PCYT1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the cytidylyltransferase family. It is involved in the regulation of phosphatidylcholine biosynthesis. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)4.81084986
2central nervous system myelination (GO:0022010)4.81084986
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.74199458
4synaptic vesicle maturation (GO:0016188)4.73071458
5neuron cell-cell adhesion (GO:0007158)4.72530408
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.45957374
7cell migration in hindbrain (GO:0021535)4.38427274
8synaptic vesicle exocytosis (GO:0016079)4.33148600
9glutamate secretion (GO:0014047)4.24343818
10layer formation in cerebral cortex (GO:0021819)4.13273267
11regulation of synaptic vesicle exocytosis (GO:2000300)4.12575860
12locomotory exploration behavior (GO:0035641)4.11283908
13establishment of mitochondrion localization (GO:0051654)4.10218614
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.09778665
15protein neddylation (GO:0045116)4.07649274
16vocalization behavior (GO:0071625)4.06107482
17protein localization to synapse (GO:0035418)3.97182309
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.96305133
19neuron recognition (GO:0008038)3.92242261
20pyrimidine nucleobase catabolic process (GO:0006208)3.84084768
21axonal fasciculation (GO:0007413)3.80618663
22dendritic spine morphogenesis (GO:0060997)3.76789134
23negative regulation of microtubule polymerization (GO:0031115)3.71387615
24central nervous system projection neuron axonogenesis (GO:0021952)3.69620178
25positive regulation of synapse maturation (GO:0090129)3.69518285
26mitochondrion transport along microtubule (GO:0047497)3.66164070
27establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.66164070
28regulation of synaptic vesicle transport (GO:1902803)3.61015695
29regulation of neuronal synaptic plasticity (GO:0048168)3.58127538
30neuronal action potential propagation (GO:0019227)3.55042512
31regulation of glutamate receptor signaling pathway (GO:1900449)3.52520114
32dendrite morphogenesis (GO:0048813)3.47681199
33regulation of gene silencing by RNA (GO:0060966)3.46916066
34regulation of posttranscriptional gene silencing (GO:0060147)3.46916066
35regulation of gene silencing by miRNA (GO:0060964)3.46916066
36ionotropic glutamate receptor signaling pathway (GO:0035235)3.44666762
37exploration behavior (GO:0035640)3.42376966
38regulation of long-term neuronal synaptic plasticity (GO:0048169)3.42298137
39negative regulation of translation, ncRNA-mediated (GO:0040033)3.36310938
40regulation of translation, ncRNA-mediated (GO:0045974)3.36310938
41negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.36310938
42proline transport (GO:0015824)3.33759347
43postsynaptic membrane organization (GO:0001941)3.32988115
44gamma-aminobutyric acid transport (GO:0015812)3.28134382
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.27163390
46neurotransmitter secretion (GO:0007269)3.27159251
47synaptic vesicle docking involved in exocytosis (GO:0016081)3.26812775
48presynaptic membrane organization (GO:0097090)3.20436232
49DNA double-strand break processing (GO:0000729)3.18281560
50synaptic transmission, glutamatergic (GO:0035249)3.18106753
51presynaptic membrane assembly (GO:0097105)3.16801879
52cerebral cortex radially oriented cell migration (GO:0021799)3.15787721
53glutamate receptor signaling pathway (GO:0007215)3.10511996
54auditory behavior (GO:0031223)3.07526717
55regulation of synapse maturation (GO:0090128)3.06680869
56regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.05431397
57negative regulation of heart rate (GO:0010459)3.03890912
58cerebellar granule cell differentiation (GO:0021707)3.02598492
59neuron-neuron synaptic transmission (GO:0007270)3.01991573
60limb bud formation (GO:0060174)3.01853053
61negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.99902930
62regulation of synapse structural plasticity (GO:0051823)2.99180892
63cerebellum development (GO:0021549)2.98816923
64cerebellar Purkinje cell differentiation (GO:0021702)2.96208686
65transmission of nerve impulse (GO:0019226)2.95824958
66microtubule depolymerization (GO:0007019)2.95773243
67chromatin remodeling at centromere (GO:0031055)2.93815733
68central nervous system neuron axonogenesis (GO:0021955)2.93436307
69synapse assembly (GO:0007416)2.92175872
70regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.92024439
71epithelial cilium movement (GO:0003351)2.91779681
72axon extension (GO:0048675)2.90913575
73regulation of respiratory system process (GO:0044065)2.90466843
74innervation (GO:0060384)2.87772200
75behavioral response to nicotine (GO:0035095)2.87588256
76negative regulation of dendrite development (GO:2000171)2.87558121
77positive regulation of dendritic spine morphogenesis (GO:0061003)2.84956691
78neurotransmitter uptake (GO:0001504)2.84213010
79organelle transport along microtubule (GO:0072384)2.84054601
80nucleobase catabolic process (GO:0046113)2.83434615
81neuromuscular process controlling balance (GO:0050885)2.82074507
82hippocampus development (GO:0021766)2.81692094
83neurotransmitter transport (GO:0006836)2.80859544
84long-chain fatty acid biosynthetic process (GO:0042759)2.80595140
85response to auditory stimulus (GO:0010996)2.80438607
86regulation of synaptic plasticity (GO:0048167)2.80218467
87G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.80204581
88neurotransmitter-gated ion channel clustering (GO:0072578)2.79486090
89mechanosensory behavior (GO:0007638)2.78960299
90adult walking behavior (GO:0007628)2.78672210
91cilium movement (GO:0003341)2.78196308
92positive regulation of dendritic spine development (GO:0060999)2.75976056
93regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.75935711
94regulation of dendritic spine morphogenesis (GO:0061001)2.74620419
95glycine transport (GO:0015816)2.74562065
96neuronal ion channel clustering (GO:0045161)2.73387420
97negative regulation of DNA-dependent DNA replication (GO:2000104)2.73127744
98positive regulation of synapse assembly (GO:0051965)2.72534429
99lung epithelium development (GO:0060428)2.72038475
100regulation of excitatory postsynaptic membrane potential (GO:0060079)2.71481276
101CENP-A containing nucleosome assembly (GO:0034080)2.70318282
102dendrite development (GO:0016358)2.70032606
103detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.69283995
104positive regulation of membrane potential (GO:0045838)2.69210780
105long-term memory (GO:0007616)2.68628167
106histone exchange (GO:0043486)2.68221954
107positive regulation of synaptic transmission, GABAergic (GO:0032230)2.68178447
108axonemal dynein complex assembly (GO:0070286)2.68157237
109microtubule polymerization or depolymerization (GO:0031109)2.67914362
110regulation of neurotransmitter secretion (GO:0046928)2.67353813
111negative regulation of axonogenesis (GO:0050771)2.67174786
112membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.65149329
113regulation of cilium movement (GO:0003352)2.64813011
114dendritic spine organization (GO:0097061)2.64083200
115regulation of respiratory gaseous exchange (GO:0043576)2.63759761
116establishment of nucleus localization (GO:0040023)2.61962952
117neurofilament cytoskeleton organization (GO:0060052)2.61948957
118synapse organization (GO:0050808)2.61733475
119synaptic vesicle endocytosis (GO:0048488)2.61060061
120cochlea development (GO:0090102)2.61032342
121positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.60952641
122kidney morphogenesis (GO:0060993)2.60635738
123negative regulation of synaptic transmission, GABAergic (GO:0032229)2.60494967
124nonmotile primary cilium assembly (GO:0035058)2.60121651
125regulation of postsynaptic membrane potential (GO:0060078)2.58831448
126neuron projection extension (GO:1990138)2.58110259
127regulation of synapse assembly (GO:0051963)2.57520161
128axonogenesis (GO:0007409)2.57297932
129regulation of collateral sprouting (GO:0048670)2.51325701
130behavioral response to cocaine (GO:0048148)2.44333224
131regulation of development, heterochronic (GO:0040034)2.43445439
132L-serine metabolic process (GO:0006563)2.43171549
133protein localization to cilium (GO:0061512)2.43016484
134regulation of neurotransmitter uptake (GO:0051580)2.42978028
135cilium or flagellum-dependent cell motility (GO:0001539)2.42597995
136lung-associated mesenchyme development (GO:0060484)2.41797815
137regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.40588279
138negative regulation of response to food (GO:0032096)2.36611747
139negative regulation of appetite (GO:0032099)2.36611747
140intraciliary transport (GO:0042073)2.36529122
141single strand break repair (GO:0000012)2.34092023
142startle response (GO:0001964)2.32661634
143atrial cardiac muscle cell action potential (GO:0086014)2.32250566
144C4-dicarboxylate transport (GO:0015740)2.31014786
145response to pheromone (GO:0019236)2.30724548
146negative regulation of neurotransmitter transport (GO:0051589)2.30421271
147regulation of histone H3-K9 methylation (GO:0051570)2.30338165
148protein polyglutamylation (GO:0018095)2.30199380
149regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.30104385
150axoneme assembly (GO:0035082)2.29712541
151cilium organization (GO:0044782)2.29387087
152cilium assembly (GO:0042384)2.28404053
153regulation of non-canonical Wnt signaling pathway (GO:2000050)2.25632455
154membrane depolarization during action potential (GO:0086010)2.25322825
155somatic diversification of immune receptors via somatic mutation (GO:0002566)2.24972427
156somatic hypermutation of immunoglobulin genes (GO:0016446)2.24972427
157regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.24907460
158regulation of mitotic spindle checkpoint (GO:1903504)2.24907460
159regulation of timing of cell differentiation (GO:0048505)2.24804983
160centriole replication (GO:0007099)2.24205822
161negative regulation of transcription regulatory region DNA binding (GO:2000678)2.23814924
162generation of neurons (GO:0048699)2.23441556
163negative regulation of cytosolic calcium ion concentration (GO:0051481)2.22646798
164negative regulation of DNA recombination (GO:0045910)2.21314332
165lateral sprouting from an epithelium (GO:0060601)2.20346101
166regulation of nuclear cell cycle DNA replication (GO:0033262)2.19236116

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.31987508
2GBX2_23144817_ChIP-Seq_PC3_Human3.39178319
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.05073119
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.03555069
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.00282008
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.76919156
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.73569848
8REST_21632747_ChIP-Seq_MESCs_Mouse2.71154940
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.55413988
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.48535887
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.48535887
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.37684462
13VDR_22108803_ChIP-Seq_LS180_Human2.33138262
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.26760125
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.26431885
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.24667082
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15785554
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.13511420
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12945252
20POU5F1_16153702_ChIP-ChIP_HESCs_Human2.11622004
21DROSHA_22980978_ChIP-Seq_HELA_Human2.10538873
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.10328978
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.08305879
24EWS_26573619_Chip-Seq_HEK293_Human2.07705049
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.07260359
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.05212574
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.04660171
28FUS_26573619_Chip-Seq_HEK293_Human2.04178255
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02706245
30EED_16625203_ChIP-ChIP_MESCs_Mouse2.02549576
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.99728327
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99629660
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.97529815
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93148356
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90790546
36IGF1R_20145208_ChIP-Seq_DFB_Human1.78865522
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69979303
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68150957
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67456200
40AR_21572438_ChIP-Seq_LNCaP_Human1.67361734
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.64611030
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58126367
43TAF15_26573619_Chip-Seq_HEK293_Human1.57401556
44RNF2_27304074_Chip-Seq_NSC_Mouse1.55964858
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.53341283
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52886550
47* SOX2_16153702_ChIP-ChIP_HESCs_Human1.52040446
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50865440
49SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.49793146
50RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.48765344
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48581086
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46072430
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.45644639
54* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.45526707
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44792054
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44043376
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40981372
58RING1B_27294783_Chip-Seq_NPCs_Mouse1.39784021
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38903798
60* SMAD4_21799915_ChIP-Seq_A2780_Human1.38065078
61* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33004753
62GATA1_26923725_Chip-Seq_HPCs_Mouse1.32610767
63RING1B_27294783_Chip-Seq_ESCs_Mouse1.32344585
64KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.29535760
65* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29343014
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.28412503
67IRF1_19129219_ChIP-ChIP_H3396_Human1.28125809
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27607543
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.26968144
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25780951
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.25318008
72STAT3_23295773_ChIP-Seq_U87_Human1.24987733
73OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.22475906
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22375173
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20565512
76YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20472252
77* P300_19829295_ChIP-Seq_ESCs_Human1.19675024
78TBX3_20139965_ChIP-Seq_ESCs_Mouse1.18981783
79ZNF274_21170338_ChIP-Seq_K562_Hela1.18962382
80TBX3_20139965_ChIP-Seq_MESCs_Mouse1.18803027
81BCAT_22108803_ChIP-Seq_LS180_Human1.18114574
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17662767
83RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16642358
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15983907
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14282285
86KDM2B_26808549_Chip-Seq_K562_Human1.14170327
87SALL1_21062744_ChIP-ChIP_HESCs_Human1.13713662
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.13621402
89RUNX2_22187159_ChIP-Seq_PCA_Human1.12625032
90WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12254031
91* NANOG_16153702_ChIP-ChIP_HESCs_Human1.11822004
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10956478
93HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10391111
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09563974
95SOX2_19829295_ChIP-Seq_ESCs_Human1.09374022
96NANOG_19829295_ChIP-Seq_ESCs_Human1.09374022
97MYC_18940864_ChIP-ChIP_HL60_Human1.08700584
98CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.07995707
99CBP_20019798_ChIP-Seq_JUKART_Human1.07446692
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07446692
101AR_19668381_ChIP-Seq_PC3_Human1.07334493
102NANOG_18555785_Chip-Seq_ESCs_Mouse1.07312691
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07091167
104STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06917660
105TCF4_23295773_ChIP-Seq_U87_Human1.06217109
106NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05934774
107TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05493062
108TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05231025
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04876808
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04876808
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04682282
112ER_23166858_ChIP-Seq_MCF-7_Human1.03207652
113TCF4_22108803_ChIP-Seq_LS180_Human1.03015409
114ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02701904
115SMAD4_21741376_ChIP-Seq_EPCs_Human1.02169445
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01234987
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01116416
118NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00907537
119KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00627062
120P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99099319
121SOX9_26525672_Chip-Seq_HEART_Mouse0.98535682
122PIAS1_25552417_ChIP-Seq_VCAP_Human0.98004559
123JUN_21703547_ChIP-Seq_K562_Human0.97718847
124GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97170380
125EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96761703
126TAL1_26923725_Chip-Seq_HPCs_Mouse0.96552789
127DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96186013
128VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95624158
129CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95220344
130* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.94812231
131EZH2_27294783_Chip-Seq_NPCs_Mouse0.94246399
132EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93842898
133NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.93632589
134EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92983376
135SMAD3_21741376_ChIP-Seq_ESCs_Human0.92744985
136AR_25329375_ChIP-Seq_VCAP_Human0.92428893
137AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91819660
138ARNT_22903824_ChIP-Seq_MCF-7_Human0.91739186
139TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91388652
140TET1_21490601_ChIP-Seq_MESCs_Mouse0.91288802
141LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89788994
142CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89427757
143TP53_20018659_ChIP-ChIP_R1E_Mouse0.88500856
144STAT6_21828071_ChIP-Seq_BEAS2B_Human0.87687647
145NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.87449512
146SMAD4_21741376_ChIP-Seq_HESCs_Human0.86922663

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.19684675
2MP0004859_abnormal_synaptic_plasticity4.54994431
3MP0005423_abnormal_somatic_nervous3.95763958
4MP0004270_analgesia3.52210689
5MP0003635_abnormal_synaptic_transmissio3.00425103
6MP0008877_abnormal_DNA_methylation2.73429285
7MP0009780_abnormal_chondrocyte_physiolo2.68897897
8MP0000778_abnormal_nervous_system2.68785200
9MP0002063_abnormal_learning/memory/cond2.57522879
10MP0002734_abnormal_mechanical_nocicepti2.39303191
11MP0001486_abnormal_startle_reflex2.28475792
12MP0009745_abnormal_behavioral_response2.25998648
13MP0001968_abnormal_touch/_nociception2.21809423
14MP0000566_synostosis2.21658967
15MP0002064_seizures2.20563699
16MP0002102_abnormal_ear_morphology2.16054157
17MP0006276_abnormal_autonomic_nervous2.10275340
18MP0002735_abnormal_chemical_nociception2.04699254
19MP0002272_abnormal_nervous_system2.00853099
20MP0002572_abnormal_emotion/affect_behav2.00712499
21MP0002184_abnormal_innervation1.98114080
22MP0002733_abnormal_thermal_nociception1.94776744
23MP0009046_muscle_twitch1.88076016
24MP0000955_abnormal_spinal_cord1.86072592
25MP0004885_abnormal_endolymph1.80777243
26MP0001188_hyperpigmentation1.75512262
27MP0004811_abnormal_neuron_physiology1.72133542
28MP0001970_abnormal_pain_threshold1.71708029
29MP0001529_abnormal_vocalization1.71310500
30MP0001984_abnormal_olfaction1.64272388
31MP0004858_abnormal_nervous_system1.63032727
32MP0003283_abnormal_digestive_organ1.61936718
33MP0002557_abnormal_social/conspecific_i1.61856169
34MP0001440_abnormal_grooming_behavior1.60025847
35MP0002822_catalepsy1.57520517
36MP0003718_maternal_effect1.56941825
37MP0002736_abnormal_nociception_after1.56763898
38MP0002067_abnormal_sensory_capabilities1.56030635
39MP0003329_amyloid_beta_deposits1.55283948
40MP0005499_abnormal_olfactory_system1.54755938
41MP0005394_taste/olfaction_phenotype1.54755938
42MP0002882_abnormal_neuron_morphology1.54457623
43MP0004924_abnormal_behavior1.53097738
44MP0005386_behavior/neurological_phenoty1.53097738
45MP0003122_maternal_imprinting1.50388035
46MP0001293_anophthalmia1.50363868
47MP0005646_abnormal_pituitary_gland1.50174898
48MP0005551_abnormal_eye_electrophysiolog1.47352589
49MP0002638_abnormal_pupillary_reflex1.43154872
50MP0005645_abnormal_hypothalamus_physiol1.43125232
51MP0008569_lethality_at_weaning1.42611988
52MP0010030_abnormal_orbit_morphology1.39438931
53MP0008789_abnormal_olfactory_epithelium1.35534881
54MP0003787_abnormal_imprinting1.35266194
55MP0008058_abnormal_DNA_repair1.35247332
56MP0002152_abnormal_brain_morphology1.33821258
57MP0005248_abnormal_Harderian_gland1.29867872
58MP0003011_delayed_dark_adaptation1.29234268
59MP0008872_abnormal_physiological_respon1.28291854
60MP0002751_abnormal_autonomic_nervous1.26214568
61MP0003861_abnormal_nervous_system1.22709007
62MP0005253_abnormal_eye_physiology1.22582898
63MP0002066_abnormal_motor_capabilities/c1.22440768
64MP0004742_abnormal_vestibular_system1.21947439
65MP0006292_abnormal_olfactory_placode1.19270751
66MP0003938_abnormal_ear_development1.19171056
67MP0000631_abnormal_neuroendocrine_gland1.17645228
68MP0004133_heterotaxia1.13382650
69MP0002653_abnormal_ependyma_morphology1.08498071
70MP0002752_abnormal_somatic_nervous1.08163450
71MP0001177_atelectasis1.08109475
72MP0003121_genomic_imprinting1.04277346
73MP0001963_abnormal_hearing_physiology1.03981053
74MP0001485_abnormal_pinna_reflex1.03861983
75MP0000579_abnormal_nail_morphology1.03202032
76MP0004142_abnormal_muscle_tone1.01847370
77MP0003634_abnormal_glial_cell1.00095216
78MP0000026_abnormal_inner_ear0.99914269
79MP0005084_abnormal_gallbladder_morpholo0.99889766
80MP0001905_abnormal_dopamine_level0.99693658
81MP0001299_abnormal_eye_distance/0.99040907
82MP0005187_abnormal_penis_morphology0.98679542
83MP0002938_white_spotting0.98163102
84MP0002229_neurodegeneration0.96297703
85MP0003567_abnormal_fetal_cardiomyocyte0.95253312
86MP0001501_abnormal_sleep_pattern0.92615831
87MP0002090_abnormal_vision0.92236069
88MP0002249_abnormal_larynx_morphology0.91539485
89MP0001348_abnormal_lacrimal_gland0.91035643
90MP0003879_abnormal_hair_cell0.91031855
91MP0001286_abnormal_eye_development0.90918929
92* MP0003698_abnormal_male_reproductive0.90624733
93MP0003119_abnormal_digestive_system0.89950327
94MP0010094_abnormal_chromosome_stability0.89813338
95MP0003878_abnormal_ear_physiology0.89284658
96MP0005377_hearing/vestibular/ear_phenot0.89284658
97MP0005464_abnormal_platelet_physiology0.87261742
98MP0003632_abnormal_nervous_system0.86356997
99MP0009672_abnormal_birth_weight0.86091662
100MP0000537_abnormal_urethra_morphology0.85801035
101MP0004215_abnormal_myocardial_fiber0.82375208
102MP0008932_abnormal_embryonic_tissue0.82313660
103MP0003631_nervous_system_phenotype0.80893218
104MP0000569_abnormal_digit_pigmentation0.80481052
105MP0006072_abnormal_retinal_apoptosis0.79985148
106MP0003755_abnormal_palate_morphology0.79892228
107MP0001502_abnormal_circadian_rhythm0.78357196
108MP0004147_increased_porphyrin_level0.78249688
109MP0004134_abnormal_chest_morphology0.77914790
110MP0003111_abnormal_nucleus_morphology0.77875273
111MP0002909_abnormal_adrenal_gland0.77682019
112MP0002089_abnormal_postnatal_growth/wei0.77418857
113MP0002233_abnormal_nose_morphology0.77149361
114MP0000049_abnormal_middle_ear0.77069015
115MP0009703_decreased_birth_body0.76980765
116MP0003315_abnormal_perineum_morphology0.76660856
117MP0005195_abnormal_posterior_eye0.76076392
118MP0000920_abnormal_myelination0.74798793
119MP0003633_abnormal_nervous_system0.74251230
120MP0003937_abnormal_limbs/digits/tail_de0.73861061
121MP0004085_abnormal_heartbeat0.73834920
122MP0000462_abnormal_digestive_system0.73080724
123MP0002069_abnormal_eating/drinking_beha0.71079678
124MP0004145_abnormal_muscle_electrophysio0.70037056
125MP0003136_yellow_coat_color0.69302775
126MP0003890_abnormal_embryonic-extraembry0.66947152
127MP0001986_abnormal_taste_sensitivity0.66892685
128MP0002081_perinatal_lethality0.66563346
129MP0000428_abnormal_craniofacial_morphol0.66548500

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.66589177
2Focal motor seizures (HP:0011153)3.96268841
3Focal seizures (HP:0007359)3.61420258
4Supranuclear gaze palsy (HP:0000605)3.48434972
5Alacrima (HP:0000522)3.38166767
6Abnormality of the corticospinal tract (HP:0002492)3.30497986
7Epileptic encephalopathy (HP:0200134)3.10672496
8Abnormality of the labia minora (HP:0012880)3.10438501
9Colon cancer (HP:0003003)2.98522015
10Progressive cerebellar ataxia (HP:0002073)2.98443883
11Insidious onset (HP:0003587)2.97238337
12Termporal pattern (HP:0011008)2.97238337
13Ankle clonus (HP:0011448)2.96099868
14Septo-optic dysplasia (HP:0100842)2.95988121
15Megalencephaly (HP:0001355)2.94503070
16Aplasia involving bones of the upper limbs (HP:0009823)2.88905593
17Aplasia of the phalanges of the hand (HP:0009802)2.88905593
18Aplasia involving bones of the extremities (HP:0009825)2.88905593
19Abnormal respiratory epithelium morphology (HP:0012253)2.88190620
20Abnormal respiratory motile cilium morphology (HP:0005938)2.88190620
21Neurofibrillary tangles (HP:0002185)2.84139393
22Abnormal ciliary motility (HP:0012262)2.82806600
23Optic nerve hypoplasia (HP:0000609)2.81150507
24Decreased lacrimation (HP:0000633)2.79650408
25Pancreatic fibrosis (HP:0100732)2.79323467
26Visual hallucinations (HP:0002367)2.78480289
27Atonic seizures (HP:0010819)2.77511649
28Febrile seizures (HP:0002373)2.75254259
29Degeneration of the lateral corticospinal tracts (HP:0002314)2.73423981
30Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.73423981
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.71872973
32Absent/shortened dynein arms (HP:0200106)2.71872973
33True hermaphroditism (HP:0010459)2.70646228
34Pancreatic cysts (HP:0001737)2.66761644
35Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.65697404
36Spastic gait (HP:0002064)2.64303884
37Urinary bladder sphincter dysfunction (HP:0002839)2.64095151
38Decreased central vision (HP:0007663)2.62144791
39Urinary urgency (HP:0000012)2.55429537
40Abnormal respiratory motile cilium physiology (HP:0012261)2.53492185
41Cerebral inclusion bodies (HP:0100314)2.52267819
42Amyotrophic lateral sclerosis (HP:0007354)2.50474501
43Action tremor (HP:0002345)2.48989076
44Broad-based gait (HP:0002136)2.45849597
45Limb dystonia (HP:0002451)2.43957020
46Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.40265800
47Heterotopia (HP:0002282)2.37007030
48Drooling (HP:0002307)2.36220815
49Excessive salivation (HP:0003781)2.36220815
50Rhinitis (HP:0012384)2.33760227
51Mutism (HP:0002300)2.32431332
52Impaired vibration sensation in the lower limbs (HP:0002166)2.29734633
53Specific learning disability (HP:0001328)2.29225034
54Abolished electroretinogram (ERG) (HP:0000550)2.27596277
55Abnormality of midbrain morphology (HP:0002418)2.25331776
56Molar tooth sign on MRI (HP:0002419)2.25331776
57Nephronophthisis (HP:0000090)2.24495554
58Polyphagia (HP:0002591)2.20452384
59Insomnia (HP:0100785)2.20400712
60Diplopia (HP:0000651)2.20273561
61Abnormality of binocular vision (HP:0011514)2.20273561
62Facial hemangioma (HP:0000329)2.19776053
63Dysdiadochokinesis (HP:0002075)2.18778158
64Increased mean platelet volume (HP:0011877)2.18279166
65Hyperventilation (HP:0002883)2.17334035
66Dialeptic seizures (HP:0011146)2.17125419
67Split foot (HP:0001839)2.16788708
68Intestinal atresia (HP:0011100)2.14339514
69Absence seizures (HP:0002121)2.13274710
70Gait imbalance (HP:0002141)2.10728485
71Amblyopia (HP:0000646)2.10598749
72Morphological abnormality of the pyramidal tract (HP:0002062)2.09865557
73Abnormal eating behavior (HP:0100738)2.09421102
74Partial duplication of thumb phalanx (HP:0009944)2.06546672
75Genetic anticipation (HP:0003743)2.05800682
76Truncal ataxia (HP:0002078)2.05638246
77Generalized tonic-clonic seizures (HP:0002069)2.04991081
78Dyschromatopsia (HP:0007641)2.03392101
79EEG with generalized epileptiform discharges (HP:0011198)2.02481752
80Thickened helices (HP:0000391)2.01658018
81Dysmetria (HP:0001310)2.01061991
82Epileptiform EEG discharges (HP:0011182)2.00602477
83Hypsarrhythmia (HP:0002521)2.00542712
84Genital tract atresia (HP:0001827)2.00531649
85Absent speech (HP:0001344)2.00135118
86Papilledema (HP:0001085)1.99950474
87Hypoplasia of the brainstem (HP:0002365)1.99173660
88Aplasia/Hypoplasia of the brainstem (HP:0007362)1.99173660
89Hyperglycinemia (HP:0002154)1.99084062
90Abnormality of salivation (HP:0100755)1.98778477
91Depression (HP:0000716)1.98320541
92Cortical dysplasia (HP:0002539)1.97940629
93Cerebral hypomyelination (HP:0006808)1.97912244
94Chronic bronchitis (HP:0004469)1.97103991
95Poikilocytosis (HP:0004447)1.96499958
96Anencephaly (HP:0002323)1.96431995
97Supernumerary spleens (HP:0009799)1.96417339
98Lower limb muscle weakness (HP:0007340)1.95180250
99Vaginal atresia (HP:0000148)1.94881268
100Poor eye contact (HP:0000817)1.94862843
101Chronic hepatic failure (HP:0100626)1.94620888
102Pheochromocytoma (HP:0002666)1.93015671
103Cupped ear (HP:0000378)1.92940958
104Hemiparesis (HP:0001269)1.92154255
105Abnormal lung lobation (HP:0002101)1.90134057
106Protruding tongue (HP:0010808)1.89865128
107Ulnar claw (HP:0001178)1.89431991
108Anophthalmia (HP:0000528)1.89199230
109Abnormality of the astrocytes (HP:0100707)1.89067568
110Astrocytoma (HP:0009592)1.89067568
111Gastrointestinal atresia (HP:0002589)1.88359323
112Pendular nystagmus (HP:0012043)1.88281520
113Macroorchidism (HP:0000053)1.87261478
114Prolonged bleeding time (HP:0003010)1.86772268
115Sleep apnea (HP:0010535)1.86551511
116Bilateral microphthalmos (HP:0007633)1.86538054
117Scanning speech (HP:0002168)1.86249059
118Absent septum pellucidum (HP:0001331)1.86155806
119Medial flaring of the eyebrow (HP:0010747)1.85246331
120Abnormality of the salivary glands (HP:0010286)1.84977931
121Peripheral hypomyelination (HP:0007182)1.84832932
122Postural instability (HP:0002172)1.84169552
123Gaze-evoked nystagmus (HP:0000640)1.83740864
124Abnormality of the lower motor neuron (HP:0002366)1.83724795
125Akinesia (HP:0002304)1.83647772
126Aplasia/Hypoplasia of the sternum (HP:0006714)1.83299496
127Retinal dysplasia (HP:0007973)1.83245780
128Acanthocytosis (HP:0001927)1.81915799
129Failure to thrive in infancy (HP:0001531)1.80256347
130Abnormality of the septum pellucidum (HP:0007375)1.80228710
131Impaired smooth pursuit (HP:0007772)1.79556895
132Abnormality of the renal medulla (HP:0100957)1.77792942
133Sclerocornea (HP:0000647)1.77446886
134Inability to walk (HP:0002540)1.77123321
135Spastic paraplegia (HP:0001258)1.76992055
136Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.76158898
137Paraplegia (HP:0010550)1.76028102
138Growth hormone deficiency (HP:0000824)1.75963721
139Abnormal platelet volume (HP:0011876)1.75254606
140Obstructive sleep apnea (HP:0002870)1.75245890
141Hypoplastic female external genitalia (HP:0012815)1.74020942
142Labial hypoplasia (HP:0000066)1.73246800
143Hyperglycinuria (HP:0003108)1.72897987
144Abnormality of the diencephalon (HP:0010662)1.71021856
145Cystic liver disease (HP:0006706)1.70366927
146Abnormality of the heme biosynthetic pathway (HP:0010472)1.70176870
147Esophageal atresia (HP:0002032)1.70018614
148Pachygyria (HP:0001302)1.69964719
149Impaired social interactions (HP:0000735)1.69620980
150Abnormal social behavior (HP:0012433)1.69620980
151Sacral dimple (HP:0000960)1.69411166
152Meckel diverticulum (HP:0002245)1.67386409
153Lissencephaly (HP:0001339)1.66922153
154Partial duplication of the phalanx of hand (HP:0009999)1.66571380
155Cutaneous finger syndactyly (HP:0010554)1.65785466
156Thyroid-stimulating hormone excess (HP:0002925)1.65682472
157Hepatoblastoma (HP:0002884)1.65601753
158Abnormality of the ileum (HP:0001549)1.65539208
159Clonus (HP:0002169)1.65109721
160Abnormal hair whorl (HP:0010721)1.64962672
161Sporadic (HP:0003745)1.64762512
162Postaxial hand polydactyly (HP:0001162)1.64679951
163Coronal craniosynostosis (HP:0004440)1.64499890
164Conical tooth (HP:0000698)1.64211871
165Abnormality of the antihelix (HP:0009738)1.64154055
166Delusions (HP:0000746)1.63838819
167Recurrent corneal erosions (HP:0000495)1.63421431
168Menorrhagia (HP:0000132)1.62514164
169Preaxial hand polydactyly (HP:0001177)1.60930442
170Stenosis of the external auditory canal (HP:0000402)1.60616955
171Abnormality of glycine metabolism (HP:0010895)1.60381718
172Abnormality of serine family amino acid metabolism (HP:0010894)1.60381718

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.78010691
2MAP3K93.47564248
3NTRK32.99713101
4MINK12.53198878
5PAK62.41635752
6MAP3K42.38718324
7ZAK2.34148842
8UHMK12.28102326
9NTRK22.24180839
10MKNK22.22676835
11CASK2.17871384
12DYRK22.09902579
13TRIM282.09680839
14LATS22.04058328
15EPHA42.00486319
16MAP2K71.94458125
17MKNK11.94021873
18PNCK1.92076726
19MAPK131.83535746
20NUAK11.78812087
21PHKG21.74024337
22PHKG11.74024337
23TSSK61.68611007
24MST41.64412094
25KSR11.61321429
26CDK191.53767507
27PLK41.51392833
28BMPR1B1.51019108
29MAP4K21.50326065
30CDK51.48255388
31DAPK21.46578469
32PLK21.45987191
33STK38L1.45205018
34BUB11.42549892
35GRK51.37280230
36SRPK11.35755979
37NTRK11.33899545
38ADRBK21.22533861
39FRK1.20863551
40CDK181.20534800
41KSR21.19759724
42CDK141.17813340
43CDK151.17733302
44SGK4941.15064834
45SGK2231.15064834
46MAP2K41.14455046
47PAK31.09034069
48ICK1.08918452
49LIMK11.07186003
50VRK11.04449515
51CDK11A1.03524613
52TESK21.03281414
53FGFR21.03068021
54MARK21.02324971
55EIF2AK10.99545871
56CSNK1G20.99451235
57ACVR1B0.98153973
58DYRK1A0.97686619
59OXSR10.95640820
60INSRR0.95558361
61PRKD30.93883154
62DYRK30.90942130
63GRK10.89819707
64PLK10.87264296
65TAF10.85687944
66ALK0.85570858
67TYRO30.85553819
68PKN10.85119629
69ERBB30.82182929
70STK30.80522247
71CAMKK10.80510698
72PRKCG0.79815083
73BCR0.79607557
74TNIK0.78709510
75BMX0.77351240
76MAPK150.77312753
77STK240.76984659
78WEE10.76108932
79NME10.73617471
80MAPKAPK50.73570300
81WNK30.71293208
82NEK60.70737321
83CAMK2A0.70015371
84STK390.69454122
85SIK20.69258586
86SCYL20.68132023
87ROCK20.67586752
88CSNK1G30.67064326
89MAP3K120.66314354
90PRPF4B0.65587228
91STK110.65020091
92CAMK2B0.63819475
93WNK40.63564963
94BRSK20.61757507
95RET0.61221305
96MAP3K20.61114865
97DAPK10.60379818
98PRKCZ0.59920363
99VRK20.58718936
100* MAPK100.55834951
101TTK0.55314987
102ERBB20.54603184
103WNK10.52870976
104CSNK1A1L0.52636787
105AURKA0.52164466
106STK160.52090482
107TEC0.50843087
108ATR0.50130155
109FGFR10.48649067
110MAP2K60.46943964
111ATM0.46860943
112CSNK1E0.46409497
113PLK30.46214627
114CCNB10.46144620
115CHEK20.44859509
116DMPK0.44533036
117SGK20.43867631
118SGK10.43519304
119EPHB20.42606765
120LMTK20.42263898
121PINK10.42263542
122TIE10.42223960
123PBK0.41879215
124BRSK10.41810533
125CSNK1D0.41470029
126RPS6KA30.41266413
127TAOK10.40879182
128PRKG10.40692017
129CDC70.40155599
130STK380.39959895
131RPS6KA20.39945318
132* GSK3B0.39536521
133NLK0.39527868
134ARAF0.38706705
135CDK30.38566374
136LATS10.38546485
137PTK2B0.37353176
138TLK10.36905065
139CAMK1G0.36891002
140PRKCE0.35311261
141MAP3K60.34514949
142CSNK1G10.34183564
143* MAPK90.34120429

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.13198247
2Synaptic vesicle cycle_Homo sapiens_hsa047213.04066306
3Olfactory transduction_Homo sapiens_hsa047402.52825885
4Glutamatergic synapse_Homo sapiens_hsa047242.36559282
5GABAergic synapse_Homo sapiens_hsa047272.35321920
6Circadian entrainment_Homo sapiens_hsa047132.27366126
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.27180318
8Dopaminergic synapse_Homo sapiens_hsa047282.13296237
9Morphine addiction_Homo sapiens_hsa050322.11425337
10Long-term potentiation_Homo sapiens_hsa047202.11195496
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.00393579
12Axon guidance_Homo sapiens_hsa043601.98086115
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.95095322
14Amphetamine addiction_Homo sapiens_hsa050311.93553988
15Insulin secretion_Homo sapiens_hsa049111.76446948
16Taste transduction_Homo sapiens_hsa047421.75579243
17Cholinergic synapse_Homo sapiens_hsa047251.73994679
18Butanoate metabolism_Homo sapiens_hsa006501.72219832
19Mismatch repair_Homo sapiens_hsa034301.71469420
20Salivary secretion_Homo sapiens_hsa049701.69551497
21Long-term depression_Homo sapiens_hsa047301.67852605
22Gap junction_Homo sapiens_hsa045401.62840233
23Serotonergic synapse_Homo sapiens_hsa047261.62745531
24Nitrogen metabolism_Homo sapiens_hsa009101.58037399
25Cocaine addiction_Homo sapiens_hsa050301.57085765
26Oocyte meiosis_Homo sapiens_hsa041141.52395974
27Basal transcription factors_Homo sapiens_hsa030221.50736935
28Dorso-ventral axis formation_Homo sapiens_hsa043201.50519465
29Hedgehog signaling pathway_Homo sapiens_hsa043401.48982705
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47398931
31Gastric acid secretion_Homo sapiens_hsa049711.45681858
32Propanoate metabolism_Homo sapiens_hsa006401.43720494
33Fanconi anemia pathway_Homo sapiens_hsa034601.37746370
34Melanogenesis_Homo sapiens_hsa049161.36441912
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35777324
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.34529809
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.33681437
38Non-homologous end-joining_Homo sapiens_hsa034501.33099704
39Basal cell carcinoma_Homo sapiens_hsa052171.32460811
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29294370
41ErbB signaling pathway_Homo sapiens_hsa040121.29015689
42Homologous recombination_Homo sapiens_hsa034401.27931089
43Renin secretion_Homo sapiens_hsa049241.26886520
44Oxytocin signaling pathway_Homo sapiens_hsa049211.25144841
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22767936
46GnRH signaling pathway_Homo sapiens_hsa049121.21137513
47Colorectal cancer_Homo sapiens_hsa052101.18628197
48RNA polymerase_Homo sapiens_hsa030201.17104121
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16377456
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16072623
51beta-Alanine metabolism_Homo sapiens_hsa004101.15567524
52Phototransduction_Homo sapiens_hsa047441.14997451
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.14366293
54Estrogen signaling pathway_Homo sapiens_hsa049151.12964983
55Calcium signaling pathway_Homo sapiens_hsa040201.12602891
56Hippo signaling pathway_Homo sapiens_hsa043901.12050636
57Collecting duct acid secretion_Homo sapiens_hsa049661.11888974
58Wnt signaling pathway_Homo sapiens_hsa043101.11755981
59Parkinsons disease_Homo sapiens_hsa050121.08599763
60Linoleic acid metabolism_Homo sapiens_hsa005911.07045854
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03878488
62RNA degradation_Homo sapiens_hsa030181.03706798
63Type II diabetes mellitus_Homo sapiens_hsa049301.03196478
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02745953
65Selenocompound metabolism_Homo sapiens_hsa004501.02714545
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02239093
67cAMP signaling pathway_Homo sapiens_hsa040241.02049624
68Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01774677
69Glioma_Homo sapiens_hsa052141.01689269
70Alcoholism_Homo sapiens_hsa050341.00623108
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99969140
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96862654
73Endometrial cancer_Homo sapiens_hsa052130.95594462
74Renal cell carcinoma_Homo sapiens_hsa052110.94445530
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91424295
76Oxidative phosphorylation_Homo sapiens_hsa001900.91416260
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91226549
78Base excision repair_Homo sapiens_hsa034100.90609600
79Fatty acid elongation_Homo sapiens_hsa000620.90301038
80Huntingtons disease_Homo sapiens_hsa050160.89376734
81MAPK signaling pathway_Homo sapiens_hsa040100.89182430
82Ras signaling pathway_Homo sapiens_hsa040140.87159768
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85771499
84Protein export_Homo sapiens_hsa030600.85609523
85Purine metabolism_Homo sapiens_hsa002300.81966637
86Cardiac muscle contraction_Homo sapiens_hsa042600.81771643
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80001328
88DNA replication_Homo sapiens_hsa030300.78667257
89RNA transport_Homo sapiens_hsa030130.78435410
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.78118433
91Endocytosis_Homo sapiens_hsa041440.78098569
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77449399
93Cell cycle_Homo sapiens_hsa041100.77387604
94Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.77282936
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76244184
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75885074
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73644876
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73635590
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.73078052
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.72985315
101Vibrio cholerae infection_Homo sapiens_hsa051100.72764931
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.71747835
103* Choline metabolism in cancer_Homo sapiens_hsa052310.71522711
104Arginine and proline metabolism_Homo sapiens_hsa003300.71327876
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71234343
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70942353
107Rap1 signaling pathway_Homo sapiens_hsa040150.67586476
108Nucleotide excision repair_Homo sapiens_hsa034200.67207706
109Glycerolipid metabolism_Homo sapiens_hsa005610.66046491
110Platelet activation_Homo sapiens_hsa046110.65355181
111mRNA surveillance pathway_Homo sapiens_hsa030150.64489085
112Spliceosome_Homo sapiens_hsa030400.63674700
113Proteasome_Homo sapiens_hsa030500.63500267
114Vitamin B6 metabolism_Homo sapiens_hsa007500.63353109
115Ether lipid metabolism_Homo sapiens_hsa005650.61611022
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61029669
117mTOR signaling pathway_Homo sapiens_hsa041500.60541812
118Ovarian steroidogenesis_Homo sapiens_hsa049130.60235198
119Notch signaling pathway_Homo sapiens_hsa043300.60094627
120One carbon pool by folate_Homo sapiens_hsa006700.59568433
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57512003
122Arachidonic acid metabolism_Homo sapiens_hsa005900.56595716
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56422491
124Fatty acid metabolism_Homo sapiens_hsa012120.55020168
125Fat digestion and absorption_Homo sapiens_hsa049750.54169151
126Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53704776
127Prion diseases_Homo sapiens_hsa050200.53704055
128Tight junction_Homo sapiens_hsa045300.53309990
129Inositol phosphate metabolism_Homo sapiens_hsa005620.53255788
130Melanoma_Homo sapiens_hsa052180.52970623
131Tryptophan metabolism_Homo sapiens_hsa003800.52572282
132Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52350417
133VEGF signaling pathway_Homo sapiens_hsa043700.51628444
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49700929
135Pancreatic secretion_Homo sapiens_hsa049720.49272632
136Primary bile acid biosynthesis_Homo sapiens_hsa001200.49075066
137Non-small cell lung cancer_Homo sapiens_hsa052230.48622609
138Alzheimers disease_Homo sapiens_hsa050100.48237453
139Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47341136
140Peroxisome_Homo sapiens_hsa041460.47245743
141Steroid biosynthesis_Homo sapiens_hsa001000.47087338
142Thyroid hormone synthesis_Homo sapiens_hsa049180.46720749
143Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46097260
144Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45940458
145Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45659300
146SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42158433
147Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41237062
148Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41121791
149Prolactin signaling pathway_Homo sapiens_hsa049170.40531318
150Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39973529
151Insulin signaling pathway_Homo sapiens_hsa049100.38675121
152Pathways in cancer_Homo sapiens_hsa052000.37938083
153Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37753672

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