116MP0003868_abnormal_feces_composition0.85529356
117MP0001533_abnormal_skeleton_physiology0.85273718
118MP0005167_abnormal_blood-brain_barrier0.84952593
119MP0006036_abnormal_mitochondrial_physio0.84823016
120MP0002254_reproductive_system_inflammat0.84776723
121MP0002269_muscular_atrophy0.83826239
122MP0005390_skeleton_phenotype0.83488395
123MP0005375_adipose_tissue_phenotype0.83479025
124MP0000747_muscle_weakness0.83345208
125MP0005334_abnormal_fat_pad0.82386843
126MP0003186_abnormal_redox_activity0.81641498
127MP0004264_abnormal_extraembryonic_tissu0.81507037
128MP0005620_abnormal_muscle_contractility0.81456720
129MP0003795_abnormal_bone_structure0.81424733
130MP0010630_abnormal_cardiac_muscle0.81309340
131MP0004381_abnormal_hair_follicle0.80947421
132MP0008004_abnormal_stomach_pH0.80887250
133MP0009384_cardiac_valve_regurgitation0.80307422
134MP0001958_emphysema0.78706829
135MP0002419_abnormal_innate_immunity0.77917986
136MP0002877_abnormal_melanocyte_morpholog0.77871951
137MP0000750_abnormal_muscle_regeneration0.75722035
138MP0004782_abnormal_surfactant_physiolog0.75194494
139MP0000249_abnormal_blood_vessel0.74922398
140MP0004947_skin_inflammation0.74706261
141MP0009642_abnormal_blood_homeostasis0.73907807
142MP0006138_congestive_heart_failure0.72573334
143MP0009115_abnormal_fat_cell0.71993159
144MP0005636_abnormal_mineral_homeostasis0.71673628
145MP0002078_abnormal_glucose_homeostasis0.71603692
146MP0005023_abnormal_wound_healing0.69631941
147MP0001756_abnormal_urination0.68773372
148MP0009697_abnormal_copulation0.68097495
149MP0006054_spinal_hemorrhage0.68044073
150MP0006082_CNS_inflammation0.67366481
151MP0005408_hypopigmentation0.66940602
152MP0005164_abnormal_response_to0.66154396
153MP0002136_abnormal_kidney_physiology0.64597036
154MP0005535_abnormal_body_temperature0.62494756
155MP0000767_abnormal_smooth_muscle0.62377556
156MP0002060_abnormal_skin_morphology0.62240829
157MP0005376_homeostasis/metabolism_phenot0.60321010
158MP0003011_delayed_dark_adaptation0.60039391
159MP0001764_abnormal_homeostasis0.59627400
160MP0005448_abnormal_energy_balance0.59193154
161MP0002106_abnormal_muscle_physiology0.58436497

Predicted human phenotypes

RankGene SetZ-score
1Xanthomatosis (HP:0000991)4.89082320
2Deep venous thrombosis (HP:0002625)4.82609170
3Intrahepatic cholestasis (HP:0001406)4.36613607
4Abnormality of monocarboxylic acid metabolism (HP:0010996)3.93506651
5Hyperlipoproteinemia (HP:0010980)3.80178233
6Abnormality of aromatic amino acid family metabolism (HP:0004338)3.77001039
7Hypobetalipoproteinemia (HP:0003563)3.75195308
8Complement deficiency (HP:0004431)3.68014702
9Abnormality of glutamine family amino acid metabolism (HP:0010902)3.63939420
10Hypoglycemic coma (HP:0001325)3.59187141
11Hypoalphalipoproteinemia (HP:0003233)3.44912404
12Hypolipoproteinemia (HP:0010981)3.42516848
13Hyperammonemia (HP:0001987)3.41778192
14Epidermoid cyst (HP:0200040)3.34795240
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.32818720
16Abnormality of fatty-acid metabolism (HP:0004359)3.21837290
17Premature rupture of membranes (HP:0001788)3.20819712
18Distal lower limb muscle weakness (HP:0009053)3.18597994
19Ketosis (HP:0001946)3.17256350
20Hyperglycinuria (HP:0003108)3.16787250
21Eczematoid dermatitis (HP:0000976)3.16426566
22Abnormality of the common coagulation pathway (HP:0010990)3.10709944
23Myocardial infarction (HP:0001658)3.10004743
24Protrusio acetabuli (HP:0003179)3.09872829
25Joint hemorrhage (HP:0005261)3.07910395
26Hypercholesterolemia (HP:0003124)3.04684587
27Round ear (HP:0100830)3.04049364
28Abnormality of serine family amino acid metabolism (HP:0010894)3.01255872
29Abnormality of glycine metabolism (HP:0010895)3.01255872
30Prolonged partial thromboplastin time (HP:0003645)3.00791942
31Polycythemia (HP:0001901)2.98875602
32Exercise-induced muscle cramps (HP:0003710)2.87898522
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.77869933
34Myoglobinuria (HP:0002913)2.77822910
35Abnormality of skeletal muscle fiber size (HP:0012084)2.77730656
36Abnormality of aspartate family amino acid metabolism (HP:0010899)2.77332832
37Abnormality of complement system (HP:0005339)2.76228821
38Hydroxyprolinuria (HP:0003080)2.73752085
39Abnormality of proline metabolism (HP:0010907)2.73752085
40Acanthocytosis (HP:0001927)2.71751116
41Increased variability in muscle fiber diameter (HP:0003557)2.71710029
42Abnormality of sulfur amino acid metabolism (HP:0004339)2.70788312
43Abnormality of glycolipid metabolism (HP:0010969)2.68850288
44Abnormality of liposaccharide metabolism (HP:0010968)2.68850288
45Abnormality of glycosphingolipid metabolism (HP:0004343)2.68850288
46Nemaline bodies (HP:0003798)2.68264808
47Systemic lupus erythematosus (HP:0002725)2.67251128
48Fat malabsorption (HP:0002630)2.67077748
49Centrally nucleated skeletal muscle fibers (HP:0003687)2.66105196
50Ketoacidosis (HP:0001993)2.65926792
51Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.65820114
52Nausea (HP:0002018)2.65632481
53Osteolytic defects of the phalanges of the hand (HP:0009771)2.65049100
54Osteolytic defects of the hand bones (HP:0009699)2.65049100
55Skin nodule (HP:0200036)2.63430959
56Recurrent gram-negative bacterial infections (HP:0005420)2.62829497
57Muscle fiber inclusion bodies (HP:0100299)2.62027230
58Right ventricular cardiomyopathy (HP:0011663)2.61627163
59Hyperglycinemia (HP:0002154)2.60548741
60Distal lower limb amyotrophy (HP:0008944)2.54412170
61Abnormality of macrophages (HP:0004311)2.53814586
62Asymmetric septal hypertrophy (HP:0001670)2.49252738
63Hyporeflexia of lower limbs (HP:0002600)2.49086877
64Vascular tortuosity (HP:0004948)2.48776151
65Exercise-induced myalgia (HP:0003738)2.48668382
66Arterial tortuosity (HP:0005116)2.46815101
67Abnormality of purine metabolism (HP:0004352)2.45541055
68Abnormality of dicarboxylic acid metabolism (HP:0010995)2.45358769
69Dicarboxylic aciduria (HP:0003215)2.45358769
70Recurrent abscess formation (HP:0002722)2.44310340
71Abnormality of the intrinsic pathway (HP:0010989)2.42513781
72Poikilocytosis (HP:0004447)2.42399090
73Muscle fiber splitting (HP:0003555)2.41883954
74Axonal loss (HP:0003447)2.40556143
75Hyperbilirubinemia (HP:0002904)2.40255522
76Hepatocellular carcinoma (HP:0001402)2.39920501
77Increased connective tissue (HP:0009025)2.38391864
78Rhabdomyolysis (HP:0003201)2.38073182
79Abnormal cartilage morphology (HP:0002763)2.36387986
80Cholelithiasis (HP:0001081)2.35627340
81Spinal rigidity (HP:0003306)2.30165106
82Vertebral compression fractures (HP:0002953)2.29769468
83Aortic aneurysm (HP:0004942)2.28651225
84Abnormal gallbladder morphology (HP:0012437)2.28010497
85Dysostosis multiplex (HP:0000943)2.26329196
86Gingivitis (HP:0000230)2.26315693
87Generalized aminoaciduria (HP:0002909)2.25242690
88Atrophic scars (HP:0001075)2.23736908
89Thin bony cortex (HP:0002753)2.23730982
90Spondylolisthesis (HP:0003302)2.23171959
91Abnormality of nucleobase metabolism (HP:0010932)2.22387794
92Striae distensae (HP:0001065)2.21100193
93Aortic dissection (HP:0002647)2.20096780
94Metabolic acidosis (HP:0001942)2.20093842
95Ventricular tachycardia (HP:0004756)2.17217878
96Spontaneous hematomas (HP:0007420)2.16557632
97Esophageal varix (HP:0002040)2.16174493
98Dilatation of the ascending aorta (HP:0005111)2.14418004
99Abnormality of methionine metabolism (HP:0010901)2.14077245
100Glomerulonephritis (HP:0000099)2.12818398
101Peritonitis (HP:0002586)2.12594302
102Reticulocytosis (HP:0001923)2.12005957
103Sensorimotor neuropathy (HP:0007141)2.11794115
104Cerebral aneurysm (HP:0004944)2.11553822
105Abnormality of iron homeostasis (HP:0011031)2.10768136
106Gout (HP:0001997)2.10501947
107Mildly elevated creatine phosphokinase (HP:0008180)2.06332698
108Recurrent bacterial skin infections (HP:0005406)2.06331326
109Slender build (HP:0001533)2.04455943
110Aneurysm (HP:0002617)2.02981147
111Abnormality of transition element cation homeostasis (HP:0011030)2.02702306
112Mucopolysacchariduria (HP:0008155)2.02410311
113Urinary glycosaminoglycan excretion (HP:0003541)2.02410311
114Vascular calcification (HP:0004934)2.02260493
115Cardiovascular calcification (HP:0011915)2.01454989
116Fragile skin (HP:0001030)2.00312159
117Hemorrhage of the eye (HP:0011885)1.96820459
118Increased IgE level (HP:0003212)1.95792840
119Cervical subluxation (HP:0003308)1.95410981
120Conjugated hyperbilirubinemia (HP:0002908)1.94918219
121Difficulty running (HP:0009046)1.94018047
122Mitral stenosis (HP:0001718)1.93005963
123Hyperglycemia (HP:0003074)1.92531546
124Abnormality of polysaccharide metabolism (HP:0011012)1.89994844
125Abnormality of glycosaminoglycan metabolism (HP:0004371)1.89994844
126Abnormality of mucopolysaccharide metabolism (HP:0011020)1.89994844
127Increased serum ferritin (HP:0003281)1.89571908
128Thick nail (HP:0001805)1.89456535
129Amyloidosis (HP:0011034)1.88905528
130Sudden death (HP:0001699)1.87972771
131EMG: myopathic abnormalities (HP:0003458)1.86456157
132Nephritis (HP:0000123)1.85838104
133Abnormality of serum amino acid levels (HP:0003112)1.85668007
134Protuberant abdomen (HP:0001538)1.85436381
135Abnormality of the gallbladder (HP:0005264)1.84693324
136Difficulty climbing stairs (HP:0003551)1.84592498
137* Cupped ribs (HP:0000887)1.81571193
138Flat acetabular roof (HP:0003180)1.80364383
139Steatorrhea (HP:0002570)1.79218428
140Achilles tendon contracture (HP:0001771)1.78636815
141Late onset (HP:0003584)1.78418796
142Autoimmune thrombocytopenia (HP:0001973)1.77906060
143Cellulitis (HP:0100658)1.77845284
144Type 1 muscle fiber predominance (HP:0003803)1.77246516
145Wormian bones (HP:0002645)1.77133568
146Ulnar deviation of the wrist (HP:0003049)1.76592556
147Pancreatitis (HP:0001733)1.76585123
148Abnormality of pyrimidine metabolism (HP:0004353)1.76081272
149Lipoatrophy (HP:0100578)1.75222690
150Malnutrition (HP:0004395)1.74172220
151Vacuolated lymphocytes (HP:0001922)1.74112846
152Increased cerebral lipofuscin (HP:0011813)1.72811691
153Thrombophlebitis (HP:0004418)1.72469647
154Neck muscle weakness (HP:0000467)1.72089244
155Abnormal tarsal ossification (HP:0008369)1.71532884
156Interstitial pulmonary disease (HP:0006530)1.71444026
157Increased mean platelet volume (HP:0011877)1.71064106
158Blue sclerae (HP:0000592)1.70676946
159Loss of speech (HP:0002371)1.67966948
160Abnormality of nail color (HP:0100643)1.66871663
161Hematochezia (HP:0002573)1.65075777
162Spinal cord lesions (HP:0100561)1.64546303
163Syringomyelia (HP:0003396)1.64546303
164Ankle contracture (HP:0006466)1.63974809
165Abnormality of the Achilles tendon (HP:0005109)1.63614832
166Orchitis (HP:0100796)1.63560536
167Bulbar palsy (HP:0001283)1.63333604
168Bladder diverticulum (HP:0000015)1.61650509
169Periodontitis (HP:0000704)1.61422023
170Bundle branch block (HP:0011710)1.58265675
171Bone pain (HP:0002653)1.57809124
172Myositis (HP:0100614)1.57356598
173Lower limb amyotrophy (HP:0007210)1.57148142
174Gingival bleeding (HP:0000225)1.56848333
175Broad face (HP:0000283)1.55942378
176Emphysema (HP:0002097)1.54464618
177Toxemia of pregnancy (HP:0100603)1.53565731
178Reduced subcutaneous adipose tissue (HP:0003758)1.53422501
179Scapular winging (HP:0003691)1.52943586
180Gastrointestinal infarctions (HP:0005244)1.52581347

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.04430475
2TRIB33.93642179
3TTN3.12172579
4ERN13.08387140
5PKN22.55254251
6BCKDK2.48930895
7PRPF4B2.48719155
8TBK12.25088129
9EPHB12.23503450
10SIK12.16333538
11LATS12.09815159
12RIPK11.94043626
13PDK31.87375916
14PDK41.87375916
15TYK21.80348365
16STK241.78131905
17MAP2K31.75795430
18PTK61.74305577
19FGFR41.66326135
20STK31.62638226
21OBSCN1.62186862
22NEK91.60214943
23MAP3K131.57928702
24ZAP701.57800926
25BLK1.57467263
26PDK21.54251132
27MST1R1.53599373
28KSR21.49944503
29RIPK41.43045344
30ERBB41.42523555
31MAP3K31.37244771
32FRK1.33207360
33JAK11.28439505
34PIK3CG1.28025061
35MAP4K11.25981811
36TESK11.25863120
37EPHA21.24534532
38CDC42BPA1.24312229
39TGFBR21.22334199
40SMG11.20451795
41CAMK1D1.17680109
42CDK121.17468008
43ABL21.16902026
44PIK3CA1.16000918
45FES1.15173668
46PDGFRA1.13387040
47DMPK1.11359444
48MAP3K11.09474526
49JAK31.09200656
50PRKAA21.08476644
51MAP3K21.07269802
52LMTK21.04708878
53PHKG21.00686259
54PHKG11.00686259
55TRPM71.00451264
56PDPK10.99379994
57IRAK40.97326196
58LRRK20.96587099
59TAOK20.96253477
60MOS0.94733842
61TAOK10.94086338
62MAPKAPK30.93084710
63JAK20.91848093
64KIT0.91146094
65PRKD20.88645155
66IKBKE0.88174863
67EPHB20.87249113
68TIE10.87019623
69STK380.86550472
70INSRR0.85366103
71BMX0.82433256
72STK100.82391788
73MAPK110.81831860
74MAP3K50.81661552
75CDK60.80434581
76PRKAA10.79992201
77PDGFRB0.77620801
78MET0.76576894
79MYLK0.76018454
80CSK0.75539620
81FLT30.75166471
82SCYL20.74875956
83IRAK30.74505630
84EPHA30.73489707
85FGR0.72910913
86RPS6KA20.70632478
87HCK0.70612430
88STK38L0.70381230
89SIK30.67321450
90MAP3K140.66459726
91GRK60.66305110
92STK40.62763198
93MAPK70.62119598
94CSF1R0.61524850
95PDK10.61073829
96ICK0.60913138
97PTK20.60792801
98GSK3A0.60538781
99PIM20.60494553
100CAMK1G0.60340431
101GRK70.58930057
102EEF2K0.58358338
103MAP3K80.57815090
104PRKD10.57692600
105NME20.57514934
106KSR10.56833955
107FER0.56544032
108MAP3K100.55842721
109TEC0.55409870
110BTK0.55107170
111MAP2K10.53823906
112KDR0.53370273
113LIMK10.53330313
114WNK40.52771248
115RET0.52418536
116MAPKAPK20.51746005
117RPS6KL10.51694838
118RPS6KC10.51694838
119ROCK20.51083198
120MAP3K70.51042307
121PKN10.49899293
122PRKG20.49896686
123NEK10.49729351
124DYRK1B0.49268419
125MTOR0.49139828
126ILK0.49109780
127IKBKB0.48316634
128ARAF0.48164513
129DDR20.47693467
130SYK0.47686535
131RAF10.47605164
132PIM10.47570122
133RPS6KB20.47415727
134SGK30.47150698
135MAPK120.46651110
136PINK10.45362086
137PRKACG0.45275994
138MAP3K60.42901563
139LATS20.41947326
140MAPK40.38914535
141ABL10.37202679
142PAK20.37186270
143MAP2K40.36024469
144IGF1R0.34518125
145FGFR30.34071564
146ERBB20.33937349
147PAK40.33672732

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.04472189
2Fatty acid degradation_Homo sapiens_hsa000712.95898731
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.79213393
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.75326724
5Nitrogen metabolism_Homo sapiens_hsa009102.69760235
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.47952933
7PPAR signaling pathway_Homo sapiens_hsa033202.39167937
8Arginine biosynthesis_Homo sapiens_hsa002202.36775262
9Tryptophan metabolism_Homo sapiens_hsa003802.34194306
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.33317134
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.31220736
12Propanoate metabolism_Homo sapiens_hsa006402.27305903
13Complement and coagulation cascades_Homo sapiens_hsa046102.21867061
14Fatty acid metabolism_Homo sapiens_hsa012122.18930652
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.06523883
16Caffeine metabolism_Homo sapiens_hsa002321.96409706
17Butanoate metabolism_Homo sapiens_hsa006501.87389214
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.84524647
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.78146481
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.76443746
21Fat digestion and absorption_Homo sapiens_hsa049751.76260437
22Starch and sucrose metabolism_Homo sapiens_hsa005001.76187698
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.74169137
24Staphylococcus aureus infection_Homo sapiens_hsa051501.73919432
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.73398663
26Peroxisome_Homo sapiens_hsa041461.72091750
27Acute myeloid leukemia_Homo sapiens_hsa052211.71733515
28Histidine metabolism_Homo sapiens_hsa003401.65092192
29beta-Alanine metabolism_Homo sapiens_hsa004101.59227728
30Chronic myeloid leukemia_Homo sapiens_hsa052201.55742925
31Sulfur metabolism_Homo sapiens_hsa009201.53886767
32B cell receptor signaling pathway_Homo sapiens_hsa046621.52723247
33Pancreatic cancer_Homo sapiens_hsa052121.51489418
34Pyruvate metabolism_Homo sapiens_hsa006201.51081963
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.50044351
36Carbon metabolism_Homo sapiens_hsa012001.49748691
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.46137411
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.45726208
39Bile secretion_Homo sapiens_hsa049761.44658733
40Non-small cell lung cancer_Homo sapiens_hsa052231.44358728
41Renal cell carcinoma_Homo sapiens_hsa052111.38361319
42Bladder cancer_Homo sapiens_hsa052191.37062257
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37024683
44Tuberculosis_Homo sapiens_hsa051521.34611541
45Fatty acid elongation_Homo sapiens_hsa000621.32276298
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30706344
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.29198332
48Steroid biosynthesis_Homo sapiens_hsa001001.28135260
49Chemical carcinogenesis_Homo sapiens_hsa052041.27173300
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.23460439
51Hepatitis C_Homo sapiens_hsa051601.23325002
52VEGF signaling pathway_Homo sapiens_hsa043701.21870320
53TNF signaling pathway_Homo sapiens_hsa046681.19453027
54Endometrial cancer_Homo sapiens_hsa052131.18666000
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18449952
56Proteoglycans in cancer_Homo sapiens_hsa052051.18389899
57Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.18281831
58ABC transporters_Homo sapiens_hsa020101.16442203
59Retinol metabolism_Homo sapiens_hsa008301.14271355
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.14177602
61Vitamin digestion and absorption_Homo sapiens_hsa049771.14019562
62Selenocompound metabolism_Homo sapiens_hsa004501.13050214
63Steroid hormone biosynthesis_Homo sapiens_hsa001401.12165878
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.11485164
65Phenylalanine metabolism_Homo sapiens_hsa003601.11441091
66Measles_Homo sapiens_hsa051621.07754253
67Shigellosis_Homo sapiens_hsa051311.05868095
68Influenza A_Homo sapiens_hsa051641.05662063
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04877727
70NF-kappa B signaling pathway_Homo sapiens_hsa040641.04792117
71Small cell lung cancer_Homo sapiens_hsa052221.02288953
72Regulation of actin cytoskeleton_Homo sapiens_hsa048101.02081603
73Neurotrophin signaling pathway_Homo sapiens_hsa047221.01835130
74Thyroid cancer_Homo sapiens_hsa052161.01768803
75Drug metabolism - other enzymes_Homo sapiens_hsa009831.00986232
76Biosynthesis of amino acids_Homo sapiens_hsa012301.00952218
77Platelet activation_Homo sapiens_hsa046111.00630611
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99551914
79Prolactin signaling pathway_Homo sapiens_hsa049170.98301433
80Hepatitis B_Homo sapiens_hsa051610.97622492
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97112928
82Lysine degradation_Homo sapiens_hsa003100.96959642
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.93644986
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92528395
85Arginine and proline metabolism_Homo sapiens_hsa003300.92187257
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.90095043
87Prion diseases_Homo sapiens_hsa050200.89859178
88Adherens junction_Homo sapiens_hsa045200.89733071
89Chemokine signaling pathway_Homo sapiens_hsa040620.89619272
90T cell receptor signaling pathway_Homo sapiens_hsa046600.89191172
91Glycerolipid metabolism_Homo sapiens_hsa005610.88987406
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88653644
93Glioma_Homo sapiens_hsa052140.88318870
94Apoptosis_Homo sapiens_hsa042100.87426317
95Insulin resistance_Homo sapiens_hsa049310.85498983
96Hematopoietic cell lineage_Homo sapiens_hsa046400.84968987
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.83256755
98Salmonella infection_Homo sapiens_hsa051320.82866919
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82026048
100Prostate cancer_Homo sapiens_hsa052150.81271304
101Tyrosine metabolism_Homo sapiens_hsa003500.80399252
102Endocytosis_Homo sapiens_hsa041440.79854119
103FoxO signaling pathway_Homo sapiens_hsa040680.79245694
104mTOR signaling pathway_Homo sapiens_hsa041500.79185545
105Pentose phosphate pathway_Homo sapiens_hsa000300.79051148
106Galactose metabolism_Homo sapiens_hsa000520.77878063
107Fatty acid biosynthesis_Homo sapiens_hsa000610.77579071
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76776911
109Graft-versus-host disease_Homo sapiens_hsa053320.76739602
110GnRH signaling pathway_Homo sapiens_hsa049120.76621964
111Vitamin B6 metabolism_Homo sapiens_hsa007500.76303288
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.76295233
113Allograft rejection_Homo sapiens_hsa053300.75520364
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75184284
115Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74086566
116Folate biosynthesis_Homo sapiens_hsa007900.74042466
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74007525
118Notch signaling pathway_Homo sapiens_hsa043300.73492628
119Glutathione metabolism_Homo sapiens_hsa004800.71450007
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71329385
121ErbB signaling pathway_Homo sapiens_hsa040120.69406691
122Autoimmune thyroid disease_Homo sapiens_hsa053200.63128221
123Lysosome_Homo sapiens_hsa041420.61405885
124Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61192946
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61028029
126Dorso-ventral axis formation_Homo sapiens_hsa043200.60906902
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59555741
128HIF-1 signaling pathway_Homo sapiens_hsa040660.59214786
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.58776866
130Estrogen signaling pathway_Homo sapiens_hsa049150.58147331
131Renin-angiotensin system_Homo sapiens_hsa046140.57831270
132Sphingolipid metabolism_Homo sapiens_hsa006000.57639512
133Inositol phosphate metabolism_Homo sapiens_hsa005620.57405515
134Antigen processing and presentation_Homo sapiens_hsa046120.57182521
135Colorectal cancer_Homo sapiens_hsa052100.54802556
136Mineral absorption_Homo sapiens_hsa049780.53209251
137AMPK signaling pathway_Homo sapiens_hsa041520.48095571
138Maturity onset diabetes of the young_Homo sapiens_hsa049500.46316400
139Glycosaminoglycan degradation_Homo sapiens_hsa005310.45183251
140Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40146609
141Amoebiasis_Homo sapiens_hsa051460.35699010
142Fructose and mannose metabolism_Homo sapiens_hsa000510.31858062
143Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31702743
144Insulin signaling pathway_Homo sapiens_hsa049100.31675232
145Cyanoamino acid metabolism_Homo sapiens_hsa004600.27224501
146* Metabolic pathways_Homo sapiens_hsa011000.27019318
147Sulfur relay system_Homo sapiens_hsa041220.26735900
148alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26035519
149Pertussis_Homo sapiens_hsa051330.25145054
150Protein digestion and absorption_Homo sapiens_hsa049740.25061939
151Other glycan degradation_Homo sapiens_hsa005110.24512725
152Glucagon signaling pathway_Homo sapiens_hsa049220.24184010
153ECM-receptor interaction_Homo sapiens_hsa045120.23889421
154Leishmaniasis_Homo sapiens_hsa051400.23683658
155Central carbon metabolism in cancer_Homo sapiens_hsa052300.22750992
156Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.21405658
157Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21358637
158Osteoclast differentiation_Homo sapiens_hsa043800.20522405
159Ovarian steroidogenesis_Homo sapiens_hsa049130.20290048
160Malaria_Homo sapiens_hsa051440.19389774
161Focal adhesion_Homo sapiens_hsa045100.19091550
162Toxoplasmosis_Homo sapiens_hsa051450.19024138
163Dilated cardiomyopathy_Homo sapiens_hsa054140.18794268
164Toll-like receptor signaling pathway_Homo sapiens_hsa046200.17311531
165Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17303559
166Viral myocarditis_Homo sapiens_hsa054160.16910850
167Phagosome_Homo sapiens_hsa041450.16780747
168Legionellosis_Homo sapiens_hsa051340.16520962

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